<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O69884</accession>
    <name>O69884_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5596</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34781">
        <property type="entry name" value="T34781"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629730.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030325.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5596"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="GeneID" id="1101037"/>
    <dbReference type="KEGG" id="sco:SCO5596"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5688"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_0_2_11"/>
    <dbReference type="InParanoid" id="O69884"/>
    <dbReference type="OMA" id="IEEAYLY"/>
    <dbReference type="PhylomeDB" id="O69884"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="49"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA19388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="27662" checksum="9D30961300A64A86" modified="1998-08-01" version="1">MDTETQHTERDRSSRPSDSEQPSEPEGPEERSRSAFTGRIGDWLPGGRITVTLLILLLFLLLVSTFVLQPFQIPSGSMERGLRIGDRVLVNKLAYRFDGRPRRGDIVVFDGTGSFGHGDYIKRVVGVGGDHVVCCDEEGRVRVNGQPVDESAFLYPGDRPSTVPFDVVVPDGTLFVLGDHRSDSSDSRDHLGSPGGGMVPLDDVIGRADWIVWPFGHATRLDRPDAYARVPDAEAGAGAASGAGAAPDPGAAPDGDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O86523</accession>
    <name>O86523_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5542</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29072">
        <property type="entry name" value="T29072"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973454.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5542"/>
    <dbReference type="GeneID" id="1100982"/>
    <dbReference type="KEGG" id="sco:SCO5542"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5630"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_1_1_11"/>
    <dbReference type="InParanoid" id="O86523"/>
    <dbReference type="OMA" id="AMCRQVR"/>
    <dbReference type="PhylomeDB" id="O86523"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="14089" checksum="35313BD3F3C9236B" modified="1998-11-01" version="1">MTPPTASHDPYAEPYEDEGDQPLVRPYAMTGGRTRPRYQLAIEALISTTADPAALMGLLPEHQRICHLCREVKSVAEVSALLAMPLGVARILVADLAEAGLVAIHQPGGDENNGGAPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O86694</accession>
    <name>O86694_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35057">
        <property type="entry name" value="T35057"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630724.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031074.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6648"/>
    <dbReference type="GeneID" id="1102087"/>
    <dbReference type="KEGG" id="sco:SCO6648"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6753"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2144342_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="112" mass="11864" checksum="A9C8A2B812DEEFB0" modified="1998-11-01" version="1">MARMARAFWLEAPGRGAIREVELPVPGADEVLVRALFSGVSRGTETLVFGGRVPENQYTAMRAPFQEGDFPGPVKYGYLGVGVGRRGRSGSSGAPCSVSTRTRPGTSSPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O86768</accession>
    <name>O86768_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP /GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5629</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35469">
        <property type="entry name" value="T35469"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629763.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030349.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5629"/>
    <dbReference type="DNASU" id="1101070"/>
    <dbReference type="GeneID" id="1101070"/>
    <dbReference type="KEGG" id="sco:SCO5629"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5718"/>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="InParanoid" id="O86768"/>
    <dbReference type="OMA" id="RAVAQTW"/>
    <dbReference type="PhylomeDB" id="O86768"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="886" mass="97715" checksum="605C15EAF8767212" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>O86808</accession>
    <name>O86808_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">SCO5748</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35681">
        <property type="entry name" value="T35681"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629873.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030433.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5748"/>
    <dbReference type="GeneID" id="1101190"/>
    <dbReference type="KEGG" id="sco:SCO5748"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5837"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_11"/>
    <dbReference type="InParanoid" id="O86808"/>
    <dbReference type="OMA" id="KNTINVM"/>
    <dbReference type="PhylomeDB" id="O86808"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
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        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="323"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="507"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="599"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="691"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="783"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="875"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="967"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1372"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1709"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1617"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1667"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1293"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1670"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAA19849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1829" mass="195752" checksum="C9C8699938C956A4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O87854</accession>
    <name>O87854_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2006-08" db="PDB data bank">
            <title>The crystal structure of a putative transcriptional regulator TetR from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Xu X."/>
                <person name="Zheng H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35787">
        <property type="entry name" value="T35787"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630678.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031034.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="PDB" id="2HXI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=1-217"/>
    </dbReference>
    <dbReference type="PDBsum" id="2HXI"/>
    <dbReference type="SMR" id="O87854"/>
    <dbReference type="STRING" id="100226.SCO6599"/>
    <dbReference type="GeneID" id="1102038"/>
    <dbReference type="KEGG" id="sco:SCO6599"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6706"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_5_1_11"/>
    <dbReference type="OMA" id="EGDWKQR"/>
    <dbReference type="PhylomeDB" id="O87854"/>
    <dbReference type="EvolutionaryTrace" id="O87854"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2HXI"/>
        </source>
    </evidence>
    <sequence length="217" mass="23650" checksum="ECB2134F06813502" modified="1998-11-01" version="1">MAGRRRWSTEQILDAAAELLLAGDAETFSVRKLAASLGTDSSSLYRHFRNKTELLRAVADRILLSAMDGYRPEGDWKQRLTAVALRLRESFGQQPQLAAVWGRHGSGGTGSRLMMEEVLQALRASGLPDDEIPARYHRLVILISSLITAEGGFGAVGAQEHEQGMEQFRVAVLGADPERFPALSHFAREIRPLGADRGAAFEEILAAHLAHLEAAAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>P16249</accession>
    <name>HIS5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber>4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>IGP synthase glutaminase subunit</fullName>
            <ecNumber>3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>ImGP synthase subunit HisH</fullName>
            <shortName>IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hisH</name>
        <name type="ordered locus">SCO2051</name>
        <name type="ORF">SC4G6.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Gene" volume="90" first="31" last="41">
            <title>Cloning and characterization of the histidine biosynthetic gene cluster of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Limauro D."/>
                <person name="Avitabile A."/>
                <person name="Cappellano M."/>
                <person name="Puglia A.M."/>
                <person name="Bruni C.B."/>
            </authorList>
            <dbReference type="PubMed" id="2199329"/>
            <dbReference type="DOI" id="10.1016/0378-1119(90)90436-U"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10"/>
    <dbReference type="EC" id="3.5.1.2"/>
    <dbReference type="EMBL" id="M31628">
        <property type="protein sequence ID" value="AAA26759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ0640">
        <property type="entry name" value="JQ0640"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626311.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976765.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P16249"/>
    <dbReference type="SMR" id="P16249"/>
    <dbReference type="STRING" id="100226.SCO2051"/>
    <dbReference type="GeneID" id="1097485"/>
    <dbReference type="KEGG" id="sco:SCO2051"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2082"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_1_0_11"/>
    <dbReference type="InParanoid" id="P16249"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="PhylomeDB" id="P16249"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152431" description="Imidazole glycerol phosphate synthase subunit HisH">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <sequence length="222" mass="23861" checksum="C075C84354744CB6" modified="1990-08-01" version="1">MTAAVPAGATGRAKKVVVFDYGFGNVRSAERALARAGADVEITRDYDKAMNADGLLVPGVGAFAACMEGLKAARGDWIVDRRLSGGRPVMGICVGMQILFSRGIEHDVEAEGLDEWPGTVGPLEADVVPHMGWNTVEAPADSQLFAGLDADARFYFVHSYAVHEWTQESHNPLIAEPRVTWSTHGKPFVAAVENGALWATQFHPEKSGDAGAQLLTNWIETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>P40175</accession>
    <accession>Q9K412</accession>
    <name>EFTU3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu-3</fullName>
            <shortName evidence="2">EF-Tu-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf3</name>
        <name type="ordered locus">SCO1321</name>
        <name type="ORF">2SCG61.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Biochim. Biophys. Acta" volume="1219" first="543" last="547">
            <title>Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="van Wezel G.P."/>
                <person name="Woudt L.P."/>
                <person name="Vervenne R."/>
                <person name="Verdurmen M.L."/>
                <person name="Vijgenboom E."/>
                <person name="Bosch L."/>
            </authorList>
            <dbReference type="PubMed" id="7918656"/>
            <dbReference type="DOI" id="10.1016/0167-4781(94)90085-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text>Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="X77040">
        <property type="protein sequence ID" value="CAA54330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S50139">
        <property type="entry name" value="S50139"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977508.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40175"/>
    <dbReference type="SMR" id="P40175"/>
    <dbReference type="STRING" id="100226.SCO1321"/>
    <dbReference type="GeneID" id="1096744"/>
    <dbReference type="KEGG" id="sco:SCO1321"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1324"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_11"/>
    <dbReference type="InParanoid" id="P40175"/>
    <dbReference type="OMA" id="TFGKPME"/>
    <dbReference type="PhylomeDB" id="P40175"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091402" description="Elongation factor Tu-3">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="84"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA54330." evidence="3" ref="1">
        <original>R</original>
        <variation>P</variation>
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="392" mass="41676" checksum="16E8CCC3A864B23A" modified="2001-10-18" version="2">MSKTAYVRTKPHLNIGTMGHVDHGKTTLTAAITKVLAERGAGSTTQYVSFDRIDRAPEEAARGITINIAHVEYETDTRHYAHVDMPGHADYVKNMVTGAAQLDGAILVVSALDGIMPQTAEHVLLARQVGVDHIVVALNKADAGDEELTDLVELEVRELLTAHGYGGDAVPVVRVSGLKALEGDPRWTASVEALLDAVDTYVPMPERYLDAPFLLPVENVLTITGRGTVVTGAVERGTVRVGDRVEVLGASVETVVTGLETFGKPMEEAQAGDNVALLLRGVARDTVRRGQVVAAPGSVVPARRFRARVYVLSAREGGRSTPLTTGYRPQFYIRTADVVGDVDLGEEAVARPGDTVTMTVELGRDVPLETGLGFAIREGGRTVGAGTVTAVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-05-25" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>P52230</accession>
    <name>THIO1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Thioredoxin 1</fullName>
            <shortName>Trx-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trxA</name>
        <name type="ordered locus">SCO3889</name>
        <name type="ORF">SCH24.11c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Gene" volume="217" first="83" last="90">
            <title>Gene organization in the trxA/B-oriC region of the Streptomyces coelicolor chromosome and comparison with other eubacteria.</title>
            <authorList>
                <person name="Gal-Mor O."/>
                <person name="Borovok I."/>
                <person name="Av-Gay Y."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
            </authorList>
            <dbReference type="PubMed" id="9795152"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(98)00357-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="1313" last="1320">
            <title>Partitioning of the linear chromosome during sporulation of Streptomyces coelicolor A3(2) involves an oriC-linked parAB locus.</title>
            <authorList>
                <person name="Kim H.-J."/>
                <person name="Calcutt M.J."/>
                <person name="Schmidt F.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="10671452"/>
            <dbReference type="DOI" id="10.1128/JB.182.5.1313-1320.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="EMBO J." volume="17" first="5776" last="5782">
            <title>sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Paget M.S."/>
                <person name="Kang J.G."/>
                <person name="Roe J.H."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="9755177"/>
            <dbReference type="DOI" id="10.1093/emboj/17.19.5776"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="EMBO J." volume="18" first="4292" last="4298">
            <title>RsrA, an anti-sigma factor regulated by redox change.</title>
            <authorList>
                <person name="Kang J.G."/>
                <person name="Paget M.S.B."/>
                <person name="Seok Y.J."/>
                <person name="Hahn M.Y."/>
                <person name="Bae J.B."/>
                <person name="Hahn J.S."/>
            </authorList>
            <dbReference type="PubMed" id="10428967"/>
            <dbReference type="DOI" id="10.1093/emboj/18.15.4292"/>
        </citation>
        <scope>FUNCTION WITH RSRA AS SUBSTRATE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="Acta Crystallogr. F Struct. Biol. Commun." volume="61" first="164" last="168">
            <title>Expression, purification and X-ray crystallographic analysis of thioredoxin from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Stefankova P."/>
                <person name="Maderova J."/>
                <person name="Barak I."/>
                <person name="Kollarova M."/>
                <person name="Otwinowski Z."/>
            </authorList>
            <dbReference type="PubMed" id="16510983"/>
            <dbReference type="DOI" id="10.1107/S1744309104032993"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Stimulates complex formation between sigma factor SigR and its cognate anti-sigma factor RsrA probably by reducing RsrA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expressed from 2 promoters, 1 of which (trxBp1) is under control of SigR, and further transiently induced (about 50-fold) by the thiol-oxidizing agent diamide. Part of the trxB-trxA operon.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAA63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CAA63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CAA07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AAC03481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AAF16002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CAB42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T36576"/>
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        <property type="entry name" value="T42061"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975042.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDB" id="1T00">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.51 A"/>
        <property type="chains" value="A=1-110"/>
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    <dbReference type="PDBsum" id="1T00"/>
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    <dbReference type="KEGG" id="sco:SCO3889"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3962"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="EvolutionaryTrace" id="P52230"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000120136" description="Thioredoxin 1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA63074/CAA07452." evidence="5" ref="1">
        <original>KP</original>
        <variation>NA</variation>
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="6"/>
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        </location>
    </feature>
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            <begin position="10"/>
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        </location>
    </feature>
    <feature type="helix" evidence="6">
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            <begin position="13"/>
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        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="50"/>
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        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="75"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="strand" evidence="6">
        <location>
            <begin position="86"/>
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        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="97"/>
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        </location>
    </feature>
    <feature type="helix" evidence="6">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10428967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9755177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="1T00"/>
        </source>
    </evidence>
    <sequence length="110" mass="11892" checksum="18AA0F89F7E513A8" modified="2001-06-01" version="4">MAGTLKHVTDDSFEQDVLKNDKPVLVDFWAAWCGPCRQIAPSLEAIAAEYGDKIEIVKLNIDENPGTAAKYGVMSIPTLNVYQGGEVAKTIVGAKPKAAIVRDLEDFIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKD2</accession>
    <name>Q7AKD2_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7337</name>
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    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631391.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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    <dbReference type="RefSeq" id="WP_003971804.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7337"/>
    <dbReference type="GeneID" id="1102775"/>
    <dbReference type="KEGG" id="sco:SCO7337"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7441"/>
    <dbReference type="eggNOG" id="COG2172">
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    <dbReference type="HOGENOM" id="CLU_090336_1_0_11"/>
    <dbReference type="OMA" id="SDGWGCC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="19043" checksum="C5147C760DDDBD8A" modified="2012-05-16" version="1">MKTAVPCYYHLDVEVSPERVGQVRRILAAHLRFWNLENLVEPVCSGAEMLLLAIDEHASDKNTSIEMWWNHQHLITAVGGNDHALRPDQDLRTCLQHLAANSDGWGCCATDTGAKVIWFSRRARAGERVPLVATDPEPITQEGLEVPREIMPVARVAGRARTSDGVLEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q7APM9</accession>
    <accession>Q9L8G9</accession>
    <name>Q7APM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCP1.318</name>
        <name evidence="6" type="ordered locus">SCP1.36c</name>
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    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5 8">
        <name>SCP1</name>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="8">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="1999-11" db="EMBL/GenBank/DDBJ databases">
            <title>Transcriptional Analysis of the Genome of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Gust B."/>
                <person name="Spychaj A."/>
                <person name="Spatz K."/>
                <person name="Redenbach M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="8">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="8">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="8">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="8">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF204735">
        <property type="protein sequence ID" value="AAF26373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639612.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639926.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039338.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095115"/>
    <dbReference type="GeneID" id="1095400"/>
    <dbReference type="KEGG" id="sco:SCP1.318"/>
    <dbReference type="KEGG" id="sco:SCP1.36c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7982"/>
    <dbReference type="HOGENOM" id="CLU_000445_81_0_11"/>
    <dbReference type="OMA" id="TRWRIEL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
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    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF26373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC36558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC36843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="304" mass="32851" checksum="303BD5A04C62922F" modified="2004-07-05" version="1">MDPLEDVLTLLKTRSHLSASLVAGGRWAVRFDAPRVVKFNAVRRGTCQLEVDGIDEPIDLAEGDCYLLTRPRSFTLRSDPETAPVDGGAVFARAEDGIARAGQGDDVFLIGGGFSFGTRAQELLLDRLPPIVHVPADTPHAETVQWALTAIDQELTHRPMASTLIAEHLAVIMLVHVLRLHLERAPHAVSGWLAGLADPVVATALTCLHRDPARSWTVADLADTAAVSRSTLAARFKATVGQGPLEYLTRWRIELAARQLREGNATLASIAHSVGYGSESALSVAFKRVLGMPPGDYRKHPTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q7ZAI8</accession>
    <name>Q7ZAI8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4937</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_629090.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029961.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4937"/>
    <dbReference type="GeneID" id="1100378"/>
    <dbReference type="KEGG" id="sco:SCO4937"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5017"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_1_11"/>
    <dbReference type="InParanoid" id="Q7ZAI8"/>
    <dbReference type="OMA" id="QIVGSTY"/>
    <dbReference type="PhylomeDB" id="Q7ZAI8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="18486" checksum="3A0213DE136DA116" modified="2003-10-01" version="1">MTTTTDTTTTAEQDGTRSRLPDPTGLYPELTALSAAVQKALRNGPVPQATLALTRLRTAQVIGSTYHGVAATDALRKAGEEERRITAVATWQSAPCFTAPERAALELAEAVLTPNPFGDRVSDDLFARLSRHYDTDGIWHLTMALGHFSLFTPVALVGKPVPGRPPGKNYTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJM2</accession>
    <name>PGLX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenine-specific methyltransferase PglX</fullName>
            <ecNumber evidence="4">2.1.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Bacteriophage (PhiC31) resistance gene PglX</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Putative type II restriction enzyme and methyltransferase RM.ScoA3ORF6627P</fullName>
            <shortName evidence="7">RM.ScoA3ORF6627P</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pglX</name>
        <name type="synonym">SC1F2.24</name>
        <name type="ordered locus">SCO6627</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Mol. Microbiol." volume="7" first="329" last="336">
            <title>Genetic analysis of the phi C31-specific phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Laity C."/>
                <person name="Chater K.F."/>
                <person name="Lewis C.G."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="8446035"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1993.tb01124.x"/>
        </citation>
        <scope>GENETIC ANALYSIS</scope>
        <scope>PHASE REVERSION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="44" first="489" last="500">
            <title>Genetics of the phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Sumby P."/>
                <person name="Smith M.C."/>
            </authorList>
            <dbReference type="PubMed" id="11972785"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2002.02896.x"/>
        </citation>
        <scope>FUNCTION IN ANTIVIRAL DEFENSE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Bacteriol." volume="185" first="4558" last="4563">
            <title>Phase variation in the phage growth limitation system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Sumby P."/>
                <person name="Smith M.C."/>
            </authorList>
            <dbReference type="PubMed" id="12867465"/>
            <dbReference type="DOI" id="10.1128/jb.185.15.4558-4563.2003"/>
        </citation>
        <scope>INVOLVED IN PHASE VARIATION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="Nucleic Acids Res." volume="31" first="1805" last="1812">
            <title>A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.</title>
            <authorList>
                <person name="Roberts R.J."/>
                <person name="Belfort M."/>
                <person name="Bestor T."/>
                <person name="Bhagwat A.S."/>
                <person name="Bickle T.A."/>
                <person name="Bitinaite J."/>
                <person name="Blumenthal R.M."/>
                <person name="Degtyarev S.K."/>
                <person name="Dryden D.T."/>
                <person name="Dybvig K."/>
                <person name="Firman K."/>
                <person name="Gromova E.S."/>
                <person name="Gumport R.I."/>
                <person name="Halford S.E."/>
                <person name="Hattman S."/>
                <person name="Heitman J."/>
                <person name="Hornby D.P."/>
                <person name="Janulaitis A."/>
                <person name="Jeltsch A."/>
                <person name="Josephsen J."/>
                <person name="Kiss A."/>
                <person name="Klaenhammer T.R."/>
                <person name="Kobayashi I."/>
                <person name="Kong H."/>
                <person name="Krueger D.H."/>
                <person name="Lacks S."/>
                <person name="Marinus M.G."/>
                <person name="Miyahara M."/>
                <person name="Morgan R.D."/>
                <person name="Murray N.E."/>
                <person name="Nagaraja V."/>
                <person name="Piekarowicz A."/>
                <person name="Pingoud A."/>
                <person name="Raleigh E."/>
                <person name="Rao D.N."/>
                <person name="Reich N."/>
                <person name="Repin V.E."/>
                <person name="Selker E.U."/>
                <person name="Shaw P.C."/>
                <person name="Stein D.C."/>
                <person name="Stoddard B.L."/>
                <person name="Szybalski W."/>
                <person name="Trautner T.A."/>
                <person name="Van Etten J.L."/>
                <person name="Vitor J.M."/>
                <person name="Wilson G.G."/>
                <person name="Xu S.Y."/>
            </authorList>
            <dbReference type="PubMed" id="12654995"/>
            <dbReference type="DOI" id="10.1093/nar/gkg274"/>
        </citation>
        <scope>NOMENCLATURE</scope>
        <scope>SUBTYPE</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="EMBO J." volume="34" first="169" last="183">
            <title>BREX is a novel phage resistance system widespread in microbial genomes.</title>
            <authorList>
                <person name="Goldfarb T."/>
                <person name="Sberro H."/>
                <person name="Weinstock E."/>
                <person name="Cohen O."/>
                <person name="Doron S."/>
                <person name="Charpak-Amikam Y."/>
                <person name="Afik S."/>
                <person name="Ofir G."/>
                <person name="Sorek R."/>
            </authorList>
            <dbReference type="PubMed" id="25452498"/>
            <dbReference type="DOI" id="10.15252/embj.201489455"/>
        </citation>
        <scope>CLASSIFICATION AND NOMENCLATURE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2015" name="Virology" volume="477" first="100" last="109">
            <title>The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.</title>
            <authorList>
                <person name="Hoskisson P.A."/>
                <person name="Sumby P."/>
                <person name="Smith M.C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25592393"/>
            <dbReference type="DOI" id="10.1016/j.virol.2014.12.036"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF TYR-381</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 10 11">BREX systems (bacteriophage exclusion) provide immunity against bacteriophage. Part of a type 2 BREX system (Probable). Probably a DNA methyltransferase, it methylates phage DNA in vitro in an S-adenosyl-L-methionine-dependent manner (PubMed:25592393). Previously called the phage growth limitation (Pgl) system, it confers protection against bacteriophage phiC31. The bacteria allows one cycle of phage infection, but subsequent cycles are impaired, protecting the original bacterial colony (Probable). The system undergoes high rates (10(-3) to 10(-4)) of phase reversion, i.e. loss and regain of phiC31 resistance (PubMed:8446035, PubMed:12867465). When the pglW-pglX-pglY-pglZ genes are transformed into a susceptible S.lividans (strain 1326) they confer resistance to infection by phage phiC31 and phiBT1; all 4 genes are necessary (PubMed:11972785).</text>
    </comment>
    <comment type="function">
        <text evidence="4">Probably a toxic component of a type II toxin-antitoxin (TA) system. The toxic activity is inhibited by its cognate antitoxin PglZ.</text>
    </comment>
    <comment type="function">
        <text evidence="7">May be a subtypes G and alpha restriction enzyme that recognizes and cleaves an unknown sequence. Methylates an adenine residue in the same sequence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="induction">
        <text evidence="2">Constitutively expressed, probably part of a pglW-pglX operon.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2 4">Strain is no longer resistant to plaque formation by bacteriophage phiC31 (a Pgl- phenotype).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">Phase reversion of this Pgl system is due in part to the expansion and contraction of an 8-base long guanine tract in this protein (corresponding to residues 259-263). The tract has been observed to be 7, 8 and 9 nucleotides long in different derivatives; a 7-G tract yields a 282 residue and the 9-G tract a 336 residue missense protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. PglX adenine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="4"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAD55384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29133">
        <property type="entry name" value="T29133"/>
    </dbReference>
    <dbReference type="PIR" id="T35036">
        <property type="entry name" value="T35036"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031053.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8CJM2"/>
    <dbReference type="STRING" id="100226.SCO6627"/>
    <dbReference type="REBASE" id="17310">
        <property type="entry name" value="ScoA3ORF6627P"/>
    </dbReference>
    <dbReference type="GeneID" id="1102066"/>
    <dbReference type="KEGG" id="sco:SCO6627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6735"/>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269467_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJM2"/>
    <dbReference type="PhylomeDB" id="Q8CJM2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-1277">Toxin-antitoxin system</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000452165" description="Adenine-specific methyltransferase PglX">
        <location>
            <begin position="1"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Does not restore phage resistance to a deletion mutant, very little DNA methylation occurs in vitro." evidence="4">
        <original>Y</original>
        <variation>A</variation>
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12867465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25592393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="8446035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="12654995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="25592393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="25452498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="25592393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1210" mass="136254" checksum="9CBEEE2FFD5F6F90" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJP5</accession>
    <name>Q8CJP5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6054</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAD55368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34692">
        <property type="entry name" value="T34692"/>
    </dbReference>
    <dbReference type="PIR" id="T35846">
        <property type="entry name" value="T35846"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733685.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972867.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6054"/>
    <dbReference type="GeneID" id="1101495"/>
    <dbReference type="KEGG" id="sco:SCO6054"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6155"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_11_2_11"/>
    <dbReference type="InParanoid" id="Q8CJP5"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="PhylomeDB" id="Q8CJP5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015138">
        <property type="term" value="F:fumarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015741">
        <property type="term" value="P:fumarate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="15"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="496" mass="50767" checksum="CB35D319B876B1AC" modified="2003-03-01" version="1">MSPIADRNRRFPHWRQDLTASLVVFLVALPLCVGVAVASGVPAELGLVTGIVGGLVTGFLPGSSLQVSGPAAGLTVLVFGAVDQYGLPALGVIVLATGIVQLAMGALKLGRWFRAISLSVVEGMLAGIGLVLIAGQLYSAAGLQAPASGIDKLTGLPGAAADALGSTGALTSLALGAGTVAVMVLWKRLPKRARTVPGALAAVGLATAVTATFGLSVATVEVSGLLDVIQPPGADAFGELANVGLLGTIVAFTLIASAESLFSAAAVDRLHDGPRTEYDKELMAQGAGNTVCGILGALPMTAVIVRSSANVAAGARTKASRVLHGVWLLLFAALLPSVLGLIPLPALAGILVHAGWKLIPFRSILPLWRDHRGEALILVVTAVSIVAVNMFEGVLIGLALSVVKTAWEASHLKLEIVDKGAGPVQAHLTGNATFLRLPKILEGLEALPQDRPVELDLSGLHHLDHACRTALENWAERHSAAGTDPVKVTEPERAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJU7</accession>
    <name>Q8CJU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAD55472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029443.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4115"/>
    <dbReference type="GeneID" id="1099552"/>
    <dbReference type="KEGG" id="sco:SCO4115"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4176"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020311_0_0_11"/>
    <dbReference type="OMA" id="MVPARVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="273"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="707" mass="72609" checksum="169222E535BC2A4F" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J51</accession>
    <name>Q93J51_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO3052</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627273.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975759.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3052"/>
    <dbReference type="GeneID" id="1098485"/>
    <dbReference type="KEGG" id="sco:SCO3052"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3112"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_11"/>
    <dbReference type="InParanoid" id="Q93J51"/>
    <dbReference type="OMA" id="IELANTH"/>
    <dbReference type="PhylomeDB" id="Q93J51"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="328"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="447" mass="47875" checksum="A8B6000F9F1574E7" modified="2001-12-01" version="1">MALKITVIGTGYLGATHAAAMAELGFEVLGLDVVPEKIETLQRGEVPMYEPGLRELLGKHVAGIEGSSGRLRFTTDFAEVAAFGDVHFLCVNTPQKHGEYACDMSYVDSALASLAPHLTGPALVVGKSTVPVGSADRLAAYLAEHAPAGDGAELAWNPEFLREGFAVEDTLHPDRLVVGVRSERAERLLREVYATPIEEGSPFVVTDFPTAELVKTAANSFLATKISFINAMAEVCEAAGGDVAKLAEAIGYDDRIGKKFLRAGIGFGGGCLPKDIRAFMARAGELGADQALTFLREIDSVNMRQRGRMVELTRQALGGGPFLGKRVAVLGATFKPDSDDVRDSPALNVAGQVHLQGAQVTVYDPKGMENARRLFPTLGYADSALEAVRGADVVLHLTEWREFRELDPEVLGEAAAARVILDGRNALDPALWRKAGWTYRAMGRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J63</accession>
    <name>Q93J63_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0981</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625277.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027490.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0981"/>
    <dbReference type="GeneID" id="1096404"/>
    <dbReference type="KEGG" id="sco:SCO0981"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.978"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046383_0_0_11"/>
    <dbReference type="InParanoid" id="Q93J63"/>
    <dbReference type="OMA" id="QRAFPPI"/>
    <dbReference type="PhylomeDB" id="Q93J63"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC44331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="489" mass="53978" checksum="9A35F5C5E2F19942" modified="2001-12-01" version="1">MSKTYAGARLRRLREERRLSQAALARVLGISPSYLNQMEHDSRPLTVPVLLRLTETLGVDAAFFSERDTARLLADLREALTGELAVARVSASDLAELASRMPAVAQVLIDLGRRNQLLSERLAGATDGRDGDRSTAPSPHEEIRDFFYRRQNYLHDTDLAAEHLAREIGIRPGEVIGALTGRLADAHGVRLGAEPGERLHRYDRRGRTLHLSPRLRPGQRAFRMATQIALLEHDEALGRLAAQDFEPGSPAHALARIGIANYFAAALILPYTAFHAAAEEFRYDIERLTDHYGLGYETVGHRLSTLQRPRLRGVPFSFVRVDRAGNMSKRQSATGFHFSRAGGTCPLWNVYESFATPGRIHVQLSEMPDGQRYLWTARAVTRHRGGWGEPGKTYAIGLGCEIRHAHRLVYSDGLDLDNASAATPIGMGCRVCERLDCPQRAAPPLGRALRIDPDSSTFVPYPVADPDSRPDRGAVRASADASKDRPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA6</accession>
    <name>Q93JA6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7490</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631537.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7490"/>
    <dbReference type="GeneID" id="1102928"/>
    <dbReference type="KEGG" id="sco:SCO7490"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7602"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_9_0_11"/>
    <dbReference type="InParanoid" id="Q93JA6"/>
    <dbReference type="OMA" id="WGIWGHR"/>
    <dbReference type="PhylomeDB" id="Q93JA6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046187">
        <property type="term" value="P:acetaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="42"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="381" mass="40071" checksum="DB6F2594EC0A81F9" modified="2001-12-01" version="1">MSSVPSVPSVPPVPPVPPVPSVPSVSSVPPASSVERVVQFTGPRQVEVAEHTRAALPPGHLRVRTRYSGISAGTELTAYRGTNPYLTRTWDPGARLFRDGAPGIEYPVAGWGYSEVGEVVEVSPELAGTPGLPVPGDLVWGIWGHRSEGIVPAERMVGHTLPAGLEPLAGAFARVGAIAYNAVLAGDIHLGEDVAVFGQGVIGLLTTRLARLSGARVTAVDALDGRLETAKHYGARHTLNARTDAVAERVREATGGLGADLAIEISGAYPALHEALRSVAAGGRVVASGFYQGDGIGLRLGDEFHHNRVQLICSQIGGVPPQLSNRWSVERLQQTFLRLVAEGQVDVDSLVSHVVPVADAADAYVLLDERPAEALQVVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RZ9</accession>
    <name>Q93RZ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624884.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027210.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0571"/>
    <dbReference type="GeneID" id="1095994"/>
    <dbReference type="KEGG" id="sco:SCO0571"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.552"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_2_11"/>
    <dbReference type="InParanoid" id="Q93RZ9"/>
    <dbReference type="OMA" id="YAERAVW"/>
    <dbReference type="PhylomeDB" id="Q93RZ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="200"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="442" mass="47919" checksum="36762DD638C2CA28" modified="2001-12-01" version="1">MSTTAPAVVPASEEAQREVVDLCAELIRFDTSNPTSDERACADWVVARLAEAGIASELVESAPGRANVVARIPGADTSRGALLVHGHLDVVPADAAEWRVPPFSGEIQDGYLWGRGAIDMKDTVAVMLATARHFARTGTRPAREIVLAFLADEEAGGKFGAHWLVEHRPELFAGVTEAIGEGGGFSYALDDTRRLYPIENAQRGMAWMELTAAGRAGHGSSPNDENAVTDLAESLTRIGRHTFPVRLIEPVRALLAEAARLQAVDLDLDAEDLEAELAKLGHVADFMQVVLRNSANPTMFTAGYQTNVIPGRATARVDGRFLPGHEQELIDTIDALLLPSVSREWVNHDIAMETSFDGPLVDAMCAAVRAEDPDGHPVPYCNPGGTDAKAFTKLDIRCFGFKGLKLPHDLDYGRLFHGVDERVPLEGLRFGVRVMTRLWQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q93S11</accession>
    <name>Q93S11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6278</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630376.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030790.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
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    <sequence length="543" mass="55659" checksum="20E47AD684974CFA" modified="2001-12-01" version="1"> </sequence>
</entry>
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    <accession>Q9ACY9</accession>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
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                <person name="James K.D."/>
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                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
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                <person name="O'Neil S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GeneID" id="1095237"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="7240" checksum="8D1F83211624B5A6" modified="2001-06-01" version="1">MTVEEATTATSQTAEGVKSSASILALAQYHGVEMPLTEVVVAVINGTLTVEDAASLLMSRTPKTERYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD13</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">SCP1.137c</name>
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        </lineage>
    </organism>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639710.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039436.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095215"/>
    <dbReference type="KEGG" id="sco:SCP1.137c"/>
    <dbReference type="HOGENOM" id="CLU_2332328_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="10832" checksum="E71D56B3F1F82265" modified="2001-06-01" version="1">MWCVLLTAAQSRSTRNHRCFRLPSVAQLGQHRTWMAIKQWVAFGEGLSFDADSVPYAVEVRTRSGSACSNDALTETLTTRERGPGRGEWAGVHQLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADF8</accession>
    <name>Q9ADF8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630213.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972815.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6105"/>
    <dbReference type="GeneID" id="1101546"/>
    <dbReference type="KEGG" id="sco:SCO6105"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6208"/>
    <dbReference type="eggNOG" id="COG3284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037518_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADF8"/>
    <dbReference type="OMA" id="VLWREGS"/>
    <dbReference type="PhylomeDB" id="Q9ADF8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="107"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="46941" checksum="BD64C7D4ADC6D6D5" modified="2001-06-01" version="1">MALSPMDVTRFAAADTARAARMLNEVRTARLSGGRAPVAPRPVIEQSWDRMLRSGVDPEHDFRSGLLTPEEVLRRRECSELRHVLPVLREALLSVADVAHHIMVVADEDGRVLWREGSARVLRRADGLGFELGADWREEVVGTNGVGTPAVTRRPVQVFASEHFVRSQATWTCAGAPITDPRSGRLLGVVDVSGPLETMHPATLAWVDSVAKLAEARLRELHTRSLDRLRAVAAPALARLEGRALVTDRDGWTAAVTGMPYLDRVVLPKSPVAGIRWLPAFGACTVEPLAGGWLVRAAAGPAGPDATRIVLDLAQPRRWSVRVLGGAEDWARELSPRHAELLYLLAVHRSGRSAAGLAEDMFGDPARTVTVRAEMSRVRRYLGTYLEHRPYRFCEDAEVEILLPADLQDLLPHSTAPAVARRRVSPGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK50</accession>
    <name>Q9AK50_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sugar translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4876</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629029.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974096.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4876"/>
    <dbReference type="GeneID" id="1100317"/>
    <dbReference type="KEGG" id="sco:SCO4876"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4956"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_5_0_11"/>
    <dbReference type="InParanoid" id="Q9AK50"/>
    <dbReference type="OMA" id="NCYFVYK"/>
    <dbReference type="PhylomeDB" id="Q9AK50"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="16201" checksum="BA0A47F9D73DB668" modified="2001-06-01" version="1">MPTAQTRPMARQIATFAVVGVVNTGLYYGLYLLLLTRLPYLLAHVLAFLLSMVGSFFLNARFTYRTRPTWRKFLLFPLTNAANFAITTAGVYVIVDVLRAGSRFAPLLASAAAIPVTFVVSRWIMLPHAGRAPGPETARASAEADALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK77</accession>
    <name>Q9AK77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4040</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029399.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4040"/>
    <dbReference type="GeneID" id="1099476"/>
    <dbReference type="KEGG" id="sco:SCO4040"/>
    <dbReference type="HOGENOM" id="CLU_1703191_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="154" mass="16309" checksum="2926C3EBED895B78" modified="2001-06-01" version="1">MRTRAAAQQRPCRRHVRIVRGFSRSPRTSVTTNVGAARDLPRPGQEVLPGGGTTEELPAEGAHAHRVPQPGGLGAARLHAVPQLPGLRQVAQELGPAPTPFGLTLPLPLRHRTRLGPALGTPLGAGGRHVVEVPVRHSLTTQRLSLPPSPDRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="146" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EVK2</accession>
    <name>Q9EVK2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ordered locus">SCO5285</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC04500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629430.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030152.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5285"/>
    <dbReference type="GeneID" id="1100726"/>
    <dbReference type="KEGG" id="sco:SCO5285"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5370"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_11"/>
    <dbReference type="InParanoid" id="Q9EVK2"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="PhylomeDB" id="Q9EVK2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="610"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="743"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC04500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="807" mass="86646" checksum="496CC83CDAD01932" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWE1</accession>
    <name>Q9EWE1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ECF sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4866</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629020.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974105.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4866"/>
    <dbReference type="GeneID" id="1100307"/>
    <dbReference type="KEGG" id="sco:SCO4866"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4944"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_10_0_11"/>
    <dbReference type="OMA" id="RMAAHRG"/>
    <dbReference type="PhylomeDB" id="Q9EWE1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="23597" checksum="AE24FECAE9129162" modified="2001-03-01" version="1">MLGDDAELTAAVRAAQDGDETAFRTVYRAVQPRLLGYVRTLVGDPDAEDVASEAWLQIARDLERFDGDADRFRGWAARIARNRALDHIRMRGRRPVIGGDETELTGRPAESDTAGEAMEALATGSTLSLIARLPQDQAEAVVLRVVMGLDAKSAAETLGKRPGAVRTAAHRGLKRLAELLGGDPESGGGLDALPPQREPHGRAVTSASVTHTRARTQKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWG3</accession>
    <name>Q9EWG3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4962</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029975.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4962"/>
    <dbReference type="GeneID" id="1100403"/>
    <dbReference type="KEGG" id="sco:SCO4962"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5042"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_11"/>
    <dbReference type="InParanoid" id="Q9EWG3"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="PhylomeDB" id="Q9EWG3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD30948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="409" mass="42280" checksum="9F21A40D3ECEA9B9" modified="2001-03-01" version="1">MSYSTASCVAPVTLDDVRGAQKMLSGVARVTAMEGSRHLSQLVGSPVHLKCENLQRTGSFKLRGAYVRIAGLLPEQRAAGVVAASAGNHAQGVALASSLLGVRSTVFMPQGAPLPKISATRDYGAEVRLHGQVVDETLAAAQEYAERTGAVFIHPFDHPDVIAGQGTVGLEILEQCPEVRTVVVGIGGGGLAAGIAVAVKALRPDVRIVGVQAEGAAAYPPSLAAGRPVAVQNPATMADGIKVGRPGDVPFGIVGELVDEVRTVSEDALSTALLLCLERAKLVVEPAGASPVAALLSEPDAFEGPVVAVLSGGNVDPVLMQGVLRHGMAAQGRYLAVRLRLTDRPGALATLLGVLSVVDANVLDVSHVRTHPRLGLTEAEVELHLETKGPEHCTEVGRVLREAGYTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWW7</accession>
    <name>Q9EWW7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC12932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626031.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977065.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1759"/>
    <dbReference type="GeneID" id="1097190"/>
    <dbReference type="KEGG" id="sco:SCO1759"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1777"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_2_11"/>
    <dbReference type="InParanoid" id="Q9EWW7"/>
    <dbReference type="OMA" id="GLWKPRV"/>
    <dbReference type="PhylomeDB" id="Q9EWW7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC12932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="23212" checksum="25D60FD91C09B24E" modified="2001-03-01" version="1">MTASSAAPAPSEKGAEVGRRIGVGLMYGLWKPRVLGAWRVPATGPVIYAVNHAHNIDGPMVMGVAPRPTHFLIKKEAFVGPLGRFLTGIGQLKVDRHSADRAAIGQALGVLADGGVLGIFPEGTRGEGDFASLRAGLAYFAVRSGAPIVPVAVLGSTDRPGRLIKALPPLRSRVDVVFGDPFDAGDGSGRRTRKALDEATERIQKQLTAHLENARRLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWZ0</accession>
    <name>Q9EWZ0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1136</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625429.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977695.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1136"/>
    <dbReference type="GeneID" id="1096559"/>
    <dbReference type="KEGG" id="sco:SCO1136"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1133"/>
    <dbReference type="eggNOG" id="COG4565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_39_1_11"/>
    <dbReference type="InParanoid" id="Q9EWZ0"/>
    <dbReference type="OMA" id="VGRPERC"/>
    <dbReference type="PhylomeDB" id="Q9EWZ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="28117" checksum="AF98EB1231899675" modified="2001-03-01" version="1">MTATSGTPDATAPTAAPLKTPPVAAPIGVLVVDDDFMVARVHRAFVERVEPFRVLGVAGTGEQALAAVGELRPDLVLLDLYLPDVFGLDVIPRLRAAGHDCDVMVISAAREADAVRGAVRHGVVDYLLKPFEFEDLRVRLQRYAVQRGRLLGTVVRSQADVDRVLAGAAAPAGPAPGLPKGMSVETAELVERALREADGTLSASECAALTGISRVSARRYLEYFHTVGSAEVSLRYGVAGRPERRYRFRGAVTGPELRRAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2L1</accession>
    <name>Q9F2L1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P450 oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627960.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029223.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3770"/>
    <dbReference type="GeneID" id="1099206"/>
    <dbReference type="KEGG" id="sco:SCO3770"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3829"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2L1"/>
    <dbReference type="OMA" id="QLKIIWE"/>
    <dbReference type="PhylomeDB" id="Q9F2L1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC10308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="394" mass="41575" checksum="22284EA3761B70E7" modified="2001-03-01" version="1">MGSAPRLIVSLTGGPMTAPTYEELAALRAVGAVHRVFVPGSGESRLVVTRDAARAALTDPRLRNDIRHSASWDSDGGHAIGHNMLQSDPPQHTRLRRLVAGHFTPGRTAALRPRVERIAHDLLDALPPAGTADLVARYALPLPVTVICELLGVPESDRGTFHTWSNELVMPTSPEAAGSAATALTGYLTELTDAKRRTPDGTLLGDLVAAADSGELTPGELLGMAFLILVAGHETTVNLISATVHGLLTHPGQLARLRAEPELTEAAVEESLRYHSPVHASAFRFAAEPLELAGTAIAAGDPVLVSLAAASRDPAHFPDPDRFDIGRRPRGHLGFGHGPHHCLGAPLARVEAAVAVRLLLDRHPALALAAGPATLTWRTSTLLRGLVELPVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2M0</accession>
    <name>Q9F2M0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3761</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627951.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975181.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3761"/>
    <dbReference type="GeneID" id="1099197"/>
    <dbReference type="KEGG" id="sco:SCO3761"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3821"/>
    <dbReference type="eggNOG" id="ENOG5031N3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1569769_0_0_11"/>
    <dbReference type="OMA" id="FWITEDS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC10299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="18004" checksum="E2FF0EB038732EC0" modified="2001-03-01" version="1">MAMVGLFWITEGCVYLGAKPAGAGPGVRLTEGGVEILGTGQGGRSWGWDEVRGLDVRDVAVRSAGRRLASMAFDSVVVLITGDGEQPPLFTVLVETEGDGTVEASVLAAVTGGIHTPDEYDLSRALLARLADGTTTVGELLRWRRDEPEDVAPAKDQRLALLREWTAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2N4</accession>
    <name>Q9F2N4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3116</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627334.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028779.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3116"/>
    <dbReference type="GeneID" id="1098550"/>
    <dbReference type="KEGG" id="sco:SCO3116"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3182"/>
    <dbReference type="eggNOG" id="COG1372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_839158_0_0_11"/>
    <dbReference type="OMA" id="NKCLRDH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032869">
        <property type="entry name" value="WHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14414">
        <property type="entry name" value="WHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="160"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC09557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="35705" checksum="96F92F8266B9C30F" modified="2001-03-01" version="1">MTTGRLGQAAAPPNAAYAGQVVHFPDPVRAARHPRGVRVDAGGYPEFSPYARAVAEIADPPEGFGVDELRLTDYVSANAVLSASGHELWDTVPAVATPHGWTWHHVAGSRRMELVPVEVKALLRHHGGISTAVVDQGKRGTRPLQETRPVHFGLPKSGVAVTEQQVQGVEEDLGYRLPGAYRSFLKAAGGCAPVGTALDAELGLLVDQPFFTVREEAAVNDLVYVNKCLRDHLTKDYLGVAFVQGGLLAVKVKGERIGSVWFCAYDDVRDVDPSWPPADRVERLLLPCGADFDAFLSRLAGSPPELETVANLMVDGGFARAVPVTAASSASSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2W8</accession>
    <name>Q9F2W8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4593</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628755.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974354.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4593"/>
    <dbReference type="GeneID" id="1100033"/>
    <dbReference type="KEGG" id="sco:SCO4593"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4665"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_11"/>
    <dbReference type="InParanoid" id="Q9F2W8"/>
    <dbReference type="OMA" id="NGWYHEN"/>
    <dbReference type="PhylomeDB" id="Q9F2W8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="284" mass="29620" checksum="1671DB61564A6418" modified="2001-03-01" version="1">MSIVVTGATGHLGRHVVRQLLDKVPADQVTAVVRNRDKAADLADLGVRLAVADYNAPETFDSVFAADDRVLLISGNEFDKGRVRQHTVVIEAAKKAGVALLAYTSAPSSLKAALADDHRATEEVLVGSGVPYTLLRNGWYHENYTEQLAPVLEHGAVVQAAGEGRISSASRADYAAAAVAVLTGEGHENTAYELGGDEAWSFAEYAAELSRQTGREITYNPVSVEDYTGILTGAGVPGPLADVFAGVDAAIGKGELVVSTGDLSRLAGRPTTPLAEAVAVALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F374</accession>
    <name>Q9F374_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4414</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628582.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029637.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4414"/>
    <dbReference type="GeneID" id="1099854"/>
    <dbReference type="KEGG" id="sco:SCO4414"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4483"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_9_11"/>
    <dbReference type="InParanoid" id="Q9F374"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="PhylomeDB" id="Q9F374"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="34"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="46768" checksum="B99BB6DFC67E97D4" modified="2001-03-01" version="1">MTQTTDAAAAAAASEARPEPTRPGRPTRAHRAWWVAAVTFVTIIGAAAFRSLPGILIDPLHQEFGWSRGTIGAAVSVNLALYGLTAPFAAALMDRFGIRRVVAVALMVIALGSGLTVWMNSAWQLILCWGLLVGLGSGSMALAFAATVTNRWFTERRGLVTGVLTAASASGQLIFLPLLSWIVETYDWRPAAVTVALAALAVVPFVWLLLHDHPADVGQKPYGAKEFVPKPAPVPGAARRALTVLFAAVRTGPFWLLAGTFAICGASTNGLIQTHFVPAAHDHGMPITAAASLLAVIGVFDVAGTIASGWFTDRFEPRRLLAVYYALRGVSLLFLPMLLAPSVHPPMIFFIVFYGLDWVATVPPTLALCREHYGEDSAIVFGWVLASHQVGAALVAFLGGVARDRFGSYDVVWIASGALCAAAALMALVIRRRPVPVAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3F8</accession>
    <name>Q9F3F8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4543</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628706.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029721.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1099983"/>
    <dbReference type="KEGG" id="sco:SCO4543"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4615"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_3_11"/>
    <dbReference type="OMA" id="EHHATFL"/>
    <dbReference type="PhylomeDB" id="Q9F3F8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="31799" checksum="8709794CA1E14FA8" modified="2001-03-01" version="1">MAPRSRPTARQARLGTELRRLREAAGLKAREAAGLISSTSAQMSQVEAGFAGASEARVRRLAAHYACADEALVDALVTMATDRTQGWWEEFRGILPPVFLDVAELEHHATFLHEVVITHVPGLLQTPDYARAVFGYMVPELPDSELIPRVEHRLRRRAVIERDAPAAYETVVHEAALRIRVGDRGVWRAQLRRLLDESEREHVTVRVIPFDTDHYAGASAAMMHLGGPLPQLDTVLRDSPNGTAFLDAQSQLERFRTLFRKVEQASLDPRRTRDFIHHLAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3F9</accession>
    <name>Q9F3F9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628704.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029719.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4541"/>
    <dbReference type="GeneID" id="1099981"/>
    <dbReference type="KEGG" id="sco:SCO4541"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4613"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517692_0_0_11"/>
    <dbReference type="OMA" id="WEEIGDW"/>
    <dbReference type="PhylomeDB" id="Q9F3F9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029013">
        <property type="entry name" value="HP0062-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158414">
        <property type="entry name" value="SSF158414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="526" mass="57019" checksum="C8CE84813203FB64" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3K6</accession>
    <name>Q9F3K6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5259</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629405.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973711.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5259"/>
    <dbReference type="TCDB" id="3.A.1.3.24">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100700"/>
    <dbReference type="KEGG" id="sco:SCO5259"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5342"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_2_11"/>
    <dbReference type="InParanoid" id="Q9F3K6"/>
    <dbReference type="OMA" id="VFEYINL"/>
    <dbReference type="PhylomeDB" id="Q9F3K6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC05960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34428" checksum="982EB241AF5F9927" modified="2001-03-01" version="1">MTVDIDKTAGGPAGTPPTPPEAIKAIPVRHYGRYVSAVVAIALLAAVVYAFSQGKINWGAIPDYFFDDRVLTGMGKTLLITVLAMLIGVVGGILLAVMRLSKNPVTSSIAWFYIWFFRGTPVLVQLVVWFNLGLVFEYINLGPFYRDEWSDFMTPFLTALLGLGLNEAAYMAEICRAGLLAVDEGQTEAAHALGMSHTKTLRRIVVPQAMRVIVPPTGNEVINMLKTTSLVSVVQYAELFRVAQDIGQTSGAPAEMLFLAAAWYLLLTSVFSVGQYYLERYYARGSSRSLPPTPMQKIRANLFSLSNRSSTTGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3M5</accession>
    <name>Q9F3M5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7663</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631703.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031812.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7663"/>
    <dbReference type="GeneID" id="1103101"/>
    <dbReference type="KEGG" id="sco:SCO7663"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7782"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_11"/>
    <dbReference type="InParanoid" id="Q9F3M5"/>
    <dbReference type="OMA" id="MRTDSAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="10183" checksum="89C9200E8E28EB57" modified="2001-03-01" version="1">MTVVDEVRDAVCSIPAGAVASYGDVGQRVGVGARQVGRAMSLLDENVPWWRVVYTDGTPPSCHGGRAPVLLRDEGTPMRGARVDMTRARHHWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBJ8</accession>
    <name>Q9FBJ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629308.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973817.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5160"/>
    <dbReference type="GeneID" id="1100601"/>
    <dbReference type="KEGG" id="sco:SCO5160"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5243"/>
    <dbReference type="eggNOG" id="ENOG5030GNI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118602_0_0_11"/>
    <dbReference type="OMA" id="WMPWPLP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="22611" checksum="27837A735AE3DED9" modified="2001-03-01" version="1">MRGEPSCPKCGGRVRAPGLFADSWQCDLHGTVHPVQPVLPPSVEALGVVVHRTQVPLWMPWPLPVGWLFTGVACAGDDRSGGRATAVACSGPGPLGGIGELILVAEELGVGLGARYAGLDGPDPGPYLDVEKPPQVKVLAAGRPTPLWHVSGGPVDRAVFAGEALGMWLWAVVWPERSGLLMYEELVLTDLRDAGAEVDLVPCGALSPRLIEPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBL8</accession>
    <name>Q9FBL8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2018" name="Biochem. Biophys. Res. Commun." volume="499" first="577" last="583">
            <title>Structural and biochemical characterization of the type-II LOG protein from Streptomyces coelicolor A3.</title>
            <authorList>
                <person name="Seo H."/>
                <person name="Kim K.J."/>
            </authorList>
            <dbReference type="PubMed" id="29596827"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2018.03.193"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629288.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973837.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="PDB" id="5ZI9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=1-252"/>
    </dbReference>
    <dbReference type="PDBsum" id="5ZI9"/>
    <dbReference type="SMR" id="Q9FBL8"/>
    <dbReference type="STRING" id="100226.SCO5140"/>
    <dbReference type="GeneID" id="1100581"/>
    <dbReference type="KEGG" id="sco:SCO5140"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5223"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_4_11"/>
    <dbReference type="InParanoid" id="Q9FBL8"/>
    <dbReference type="OMA" id="MFVKYSQ"/>
    <dbReference type="PhylomeDB" id="Q9FBL8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5ZI9"/>
        </source>
    </evidence>
    <sequence length="252" mass="27452" checksum="30D1649F1555FBAB" modified="2001-03-01" version="1">MATGNPEGKKRPPEEQRLGPVLRRRGQVQESTTDQRLLDERAPTDWVHTDPWRVLRIQSEFIEGFGTLAELPPAISVFGSARTPADSPEYDAGVRLGRGLVEAGFAVITGGGPGAMEAANKGALEAKGTSVGLGIELPFEQGLNPYVDIGLNFRYFFVRKMMFVKYAQGFVVLPGGLGTLDELFEALTLVQTQKVTRFPIVLFGSEYWGGLVDWLRGTLVAQGKAAEKDLMLFHVTDDVDEAVALVSKEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBW9</accession>
    <name>Q9FBW9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7816</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7816"/>
    <dbReference type="GeneID" id="1103254"/>
    <dbReference type="KEGG" id="sco:SCO7816"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7927"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054750_6_0_11"/>
    <dbReference type="OMA" id="VQWLTGM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC03634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="24110" checksum="0ADE227CD888EB50" modified="2001-03-01" version="1">MLAGIVLFGASLQWMTGMGFALVAVPPLVLLLGPSEGVVLTNCASGIICLAGLAQGWRRVRVGAMVPLCTAAICTVPIGARLTATLPEPVLMTVMGALVTAAVLLVMYGARVPALRGRKGAVAAGGLGGLMNSAAGVGGPPISLYAINAGWTVREFVPNAFFYGVVVNIFSVAAHGPPHLDAERWVWVAGALTIGMMIGRTFSGRLPENRARWLVLALALAGGMLALGKGLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC17</accession>
    <name>Q9FC17_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7067</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972077.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7067"/>
    <dbReference type="GeneID" id="1102505"/>
    <dbReference type="KEGG" id="sco:SCO7067"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7172"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_1_4_11"/>
    <dbReference type="InParanoid" id="Q9FC17"/>
    <dbReference type="OMA" id="IDLETFW"/>
    <dbReference type="PhylomeDB" id="Q9FC17"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="20863" checksum="9097ACB1566D1438" modified="2001-03-01" version="1">MSLPHAILTALVEKPSSGLELTRRFDRSIGYFWSATHQQIYRELGKLEAQGLIRALPDQQPARGQKKSYEVLPAGRAELSRWTATPQDPKPLRDTMLLRLRAAAVVGTAGVEADLRRHLELHERQLAEYEEIERRDFPPGRDSPEDRLRHLVLRAGIDLETFWTQWLVHALAEFAELPGDEPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCC2</accession>
    <name>BIOA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="1">DAPA AT</shortName>
            <shortName evidence="1">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="1">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioA</name>
        <name type="ordered locus">SCO1245</name>
        <name type="ORF">2SCG1.20</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625533.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027665.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCC2"/>
    <dbReference type="SMR" id="Q9FCC2"/>
    <dbReference type="STRING" id="100226.SCO1245"/>
    <dbReference type="GeneID" id="1096668"/>
    <dbReference type="KEGG" id="sco:SCO1245"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1245"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_11"/>
    <dbReference type="InParanoid" id="Q9FCC2"/>
    <dbReference type="OMA" id="VAVKMCL"/>
    <dbReference type="PhylomeDB" id="Q9FCC2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000411125" description="Adenosylmethionine-8-amino-7-oxononanoate aminotransferase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="312"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <sequence length="428" mass="45915" checksum="C2C46DE731FF7922" modified="2001-03-01" version="1">MPDPALNVAELLDLDRRHVWHPYGPMPGRQDPLVVESASGVRLRPADGSGELVDGMSSWWSAIHGYNHPVLNAAAREQLERMSHVMFGGLTHEPAVRLAKLLVDMSPEGLEHVFLADSGSVSVEVAVKMCLQYWRSLGRPGKHRLLTWRGGYHGDTWQPMSVCDPEGGMHELWSGVLPRQVFADAPPAEYEETYADHLRSMVERHAGELAAVIVEPVVQGAGGMRFHSPAYLRVLREACDAHDVLLVFDEIATGFGRTGALFAAEHAAVTPDVMCVGKALTGGYLTMAATLCTSRVAEGISRGEVPVLAHGPTFMGNPLAAAVACASIGLLLGQDWLAEVKRIETGLGEGLAPAAGLPGVRDVRVLGAIGVVQLDHAVDMRAATKAAVREGVWLRPFRDLVYTMPPYVTGDADVARIARAVCAAAREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCJ1</accession>
    <name>Q9FCJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5197</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629345.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030111.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5197"/>
    <dbReference type="GeneID" id="1100638"/>
    <dbReference type="KEGG" id="sco:SCO5197"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5280"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057502_2_0_11"/>
    <dbReference type="InParanoid" id="Q9FCJ1"/>
    <dbReference type="OMA" id="QVTPDKY"/>
    <dbReference type="PhylomeDB" id="Q9FCJ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="251" mass="27316" checksum="8E329CDDC326CF27" modified="2001-03-01" version="1">MQSPIFAYNDQQTQEAWSLQNKHMLRVALTGHDDVLARKGTMVAYQGLVEFDAEYQSNSQSRSRAHTGEGLDLMRCHGQGTVYFSNLAQCVHVVDVDQDGLTVDSSYVLAMDSNLHHEVIAVDSLYGISGSGKYQLNITGRGKVALMTSGSPLFMQVTPDKYVNCDADAIVAWSTGLRVQMQAQTHSSGVWRRRGNTGEGWELSFMGSGFALVQPSELLPPQNAQVGQGLAAQYGMGQHGARGQSQGNVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3P9</accession>
    <name>Q9K3P9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1099</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625393.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027574.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1099"/>
    <dbReference type="TCDB" id="2.A.85.8.1">
        <property type="family name" value="the aromatic acid exporter (arae) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1096522"/>
    <dbReference type="KEGG" id="sco:SCO1099"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1096"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020865_2_0_11"/>
    <dbReference type="OMA" id="LDLAMYT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="577" mass="59463" checksum="416D75D8AD8A90E7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K410</accession>
    <name>Q9K410_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1323</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625608.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027720.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1323"/>
    <dbReference type="GeneID" id="1096746"/>
    <dbReference type="KEGG" id="sco:SCO1323"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1327"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_4_2_11"/>
    <dbReference type="InParanoid" id="Q9K410"/>
    <dbReference type="OMA" id="VGPWFPL"/>
    <dbReference type="PhylomeDB" id="Q9K410"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB95780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="26264" checksum="78E4D6F4EE7DCFDD" modified="2000-10-01" version="1">MLDATTRSGGTATVSPRTAAAELAVAAAGPVAPTGFAARVTRVLLSPWSRLSLLVALLVSAATTVVLFQPQQLLTNGWPPQLGGAAAAVAYAVAYGLCTVAFVPRPLLNLAAGALFGSQLGLASALAGTVLGAGVAFCLGRVLGQEALRPLLRGKWLKAADGQLSRHGFRTMLAMRLFPGVPFAASNYCAAVSRMGLLPFLLATGLGSVPNTAAYVVAGARASTPTSPAFLIALACIALPGLAGAVVAWRKRHRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXH9</accession>
    <name>Q9KXH9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2341</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626588.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976463.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2341"/>
    <dbReference type="GeneID" id="1097775"/>
    <dbReference type="KEGG" id="sco:SCO2341"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2379"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093861_0_0_11"/>
    <dbReference type="OMA" id="LEGQWNR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="187" mass="20133" checksum="559B6151680FD8EC" modified="2000-10-01" version="1">MSDMTGKRGTPTEPRTPTEARPLAEPGTAAGESAAPEPGVIPERGTSAGPGATTEARTRTPTEARTPTEPRTLTEPRATPEPGVTGETAPVAARSLLPPGESDRLGERLHHAVAGFVDAPRASVEEADRVLEEIAARFADAVAHRRRTLRTSWQEADKDRGTPSTDTEQLRLALRDYRELADRLMRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-01-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXN1</accession>
    <accession>B5MG06</accession>
    <name>MQND_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="1">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnD</name>
        <name type="ordered locus">SCO4326</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2008" name="Science" volume="321" first="1670" last="1673">
            <title>An alternative menaquinone biosynthetic pathway operating in microorganisms.</title>
            <authorList>
                <person name="Hiratsuka T."/>
                <person name="Furihata K."/>
                <person name="Ishikawa J."/>
                <person name="Yamashita H."/>
                <person name="Itoh N."/>
                <person name="Seto H."/>
                <person name="Dairi T."/>
            </authorList>
            <dbReference type="PubMed" id="18801996"/>
            <dbReference type="DOI" id="10.1126/science.1160446"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>ROLE IN MENAQUINONE BIOSYNTHESIS</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>PATHWAY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cells lacking this gene require menaquinone-4 (MK 4) for their growth, and accumulate cyclic DHFL.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AB447891">
        <property type="protein sequence ID" value="BAG71677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628497.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974649.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXN1"/>
    <dbReference type="SMR" id="Q9KXN1"/>
    <dbReference type="STRING" id="100226.SCO4326"/>
    <dbReference type="GeneID" id="1099766"/>
    <dbReference type="KEGG" id="sco:SCO4326"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4395"/>
    <dbReference type="eggNOG" id="COG2107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070326_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXN1"/>
    <dbReference type="OMA" id="RGCGPLV"/>
    <dbReference type="PhylomeDB" id="Q9KXN1"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-14867"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000425127" description="1,4-dihydroxy-6-naphtoate synthase">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18801996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="18801996"/>
        </source>
    </evidence>
    <sequence length="282" mass="30054" checksum="99DAB54228CBC749" modified="2000-10-01" version="1">MSADTLQIAYSPCPNDTFVFDALAHGRVPGAPALDVTFADIDITNGMAERGELDVLKVSYAVLPYVLDDWALLPCGGALGRGCGPLVLTREADADLRGRTVAVPSETSTAYLLFRLWAADTVPGGVGEIVVMPFHEIMPAVRDGKVDAGLVIHEARFTYQNYGLHKLADMGEHWEHTTGLPIPLGAIIARRSLGAPALTRLADAVRASVRAAWDDPEASRPYVMEHAQEMDPAVADQHIGLYVNEFTADLGEDGYAAIRGLLTRAAAEGLVPALGPDALAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY23</accession>
    <name>Q9KY23_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2367</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626614.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976437.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2367"/>
    <dbReference type="GeneID" id="1097801"/>
    <dbReference type="KEGG" id="sco:SCO2367"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2406"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KY23"/>
    <dbReference type="OMA" id="CDKIVFP"/>
    <dbReference type="PhylomeDB" id="Q9KY23"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="191" mass="20414" checksum="C280293C548F3988" modified="2000-10-01" version="1">MGVTLAKGGNVSLSKAAPNLTQVLVGLGWDARSTTGAPFDLDASALVCSSGRVLGDEWFVFYNQLKSPDGSIEHTGDNLTGEGDGDDESLLVDLSKVPAHCDKIVFPVSIHMADERGQTFGQVSNAFIRVVNQADGQELARYDLSEDASTETAMIFGELYRYQGEWKFRAVGQGYASGLRGIALDFGVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYB4</accession>
    <name>Q9KYB4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MobC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6919</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630986.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6919"/>
    <dbReference type="GeneID" id="1102357"/>
    <dbReference type="KEGG" id="sco:SCO6919"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7026"/>
    <dbReference type="eggNOG" id="ENOG502ZPU4">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_114559_0_0_11"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18460" checksum="6980D35473A5A69B" modified="2000-10-01" version="1">MSGVSKGSPATGGPGLVRRRGTPDEEAATEGGSQPAGTQDKPEQPRTRRRTYQRRQRPHVRNTRFSDDELHLVTAGAQAAGLTLAGFLARAALSAARDLERTASAVADEREVIAEFFAARRHLGHIGNNLNQLARAVNAGARPDELDVVIAATDRAVQRVQRATDRLLHQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYX0</accession>
    <name>LPQB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein LpqB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpqB</name>
        <name type="ordered locus">SCO3011</name>
        <name type="ORF">SCE33.13c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpqB lipoprotein family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028714.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KYX0"/>
    <dbReference type="STRING" id="100226.SCO3011"/>
    <dbReference type="PRIDE" id="Q9KYX0"/>
    <dbReference type="GeneID" id="1098444"/>
    <dbReference type="KEGG" id="sco:SCO3011"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3070"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032207_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KYX0"/>
    <dbReference type="OMA" id="CASMPDS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023959">
        <property type="entry name" value="Lipoprotein_LpqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000286730" description="Lipoprotein LpqB">
        <location>
            <begin position="30"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="615" mass="65318" checksum="93FFDB97F96FD396" modified="2000-10-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ54</accession>
    <name>Q9KZ54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7077</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631139.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031418.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102515"/>
    <dbReference type="KEGG" id="sco:SCO7077"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7183"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_4_1_11"/>
    <dbReference type="InParanoid" id="Q9KZ54"/>
    <dbReference type="OMA" id="FGIVVND"/>
    <dbReference type="PhylomeDB" id="Q9KZ54"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="211"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="572"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB89749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="716" mass="75451" checksum="E5D2C76146301BB7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZC0</accession>
    <name>Q9KZC0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6969</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631035.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031344.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6969"/>
    <dbReference type="TCDB" id="2.A.102.2.5">
        <property type="family name" value="the 4-toluene sulfonate uptake permease (tsup) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1102407"/>
    <dbReference type="KEGG" id="sco:SCO6969"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054750_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZC0"/>
    <dbReference type="OMA" id="YRRHAHW"/>
    <dbReference type="PhylomeDB" id="Q9KZC0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="27370" checksum="E941FF5309BA0108" modified="2000-10-01" version="1">MDTMTLWHLTGWEFAALAFAALLVGFSKTAVSGANTVSLAIFAAVLPARASTGILLPVLIAGDVLAVLTYRRHAHWPTLWRLFPAVGVGVVVGTLFLVWADDAVVRTSIGVILLFMAAVTVWRRRRADADGQPDEVTSRTGRVKARSYGVLGGFTTMVANAGGPVMSMYLLSAGFRKLGFLGTSAFFFLIVNVSKLPFSAGLGLIDGHSLLLDAALVVFVVPGAFLGKWAVDRINQRLFERLVIAATIVGGLQLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZD6</accession>
    <name>Q9KZD6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6953</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631019.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031335.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6953"/>
    <dbReference type="GeneID" id="1102391"/>
    <dbReference type="KEGG" id="sco:SCO6953"/>
    <dbReference type="eggNOG" id="ENOG503347U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033217_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="525" mass="57338" checksum="4A7BE97C8CAFBB24" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZE5</accession>
    <accession>Q7BB71</accession>
    <name>Q9KZE5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC-transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ecaA</name>
        <name evidence="11" type="ordered locus">SCO7008</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="3183" last="3192">
            <title>Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays.</title>
            <authorList>
                <person name="Huang J."/>
                <person name="Lih C.J."/>
                <person name="Pan K.H."/>
                <person name="Cohen S.N."/>
            </authorList>
            <dbReference type="PubMed" id="11731481"/>
            <dbReference type="DOI" id="10.1101/gad.943401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">A3</strain>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF425987">
        <property type="protein sequence ID" value="AAM78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631073.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031376.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7008"/>
    <dbReference type="TCDB" id="3.A.1.106.9">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1102446"/>
    <dbReference type="KEGG" id="sco:SCO7008"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7110"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="OMA" id="ERQRMTI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="45"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="378"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="412"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAM78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="624" mass="67273" checksum="112EB8F52199FABD" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZH2</accession>
    <name>Q9KZH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable ABC transport protein, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6980</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631045.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6980"/>
    <dbReference type="GeneID" id="1102418"/>
    <dbReference type="KEGG" id="sco:SCO6980"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7079"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OMA" id="DWFKAFL"/>
    <dbReference type="PhylomeDB" id="Q9KZH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="37848" checksum="6D393D09BDA40713" modified="2000-10-01" version="1">MMSMAQQAEPAVTTPPAPGPKQTDGRTRERSVALRVLARPEVGVFLGAVAVFVFFLIAAPTLRDGGSMATVLYQSSTIGIMALPVALLMIGGEFDLSAGVAVVTSALTAGMLSYQLTMNVWMGVVVALVASLAVGAFNGWVLVKTGLPSFLVTLATFLVLQGVNLAVTKLVTGNVATDDISDMDGFDQAKALFASSFDVGGVEVKITVVWWLVFAALATWVLLRTKYGNWIFAVGGSQESARAVGVPVTFTKITLFMLVGFGAWFVGMHQLFSFNTVQSGEGVGQELIYIAAAVIGGCLLTGGYGSAIGPVFGAFMFGMVNQGIVFAGWNPDWFKAFLGVMLLGAVLINLYVRRAATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0J0</accession>
    <name>Q9L0J0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4675</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628835.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974288.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4675"/>
    <dbReference type="GeneID" id="1100116"/>
    <dbReference type="KEGG" id="sco:SCO4675"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4747"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075818_0_0_11"/>
    <dbReference type="OMA" id="ASWAYYV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB81866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="302" mass="33197" checksum="F9AD5CD763E411A8" modified="2000-10-01" version="1">MVSSSHEAMHRIFQHDPGLFSRVTHFLGIDLPRPIGATALPTDLTEASPVERRVDTLLRFETAERGPFLLAVEAQGKKDPDKPASWAYYVSYLWTKYRLPTALLVVCQDHATAKWAQRAVTSGPPELPTLTLRPVVAGPHNMPVITDPDEARADLVLASLAAITHAAEPVVNAILKALSTALSDAPEDIAAPIVEFTAHGLGNRPARHLWRNLVAVDLSFYKSYISEEIRDEGREQGREQGREQGRAQQGAQDVLLVLEQRGLDIPDGVRTRITECGDPEVLRHWLARAVTASSAEAVFESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0U3</accession>
    <name>Q9L0U3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bifunctional protein (Ketoreductase/3-oxoacyl-[acyl-carrier protein] reductase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4501</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628665.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029697.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4501"/>
    <dbReference type="GeneID" id="1099941"/>
    <dbReference type="KEGG" id="sco:SCO4501"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4573"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047208_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0U3"/>
    <dbReference type="OMA" id="LYEFFTP"/>
    <dbReference type="PhylomeDB" id="Q9L0U3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB77292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="430" mass="43535" checksum="90623C0558B18F8F" modified="2000-10-01" version="1">MADRYLSFTGTAPGRFLTRRLGLPQPAALRRDALDGGLLHLTAGKTDLDLAPVLARTGLPRDEDGRPAAVVLDATGVRDVDALAEVHAALHPVVRSVAASGRVVVLGAPLDPADHHQAAVQQALEGFTRSLGKEIGRGRTVNLVRLTDAAPAESTLRFLLSPASAYVSGQVIEVGAAGGGAAPDDWALPLAGRTALVTGAARGIGAAVAETLAGQGAQVVVLDVPQAEEAARRAAERLGGTALALDITAADAGERIAAALPGGLDVLVHNAGITRDRRLVNMPADRWSSVLDVNLASVLRTTDALLAAGAVNRGGRIVATASIAGLAGNAGQTNYGASKAGIVGLVRSLAPRALAGHGVTVNAVAPGFIETRMTAAVPLFIREAGRRMNSLAQGGLPVDVAETTAWLAHPASGAVNGQVVRVCGQSLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2L0</accession>
    <name>Q9L2L0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0693</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625000.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0693"/>
    <dbReference type="GeneID" id="1096116"/>
    <dbReference type="KEGG" id="sco:SCO0693"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.679"/>
    <dbReference type="eggNOG" id="ENOG502ZD2N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139810_1_0_11"/>
    <dbReference type="OMA" id="IYTVSPV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB69665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12215" checksum="52508539262B595A" modified="2000-10-01" version="1">MHRAPEEGAVDTTTVIVVAVLLAALVLAAAVAVLVRLVRTRRDLRRAGLPTGPRWVFWGAVLYLVLPADLLPDPVYLDDIGVLLLALRSARGATGGRLGPAERRRTTGPPGDYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD48</accession>
    <name>Q9RD48_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0635</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624945.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027263.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0635"/>
    <dbReference type="ESTHER" id="strco-SCF56.19">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1096058"/>
    <dbReference type="KEGG" id="sco:SCO0635"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.618"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081587_1_0_11"/>
    <dbReference type="OMA" id="WWHRITA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="31166" checksum="412FF60F1F9428D1" modified="2000-05-01" version="1">MVRSRGAGGLEGAADRFGDHRSGGGAATDHPLRGEEGSGREGAGMGTQDDPSRDRALRVRHRPPRTRAAVLVLHGGRAESRSAARPWQLAALRMHPFLRALGAATGHDDVLLGQVRYRNRGWNGAAEDPLRDARRALAELHGLVGDVPVVLLGHSMGGRAALRAADADPVRGVVALAPWCPPGEPVAQLRDRALLVLHGSRDRVTDPGESAAYVSRARAAGARAGLLLLENGDHAMLRHHARWHRTATAAVAHLLAPEAAPCELFARALSAAAPPVLRSAPPAASDAARGPVREPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDF1</accession>
    <name>Q9RDF1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2540</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626778.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028415.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2540"/>
    <dbReference type="GeneID" id="1097974"/>
    <dbReference type="KEGG" id="sco:SCO2540"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2585"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RDF1"/>
    <dbReference type="OMA" id="VPGWHSP"/>
    <dbReference type="PhylomeDB" id="Q9RDF1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="83"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="396" mass="41801" checksum="494A83C3153F2A20" modified="2000-05-01" version="1">MTASTVSTDVPGATDVPVMPADERTHRHVPPEGSHRHPQVDPLAALRTPQDPPWDVYLTGTVFLDVIFTGLDSAPVRGTESWARGMGSSPGGIANMATALARLGLRTSLAAAFGDDHYGDYCWDALAQGEGIDLSPSRTVPGWHSPVTVSMAYEGERTMVSHGHEPPPEEPSPDCPPRARAAVASLTPGVRAPWIAQAAARGTRVFADVGWDDTGAWDLAGLPDLAHCEAFLPNAEEAMRYTGATCPRAAAHALTEHVPLAVVTLGADGAYAVDRRTGESAEVPAIEVEALDPTGAGDVFVAGFVTGTLAGWPLADRLAFAGLTAALSVQEFGGSLAAPGWCEIATWWRKVQSVESQDPTALRRYAFLADLVPDAQPGSWPLRRAVPTIGFRRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDH0</accession>
    <name>Q9RDH0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2757</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626988.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028565.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2757"/>
    <dbReference type="GeneID" id="1098191"/>
    <dbReference type="KEGG" id="sco:SCO2757"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2813"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="InParanoid" id="Q9RDH0"/>
    <dbReference type="OMA" id="ERWICQP"/>
    <dbReference type="PhylomeDB" id="Q9RDH0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176874" evidence="2">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB66296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="33481" checksum="8F577D05F5EAAB37" modified="2000-05-01" version="1">MLDLQRLRALHAVSVHGTVGAAAAALGFTPSAVSQQIAKLERETRTVLLEREGRGVRLTDEAWQLVEAAAELLAIVERAETRLEERRGVPSGRLTIAAFASAARGLLPSVLADLAVRHPGLDARLTEVDPHLSVDLVAKGAVDLVVAHDWDIAPLPAPAGVEQAPVGEDLCDLLVPEGHRFAGRTAVRRDELGGERWICQPPGRVCHDWLMRTLRGAGHEPDIVHQADENPTLVALVAAGLGVALIPRLGRGPLPAGVVEVPLDPMPVRRLYALWRTGAARRPAIAETVRTLRAHWPTVAARTGPPRQAAAHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-02-28" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDL7</accession>
    <name>Y2569_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>DegV domain-containing protein SCO2569</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2569</name>
        <name type="ORF">SCC123.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626807.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976234.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RDL7"/>
    <dbReference type="SMR" id="Q9RDL7"/>
    <dbReference type="STRING" id="100226.SCO2569"/>
    <dbReference type="GeneID" id="1098003"/>
    <dbReference type="KEGG" id="sco:SCO2569"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2614"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RDL7"/>
    <dbReference type="OMA" id="MALGFCA"/>
    <dbReference type="PhylomeDB" id="Q9RDL7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000209793" description="DegV domain-containing protein SCO2569">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DegV" evidence="3">
        <location>
            <begin position="5"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>hexadecanoate</name>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>hexadecanoate</name>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9X1H9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00815"/>
        </source>
    </evidence>
    <sequence length="281" mass="29185" checksum="B6E228A03C004AD3" modified="2000-05-01" version="1">MSRHVAIVTDSTAYLPARAMERHGITAVPLTVVLGDRALEEGTEISTRSLAQALQKRRPVTTSRPNPELFAETYRRIAESGADGIVSLHLSAELSGTHDAAVVAAREAPVPVRVVDTGMIAMALGFCALAAAETAEAGGTVDEAVTAAEKRAAGTSAYFYVDTLDYLRRGGRIGAAQALFGSALAVKPLLQLEGGRIEPLEKVRTASKAIARLEEIAADRAGGAPVDIAVHHLAAPDRASALADRLRDRVPGLADLHVSEVGAVIGAHTGPGLLGVVVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI32</accession>
    <name>Q9RI32_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="5">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO0216</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="5"/>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37045">
        <property type="entry name" value="T37045"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624549.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026932.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0216"/>
    <dbReference type="GeneID" id="1095640"/>
    <dbReference type="KEGG" id="sco:SCO0216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.190"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_11"/>
    <dbReference type="InParanoid" id="Q9RI32"/>
    <dbReference type="OMA" id="FAFDWQR"/>
    <dbReference type="PhylomeDB" id="Q9RI32"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
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        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
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        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
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        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137116" checksum="442EABDDF2098629" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI66</accession>
    <name>Q9RI66_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0111</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CAB52925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="25347" checksum="B765C51D276775AB" modified="2000-05-01" version="1">MSNAFHNKVAVVTGGSAGIGHATARKIAEGGGTVYITGRDQDAATAAAADIPGDVIGVRADSRSTDDLGRLFAQVKRRSGRLDVLVVNAAAIATAPLGTITEDVIRTVFDVNITGTIMAVQKALPLLADGGVIVLTGSMAAHKASRGRSLYAASKAGVRALARTWALELTPRGIRVNVVSPGPTDTPGIAQLAATAEEREALIATMGTGTPMTRAGTAEEVAAVISFVASDAASHVNGADYQVDGGYGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIT7</accession>
    <name>Q9RIT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase/reductase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0970</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO0970"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.967"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RIT7"/>
    <dbReference type="OMA" id="ARVWVSE"/>
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    <dbReference type="Proteomes" id="UP000001973">
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="26037" checksum="8BADAAA6ED5B7B22" modified="2000-05-01" version="1">MGKLDGKVAVITGGSTGLALAGAKLFVAEGAYVFIQARRQEALDEAVKLIGRNVTAVQGDASDLDDLERLYDTVKQEKGSIDVLWASAGFGEPGVLGEITEEQFERSFSLNARGTLFTVQKALPLINDHGSILMTGSNASLGAFPGWSLYAGSKAVQQAWARVWLNELRDRKIRVNVLTPGQVATAKQEELFDEATRASFESLIPRGTMGRPEEIASIALFLASDDSSYVNGLELVADGGTTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIZ5</accession>
    <name>Q9RIZ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0170</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36952">
        <property type="entry name" value="T36952"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624506.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978707.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0170"/>
    <dbReference type="GeneID" id="1095594"/>
    <dbReference type="KEGG" id="sco:SCO0170"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.143"/>
    <dbReference type="eggNOG" id="COG3448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RIZ5"/>
    <dbReference type="OMA" id="ECRSTAQ"/>
    <dbReference type="PhylomeDB" id="Q9RIZ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="82"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB53137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="24057" checksum="D22665A14ECF6A4B" modified="2000-05-01" version="1">MTRRVIALAGGATFKDIVRTMETQLISALPVIDSGSHVIGVVSEADVLRKEEFRDSDQLRGPRSRPPGALVKARAVTAEDLMTAPAVTVHPKAPVARAARLMARRRVKRLPVVDDEGVLQGIVSRADLLRVFLRSDPDIAEEVRREIVGGRFPEGLGSVRVEVHEGVVTLTGRVPDTSLVPLAERLVRSVEGVVDVRCVLTGPRHRMTGESEKAGAAAHRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ56</accession>
    <name>Q9RJ56_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO1652</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625927.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027902.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1652"/>
    <dbReference type="GeneID" id="1097083"/>
    <dbReference type="KEGG" id="sco:SCO1652"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1667"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ56"/>
    <dbReference type="OMA" id="ITWVFGG"/>
    <dbReference type="PhylomeDB" id="Q9RJ56"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="374" mass="39796" checksum="24F9B18BC422C2F8" modified="2000-05-01" version="1">MGRPFGVPVYVAPSWFLVAVLITWVFGGQLDRVLPELGAARYLVSLFFAVAFYASVLVHELAHTVAALRFKLPVRRIQLQFFGGVSEIEKEAETPGREFVLAFVGPLLSLVLSGVFYAALLPVEPDSVAGVLLAGLMVSNLIVAVFNLLPGLPLDGGRMLRAVVWKLTGKPMSGTIAAAWVGRALAIAVLIGLPLLTQSLGSDAADDVGMDTVMDALLAAILAAIIWTGAGNSLRMARLREHLPELRARALTRRAVPVQADTPLSEALRRANASGARALVVVDGEGTPASLVREAAIVGVPEHRRPWVPVSTLAQDLTDGMRVSAELSGEELLDVLRANPATEYLVVEETGEIYGVLSAADVERAFVKAMARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ74</accession>
    <name>Q9RJ74_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1627</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625902.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027892.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1627"/>
    <dbReference type="GeneID" id="1097058"/>
    <dbReference type="KEGG" id="sco:SCO1627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1642"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ74"/>
    <dbReference type="OMA" id="GVDDNYG"/>
    <dbReference type="PhylomeDB" id="Q9RJ74"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="176" mass="19278" checksum="E0D0345C5E6F9FE1" modified="2000-05-01" version="1">MGGFGVGKTTMVGSVSEIRPLTTEETMTQAGIGVDDNYGSASKTATTVAMDFGRISITDELVLYLFGTPGQERFWFLWNGLFEGALGAVVLVDTRRLEVSFDVMGRLEERGVPFVVAVNTFPDAPRYPVAELRTALDLPEEIPILDCDVRRRASSRDVLMTLMRLLHSLAMKGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJJ5</accession>
    <name>Q9RJJ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0393</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978472.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0393"/>
    <dbReference type="GeneID" id="1095816"/>
    <dbReference type="KEGG" id="sco:SCO0393"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.369"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_10_0_11"/>
    <dbReference type="InParanoid" id="Q9RJJ5"/>
    <dbReference type="OMA" id="YGAHHIK"/>
    <dbReference type="PhylomeDB" id="Q9RJJ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB58334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="30011" checksum="993D4102471E7692" modified="2000-05-01" version="1">MKVVLFCGGYGMRMREGALDDVPKPMAMVGPRPLIWHVMRYYAHFGHKEFILCLGYGAHHIKDFFLNYEETTSNDFVLRGGRTELLSADIADWTITFAQTGIESPIGERLRRVRHHLDGDEMFLANYADVLTDAPLPEMIDSFARRDAGASMMVVPPQSSFHCVDLGEDGLVGGITAVSDLPLWENGGYFVLRQEVFDHIPENGDLVADGCTQLAKRGRLVAHQHRGFWKPTDTVKERAALDAAYARGERPWAVWERDGAMSGAGVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ9</accession>
    <name>Q9RJQ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0581</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624893.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978280.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0581"/>
    <dbReference type="GeneID" id="1096004"/>
    <dbReference type="KEGG" id="sco:SCO0581"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.562"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJQ9"/>
    <dbReference type="OMA" id="VIVCWFN"/>
    <dbReference type="PhylomeDB" id="Q9RJQ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031224">
        <property type="term" value="C:intrinsic component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="455" mass="49419" checksum="2EB58F7763E9B5E4" modified="2000-05-01" version="1">MGAQAPSAAVERTAIKKVSVRLVPFVALMFFVNYLDRTAVSFAEPNGMGQDLALTAAQFGFASGIFFLGYIVLEVPSNMALHRFGARRWLARIMVTWGIVSLLFTWVSSSGQLYTLRFLLGVAEAGFFPGAILFLSQWVPSRHRTKILGLFYLAQPLTTVFGAPLAGWLIGRHGLFGLEGWRVMFLFVSLPAIVLGVVAWFYLIDKPADAKWLTPAERDWLTTELAAENAQKTGHEGKHAKGDLRKAFGSGRVWTLAAVYFGFVYGLYALAFFLPTIINGFQDQYDTTFSVMDKAWITAIPYLPAAIVLFFWTRHATRHGTRTWHVAGPAVVGGVSIPLALYMGSPTATVAVITVTACAIFAALPVFWSVPSRFLTGAAAAAGIALINTAGNVAGFASSYITGWLKDWSGAYYVPLYLVGFFMLLSAALMILLAARNGTGEPATAPEPQAEEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK28</accession>
    <name>Q9RK28_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0688</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624996.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027296.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0688"/>
    <dbReference type="GeneID" id="1096111"/>
    <dbReference type="KEGG" id="sco:SCO0688"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.674"/>
    <dbReference type="eggNOG" id="ENOG5033SG9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_725424_0_0_11"/>
    <dbReference type="OMA" id="HEAMTPD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="390" mass="42350" checksum="A21C43451BE4AB92" modified="2000-05-01" version="1">MPTSSTARPTHPPTLWAARGRHVGSAAEDTVRHRLRRLKDDHVVDDFLEPPDDPAAEPPSAGTPGPRILEARWKAAGTVTVRARLILEPASAGGQEWTLLAEAEEAWDLAWPSPATVFWPDDPDVTWDRDAATGLRLRGINTLPDDDKAVRRLLKEAGRSPWNIHVVVHEAMTPDHRGRVPLAQRLPPGLRHRVVEHRAAPQQLRVVNWALEDFGVQVPRGGAVVLPGTPAPADYAAGDFSVRTVFLDGSEPTALIAAVTSFAALPRPLPDDAVAALASLREDWRLLTLEEELERERKLVKMYAEALEAMTQSRDLYREAAERAAEALAVYRESAAAAPAGPPPSQAPPASPLRGLTRTLERFRGSARTPRPDAADRGTTEPPGSSAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK34</accession>
    <name>Q9RK34_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0682</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB60463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624990.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0682"/>
    <dbReference type="GeneID" id="1096105"/>
    <dbReference type="KEGG" id="sco:SCO0682"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.668"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139202_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RK34"/>
    <dbReference type="OMA" id="KMRTMEH"/>
    <dbReference type="PhylomeDB" id="Q9RK34"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB60463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13435" checksum="8E473FE8B94DEDC9" modified="2000-05-01" version="1">MANLETSLKECLSSIDGATAAALVDYTSGMALGTLGGGKEFNLEVAAAGNTDVVRSKLRTMEHLGLKEEIEDILITLSSQYHMIRLLKGRGGNGLFLYLVLDASRANLAMARHQLRRIESELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK35</accession>
    <name>Q9RK35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ferredoxin/ferredoxin-NADP reductase (Putative secreted protein)</fullName>
        </submittedName>
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    <gene>
        <name evidence="10" type="ordered locus">SCO0681</name>
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    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
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        <property type="protein sequence ID" value="CAB60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624989.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RK35"/>
    <dbReference type="STRING" id="100226.SCO0681"/>
    <dbReference type="GeneID" id="1096104"/>
    <dbReference type="KEGG" id="sco:SCO0681"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.667"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024722_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RK35"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="PhylomeDB" id="Q9RK35"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="454" mass="49814" checksum="6BC1F37E3E1935E9" modified="2000-05-01" version="1">MPRPLRVAIVGSGPAGIYAADALLKSEVAADPGVSIDIFERMPAPFGLIRYGVAPDHPRIKGIITALHQVLDKPQIRLFGNVNYPTDVSLDDLRAFYDGVIFATGATADRDLSLPGIDLDGSYGAADFVAWYDGHPDFPRTWPLEAEKVAVLGVGNVALDIARVLAKTADELLPTEIPPNVYEGLKANKALEVHVFGRRGPAQAKFSPMELRELDHSPNIEVIVDPEDIDYDEGSIATRRGNKQADMVAKTLENWAIRDVGDRPHKLFLHFFESPAEILGEDGRVTGLRTERTELDGTGNVKGTGEFKDWDVQAVYRAVGYLSDQLPKLPWDLETGTVPDAGGRVVQESGEHLQSTYVTGWIRRGPIGLIGHTKGDANETVSNLLDDYANGRLQTPSSPAPEAVDAFLAERNVRFTTWDGWYRLDAAEKAQGEPHGRERVKYVEREDMLRESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKE0</accession>
    <name>Q9RKE0_STRCO</name>
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        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3498</name>
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    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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    <dbReference type="RefSeq" id="WP_011029034.1">
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    </dbReference>
    <dbReference type="STRING" id="100226.SCO3498"/>
    <dbReference type="GeneID" id="1098934"/>
    <dbReference type="KEGG" id="sco:SCO3498"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3556"/>
    <dbReference type="eggNOG" id="COG3420">
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    <dbReference type="HOGENOM" id="CLU_046127_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKE0"/>
    <dbReference type="PhylomeDB" id="Q9RKE0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
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        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
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        <property type="entry name" value="DUF1565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
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    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
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    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176933" evidence="2">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="3">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="358" mass="37675" checksum="50AC59595FAF265A" modified="2000-05-01" version="1">MRLIRYIASAAALLAVTGTSAPVASAAEPRGGHDIYVSPRGSDTNPGTRQAPFAGIQRALDVAGPRSTVHLAPGRYLQDFVSRSPGVTLTGPPSAVVQGSGEGRAVGEIQHDRVRLTGFTIDGLVGDATEKSDYRKKLLYVMGLTPGDGVDGLRITRMTFRNAGEECVRLRYLVTGAEVAHNRITGCGVWDFRFADGGKVGEGIYLGTAPEQQGLNGAPDDRPDVSRDNWIHHNRIDTQGNECVDIKENSTANLVERNDCTGQRDPNSAGLDARGSGNTFRANRSYDNVGAGIRVGGDTPADGTGNTIEDNVLLSNSAGGIKFEATPQGRVCGNTLAGNTGGDATGTYGNEYEPSRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKH2</accession>
    <name>Q9RKH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO3460</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627664.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029001.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3460"/>
    <dbReference type="GeneID" id="1098897"/>
    <dbReference type="KEGG" id="sco:SCO3460"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3520"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKH2"/>
    <dbReference type="OMA" id="PVDIQMR"/>
    <dbReference type="PhylomeDB" id="Q9RKH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="40"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="370"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="7">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB61868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="505" mass="53282" checksum="858B9A9E56C88C21" modified="2000-05-01" version="1">MEAGKGRNRLRQRVPLPSHARAPAIPRRRTDREFRAMKRYDLVVIGGGSAGLTAARTAGRLGARTLLVERDRLGGDCLWTGCVPSKALLHVAADVQAARRATAYGLPPVTGPADLTAALAEVKRAIGAIEPHDSAEALAPYGVDVTHGAASFTGPGTLTAGEREVSFRYALIATGSSPALVPIPGLVESGPLTSDTVWELSELPHLLVVLGGGPIGCELGQAFARLGSQVTLVEAMDRLVPREEPRASQVLRERLQSEGVTVLTDYRAERVDADAVHGPGGPLPYDALLAVTGRRSHTHGLGLEAAGVELTDAGHIRTDGRLRTTNHRIYAAGDVTGRSAFTHLGGTQGGAAAVDALLGVRRPIDYRAAPRVTYTDPEIAGVGLTLDEAHAKYGDRARVHTLENDRVDRAVADGRTEGFTTLVLGPRGKIVGATVVSPRAGETVAHLAAAVRLGWTPSDYARTVHPYPTYADGPWHTALTDVYARLARGSGPIGALLKLRRGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKS8</accession>
    <name>Q9RKS8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6264</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAB60183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630364.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030779.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6264"/>
    <dbReference type="GeneID" id="1101705"/>
    <dbReference type="KEGG" id="sco:SCO6264"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6379"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="InParanoid" id="Q9RKS8"/>
    <dbReference type="OMA" id="CFPAAAY"/>
    <dbReference type="PhylomeDB" id="Q9RKS8"/>
    <dbReference type="BioCyc" id="MetaCyc:SCO6264-MON"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB60183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="27384" checksum="EE67C081DEB904CD" modified="2000-05-01" version="1">MRAHGTRYGRPLEGKTALVTGGSRGIGRGIALRLAADGALVAVHYGSSEAAARETVETIRSSGGQALAIRAELGVVGDAAALYAAFDAGMGEFGVPPEFDILVNNAGVSGSGRITEVTEEVFDRLVAVNVRAPLFLVQHGLKRLRDGGRIINISSAATRRAFPESIGYAMTKGAVDTLTLALARQLGERGITVNAVAPGFVETDMNARRRQTPEAAAALAAYSVFNRIGRPDDIADVVAFLASDDSRWITGQYVDATGGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKU6</accession>
    <name>Q9RKU6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator for glyoxylate bypass</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6246</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630346.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972681.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6246"/>
    <dbReference type="GeneID" id="1101687"/>
    <dbReference type="KEGG" id="sco:SCO6246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6360"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_3_11"/>
    <dbReference type="InParanoid" id="Q9RKU6"/>
    <dbReference type="OMA" id="RHSMRMF"/>
    <dbReference type="PhylomeDB" id="Q9RKU6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="81"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="270" mass="28423" checksum="1D9B3D689BADF824" modified="2000-05-01" version="1">MPTSSASTTDSARSATGGVQSLERAFDLLERMADAGGEVGLSELSASSGLPLPTIHRLMRTLVACGYVRQQPNRRYALGPRLIRLGESASRLLGTWARPHLARLVEETGETANMALLDGDEIVYVAQVPSKHSMRMFTEVGRRVLPHSTGVGKALLASFPADEVRALLGRTGMPAATDKTITTPDGFIAALEDVRRQGYAIDDNEQEIGVRCLAVPVPDSPTAAAISISGPAGRVTEAATDRIVPLLQQVAAELSEALLTSNGSNGNPAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL35</accession>
    <name>NPD1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent protein deacetylase 1</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Regulatory protein SIR2 homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobB1</name>
        <name type="ordered locus">SCO0452</name>
        <name type="ORF">SCF51A.30</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624772.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027127.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RL35"/>
    <dbReference type="SMR" id="Q9RL35"/>
    <dbReference type="STRING" id="100226.SCO0452"/>
    <dbReference type="GeneID" id="1095875"/>
    <dbReference type="KEGG" id="sco:SCO0452"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.430"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_2_11"/>
    <dbReference type="InParanoid" id="Q9RL35"/>
    <dbReference type="OMA" id="RRHYWAR"/>
    <dbReference type="PhylomeDB" id="Q9RL35"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000110359" description="NAD-dependent protein deacetylase 1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <sequence length="299" mass="31559" checksum="F5A96FAE58EEB838" modified="2000-05-01" version="1">MRMRPTLSWTPGADLPPGTTDLAPVADALRAGGVLVLSGAGISTESGIPDYRGEGGSLSRHTPMTYQDFTAHPEARRRYWARSHLGWRTFGRARPNAGHRSVAAFGRHGLLTGVITQNVDGLHQAAGSEGVVELHGSLDRVVCLSCGVLSPRRELARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVFFGENVPPRRVEHCRELVRGASSLLVLGSSLTVMSGLRFVRQAAEAGKPVLIVNRDATRGDRLAVTRVALPLGPALTTVADRLGLRVGDAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1R5</accession>
    <name>Q9S1R5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0226</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37141">
        <property type="entry name" value="T37141"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624558.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978642.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0226"/>
    <dbReference type="GeneID" id="1095650"/>
    <dbReference type="KEGG" id="sco:SCO0226"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.200"/>
    <dbReference type="eggNOG" id="ENOG5031EHZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184480_0_0_11"/>
    <dbReference type="OMA" id="YPSETAK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="25619" checksum="A4FEFB11CD014319" modified="2000-05-01" version="1">MLFEKESPELNSPVHLSLSGRPAIAVLALVGITAGVLIGRESLRTVVGCGAPDDRFPSRTAADWKAGADHVVVTRPTAERETNREEVAMGAVRYTVDRAVTLRKERVLWSAAAPRHELGSEFDMTAPGWSVYRNGKRVKGTAPEAPRLEIGHMYVLALRWEADQWVVLGEGAAVPFDDRVAGRGEWCGMVLSEDDFAKGERFSRRDDHSLEETVQGQGEAAISRELAKTGSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1T4</accession>
    <name>Q9S1T4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0058</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37122">
        <property type="entry name" value="T37122"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624412.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026814.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0058"/>
    <dbReference type="GeneID" id="1095489"/>
    <dbReference type="KEGG" id="sco:SCO0058"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.48"/>
    <dbReference type="HOGENOM" id="CLU_1155841_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="2">
        <location>
            <begin position="52"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="26698" checksum="0F25100F49EA0354" modified="2000-05-01" version="1">MLGKQVLPAAGVEEAVAVFRCACRTASHWSFPWAICPRTRVERPPRRRTPDRSRPRRRARAGHRSSSIDATARWGHASVARAQDILARRYRLECADAAFELLKTSSQQSNVKLHTLADAVVRTPAPDLDARSWRRRPPPAGRSQCGTWAPRPYSTRHPVRPSCRRAAGPPTASPLITVKGHVLGMVSSHHGHPLHGFSRLQLAALQQTGTDVGRWLSWHWDTVVLDALERLHVQAVGACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S234</accession>
    <name>Q9S234_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1766</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36869">
        <property type="entry name" value="T36869"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626037.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977058.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1766"/>
    <dbReference type="GeneID" id="1097197"/>
    <dbReference type="KEGG" id="sco:SCO1766"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1783"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_7_1_11"/>
    <dbReference type="InParanoid" id="Q9S234"/>
    <dbReference type="OMA" id="MTCLRAC"/>
    <dbReference type="PhylomeDB" id="Q9S234"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="36418" checksum="DEC7079DAF26885B" modified="2000-05-01" version="1">MTTTGTKRPATGALTGLALGDALGFPTEFNDVPAILAKCGPWREMALPRPAIVTDDTQMTLALGKGLRTAMDRGLLGPKRMERPVREEFVDWYQSPENNRAPGNTCLKACNLLKAPDRPWQDASQIHSKGCGANMRVAPVGLVPGLSDEQRAGAAQLQSALTHGHPTALAASDLTAHAVRLLAEGAEPTGLVGLLRSYAYDNRTRYHERWLGDLWSRAQDPTPEHFIARGWDECLAILDRLQEAVRTVSPETDPCLAVGEGWIAEEAMAAGLLCFLLFVDEPLTALRRGACTSGDSDSIACLAGAFAGAHLGADAWPADWADRIEYRGDLLALGALWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2L0</accession>
    <name>Q9S2L0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1993</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35738">
        <property type="entry name" value="T35738"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626254.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028084.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1993"/>
    <dbReference type="GeneID" id="1097427"/>
    <dbReference type="KEGG" id="sco:SCO1993"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2020"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204242_0_0_11"/>
    <dbReference type="OMA" id="AITPDGC"/>
    <dbReference type="PhylomeDB" id="Q9S2L0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="24847" checksum="71A132C80230A14A" modified="2000-05-01" version="1">MREGHQGTGPGAITPDGCAVELYSRLPVGVEPDIVAAAVPEGARILELGSGVGRMTHPLLERGFGVTAVDESAEMLERVRGARTICSPIEDLDLGERFDAVMLASFLVHAGDVEVRRGLLRTCARHVAEDGCVLIQREGADYHTNLPRERVDPSGFTIRILSADPVGDGVNSVRAQYEFPDAVWTQTFRARPLTREQFEEALGEAGLAVDRYLTDDGTWVRAVPVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2N9</accession>
    <name>Q9S2N9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2197</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35313">
        <property type="entry name" value="T35313"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626449.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976618.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2197"/>
    <dbReference type="GeneID" id="1097630"/>
    <dbReference type="KEGG" id="sco:SCO2197"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2234"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110186_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2N9"/>
    <dbReference type="OMA" id="PALIWDR"/>
    <dbReference type="PhylomeDB" id="Q9S2N9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB90844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16586" checksum="28E1966769CA502F" modified="2000-05-01" version="1">MDNRQAIGSWLSGPRAAVEEAGADFGHRGEQLGLPEEGPGSIARPGRRLGALAVDWALCSLIAYGLITGSYGQTASNWALLIFFVLSVLTVGTVGFTPGKRLFGLRVVDLATGRPSPLRALLRSVLLCLALPALIWDRDGRGLHDRLARTVEVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S6T8</accession>
    <name>Q9S6T8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative Clp-family ATP-binding protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3373</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36384">
        <property type="entry name" value="T36384"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627581.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975461.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3373"/>
    <dbReference type="GeneID" id="1098810"/>
    <dbReference type="KEGG" id="sco:SCO3373"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3436"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_11"/>
    <dbReference type="InParanoid" id="Q9S6T8"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="PhylomeDB" id="Q9S6T8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB40873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="841" mass="93014" checksum="101BE09AAADE7FFD" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX18</accession>
    <name>Q9WX18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3316</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36264">
        <property type="entry name" value="T36264"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627526.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028906.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3316"/>
    <dbReference type="GeneID" id="1098750"/>
    <dbReference type="KEGG" id="sco:SCO3316"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3376"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="InParanoid" id="Q9WX18"/>
    <dbReference type="OMA" id="ANPACEW"/>
    <dbReference type="PhylomeDB" id="Q9WX18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB45350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="26270" checksum="1F0ADFD0CED81709" modified="1999-11-01" version="1">MTGLGRLDGKRTLVIGGGGAGIGRSIVRSCAAAGAAVAVADVDAARATEAADELRAAGHVAHALSGDVRSREQLEDVIVGAADRLGGLDVLITVVGGQVAFVPAVRLHEMADADWDTVYELNLRYVARAVRRVLRLFLEQGTGGNIVGIGSVTGFMAAPMQAGYGAAKAGLHSLARTVAAEYAADGIRMNVVAGGAISTAVNAGPSDAWVPEIPAGRYGTSEEMAAAAVYLASDESRYVTGQQIVLDGGVSVRGPFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X852</accession>
    <name>Q9X852_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3391</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36079">
        <property type="entry name" value="T36079"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627598.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028950.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3391"/>
    <dbReference type="GeneID" id="1098828"/>
    <dbReference type="KEGG" id="sco:SCO3391"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3454"/>
    <dbReference type="eggNOG" id="COG1565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046703_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X852"/>
    <dbReference type="OMA" id="CDVTAHV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="362" mass="38111" checksum="0FA9407DFF95F5DF" modified="1999-11-01" version="1">MTPGTAGFRGAPEAHGTWRGWREATQEALYGPEGFYRAGPEGPAGHFRTSVHASPLFAGAVARLLCRVDEALGRPAVLDFVDMAAGRGELVAGVLAALPADVVARTRAYAVEVAARPEGLDRRVQWLARPPDGVTGLLFANEWLDNVPVDVAEVDAEGVARRVLVRGDGAERLGEPVAGAEAEWLARWWPMPAEEGRRAEIGLPRDEAWASAVAALDAGLAVAADYAHSVSARPPFGTLTGFREGRETEPVPDGSCDITAHVALDACAAAHTARCTPEYAPPNALTRPQREILRALGVTGARPPLALASTDPAAYVRALASASQGAELTARGGLGDFRWLLQPVGPVDAEALLVDVADHEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8S0</accession>
    <name>Q9X8S0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3653</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36543">
        <property type="entry name" value="T36543"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627847.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029146.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3653"/>
    <dbReference type="GeneID" id="1099089"/>
    <dbReference type="KEGG" id="sco:SCO3653"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3713"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9X8S0"/>
    <dbReference type="OMA" id="THLNRTM"/>
    <dbReference type="PhylomeDB" id="Q9X8S0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB42040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="25805" checksum="5905559D9BBF566C" modified="1999-11-01" version="1">MTDADRPTDGPHHDAAGPIRLLVVDDQYLVRTGLATLLRAAPGMEVVGEASDGAEAVVLAARTRPDVVLMDIRMPGLTGIQATERILAQAVDPAPRILVLTTFDLDEYVYGALRAGASGFLLKDAGPERLLAAVTAVHGGDALFAPAVTRRLVEAFTRMTDTGRADPPDAGPPPPALTTLTGREAEVLQLVGRGLSNAEAADRLFISEATVKTHLNRTMTKLGLTSRAQAVVVAYETGLVTPGGAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W5</accession>
    <name>Q9X8W5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3683</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36618">
        <property type="entry name" value="T36618"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627875.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029163.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099119"/>
    <dbReference type="KEGG" id="sco:SCO3683"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3741"/>
    <dbReference type="eggNOG" id="ENOG5032ACU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180111_1_0_11"/>
    <dbReference type="OMA" id="HRYSRRI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="91" mass="9765" checksum="FEBBC44F26E5BFE7" modified="1999-11-01" version="1">MDILVTVIVLLAVIASGAFLIHRLNSQHGDRGAAFHYGRGGVVAPDRKTDDGSAVRRRPSAANDADERRGRGGGGRGRLRPRRRTHGVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8X7</accession>
    <name>Q9X8X7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3695</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36630">
        <property type="entry name" value="T36630"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627887.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029170.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3695"/>
    <dbReference type="DNASU" id="1099131"/>
    <dbReference type="GeneID" id="1099131"/>
    <dbReference type="KEGG" id="sco:SCO3695"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3754"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1879773_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9X8X7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="17220" checksum="8ABD5D327C135792" modified="1999-11-01" version="1">MEKQNLPVVVVGAGPVGLAAAAHLVERGIEPLVLEAGASAATAVRDWAHVRLFSPWAEVTDPAAEKLLAPTGWLRPDGATYPTGGDWAERYLQPLADVLGDQVRYGATVTGVARAGRDRIVDSGREEQPFTVHIETADGGEERIAARAVIDAGRRGVRHADR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X909</accession>
    <name>TOP1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA topoisomerase 1</fullName>
            <ecNumber evidence="1">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA topoisomerase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">topA</name>
        <name type="ordered locus">SCO3543</name>
        <name type="ORF">SCH5.06c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB38480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36664">
        <property type="entry name" value="T36664"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627741.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029075.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X909"/>
    <dbReference type="SMR" id="Q9X909"/>
    <dbReference type="STRING" id="100226.SCO3543"/>
    <dbReference type="PRIDE" id="Q9X909"/>
    <dbReference type="GeneID" id="1098979"/>
    <dbReference type="KEGG" id="sco:SCO3543"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3599"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X909"/>
    <dbReference type="OMA" id="YAQPKQR"/>
    <dbReference type="PhylomeDB" id="Q9X909"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <feature type="chain" id="PRO_0000145166" description="DNA topoisomerase 1">
        <location>
            <begin position="1"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="1">
        <location>
            <begin position="184"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="952" mass="103585" checksum="1C98DABD7A629295" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X920</accession>
    <name>Q9X920_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3555</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36676">
        <property type="entry name" value="T36676"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627753.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3555"/>
    <dbReference type="GeneID" id="1098991"/>
    <dbReference type="KEGG" id="sco:SCO3555"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3611"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065779_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X920"/>
    <dbReference type="OMA" id="WWAARIV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="9">
        <location>
            <begin position="152"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB38492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="32190" checksum="E5EC8737A78B58D3" modified="1999-11-01" version="1">MTVAGTPVTGMPGTGELSTGVVLVCLGAAAWLAGGWHSGVRRARTVLAEGRTLAPGGPSGTDGSGGSDRPGGACAARLPTARRTTEELRRLRGRLRPEWWSLAAGLVLAILGTSVLPAVAGAAGVPVLRRVRLAGRERRAKERRQDAVIALCGTLAGEVRAGRQPGEALLCAAQDSAGLGEAQAAVLAAARFGGDVPGALALAAGQPGAEGLRGLAACWRVAVDQGAGLAAGLDRLEGALRAERDQRSDLRAQLAGARATAVMLAGLPVLGLLLGVALGSDPLHVLLHTGAGVGCLLAGGALESLGVWWVTRIVRGAEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Z4</accession>
    <name>Q9X9Z4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1798</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB45290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36859">
        <property type="entry name" value="T36859"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626068.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977024.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1798"/>
    <dbReference type="GeneID" id="1097232"/>
    <dbReference type="KEGG" id="sco:SCO1798"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1819"/>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="InParanoid" id="Q9X9Z4"/>
    <dbReference type="OMA" id="HVLMIRQ"/>
    <dbReference type="PhylomeDB" id="Q9X9Z4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="29061" checksum="3119A554DC8BB0A0" modified="1999-11-01" version="1">MSDVLELQDVTVVREGRALVDQVSWSVKEGERWVILGPNGAGKTTLLNVASSYLYPSSGTATILGETLGRPGTDVFELRPRIGVAGIAMADKLPKRQTVLQTVLTAAYGMTAGWQEEYEDIDEQRARAFLDRLGMTEYLDRRFGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVRRLGRLARDPIAPSMIMVTHHVEEIAPGFTHVLMIRQGQVLAAGPLELELTSRNLSLCFGLPLIVEQAGDRWTAKGLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAD9</accession>
    <name>Q9XAD9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35639">
        <property type="entry name" value="T35639"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629434.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030156.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5290"/>
    <dbReference type="GeneID" id="1100731"/>
    <dbReference type="KEGG" id="sco:SCO5290"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5376"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAD9"/>
    <dbReference type="OMA" id="MSVVAYH"/>
    <dbReference type="PhylomeDB" id="Q9XAD9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="150" mass="15515" checksum="D055E6CE1C65A28D" modified="1999-11-01" version="1">MPGIRSVAVVSSDGLLLLSSDPGRNEEARQARETPRAGPRGSAADLATVVSGVGSLTVGAARLMDFGPVKHTMVAMDEGSLFVMSISDGSLLGVHGSAECDMSVVAYHMALFVGRAGHVLTPELRTELRKSLESESSESSVSSEPTGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAG4</accession>
    <name>Q9XAG4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Asn-C family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5323</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35606">
        <property type="entry name" value="T35606"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629465.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973649.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5323"/>
    <dbReference type="GeneID" id="1100763"/>
    <dbReference type="KEGG" id="sco:SCO5323"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5409"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="InParanoid" id="Q9XAG4"/>
    <dbReference type="OMA" id="DDMNDQI"/>
    <dbReference type="PhylomeDB" id="Q9XAG4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17803" checksum="D306119BACDBEE33" modified="1999-11-01" version="1">MARQGLDQLDGRMLRLLRERPREGLLEIARRLGVARGTLQARLDRLTGSGVVTGYGPDMDVAALGHVVQAFTTFEVDQPAREAIAARLRAVPQILEAHVVTGPGDIWCRIAGTSNQHVQEVIDQVLEVPGVRRSTTVIALSAVVPYRVQPLVDEVSGLSEPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5A2</accession>
    <name>Q9Z5A2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6200</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34854">
        <property type="entry name" value="T34854"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630303.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030736.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6200"/>
    <dbReference type="GeneID" id="1101641"/>
    <dbReference type="KEGG" id="sco:SCO6200"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6313"/>
    <dbReference type="eggNOG" id="ENOG5033UMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100599_0_0_11"/>
    <dbReference type="OMA" id="LGCPCGT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB36608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="24078" checksum="B7D79D2CC715FFED" modified="1999-05-01" version="1">MGVMSETISVCCTACGRRHRYTAPSYPCVCGAPVAPELDPRGAATAVTHRAWDEEWIGVRCAACGAESRWPRPELGCPCGTVLCVPVDPAAAGRSGRTPGSRVPAHRAVPIRTARDAVTAAVLYLRGLGHRDVRRADQRPLSGIGLAAPGLVVQVDPTVGPASVRDVECLWLTAMAESARGVYFSLAGYAEDARVRGDLLDVALFVLDPSGVPRPANAPAVALDATAGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5A4</accession>
    <name>Q9Z5A4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6198</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34852">
        <property type="entry name" value="T34852"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030734.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6198"/>
    <dbReference type="GeneID" id="1101639"/>
    <dbReference type="KEGG" id="sco:SCO6198"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6311"/>
    <dbReference type="HOGENOM" id="CLU_008412_0_0_11"/>
    <dbReference type="OMA" id="GENENFA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005506">
        <property type="entry name" value="DUF312"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03752">
        <property type="entry name" value="ALF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177072" evidence="3">
        <location>
            <begin position="35"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="527"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB36606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1156" mass="116719" checksum="7046B814FB9517F8" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBV9</accession>
    <name>Q9ZBV9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative respiratory chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6559</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35001">
        <property type="entry name" value="T35001"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630640.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972421.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6559"/>
    <dbReference type="GeneID" id="1101998"/>
    <dbReference type="KEGG" id="sco:SCO6559"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6663"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBV9"/>
    <dbReference type="OMA" id="NHVCAVC"/>
    <dbReference type="PhylomeDB" id="Q9ZBV9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="9">
        <location>
            <begin position="230"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA22363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="286" mass="31225" checksum="2AEA5FCFF673A29F" modified="1999-05-01" version="1">MTAIPLGVPRRLVEFTLDGQEARVPEGSTILDACRAAGKDVPTLCEGDTLAPKNACRVCVVDVEGARTLAPACSRKAEPGMVVRTDTERARHSRKVVLELLASSVDLSTTPSVAQWIKEYEAKPDRFGPDAARVDEEPRVDNDLYVRDYGKCILCYKCVDACGDQWQNSFAISVAGRGFDARISVEQDGPLTDSACVYCGNCIEVCPTGALSFKSEFDMRAAGTWDQERQTETTTVCAYCGVGCNLTLHVQDNEIVKVTSPHDNPVTHGNLCIKGRFGYQHVQNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O54100</accession>
    <name>O54100_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5904</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34576">
        <property type="entry name" value="T34576"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630022.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030523.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5904"/>
    <dbReference type="GeneID" id="1101346"/>
    <dbReference type="KEGG" id="sco:SCO5904"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6002"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980340_0_0_11"/>
    <dbReference type="InParanoid" id="O54100"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13648" checksum="2BE56916AE974A64" modified="1998-06-01" version="1">MHIIAIAVRAPAGRDSHRHHTNNREKTEMSTAVTEFTVAAPAQGAFENNCTASMRATLSNVPGLRNARLLRPRKGAHGYLAVLNFEDDAAFTAYTSSEAFRAAHADPTHSLSDDNRVTVFEAVTQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O68814</accession>
    <accession>Q9S2U6</accession>
    <name>TRPC1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Indole-3-glycerol phosphate synthase 1</fullName>
            <shortName>IGPS 1</shortName>
            <ecNumber>4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trpC1</name>
        <name type="synonym">trpC</name>
        <name type="ordered locus">SCO2039</name>
        <name type="ORF">SC4G6.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="32" first="869" last="880">
            <title>The expression of the trpD, trpC and trpBA genes of Streptomyces coelicolor A3(2) is regulated by growth rate and growth phase but not by feedback repression.</title>
            <authorList>
                <person name="Hu D.S.-J."/>
                <person name="Hood D.W."/>
                <person name="Heidstra R."/>
                <person name="Hodgson D.A."/>
            </authorList>
            <dbReference type="PubMed" id="10361288"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01407.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48"/>
    <dbReference type="EMBL" id="AF054585">
        <property type="protein sequence ID" value="AAC63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35068">
        <property type="entry name" value="T35068"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626299.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028110.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O68814"/>
    <dbReference type="SMR" id="O68814"/>
    <dbReference type="STRING" id="100226.SCO2039"/>
    <dbReference type="GeneID" id="1097473"/>
    <dbReference type="KEGG" id="sco:SCO2039"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2070"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_0_0_11"/>
    <dbReference type="InParanoid" id="O68814"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="PhylomeDB" id="O68814"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154259" description="Indole-3-glycerol phosphate synthase 1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC63500." evidence="1" ref="1">
        <original>E</original>
        <variation>V</variation>
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="269" mass="28387" checksum="18688CF881D63967" modified="2000-12-01" version="3">MSVLDEIIDGVRADLAERQARVSLDELKERAAKARPAKDGVAALRGDGVKVICEVKRSSPSKGALAAIADPAGLAADYEAGGAAVISVLTEERRFGGSLADLDSVRARVDIPVLRKDFIVTSYQLWEARAHGADLVLLIVAALEQPALESLIERAESIGLTPLVEVHDEDEVERAVDAGAKVIGVNARNLKTLEVDRGTFERVAPEIPAHIVKVAESGVRGPHDLIAYANEGADAVLVGESLVTGRDPKTAVSDLVAAGEHPALRHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O69854</accession>
    <name>O69854_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6024</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34704">
        <property type="entry name" value="T34704"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630135.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972899.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6024"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1101465"/>
    <dbReference type="KEGG" id="sco:SCO6024"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6124"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015079_0_0_11"/>
    <dbReference type="InParanoid" id="O69854"/>
    <dbReference type="OMA" id="HRIYGTH"/>
    <dbReference type="PhylomeDB" id="O69854"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="697" mass="76264" checksum="2A2623D958C2DA78" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O69891</accession>
    <name>O69891_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5603</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34788">
        <property type="entry name" value="T34788"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629737.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030329.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5603"/>
    <dbReference type="GeneID" id="1101044"/>
    <dbReference type="KEGG" id="sco:SCO5603"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5695"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_11"/>
    <dbReference type="InParanoid" id="O69891"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="PhylomeDB" id="O69891"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="235"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="541" mass="56627" checksum="B7728321F749CF5A" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O69897</accession>
    <name>O69897_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5609</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34794">
        <property type="entry name" value="T34794"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030335.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101050"/>
    <dbReference type="KEGG" id="sco:SCO5609"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5701"/>
    <dbReference type="eggNOG" id="ENOG5031U8S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206014_0_0_11"/>
    <dbReference type="OMA" id="ISHKPPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="65" mass="6370" checksum="4D9BFEBFD39C0CF9" modified="1998-08-01" version="1">MNLPLGVKVLIVVICTLISVIVAMVAGFLSHASGSSVGQAILYGGGAFAGSLLLCLAVLSALGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O69900</accession>
    <name>O69900_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5612</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34797">
        <property type="entry name" value="T34797"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629746.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030338.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5612"/>
    <dbReference type="GeneID" id="1101053"/>
    <dbReference type="KEGG" id="sco:SCO5612"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5703"/>
    <dbReference type="eggNOG" id="COG3378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018483_1_2_11"/>
    <dbReference type="InParanoid" id="O69900"/>
    <dbReference type="PhylomeDB" id="O69900"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014820">
        <property type="entry name" value="PriCT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08708">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00942">
        <property type="entry name" value="PriCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="468"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA19404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="756" mass="83991" checksum="B9CEED4648B45D05" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O69963</accession>
    <name>MIAB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="1">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaB</name>
        <name type="ordered locus">SCO5787</name>
        <name type="ORF">SC4H2.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35107">
        <property type="entry name" value="T35107"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629911.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030453.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O69963"/>
    <dbReference type="SMR" id="O69963"/>
    <dbReference type="STRING" id="100226.SCO5787"/>
    <dbReference type="GeneID" id="1101229"/>
    <dbReference type="KEGG" id="sco:SCO5787"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5877"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_2_11"/>
    <dbReference type="InParanoid" id="O69963"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="PhylomeDB" id="O69963"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:N6-isopentenyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035600">
        <property type="term" value="P:tRNA methylthiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000374585" description="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="155"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="388"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="505" mass="55268" checksum="9EA1CE7DE3C5284B" modified="1998-08-01" version="1">MSSIDRSQSAGGTRTYEVRTYGCQMNVHDSERLSGLLEDAGYVRAPEGADGDADVVVFNTCAVRENADNKLYGNLGHLAPKKASRPGMQIAVGGCLAQKDRDTIVKRAPWVDVVFGTHNIGKLPVLLERARVQEEAQVEIAESLEAFPSTLPTRRESAYAAWVSISVGCNNTCTFCIVPALRGKEKDRRPGDILAEVEALVAEGVSEITLLGQNVNAYGSDIGDREAFSKLLRACGNIDGLERVRFTSPHPRDFTDDVIAAMAETPNAMPQLHMPLQSGSDPVLKAMRRSYRQERYLGIIEKVRAAIPHAAITTDIIVGFPGETEEDFEQTLHVVREARFAQAFTFQYSKRPGTPAAEMENQIPKAVVQERYERLVALQEEISWDENKKQVGRTLELMVAEGEGRKDGATHRLSGRAPDNRLVHFTKPDQEVRPGDVVTVEITYAAPHHLLAEGAVLDVRRTRAGDAWEKRNTAEQAKPAGVLLGLPKIGVPEPQPVVASGCGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O69993</accession>
    <name>O69993_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T35190"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030474.1">
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    </dbReference>
    <dbReference type="STRING" id="100226.SCO5816"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
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    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="534" mass="56854" checksum="416D7E8D2E038EF2" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O70004</accession>
    <name>O70004_STRCO</name>
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        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ordered locus">SCO5828</name>
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    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T35202"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629951.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030483.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5828"/>
    <dbReference type="GeneID" id="1101270"/>
    <dbReference type="KEGG" id="sco:SCO5828"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5925"/>
    <dbReference type="eggNOG" id="COG4565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_39_1_11"/>
    <dbReference type="InParanoid" id="O70004"/>
    <dbReference type="OMA" id="MRHGALQ"/>
    <dbReference type="PhylomeDB" id="O70004"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="24940" checksum="6A93280D3145723A" modified="1998-08-01" version="1">MIEVLVVDDDTRVARVNAAYVEKVPGFHVAAEAHSALEALDAVERLPRLDLILLDHYLPDRTGLEVVQEMRRRGRQTDVIMVTAARDVSTVQATMRQGALQYLVKPFAFAGLRAKLEAYAELRRTLDGGGEAEQAEVDRIFGALSAPSEPGLPKGHSPTTAELVRQCLLKADGPLSAQEIAERTGVSRQTAQRYLKLLERTGRAVLTLKYGEAGRPEHRYAWVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O86641</accession>
    <name>O86641_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO5721</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629847.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030413.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5721"/>
    <dbReference type="GeneID" id="1101160"/>
    <dbReference type="KEGG" id="sco:SCO5721"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5812"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036302_1_1_11"/>
    <dbReference type="InParanoid" id="O86641"/>
    <dbReference type="OMA" id="FGAWGMF"/>
    <dbReference type="PhylomeDB" id="O86641"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAA20256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="508" mass="53915" checksum="DA5E117186B60965" modified="1998-11-01" version="1">MASRRDELNAYTFAKRRLLAAFLQPSPSGTEEGAPKPLRTVVPSLVAGALTLAVFGAWGMFQPTAPSGWDEPGARVIVGKQSTTRYVVLKTDGDTRLHPVLNLASARLLMKDGTYEVVQVGDDVLDSGEIPRGPILGIPYAPDRLPAPEEAGRAKRWAVCEQPGGKGETVQEATFVLASQEAAKTEGAGRLKGGDTLYVATRTGERYLVDAEGSSYHVTGTESDALTTALVGSRKPQLVTNEWLATLHQGDPIRFPPLPPAVGTPAGVSGALSAQENKVGTVLKTETGEGTKYYVVLPGKVQPITEFTAWLLITSPQTATLNMNGEARTVGLQDFTAEPDPFEGQPDDWPRQRVHQVNSASAGTGRDTVCSVLRKVDTEGDTTLSTWAGQQYPAEITSDGTSTHVTPGTGLLYTQIQGTGTDSGSLFLVTDTGLRYAVQANGDSDADRSDIGADGRKKTSDGSPEPSEAQVKLGYENVRPAKVPLAWSEFLAKGPRLDTNSARQPQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O86743</accession>
    <name>O86743_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5656</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35442">
        <property type="entry name" value="T35442"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629786.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030367.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5656"/>
    <dbReference type="GeneID" id="1101095"/>
    <dbReference type="KEGG" id="sco:SCO5656"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5740"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_2_11"/>
    <dbReference type="OMA" id="TYMWGTR"/>
    <dbReference type="PhylomeDB" id="O86743"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA19896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="18295" checksum="BC5E19B6FF6EBABE" modified="1998-11-01" version="1">MASRSADQKDSRESRNGGPQLDAVSLAIIEQLQEDGRRPYAAIGKAVGLSEAAVRQRVQKLLDQGVMQIVAVTDPLTVGFRRQAMVGVNVEGDVESVAEALSAMSECEYVVMTAGSFDLMVEVVCEDDDHLLEVINRRIRAVPGVRSTESFVYMKLKKQTYMWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O86757</accession>
    <name>O86757_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35456">
        <property type="entry name" value="T35456"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629772.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030357.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5642"/>
    <dbReference type="GeneID" id="1101081"/>
    <dbReference type="KEGG" id="sco:SCO5642"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093776_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="28153" checksum="B1D61EC233FFF4CA" modified="1998-11-01" version="1">MEVLVNSRLAQENRLFISYAHADNDLFGDAVKSFAADLKGFYAVKTGDALSVFFDRESIGWGDNWRIEIDGELENASIFMPVITMQYFNRPACRDELNAFNQSARRLGAQYLILPVVIAGAAAIRADHPIPEVATIAELQYRNLEDAFLAGKGTSEWRRALSTLADELITLISRAEHAAPTLAPRDVANTGDMGLSPNDDSDFLSSIAELDVLSRDVGDTRAGFLKWVRASRFGVDCDISTEFRRPSWSTVMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>O86794</accession>
    <name>O86794_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4753</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35582">
        <property type="entry name" value="T35582"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628911.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029842.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4753"/>
    <dbReference type="GeneID" id="1100194"/>
    <dbReference type="KEGG" id="sco:SCO4753"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4825"/>
    <dbReference type="eggNOG" id="ENOG50348QT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189245_0_0_11"/>
    <dbReference type="OMA" id="LMWEARA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="90" mass="10460" checksum="A1513AC604CD262D" modified="1998-11-01" version="1">MTVALMWEARAVPGRGGELLAWARRQELPRRPLRRETLRAPQDRVLVITWWDAGYDAALPELPEPDGNLVTRAVHRWRFESVEDDDLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O88009</accession>
    <name>O88009_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6653</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35152">
        <property type="entry name" value="T35152"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630728.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031079.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6653"/>
    <dbReference type="GeneID" id="1102092"/>
    <dbReference type="KEGG" id="sco:SCO6653"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_4_0_11"/>
    <dbReference type="OMA" id="WGVREAS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA19932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="400" mass="40726" checksum="ED99F85421C3A020" modified="1998-11-01" version="1">MSAPTLPTVSTVPAAVPPTPVRPHAPTGVAAPRRRALRAHLGTLAGTAVLAVLLWRLGTGAFLDGLRRIDGPAVLAALGIGLVTTVFSAWRWALVARGLRIRLPLAAAVADYYRALFLNAALPGGVLGDVHRAVRHGRSTGDLGRGVRAVVLERVAGQLALIGAGAGVLLTMPSPVRAEVRHLAPLVALALAGALAVVLALRWNRAPARRGRAVRTALGEARHGLLSRRNLPGIVLSSAIVLAGHLTMFVVAARVAGSAASVAVLTPLAVLALLAMGLPLNVGGWGPREGVTAWAFGAAGLGAGTGLGVAVVYGVLSLVASLPGVVVLVGRRYAARYPRSPSEPSEASESSEPSDVDGVPAVSAVSSATYSPKESARLSSSSFPFSADPSEGRPMTPESV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O88058</accession>
    <name>RL20_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplT</name>
        <name type="ordered locus">SCO1598</name>
        <name type="ORF">SCI35.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36833">
        <property type="entry name" value="T36833"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977226.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O88058"/>
    <dbReference type="SMR" id="O88058"/>
    <dbReference type="STRING" id="100226.SCO1598"/>
    <dbReference type="GeneID" id="1097029"/>
    <dbReference type="KEGG" id="sco:SCO1598"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1610"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_0_11"/>
    <dbReference type="InParanoid" id="O88058"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="PhylomeDB" id="O88058"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000177236" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="127" mass="14387" checksum="80D1308A1266F593" modified="1998-11-01" version="1">MARVKRAVNAHKKRRAILEQASGYRGQRSRLYRKAKEQVTHSLVYNYNDRKKRKGDFRQLWIQRINAAARANGITYNRFIQGLKAANVEVDRKILAELAVNDPNAFAALVEVAQKALPSDVNAPKAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>P16245</accession>
    <accession>Q59834</accession>
    <accession>Q9S2T5</accession>
    <name>HISX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Histidinol dehydrogenase</fullName>
            <shortName>HDH</shortName>
            <ecNumber>1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hisD</name>
        <name type="ordered locus">SCO2054</name>
        <name type="ORF">SC4G6.23c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Res. Microbiol." volume="143" first="683" last="693">
            <title>Further characterization of the histidine gene cluster of Streptomyces coelicolor A3(2): nucleotide sequence and transcriptional analysis of hisD.</title>
            <authorList>
                <person name="Limauro D."/>
                <person name="Avitabile A."/>
                <person name="Puglia A.M."/>
                <person name="Bruni C.B."/>
            </authorList>
            <dbReference type="PubMed" id="1488552"/>
            <dbReference type="DOI" id="10.1016/0923-2508(92)90063-T"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-288</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="Gene" volume="90" first="31" last="41">
            <title>Cloning and characterization of the histidine biosynthetic gene cluster of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Limauro D."/>
                <person name="Avitabile A."/>
                <person name="Cappellano M."/>
                <person name="Puglia A.M."/>
                <person name="Bruni C.B."/>
            </authorList>
            <dbReference type="PubMed" id="2199329"/>
            <dbReference type="DOI" id="10.1016/0378-1119(90)90436-U"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 287-441</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X64420">
        <property type="protein sequence ID" value="CAA45767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M31628">
        <property type="protein sequence ID" value="AAA26755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35083">
        <property type="entry name" value="T35083"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626314.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028117.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P16245"/>
    <dbReference type="SMR" id="P16245"/>
    <dbReference type="STRING" id="100226.SCO2054"/>
    <dbReference type="GeneID" id="1097488"/>
    <dbReference type="KEGG" id="sco:SCO2054"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2086"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_1_11"/>
    <dbReference type="InParanoid" id="P16245"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="PhylomeDB" id="P16245"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000135860" description="Histidinol dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; CAA45767." evidence="2" ref="2">
        <original>Q</original>
        <variation>L</variation>
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="441" mass="46493" checksum="3B0B26BA17F91743" modified="2000-12-01" version="3">MISRIDLRGDALPEGPALRDLLPRADFDVSVALEKVRPICEAVHHRGDAALIDFTEQFDGVRLERVRVPAEELTRALEGLDPEVRAALEESIRRARLVHREQRRATHTTQVVPGGSVTEKWVPVERVGLYVPGGRSVYPSSVVMNVVPAQEAGVGSIALASPAQAEFGGIPHPTILAACALLGVDEVYAAGGATAVAMFAYGTESCPPANMVTGPGNIWVAAAKRFFTGKIGIDAEAGPTEIAVLADSTADPVHVASDLISQAEHDPLAAAVLVTDSAELADAVEKELQPQVEATKHIEDRIRPALAGRQSAIVLVDGLDEGLRVVDAYGAEHLEIQTADAAAVADRVKNAGAIFVGPWAPVSLGDYAAGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTRDALAEVARHVVTLAEAEDLPAHGAAIKARFEWKVPESK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P45500</accession>
    <name>FTSZ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsZ</name>
        <name type="ordered locus">SCO2082</name>
        <name type="ORF">SC4A10.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Mol. Microbiol." volume="14" first="243" last="254">
            <title>Growth and viability of Streptomyces coelicolor mutant for the cell division gene ftsZ.</title>
            <authorList>
                <person name="McCormick J.R."/>
                <person name="Su E.P."/>
                <person name="Driks A."/>
                <person name="Losick R."/>
            </authorList>
            <dbReference type="PubMed" id="7830569"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1994.tb01285.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="U10879">
        <property type="protein sequence ID" value="AAD10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S60765">
        <property type="entry name" value="S60765"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626341.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976733.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P45500"/>
    <dbReference type="SMR" id="P45500"/>
    <dbReference type="STRING" id="100226.SCO2082"/>
    <dbReference type="PRIDE" id="P45500"/>
    <dbReference type="GeneID" id="1097516"/>
    <dbReference type="KEGG" id="sco:SCO2082"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2115"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_2_0_11"/>
    <dbReference type="InParanoid" id="P45500"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="PhylomeDB" id="P45500"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000114388" description="Cell division protein FtsZ">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="399" mass="41095" checksum="EAD52B04CFBB4D39" modified="1995-11-01" version="1">MAAPQNYLAVIKVIGVGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPAVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAELREEVDTLIVIPNDRLLSISDRQVSVLDAFKSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSEAGSALMGIGSARGDDRAVAAAEMAISSPLLEASIDGARGVLLSISGGSDLGLFEINEAAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPSKRDNVLGSSSAKREEPTPARPSESRPSFGSLGSVKPKEEPEPAPVPEPVADLPVSPPPVPPSRTYSDSAAEELDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKF6</accession>
    <name>Q7AKF6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator, BldB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5723</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42023">
        <property type="entry name" value="T42023"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629849.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030415.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5723"/>
    <dbReference type="GeneID" id="1101162"/>
    <dbReference type="KEGG" id="sco:SCO5723"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5814"/>
    <dbReference type="eggNOG" id="ENOG502ZTSC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_1_1_11"/>
    <dbReference type="OMA" id="PGTEEHE"/>
    <dbReference type="PhylomeDB" id="Q7AKF6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="10901" checksum="D9B9CD45C6A3DF11" modified="2012-05-16" version="1">MAQVPDEDVKARKERERDELYALDISGVEWHSAPGTEEHEERVEIAYLPDGAVAMRSSLDPETVLRYTEAEWRAFVLGARDGEFDLEPAPGDGGVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKR2</accession>
    <name>Q7AKR2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978080.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0780"/>
    <dbReference type="GeneID" id="1096203"/>
    <dbReference type="KEGG" id="sco:SCO0780"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.772"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="InParanoid" id="Q7AKR2"/>
    <dbReference type="OMA" id="TSWQALK"/>
    <dbReference type="PhylomeDB" id="Q7AKR2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="33213" checksum="44B2871228BB4A84" modified="2004-07-05" version="1">MNTMRAIGQDVLGGPEVLKEVRPERPEPRPNEVLVRVRAAGVNPTDWKHRATGGFLGEPPFVLGWDVSGVVESVGIGVAAFRPGDEVFGMLSYPFGHGSHAEYVTAPARTFTRKPSGIDHVQAGALPLVSLTAWQALVERAEVQPGQRVLVHAAAGGVGHVAVQIAKARGARVIGTASAAKHEFLRSLGADETVDYRETDFAEAVKDVDVVLDTIGGDTSLRSLRVLRPGGVVVSILPVGSDDFYEEADRLGVRAVRMLVDADRAGMEEIARLVGAGRLRATIAQTFPLAEAARAHALGETGRTTGKLVLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK00</accession>
    <name>Q8CK00_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50564">
        <property type="entry name" value="T50564"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733566.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028229.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2255"/>
    <dbReference type="GeneID" id="1097688"/>
    <dbReference type="KEGG" id="sco:SCO2255"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2292"/>
    <dbReference type="eggNOG" id="COG3021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058628_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK00"/>
    <dbReference type="OMA" id="WPASFPM"/>
    <dbReference type="PhylomeDB" id="Q8CK00"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="350" mass="37222" checksum="A7B9A74F5D10DED3" modified="2003-03-01" version="1">MAQQAYMTETDGGGSDPERRENRIRRLFDRAVSGWRGDRRIWRRGLVTAAVALLLSAVMAAHSHIPNAIGNLGSLTETFLPWFGLLIPVLLVIALVRKSATALIALVVPVSVWLNLFGGLLFDKTGSGGDLTVATHNVNADNADPAGTARAVAAAGADVMALEELKASAVPTYEKALAAKYPHHAVVGTVGLWSKYPISGVKPVDIELGWKRAMRATVTTPSGPIAVYVAHLPSVRVKLEAGFTARQRDKSADALGEAISHERLPRKILLGDLNGTMNDRSLTAITSQLRSPQGAVGDGFGFSWPASFPMARIDQILVTGVEPMTSWTLPATGSDHLPIAARVKVDTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK35</accession>
    <name>Q8CK35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1226</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAD55167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733527.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027657.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1226"/>
    <dbReference type="CAZy" id="CBM12">
        <property type="family name" value="Carbohydrate-Binding Module Family 12"/>
    </dbReference>
    <dbReference type="MEROPS" id="M28.003"/>
    <dbReference type="GeneID" id="1096649"/>
    <dbReference type="KEGG" id="sco:SCO1226"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1225"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_289316_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK35"/>
    <dbReference type="OMA" id="TSGMTYK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176138" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1066" mass="110384" checksum="25312E0554BB70D8" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK37</accession>
    <name>Q8CK37_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1167</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAD55164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733524.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027624.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1167"/>
    <dbReference type="GeneID" id="1096590"/>
    <dbReference type="KEGG" id="sco:SCO1167"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1165"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_8_11"/>
    <dbReference type="InParanoid" id="Q8CK37"/>
    <dbReference type="OMA" id="FGPRARM"/>
    <dbReference type="PhylomeDB" id="Q8CK37"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="436"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="721"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="890" mass="96317" checksum="7A47F61158EEC8A1" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWD9</accession>
    <name>Q8VWD9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypoth_Ymh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP2.13c</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3 4">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639769.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039587.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095056"/>
    <dbReference type="KEGG" id="sco:SCP2.13c"/>
    <dbReference type="HOGENOM" id="CLU_098644_0_0_11"/>
    <dbReference type="OMA" id="NQAFSEQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012654">
        <property type="entry name" value="CHP02391"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09509">
        <property type="entry name" value="Hypoth_Ymh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypoth_Ymh" evidence="2">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="21298" checksum="ECAC4C0A1BD68DED" modified="2002-03-01" version="1" fragment="single">RSRRRNHSPMTQINREWAITRLETFIDTAALQTTTHGYIALANPLATVQAEAQIAEQILDKVLPGWRTADWKKRSAAFWREREAAHRAIAQLRAEQELADNLGSGAPQLDASTMHPWVWGSIQGLWSSGHYRQAVGMAATAVNAQAQTKVSRRDLSEWKLFGDAFSTKPPEPGKPRLRLSVNDGSDTWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IZ0</accession>
    <name>Q93IZ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629241.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030050.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q93IZ0"/>
    <dbReference type="STRING" id="100226.SCO5091"/>
    <dbReference type="GeneID" id="1100532"/>
    <dbReference type="KEGG" id="sco:SCO5091"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5171"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_1_1_11"/>
    <dbReference type="InParanoid" id="Q93IZ0"/>
    <dbReference type="OMA" id="HMGDLFF"/>
    <dbReference type="PhylomeDB" id="Q93IZ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="31929" checksum="4749F3ECA1E325ED" modified="2001-12-01" version="1">MTVEVREVAEGVYAYEQAPGGWCVSNAGIVVGGDGALVVDTLSTIPRARRLAEWVDKLAAGPGRTVVNTHFHGDHAFGNQVFAPGTRIIAHEDMRSAMVTTGLALTGLWPRVDWGEIELRPPNVTFRDRLTLHVGERQVELICVGPAHTDHDVVVWLPEERVLFAGDVVMSGVTPFALFGSVAGTLAALDRLAELEPEVVVGGHGPVAGPEVIDANRDYLRWVQRLAADAVDRRLTPLQAARRADLGAFAGLLDAERLVANLHRAHEELLGGHVRDAMAIFAELVAYNGGQLPTCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ2</accession>
    <name>Q93JJ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO1969</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626232.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028072.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1969"/>
    <dbReference type="GeneID" id="1097403"/>
    <dbReference type="KEGG" id="sco:SCO1969"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1995"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_11"/>
    <dbReference type="InParanoid" id="Q93JJ2"/>
    <dbReference type="OMA" id="SGFNRQV"/>
    <dbReference type="PhylomeDB" id="Q93JJ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="19379" checksum="03D9513C988A5BE8" modified="2001-12-01" version="1">MDSHGQYEQQVVWTVVGTDIGPLLLAATHDGLVNVVFHATDATRGRALERLAARLGTEPVEAPGSPLLAEAIRQVEAYFAGRRRDFELPLDWSLISGFNRQVLRELASGVPYGSVVGYGDLAGRVGQPGAAQAVGMAMGANPLPVVVPCHRVVESDGGIGGFGGGVDTKRRLLALEGVLPEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RV7</accession>
    <name>Q93RV7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2009-03" db="PDB data bank">
            <title>Crystal structure of probable DsbA oxidoreductase SCO1869 from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Chang C."/>
                <person name="Xu X."/>
                <person name="Cui H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A.M."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626136.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976951.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="PDB" id="3GL5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A=1-237"/>
    </dbReference>
    <dbReference type="PDBsum" id="3GL5"/>
    <dbReference type="SMR" id="Q93RV7"/>
    <dbReference type="STRING" id="100226.SCO1869"/>
    <dbReference type="DNASU" id="1097303"/>
    <dbReference type="GeneID" id="1097303"/>
    <dbReference type="KEGG" id="sco:SCO1869"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1894"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069253_0_2_11"/>
    <dbReference type="InParanoid" id="Q93RV7"/>
    <dbReference type="OMA" id="KPTNTFD"/>
    <dbReference type="PhylomeDB" id="Q93RV7"/>
    <dbReference type="EvolutionaryTrace" id="Q93RV7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC38804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3GL5"/>
        </source>
    </evidence>
    <sequence length="237" mass="25784" checksum="CD6E5B6408C8018F" modified="2001-12-01" version="1">MRVEIWSDIACPWCYVGKARFEKALAAFPHRDGVEVVHRSFELDPGRAKDDVQPVLTMLTAKYGMSQEQAQAGEDNLGAQAAAEGLAYRTRDRDHGSTFDLHRLLHLAKERGRHEALLDAFYRGNFADERSVFNDDERLVELAVGAGLDAEEVRAVLADPAAYADEVRADEREAAQLGATGVPFFVLDRAYGVSGAQPAEVFTQALTQAWGERTPLKLIDDGGAEACGPDGCAVPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACS0</accession>
    <name>Q9ACS0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.248c</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639858.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039550.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095331"/>
    <dbReference type="KEGG" id="sco:SCP1.248c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8194"/>
    <dbReference type="HOGENOM" id="CLU_194652_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8289" checksum="386DE1A3EB5B9DDE" modified="2001-06-01" version="1">MAGIEVDDTTADELRALADAAGLPLDAYLAQVAEEKRRERALAEGAEIFRRVTGTPETVAAFDAEYGGPAQAQTAPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD70</accession>
    <name>Q9AD70_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.78</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639653.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039379.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095157"/>
    <dbReference type="KEGG" id="sco:SCP1.78"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8028"/>
    <dbReference type="HOGENOM" id="CLU_1128587_0_0_11"/>
    <dbReference type="OMA" id="ARTMIEP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="242" mass="25843" checksum="B6C2F3A93D027056" modified="2001-06-01" version="1">MGKTAKRARQAPPLSVDRVRTGWQGPVGTRIRLALGQDVEAANALMATTGDGVRIIPVLATAIEDGSASSAMLAGLGGIGTNAYHEAASHTFTDRPMNEALTTVSLTLVAADEEDRIVGVLSATAPGTLIDMAMSNGFTAEKAMALSLFVAKIHGLAVAEHARGQGIAAALLKRTWQVYQQLGYMLLYGSYEADRDLAAFYTRSGYTVHAPGETFPLDRIALPFRLGAGHDQCVFTRWRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADD4</accession>
    <name>Q9ADD4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629473.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030182.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9ADD4"/>
    <dbReference type="STRING" id="100226.SCO5333"/>
    <dbReference type="REBASE" id="187507">
        <property type="entry name" value="ScoA3IV"/>
    </dbReference>
    <dbReference type="GeneID" id="1100773"/>
    <dbReference type="KEGG" id="sco:SCO5333"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061333_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADD4"/>
    <dbReference type="OMA" id="HLAYHRR"/>
    <dbReference type="PhylomeDB" id="Q9ADD4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="PTHR14140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="32711" checksum="7725DE19CAC02FC6" modified="2001-06-01" version="1">MIGEIPGVAAGQPYNSRRLAHEAGVHRPLQAGICGTKATGAESIVVSGGYKDDEDYGDVIIYTGHGGRDSAGNQVSDQSLDDSGNAALVTSYLRGLPVRVIRGSQSGSPFAPSNGYRYDGLYRVASYTSKLGIDGFLIWQFRMEAYEETPTPKITKVRALFAEPTDCAKQDPVAASGTEQPERVTSMVQRIVRSSAIADTVKAWHQDQCQTCGIHIEVPGGFYSEGAHIQALGRPHNGPDRTDNMLCLCPNCHVMLDAGAIVLSDDLIVSKNGQLVGPLRTHPKHKVNIECVRRHRERWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADF5</accession>
    <name>Q9ADF5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6108</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630216.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030656.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6108"/>
    <dbReference type="GeneID" id="1101549"/>
    <dbReference type="KEGG" id="sco:SCO6108"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6211"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029441_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADF5"/>
    <dbReference type="OMA" id="GTYWDQG"/>
    <dbReference type="PhylomeDB" id="Q9ADF5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176610" evidence="2">
        <location>
            <begin position="48"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="47"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="520" mass="55428" checksum="5A31269A79814C9E" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN7</accession>
    <name>Q9ADN7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4020</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628202.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029387.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4020"/>
    <dbReference type="GeneID" id="1099456"/>
    <dbReference type="KEGG" id="sco:SCO4020"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4083"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="InParanoid" id="Q9ADN7"/>
    <dbReference type="OMA" id="QLWGYPP"/>
    <dbReference type="PhylomeDB" id="Q9ADN7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="46"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="30167" checksum="4CC96D870FDEE3C1" modified="2001-06-01" version="1">MPERFSEKSQVGERAFSERPDIVSAMTTTSPQGRTELLRPDGSPVRVLVVDDEQSITELLSMALRYEGWQIRSAGDGHGAVQTARDFRPDAVVLDMMLPDMDGLSVLGRLRRDLPDVPVLFLTAKDAVEDRIAGLTAGGDDYVTKPFSLEEVVARLRGLIRRSGAADRRSDSVLVVGDLTLDEDSHEVTRSGDGIHLTATEFELLRFLMRNPRRVLSKAQILDRVWSYDFGGQANVVELYISYLRRKIDAGREPMIHTRRGAGYLIKPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK93</accession>
    <name>Q9AK93_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO1369</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625653.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027751.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1369"/>
    <dbReference type="GeneID" id="1096792"/>
    <dbReference type="KEGG" id="sco:SCO1369"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1377"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_11"/>
    <dbReference type="InParanoid" id="Q9AK93"/>
    <dbReference type="OMA" id="LAWCLHL"/>
    <dbReference type="PhylomeDB" id="Q9AK93"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="196"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="42019" checksum="2DB3D106C82D07B4" modified="2001-06-01" version="1">MNVSAPAPTPTSRALAWCLHLLVVGLLVLVAARAVTDGRTPTATIVAVAVACGLVYAAGPLLPRVRLVRRVAAWWLTAVGAVWLALLALSPEAVWVAFPLYFLQLHLLSRRAGLAAVTATAVAAVAGFAAHTGSFGPAMVIGPTLGAAVAAAVVWGYQALYRESERRRRLIEALTATRADLARAQHTAGVLAERERLAREIHDTLAQGLSSIQLLLRAAERALPERPGTAAGHVVAARRAAVDSLAEARRFVAALTPPALEGTTLADALERLCATARVRHRITTRFHLAGTPVPLPTAHEVALLRVAQSALANTVRHADAGTAEITLSHLGDHVALDVVDDGTGFDPDALPPPDPEAGGFGLAAMRARLDALGGTLSIESAPGHGTALAARLPLVPPTEPEAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWM9</accession>
    <name>Q9EWM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7760</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631793.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031887.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7760"/>
    <dbReference type="GeneID" id="1103197"/>
    <dbReference type="KEGG" id="sco:SCO7760"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_47_13_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="38" mass="4062" checksum="67E9A81F55D888C2" modified="2001-03-01" version="1" fragment="single">RVPLGRSGAPGDVADMIDFLASDRAKWLTDAQFRVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWU5</accession>
    <name>Q9EWU5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625030.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978135.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0726"/>
    <dbReference type="GeneID" id="1096149"/>
    <dbReference type="KEGG" id="sco:SCO0726"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.716"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_0_1_11"/>
    <dbReference type="InParanoid" id="Q9EWU5"/>
    <dbReference type="OMA" id="DIEPGHD"/>
    <dbReference type="PhylomeDB" id="Q9EWU5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="17709" checksum="11CA7691033AC980" modified="2001-03-01" version="1">MAAMDVFLDRLDPDMCVVTAAADGERAGCLVGFSSQCSIRPVRYVVWISDVNRTFRVARSADVLAVHLLARDQRATAELFGGLTGDDVDKFGRVRWREAYGGAAVLEDAEAWFVGRVLERMPGGDHVGFVLEPVEWGGRERAAAPLLRLADARTVRPGHPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWV5</accession>
    <name>Q9EWV5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4922</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629075.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029951.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4922"/>
    <dbReference type="GeneID" id="1100363"/>
    <dbReference type="KEGG" id="sco:SCO4922"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5001"/>
    <dbReference type="eggNOG" id="ENOG50341UY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112484_0_0_11"/>
    <dbReference type="OMA" id="KIGGVVF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="16567" checksum="B801907140BC9556" modified="2001-03-01" version="1">MSVRRPVAWTVAVVLFAEAVGVAALNWFLAIVVDRQDMSLAGLDPDVMSVSSKIGGVVFGLYFALCALVALLVALRDRAPAGLGRILLISAAVVHGLLGAFTWGLVGPGAFIFMIVVLGLIVLLLMTYDAREQPAAGQRTEDGKGGDGSPVSPPPAPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX15</accession>
    <name>Q9EX15_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1111</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625404.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027580.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1111"/>
    <dbReference type="GeneID" id="1096534"/>
    <dbReference type="KEGG" id="sco:SCO1111"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1108"/>
    <dbReference type="eggNOG" id="COG3327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137120_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EX15"/>
    <dbReference type="OMA" id="YGDHLRP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="2">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="3">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="268" mass="29521" checksum="E3DED2373B19A8B0" modified="2001-03-01" version="1">MGARTVRAHVDERRGAARMTGSGDPGRLTLRPLSARSVILSLLLGTHPPELPARDLVRLVAGFDVGASTARAALSRMAAAGDLRRTDTGYRLSERLLERQRRQDEALRPHTRAWDGDWETLVITATGRDPAARAELRTRLAALRLAELREGVWLRPANLDRPLPTDLGRVAERLVSRPGSPAVELAARLWPLVDWADTARALLVHVDRARRPAGLLTAFAAVVRHLLADPVLPPELLPPDWPGTALRDAYARYQREQSGQVRAHGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2R5</accession>
    <name>Q9F2R5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO4474</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
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                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
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                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
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                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
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                <person name="Chen C.W."/>
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                <person name="Hidalgo J."/>
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                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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                <person name="Rutherford K."/>
                <person name="Rutter S."/>
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                <person name="Wietzorrek A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="18821" checksum="FD3BB07CAA04B830" modified="2001-03-01" version="1">MQAELVGEHSCGREHRARPHWKAITVTPHTSPSPGLLPPARPDLEHWFDLPSLRISVRTARDTVRRQLRTWRLPGDVCTDAVLLVSELATNAVLHSGGDRMLCGLSLTSHEQLRIEMHDDGRTSAGPAGCGSGPRDESGRGLLIVQQLADSWGTARSDRTGGTTVWAVLRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3J2</accession>
    <name>Q9F3J2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5273</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629419.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030143.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5273"/>
    <dbReference type="GeneID" id="1100714"/>
    <dbReference type="KEGG" id="sco:SCO5273"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5358"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462243_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F3J2"/>
    <dbReference type="PhylomeDB" id="Q9F3J2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="70"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC05946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="620" mass="61451" checksum="658C6B61BA2F3067" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3N2</accession>
    <name>Q9F3N2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7655</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631695.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971489.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7655"/>
    <dbReference type="GeneID" id="1103093"/>
    <dbReference type="KEGG" id="sco:SCO7655"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7775"/>
    <dbReference type="eggNOG" id="COG4989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_8_1_11"/>
    <dbReference type="InParanoid" id="Q9F3N2"/>
    <dbReference type="OMA" id="VVYAWVM"/>
    <dbReference type="PhylomeDB" id="Q9F3N2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="310" mass="34298" checksum="85999B80606FFB76" modified="2001-03-01" version="1">MKTFTLPGTDMVVPNIVLGLMRIQDMDDDEVRTLVHTARDAGITFLDHADVYGTGSHGCERRFAEALKLSPSEREQFVIQTKAGIVKDGPYFDFSHEHIVESVNGSLEALGTEYLDILLLHRPDALVEPEEVARAFDELSAAGKVRAFGVSNQTPRQLDLLRKYVRQPIVANQLQLSVTHAPMIAQGIAANMQGLDQSVVRDDGIVDYCRLHDITVQAWSPFQAGFFDGPFLGSPRYPELNAVIDRLSEKYGVPAEAIAVAWITRHPARMQVVLGTTTPERVEAAALGSDLPLTRPEWYELFRAAGYTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3N3</accession>
    <name>Q9F3N3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7654</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631694.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971490.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7654"/>
    <dbReference type="GeneID" id="1103092"/>
    <dbReference type="KEGG" id="sco:SCO7654"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7774"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="InParanoid" id="Q9F3N3"/>
    <dbReference type="OMA" id="FKVATVQ"/>
    <dbReference type="PhylomeDB" id="Q9F3N3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004033">
        <property type="term" value="F:aldo-keto reductase (NADP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="29927" checksum="30EEA8E0893F13E7" modified="2001-03-01" version="1">MQQRTIGGRSVSAIGLGGMPMSIEGRPDPERSIATIHAALDAGVTLIDTADSYHRDANEVGHNEELIARALREYGAAGADVLVATKGGHLRPGDGTWTRNGDPAYLKRAAKESARRLGVDAIGLYQFHRPDPAVPYADSVGALRELLDEGVILMAGISNAGIAQIDEAREVLGGRLVSVQNQFSPAFRSSRSELEHCAGLGIAFLPWSPLGGIANAKELAARHGVFQQVADETGTSVHQVALAWQLALAPVVIPIPGASRPASIRDSAAAADLELTRDQVALLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBS9</accession>
    <name>Q9FBS9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO7163</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2017" name="J. Microbiol." volume="55" first="388" last="395">
            <title>Crystal structure of Streptomyces coelicolor RraAS2, an unusual member of the RNase E inhibitor RraA protein family.</title>
            <authorList>
                <person name="Park N."/>
                <person name="Heo J."/>
                <person name="Song S."/>
                <person name="Jo I."/>
                <person name="Lee K."/>
                <person name="Ha N.C."/>
            </authorList>
            <dbReference type="PubMed" id="28455590"/>
            <dbReference type="DOI" id="10.1007/s12275-017-7053-8"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.09 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971979.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="PDB" id="5X15">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.09 A"/>
        <property type="chains" value="A/B/C=1-270"/>
    </dbReference>
    <dbReference type="PDBsum" id="5X15"/>
    <dbReference type="SMR" id="Q9FBS9"/>
    <dbReference type="STRING" id="100226.SCO7163"/>
    <dbReference type="GeneID" id="1102601"/>
    <dbReference type="KEGG" id="sco:SCO7163"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7264"/>
    <dbReference type="eggNOG" id="COG0684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072626_3_0_11"/>
    <dbReference type="InParanoid" id="Q9FBS9"/>
    <dbReference type="OMA" id="DIAFCDP"/>
    <dbReference type="PhylomeDB" id="Q9FBS9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAC01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5X15"/>
        </source>
    </evidence>
    <sequence length="270" mass="29518" checksum="8B9A81C900B8DCAF" modified="2001-03-01" version="1">MSLPRPAGHEADGAAAADAKPVWDLPVHGEPWERPDGELVRSLNRVSSATACAKLHELGIRRSYLSGPTALDLGNKVTGPARTLQFMPQREDVASGLAQEYVERSTALWAVLEEVQPGDVLVVQAYGSAFTGCLGDMLVRYFKRKGGAGIVVDGRIRDAPRVRELGVPIWCTGTTPHYASQSELFPWAYDVPVAAGGVLTLPGDLVVADDDGAVVVPVSKAQEIVDSAFDHEQWEEFSRMRIDQGARLSDYYPLSPDSREEYEQWRASKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC32</accession>
    <name>Q9FC32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7052</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031403.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102490"/>
    <dbReference type="KEGG" id="sco:SCO7052"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7156"/>
    <dbReference type="HOGENOM" id="CLU_1926408_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="14648" checksum="71F8E9B26BA932D6" modified="2001-03-01" version="1">MQDRAGELRVARVDHDGVPVPTGQDDPAARTEDPSRLRHRAFRFLEYVEDRLRAVASHASLGEGQFLRSRLPELALRPPLPGRRRGAPVENRGGSGLLELIEGGLDREYDDVTQCPDHRRRITGRIGPEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC55</accession>
    <name>Q9FC55_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7131</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631192.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972012.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7131"/>
    <dbReference type="ESTHER" id="strco-SC4B10.32">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="1102569"/>
    <dbReference type="KEGG" id="sco:SCO7131"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7231"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_0_11"/>
    <dbReference type="InParanoid" id="Q9FC55"/>
    <dbReference type="OMA" id="INYALAP"/>
    <dbReference type="PhylomeDB" id="Q9FC55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="79"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC04237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34103" checksum="E9E20D2C8766549A" modified="2001-03-01" version="1">MSDIVLEPAAQDFADATAKPPLLYELGVEGARKLLDDVQSGPVEKPDVDEKWITVPVEVGDVRVRIVKPAGTTGVLPVVLYVHGGGWILGNAGTHDRLVRELAVGAEAAVVFVEYDRSPEAKYPVAIEQAYATAQWVTTKGAEEGLDGSRMVVAGDSVGGNMSAALTHMAKRRGDVTFLHQSLYYPVTDAGQDTESYRLFAHGPHLTAKAMEWFWNAYAPDPAERDQITASPLRATPEDLQGLPPAFVVVDENDVLRDEGEAYARKLIQAGVPTTSVRYNASLHDFMMLNPVRGTQASTAAIEQAIHVLRSALGTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-20" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCB1</accession>
    <name>DNLI_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lig</name>
        <name type="ordered locus">SCO1202</name>
        <name type="ORF">2SCG58.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625491.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027650.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCB1"/>
    <dbReference type="SMR" id="Q9FCB1"/>
    <dbReference type="STRING" id="100226.SCO1202"/>
    <dbReference type="PRIDE" id="Q9FCB1"/>
    <dbReference type="GeneID" id="1096625"/>
    <dbReference type="KEGG" id="sco:SCO1202"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1201"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_1_11"/>
    <dbReference type="InParanoid" id="Q9FCB1"/>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="PhylomeDB" id="Q9FCB1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006266">
        <property type="term" value="P:DNA ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000059624" description="Probable DNA ligase">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <sequence length="512" mass="54696" checksum="7A85CA68DC760FF9" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3N4</accession>
    <name>Q9K3N4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1026</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625321.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977803.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1026"/>
    <dbReference type="GeneID" id="1096449"/>
    <dbReference type="KEGG" id="sco:SCO1026"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1021"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_3_0_11"/>
    <dbReference type="InParanoid" id="Q9K3N4"/>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="PhylomeDB" id="Q9K3N4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB96011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="28544" checksum="6E3A4BCB3D181A41" modified="2000-10-01" version="1">MSENPNLLAEQRRALILDEVRRRGGVRVNELTRKLGVSDMTVRRDLDALSRQGVLEKVHGGAVPVAEASTHEPGFEAKSGLEPTAKEDIARAAAELVAPGAAIALSGGTTTYALAHRLVDVPDLTVVTNSVRVADVFHVAQRTSGARQGGATVVLTGGVRTPSDSLVGPVADQAIATLHFDALFLGVHGISAEAGLSTPNLAEAETNRRLVQSARRVVVVADHTKWGVVGLSSFAALEQVDTLVTDSGLSADARAEVAEHLGLVVAGEPEPEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3V4</accession>
    <name>Q9K3V4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628559.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029626.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4390"/>
    <dbReference type="GeneID" id="1099830"/>
    <dbReference type="KEGG" id="sco:SCO4390"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4458"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043534_0_0_11"/>
    <dbReference type="OMA" id="SEVHAQI"/>
    <dbReference type="PhylomeDB" id="Q9K3V4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="467" mass="49323" checksum="4D1DEC925E767B04" modified="2000-10-01" version="1">MSASRRSGTTDELGPDEPEQPERDGADLLAALLDGMDAALCAFDADGVVTHWNREAERILGWSAAEAVGRQGFAGWAVRSADAGEVEDRLLSAMRAPGRQVNEFALLTKDGGRVLVRTQSAAVRGPDGRPAGVYCAFSEVHAQIDLERSIALSEALLEDASWGVVLVDADLRPAVVNAHAARALGAGRTSVLGRPLGDLLAQGVEELENALTHVLAEGAPPAPAEVWVSLRTPEGERRRCWRSGFVRLASPLAEEPVPLGVGWLFQDVTESKQGEQEAALLRFRANQLHRAARAAAECEDPAEAAIVHLDFALAGFADHALIDRVVGGATSDTDAAEQVRLVRVAATPSGAPGPSVPSGTSGMPVRYGEGHPAVQCVERAGSVRASAGVRAVPAEQVRRWATARQWPEDTVHGLCAVLRSRGRTLGVVTFLRGAGRSAFERPDAMYAEDVAVRIATALDLAGAVDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K440</accession>
    <name>Q9K440_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1059</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625353.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027550.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1059"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096482"/>
    <dbReference type="KEGG" id="sco:SCO1059"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1056"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K440"/>
    <dbReference type="OMA" id="FEEGYFY"/>
    <dbReference type="PhylomeDB" id="Q9K440"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB95278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="459" mass="51001" checksum="D91CEFBB65272FC5" modified="2000-10-01" version="1">MSEYPGFPPGFVFGAATASYQIEGAATEDGRGPSIWDTYSRTPGLVVNGDTGDVACDHYHRYPEDVALLRDLGVDSYRFSIAWPRIVPDGSGAVNPKGLDFYSRLVDELLAAGIEPAATLYHWDLPQALEDRGGWRVRETAERFAEYTAVVAEHLSDRVPRWITLNEPWCSSFLGYSIGRHAPGAKEGRGALAAAHHLLVGHGLAVKALRAAGVREVGITLNLDRNLPATDSPADLAAVVRADTQHNLVWTEPILAGRYPATEEETWGELITGEDFRRDGDLELISQPLDFLGVNYYRPIVVADAPHRESDPARRVATDNRYEEVRHPGVRHTAMNWPVVPDSFTDLLVALKRQYGDALPPVHITENGSAEDDAAAADGTVHDTDRVAYLRDHLTALRAAIDAGVDVRGYYVWSLLDNFEWAYGYDKRFGIVRVDYDTQRRTPKDSYRWYREMIAANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K476</accession>
    <name>Q9K476_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7209</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631265.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031511.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7209"/>
    <dbReference type="GeneID" id="1102647"/>
    <dbReference type="KEGG" id="sco:SCO7209"/>
    <dbReference type="HOGENOM" id="CLU_3189363_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="46" mass="4746" checksum="1FF2B253BDA0C88C" modified="2000-10-01" version="1">MARARATIQAVRMSAGLRNRAVHGVCSLPMSPASPDGTNPPRDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K478</accession>
    <name>Q9K478_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7207</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631263.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971938.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7207"/>
    <dbReference type="GeneID" id="1102645"/>
    <dbReference type="KEGG" id="sco:SCO7207"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7307"/>
    <dbReference type="eggNOG" id="ENOG5033S3B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962840_0_0_11"/>
    <dbReference type="OMA" id="STDEDGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="286" mass="30797" checksum="7E24C7E4F1236D0A" modified="2000-10-01" version="1">MGLQGYLALWCGAFGSFALIGYVRSLAGVTRAQRAVRVMGRIERVREPRHGSSQHDGIPVVVSFQDPSSGEEFTVTNDGEHGERITAAWTSREIGVRYPRGRPHAYQFAGDLWAGRRGLGWPNFALFLIYVGLVVFAAVDWAWPWALIGFGGPWTGSVAWYLPQSERAVSRRLDGLASRPPVQGRVIAVLTDTSTDEDGHTSTGHTPVITFTTHEGTAVTAYCTDGLPDPAKSHGRTVTVHYTPDDPAVFTTDLAADHRSRSLDTAFGVAALLIGVAAVVVGAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXI1</accession>
    <name>Q9KXI1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2339</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028293.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2339"/>
    <dbReference type="GeneID" id="1097773"/>
    <dbReference type="KEGG" id="sco:SCO2339"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2377"/>
    <dbReference type="eggNOG" id="ENOG5033XX7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1703234_0_0_11"/>
    <dbReference type="OMA" id="NVGFYHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17032" checksum="93C302F432ABCC77" modified="2000-10-01" version="1">MTPLCRTPDTASPVDLSCGGDKATDLEGAHVLELTMAAVTAADAGATAGMQMADAPSEPDAVLRVGRDKSVCRLSTPDDWLFVSRVHLEFRCGADGTWRLSWLRGSQADPSSEVRLTIGEHRQALPYGGTVPLPRGGSGEVVVQDRAEPRSVNVGFYHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU0</accession>
    <name>Q9KXU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4301</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628473.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029566.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4301"/>
    <dbReference type="GeneID" id="1099741"/>
    <dbReference type="KEGG" id="sco:SCO4301"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4369"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_2_11"/>
    <dbReference type="OMA" id="PPLAYFE"/>
    <dbReference type="PhylomeDB" id="Q9KXU0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="279" mass="30576" checksum="DEF09A88276E05F3" modified="2000-10-01" version="1">MPGPKDLDPSSSPRALLGAELRHAREKSGLSQEELGARLFVSGSFIGQLESGTRRMQPEYARLLDDVLDTEDFFRRNCTASAKSKYPEHFAQAAEAEGTAREIKEYASMLIPGLLQTPAYARAVCRAYQPTAPDDAIEELVTARMERARMLADPTGPVLWAVVDESALRRSTGGPGVMAEALRHLAHLMRENRVIVQVLPFEAGAHPAMQGCVKLMDFADAPSLVYLEGVGTGRVDDDPATVGRYRFYYELLMVAALSTTKSLSLIEKLAQNYAHGDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU8</accession>
    <name>Q9KXU8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4293</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628465.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029562.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4293"/>
    <dbReference type="GeneID" id="1099733"/>
    <dbReference type="KEGG" id="sco:SCO4293"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4361"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_11"/>
    <dbReference type="InParanoid" id="Q9KXU8"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="PhylomeDB" id="Q9KXU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="94"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB93053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="428" mass="45183" checksum="1D944DFA9185B3DB" modified="2000-10-01" version="1">MQTAETSTNPTDAAVDLGPATALSCRECGHRVPLGPVFACEECFGPLEIAYDFSDYDAEELRKRIEAGPANIWRYAPLLPVPADVATKPNINPGWTKLVQADNLARELGVTGGLYVKDDSGNPTHSFKDRVVAQAIEAARAFGFTTLSCSSTGNLAGAVGAAAARAGFRSCVFIPHDLEQGKVVMAAVYGGELVGIEGNYDDVNRFCSELIGDPAGEGWGFVNVNLRPYYAEGSKTLAYEICEQLGWRLPDQIVVPIASGSQLTKIDKGLKELIELGLVEDRPYKIFGAQAEGCSPVSTAYKAGHDVVRPQKPNTIAKSLAIGNPADGPYVLDIARRTGGAVEDVTDEQVVDAIKLLARTEGIFAETAGGVTVGVTRKLIENGVLDPSLTTVVLNTGDGLKTLDAVAGTGLTATIRPNLDSFREAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY88</accession>
    <name>Q9KY88_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5014</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629166.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030004.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5014"/>
    <dbReference type="GeneID" id="1100455"/>
    <dbReference type="KEGG" id="sco:SCO5014"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5092"/>
    <dbReference type="eggNOG" id="ENOG5033ED0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105085_0_0_11"/>
    <dbReference type="OMA" id="PVFMQFP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176762" evidence="2">
        <location>
            <begin position="40"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="19721" checksum="6874855390474FB2" modified="2000-10-01" version="1">MGIRFAVKVRNGATGLTVAVGLALCVVGCSSGGGDDNKAEASASATAGEQSDPTAQEGTDSPLAELKGEDGLLLTIDSAERDAGGFVTVSGEIKNDGAEAARVPIQTRGDETEIMRHGGSLGGATLVDPAKKKRYYVLRDTDGRPLTTTDMPRIKPGASIPVFMQFPAPPTDTGKVTFQLPTFASAPIEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYJ6</accession>
    <name>Q9KYJ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031327.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6945"/>
    <dbReference type="GeneID" id="1102383"/>
    <dbReference type="KEGG" id="sco:SCO6945"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7051"/>
    <dbReference type="HOGENOM" id="CLU_2773991_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="7650" checksum="CAEBC23316DF15A9" modified="2000-10-01" version="1">MGYVASRVHLVRLAEATQELTAYVEHGGPGPNSKERERRWQRPTINVLRGTVFALALTCLIFAASVPRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-14" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYR6</accession>
    <name>SYP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">SCO5699</name>
        <name type="ORF">SC5H4.23</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629827.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973327.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KYR6"/>
    <dbReference type="SMR" id="Q9KYR6"/>
    <dbReference type="STRING" id="100226.SCO5699"/>
    <dbReference type="GeneID" id="1101138"/>
    <dbReference type="KEGG" id="sco:SCO5699"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5788"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYR6"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="PhylomeDB" id="Q9KYR6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000139346" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="567" mass="61252" checksum="BC076A9489F39480" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZC2</accession>
    <name>Q9KZC2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoadipyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6967</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631033.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972178.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6967"/>
    <dbReference type="GeneID" id="1102405"/>
    <dbReference type="KEGG" id="sco:SCO6967"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7067"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_2_11"/>
    <dbReference type="InParanoid" id="Q9KZC2"/>
    <dbReference type="OMA" id="NASPMND"/>
    <dbReference type="PhylomeDB" id="Q9KZC2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="7"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="275"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB89028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="395" mass="41212" checksum="CC42345DE6371E36" modified="2000-10-01" version="1">MRPVHFAAARRTPIGKLRGALSTVRPDDLAAAVLRGLVADVPALDPARVDDVYWGAANQAGEDNRNVARMAALLAGLPETVPGATVNRLCASGLEAVTTAARTIAAGEADIVLAGGSESMSRAPFVLPRPDEALPHRIETADTRLGWRLVNPAMKDLHGLLAMGETAEEVAERYGVPRERQDAFALRSHRLAAEARKNGRFDDEILPVERPDGVVVDTDECVREDTSLEKLGSLKPVFRPGGTVTAGNASPMNDGAAGLLLVSEEALNDLGLESLGRYVAGGSAGVHPDVMGIGPVPATRKVLARAGWGIGDITEAEFNEAFAAQALACVDQLGIDPDLVNPTGGAIALGHPLGCSGARILTTLLHRMRRTGAGRGLATMCVGVGQGSAVLVERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZD3</accession>
    <name>Q9KZD3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6956</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631022.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031337.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6956"/>
    <dbReference type="GeneID" id="1102394"/>
    <dbReference type="KEGG" id="sco:SCO6956"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7056"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_2_11"/>
    <dbReference type="InParanoid" id="Q9KZD3"/>
    <dbReference type="OMA" id="YVAHHIT"/>
    <dbReference type="PhylomeDB" id="Q9KZD3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="131"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="579" mass="59542" checksum="AC0055F08E03BFD3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZL4</accession>
    <name>Q9KZL4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627252.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975781.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3030"/>
    <dbReference type="GeneID" id="1098463"/>
    <dbReference type="KEGG" id="sco:SCO3030"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3090"/>
    <dbReference type="eggNOG" id="ENOG5032RR4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095649_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZL4"/>
    <dbReference type="OMA" id="SEPHSWD"/>
    <dbReference type="PhylomeDB" id="Q9KZL4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="14974" checksum="C94DD7E870199744" modified="2000-10-01" version="1">MGSRRGPLKSAVPSNIVSPVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHSERLTAPRGWEVVRLLDGSAPARPSGDDLEALANAVREAARPQERAAEARGGARSADPMEVARRGHLRVLRSPDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-30" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Q6</accession>
    <name>SYC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="synonym">cysS1</name>
        <name type="ordered locus">SCO4235</name>
        <name type="ORF">SCD8A.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628409.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029523.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0Q6"/>
    <dbReference type="SMR" id="Q9L0Q6"/>
    <dbReference type="STRING" id="100226.SCO4235"/>
    <dbReference type="GeneID" id="1099675"/>
    <dbReference type="KEGG" id="sco:SCO4235"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4297"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_11"/>
    <dbReference type="InParanoid" id="Q9L0Q6"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="PhylomeDB" id="Q9L0Q6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159490" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="2">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="4">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="6">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="6 X 14 AA tandem repeats of P-[TA]-R-G-D-K-K-R-A-[RP]-R-[PL]-G-V">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl-tRNA synthetase">
        <location>
            <begin position="148"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="613" mass="67539" checksum="2224A3EA33AC6131" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L180</accession>
    <name>Q9L180_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631447.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031635.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7397"/>
    <dbReference type="GeneID" id="1102835"/>
    <dbReference type="KEGG" id="sco:SCO7397"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7507"/>
    <dbReference type="eggNOG" id="COG5018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037266_5_1_11"/>
    <dbReference type="InParanoid" id="Q9L180"/>
    <dbReference type="OMA" id="CRELTHI"/>
    <dbReference type="PhylomeDB" id="Q9L180"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21494" checksum="DAD53554E8A82D1D" modified="2000-10-01" version="1">MDRRATVGGHAGLLNVIDLEATCWDGQPPPGEVSEIVEIGLAVVDLDARERVGRHRILVRPTRSRVSAFCTELTGITQAEADRGVSLARACDTLVREHGAGARPWASWGDYDRKQFVRQCAADGVPYPFGHPAERAHTNAKAVFTEAHGLRRRPGMAQALEIAGLPLAGRHHRGVDDAWNIAALVLRLADRDAWPGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L216</accession>
    <name>Q9L216_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630888.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031203.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L216"/>
    <dbReference type="STRING" id="100226.SCO6816"/>
    <dbReference type="GeneID" id="1102255"/>
    <dbReference type="KEGG" id="sco:SCO6816"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6925"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_5_1_11"/>
    <dbReference type="InParanoid" id="Q9L216"/>
    <dbReference type="OMA" id="GTKHGTR"/>
    <dbReference type="PhylomeDB" id="Q9L216"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176833" evidence="1">
        <location>
            <begin position="26"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB71263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="30073" checksum="1F116C0929F919C1" modified="2000-10-01" version="1">MFSKKRRLACLVTSVLAVVSLAGCADGGAGKSGALQVSGSTTVAPVAADAAEALKADGLDITVATQGGSAGGISQLASGQITIALSSKPLSEEDKAANPDTDFVSTQIGADAVGIIVTKQVADAGVKNLTADQVRDLFEGKIKNWSEVGGPDLDVFVYDKEPGRGTREVLDKYIYGDEKAPPPPESGNFAIVGGNLETRNKLESTPGAVAPLSTSFVEGRDRLAAVTLDGIEASPENIATGKYPMSRPLYLITDGKPEGTAKKFIDYVLSAKGQALMTKHDYLTLKEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9R3I8</accession>
    <accession>Q7AKS4</accession>
    <name>Q9R3I8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor sig8</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">SigB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sigB</name>
        <name evidence="8" type="ordered locus">SCO0600</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="1998-05" db="EMBL/GenBank/DDBJ databases">
            <title>Isolation and characterization of a sigB gene encoding a putative sigma factor of Streptomyces coelicolor which is highly homologous to Bacillus subtilis SigB sigma factor.</title>
            <authorList>
                <person name="Cho Y.H."/>
                <person name="Lee E.J."/>
                <person name="Roe J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">M145</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">A3</strain>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF068267">
        <property type="protein sequence ID" value="AAF23070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624912.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978261.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9R3I8"/>
    <dbReference type="STRING" id="100226.SCO0600"/>
    <dbReference type="GeneID" id="1096023"/>
    <dbReference type="KEGG" id="sco:SCO0600"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.582"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="OMA" id="RIIHMRF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF23070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="31547" checksum="6BCA22C9678E3EB3" modified="2000-05-01" version="1">MTTTTARATDHATTDMPEIADPSKVAPRDARELSKLFFEQLTVLEEGTPEHQYARNTLIEMNMSLVRFAAGRFRSRGPEEMEDIVQVGMIGLIKAIDRFELTREVEFTSFAVPYIVGEIKRFFRDTSWAVHVPRRLQEARVQLARATEELRSRLGRTPTTAELSELMSLPEDEVVEARLAANGYNSASLDAAINGSEDGESALADFIGADDAALALVDDFHALAPMIAELDERDRQIIHWRFVEELTQKDIGERLGVSQMHVSRLISRLLARLREGMLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDG4</accession>
    <name>Q9RDG4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626995.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028570.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2764"/>
    <dbReference type="GeneID" id="1098198"/>
    <dbReference type="KEGG" id="sco:SCO2764"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2821"/>
    <dbReference type="eggNOG" id="COG4222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803892_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDG4"/>
    <dbReference type="OMA" id="CRILQYN"/>
    <dbReference type="PhylomeDB" id="Q9RDG4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176869" evidence="1">
        <location>
            <begin position="36"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="35637" checksum="438FACCB1187F97D" modified="2000-05-01" version="1">MVSAMRPRMLRTSLATLTAGLAAAGCLVAAGPAAAVHDGPPRHACSPAVSLTGYSDALDKTTYDGTYAGNLSALAPDRRGALAALSDRSSLFRLDARTLKPREVIPLADENGAALDAEGLVVDRDGTYLVSSETEPSVRRYSHTGELLGRLPVPDDLRTAPEGRARANGSFEGLTLLPGGRTLLASMEYPLDGDPADLVRFQTWQRTRHGDFRLGAQYTYRTDPGLGVSEVTATPDGRLLVLERGFTAGVGNTVRLHLADRPGRGTALPKRLLADLVDCPALGATAEQPQPSPLLGNFEGMAVTGRSGGRTDVLVVSDDNQNDVQTTRFLRLRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP0</accession>
    <name>Q9RDP0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2397</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626643.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028327.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2397"/>
    <dbReference type="GeneID" id="1097831"/>
    <dbReference type="KEGG" id="sco:SCO2397"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2438"/>
    <dbReference type="eggNOG" id="COG2130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_11"/>
    <dbReference type="InParanoid" id="Q9RDP0"/>
    <dbReference type="OMA" id="GKDKCDY"/>
    <dbReference type="PhylomeDB" id="Q9RDP0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="49"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="38712" checksum="8DFBBB68991F02A3" modified="2000-05-01" version="1">MVVSEHETFSAARPSPSKPQERCPMTDSPALPAVNREWHLVTRPVGWPKPEDFALVEAEVPTPGDGQVLVRNLYVSVDPYMRGRMSAAKSYAAPYELGKPMLGGAVGEVVASNAEGIAVGDHVLHFLGWREYAAVDAKSAVKVDPDAAPLSTYLGVLGMTGLTAYAGLLRTASFKEGDSVFVSGAAGAVGSQVGQIAKLKGASRVIGSAGSDEKVKLLLDEYGFDAAFNYKNGPVSEQLRAAAPDGVDVYFDNVGGDHLEAAIGSLNLNGRIAICGAISVYNNTEPAPGPKNLARLIQTRGRIEGFLVGDHYDLQPKFVEEVGPWVRTGELKYRETVVEGIENNLEAFLGVLRGDNTGKMIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP9</accession>
    <name>Q9RDP9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2385</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626631.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028320.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2385"/>
    <dbReference type="GeneID" id="1097819"/>
    <dbReference type="KEGG" id="sco:SCO2385"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2426"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064194_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDP9"/>
    <dbReference type="OMA" id="HTEIVTW"/>
    <dbReference type="PhylomeDB" id="Q9RDP9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C_2" evidence="4">
        <location>
            <begin position="161"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="23429" checksum="5A0A3EF7F1076EEB" modified="2000-05-01" version="1">MDVHRADERYPGGDPAAGITSRHAFSFGPHYDPDNLRFGALLACNEERLAPGAGFDEHPHSHTEIVTWVVEGELTHRDSTGHETVVRAGDVQRLSAAGGVRHVERNDAAVPLTFVQMWLAPLDPGGDPAYEIVRGIADSTPYAVPEAGAMLHVRRLTAGERTAVPDGAYVYVHVVRGEVDLDGERLGPGDAARVTDAEALDAVAVTRAEVLVWEMAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIU0</accession>
    <name>Q9RIU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0967</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625264.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027478.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0967"/>
    <dbReference type="GeneID" id="1096390"/>
    <dbReference type="KEGG" id="sco:SCO0967"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.964"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RIU0"/>
    <dbReference type="OMA" id="HKENNTM"/>
    <dbReference type="PhylomeDB" id="Q9RIU0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="207" mass="20693" checksum="2D11CE4A429246F2" modified="2000-05-01" version="1">MSSISFIGLGGMAHAIAARAVSGGHSVELIGRDPAKAKSLAAELGGGATAGTFGTVPAGDIVVLAVPYTSAVPVVARYGDALAGKVIIDISNTFNADATGLVTPDGTSGAQEIAKAAPASAHVVKAFNTVFGHVLIQERRLDVLFAGDDAGAKANVSVFIESLGLRPLDVGGLEMARWLEGVGPLLMGLARNGAGTFDVALGVDFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ40</accession>
    <name>Q9RJ40_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1828</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626096.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976994.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1828"/>
    <dbReference type="GeneID" id="1097262"/>
    <dbReference type="KEGG" id="sco:SCO1828"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1850"/>
    <dbReference type="eggNOG" id="ENOG5032X86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178581_0_0_11"/>
    <dbReference type="OMA" id="FEVHAQG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="8352" checksum="86EA16403CC7B7A1" modified="2000-05-01" version="1">MATCEVCGNNYGMTFEVHAQGAVHVFDCFSCAIHRMAPICEHCRVQIIGQGVEVDGHWFCGAHCARAEGRAGIVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJN4</accession>
    <name>Q9RJN4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0610</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624922.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027244.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0610"/>
    <dbReference type="GeneID" id="1096033"/>
    <dbReference type="KEGG" id="sco:SCO0610"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.592"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RJN4"/>
    <dbReference type="OMA" id="FRFFRFE"/>
    <dbReference type="PhylomeDB" id="Q9RJN4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="27295" checksum="69A14F945B9829F5" modified="2000-05-01" version="1">MTRVTVSAMDHHGGRPRAERARALADALRQQITDDAFADGVLPDERDLGRRFGASRNAVRDALALLREEGLITRRRGVGTTVLLPKYAHGLDRLTGLAEELTGRGTVTNEVRVAVEVPALPAAIASRLEVPAGAGGVYVERLRRLDGLPLSLDTSYLTVDVGRAVLAGDLRDRDVFGLIEEAAGARLGRAEVAVHAVNADPGTARLLGIGPGAAVFALERLTRLADGRPVDAESIRIRADRMALRATLRRGGPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJT6</accession>
    <name>Q9RJT6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0374</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
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                <person name="Hidalgo J."/>
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                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
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    <accession>Q9RJY1</accession>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
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                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
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                <person name="Chen C.W."/>
                <person name="Collins M."/>
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                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
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                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
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                <person name="Howarth S."/>
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                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="8446" last="8451">
            <title>Structural and functional characterization of a conserved pair of bacterial cellulose-oxidizing lytic polysaccharide monooxygenases.</title>
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                <person name="Forsberg Z."/>
                <person name="Mackenzie A.K."/>
                <person name="Sorlie M."/>
                <person name="Rohr A.K."/>
                <person name="Helland R."/>
                <person name="Arvai A.S."/>
                <person name="Vaaje-Kolstad G."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1402771111"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 35-230 IN COMPLEX WITH COPPER</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2018" name="J. Biol. Chem." volume="293" first="13006" last="13015">
            <title>The carbohydrate-binding module and linker of a modular lytic polysaccharide monooxygenase promote localized cellulose oxidation.</title>
            <authorList>
                <person name="Courtade G."/>
                <person name="Forsberg Z."/>
                <person name="Heggset E.B."/>
                <person name="Eijsink V.G.H."/>
                <person name="Aachmann F.L."/>
            </authorList>
            <dbReference type="PubMed" id="29967065"/>
            <dbReference type="DOI" id="10.1074/jbc.RA118.004269"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 261-364</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
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        <property type="protein sequence ID" value="CAB61600.1"/>
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        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=35-230"/>
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        <property type="chains" value="A=261-364"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176916" evidence="2">
        <location>
            <begin position="35"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="258"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Copper</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Copper</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="103"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="265"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4OY7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6F7E"/>
        </source>
    </evidence>
    <sequence length="364" mass="38085" checksum="9E1B1A699A9AB783" modified="2000-05-01" version="1">MVRRTRLLTLAAVLATLLGSLGVTLLLGQGRAEAHGVAMMPGSRTYLCQLDAKTGTGALDPTNPACQAALDQSGATALYNWFAVLDSNAGGRGAGYVPDGTLCSAGDRSPYDFSAYNAARSDWPRTHLTSGATIPVEYSNWAAHPGDFRVYLTKPGWSPTSELGWDDLELIQTVTNPPQQGSPGTDGGHYYWDLALPSGRSGDALIFMQWVRSDSQENFFSCSDVVFDGGNGEVTGIRGSGSTPDPDPTPTPTDPTTPPTHTGSCMAVYSVENSWSGGFQGSVEVMNHGTEPLNGWAVQWQPGGGTTLGGVWNGSLTSGSDGTVTVRNVDHNRVVPPDGSVTFGFTATSTGNDFPVDSIGCVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK39</accession>
    <name>Q9RK39_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0340</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624664.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978526.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095763"/>
    <dbReference type="KEGG" id="sco:SCO0340"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.314"/>
    <dbReference type="eggNOG" id="ENOG5033CHR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420701_0_0_11"/>
    <dbReference type="OMA" id="QVAGIMH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="20977" checksum="356F15DE4DB6ABE5" modified="2000-05-01" version="1">MGAMSRTTAALRLRRAITRTRDATRERAPVGRRPEEADDVRGTFATDGALGFDPFPFLRALHDAGSHAVVIGQVAGIMHGSTELTGDLDLLWDGTPAEARALRSALAACGCAEPPDLDRAQAAYEVTGAGGDLCTPALPWGDMDVSPCLARAETTHDPSGFTVRYAALDDLIRMRRALGRPKDHRRADELTRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK93</accession>
    <name>Q9RK93_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0269</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624599.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026974.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0269"/>
    <dbReference type="GeneID" id="1095693"/>
    <dbReference type="KEGG" id="sco:SCO0269"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.243"/>
    <dbReference type="eggNOG" id="ENOG502Z81U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010573_0_0_11"/>
    <dbReference type="OMA" id="HLRLRFH"/>
    <dbReference type="PhylomeDB" id="Q9RK93"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="50"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Lant_dehydr_C" evidence="2">
        <location>
            <begin position="780"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114471" checksum="6A83C098E9A03275" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKW1</accession>
    <name>Q9RKW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6215</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB61317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630317.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1101656"/>
    <dbReference type="KEGG" id="sco:SCO6215"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6329"/>
    <dbReference type="HOGENOM" id="CLU_3277070_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="41" mass="4799" checksum="E89D41B6993F7284" modified="2000-05-01" version="1">MARELHASLQQLTDWAERNRLYVAEARAAYDTEHRPELTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL11</accession>
    <name>Q9RL11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0307</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027004.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0307"/>
    <dbReference type="DNASU" id="1095731"/>
    <dbReference type="GeneID" id="1095731"/>
    <dbReference type="KEGG" id="sco:SCO0307"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.282"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RL11"/>
    <dbReference type="OMA" id="DFRRWWG"/>
    <dbReference type="PhylomeDB" id="Q9RL11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="32189" checksum="91AF744D77736075" modified="2000-05-01" version="1">MSSELGDFLKARRRELSPPTAGLPADGRRRVPGLRREEVAVLASISPGHYTRLEQGRRRASEPVLDALARALRLSADERAYLFELSGKDAGRPLGRPGRQVRPQLRRLLDDLTHTPALVLGRCTDILAWNPPAAALFTDFALLSRDERNFVRLVFRDPAVRALYTDWPYMARACVAQLRMEAARDPHDPRLSALVAELSAQDPDFRTWWKDHRVAVRGAGTKDLRHPVIGELTLDWSALTDTADPDQQLIALTAAPGTPSHDGLRALRDLGAVTSGRTGPGVPGGGGEIAGASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1N5</accession>
    <accession>Q7AKN6</accession>
    <name>Q9S1N5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaG gene and flanking genes</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2469</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="1999-07" db="EMBL/GenBank/DDBJ databases">
            <title>Characterisation of the essential dnaG locus of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Flett F."/>
                <person name="Jungmann-Campello D.M."/>
                <person name="Smith C.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">MT1110</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AJ244019">
        <property type="protein sequence ID" value="CAB51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626711.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976335.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2469"/>
    <dbReference type="GeneID" id="1097903"/>
    <dbReference type="KEGG" id="sco:SCO2469"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2510"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_0_11"/>
    <dbReference type="OMA" id="IATYPYH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="421" mass="45226" checksum="E472942193DD1EC8" modified="2000-05-01" version="1">MVDADQTFVIVGGGLAGAKAAETLRTEGFTGRVILVCDERDHPYERPPLSKGYLLGKEERDSVFVHEPAWYARHDIELHLGQTVVAIDRAAKTVHYGDDGTHVSYDKLLIATGAEPRRLDVPGTGLAGVHHLRRLAHAERLKGVLATLGRDNGHLVIAGAGWIGLEVAAAAREYGAEVTVIEPAPTPLHGVLGPELGAVFAELHESRGVRFRFGVKLTEIVGQDGVVLAARTDDGEEHPAHDVLAAIGAAPRTALAQAAGLEIADRAHGGGIVVDDHLRTSDPDIFAAGDVASFHHALFDTSLRVEHWANALNGGPAAARAMLGRGLAHDRVPYFFTDQYDLGMEYSGWAPAGSYDQVVIRGDAAKREFIAFWVKEGRVLAGMNVNVWDVTEPIQQLIRSKTRVDTEDLANPHVSLESLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1V9</accession>
    <name>Q9S1V9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0033</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37097">
        <property type="entry name" value="T37097"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624391.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026793.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0033"/>
    <dbReference type="CAZy" id="GH33">
        <property type="family name" value="Glycoside Hydrolase Family 33"/>
    </dbReference>
    <dbReference type="GeneID" id="1095466"/>
    <dbReference type="KEGG" id="sco:SCO0033"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.27"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371685_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S1V9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007132">
        <property type="entry name" value="DUF346"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03984">
        <property type="entry name" value="DUF346"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="748" mass="79061" checksum="20E829A5AB867571" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S279</accession>
    <name>Q9S279_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1810</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36774">
        <property type="entry name" value="T36774"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626079.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977012.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1810"/>
    <dbReference type="GeneID" id="1097244"/>
    <dbReference type="KEGG" id="sco:SCO1810"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1831"/>
    <dbReference type="eggNOG" id="ENOG5031WUA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180858_0_0_11"/>
    <dbReference type="OMA" id="IRLPWWA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="68" mass="7387" checksum="ABCF16786F23FB90" modified="2000-05-01" version="1">MSAPTHTRPPRATRGGVDARLPWWALALPVLAFVALLLLILNPADARAAAEQPATAHLLERLEQLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2A8</accession>
    <name>Q9S2A8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1722</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36744">
        <property type="entry name" value="T36744"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625995.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977104.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1722"/>
    <dbReference type="GeneID" id="1097153"/>
    <dbReference type="KEGG" id="sco:SCO1722"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1739"/>
    <dbReference type="eggNOG" id="COG5343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075802_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2A8"/>
    <dbReference type="OMA" id="RASERWF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB50937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="26008" checksum="F45B86CB3F0CBBEF" modified="2000-05-01" version="1">MSLFGHSLAAPYALDALEGAERVRFERHLEGCARCAAEVRALSEDAVRLARSTAAPAPPALRERVLAAVRTTAQEPAPARGPVPRRSVGHVRPRPLLVPFATVTAAAALVVASLFAVRADRTRDELATARDRAREIAHVLAAPDARAARGADARGRGVAVVASASRGRAVVTLSGYGEPPGDRVRQLWVMRPGAEPRSLGLFDGDTPLVAAGLSRSATSLAVTVEPGGGSDLPTTEPVVQLALESVGFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2J7</accession>
    <name>Q9S2J7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35751">
        <property type="entry name" value="T35751"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626267.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028090.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2006"/>
    <dbReference type="GeneID" id="1097440"/>
    <dbReference type="KEGG" id="sco:SCO2006"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2037"/>
    <dbReference type="eggNOG" id="ENOG50320SH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141067_0_0_11"/>
    <dbReference type="OMA" id="NRQYDIL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="18420" checksum="BBDF11CAD85F9721" modified="2000-05-01" version="1">MGRGGGPRPGAAAVRHRVVRGRAVPGADVRASATPPPHPARSLARTLTLALLIGVSSAGCGGGPHDPTGGSAGTAPSASPPPPSGASSGPPLPLSGAELCVSAVGYWAREILDGGVPYGDYQSMGLSNRQYDILREVVAAARVAKREQGARAAGELTDRQVRRTCAERYRDGGPSVGPWQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX14</accession>
    <name>REX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rex</name>
        <name type="ordered locus">SCO3320</name>
        <name type="ORF">SCE68.18c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="EMBO J." volume="22" first="4856" last="4865">
            <title>A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Brekasis D."/>
                <person name="Paget M.S.B."/>
            </authorList>
            <dbReference type="PubMed" id="12970197"/>
            <dbReference type="DOI" id="10.1093/emboj/cdg453"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
        <scope>MUTAGENESIS OF GLY-102</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Modulates transcription of respiratory genes in response to changes in cellular NADH/NAD(+) redox state. May play a general role as a sensor of cellular redox balance.</text>
    </comment>
    <comment type="subunit">
        <text>Homodimer.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-15532671">
            <id>Q9WX14</id>
        </interactant>
        <interactant intactId="EBI-15532671">
            <id>Q9WX14</id>
            <label>rex</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36268">
        <property type="entry name" value="T36268"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975516.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9WX14"/>
    <dbReference type="SMR" id="Q9WX14"/>
    <dbReference type="DIP" id="DIP-48429N"/>
    <dbReference type="STRING" id="100226.SCO3320"/>
    <dbReference type="GeneID" id="1098754"/>
    <dbReference type="KEGG" id="sco:SCO3320"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3380"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_0_1_11"/>
    <dbReference type="InParanoid" id="Q9WX14"/>
    <dbReference type="OMA" id="HEQRKAG"/>
    <dbReference type="PhylomeDB" id="Q9WX14"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="IntAct"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000097916" description="Redox-sensing transcriptional repressor Rex">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Loss of redox sensing." evidence="3">
        <original>G</original>
        <variation>A</variation>
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12970197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="258" mass="26809" checksum="84B82E3CDB4432A6" modified="1999-11-01" version="1">MATGRAHRPATRSRGIPEATVARLPLYLRALTALSERSVPTVSSEELAAAAGVNSAKLRKDFSYLGSYGTRGVGYDVEYLVYQISRELGLTQDWPVVIVGIGNLGAALANYGGFASRGFRVAALIDADPGMAGKPVAGIPVQHTDELEKIIQDDGVSIGVIATPAGAAQQVCDRLVAAGVTSILNFAPTVLNVPEGVDVRKVDLSIELQILAFHEQRKAGEEAAADGAAPPVAARKQQRSTGSADQGPDGDVPAVMPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX29</accession>
    <name>SYR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Arginine--tRNA ligase</fullName>
            <ecNumber>6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginyl-tRNA synthetase</fullName>
            <shortName>ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">argS</name>
        <name type="ordered locus">SCO3304</name>
        <name type="ORF">SCE68.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36252">
        <property type="entry name" value="T36252"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627514.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028896.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9WX29"/>
    <dbReference type="SMR" id="Q9WX29"/>
    <dbReference type="STRING" id="100226.SCO3304"/>
    <dbReference type="GeneID" id="1098738"/>
    <dbReference type="KEGG" id="sco:SCO3304"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3365"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_5_1_11"/>
    <dbReference type="InParanoid" id="Q9WX29"/>
    <dbReference type="OMA" id="HHIGDWG"/>
    <dbReference type="PhylomeDB" id="Q9WX29"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000151616" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="586" mass="64704" checksum="6EA6F2158A7CB91D" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X835</accession>
    <name>Q9X835_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6068</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35860">
        <property type="entry name" value="T35860"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972853.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6068"/>
    <dbReference type="GeneID" id="1101509"/>
    <dbReference type="KEGG" id="sco:SCO6068"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6169"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_2_1_11"/>
    <dbReference type="InParanoid" id="Q9X835"/>
    <dbReference type="OMA" id="AYQMNML"/>
    <dbReference type="PhylomeDB" id="Q9X835"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="14427" checksum="D2A67F92A8B0E086" modified="1999-11-01" version="1">MTRPSPATHTELDQLLTGLVERVADVNQAVVLSEDGLVVSKSTGFLRDDAERLAATASGLMSLSKGVSMDFRGGPVRQALIEMANSYLILTSAGPGAHLVVLTGPNADVGVVAYQMNMLVKKIGEHLSAAPRATAGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8A7</accession>
    <name>Q9X8A7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3531</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36172">
        <property type="entry name" value="T36172"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627731.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029067.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3531"/>
    <dbReference type="GeneID" id="1098967"/>
    <dbReference type="KEGG" id="sco:SCO3531"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3588"/>
    <dbReference type="eggNOG" id="ENOG5030RJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094228_0_0_11"/>
    <dbReference type="OMA" id="YTMREGA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="28538" checksum="2443033969F44435" modified="1999-11-01" version="1">MNDILDFGLDDLSPVDDDSEEAMEALWTGDLTVLSQHHTTPNGSHSFILAHDRSVTWGIPGEPQLVAIAVARDLRQSTFTFETSHHATASFAQNWLAERGCPLERIALRGGDYIEPADDLTLQVEQQIQNSGTRYEVLDTYTSDDNPSEAWTLVNDSQATQAPVRLFYEKWNHGADTYTMREGAFPDVGVAQTWLDERSEPLPEPPEYSDHNGAVVRARIARIALSRSAATSPTPQTGLDTPRASAAVPVQRAVQGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8F3</accession>
    <name>Q9X8F3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36240">
        <property type="entry name" value="T36240"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627492.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028883.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3280"/>
    <dbReference type="GeneID" id="1098714"/>
    <dbReference type="KEGG" id="sco:SCO3280"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3340"/>
    <dbReference type="eggNOG" id="ENOG502ZV2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100611_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8F3"/>
    <dbReference type="OMA" id="TTPVNKW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="3">
        <location>
            <begin position="62"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB40338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="21323" checksum="E3917072E54B1A74" modified="1999-11-01" version="1">MTGPPPGLDTPRGYIFCVMDHDMDHSTHHSAPEDDGPGHPHGHGHLHGPGHPHGHVHVHGTTWATAMQATLHCLTGCAIGEILGMVIGTALMWGNVPTMVLAIALAFVFGYSLTLFAVVRAGVSMKAAIKVALAADTVSIAVMELVDNGIIALVPGAMEAHLSDGLFWYALLGGFAVAFVITTPVNKWMIGRGKGHAVVHAYH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8I0</accession>
    <name>FOLB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Dihydroneopterin aldolase</fullName>
            <shortName>DHNA</shortName>
            <ecNumber>4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">folB</name>
        <name type="ordered locus">SCO3400</name>
        <name type="ORF">SCE9.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36326">
        <property type="entry name" value="T36326"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028954.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8I0"/>
    <dbReference type="SMR" id="Q9X8I0"/>
    <dbReference type="STRING" id="100226.SCO3400"/>
    <dbReference type="GeneID" id="1098837"/>
    <dbReference type="KEGG" id="sco:SCO3400"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3463"/>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112632_1_1_11"/>
    <dbReference type="InParanoid" id="Q9X8I0"/>
    <dbReference type="OMA" id="GHYKSVA"/>
    <dbReference type="PhylomeDB" id="Q9X8I0"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0289">Folate biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000168287" description="Dihydroneopterin aldolase">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AC16"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="119" mass="13002" checksum="0E865735FA1A694D" modified="1999-11-01" version="1">MDRVALRGLKARGHHGVFPKEREDGQTFLVDIVLGLDTRPAAADDDLAKTVHYGIVAEEVVAVVEGEPVNLVETLAERIAQVCLKHEGVEEVEVCVHKPDAPITVPFDDVTVTIIRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8N0</accession>
    <name>Q9X8N0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3374</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36385">
        <property type="entry name" value="T36385"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627582.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028943.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3374"/>
    <dbReference type="GeneID" id="1098811"/>
    <dbReference type="KEGG" id="sco:SCO3374"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3437"/>
    <dbReference type="eggNOG" id="ENOG50341YZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075567_1_0_11"/>
    <dbReference type="OMA" id="TECHRAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="24310" checksum="D9C29A2C323558BE" modified="1999-11-01" version="1">MVGASHSVPLAPASPVVPSPRRPTGNGGSARERTRWWYESVLGWPTAPGEPVRLRTGIRFDVLDVPAAAGYATLERLGWSGRGPQGFPVAVRGERMLLLVAAGGAEELPGLLEWLEWGSLALDLTAVGADGLVEAPLAPVVPETRPAGPPPRPPGRDGVRGAAVWLRPPEPGCEAESSLPALSALGGAGTALDLVRLVRTLATQCHRVRLTADRSPRARPETRPMAPPVAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8T3</accession>
    <name>Q9X8T3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3897</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36584">
        <property type="entry name" value="T36584"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628083.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029299.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3897"/>
    <dbReference type="GeneID" id="1099333"/>
    <dbReference type="KEGG" id="sco:SCO3897"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3970"/>
    <dbReference type="eggNOG" id="ENOG5033IIV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136826_0_0_11"/>
    <dbReference type="OMA" id="QAGVGDC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="20317" checksum="DCC41852B19B3CFE" modified="1999-11-01" version="1">MGPGSLRASYLAACPRHAPISGGPPVTTQPPPQGNPFAQNQPQAPQQPQGQNPYAQGQPGFPQQAGQPGQPGFPQQGAPYAPVPPQPARRKPSFKTIKNIVIAVVVVGVAVGGYIASRDDADQAGVGDCLKSASSSSDRMEVVDCSSSDAKGKVLSKVKGHFTSVTAETECRKVDGATGFYAETGDGEEFLLCLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8T4</accession>
    <name>Q9X8T4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3898</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36585">
        <property type="entry name" value="T36585"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628084.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029300.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3898"/>
    <dbReference type="TCDB" id="2.A.1.21.16">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="GeneID" id="1099334"/>
    <dbReference type="KEGG" id="sco:SCO3898"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3971"/>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052021_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8T4"/>
    <dbReference type="OMA" id="MRFCYGA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="425" mass="44103" checksum="372C95CAF4ACBE2A" modified="1999-11-01" version="1">MAVVRDLRVLLRLKGFRRLLAVRLLSQGADGVYQVALATYVVFSPEKQTSPAAIASAMAVLLLPYSLVGPFAGVLLDRWRRRQVFLYGNLLRAALASVTAALMIASVPDWLFYVSALCVTAVNRFVLAGLSAALPRVVDAERLVIANSLSPTAGTLAATAGGGLAFVVRLVVSDSDAAVVLLGAGLYLCGALASLRIAVELLGPDRALGPPRLTSALNGTARDLVAGVRHLAAPARREAAWALAAMTLMRFCYGALLVMLLMLCRYSLTSDTDEGLALLGLALGVSGAGFFAAAVVTPWAAGRLGPGRWMAVCAAVATVLVPALGLPFAAAPLLAAAFVLGLTTQGAKIATDTVVQSSVDDTFRGRIFSVYDVLFNVAFVGAAGVAALMLPPDGRSVPLVVTVAAIYGVVAAAMARFESRQVSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X922</accession>
    <name>Q9X922_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative septum site determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3557</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36678">
        <property type="entry name" value="T36678"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627755.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029084.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3557"/>
    <dbReference type="GeneID" id="1098993"/>
    <dbReference type="KEGG" id="sco:SCO3557"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3613"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042654_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X922"/>
    <dbReference type="OMA" id="DLDPWGG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051782">
        <property type="term" value="P:negative regulation of cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="396" mass="40620" checksum="C4D76126BFCB09E4" modified="1999-11-01" version="1">MTGTITHDPPSAAGGRQGGPLIVTEDTELLDDLLRLCAAAGATPEVHHSVPVTPPSAPSVLTAVASSASPAPAAAGRRTGWETAPLVLVGDDAARRVRGAVRRRGVVLVGRDQDDSGIWQRAVEIGADHVLMLPDGEQWLVDRIADVAEGVGRPALTVGVIGGRGGAGASTLACALAVTSAREGLRSLLVDADPLGGGLDVLLGGETAEGLRWPAFAASRGRVGGGALEESLPQLHSLRVLSWDRGDCVAVPPQAVRAVLAAARRRGGTVVVDLPRRIDDGVAEVLAQLDIGLLVVPAELRAVAAAGRVAAAVGMVLRDLRVVVRGPYGSGLDDREVARLLGLPLAGEVPVESGLLRATESRRPPGTPTRGPLARFCRGFWERALAETDGRGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA32</accession>
    <name>Q9XA32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3832</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36701">
        <property type="entry name" value="T36701"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628020.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029258.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3832"/>
    <dbReference type="GeneID" id="1099268"/>
    <dbReference type="KEGG" id="sco:SCO3832"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3901"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_1_11"/>
    <dbReference type="OMA" id="DHERAGH"/>
    <dbReference type="PhylomeDB" id="Q9XA32"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14942" checksum="1D6D61E5AACAEFAE" modified="1999-11-01" version="1">MLQADGRASIRSVAERVHVSRANAYARINRLVEDGVIRGFGARVDHERAGHGTSAYITLKIVQNSWRTVRAQLRQLPGASHIALVGGDFDVLLLVHTPDNRALRELVLSRLQAIPEVLSTRTLLVFETEDLEPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA52</accession>
    <name>Q9XA52_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ion channel membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3826</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36507">
        <property type="entry name" value="T36507"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628015.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975108.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3826"/>
    <dbReference type="TCDB" id="1.A.1.13.5">
        <property type="family name" value="the voltage-gated ion channel (vic) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099262"/>
    <dbReference type="KEGG" id="sco:SCO3826"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3895"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055253_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XA52"/>
    <dbReference type="OMA" id="HIIVCGC"/>
    <dbReference type="PhylomeDB" id="Q9XA52"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="365" mass="39391" checksum="16E0A7A5A5709B2C" modified="1999-11-01" version="1">MKLPGQDAIARQADEHFVTYKVKLPRKLVEHPFRQVAKRLSIALLVLVVTAVIVYADHDGYTDNSDGSVDLLDSFYYATVTLSTTGYGDITPVSDAARLTNIFVITPLRVLFLIILVGTTLEALTERTREEWRLNRWRSALRDHTVVVGFGTKGRSAIQTVCATGLRKDQVVVVDPSGKAIEAATAHGYAGVVGDATRSDVLNRAEAYRAKQIIIATQRDDTAVLVTLTARQLNRGAKIVVAVREEENAPLLKQSGADAVITSASAAGRLLGLSVLSPAAGMVMEDLISQGSGLDLVERPVIKAEVGKHPREMDDLVVSVLRGHRVLGYDDPAVGGLELADRLITIVRATPATHVAPDARPLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA58</accession>
    <name>Q9XA58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3819</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36500">
        <property type="entry name" value="T36500"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628008.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029249.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3819"/>
    <dbReference type="GeneID" id="1099255"/>
    <dbReference type="KEGG" id="sco:SCO3819"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3887"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120982_1_0_11"/>
    <dbReference type="OMA" id="LWSVQFT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB46942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14598" checksum="CA5F00B10188165B" modified="1999-11-01" version="1">MPSDEQLAVGLLGRTAYGRAATTLRALPFLAHARHIVADGRVLLRMPRSWGYHRVCAGSVVAYGADNLTSARPGESLWTVQVVGRCETHEPSAAELERFGPTPDRVDGEPFEPAYLRVDPQFGTVHFTDGSAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAK4</accession>
    <name>Q9XAK4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3598</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35366">
        <property type="entry name" value="T35366"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627793.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975341.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3598"/>
    <dbReference type="MEROPS" id="G05.004"/>
    <dbReference type="GeneID" id="1099034"/>
    <dbReference type="KEGG" id="sco:SCO3598"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3655"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAK4"/>
    <dbReference type="OMA" id="DWIHIAV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="26808" checksum="A32BF8CA23CD9E58" modified="1999-11-01" version="1">MVIAFAVSWLSWGTAIVLGGTETNEAANAPYMLGAFGPLIGAFVIRVRRRRRGEPVPEHAVPFRAALLLKAVLLLVLGSATVLAAALLASRAGGPELSLDVAKDAVEDFGGPAAFLVGMLVSGPLSEEPGWRGTAYPRLREKLGTLQVCLVLGVTWAVWHLPLFFIDGTVQHDLGLATPSGVLFVVSNIPMAMLVTAAYERAGIAASIAVHFAVNATMILLAVEEPEVQAMILGIQALTVTALLLTHRTGRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Z3</accession>
    <name>Q9Z4Z3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36186">
        <property type="entry name" value="T36186"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028848.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3238"/>
    <dbReference type="GeneID" id="1098672"/>
    <dbReference type="KEGG" id="sco:SCO3238"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3302"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041665_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z4Z3"/>
    <dbReference type="OMA" id="HYHVPLH"/>
    <dbReference type="PhylomeDB" id="Q9Z4Z3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="386" mass="41152" checksum="18D9828E124DC502" modified="1999-05-01" version="1">MRLRHRDGTTVHLAYCTNVHAAEDLDGVLAQLARYGEPVRERLGADRIGLGLWLAAPVVTALAADRSALDLLRKELDLRGIEVVTLNAFPYAGFHAPTVKKAVYRPDWTERPRLDHTLACARVLAELLPPDAARGSVSTLPLAWRTPWTPRRDDLARRHLDLLSQGLAALNADTGRTVRVGFEPEPGCLIETTGQAVARLAGADPERLGVCVDTCHLAVAFEEPGPALTRLAAALPVVKTQASCAVHADRPADPAARAALAAFAERRFLHQTRQAAPGGPSAVDDLPEALGGALNGDAAWRIHYHVPVQRDLPPPLRSTRPELVAALTTLLGGPTALTDHVEVETYTWPVLPGAPDGGGLVDGIAGELAWTRSALTALGLTEESTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBH3</accession>
    <name>Y6440_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative (5-formylfuran-3-yl)methyl phosphate synthase</fullName>
            <ecNumber evidence="1">4.2.3.153</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase</fullName>
            <shortName evidence="1">4-HFC-P synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO6440</name>
        <name type="ORF">SC9B5.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:83407"/>
            <dbReference type="EC" id="4.2.3.153"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MfnB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.153" evidence="1"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35927">
        <property type="entry name" value="T35927"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972538.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBH3"/>
    <dbReference type="SMR" id="Q9ZBH3"/>
    <dbReference type="STRING" id="100226.SCO6440"/>
    <dbReference type="GeneID" id="1101879"/>
    <dbReference type="KEGG" id="sco:SCO6440"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6540"/>
    <dbReference type="eggNOG" id="COG1891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068659_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBH3"/>
    <dbReference type="OMA" id="NFPWVIR"/>
    <dbReference type="PhylomeDB" id="Q9ZBH3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007565">
        <property type="entry name" value="4HFCP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04476">
        <property type="entry name" value="4HFCP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015957">
        <property type="entry name" value="UCP015957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000134871" description="Putative (5-formylfuran-3-yl)methyl phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q58499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="250" mass="26177" checksum="1A249A6F2AE72F3F" modified="1999-05-01" version="1">MLLLISPDGVDEALDCAKAAEHLDIVDVKKPDEGSLGANYPWVIREIRAAVPADKPVSATVGDVPYKPGTVAQAALGAAVSGATYIKVGLYGCATPEQAVEVMRGVVRAVKDHRADAFVVASGYADAHRIGCVNPLSLPDIARRSGSDAAMLDTAIKDGTRLFDHVPPDVCAEFVRRAHDCGLLAALAGSVRSGDLGELARIQTDIVGVRGAVCEGGDRTTGRIRPHLVAAFRAEMDRHVREHAAAAAQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBR5</accession>
    <name>RL28A_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L28-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmB1</name>
        <name type="ordered locus">SCO5564</name>
        <name type="ORF">SC7A1.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35648">
        <property type="entry name" value="T35648"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBR5"/>
    <dbReference type="SMR" id="Q9ZBR5"/>
    <dbReference type="STRING" id="100226.SCO5564"/>
    <dbReference type="GeneID" id="1101005"/>
    <dbReference type="GeneID" id="67396284"/>
    <dbReference type="KEGG" id="sco:SCO5564"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5653"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBR5"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="PhylomeDB" id="Q9ZBR5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178560" description="50S ribosomal protein L28-1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="61" mass="6639" checksum="8E49BCB518A31B09" modified="1999-05-01" version="1">MAANCDVCGKGPGFGNNISHSHRRTSRRWNPNIQRVRTVVSGTPKRVNACTSCIKAGKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O50526</accession>
    <name>O50526_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tagatose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35888">
        <property type="entry name" value="T35888"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629975.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030498.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5852"/>
    <dbReference type="GeneID" id="1101294"/>
    <dbReference type="KEGG" id="sco:SCO5852"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5951"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_11"/>
    <dbReference type="InParanoid" id="O50526"/>
    <dbReference type="OMA" id="NNMEIVQ"/>
    <dbReference type="PhylomeDB" id="O50526"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA15809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="28893" checksum="6CD7D08381E2DF73" modified="1998-06-01" version="1">MPLVPTRELVSEAAVAGRAVAAFNVITLEHAEAIASGAQAAGAPVILQISENAVRFHGGRVEPIARAAAEVGKACGVDVALHLDHVTDPRLLHGAADAGFSSAMFDAGAQPYAENLAATRAAAQWAHGAGLWLEAELGYVGGKPDAPASAHAAGVRTDPQEAARYVADTGVDALAVAVGSSHAMTERSASLDHALIERLREAVPVPLVLHGSSGVGDDELRRAVRAGILKVNVGTALNIAFTGAVRETLAARPDLTDPRPYVARGREAMAETVRALLAVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O54158</accession>
    <name>O54158_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5895</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34921">
        <property type="entry name" value="T34921"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630016.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973125.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="SMR" id="O54158"/>
    <dbReference type="STRING" id="100226.SCO5895"/>
    <dbReference type="GeneID" id="1101337"/>
    <dbReference type="KEGG" id="sco:SCO5895"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5994"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065363_0_0_11"/>
    <dbReference type="InParanoid" id="O54158"/>
    <dbReference type="OMA" id="AFNAFMT"/>
    <dbReference type="PhylomeDB" id="O54158"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="193"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="362" mass="39394" checksum="ABE8FEB4C0A3E3CF" modified="1998-06-01" version="1">MDILSLAKSVGSRVEAPLTDLRTVTKVLGNPHMPLLLALSKGFVEPVYRAAFLASAASSGVLAALAVRPCDLESLAERLDIDDEDLPRLKEWLDMGIRLGDLGKREGCYKLRSLPAKALAQPGNDAIAAALEEVLRFHVPALLNGPRMLREGRRFSLDDQDGLVIARSTRVIQPLVEEAIARTLDRNAPVRLLEVGCGSGTYVRYAAELNPRLSALAVDLQQDVADSAAANMAEWGLTDRVETRQADLRTLDAQPQFDLVTLHNNIYYFPEAERVEALRRAHDLLAPGGRLLLTTSCKGGNVGLEALNLWFTYADFGGPLPQADALADQLRQAGFDDVEATRIVPGEQFHAFTGTSKRVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>O69878</accession>
    <name>O69878_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5590</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34775">
        <property type="entry name" value="T34775"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629724.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973403.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5590"/>
    <dbReference type="GeneID" id="1101031"/>
    <dbReference type="KEGG" id="sco:SCO5590"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5682"/>
    <dbReference type="eggNOG" id="ENOG5033B7F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114077_0_0_11"/>
    <dbReference type="OMA" id="VCDCGRN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21137" checksum="97604E1B7DDDD985" modified="1998-08-01" version="1">MSTTPPVLAAELAQAWADIQRHHTELPDLAAPESLIGESSSACGHELSFERLLHEAVHGIAAARGVRDTSRAGRYHNRRFLAIAEELGLDHPEEPHPSSGFSLVTLTPEAKRRYRPTIERLQRALKAHTVATATDTARSFRGPAARHGSSGGGVRVKAVCDCGRNVRVVPSVLAQAPIMCGGCGKPFRIPEVVGAGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O86686</accession>
    <name>O86686_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35049">
        <property type="entry name" value="T35049"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031066.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6640"/>
    <dbReference type="GeneID" id="1102079"/>
    <dbReference type="KEGG" id="sco:SCO6640"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6745"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_2_0_11"/>
    <dbReference type="InParanoid" id="O86686"/>
    <dbReference type="OMA" id="AMLIGVK"/>
    <dbReference type="PhylomeDB" id="O86686"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="44"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="268"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="731" mass="80247" checksum="E19079945923C3CA" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O86708</accession>
    <name>O86708_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6526</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35218">
        <property type="entry name" value="T35218"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630607.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030988.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6526"/>
    <dbReference type="GeneID" id="1101965"/>
    <dbReference type="KEGG" id="sco:SCO6526"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6629"/>
    <dbReference type="eggNOG" id="ENOG5033WVD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155290_0_0_11"/>
    <dbReference type="OMA" id="HAMCARW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14655" checksum="E36AACFE4763310B" modified="1998-11-01" version="1">MGPVRVTAIASLTPLEQLDDDPFLVDSRSQHAMCARWAAEHGYVVARQLLVRGLRPDHDALWDGVRPGHDLFVAPSRRVLESALSSVDAFSAECARRGVRVETVGQAEPSYDARMKACVHRRLSMPTAGYDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O86720</accession>
    <name>O86720_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6538</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35230">
        <property type="entry name" value="T35230"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030995.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6538"/>
    <dbReference type="GeneID" id="1101977"/>
    <dbReference type="KEGG" id="sco:SCO6538"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6641"/>
    <dbReference type="eggNOG" id="ENOG50331CU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134369_3_0_11"/>
    <dbReference type="InParanoid" id="O86720"/>
    <dbReference type="OMA" id="MWADAAS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="14341" checksum="E656F3301DE00DE6" modified="1998-11-01" version="1">MSTHQLAALARTAEPRLMLRRFLALDAAVTGANALAYLALSGPLGRCLGAGPGLLLALGAFLAVYAGCVGLLAARSRPPALAVRAVVEANLAWAAVSFAALALWLTPTTAGAVWTVLQALVVAAFALLQHGALRQDQGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O86732</accession>
    <name>O86732_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35242">
        <property type="entry name" value="T35242"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630631.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6550"/>
    <dbReference type="GeneID" id="1101989"/>
    <dbReference type="KEGG" id="sco:SCO6550"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6654"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="InParanoid" id="O86732"/>
    <dbReference type="OMA" id="TMGMYSP"/>
    <dbReference type="PhylomeDB" id="O86732"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="23898" checksum="3E45F476FAC0F6E2" modified="1998-11-01" version="1">MTDAPVTLITGGGSGIGAAVARRLLDAGQRVAVTGRGEERLRAFSAELGDPAGLLTLRGSAAEHTQVVSAVEATLKEFGRIDTVVANAGFATHDSVAEGDPAGWTEMVLTNVLGPALLIRASIDALKATRGRIVLVGSVAGFVNTPGNIYGATKWAVTGLAENTRREVTQWGVGVTLIAPGRVETPFWDGTGGLPPGELLTAGQIADSVVWAMTQPAGVDVNTVVVRPLGQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O86749</accession>
    <name>O86749_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5650</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35448">
        <property type="entry name" value="T35448"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629780.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030364.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5650"/>
    <dbReference type="GeneID" id="1101089"/>
    <dbReference type="KEGG" id="sco:SCO5650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5733"/>
    <dbReference type="eggNOG" id="ENOG502ZN5A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199278_0_0_11"/>
    <dbReference type="OMA" id="NAEYRIH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174891" evidence="3">
        <location>
            <begin position="39"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="23604" checksum="1D1E796C1877722C" modified="1998-11-01" version="1">MAVLSIISRTASRRGVRALGVVAASAALALSASGNALACNISEFSAEAKCDGDNGVITVTDVDPAGIPATVTVYLKDGDKQVGQQTVKGSKDGTTVSFPVDWQPNTTYRVHVKADRYVDEDIQPDVTTPSTPCKTEDTPTPTPSESSSTPSDETESPAPEPSTSAPAPSQSESTAPAAVPNDNAPSPAAGDSNLAETGANSNTGMIAGIAAALVVVGGGAVFFGLRRRGANSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>O86767</accession>
    <name>O86767_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35466">
        <property type="entry name" value="T35466"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629764.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030350.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000044.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101072"/>
    <dbReference type="KEGG" id="sco:SCO5632"/>
    <dbReference type="eggNOG" id="ENOG503142W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2588102_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="80" mass="8201" checksum="7B17BAF8E4643066" modified="1998-11-01" version="1">MRPSTPDNGGNAAPSGDEEPTGAAYIKITTVPNGPSVMASVPEKEATRMLETGEFAVGIGGTVIGPYAMARHCPADHVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O88053</accession>
    <name>O88053_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1593</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36828">
        <property type="entry name" value="T36828"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625869.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027869.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1593"/>
    <dbReference type="GeneID" id="1097024"/>
    <dbReference type="KEGG" id="sco:SCO1593"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1605"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_4_1_11"/>
    <dbReference type="OMA" id="AGICAYD"/>
    <dbReference type="PhylomeDB" id="O88053"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="446" mass="47750" checksum="1381EBFB8AE67836" modified="1998-11-01" version="1">MQPNTLLDAILDEAGISHAGLAAHVNQAGRARGLALRYEHTAVARWLKGQRPRGQVPDLICEVLASRLHRPVTLDDIGLGVPGEPAAPHTGSLSGFVERATALWRSDQQQRPHILGAPALTGTPAVMPVWEWENPPEDTDVSRGGRHRVTAADLETVRCARTHYEQMYRKAGGIATRARIVGFLNSEAAPLLRGSYTDAVGRQLHRATGGLVAVAGICAYDSDAHGLAQRYFHQALRLAKASGDRGLGAYVIALLVNQALFTREYRQAVAFAEAALRAAGRHITPALASDLYAMQAKAYAHLGDGSGALACIRRAEQAAERIRRGYEPDETGYVQPGLVNVQVAEALLSLGELAAAGEHAAAAVDTPAHDRGRVHRLAMLSTIELRQGHADKAVATAVRMAEQARGMESHRLRDRLRAVREHLVTSGCAGTAEAAELIDGALRVPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>P0A4T8</accession>
    <accession>P32184</accession>
    <name>TIPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>HTH-type transcriptional activator TipA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tipA</name>
        <name type="ordered locus">SCO3413</name>
        <name type="ORF">SCE9.20</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional activator. Is activated when bound to the antibiotic thiostrepton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36339">
        <property type="entry name" value="T36339"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975420.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A4T8"/>
    <dbReference type="BMRB" id="P0A4T8"/>
    <dbReference type="SMR" id="P0A4T8"/>
    <dbReference type="GeneID" id="1098850"/>
    <dbReference type="KEGG" id="sco:SCO3413"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3476"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_0_6_11"/>
    <dbReference type="InParanoid" id="P0A4T8"/>
    <dbReference type="OMA" id="HAGHRRY"/>
    <dbReference type="PhylomeDB" id="P0A4T8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000098157" description="HTH-type transcriptional activator TipA">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="253" mass="28711" checksum="0B32F6191BF2B779" modified="2005-03-15" version="1">MSYSVGQVAGFAGVTVRTLHHYDDIGLLVPSERSHAGHRRYSDADLDRLQQILFYRELGFPLDEVAALLDDPAADPRAHLRRQHELLSARIGKLQKMAAAVEQAMEARSMGINLTPEEKFEVFGDFDPDQYEEEVRERWGNTDAYRQSKEKTASYTKEDWQRIQDEADELTRRFVALMDAGEPADSEGAMDAAEDHRQGIARNHYDCGYEMHTCLGEMYVSDERFTRNIDAAKPGLAAYMRDAILANAVRHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKG4</accession>
    <name>Q7AKG4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">SCO5240</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629386.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973730.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5240"/>
    <dbReference type="GeneID" id="1100681"/>
    <dbReference type="KEGG" id="sco:SCO5240"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5324"/>
    <dbReference type="eggNOG" id="ENOG5032RSG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
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        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC05979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="85" mass="9700" checksum="D8758AC631D8A017" modified="2012-05-16" version="1">MDWRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQCLQWALESGQDSGVWGGLSEDERRAMKRRAARNRARQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJW2</accession>
    <name>Q8CJW2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO3580</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
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        <property type="entry name" value="T36565"/>
    </dbReference>
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        <property type="entry name" value="T36689"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029098.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CJW2"/>
    <dbReference type="STRING" id="100226.SCO3580"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
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    <dbReference type="GeneID" id="1099016"/>
    <dbReference type="KEGG" id="sco:SCO3580"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3636"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_6_11"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:carboxypeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="77"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="364"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="677"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAD55325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="756" mass="80141" checksum="1DB6C5A76B7D66FA" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX3</accession>
    <name>Q8CJX3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36245">
        <property type="entry name" value="T36245"/>
    </dbReference>
    <dbReference type="PIR" id="T36319">
        <property type="entry name" value="T36319"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1098661"/>
    <dbReference type="KEGG" id="sco:SCO3227"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3290"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="InParanoid" id="Q8CJX3"/>
    <dbReference type="OMA" id="YGRTKGI"/>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transaminase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
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        <property type="project" value="UniProt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="444" mass="47849" checksum="F2D973588F01E6BF" modified="2003-03-01" version="1">MTTTTPARTDRDGVLARTALHPSLSAPLLDTMNFLNEVTLRYPQAISFAPGRPYEGDFDVARVPGYIETYLDHLRGRGHSEERVRTALYQYGETAGQIRDIVARMLEVDEDLTVDPASVVVTVGCQEAVLLTLRALFTGPEDVLLVDSPAYVGITGAAGLLDIPVVPVPGTPDGPSPEGLERTVREIEASGRRARCLYVVPDCSNPTGVSLRREARTALLDAAARLDLLLLEDNPYGVFSRVRRPTLKSLDTERRVVYLGSFAKTAFPGARVGFVVADQLVAGADGRPPGLLAHELAKVKSMVTVNTPTLSQAAVAGLLLQNGGGLRAANEASARHYQSTMRCLRDTLAAELPPGAPESGGVRWNDPDGGFFLTLDVPFEADEAALDVSAEKYGVIWTPMRHFHLDDAGDRQIRLSCSYLTTDRAAEGATRLARFVKDRAASNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJZ8</accession>
    <name>Q8CJZ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracenomycin C efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2373</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAD55303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733568.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2373"/>
    <dbReference type="GeneID" id="1097807"/>
    <dbReference type="KEGG" id="sco:SCO2373"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2413"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q8CJZ8"/>
    <dbReference type="OMA" id="IWGMVIG"/>
    <dbReference type="PhylomeDB" id="Q8CJZ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD55303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="536" mass="54594" checksum="9ACF3093A8D11E6E" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J66</accession>
    <name>Q93J66_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0977</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625273.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027486.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0977"/>
    <dbReference type="GeneID" id="1096400"/>
    <dbReference type="KEGG" id="sco:SCO0977"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.974"/>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_0_0_11"/>
    <dbReference type="InParanoid" id="Q93J66"/>
    <dbReference type="OMA" id="PLCPYVV"/>
    <dbReference type="PhylomeDB" id="Q93J66"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="116" mass="12529" checksum="0981B079398A5113" modified="2001-12-01" version="1">MAVSDIEIRDDRAAGRLEGVTAGEVVGRIEYFVLEAPARALVPVHTIVEPAHEGQGIAGSLARELYGIARREGVTVAPLCPYVVKWAERHPDEAPAADPELLRAAKEWLVAHPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J93</accession>
    <name>Q93J93_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane binding-protein-dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7504</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631550.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7504"/>
    <dbReference type="TCDB" id="3.A.1.1.36">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1102942"/>
    <dbReference type="KEGG" id="sco:SCO7504"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7617"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="InParanoid" id="Q93J93"/>
    <dbReference type="OMA" id="LWMSFTD"/>
    <dbReference type="PhylomeDB" id="Q93J93"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC44682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34590" checksum="56F30CEF91EE3114" modified="2001-12-01" version="1">MTDVTTTAPLGAEERTAPPAAAPGGRRSALGRIRTGNGLVFVLPFLLVFGLFMVWPIVQGLWMSLTDSSLALRDPGFVGFDNYTEAFGDPDVWSSLGNTVFFTGVSSVPLVLVALAMALLVHSGLAGQWAWRLSFFAPYLLPVTVVTMIWTWLYQPELGMANQLLDALGMAPVGWLSDESVAMWSVAALTVWWTVGFNFLLYLAALQSLPTTFDEAAALDGAGAWRRLWSITLPQLRRTTGLVAMLQVLASLKVFDQIYILTKGGPNGSTRPVLEYVYDVGFTGYRLGYASAVSYLFFALIVLVSLVQLRLFRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA4</accession>
    <name>Q93JA4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7492</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631539.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031701.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7492"/>
    <dbReference type="GeneID" id="1102930"/>
    <dbReference type="KEGG" id="sco:SCO7492"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7604"/>
    <dbReference type="eggNOG" id="COG1626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015270_1_0_11"/>
    <dbReference type="InParanoid" id="Q93JA4"/>
    <dbReference type="OMA" id="RIPHIVF"/>
    <dbReference type="PhylomeDB" id="Q93JA4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="454" mass="50430" checksum="BD7D56DF3E0F937B" modified="2001-12-01" version="1">MNSPLDLLDRPAPTAPADLTLRRGAARVLIDNWTGASTVPSRTLYPHQWSWDSAFVAIGLRHLSVRRAQRELESLLAAQWADGRVPHIVFNPALPHDAYFPSPDFWRSSTEGRTAGAPSSVETSGIVQPPVHALAAWLVHRADPAESRRRGFLARVRPRLAAWHDYLLGRRDLGGGGLAAVVHPWEPGMDNSPSWDRALKRVEPSPPDTFRRADLDHGHPADRPTDLDYGRYVRLATEYREAGYDDRVVRHRFAVEDPAFNALLIVSELALAAMARELGLPGQRHTERAAGLTRALVDRLWDEQAGLFRVRDLHTGAPVDERTVSGLIPLLVPRLPEHIVRRLHTTLTGPRFSAPATHLVPSYDLTGHAFDPTRYWRGPAWFNTAWLIERGLRTHGFQTDAERLRTGFLTEAGRSGFAEYVDPATGAACGTRHFSWTAALTLDLLSTDPKEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA5</accession>
    <name>Q93JA5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7491</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631538.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031700.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7491"/>
    <dbReference type="GeneID" id="1102929"/>
    <dbReference type="KEGG" id="sco:SCO7491"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7603"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_8_1_11"/>
    <dbReference type="InParanoid" id="Q93JA5"/>
    <dbReference type="OMA" id="NRYEDHM"/>
    <dbReference type="PhylomeDB" id="Q93JA5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="29343" checksum="C0D1183D19C228A0" modified="2001-12-01" version="1">MLKTAVQEQLLPGETLQAKWDFAQQAGYDAIELRGKGDFHFASRREELRQARRDGVVMPTVCVDMLHFLGAFDEDLRRDAVAQMKSQLTVIAEIGGVGAQTPASYGMFSRRLPPFEPPRTKEEDREVLLAGLTELGEHARREGVTLFLEPLNRYEDHMVNRLDQAADLIRAVGLDSVRIGIDSYHMNIEETDPAAAVVAHADVIGHAQVSDSNRFQPGAGHLDWPAWLGALHTVGYDGHLALESRLTGDPVQAVRSVPAFLKRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QP4</accession>
    <name>Q99QP4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.29</name>
        <name evidence="2" type="ordered locus">SCP1.325c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
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            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
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            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
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            <strain evidence="2">A3</strain>
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        </source>
    </reference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36551.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CAC36850.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    <sequence length="152" mass="16226" checksum="0F5415D8DB838414" modified="2001-06-01" version="1">MGLLFAAMDDELTNDDHLRALAALEAVVQNDDGALQALVGGTRERPLAALLAAYGQHTLHRVLLAAFGIEATMTYDETGQRVAELNGDPMARIVFLLADSLHHQAILAGDDLVTAKRIGGSVLLAIHAFTDADNQDALALLRALRNEALQGY</sequence>
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    <accession>Q99QQ4</accession>
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
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            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
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    <reference evidence="6" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="6">SCP1</plasmid>
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    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
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                <person name="Chater K.F."/>
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            <dbReference type="PubMed" id="19054329"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
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        <property type="protein sequence ID" value="CAC36861.1"/>
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        <location>
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        </location>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="783"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51898"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC36540.1"/>
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    </evidence>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
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                <person name="Harper D."/>
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                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
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                <person name="Goble A."/>
                <person name="Hidalgo J."/>
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                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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                <person name="Rutherford K."/>
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        <property type="entry name" value="Hint_dom_N"/>
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    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03752">
        <property type="entry name" value="ALF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1336" mass="138929" checksum="853BC6DF36A86939" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADB3</accession>
    <name>Q9ADB3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO5355</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629495.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973642.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5355"/>
    <dbReference type="GeneID" id="1100795"/>
    <dbReference type="KEGG" id="sco:SCO5355"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5435"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADB3"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="PhylomeDB" id="Q9ADB3"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="352" mass="36771" checksum="DAA4B63AB27737F3" modified="2001-06-01" version="1">MTHQWRGIIEEYRDRLPVSDSTPVVTLREGGTPLVPAQVLSERTGCEVHLKVEGANPTGSFKDRGMTMAISKAKEEGAQAVICASTGNTSASAAAYGVRAGMVSAVLVPQGKIALGKMGQALVHGAKILQVDGNFDDCLTLARALSDNYPVALVNSVNPVRIEGQKTAAFEIVDMLGDAPDIHVLPVGNAGNITAYWKGYQEYAADGVSTKKPRMWGFQASGSAPIVRGEVVKDPSTIATAIRIGNPASWDFALAARDESGGAIDEVTDREILRAYRLLASQEGVFVEPASAASVAGLLKAAEQGKVDPGQRIVCTVTGNGLKDPDWAVAGAPQPVTVPVDAATAAERLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADC7</accession>
    <name>Q9ADC7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629480.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030189.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5340"/>
    <dbReference type="GeneID" id="1100780"/>
    <dbReference type="KEGG" id="sco:SCO5340"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5422"/>
    <dbReference type="eggNOG" id="ENOG5031TZ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208644_0_0_11"/>
    <dbReference type="OMA" id="PECQDGQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="65" mass="7050" checksum="7F111F0574D82657" modified="2001-06-01" version="1">MATAKKPTTRRKITPPAPEPALCPDCDGKGETRETVRVGARKMRVTDDHQTALCLTCWGTGHATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADH4</accession>
    <name>Q9ADH4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative antibiotic resistance rRNA adenine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6089</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630197.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030647.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6089"/>
    <dbReference type="GeneID" id="1101530"/>
    <dbReference type="KEGG" id="sco:SCO6089"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6192"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_3_1_11"/>
    <dbReference type="InParanoid" id="Q9ADH4"/>
    <dbReference type="OMA" id="RHEHGQN"/>
    <dbReference type="PhylomeDB" id="Q9ADH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="5">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28877" checksum="9C95D189E8A86361" modified="2001-06-01" version="1">MARPTQRARTLSQNFLADRATAERVAHLAVPDRGRRPLLLEVGAGNGALTEPLARRSRELHAYEIDPRLVPGLRARFARSPHVHVVAGDFLTARPPRTPFAVAGNVPFSRTADIVDWCLTAPGLTDATLLTQLEYARKRTGDYGRWTLLTVLTWPRHEWRLVGRVGRSRFCPAPRVDAGILRIERRPTALLTGAAARRDWADLVELGFSGVGGSLHASLRRAHSRRRVDAAFRAARLDPGVLVGEVAPDRWLRLHEELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADM6</accession>
    <name>Q9ADM6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative marR regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628214.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029397.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4032"/>
    <dbReference type="GeneID" id="1099468"/>
    <dbReference type="KEGG" id="sco:SCO4032"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4095"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="InParanoid" id="Q9ADM6"/>
    <dbReference type="OMA" id="RHGDMRM"/>
    <dbReference type="PhylomeDB" id="Q9ADM6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="18359" checksum="F0E6DF682AFDE445" modified="2001-06-01" version="1">MAEKAQYEELIRQFSAFGAVKREMGRLLPSDCPGGSVAVLTLLGRHGDMRMSKLAELLAVDMSVTSRHVAHGAERGWIERFPDPADKRSRILRLTSAGQDQLDEIAERTTQLLSHRLSDWSDDEVGQLSRLMARLRASFDDCRAPAARPPALSGDEQSTRTPAITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK37</accession>
    <name>Q9AK37_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4889</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629042.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974083.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4889"/>
    <dbReference type="GeneID" id="1100330"/>
    <dbReference type="KEGG" id="sco:SCO4889"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4969"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AK37"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="PhylomeDB" id="Q9AK37"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009972">
        <property type="term" value="P:cytidine deamination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="13694" checksum="37FFBDA9BD57543C" modified="2001-06-01" version="1">MTGADWEELRTAARDAMSRAYAPYSGYAVGAAALVDDGRTVTGCNVENASYGIGLCAECGLVSQLQVTGGGRLTHFVCVDGAGEVLVPCGRCRQLLYEFGGPELLLETPEGILPLSRMLPQAFGPDHLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWQ7</accession>
    <name>Q9EWQ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7670</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031817.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7670"/>
    <dbReference type="GeneID" id="1103108"/>
    <dbReference type="KEGG" id="sco:SCO7670"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7789"/>
    <dbReference type="eggNOG" id="COG1755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102515_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWQ7"/>
    <dbReference type="OMA" id="LHHPNYV"/>
    <dbReference type="PhylomeDB" id="Q9EWQ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC17487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18521" checksum="55776BF49D854595" modified="2001-03-01" version="1">MPWYALLVLAVAVERVAELVVARRNAAWTLARAGVEHGRGHYPVMVALHTGLLACCLLEPLLADCPFLPALGWPMLALALSAQALRWWCIATLGPYWNTRVIVVPGTRPVGAGPYRFLRHPNYLAVVVEVAALPLVHSAWLTAAVFTAANAMLLTVRLRCENTALAQLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWR5</accession>
    <name>Q9EWR5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0787</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625089.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027355.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0787"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="GeneID" id="1096210"/>
    <dbReference type="KEGG" id="sco:SCO0787"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.779"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_4_1_11"/>
    <dbReference type="InParanoid" id="Q9EWR5"/>
    <dbReference type="OMA" id="WMLGTPV"/>
    <dbReference type="PhylomeDB" id="Q9EWR5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176642" evidence="1">
        <location>
            <begin position="32"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="286"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="422" mass="44143" checksum="7105047BE26F3020" modified="2001-03-01" version="1">MARPRLLRRCLLAAALSAGLAASLVTGPAQADPETSRAAGSVGSASSSAAAAVAFSDTFDGPAGAAVDSSKWQIETGDNVNNHERQYYTSGNKNAALDGQGHLVVTARKENPANYQCWYGTCQYTSARLNTSGKFTAQYGHVEARMKVPRGQGMWPAFWMLGTPVNWPDSGEIDIMENVGFEPSTVHGTIHGPGYSGSGGIGAGYTLPGGQAFADAFHTFAVDWAPDSITWSVDGTVYQRRTPADLGGKQWVFNRPYFLILNLAVGGYWPGDPDGSTVFPQTLVVDHVSVTTGDSPTGGAIRGLAGKCVDVAAANTANGTPVQLYDCNGTAAQRWTVGSDGTIRALGKCLDVNAGGTADGTVVQLWDCNGSAAQRWVVTAARDIVNPQADKCLDVTGNNAANGTRLQIWTCTGGANQKWTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWY8</accession>
    <name>Q9EWY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1138</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625431.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027602.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1138"/>
    <dbReference type="GeneID" id="1096561"/>
    <dbReference type="KEGG" id="sco:SCO1138"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1135"/>
    <dbReference type="eggNOG" id="COG3181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045683_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EWY8"/>
    <dbReference type="OMA" id="NYIPFDG"/>
    <dbReference type="PhylomeDB" id="Q9EWY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325011" evidence="2">
        <location>
            <begin position="31"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC13090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="34950" checksum="B585ECFF20FEA8BF" modified="2001-03-01" version="1">MVSYVRLRTPLALLGAAVLVLAGPPLLSSGDDSVSGTQIPGLRFMVPNTPGGGYDITARTAAKNAEDAGITHNIEVFNLPGAGGTVGLSRLVSEHGNGKLAMSMGLGVVGAVRSNHAPKTLADTTPIARLTEEQDVVVVGKDSPYKTIDELIDAWKQDPGKIPVGGGSSPGGPDHLAPMLMAQAAGIQPKSVNYIPFDGGGELLASILGNKVGFGVSGVGEYLDQIKAGELRVLAVTGPERVDDLEDAPTLKESGYDVNFTNWRGIVAPPGLSEAQRNKLTRLFEELHDSPEWKKSMDQNGWDDAFLTGEEFGDFLDAQDERVVSVLKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX02</accession>
    <name>Q9EX02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1124</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625417.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027590.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1124"/>
    <dbReference type="GeneID" id="1096547"/>
    <dbReference type="KEGG" id="sco:SCO1124"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1121"/>
    <dbReference type="eggNOG" id="ENOG5031MWT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111071_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EX02"/>
    <dbReference type="OMA" id="DWLQYAW"/>
    <dbReference type="PhylomeDB" id="Q9EX02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010773">
        <property type="entry name" value="Mycophage_PG1_Gp7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07098">
        <property type="entry name" value="DUF1360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="17320" checksum="0F84FD8682DE27A1" modified="2001-03-01" version="1">MTDVEQRYADGEETSLLGYAALATTFAAGAGAFTVTAWRRGVRLPDSVPAWDVVLLGTATFKASRLLTKDKVTSFLRAPFTRRQREGNANEVMDAGRGTGLRRAVGDLISCPFCTSAWVAGGLVGTYAVAPRAGRLVCAGLSAVVVSDWLQYAWSLTAQKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Q6</accession>
    <name>Q9F2Q6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3093</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627311.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975718.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3093"/>
    <dbReference type="GeneID" id="1098527"/>
    <dbReference type="KEGG" id="sco:SCO3093"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3155"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_2_11"/>
    <dbReference type="InParanoid" id="Q9F2Q6"/>
    <dbReference type="OMA" id="IGCVRMT"/>
    <dbReference type="PhylomeDB" id="Q9F2Q6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="33416" checksum="55A06F5DC40AB39C" modified="2001-03-01" version="1">MTRVAAVDCGTNSIRLLVADADPATGELTDLDRRMTIVRLGQGVDRTGRLAPEALERTFAACREYAEVVKAHGAERLRFVATSASRDAENRDDFVRGVLDILGVEPEVISGDQEAEFSFTGATKELTGRADLDKPYLVVDIGGGSTEFVVGEDHVRAARSVDVGCVRMTERHLVRDGAVTDPPTAEQVAAMRADIEAALDLAGRTVPLGEARTLVGLAGSVTTVSAIAQELPEYDSAAIHHSRVSRDRVREITDWLLASTHAERAAVASMHPGRVDVIAAGSLVLLAIMERTGAEEVVVSEHDILDGIAWSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Y7</accession>
    <name>Q9F2Y7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4360</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029603.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4360"/>
    <dbReference type="TCDB" id="3.A.1.105.13">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099800"/>
    <dbReference type="KEGG" id="sco:SCO4360"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4428"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F2Y7"/>
    <dbReference type="OMA" id="YKDFLMP"/>
    <dbReference type="PhylomeDB" id="Q9F2Y7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="32"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC08316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="30188" checksum="408F7AF8A7B30914" modified="2001-03-01" version="1">MSALGVDSAPGPAPVPSERGRLYWLLADCGNIVRRGLTHYQRQPVNIAWQLGFPILSVLLYGYVFGSAMTVPGGGDYKDFLMPGMFVMTMAFGFINTATVVVYDSTKGVIDRFRSMPMASSAVVAGRGVTDLLVACAELAIMMLTAMAMGWRPEGGWGFVAAFGLLLWLRFALIWIGVWLGLLVPNPEAAGGLFAVAFPLTMISSIFVAPQLMPDWLGWVAAWNPISSTAAAARDLFGTPVGGGDSWVEQHALLMAGVWPVVLTAIFLPLAVRRFQRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F303</accession>
    <name>Q9F303_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4113</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC08409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628292.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029442.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4113"/>
    <dbReference type="GeneID" id="1099550"/>
    <dbReference type="KEGG" id="sco:SCO4113"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4173"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_0_1_11"/>
    <dbReference type="InParanoid" id="Q9F303"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="PhylomeDB" id="Q9F303"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="426" mass="45671" checksum="F6E1BD92C9112B73" modified="2001-03-01" version="1">MGREMEEVRAGLVRSTVYDCDVLVIGGGIVGLSTAYAITRAAPGTRVTVLEKEPGPARHQTGRNSGVIHSGVYYRPGSLKARYAVRGAAEMVKFCAEYGIDHAVTGKLIVATDRAELPRLHALVQRGRENGIPVRELSGAQIQEYEPEVRGLAAIHVGTTGICDYVAVARQLARASGAEIRYGAEVHRVDRRPGLGVAVRTRTGDVLRARVLVNCGGLHCDRIARLTGDDTGMRIVPFRGEYYELARPELVRGLVYPVPDPAFPFLGVHLTRGIDGGVHVGPNAVPALAREGYGWGVVRPRELGATLAWPGSWRIARRHWRYGAGELRRSLSRSAFTTAVRRLLPAVTEDDLVAAPAGVRAQAVLADGTLVDDFLIKEGAHAVHVLNAPSPAATASLPIGREVARRALAMLADQAPPGRPAPRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F333</accession>
    <name>Q9F333_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5137</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629286.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973840.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5137"/>
    <dbReference type="GeneID" id="1100578"/>
    <dbReference type="KEGG" id="sco:SCO5137"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5220"/>
    <dbReference type="eggNOG" id="ENOG50346PN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132123_1_0_11"/>
    <dbReference type="OMA" id="EDTLPTK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176670" evidence="2">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="143" mass="12979" checksum="8D162C51C215E692" modified="2001-03-01" version="1">MSLPLTRRIARAALLVAAGAAAGVGAAGSASAAPELPATPNLGGLTALDGANVGNTAASAAESATETAGDTGGKAVKKAVPTAGKTGGSVVKKATPAAQNAAGDAAGSAGDIVGDTAATATKGGLPTDALGKGGLPVQGLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F345</accession>
    <name>Q9F345_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629274.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973852.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5125"/>
    <dbReference type="GeneID" id="1100566"/>
    <dbReference type="KEGG" id="sco:SCO5125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5208"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_0_11"/>
    <dbReference type="OMA" id="PDDDWAL"/>
    <dbReference type="PhylomeDB" id="Q9F345"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="32167" checksum="9951067A57D99AE3" modified="2001-03-01" version="1">MSVDAGTDQVDEPGWEVDPDDDWALAVIATVGRQLRLRREAAGMRAPDFAVAIGYGEDLVYKVEGGRRIPRPEYLDRADEVLTAGGLVAAMKEDVKKVRYPKKVRDLAQMEARAVELQLYDPVNVHGLLQTPDYARALFRMRRPRYAEDEIERGVAARTARKAVFERDPAPELGFVQDEWTLRRRLGGTDVVRRQLEHLLMLGRLPNVEIQVMPMDREEHAGVDGAIEVLKFEDGTAVGRSPGVANGRPVTDLRQVRILELRYGIIRAQALTPCESAAFIEQLLGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3A9</accession>
    <name>Q9F3A9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oligopeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7566</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC16446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1103004"/>
    <dbReference type="KEGG" id="sco:SCO7566"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7680"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="Q9F3A9"/>
    <dbReference type="PhylomeDB" id="Q9F3A9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC16446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="288" mass="31236" checksum="30C723152CD7CC4A" modified="2001-03-01" version="1">MTNDRPTTGPGRPTGHAPRRPADRQPLLEIDGLSVDFHLAGSVVHAVRDVSLHVRAGETLAVVGESGSGKSATALSVLRLNPSPPCVYASGEIRFDGRDLLRLSEKELGRVRGRDIAMVFQDPMTCLDPLQRVGAQVAEVLRHHTGMSRAEAAKAALAALDEVGIPDPALRYRQYPHELSGGLRQRVMIATALVARPRVLIADEPTTALDVTVQRQILDLLVTLQHKHDMGVVLITHDLAVVAETADRVVVMHRGKVVETGDVLDVFDRPADDYTRRLLAATPRLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3G2</accession>
    <name>Q9F3G2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4538</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628701.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029716.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4538"/>
    <dbReference type="GeneID" id="1099978"/>
    <dbReference type="KEGG" id="sco:SCO4538"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4611"/>
    <dbReference type="eggNOG" id="ENOG5033AJ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172312_0_0_11"/>
    <dbReference type="OMA" id="EDFESHW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="12537" checksum="0F79AB604C1F6B61" modified="2001-03-01" version="1">MGKSDLALPLTELEDYGRRLRSLKTRLNHTKKLFESYKDDIGDGSVNDALDDFESNWEDGREDITQQLDALASMSDAVVREFKKLDDELTKQVNDAVKTEDKRGGKGGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBJ6</accession>
    <name>Q9FBJ6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5162</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629310.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973815.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5162"/>
    <dbReference type="GeneID" id="1100603"/>
    <dbReference type="KEGG" id="sco:SCO5162"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5245"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBJ6"/>
    <dbReference type="OMA" id="LFVIMDP"/>
    <dbReference type="PhylomeDB" id="Q9FBJ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00427">
        <property type="entry name" value="TIGR00427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC01363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21123" checksum="813D3B454FCC5B05" modified="2001-03-01" version="1">MFDVAVFGSLFLTLFVIMDPPGITPIFLALTSGRPGKVQKRMALQAVCVAGGVITVFGLLGHQILDYLHVSVPALMIAGGLLLLLIALDLLTGKTDEPKQTKDVNVALVPLGMPLLAGPGAIVSVILAVQKADSVTTQVSVWAAILAIHVVLWLVMRYSLLIIRVIKDGGVVLVTRLAGMMLSAIAVQQIINGVTQVIQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBZ8</accession>
    <name>Q9FBZ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative branched amino acid transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO7184</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631242.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7184"/>
    <dbReference type="GeneID" id="1102622"/>
    <dbReference type="KEGG" id="sco:SCO7184"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7283"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_2_2_11"/>
    <dbReference type="InParanoid" id="Q9FBZ8"/>
    <dbReference type="PhylomeDB" id="Q9FBZ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="349" mass="35644" checksum="CA0D80FB392FC2DE" modified="2001-03-01" version="1">MSHRARALVGSRAAGYAVFVVLLLAVPAVFTRVPFYTMSVAVLMCLQATAALGLVPLVGRAGQISLGQAAFFAVGGYTSAILTGRWHVNALLALTAGVALAMAVAYVVGLFIFRAQGQYLALATLSFGLVVSSLANQLPLTGASNGLAGIPSLAPFGVELDTDLSVYYLVAGVLLVAVLSVDALLRSPAGDALSALGDSPVATEAAGVSAAALRRGALALAAGLASIAGSLYAHWSSFMDSGQAGLLNSVQLLVIASVGGLRTPWGAPLGALVIVTFSEASKDLIPKVFPSATGNFDIIVYGIALIAVLLFLPRGVGGVTAVRRERSVRKRQDGPAPATTARTQERETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC08</accession>
    <name>Q9FC08_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631232.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031479.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102612"/>
    <dbReference type="KEGG" id="sco:SCO7174"/>
    <dbReference type="HOGENOM" id="CLU_2453236_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325430" evidence="2">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="89" mass="9464" checksum="A03AC7F351AD6BAC" modified="2001-03-01" version="1">MASAAATAGTAGALPVMSGQAHADTRGLPSLWDVDRSVVNPENAYTVTVDQVRAEVAQLMGATEEEFTRPRSAGRLRARPAPRRACRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC15</accession>
    <name>Q9FC15_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7069</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631131.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031414.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7069"/>
    <dbReference type="GeneID" id="1102507"/>
    <dbReference type="KEGG" id="sco:SCO7069"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7174"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844457_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC15"/>
    <dbReference type="OMA" id="TSVHVMW"/>
    <dbReference type="PhylomeDB" id="Q9FC15"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="34508" checksum="CF8290D22BEC041C" modified="2001-03-01" version="1">MREVPVPSLPRRCALLCGTLLLLTSCGWGPGGDGEGGGLPAVPTGVTAEAGSATTVHVMWNAVDDVRTYEVYRGGTLVKEVPKAERMVDVTRLRPSTAYVFTVRARDAEGRLGPPSREVRATTPAAVADDLAPTRPGDVRGRAAGSRAVQLTWSAAKDDRGVVSYDVYQGDAKVHSVGGNQTAAVVTGLRAGTRYAFTVRARDAADNVSPAGAAVRLTTPGTDDGHATAPTDLRAASHRADGAYYLDLSWVPPRTETPVTEYRIHLDGRAATSLVYGADAPRDRAEYSFYAGREAGVVHRVRIRARLADGTWGGLSAERKVTLGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC97</accession>
    <name>Q9FC97_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1216</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625505.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977615.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1216"/>
    <dbReference type="GeneID" id="1096639"/>
    <dbReference type="KEGG" id="sco:SCO1216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1215"/>
    <dbReference type="eggNOG" id="ENOG502ZTPB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201968_0_0_11"/>
    <dbReference type="OMA" id="SSGWLWF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="6782" checksum="6D5737BEB06A4462" modified="2001-03-01" version="1">MEGNGHEEGVAMPGSTDSSTKTMGALTIGGLVAVTAYTVALGSNGWLWFGWVVLGLITLGLVATRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCA9</accession>
    <name>Q9FCA9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1204</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625493.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027651.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1204"/>
    <dbReference type="GeneID" id="1096627"/>
    <dbReference type="KEGG" id="sco:SCO1204"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1203"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_11"/>
    <dbReference type="InParanoid" id="Q9FCA9"/>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="PhylomeDB" id="Q9FCA9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="461" mass="50021" checksum="666610EFDBD18204" modified="2001-03-01" version="1">MPIATVNPANGETLRTYEAMGEEEIERRIELAEATFRTYRTTGFYERAGLMRRAADLLEADQKEIGKVITTEMGKPVKQARAEAAKCAKAMRWYADHAAELLADEEPAEADVKDSGASRALVRYRPLGPVLAVMPWNFPLWQVIRFAAPALMAGNVGLLKHASNVPQTALYLEDLFHRAGFPEGCFQTLLIGSAQVDDVLRDERVRAATLTGSEPAGRAVAATAGEMIKKTVLELGGSDPFVVMPSADVERAAEVAVTARTQNAGQSCIAAKRFIVHTDVYDAFAQRFTEGMRALKVGDPMDEETEVGPLSSEQGLNDLVELVDDAVRGGASVLCGGERPDGPGWYYPPTVLAGVTRELRIHREEAFGPVATLYRAADLDEAVLIANDTDFGLSSNVWTRDDADVDRFVRDLEAGGVYVNGMTASHPAFPFGGVKRSGYGRELSGHGIREFCNITTVWHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCC8</accession>
    <name>Q9FCC8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625527.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977592.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1239"/>
    <dbReference type="GeneID" id="1096662"/>
    <dbReference type="KEGG" id="sco:SCO1239"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1238"/>
    <dbReference type="eggNOG" id="ENOG50343I6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2275763_0_0_11"/>
    <dbReference type="OMA" id="MHRRGET"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="102" mass="11023" checksum="698FCDD6FC9C75A9" modified="2001-03-01" version="1">MLPPELPPLPALTRAEAEVVDRYLDVVDLLGRINPGRDGDTYRGLRAAQALVGKAAALRDALTLMHHRGETEVHAATLARALRVLDGERRTARVGLPPPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH3</accession>
    <name>Q9FCH3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative organophosphate acid anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4196</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628371.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029495.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4196"/>
    <dbReference type="GeneID" id="1099636"/>
    <dbReference type="KEGG" id="sco:SCO4196"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4260"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_6_1_11"/>
    <dbReference type="InParanoid" id="Q9FCH3"/>
    <dbReference type="OMA" id="VTTVCDM"/>
    <dbReference type="PhylomeDB" id="Q9FCH3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="50"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="42777" checksum="EF0CDDEB1B631AC6" modified="2001-03-01" version="1">MALTAITNAQVFDGEKTVGVRTVVIDGTRIARVGGEVPRDCEVVDGSGATLLPGLIDAHVHSAPGSLALALRFGVTTELEMQGMNTRENRGSIADDDTLADVRSSGFAITPPGGHPSELMPEGFRPKWDLPPVMPLMPFSTTPEEAAAYVPQLLARGSDFIKFMIDDGTVEGHPGLPSLDRATLNAGVAEARKYGALTVAHALTVEATRMAAEAGVDGVTHVFMDQPHTAEIIDLIRDAGMFVIPCITLNASMMGVTGSELADDPRVAARLDDSWDRTLRSSYDRYPQGSLEDVCATVRALDAAGVDVLAGTDVSMPETFFGGLAHGASLHHELQYLVAAGLTPSRALRAATATTARRFRLSDRGRVAEGLRADLLLVDGDPTGDIGDTLNTRAVWRRGTRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL9</accession>
    <name>Q9FCL9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7795</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031919.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7795"/>
    <dbReference type="GeneID" id="1103233"/>
    <dbReference type="KEGG" id="sco:SCO7795"/>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2837588_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="66" mass="7727" checksum="BC47CE7FCBC1F295" modified="2001-03-01" version="1" fragment="single">WLENHTRIRHVFIPVGAGWLNLQEGWWRIFRKAALAGRSFAGPPEVEHAPRLATAQLNTRTRPWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C6</accession>
    <name>Q9K4C6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 3-hydroxybutyryl-coA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5385</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629524.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030215.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5385"/>
    <dbReference type="GeneID" id="1100825"/>
    <dbReference type="KEGG" id="sco:SCO5385"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5465"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K4C6"/>
    <dbReference type="OMA" id="CKLGFGH"/>
    <dbReference type="PhylomeDB" id="Q9K4C6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="186"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB94556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="30103" checksum="D0EB5CB0351E4248" modified="2000-10-01" version="1">MARKLAVIGAGLMGSGIAQVSAQAGWEVVLRDVTDEALRRGTDGIRASYDKFVAKGRLDADDAEAALGRITATTDLDAAADADVVVEAVFEKLEVKHEIFRTLDKLVKDGAILASNTSAIPITKIAAVTERPERVVGTHFFSPVPMMQLCELVRGYKTSDETLATAREFAESTGKTCIVVNRDVAGFVTTRLISALVVEAAKLYESGVATAEDIDLACKLGFGHAMGPLATADLTGVDILLHATGNIYTESQDEKFAPPELMRRMVDAGDIGRKSGQGFYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4H7</accession>
    <name>Q9K4H7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031539.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7248"/>
    <dbReference type="GeneID" id="1102686"/>
    <dbReference type="KEGG" id="sco:SCO7248"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7348"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_2_1_11"/>
    <dbReference type="OMA" id="WCKPSCG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="206" mass="21924" checksum="F4445689B45D5DBF" modified="2000-10-01" version="1">MPIIGRMQDSPSRDTRIALDLALTVRHDGQGGVADELADPAGLTAWAGAHPGVVPDAEVFEADASTLAAVRDVRAAARALFARAVRPGEPSPADAARLLPVPQALRLLNEAAARTPTVPVLAWADAAEPVVRAAPAQGVRADLAAALAQAVIGFLAGPDLKRLRACHAPRCVRYFLKEHPRQEWCKPSCGNRARVARHQDRQRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXJ5</accession>
    <name>Q9KXJ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626572.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028282.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2325"/>
    <dbReference type="TCDB" id="3.A.1.32.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1097759"/>
    <dbReference type="KEGG" id="sco:SCO2325"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2362"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052659_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXJ5"/>
    <dbReference type="OMA" id="EPMFFLM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017196">
        <property type="entry name" value="ECF_substrate-spec_UCP037395"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037395">
        <property type="entry name" value="UCP037395_ABCper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="29209" checksum="9DEE599E75D659C9" modified="2000-10-01" version="1">MTGGSPPQRQARAVRLGPRSIAALVLVSAVGVAGFGWPFLAPPDASLNAHAQDAPWLFAGVLVLLVAVVAATISESGLGPKAVAMLGVLAAAGAALRPIGAGTAGLEPMFFLMVLSGRVLGPGFGFVLGSVTMFASALLTGGVGPWMPFQMLAMGWFTMGAGLLPGPDRLRGRAELLMLAAYGFLAAFAYGTVMNLAGWTFMNTLASNIAFDPDASIADNLARFLAYCLATSLGWDGGRAAMTVVLTLALGTPVLKALRRATRRAAFETPVTFEKPDEVSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXW2</accession>
    <name>Q9KXW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4279</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628451.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029549.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4279"/>
    <dbReference type="GeneID" id="1099719"/>
    <dbReference type="KEGG" id="sco:SCO4279"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4347"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111226_4_0_11"/>
    <dbReference type="InParanoid" id="Q9KXW2"/>
    <dbReference type="OMA" id="AFLDIDW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="17240" checksum="4C6CC2AA48B515F9" modified="2000-10-01" version="1">MTTSTGPRLEPITPANIEAALAIRVRPEQEFAVDPVVKSLAEAYVHPGKAWPRLILDGERPVGFLMGFFGVDWYDDGSALRSGLWRLNIAAEEQGRGYGRFAVRAVAAEIRRRGGTECFVTWHPGEHGPENFYLGLGFRPNGEKSEEETVGVLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY75</accession>
    <name>Q9KY75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5027</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629179.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030012.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100468"/>
    <dbReference type="KEGG" id="sco:SCO5027"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5105"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047003_0_1_11"/>
    <dbReference type="OMA" id="MWPRWRQ"/>
    <dbReference type="PhylomeDB" id="Q9KY75"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="397" mass="42613" checksum="58BD3F7B9B1F312C" modified="2000-10-01" version="1">MTKSTGITWAAASARRLERQFLARRARTGTPVADVAAAMLGVHAQVLSAAELSVGLRADGVTRTDVRDALWPTAPLAPPAPALVKTHGPRGTVHLLPARDLPMWCAALPAIPAGPAAFPTDVRLTGEQAGQVVAAIADALDGTFLTVDELGEEVVARTGPWAGDLVMPAFQTMWPRWRQVLHRAGQCGALSFGPNRGRRVTYTRPPRFTPLPPEEASRLLARRYLYAYGPATPQHFARWLAAPPGWAKARYAELAAAGEIEEVRFEGAPAWVAAGDTAFPDAPERDELLRGVRLLPYFDAYVVAAQPRELLFPGAAYRRALAGGQAGNFPVLLVDGVAAGVWHQRRRGRRTTVTVEPLARLTARQERELADCVERVGAVLEAAAELVIGEVTVGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY77</accession>
    <name>Q9KY77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5025</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973952.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5025"/>
    <dbReference type="GeneID" id="1100466"/>
    <dbReference type="KEGG" id="sco:SCO5025"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5103"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079903_1_0_11"/>
    <dbReference type="OMA" id="YGYEDMI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="305" mass="33100" checksum="F73C520574146F50" modified="2000-10-01" version="1">MRSSFMPPRQVKIGDAAAFVGSTPRAIRHYHEIGLLPEPERGSDGRRRYGYEDMIRLLWIRRTADAGIALDDIRDAFATGTDSAGAESGEDVAGILERLEETLAEREAELRRQRAAVRRMRTEGSRTGLLSDFVTERLKSAPEGSLRQADLDSLLVTERILGPLGAAVQATRFVVLATHPALREESDRVDDAEEALDDGVAVDDPRVAQVAAERRAFESALEAVIEESGPGADDDALFDAWDTLHPAADGAGEADSVSAFEATGWMPYDFSPARLRCMELAAELAADPSARDNTAAQSYRAEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYF3</accession>
    <name>Q9KYF3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4117</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628295.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029445.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KYF3"/>
    <dbReference type="STRING" id="100226.SCO4117"/>
    <dbReference type="GeneID" id="1099554"/>
    <dbReference type="KEGG" id="sco:SCO4117"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4178"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021839_3_0_11"/>
    <dbReference type="OMA" id="SSWVWQR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NPCBM" evidence="6">
        <location>
            <begin position="542"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB92370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="687" mass="70939" checksum="B6AD2F58253C5889" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYP1</accession>
    <name>UBIX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="1">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiX</name>
        <name type="ordered locus">SCO4492</name>
        <name type="ORF">SCD69.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB92113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628657.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974457.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KYP1"/>
    <dbReference type="SMR" id="Q9KYP1"/>
    <dbReference type="STRING" id="100226.SCO4492"/>
    <dbReference type="GeneID" id="1099932"/>
    <dbReference type="KEGG" id="sco:SCO4492"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4562"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYP1"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="PhylomeDB" id="Q9KYP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0637">Prenyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000134972" description="Flavin prenyltransferase UbiX">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <sequence length="216" mass="22615" checksum="9131DBC9DB521649" modified="2000-10-01" version="1">MPWIVGVSGASGTPYAAAVLRALLAAGESVDLVVSRASRLTLLDETGISFRDAHWRHDLREWLARGADGKPDTFDADVSGVRHWSAGDLAAGPSSGSYPTKGMLIVPASTACVAGVALGLSKDLLQRAASVTLKERRRLVVAVRETPLDGRTLRHLVTLDDAGASVVPASPAFYAGATHIQDLVDFVAGRVLDAAGVGHGLYRRWRGDLGGARPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYR5</accession>
    <name>Q9KYR5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629828.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030398.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5700"/>
    <dbReference type="DNASU" id="1101139"/>
    <dbReference type="GeneID" id="1101139"/>
    <dbReference type="KEGG" id="sco:SCO5700"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5789"/>
    <dbReference type="eggNOG" id="COG3570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061172_2_1_11"/>
    <dbReference type="InParanoid" id="Q9KYR5"/>
    <dbReference type="OMA" id="RLWVEPP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB91136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="32635" checksum="F724C66D682C942D" modified="2000-10-01" version="1">MAFEPPRRLVRAFGETAPEGDDWLATLPEVAERAVARRGLTVERVQVPGGRSSLVVLVRTAEGAPAVLKLAPRRARPESERAALVHWGGRGAVQVREEGDEEGVLLLERLHPDVSVRSLPEAKALLEAAGTLRRLWVEPPGSHPFETVAERTGRQAEAMRAGAAADAQVAPLVDAALAARAELLGGPSEQRLLHGTFRQSKVLAGDRMPWLAVGPDPVVGESAFDLARLVRDRVEDLIAQPSGASTTRRRIKRLAESLEVDQERLRGWTLFRAVESGVRARRVGRERDAELLLEFAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZE3</accession>
    <name>Q9KZE3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7010</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631075.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972134.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KZE3"/>
    <dbReference type="STRING" id="100226.SCO7010"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1102448"/>
    <dbReference type="KEGG" id="sco:SCO7010"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7112"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_11"/>
    <dbReference type="InParanoid" id="Q9KZE3"/>
    <dbReference type="OMA" id="VLMVETY"/>
    <dbReference type="PhylomeDB" id="Q9KZE3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="534" mass="59155" checksum="DBF7C6B653B4EA63" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN5</accession>
    <name>Q9KZN5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625680.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027764.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1397"/>
    <dbReference type="GeneID" id="1096823"/>
    <dbReference type="KEGG" id="sco:SCO1397"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1407"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058983_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZN5"/>
    <dbReference type="OMA" id="TEFMVPP"/>
    <dbReference type="PhylomeDB" id="Q9KZN5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="35240" checksum="9C5DD50557E00D49" modified="2000-10-01" version="1">MTGGVAALEILARPESGDVLAEARRDPELDGLLAVSALRAAVRRETLLPLHVNVFAGTLADLGGLQPLHDAVREAGRLPWEVTLDVCPPYTHVPRRALLDAVGVLRGQGFRIAADGVGDGDAPLRLLADLAPELVKLDASLLARPAAVRAMRVLCDGSGALLAVEGVETEAQCAVARSAGAQLAQGELFAPPARLPAADVYVPPGSPGLVPTPRPGPPVRQFVRPAALLPATASAGRVRALLTGSPDVSGVLLVDRDGIPVRSVHRSRFLLSMSGRYGHALYADRPAAKLGDPPRTVGVDATAWEVLDVVAVGDPSRTSDDVRGRGGRARAVCGRRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L086</accession>
    <name>Q9L086_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2460</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626703.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028365.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2460"/>
    <dbReference type="GeneID" id="1097894"/>
    <dbReference type="KEGG" id="sco:SCO2460"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_1_1_11"/>
    <dbReference type="OMA" id="DACIVMQ"/>
    <dbReference type="PhylomeDB" id="Q9L086"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB86125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="15966" checksum="69301AF4CEBBADAB" modified="2000-10-01" version="1">MSSVKQFQVTFDCAEPERLARFWCEVLGYVVPPPPEGFATWDQYQRSRPPEERDAWFACVDPSGVGPRLYFQRVPEGKAAKNRVHLDVRVGTGLVGEERLAALDAERARLVPLGAVHVRTLYDGNDACIPMQDIEGNEFCID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-15" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L091</accession>
    <name>SPEE1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyamine aminopropyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putrescine aminopropyltransferase 1</fullName>
            <shortName evidence="1">PAPT 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spermidine synthase 1</fullName>
            <shortName evidence="1">SPDS 1</shortName>
            <shortName evidence="1">SPDSY 1</shortName>
            <ecNumber evidence="1">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">speE1</name>
        <name type="ordered locus">SCO2455</name>
        <name type="ORF">SCC24.26c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626698.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976349.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L091"/>
    <dbReference type="SMR" id="Q9L091"/>
    <dbReference type="STRING" id="100226.SCO2455"/>
    <dbReference type="PRIDE" id="Q9L091"/>
    <dbReference type="GeneID" id="1097889"/>
    <dbReference type="KEGG" id="sco:SCO2455"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2497"/>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034289_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L091"/>
    <dbReference type="OMA" id="SFGEWGY"/>
    <dbReference type="PhylomeDB" id="Q9L091"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000156508" description="Polyamine aminopropyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="1">
        <location>
            <begin position="233"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine synthase">
        <location>
            <begin position="205"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="374"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <sequence length="531" mass="57754" checksum="EDAB4E62B9FB3660" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0C8</accession>
    <name>RL5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">SCO4714</name>
        <name type="ORF">SCD31.39</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628873.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974255.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0C8"/>
    <dbReference type="SMR" id="Q9L0C8"/>
    <dbReference type="STRING" id="100226.SCO4714"/>
    <dbReference type="GeneID" id="1100155"/>
    <dbReference type="KEGG" id="sco:SCO4714"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4785"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0C8"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="PhylomeDB" id="Q9L0C8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124999" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="185" mass="20853" checksum="2C5DE5DAA7DC9E11" modified="2000-10-01" version="1">MATTTTPRLKTKYREEIAGKLREEFSYENVMQIPGLVKIVVNMGVGDAARDSKLIEGAIRDLTTITGQKPAVTKARKSIAQFKLREGQPIGAHVTLRGDRMWEFLDRTLSLALPRIRDFRGLSPKQFDGRGNYTFGLTEQVMFHEIDQDKIDRTRGMDITVVTTATNDAEGRALLRHLGFPFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0J5</accession>
    <name>Q9L0J5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4670</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628830.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029803.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4670"/>
    <dbReference type="CAZy" id="CBM12">
        <property type="family name" value="Carbohydrate-Binding Module Family 12"/>
    </dbReference>
    <dbReference type="MEROPS" id="S01.265"/>
    <dbReference type="GeneID" id="1100111"/>
    <dbReference type="KEGG" id="sco:SCO4670"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4742"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0J5"/>
    <dbReference type="OMA" id="FYSGAQA"/>
    <dbReference type="PhylomeDB" id="Q9L0J5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037295">
        <property type="entry name" value="Alpha-lytic_protease_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54806">
        <property type="entry name" value="SSF54806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176804" evidence="8">
        <location>
            <begin position="33"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="9">
        <location>
            <begin position="417"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="463" mass="47025" checksum="38E972733BA946DE" modified="2000-10-01" version="1">MPHRHRHHRAVGAAVAATAALLVAGLSGSASAGTAPAGSAPTAAETLRTDAAPPALLKAMQRDLGLDRRQAERRLVNEAEAGATAGRLRAALGGDFAGAWVRGAESGTLTVATTDAGDVAAIEARGAEAKVVRHSLADLDAAKARLDTAAAGLNTADAPVWYVDTRTNTVVVEAIRPAAARSLLTAAGVDGSLAHVKNRTERPRTFYDLRGGEAYYINNSSRCSIGFPITKGTQQGFATAGHCGRAGSSTTGANRVAQGTFQGSIFPGRDMAWVATNSSWTATPYVLGAGGQNVQVTGSTASPVGASVCRSGSTTGWHCGTVTQLNTSVTYQEGTISPVTRTTVCAEPGDSGGSFISGSQAQGVTSGGSGDCRTGGETFFQPINALLQNYGLTLKTTGGDDGGGDDGGGDDGGEEPGGTWAAGTVYQPGDTVTYGGATFRCLQGHQAYAGWEPPNVPALWQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Z4</accession>
    <name>Q9L0Z4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1465</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625746.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027799.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1465"/>
    <dbReference type="GeneID" id="1096891"/>
    <dbReference type="KEGG" id="sco:SCO1465"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1474"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027068_0_0_11"/>
    <dbReference type="OMA" id="HQGSFIR"/>
    <dbReference type="PhylomeDB" id="Q9L0Z4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="401" mass="43448" checksum="24D816EC4CB822F1" modified="2000-10-01" version="1">MSRPGARTLGILCVCLVLLGAGVYAGVRWARDWQGSVTLLANWSGTEREQFEEHVIEPFEEKYRIDVVYQGSSALSQVLAADMAAGNPPDVAVLPGPGELLAYAVDGRLHPLDGLFDAGDYDRFWAPEVTVPGQGAHTYWLPVKTGLKSMVWYAGPAPTAGTAGPPARWCAGLESGATSGWPGTDWVEDILLQQAGPRVYEEWANGRLPWTDDAVRKAWTTWADLVGAGDRARVEQVLTTAFDADCAPGSLEHQGSFRAGHWRQEGGDHVHSSEVVPGAGADAGAWEVSGDLAAVLNPTPEAERLIRYLADPDTALPEYTANRSAAADADQDATEREIWAILREPGRTRCWDASDAMPRTTRDAFHLAVLRTFADPTALDTRLRELDRLREPQNLPVCGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L186</accession>
    <name>Q9L186_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7389</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631441.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971753.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7389"/>
    <dbReference type="GeneID" id="1102827"/>
    <dbReference type="KEGG" id="sco:SCO7389"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7498"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L186"/>
    <dbReference type="OMA" id="RRINCPG"/>
    <dbReference type="PhylomeDB" id="Q9L186"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="30594" checksum="5A8A626300F7DE39" modified="2000-10-01" version="1">MTDSPLQNRTVVVTGAARGLGAALARACALRGARIALLGLEKPRLDALAADLPTPALAVEADVTDPAALADAAGETRRRLGRPSVVVANAGVAHGGPFATSDPAEWGRVVDVNLTGSAHTARAFLPDLLDTAGYHLQIASLASLGAAPMMSAYCASKAGVEAFAHSLRAEVAHRGVAVGIAYLNWIDTDMIRDADRHPVLRELRAHMPPPARRTFSADDVAARLVRALERRRTAVYVPGWLRLVQLGRASLPPVVARLSRRELPRLEAEEELGPTGPLGAGGRAGHAAGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1H3</accession>
    <name>Q9L1H3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2604</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626841.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028450.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1098038"/>
    <dbReference type="KEGG" id="sco:SCO2604"/>
    <dbReference type="eggNOG" id="ENOG503229Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894035_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB75385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="34315" checksum="0FB0A5BB3F311069" modified="2000-10-01" version="1">MSDGIIVAIGGWGTTVVAAAVAAWAALRARRKLDGDVSIFDVWVCEGADLLAEPETDVQLLNAIVPDRPLLDIAVRNDGDRKGLVRRLKVELKGALYVPPIDSPSVVRMPVPVSEPGVMSERRIGPSGSYAINFPLLEGSYGKTVNLEIDPGDVDRFALSLVAKDAARGREFYQVCLFLEGGKGRKVRRQTMSEPMMVPAYGPPSWESPVEIKEYISQIANRVRELAPQGLAEVAVIFNGSFYPHAIGMEEYVSFYENKLKVLATALRACLKHSAHEDRIRGWIDEVERDLTETEQLRRHAADLRATGRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1R4</accession>
    <name>Q9L1R4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630920.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031235.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6850"/>
    <dbReference type="DNASU" id="1102289"/>
    <dbReference type="GeneID" id="1102289"/>
    <dbReference type="KEGG" id="sco:SCO6850"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6960"/>
    <dbReference type="eggNOG" id="ENOG5030R1V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084482_0_0_11"/>
    <dbReference type="OMA" id="RACGWSH"/>
    <dbReference type="PhylomeDB" id="Q9L1R4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB72355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="27763" checksum="9872C5A96AB51822" modified="2000-10-01" version="1">MPSTADTVEVDFITPRHLAGGGDPAWITVPLHRACGWSHGHDPLMPRALLSSPDQKALLRLEPDPDGQWWTLNHTAESGRPAWYASFGARTPVELIAAFTDALTAPAPPTDAPCDPFEPLRQIAWSAPAVGADGLVSPDGTAYVQRQGSADGPGAWFVTVTLGPRPVWQARFDAHTPEHLVAAFTTALADPKPALRTDSGRSLPTRNPNVVTRKTTDVLAVDIAGALEERVQTLTTRHPLPPANPMPPTPPPTRHGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L259</accession>
    <name>Q9L259_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2662</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626897.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028493.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2662"/>
    <dbReference type="GeneID" id="1098096"/>
    <dbReference type="KEGG" id="sco:SCO2662"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2709"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L259"/>
    <dbReference type="OMA" id="NCVGMRP"/>
    <dbReference type="PhylomeDB" id="Q9L259"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="305" mass="31530" checksum="3DE78AF0944B9D3C" modified="2000-10-01" version="1">MAVVAADGEVLATARGGAFRPPAVGVERAVDALADAVTRAFAAAGVTAVGHVSACLANADLPVEEEQLAAALHARAWGGSVEVRNDTFALLRAGVDEPLGVAVVCGAGVNCVGMRPDGRTARFPAIGRISGDWGGGWGLAEEALWYAARAEDGRGEPTELARTLPAHFGLDSMYALIEALHLRRVEPVRRHELTPVLFATAAGGDPLARSVVDRQADEVVAMATVALTRLDLLAEPAPVVLGGSVLAARHPQLDQRIRELLAARAPKAVPRVVAARPVLGAVLLGLDHVGAAPGAGERAREHFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2C5</accession>
    <name>Q9L2C5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO2494</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626736.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976309.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2494"/>
    <dbReference type="GeneID" id="1097928"/>
    <dbReference type="KEGG" id="sco:SCO2494"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2537"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_11"/>
    <dbReference type="InParanoid" id="Q9L2C5"/>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="PhylomeDB" id="Q9L2C5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="429"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="545"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB69782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="909" mass="99025" checksum="21634DDC06424DA2" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCY6</accession>
    <name>Q9RCY6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027449.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0924"/>
    <dbReference type="GeneID" id="1096347"/>
    <dbReference type="KEGG" id="sco:SCO0924"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.918"/>
    <dbReference type="eggNOG" id="ENOG502Z7U4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077968_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RCY6"/>
    <dbReference type="OMA" id="QHGFWSA"/>
    <dbReference type="PhylomeDB" id="Q9RCY6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="27026" checksum="DF8EF96EC7BB8A91" modified="2000-05-01" version="1">MVPVTSCDMALATRTDRRPSMARTVWDSTVGKKTVMAVSGLVMLLYLVAHMIGNLKIYFGVEEFNHYAHWLRTVGEPFMHYEWTLWLIRVVLVVAVVAHAVSAYQLSRRDIKARPSKYVHKKARSSYATRTMRWGGIILGLFIVWHILDLTTGTVHSGGFETGKPYQNVVDTFSTWYGNVIYIVAMLALGLHIQHGFWSAAQTLGAGSRTRDRALKTTANVLALLLTIGFIAVPVGVMTGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDB8</accession>
    <name>Q9RDB8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted chitin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2833</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627062.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975967.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RDB8"/>
    <dbReference type="STRING" id="100226.SCO2833"/>
    <dbReference type="CAZy" id="AA10">
        <property type="family name" value="Auxiliary Activities 10"/>
    </dbReference>
    <dbReference type="GeneID" id="1098267"/>
    <dbReference type="KEGG" id="sco:SCO2833"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2891"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047929_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDB8"/>
    <dbReference type="OMA" id="FRWQFTA"/>
    <dbReference type="PhylomeDB" id="Q9RDB8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176866" evidence="1">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21218" checksum="3A9B95F9C9F30BFA" modified="2000-05-01" version="1">MRTRTKLYAAALGMATTGALVLSSGGASGHGYTDLPVSRQKVCQNGTVGGCGAIQWEPQSVEGPKGFPASGPADGTICSAGHGSFAALDSPKQPNGQAWPTTRVNGGQSYTFRWQFTARHATTDFKYYVTKPGWNQNHNLARSDLNLTPFFTVPYGGKQPPATLSHSGTLPSGLSGHHVILAVWTVHDTGNAFYACSDVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDF9</accession>
    <name>Q9RDF9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2769</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627000.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028574.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2769"/>
    <dbReference type="GeneID" id="1098203"/>
    <dbReference type="KEGG" id="sco:SCO2769"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2826"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RDF9"/>
    <dbReference type="OMA" id="GKGAFPW"/>
    <dbReference type="PhylomeDB" id="Q9RDF9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="7">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="5">
        <location>
            <begin position="220"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="6">
        <location>
            <begin position="409"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB66308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="564" mass="58918" checksum="59D677CA9497A919" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP3</accession>
    <name>Q9RDP3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626640.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028325.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2394"/>
    <dbReference type="GeneID" id="1097828"/>
    <dbReference type="KEGG" id="sco:SCO2394"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2435"/>
    <dbReference type="eggNOG" id="COG2039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048887_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RDP3"/>
    <dbReference type="OMA" id="YWARLGM"/>
    <dbReference type="PhylomeDB" id="Q9RDP3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="417" mass="44334" checksum="98337EB5C48B7AAD" modified="2000-05-01" version="1">MAGLAAPTTATAAPGAGGAAPAPTVEERRLDGEVPQEILRRSGFAAVAPAFARGLGRADSYREARAVVAREGAALWRRAVDRVQGRGPARGDLSRDDDRPLYWARLGMTRELRTWEPGFGLGERQRAALLTELERTSRGQADLRLPRGHRDGHGGHGKGVKRVLLTGFDPFTLDRDVRISNPSGAVALALDGTVIDTPDGPARVETAVFPVRWADFAQGTVERALRPYLPRVDLFTTVSQGRVGRFDVERTNGAWRGGFPDNDNVSRTETVPVADPASQPQWTTTTLPYAAITAADTGRFPVYDNTAVTEIPAGGDEPVVRPDGPTPGSTAREGGGGNYLSNEIAYRATLLRDRLGLHGTLPGGHVHTPVLQFGTGNTDPATGAVTDPEFVRNRLDIVAQARAIVAVAVSAPGTDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS6</accession>
    <name>Q9RDS6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2241</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626490.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976572.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RDS6"/>
    <dbReference type="STRING" id="100226.SCO2241"/>
    <dbReference type="GeneID" id="1097674"/>
    <dbReference type="KEGG" id="sco:SCO2241"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2279"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_3_11"/>
    <dbReference type="InParanoid" id="Q9RDS6"/>
    <dbReference type="OMA" id="TFYTHPE"/>
    <dbReference type="PhylomeDB" id="Q9RDS6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB66175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="453" mass="50553" checksum="4A7A0590218EBED3" modified="2000-05-01" version="1">MDKQQEFVIRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPSTFQVLPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRALARTSDLGFTFYTHPEIEFFLLKDKPVDGSVPTPADNSGYFDHTPQNIGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNVMTFRLVMKQVALEQGLQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFYESGAEYQLSKVGRSFIAGLLRHAAEISAVTNQWVNSYKRIWGGTERTAGAGGEAPSYICWGHNNRSALVRVPMYKPGKTGSARVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPPGAEDDVWALSDAERRALGIEPLPQNLGEALALMERSDLVAETLGEHVFDFFLRNKRQEWEEYRSQVTAFELRKSLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIW5</accession>
    <name>Q9RIW5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0149</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624486.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026884.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095573"/>
    <dbReference type="KEGG" id="sco:SCO0149"/>
    <dbReference type="HOGENOM" id="CLU_1377417_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="20734" checksum="AD280A06461E171F" modified="2000-05-01" version="1">MEGRWFLGSGQLEDLLGSDQQVVVAVKAEVAGDAGAGSVGTDDEPRPDSRRPVATEQVERVAPASGVARAQDDAHAGGRSGGRRRGVERRHVSYAVLVAAADQGDGAAQVGRVEDDPSNRWAEVLGRQREVVECLPHEDPRGADRADKTGSPVDQEDAVALPCEERGGVEAGQSGADDEDIRTGRGPEEVGAGRSAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ55</accession>
    <name>Q9RJ55_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1653</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625928.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027903.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1653"/>
    <dbReference type="GeneID" id="1097084"/>
    <dbReference type="KEGG" id="sco:SCO1653"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1670"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049030_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ55"/>
    <dbReference type="OMA" id="LCGWCDH"/>
    <dbReference type="PhylomeDB" id="Q9RJ55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="284" mass="31862" checksum="4A4DB4E752DFACBA" modified="2000-05-01" version="1">MATAPASLSPSRAGDFMQCPLLYRFRVIDRLPEKPSEAATRGTLVHAVLERLFDAPAAERTAPTARALVPGQWDRLRESRPEVGELFADDPEGERLAQWLAEAERLVERWFSLEDPSRLEPAERELFVEAELDSGLRLRGIIDRVDVAPTGEVRIVDYKTGKAPRPQYAEGALFQMKFYALVVWRLKKVVPRRLQLVYLGSGDVLTYDPVLADLERVERKLLALWEAIRLATETGDWRPRPTKLCGWCDHQAHCPEFGGTPPPYPLPVRAADSGAVAQGRMGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJA6</accession>
    <name>Q9RJA6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gas vesicle synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0658</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624967.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978204.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0658"/>
    <dbReference type="GeneID" id="1096081"/>
    <dbReference type="KEGG" id="sco:SCO0658"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.642"/>
    <dbReference type="eggNOG" id="ENOG50330IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150705_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJA6"/>
    <dbReference type="OMA" id="ERMDDLC"/>
    <dbReference type="PhylomeDB" id="Q9RJA6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="100" mass="11043" checksum="CF22780AE423996D" modified="2000-05-01" version="1">MTAPRDRAAHALDLDPERVANDLAALVLTVVELLRQLMERQAVRRFDEGTLSAEQEDRLGTALMLLDERMDDLCAQHGLSRSDLNLDLGPLGPLLADPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB1</accession>
    <name>Q9RJB1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0653</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624962.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027274.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0653"/>
    <dbReference type="GeneID" id="1096076"/>
    <dbReference type="KEGG" id="sco:SCO0653"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.637"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078525_3_0_11"/>
    <dbReference type="OMA" id="MNDSRTA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="19284" checksum="3C75CB34DC32F3A3" modified="2000-05-01" version="1">MNDSRTAMAAAVAGGYLLGRTKKAKLAFAVGSYLVGRRVGLSPGQVLGQGLGSLQRAPQFQELTDQVRGELLTAGRAAVTAAANRRLTTFADTLRDRTDALTGEDRRDDDSDENGDEDAYFDEEDRAEDRRPAPAPPRKTAKKAAPRKAAPPAKKAAKKTAAKKTAPGKRAAGPGVRRGGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ2</accession>
    <name>Q9RJQ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0588</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624900.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027225.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0588"/>
    <dbReference type="GeneID" id="1096011"/>
    <dbReference type="KEGG" id="sco:SCO0588"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.569"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021841_2_1_11"/>
    <dbReference type="OMA" id="RSSRAWN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
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    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="333"/>
            <end position="444"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="575" mass="60097" checksum="9EE13F700D0AF88A" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK06</accession>
    <name>Q9RK06_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0500</name>
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    <organism evidence="3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36418">
        <property type="entry name" value="T36418"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624817.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027163.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0500"/>
    <dbReference type="GeneID" id="1095923"/>
    <dbReference type="KEGG" id="sco:SCO0500"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.480"/>
    <dbReference type="eggNOG" id="ENOG5033A76">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186976_2_0_11"/>
    <dbReference type="OMA" id="PDSDGHY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035172">
        <property type="entry name" value="DUF5302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17227">
        <property type="entry name" value="DUF5302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8377" checksum="05D4F11001492C1C" modified="2000-05-01" version="1">MTEESSSQTGSEPAEAEGTALTPDADGQYNLKDKFREALERKRGKQAEAAALAANADVAKIRGTHGPAASQRSFRRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKT8</accession>
    <name>Q9RKT8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6254</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630354.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030771.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6254"/>
    <dbReference type="GeneID" id="1101695"/>
    <dbReference type="KEGG" id="sco:SCO6254"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6368"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9RKT8"/>
    <dbReference type="OMA" id="HNVISDG"/>
    <dbReference type="PhylomeDB" id="Q9RKT8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB60173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="24557" checksum="132D7AD8ACD6950A" modified="2000-05-01" version="1">MTAIRLLLVDDDPLVRAGLSLMLGGAEDVEIVGEAADGDEVVALVDRTRPDVVLMDIRMPGTDGLTATERLRSRPDAPQVVVLTTFHADEQVLRALRAGAAGFVLKDTPPAEILHAVRRVAAGDPVLSPAVTRRLMEQAAGTAPDARHARRTRARARVDTLNDREREVAVAVGRGMANADIASHLFMSVATVKAHVSRILAGLDLDNRVQIALLAYDAGLLDDYHDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1N9</accession>
    <name>Q9S1N9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0252</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37167">
        <property type="entry name" value="T37167"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624584.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026961.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0252"/>
    <dbReference type="GeneID" id="1095676"/>
    <dbReference type="KEGG" id="sco:SCO0252"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.224"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_1_11"/>
    <dbReference type="InParanoid" id="Q9S1N9"/>
    <dbReference type="OMA" id="RRMGIED"/>
    <dbReference type="PhylomeDB" id="Q9S1N9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="415" mass="46017" checksum="BE1F17724F533097" modified="2000-05-01" version="1">MAQRSGTTSLRVLVAGGGIAGHALAYWLARGGHRVTVRERYPDLRATGAQIDLRGQGIEAVRRMGLLDTVRGRLVDEAGVAFLDARGRPRATLMANTSGRGRQSLTSEYEIMRGDLVRILHEATGNDVEYVYGTSVDGFDQDEHEVVAHCSDGSSETYDLLVAADGQGSRLRRAILPDGTDPYWRVGIHMAYWFVPRIASDSNVRDTCMVPGGRQIMRRSHNPTETQVYFVLREDSAQASAIHREPVEKQQEFWASRFRDAGWQTERFVEGMRTSPFFYSQEIVQVRTGTWSRGRVVLAGDAAHCASPYSGMGTSGGLVGAHVLAGEINRRPDDLPTALAHYDTTLRPFTDEIQGEVNPRLLKLAMPMTQRAIDAFLTVTGMATRLRVPDLATRFSKEDRGGAWRLPHYPELRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Q3</accession>
    <name>Q9S1Q3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0238</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37153">
        <property type="entry name" value="T37153"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624570.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026948.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095662"/>
    <dbReference type="KEGG" id="sco:SCO0238"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.211"/>
    <dbReference type="eggNOG" id="ENOG502ZKFI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129244_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="175" mass="18863" checksum="3C842DF04D98FAD2" modified="2000-05-01" version="1">MSDRSLSSAWLASWTSRVAETLEAMTDEFERRHGFPPGVNEVRRADSADQAAARTLARDSLVPADMVTFYDSIGEVAWADVGNGCFLDPAADVLLRFKHYGTVDVGAGQRDRGLVIGSNGGGLSYVAGPGGMIHRTRTASLDEPELDRVADDLRQFLELLEGSTRFVTNGDPGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1V0</accession>
    <name>Q9S1V0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0042</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37106">
        <property type="entry name" value="T37106"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624400.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026802.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0042"/>
    <dbReference type="GeneID" id="1095475"/>
    <dbReference type="KEGG" id="sco:SCO0042"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.34"/>
    <dbReference type="eggNOG" id="COG4449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905897_0_0_11"/>
    <dbReference type="OMA" id="RYRPLYN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="34343" checksum="B35370860EF72EFE" modified="2000-05-01" version="1">MNDFLLWAVALGPALLAEGLLARYEVLAYGAGWRAPVTELPEGVPYARGADPDRPPGAYLVYLDGIGKRRVRDSRDGGQLVRAVLAGAPELRVLGQVQPYSPLADPLADRPVWSWLRRRVGLVLFLHNVMQIFVAADRRYRPLYNRAVGSQIATQLRLAGYRPGSGVPVVLLSYSGGAQVATGAVDELRERLDCPLLLIMFGGFHNGANDLTRAEHVHRLTSSADRIERVGTWMFPQRWPLFRGSGWNRAVRAGNVTVHRFDPATHVGPRSYISRSTLLPDGRTHLARTANTVVELIRAHCRSQAAERPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1W3</accession>
    <name>Q9S1W3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37093">
        <property type="entry name" value="T37093"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624387.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026789.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0029"/>
    <dbReference type="GeneID" id="1095462"/>
    <dbReference type="KEGG" id="sco:SCO0029"/>
    <dbReference type="HOGENOM" id="CLU_2318805_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="99" mass="10173" checksum="2CF9373422F04149" modified="2000-05-01" version="1">MDRLVGQWHRTWEPTVRNASGVLEPPGVLWVAVKGWLDALLVGRHGATHPAPGSASATASCRGVRRGVGRGRSAPRPPGAGAGARQARTNGPPGAGPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1W5</accession>
    <name>Q9S1W5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0027</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37091">
        <property type="entry name" value="T37091"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624385.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026787.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0027"/>
    <dbReference type="GeneID" id="1095460"/>
    <dbReference type="KEGG" id="sco:SCO0027"/>
    <dbReference type="HOGENOM" id="CLU_2025353_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="122" mass="13005" checksum="A8E34554849224DF" modified="2000-05-01" version="1">MGRAHRKDVFSVASSSRRMTWSAWGAREFCGVPDLPRTPVVAAAGLHVQPAAPGCPDPSQPFGHGVLVVGTTIGGRGSWPTPPAPAKVRRRAAVYEMPSRAVRPRAARLACGAPHVVPPWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S293</accession>
    <name>Q9S293_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1737</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36759">
        <property type="entry name" value="T36759"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626010.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977089.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1737"/>
    <dbReference type="GeneID" id="1097168"/>
    <dbReference type="KEGG" id="sco:SCO1737"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1755"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132093_0_0_11"/>
    <dbReference type="OMA" id="LCAWRGE"/>
    <dbReference type="PhylomeDB" id="Q9S293"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13193" checksum="683130CC6FE849D8" modified="2000-05-01" version="1">MPVVRSSEGVTHEIHGARFVSYASPRVGSRELCAWRGEIPAGTKAPAHTVDREEVFHLLTGELLITLDGRTERVTAGDTVIIGSGATLAVENPTDRTATSWVTTSVGLTAELADGTRITPPWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2J0</accession>
    <name>Q9S2J0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2013</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35758">
        <property type="entry name" value="T35758"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626274.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976804.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S2J0"/>
    <dbReference type="STRING" id="100226.SCO2013"/>
    <dbReference type="GeneID" id="1097447"/>
    <dbReference type="KEGG" id="sco:SCO2013"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2043"/>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_65_0_11"/>
    <dbReference type="InParanoid" id="Q9S2J0"/>
    <dbReference type="OMA" id="QKTSMDR"/>
    <dbReference type="PhylomeDB" id="Q9S2J0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="4">
        <location>
            <begin position="146"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB52069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="24151" checksum="027CE5FD7FA8613E" modified="2000-05-01" version="1">MTAPESPQPVDVPDDDQSHVPPLTTRVVIAEDEALIRLDLKEMLEEEGYSVVGEAGDGEEAVELAREHRPDLVILDVKMPKMDGISAAEKIAEESIAPVLMLTAFSQRDLVERARDAGAMAYLVKPFSKSDVVPAIEMAVSRFTELKALEKEVADLSLRLETRKLVDRAKSVLQTEYGLTEPAAFRWIQKTSMDRRMSMQQVAEAVIQDAEEKKASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Z0</accession>
    <name>Q9S2Z0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glutamate synthase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2025</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34868">
        <property type="entry name" value="T34868"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626285.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2025"/>
    <dbReference type="GeneID" id="1097459"/>
    <dbReference type="KEGG" id="sco:SCO2025"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2055"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_1_11"/>
    <dbReference type="InParanoid" id="Q9S2Z0"/>
    <dbReference type="OMA" id="DCVGTAH"/>
    <dbReference type="PhylomeDB" id="Q9S2Z0"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB52860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="487" mass="52877" checksum="8084B15B2B24C7B8" modified="2000-05-01" version="1">MADPKGFLNHGREVARTRPVDERVKDWNEVYVPGSLLPIISKQASRCMDCGIPFCHNGCPLGNLIPEWNDYAYREDWSAASERLHATNNFPEFTGRLCPAPCESACVLGINQPPVTIKNVEVSIIDKAWETGDVAPRIPERLSGKTVAVIGSGPAGLAAAQQLTRAGHTVAVYERADRVGGLLRYGIPEFKMEKRHINRRIEQMRAEGTRFRTGVEIGRDLKATDLKKRYDAVVIAAGSTTARDLPVPGRELNGIHQAMEYLPLANKVQEGDYVAPPITAEGKHVVVIGGGDTGADCVGTAHRQGAASVTQLEIMPRPGEERDAVRQPWPTFPMLYKVTSAHEEGGERVYAVSTTHFEGDEDGNVQWLHMSEVEFVDGKLTSKPGTERKIPAQLVTLAMGFTGTDKDNGLVDQFGLELDERGNIARDADFQTNVPGVFVAGDAGRGQSLIVWAIAEGRSAARGADRFLTGASDLPAPIRPTDRALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX02</accession>
    <name>Q9WX02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3332</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36280">
        <property type="entry name" value="T36280"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627542.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028915.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3332"/>
    <dbReference type="GeneID" id="1098766"/>
    <dbReference type="KEGG" id="sco:SCO3332"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3392"/>
    <dbReference type="eggNOG" id="ENOG5032U91">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082059_2_0_11"/>
    <dbReference type="InParanoid" id="Q9WX02"/>
    <dbReference type="OMA" id="PVDTMVW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="24968" checksum="E04FF1D776DC067A" modified="1999-11-01" version="1">MTKPRKSRTVVSLLLDVGVPVGSYYLLKGAFGMSAVAALGWSSAGPVLRTGWGVLRQREVNVLPLLILLANLAGLLIGFGTGDARLMLAKDSAVTSLVGFALLGSVALGRPMMTATLKPWLVKGDAGREAAWGRLRRESPAFRRAELRFSAVWGVAFVGECGVRIVRVYALPVDTMVWLGTVVMIVTMLVAFVVSGALGAGPMVHMIGAAVTTDDSADAFDAVLEAEKNSSLVGSTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7U7</accession>
    <name>Q9X7U7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35356">
        <property type="entry name" value="T35356"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631308.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031543.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7252"/>
    <dbReference type="GeneID" id="1102690"/>
    <dbReference type="KEGG" id="sco:SCO7252"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7354"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_6_0_11"/>
    <dbReference type="OMA" id="FTGMDLM"/>
    <dbReference type="PhylomeDB" id="Q9X7U7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="502" mass="54855" checksum="56B83E90016ADE59" modified="1999-11-01" version="1">MSKEPNTRLSDLFGLAGWSKGELARLVNRQAAAMGHPQLATDTSRVRRWIDMGEIPRDPVPRVLAALFTERLGRVVTIEDLGLVRHGRAGKRPHDGSEEHPDGVPWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSALSSAMHDWLHTDPALAADAPDLHQPLHADPAGFDRYEAAPIGSQEVEELERSVEVFRAWDAARGGGLQRKAVVGQLNEVGGMLAYHHPPHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRAGEALSRAARQMVHLGKPDEALDLMKLAQSGSGEQVLPRTKAMLYTIEAWAQASMGKGQAMRRTLGRAEDLFVSDKADVPPPDWMQTFKEEDLYGMQALAYRTLAEFEPGAAAHAQHYADKALALRIDGRQRSKIFDYLSMASACFIADDPEQADRYARLALVSMGSNSSQRTWDRLRQMYRLTAEYAGYPKIQELREEIKLALPKGKSPRGKGPGGTVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7V1</accession>
    <name>Q9X7V1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6756</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35396">
        <property type="entry name" value="T35396"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630828.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031159.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6756"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1102195"/>
    <dbReference type="KEGG" id="sco:SCO6756"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6865"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074755_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7V1"/>
    <dbReference type="OMA" id="CGPRRPM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="32112" checksum="19B3B77184FD2B27" modified="1999-11-01" version="1">MKVGAVVITMGNRPEELRALLDSVAKQDGDPVQVVVVGNGSPVPEVPEGVRTVELPENLGIPGGRNVGIEAFGPGGSDVDILLFLDDDGLLARTDTAELCREAFAADDELGIISFRIADPDTGETQRRHVPRLRASDPMRSSRVTTFLGGANAVRTRVLTQVGGLPDAFFYAHEETDLAWRALDAGWMIDYRSDMVLNHPTTAPSRHAVYHRMVARNRVWLARRNLPALLVPVYLGVWMALTLLRRPSRPALKAWFGGFREGWATPCGPRRPMRWRTVWRLTRLGRPPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X825</accession>
    <name>Q9X825_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6058</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35850">
        <property type="entry name" value="T35850"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630167.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030623.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6058"/>
    <dbReference type="GeneID" id="1101499"/>
    <dbReference type="KEGG" id="sco:SCO6058"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6159"/>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_7_2_11"/>
    <dbReference type="InParanoid" id="Q9X825"/>
    <dbReference type="OMA" id="VRANMIA"/>
    <dbReference type="PhylomeDB" id="Q9X825"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="27612" checksum="63DC909E73E4004F" modified="1999-11-01" version="1">MRRLFPVSPATDPTAGPGGGPETDREWSLAELAAAYAYPEPDAHRRTWLRANMVSTLDGAAQHDGRSQPISSAADMRVFGTLRALADVVIAGAETVRQEGYRPGRARADFAEARRAAGQAPVPVIAVVSASLELDFSLPLFTSPAVPTLVLTGAAAAPDRIAAAERAGARVVIAGDGVGVDPARALGALAELGHTRLLTEGGPRLLGQFVAAGVLDELCLTVSPMLTAGDAQRIAGGPAVGVPRRFALASLLEEEGFLFSRYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X881</accession>
    <name>Q9X881_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative large membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3289</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36109">
        <property type="entry name" value="T36109"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627500.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028889.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3289"/>
    <dbReference type="GeneID" id="1098723"/>
    <dbReference type="KEGG" id="sco:SCO3289"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3350"/>
    <dbReference type="eggNOG" id="ENOG5033UNM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032560_1_0_11"/>
    <dbReference type="OMA" id="TQGGMLM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="536" mass="58897" checksum="E30F6599066429B6" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G2</accession>
    <name>Q9X8G2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO3338</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36287">
        <property type="entry name" value="T36287"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627547.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028918.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3338"/>
    <dbReference type="GeneID" id="1098775"/>
    <dbReference type="KEGG" id="sco:SCO3338"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3398"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_7_1_11"/>
    <dbReference type="InParanoid" id="Q9X8G2"/>
    <dbReference type="OMA" id="CGLFTPR"/>
    <dbReference type="PhylomeDB" id="Q9X8G2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="31"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB42664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="28201" checksum="A65858A932E2D590" modified="1999-11-01" version="1">MTTPTAPAPPAPALTPAPTRPLSLARTTATATRVLRQLSHDPRTIALLMLIPCVMLFLLRYVFDGSPRTFDNIGASLLGIFPLITMFLVTSIATLRERTSGTLERLLAMPLGKGDLIAGYALAFGALAIVQSALATGLAVWFLGLDVTGSPWLLLLVALLDALLGTALGLFVSAFAASEFQAVQFMPAVIFPQLLLCGLFTPRDNMHPALEAVSDVLPMSYAVDGMNEVLRHTDMTATFVRDALIVAGCALLVLALGAATLKRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G9</accession>
    <name>Q9X8G9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3346</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36295">
        <property type="entry name" value="T36295"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627555.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975488.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3346"/>
    <dbReference type="GeneID" id="1098783"/>
    <dbReference type="KEGG" id="sco:SCO3346"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3408"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_10_0_11"/>
    <dbReference type="InParanoid" id="Q9X8G9"/>
    <dbReference type="OMA" id="HWFGGKE"/>
    <dbReference type="PhylomeDB" id="Q9X8G9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="21993" checksum="B3E6396CC90993F7" modified="1999-11-01" version="1">MNGDAGGTTRRRGRPPGTESGDTRDRILTTAREEFSERGYEKTSVRGIAKAAGVDPALVHHYFGTKEQVFEAAIEVAFAPALRAPDAIGDAPLDEVGERLTRFILGLWENPASRTPLLAIVRSAVNNETAATVFRRLIATQVLRRVAAQLHLPDAELRVELAAAQLVGCAMLRYVIKVEPLASADPEQIVARLAPVVQGHLTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8H7</accession>
    <name>Q9X8H7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane lysyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3397</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36323">
        <property type="entry name" value="T36323"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627603.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028953.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3397"/>
    <dbReference type="TCDB" id="9.B.111.1.1">
        <property type="family name" value="the 6 tms lysyl trna synthetase (lyss) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1098834"/>
    <dbReference type="KEGG" id="sco:SCO3397"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3460"/>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_7_3_11"/>
    <dbReference type="InParanoid" id="Q9X8H7"/>
    <dbReference type="OMA" id="RWEPRFV"/>
    <dbReference type="PhylomeDB" id="Q9X8H7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="9">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="245"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="601" mass="65950" checksum="70D67BC0F2235740" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC9</accession>
    <name>Q9XAC9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1927</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35999">
        <property type="entry name" value="T35999"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626192.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976892.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1927"/>
    <dbReference type="GeneID" id="1097361"/>
    <dbReference type="KEGG" id="sco:SCO1927"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1953"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060091_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAC9"/>
    <dbReference type="OMA" id="HATDCRL"/>
    <dbReference type="PhylomeDB" id="Q9XAC9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB50752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="27931" checksum="0D239D41795A0B93" modified="1999-11-01" version="1">MSTPPPTGPLVTRGTLAAGLRELGVRTGDTLLAHSSLSALGWVCGGPVAVVRALLDVLGPDGTLVVPTQTGDLSDPALWTSPPVPEEWWETVRAATPAYDPLITPSRGVGVVPETVRTWPGARRSAHPQTSFAALGGRAAEVVAGHATDCRLGERSPLAALERLDARVLLLGAGYDACTAFHLAEYRIPAPLVEVGRPGPVGWERVTEVSITSERFDELGHDFERDRPVARGRVGAADVRLFSLPDAVAYAERWLPVHRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAH0</accession>
    <name>Q9XAH0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5330</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35600">
        <property type="entry name" value="T35600"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629471.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030179.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5330"/>
    <dbReference type="GeneID" id="1100770"/>
    <dbReference type="KEGG" id="sco:SCO5330"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5415"/>
    <dbReference type="eggNOG" id="COG3440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899921_0_0_11"/>
    <dbReference type="OMA" id="NIMPACL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB45594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="32419" checksum="0028A785772D158C" modified="1999-11-01" version="1">MPKTAHIYVPSPSRENLEIGLDQGLWGWRRSALDRAGTRQAVQSLTEGDFLVLGHRGPNSRVAPGGWANATLQRVIVTQVSRPYFTDSTPVWPGDDYPERIGIDVLEEEQNVPGTALGTDAMEALRLSANKQGAAVLQPGIAAVAQLADVLPLVPVLPGDATVDHEGTDSAVAQVLVRREQVKLRKNLLGGATEAACALCGRVLPTRFIRAAHIKRRSAASRQERLMMANIMPACLIGCDELFEHGYLYVTDNGTIAVSPKSNATPDLAVAAKALEGRTVADYGPHRAPFYIWHRTHIAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ9</accession>
    <name>NUOF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber>7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>NADH dehydrogenase I subunit F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>NDH-1 subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nuoF</name>
        <name type="ordered locus">SCO4567</name>
        <name type="ORF">SCD16A.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34619">
        <property type="entry name" value="T34619"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628729.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974379.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAQ9"/>
    <dbReference type="SMR" id="Q9XAQ9"/>
    <dbReference type="STRING" id="100226.SCO4567"/>
    <dbReference type="GeneID" id="1100007"/>
    <dbReference type="KEGG" id="sco:SCO4567"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4639"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_11"/>
    <dbReference type="InParanoid" id="Q9XAQ9"/>
    <dbReference type="OMA" id="CDDVIMD"/>
    <dbReference type="PhylomeDB" id="Q9XAQ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <feature type="chain" id="PRO_0000118581" description="NADH-quinone oxidoreductase subunit F">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="449" mass="48849" checksum="9D0CDE00E89988E5" modified="1999-11-01" version="1">MMTVAAEIRGSNPEKLLAPVLSAFWDEDESWTLDVYRRHEGYEGLRKALAMAPDDLIAYVKESGLRGRGGAGFPTGMKWQFIPQGDGKPHYLVVNADESEPGTCKDIPLLFANPHSLIEGIVIACYAIRSSHAFIYLRGEVVPVLRRLHEAVREAYAAGFLGENILGSGLDLTLTVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYACPTVVNNVESIASVPAILNKGKDWFRSMGSEKSPGFTLYSLSGHVAGPGQYEAPLGITLRQLLDMSGGMRPGHRLKFWTPGGSSTPMFTDEHLDVPLDYEGVGAAGSMLGTKALQCFDETTCVVRAVTRWTEFYAHESCGKCTPCREGTYWLVQLLRDIEAGKGQMSDLDKLNDIADNINGKSFCALGDGAASPIFSSLKYFREEYEEHITGRGCPFDPAKSTAWADRTEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z561</accession>
    <name>Q9Z561_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5518</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35834">
        <property type="entry name" value="T35834"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629653.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973478.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5518"/>
    <dbReference type="GeneID" id="1100958"/>
    <dbReference type="KEGG" id="sco:SCO5518"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5605"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_7_2_11"/>
    <dbReference type="InParanoid" id="Q9Z561"/>
    <dbReference type="OMA" id="ALCTVPW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB37594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="415" mass="43827" checksum="FB7441A3AC85EE7B" modified="1999-05-01" version="1">MRQNARVTSDSRGSAGTGGTRGDYQELVDELSELLGAPATLENRDFELIAFGAYDSEGDLDPSALDPVRTRSILTRRSTAAVRAWFESFGITRATGPVRIPPTPEAGVYRGRTCLPVRHRGVVLGYVWLLDTDPGPTERQLAAAMEVTGRIGALLADEAQHGADLSRELRAVLTAERDWQRDMAVAELRSALGARAETPHAVVCVAPWPSADPDDAPSVRTVPGATALCTVPWGVSAVSLALLVRLRSAEVQTPATSAAGRLLERAGALGVGGPSGAAGGVAAGVSAPRTGLADLGAAWSEASAAARAARAEERFGPVAQWTSIGAFRLLTSLPPRSADDPAVRALLSPAHRELARTAEVYLDCAGQAGRTAAELGVHRQTLYYRLSRVEQLTGLDLDDGEDRLLLHMALKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O50527</accession>
    <name>O50527_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35889">
        <property type="entry name" value="T35889"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629976.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973167.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101295"/>
    <dbReference type="KEGG" id="sco:SCO5853"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5952"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069623_2_0_11"/>
    <dbReference type="InParanoid" id="O50527"/>
    <dbReference type="OMA" id="PRDRGPH"/>
    <dbReference type="PhylomeDB" id="O50527"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="150"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA15810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="28302" checksum="C8EA4337D6C6F18B" modified="1998-06-01" version="1">MTDARGSDGRIGETNARRAPGTPCWVSLMVHGPAATHDFYGALFGWEFRPGPQQLGPYARALLDGREVAGIGQLPPDRQLPTAWTPYFASDDVNRTAETVRLCGGTVGVGPLDAGEAGRMALGSDPAGAVFGVWQAAAHLGTAVTGRPGTPAWNELLTYEAAGVAKFYETVFGFELLPDPSADRDYVTLRIEGRPVAGIHGVGDALPRDRGPHWTTYFEVADTDESAARLVDLGGHVLAPAHDTPHGRVATVADPEGARFTLLHAQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O54101</accession>
    <name>MMPLB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative membrane protein SCO5905</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5905</name>
        <name type="ORF">SC10A5.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34577">
        <property type="entry name" value="T34577"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630023.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030524.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54101"/>
    <dbReference type="SMR" id="O54101"/>
    <dbReference type="STRING" id="100226.SCO5905"/>
    <dbReference type="PRIDE" id="O54101"/>
    <dbReference type="GeneID" id="1101347"/>
    <dbReference type="KEGG" id="sco:SCO5905"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6003"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_4_0_11"/>
    <dbReference type="InParanoid" id="O54101"/>
    <dbReference type="OMA" id="TIAFEIW"/>
    <dbReference type="PhylomeDB" id="O54101"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000103582" description="Putative membrane protein SCO5905">
        <location>
            <begin position="1"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="847" mass="88617" checksum="E2A443F5C74AE1DE" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O69839</accession>
    <name>O69839_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative iron-sulfur binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6051</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA18985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34689">
        <property type="entry name" value="T34689"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630161.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6051"/>
    <dbReference type="GeneID" id="1101492"/>
    <dbReference type="KEGG" id="sco:SCO6051"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6152"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_15_1_11"/>
    <dbReference type="InParanoid" id="O69839"/>
    <dbReference type="OMA" id="TAMIQHE"/>
    <dbReference type="PhylomeDB" id="O69839"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038010">
        <property type="entry name" value="YhfW_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="428"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="513" mass="54932" checksum="06F0987279C9F4AF" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O69927</accession>
    <name>O69927_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative IS1648 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.01</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34890">
        <property type="entry name" value="T34890"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639744.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039579.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095046"/>
    <dbReference type="KEGG" id="sco:SCP2.01"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8296"/>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="InParanoid" id="O69927"/>
    <dbReference type="PhylomeDB" id="O69927"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="15815" checksum="87ECB45B26A77B51" modified="1998-08-01" version="1">MGRGDLTNREWSLLEPHLPPLGGRGGRWNDHRTVVNGILFRVRTGVPWRDLPERYGSWKTIYERHRRWSADGTWDRILQSVQADADLAGRIDWSMVGVDSTSCRAHQHAAGARKTRPRVPKKGQRPGTTAPTRDSDGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O86548</accession>
    <name>O86548_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6614</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29120">
        <property type="entry name" value="T29120"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630691.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031042.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6614"/>
    <dbReference type="GeneID" id="1102053"/>
    <dbReference type="KEGG" id="sco:SCO6614"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6721"/>
    <dbReference type="eggNOG" id="ENOG5032DTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749890_0_0_11"/>
    <dbReference type="OMA" id="ERYERNT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="369" mass="39663" checksum="8C50A4C2922D6E13" modified="1998-11-01" version="1">MTTTASPDGTPEPRSDDEGAPAEPTGQHPDADGDTPPPPADPAPSAPQPSANGGGRPDESFEALVSDVLGVDPEASRRKKLRWLFVKAAVGLLGVLGAVLVAYLMIKPSTIRENDTNTGIDAAKTPFTVSVRPEEGEPPTWAMVLDRELTADETRKLTTGDPGSAFSYLRELGGRPLVYASVMEHAPERYERNTRDGGLELTDAFKMTVLSTRSSAVVIDGWKTTGITCHKSTTQTVVAMPPQGGATYQGIRLHLPPRAEEPVLTDDAEGQGESYFGTHYIEVGGGQPSGGLRVEAIAPRGQACEWGIKVHYNDSYQKGEWLQLKDAKGKPLRIRTESVPADLRQKWVFASVAWTPCHKNPEGSLCDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O86680</accession>
    <name>O86680_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6633</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35042">
        <property type="entry name" value="T35042"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031059.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6633"/>
    <dbReference type="GeneID" id="1102072"/>
    <dbReference type="KEGG" id="sco:SCO6633"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6739"/>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430155_0_0_11"/>
    <dbReference type="InParanoid" id="O86680"/>
    <dbReference type="OMA" id="RESAPHA"/>
    <dbReference type="PhylomeDB" id="O86680"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="61"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="636" mass="70246" checksum="9E3DE7443B515F58" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>P66301</accession>
    <accession>O86772</accession>
    <name>RL361_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ1</name>
        <name type="synonym">rpmJ</name>
        <name type="ordered locus">SCO4726</name>
        <name type="ORF">SC6G4.04</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35555">
        <property type="entry name" value="T35555"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628884.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974245.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P66301"/>
    <dbReference type="SMR" id="P66301"/>
    <dbReference type="STRING" id="100226.SCO4726"/>
    <dbReference type="GeneID" id="1100167"/>
    <dbReference type="KEGG" id="sco:SCO4726"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4797"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_11"/>
    <dbReference type="InParanoid" id="P66301"/>
    <dbReference type="PhylomeDB" id="P66301"/>
    <dbReference type="PRO" id="PR:P66301"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000126266" description="50S ribosomal protein L36 1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4401" checksum="C19DC4355BFEE26F" modified="2004-10-11" version="1">MKVKPSVKKICDKCRVIRRHGRVMVICDNPRHKQRQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q05562</accession>
    <name>GRPE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">SCO3670</name>
        <name type="ORF">SCH44.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="DNA Seq." volume="6" first="179" last="184">
            <title>Cloning and sequencing of the dnaK locus in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Brans A."/>
                <person name="Loriaux A."/>
                <person name="Joris B."/>
                <person name="Dusart J."/>
            </authorList>
            <dbReference type="PubMed" id="8722574"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1993" name="Gene" volume="130" first="141" last="144">
            <title>Cloning and sequencing of the dnaK region of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bucca G."/>
                <person name="Smith C.P."/>
                <person name="Alberti M."/>
                <person name="Seidita G."/>
                <person name="Passantino R."/>
                <person name="Puglia A.M."/>
            </authorList>
            <dbReference type="PubMed" id="8344522"/>
            <dbReference type="DOI" id="10.1016/0378-1119(93)90358-A"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-166</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="X77458">
        <property type="protein sequence ID" value="CAA54607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L46700">
        <property type="protein sequence ID" value="AAB29452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB91161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S41947">
        <property type="entry name" value="PN0643"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975269.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q05562"/>
    <dbReference type="SMR" id="Q05562"/>
    <dbReference type="STRING" id="100226.SCO3670"/>
    <dbReference type="GeneID" id="1099106"/>
    <dbReference type="KEGG" id="sco:SCO3670"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3728"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_4_2_11"/>
    <dbReference type="InParanoid" id="Q05562"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="PhylomeDB" id="Q05562"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000113869" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="225" mass="23874" checksum="7F61F78C4FB3FA9E" modified="1995-02-01" version="2">MTEETPGFEEKPDVPSGATPDDAEPQAASEEGAAPAGDASENAGLVAQLDQVRTALNERTADLQRLQAEYQNYRRRVERDRVAVKEVAVANLLSELLPVLDDVGRAREHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAEPQPGAQTVKPAEDAAEAQDSSGAEDDAGTKESGGPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX8</accession>
    <name>Q8CJX8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ordered locus">SCO3060</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733591.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975751.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3060"/>
    <dbReference type="GeneID" id="1098493"/>
    <dbReference type="KEGG" id="sco:SCO3060"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3120"/>
    <dbReference type="eggNOG" id="COG0026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_2_11"/>
    <dbReference type="InParanoid" id="Q8CJX8"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="PhylomeDB" id="Q8CJX8"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="134"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="295"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="411" mass="44439" checksum="53C2312A24551D48" modified="2003-03-01" version="1">MRPATGGGRGRKRPVNRWAPRGRYARGVTFPVVGMVGGGQLARMTHEAGIPLGIRFKLLSDTPQDSAAQVVNEVVVGDYRDLDTLREFARGCDVITFDHEHVPTEHLKALEADGIPVRPGPEALVHAQDKGVMRAKLDAIGVPCPRHRIVRDPADVAAFAAEGAVEGGDGFPVVLKTVRGGYDGKGVWVVDSVAEAAEPFRAGVPVLAEEKVDFVRELAANVVRSPHGQAVAYPVVESQQVKGVCDTVIAPAPDLDEALALRAEEMALGIAKELGVVGHLAVELFQTRDGRVLVNELAMRPHNSGHWTMDGAITSQFANHVRAVLDLPLGDPRPRAKWTVMVNVLGGDYPDMYSAYLHCMARDPQLKIHMYGKDVKPGRKVGHVNTYGDDLDDVLERARHAAGYLRGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWC4</accession>
    <name>Q8VWC4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.38c</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639811.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039604.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095074"/>
    <dbReference type="KEGG" id="sco:SCP2.38c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8330"/>
    <dbReference type="HOGENOM" id="CLU_1874203_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="15094" checksum="2A213C5CBE0C999D" modified="2002-03-01" version="1">MPVEGFNPERDLTAPSLYSLNLSAAQHCTLAWVEDHGGLFDVIPVPVETVAEDCGNSVSTVHEALARLEALNLLVRTSAGLYRINARYYFTLHPELREMITAALTDPPVTPDDRARAPRKVSNTDARRRRTIRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J30</accession>
    <name>Q93J30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative protease (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3977</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628160.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029350.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3977"/>
    <dbReference type="GeneID" id="1099413"/>
    <dbReference type="KEGG" id="sco:SCO3977"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4051"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_3_7_11"/>
    <dbReference type="InParanoid" id="Q93J30"/>
    <dbReference type="OMA" id="EIWTHKP"/>
    <dbReference type="PhylomeDB" id="Q93J30"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="424"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="519" mass="50327" checksum="5CB8D5F0CC19E428" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J46</accession>
    <name>Q93J46_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3057</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC44522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627278.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028741.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3057"/>
    <dbReference type="MEROPS" id="M19.004"/>
    <dbReference type="GeneID" id="1098490"/>
    <dbReference type="KEGG" id="sco:SCO3057"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3117"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_3_1_11"/>
    <dbReference type="InParanoid" id="Q93J46"/>
    <dbReference type="OMA" id="TWGNVQR"/>
    <dbReference type="PhylomeDB" id="Q93J46"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="376" mass="39533" checksum="52D2E2FF7494621B" modified="2001-12-01" version="1">MADLQDDLHTGTEAGGLDDLPVPLAAEAFPPEPYAPVSDPDDEPLARAHAVLAAHPVADGCNGLPWALRHLPWYDLELGESAVDTDVPRLREGHVGALLWSLHLPESLDGDRAVGATLEQLDLVKTVVRAHPEGLRLAYDAGQAIDARNCGRIAVLPGPAGAAALGDRLGILRSLHALGLRVLTLSGVSWASEAGLTRFGEEVVREMNRLGVVADLSGASAETVRRTFAVSKAPALCTRSAARALRPHPANLPDDLLVELGAAGGLCMVPLTAEQTGPTVRDVADHLDHVRTVAGPQSVGLSGTYDSGAAHPLELGDPSCYPRLVAELLRRGWDEADVALLTWGNVQRVLRAAAFTAKAAQLRREPSTATIADLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA1</accession>
    <name>Q93JA1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7496</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631542.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031704.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102934"/>
    <dbReference type="KEGG" id="sco:SCO7496"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7609"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_6_1_11"/>
    <dbReference type="InParanoid" id="Q93JA1"/>
    <dbReference type="OMA" id="AVMIFNA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC44674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="28121" checksum="5AE2E17479F1A9F8" modified="2001-12-01" version="1">MVPGIGCGRRRRAGGVACVDVVALLGIGLLTGVTTVLFGFGGGFVAVPVVVWTDSALGADAIRVATATSALVMVVNAAFATAVTPRRVLAALRGGGPLLVLLGVGAAAGALAARHAPAGLIRWAFVAYVALTVVDLLLRPGFLRPRAPAEAAPGTPRPLPAAVGAPVGAVAAFLGVGGSVMTVPAMRRAGHTMHVATALANPLTLAIALPAAAVFLGGSGDPAGAHPHLALVGLVDLRAAGALLLGALPVIAVLRRRPPHIPDRLYAWTYVALLAAVAVAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ6</accession>
    <name>Q93JJ6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973979.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4998"/>
    <dbReference type="GeneID" id="1100439"/>
    <dbReference type="KEGG" id="sco:SCO4998"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5079"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_3_11"/>
    <dbReference type="OMA" id="RTLACNC"/>
    <dbReference type="PhylomeDB" id="Q93JJ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="31329" checksum="60CE12A0E0796A86" modified="2001-12-01" version="1">MPPRTTPTERQRRLGAELRKMRTAAGITADQAAGLLGLDRAKVSNIETGIRTISPERLRTLACNCDCSDEAYVEALVRMARPGARGWWERYRGSLSAGLLDIAEFEAQATRMRTIHIAHIPGLLQTSDHALELFRAVLPLLPEHEVALRLAYRVERQRVLEGDDPPEYVAVVHEAAVRMQFGGPTVARAQLEHLVAVSERPTVRLLVVPFTAGAFPGSGQIFNYLEGPVPQLDTVQIDSTHGPEFLSGEAQLAKYRTHLDRMERIALSPQASRDFIRDVANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK2</accession>
    <name>Q93JK2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4992</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629144.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973985.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4992"/>
    <dbReference type="GeneID" id="1100433"/>
    <dbReference type="KEGG" id="sco:SCO4992"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5073"/>
    <dbReference type="eggNOG" id="ENOG5033ZT4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079633_0_0_11"/>
    <dbReference type="OMA" id="TPDRRWY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="23290" checksum="B53D7281DE32D3A0" modified="2001-12-01" version="1">MEQRRGSTSQPLEGAGFDPAFIPGLTAPVSGEPEDVRRAEDEAEKDADAETEESSHSPAADEPPAEDAEDAEEPDAEAPVDGPVFEASDRRAKIVADHRGVRLSLDDQACEFRWDEVGAVETETGRFGKRFTVTVHTPDRRWYPIEIEAASRSRFAEWESALDEVLDAYFEDGEAESETEAEAVEAAETADTADTAEKDAEDAEGAEEAKARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD21</accession>
    <name>Q9AD21_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.129</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639702.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039428.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095207"/>
    <dbReference type="KEGG" id="sco:SCP1.129"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8078"/>
    <dbReference type="HOGENOM" id="CLU_1785741_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15470" checksum="1E2070D2C01E212F" modified="2001-06-01" version="1">MAQVTITDLLRVIAAVPGWRERGSNGVRLVYDRNCLKLSTIDRPDEILARARASGHTTAAWELTMYATSLPGVRVWLSSLDGEHLVDVSPFWADTPTLVVFTTTGGQMAFPVIDCPTARSSGKAATAGHATGGSAAVSKREGTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD35</accession>
    <name>Q9AD35_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4Fe-4S Wbl-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.115</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639688.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039414.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095193"/>
    <dbReference type="KEGG" id="sco:SCP1.115"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8064"/>
    <dbReference type="HOGENOM" id="CLU_1531664_0_0_11"/>
    <dbReference type="OMA" id="CLKWALA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="175" mass="19591" checksum="D33614719D9CE055" modified="2001-06-01" version="1">MTRTGAPHPSHFTHPDPRFPFPHSPVPTPCQTQPDTFDFVNGDRSGESRQSTEQRLARARRACSGCPIVKDCLRWALVNKPLTKVGIFAATTPGQRTELRKRIADRLGPDWIDVLADQDKDRRERAAAARHDPLTVNQSRIVRLDREVNGPMRAPLTPSQQERNLSRLMAGLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD61</accession>
    <name>Q9AD61_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.89c</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639662.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039388.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095167"/>
    <dbReference type="KEGG" id="sco:SCP1.89c"/>
    <dbReference type="HOGENOM" id="CLU_709623_0_0_11"/>
    <dbReference type="OMA" id="ELALWRY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="389" mass="42801" checksum="B27057143383AA27" modified="2001-06-01" version="1">MIAVDRWTGEEALLLRSVMRASVREFAGRLGISPRTVSNWQRNKTSICRPQMAQILDTALLQCTPAEQEAFSLRLAALRGTSAPLTAESAALPAPCTVVSHKFLPVYLGECSAPLYAAGSPGEPGPGGLERRVLPADHHSAQSSTVHMYACGVAVVHLEEHHRLETLTELALWRYRTYLKEPGWVGEWMAHLLARHGDDKDHPAQSLVPQYVLSAYELRTHSWSSAGLDTALQLLATPSVLVNRQNPADVVPLGPGVEEIKFRDGWAHPEAVTFDGGVSRGVVGWSGVAYHPQSDERALTMSQIVALELDVQALWALSSHVLHVVEDGQDPVMPRAYGWRFLRSAYFRLTTARPTETAQHRVMREAILATSELPDRLRAAQDALRDSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD82</accession>
    <name>Q9AD82_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO4916</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629069.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029947.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4916"/>
    <dbReference type="GeneID" id="1100357"/>
    <dbReference type="KEGG" id="sco:SCO4916"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4995"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_2_11"/>
    <dbReference type="InParanoid" id="Q9AD82"/>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="PhylomeDB" id="Q9AD82"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="48"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="220"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="321"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="461"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD30907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="549" mass="58095" checksum="2B2478530E9EDB67" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD92</accession>
    <name>CHPH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chaplin-H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">chpH</name>
        <name type="ordered locus">SCO1675</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1714" last="1726">
            <title>A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Rink R."/>
                <person name="de Jong W."/>
                <person name="Siebring J."/>
                <person name="de Vreugd P."/>
                <person name="Boersma F.G."/>
                <person name="Dijkhuizen L."/>
                <person name="Wosten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="12832396"/>
            <dbReference type="DOI" id="10.1101/gad.264303"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1727" last="1740">
            <title>The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Elliot M.A."/>
                <person name="Karoonuthaisiri N."/>
                <person name="Huang J."/>
                <person name="Bibb M.J."/>
                <person name="Cohen S.N."/>
                <person name="Kao C.M."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12832397"/>
            <dbReference type="DOI" id="10.1101/gad.264403"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="433" last="443">
            <title>The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Stokroos I."/>
                <person name="Deelstra H.J."/>
                <person name="Penninga N.A."/>
                <person name="Bormann C."/>
                <person name="Salas J.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Woesten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="15228525"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04143.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="64" first="602" last="613">
            <title>SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Capstick D.S."/>
                <person name="Willey J.M."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="17462011"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2007.05674.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="5879" last="5889">
            <title>Function and redundancy of the chaplin cell surface proteins in aerial hypha formation, rodlet assembly, and viability in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Di Berardo C."/>
                <person name="Capstick D.S."/>
                <person name="Bibb M.J."/>
                <person name="Findlay K.C."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="18586935"/>
            <dbReference type="DOI" id="10.1128/JB.00685-08"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CREATION OF A MINIMAL CHAPLIN STRAIN</scope>
        <scope>MUTAGENESIS OF CYS-56 AND CYS-74</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="1128" last="1140">
            <title>Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose.</title>
            <authorList>
                <person name="de Jong W."/>
                <person name="Woesten H.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Claessen D."/>
            </authorList>
            <dbReference type="PubMed" id="19682261"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06838.x"/>
        </citation>
        <scope>FUNCTION IN GROWTH SUBSTRATE ATTACHMENT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E18839" last="E18839">
            <title>The assembly of individual chaplin peptides from Streptomyces coelicolor into functional amyloid fibrils.</title>
            <authorList>
                <person name="Sawyer E.B."/>
                <person name="Claessen D."/>
                <person name="Haas M."/>
                <person name="Hurgobin B."/>
                <person name="Gras S.L."/>
            </authorList>
            <dbReference type="PubMed" id="21526199"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0018839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISULFIDE BOND</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="9821" last="9826">
            <title>Dual amyloid domains promote differential functioning of the chaplin proteins during Streptomyces aerial morphogenesis.</title>
            <authorList>
                <person name="Capstick D.S."/>
                <person name="Jomaa A."/>
                <person name="Hanke C."/>
                <person name="Ortega J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="21628577"/>
            <dbReference type="DOI" id="10.1073/pnas.1018715108"/>
        </citation>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 30-GLN--VAL-51; 62-VAL--LEU-66 AND VAL-62</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2013" name="J. Struct. Biol." volume="184" first="301" last="309">
            <title>Chaplins of Streptomyces coelicolor self-assemble into two distinct functional amyloids.</title>
            <authorList>
                <person name="Bokhove M."/>
                <person name="Claessen D."/>
                <person name="de Jong W."/>
                <person name="Dijkhuizen L."/>
                <person name="Boekema E.J."/>
                <person name="Oostergetel G.T."/>
            </authorList>
            <dbReference type="PubMed" id="24012833"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2013.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="4491" last="4501">
            <title>Surface modification using interfacial assembly of the Streptomyces chaplin proteins.</title>
            <authorList>
                <person name="Ekkers D.M."/>
                <person name="Claessen D."/>
                <person name="Galli F."/>
                <person name="Stamhuis E."/>
            </authorList>
            <dbReference type="PubMed" id="24413917"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5463-z"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4 5 6 7 8 9 11">One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins (PubMed:12832396, PubMed:12832397, PubMed:15228525, PubMed:17462011). Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation (PubMed:17462011). Chaplins are also involved in cell attachment to a hydrophobic surface (PubMed:19682261). Forms amyloid fibrils in vitro probably composed of stacked beta-sheets (PubMed:21526199). A small chaplin extract (ChpD, ChpE, ChpF, ChpG and ChpH) self-assembles into 2 different amyloids; small fibrils at the air-water interface form an amphipathic membrane that resembles spore-surface structures involved in aerial hyphae formation, and hydrophilic fibrils in solution that resemble the fibers that attach cells to a hydrophobic surface. At the air-water interface the hydrophilic surface is in contact with water (probably equivalent to the peptidoglycan layer), while the hydrophobic face is exposed to the air, making the surface of the aerial hyphae hydrophobic (PubMed:24012833). A minimal chaplin strain capable of forming aerial mycelium/hyphae on minimal medium contains ChpC, ChpE and ChpH. The strain also has restored rodlet formation on the hyphae surface (PubMed:18586935). A small chaplin extract applied to a chaplin-deficient strain restores aerial hyphae formation (PubMed:12832396, PubMed:12832397). The small chaplin extract forms an amyloid-like structure similar to that seen on the surface of cells without rodlets (rdlA-rdlB deletions), and is highly surface active, reducing surface tension from 72 to 26 mJ/m(2), which probably allows escape of hyphae from an aqueous environment into air (PubMed:12832396).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer; disulfide linked. About 10% of ChpH isolated from cell wall forms disulfide-bonded homodimers.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-15929047">
            <id>Q9AD92</id>
        </interactant>
        <interactant intactId="EBI-15929047">
            <id>Q9AD92</id>
            <label>chpH</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4 15">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 4 9 10">Secreted</location>
            <location evidence="3 4 9 10">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Fimbrium</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3 4 6">Present in aerial hyphae of sporulating cultures (at protein level) (PubMed:12832396, PubMed:17462011). Strongest expression in spores, with weaker expression in aerial hyphae (PubMed:12832397).</text>
    </comment>
    <comment type="induction">
        <text evidence="3 4 6">Highly expressed in 24 hour cultures while still submerged, during aerial hyphae formation on minimal medium, decreases once aerial growth ceases. Strongly expressed in aerial hyphae (at protein level) (PubMed:12832396). During aerial hyphae formation and sporulation on rich medium, under control of ECF sigma factor BldN; more strongly expressed when sporulation is blocked by deletion of whiB, whiD or whiH (PubMed:12832397). Expression depends on bldB but not bldA, bldD or bldH (at protein level) (PubMed:17462011).</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Has 2 domains capable of forming beta amyloid structures, both of which are required for aerial hyphae formation while the N-terminal region is not required for rodlet formation.</text>
    </comment>
    <comment type="mass spectrometry" mass="5122.0" method="MALDI" evidence="3"/>
    <comment type="mass spectrometry" mass="5116.61" method="MALDI" evidence="4"/>
    <comment type="disruption phenotype">
        <text evidence="3 4 5 6 8">A single chpH disruption and double chpC-chpH knockout have no visible or sporulation phenotype; a quadruple chpA-chpC-chpD-chpH knockout has delayed aerial hyphae formation and sporulation. A quintuple chpA-chpB-chpC-chpD-chpH knockout has a longer delay in aerial hyphae formation and an almost complete lack of sporulation. The quintuple knockout still expresses ChpE, ChpF and ChpG (PubMed:12832397). Quintuple knockout chpA-chpB-chpC-chpD-chpH has strongly delayed aerial hyphae formation, makes many fewer aerial hyphae but no effect on viability of the spores produced. Further deletion of chpE leads to more severe effects, and on rich media few aerial hyphae are produced after prolonged growth. Those few hyphae do differentiate into spores and have a rodlet layer (PubMed:12832396). Deletion of all 8 chaplin genes on minimal medium leads to severely disrupted aerial hyphae that collapse on the colony surface and are not hydrophobic. A few spore chains can still be made, but they have neither rodlets or amyloid-like fibers. rdlA and rdlB mRNA are down-regulated (PubMed:15228525, PubMed:17462011). Deletion of all 8 chaplin genes on rich medium leads to a reduced abundance of aerial hyphae without rodlets and occasional spore chains on surface hyphae. A complete chaplin-negative plus ram-negative strain (deletion of ramR or the ramC-ramS-ramA-ramB operon) leads to the complete loss of robust aerial hyphae (PubMed:17462011). Deletion of all 8 chaplin genes significantly reduces cellular attachment to a hydrophobic substrate; thin fibrils instead of fimbrae are detected. The long chaplins (ChpA, ChpB and ChpC, as seen by near wild-type attachment of the hextuple chpA-chpB-chpC-chpD-chpE-chpH knockout) are not essential but may contribute to attachment (PubMed:19682261).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="12">The small chaplin mixture (a cell wall extract of an rdlA-rdlB knockout) forms a stable coat on a number of surfaces (including Teflon and cotton) and emulsifies oil-water mixtures, which could be useful in medical and technical applications.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the chaplin family. Short chaplin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625950.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977150.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9AD92"/>
    <dbReference type="DIP" id="DIP-60401N"/>
    <dbReference type="STRING" id="100226.SCO1675"/>
    <dbReference type="DNASU" id="1097106"/>
    <dbReference type="GeneID" id="1097106"/>
    <dbReference type="KEGG" id="sco:SCO1675"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1692"/>
    <dbReference type="eggNOG" id="ENOG50348JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145456_3_1_11"/>
    <dbReference type="OMA" id="VHSPGVV"/>
    <dbReference type="PhylomeDB" id="Q9AD92"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="IntAct"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0034">Amyloid</keyword>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0281">Fimbrium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3 4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323940" description="Chaplin-H" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="2">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Forms amyloid fibrils in vitro" evidence="10">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Forms amyloid fibrils in vitro" evidence="10">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14 16">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Very decreased formation of aerial hyphae, no spore chains formed, no effect on rodlet formation." evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="In minimal chaplin strain, forms very sparse aerial hyphae, no rodlets form; when associated with G-74, loss of disulfide bond." evidence="7">
        <original>C</original>
        <variation>V</variation>
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Severely reduced ability to form amyloid fibers in vitro, very decreased formation of aerial hyphae, very few rodlets, no spore chains formed." evidence="10">
        <original>VIGLL</original>
        <variation>AAAAA</variation>
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Significantly reduced ability to form amyloid fibers in vitro, decreased formation of aerial hyphae and rodlets, no change in spore chain formation." evidence="10">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="In minimal chaplin strain, forms very sparse aerial hyphae, no rodlets form; when associated with V-56, loss of disulfide bond." evidence="7">
        <original>C</original>
        <variation>G</variation>
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15228525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="18586935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="19682261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="21628577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="24012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="12">
        <source>
            <dbReference type="PubMed" id="24413917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="13">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="16">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="7345" checksum="34FAD03DBE797735" modified="2001-06-01" version="1" precursor="true">MLKKVVAAAAATGGLVLAGAGMAVADSGAQGAAVHSPGVLSGNVVQVPVHVPVNVCGNTISVIGLLNPAFGNVCINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK34</accession>
    <name>Q9AK34_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4892</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629045.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029930.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4892"/>
    <dbReference type="GeneID" id="1100333"/>
    <dbReference type="KEGG" id="sco:SCO4892"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4972"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063235_1_0_11"/>
    <dbReference type="OMA" id="PSFFCRR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="261"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="35541" checksum="349E27D50008E323" modified="2001-06-01" version="1">MVYRIHFTLEDLARTRVAEPPPLLELSAALRTLRERGHPVRFGAWRHAVRDALDPRARMVLELVPPGGWAPTFLTSSAHGSAQELLERVRATPRAVVRADLAHVAEWQPLPRWAHRLPDDAALLGRLCDALEHVHAVLLAPYWAHVTAVAGTDRGLRTRQAIGGGMDRMLASLHPRRIRWNPPVLEIAMLSGLDGDLHLGGRGLLLVPSVFGAAAPAVDIDAEPQPVLRYPTGTEQSPGPLPGAAAPPGSVPGRARSPLASLLGRTRAAVLSAIAENPGCSTKELAALLGIAPPSASEHATTLREARLIDTVRDRNTVLHSPTALGITLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWQ1</accession>
    <name>Q9EWQ1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7676</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971465.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7676"/>
    <dbReference type="GeneID" id="1103114"/>
    <dbReference type="KEGG" id="sco:SCO7676"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7795"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_0_11"/>
    <dbReference type="InParanoid" id="Q9EWQ1"/>
    <dbReference type="OMA" id="GAGMCVM"/>
    <dbReference type="PhylomeDB" id="Q9EWQ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC17493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7430" checksum="CF0939433EE20CB5" modified="2001-03-01" version="1">MTLAGQAFGSGRVGAERDRCVGAGQCVLAAPGVFDQDEEDGLVRVLAERPSAAESDAVRAAVRACPSGALTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="149" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWY9</accession>
    <name>Q9EWY9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO1137</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625430.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027601.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1137"/>
    <dbReference type="GeneID" id="1096560"/>
    <dbReference type="KEGG" id="sco:SCO1137"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1134"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_11_1_11"/>
    <dbReference type="InParanoid" id="Q9EWY9"/>
    <dbReference type="OMA" id="QNGFITM"/>
    <dbReference type="PhylomeDB" id="Q9EWY9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="341"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="548" mass="58277" checksum="72F37F817FD5D8E9" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX04</accession>
    <name>Q9EX04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1122</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625415.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027589.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1122"/>
    <dbReference type="GeneID" id="1096545"/>
    <dbReference type="KEGG" id="sco:SCO1122"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1119"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_3_0_11"/>
    <dbReference type="OMA" id="RLHHRKD"/>
    <dbReference type="PhylomeDB" id="Q9EX04"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="28940" checksum="BDF71653727C4ED4" modified="2001-03-01" version="1">MTGSEAPPSFRLAYVPGVTPDKWVRIWNERLPDVPLVLTQVPAAEAAGVLLGGDADAGLVRLPVDRTALSAIPLYTETTVVLVPKDHLVTAADEVSVGDIAEEIVLHPLDDVLDWERLPGRPALERPATTADAVELVAAGIGVLLVPLSLARLHHRKDLTYRTVTDAPESSVALSWPEDAHTDRVEDFIGIVRGRTVNSTRGRQPEPVRSKGGRAEGAPSTRGKPAAGKAGGRTGGAAGGKTGGKQTGSARRGTGGSHRGASGGKGKGSGRGGRPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2P5</accession>
    <name>Q9F2P5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028769.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3105"/>
    <dbReference type="GeneID" id="1098539"/>
    <dbReference type="KEGG" id="sco:SCO3105"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3168"/>
    <dbReference type="eggNOG" id="ENOG5031H1Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618089_0_0_11"/>
    <dbReference type="OMA" id="TGPAKLI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC09546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="20583" checksum="2AABABEA5F5A976F" modified="2001-03-01" version="1">MLTRFTSSGLIDPSDRPKRRASVHGRRSVSGERTDDMGMKTKIALGAVVGIAVIGALSANAGDGDGGAKSDDRTSASAGEKQDGAGADGAKTDGASEAKPAEDKAAEKASQAEQFKAFVQKNGTPKEKDAVSHVTKVQGADEQNDILDAADVYTDFTGGIMGSGTGPAKLIASAFADWKDSENGLVTIYDADGELLGNGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F313</accession>
    <name>Q9F313_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2621</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAC09997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626857.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976178.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2621"/>
    <dbReference type="GeneID" id="1098055"/>
    <dbReference type="KEGG" id="sco:SCO2621"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2667"/>
    <dbReference type="eggNOG" id="ENOG502ZQDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193873_1_0_11"/>
    <dbReference type="OMA" id="RFMNSIA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC09997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6680" checksum="3C44861B1EC7B4F4" modified="2001-03-01" version="1">MAISLSVVLLLGIILVVLLRGGSIKAGPAVVAVLFGFFLASTGMADDIQRFLDSIADTINSIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F360</accession>
    <name>Q9F360_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2415</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAC12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626660.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028341.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2415"/>
    <dbReference type="GeneID" id="1097849"/>
    <dbReference type="KEGG" id="sco:SCO2415"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2456"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045966_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F360"/>
    <dbReference type="OMA" id="RPGWPTV"/>
    <dbReference type="PhylomeDB" id="Q9F360"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="58"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="143"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="413" mass="42687" checksum="312DF3F56C3CC328" modified="2001-03-01" version="1">MKRATLPRGRVAGLTAGSLAAVGLALALTLGGVSVVPSGFDGIEDLPLPGGADLGDHPYTVTAELQDVLSLVPHSAVRVNDVAVGRITGIELGEDDWSARVTMEINGEVRLPADATARLEQSSLLGEKYVQLVAPAKETGTGRLTDGSVIPLARTSRNTEVEEVFGALSLLLNGGGVNQLKTITRELNAALGGREPEVRSMLKRVNTLVGDLDDHRGDITDALDAVNRLSSTLATRKDDVGTVLTDLSPGLKTLERQRGSLLTMLRSLDTLSGVAVSTINASKDDMIADLKAVAPTLRALADAGTDLPDSLQVLLTYPFTDEVLRGVKGDYLNTYLSMVAVPGTEVIPPLVDGDTPGPTASATAQDGPDPAAKNPAAKNPISRKRSSGQRGSASPLPLPSVSGAGPASGGEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3I2</accession>
    <name>Q9F3I2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2799</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627029.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028592.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2799"/>
    <dbReference type="CAZy" id="CBM2">
        <property type="family name" value="Carbohydrate-Binding Module Family 2"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="1098233"/>
    <dbReference type="KEGG" id="sco:SCO2799"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2857"/>
    <dbReference type="eggNOG" id="COG3469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_4_1_11"/>
    <dbReference type="InParanoid" id="Q9F3I2"/>
    <dbReference type="OMA" id="TPKWGGV"/>
    <dbReference type="PhylomeDB" id="Q9F3I2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176683" evidence="2">
        <location>
            <begin position="38"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="195"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="489" mass="49324" checksum="1E9B412B5FE51CE5" modified="2001-03-01" version="1">MRTHRRKVSGRNKAIGALVAAAVAGGGALLFTSTAQAASVGAAYTKTSEWSTGYTAQYVVTNNSGQTKADWTLEFDLPSGAKLGSLWNAESKADGQHVTVTPPKWDTDGLKAGESVTVGFVVNGTADPTGCLVDAAACSTDDGATPEPGGRPTDPPAPTPTPTPTATDSTEPAPTGTPTPPAPTGTPGDGTAAGAGFAPYVDTSLYPAFDLLAHSAATGVKEYNLAFVTDGGGCTPKWGGVTDLGSDAVANQIGALRAEGGDVRVSFGGASGSELGTTCTSADALAAAYGKVVDAYKLTKVDFDVEGGALPDTAANTRRAQAIAALQKQHPGLDVSFTLPVMPEGLTQAGVDLLADAKENGVGIDAVNIMAMDYGPAYSGDMGTYAEQAATATQAQIKGVLGRSDADAWKTVAVTPMIGVNDVASEVFKVEDATQLVKFAKSKGLGALSMWSATRDKACAGGPKPSADATCSSVDQEPSAFAKALAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3I9</accession>
    <name>Q9F3I9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629422.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030146.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5276"/>
    <dbReference type="GeneID" id="1100717"/>
    <dbReference type="KEGG" id="sco:SCO5276"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5361"/>
    <dbReference type="eggNOG" id="ENOG5033JA1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884647_0_0_11"/>
    <dbReference type="OMA" id="FRWRTAG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="14572" checksum="D163371F87C81ACE" modified="2001-03-01" version="1">MILLGPVPEGADGPIPVEVDAHLDPSTADGLDLVFGDEETRDGAGQRVVRVARDVYTDGLDLARRCAAQAVRRFGELQEGLRPDEIEMQLAIKIDAGVATLVKSGAEAQLQITLRWQTAPASSPAAAPDGQGTGAADGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3J0</accession>
    <name>Q9F3J0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5275</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629421.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030145.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5275"/>
    <dbReference type="GeneID" id="1100716"/>
    <dbReference type="KEGG" id="sco:SCO5275"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5360"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="InParanoid" id="Q9F3J0"/>
    <dbReference type="OMA" id="WDQGRLK"/>
    <dbReference type="PhylomeDB" id="Q9F3J0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="195"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112927" checksum="B7EF02D279F3DB79" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3M8</accession>
    <name>Q9F3M8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7659</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971486.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7659"/>
    <dbReference type="DNASU" id="1103097"/>
    <dbReference type="GeneID" id="1103097"/>
    <dbReference type="KEGG" id="sco:SCO7659"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7778"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F3M8"/>
    <dbReference type="PhylomeDB" id="Q9F3M8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="373" mass="39087" checksum="4B51282502C26F05" modified="2001-03-01" version="1">MHTPVTIIGAGLGGLTLARVLHVHAIPVTVYEADSSPSARAQGGLLDIHDYNGQLAVEAAGLTDEFRAIVLEGRQALRVLDPDGTVRLDRADDGTGGRPEVQRGDLRQILLDSLPAGTVRWGHKVSRARPLGDGRHEVTFADGGTVVTRLLVGADGAWSRVRPLLSSATPEYVGKSVVETYLFDAGTRHPVAAKTVGGGMLIAPAPGKEIFAHREKDDTLHAYVGLSRPLDWFAGIDFTDGAAATARIAREFDGWATELTALITDTDVAPALRALHALPAGHRWERVPGVTLLGDAAHLAAPNGEGANLAMLDGAELGTALAAHPGDVEAALAEYERAMFPRSAEAAGDDMIGMDSPDNTAQGLIDLITENGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3Q7</accession>
    <name>Q9F3Q7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631670.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971514.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7630"/>
    <dbReference type="GeneID" id="1103068"/>
    <dbReference type="KEGG" id="sco:SCO7630"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7749"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_11"/>
    <dbReference type="InParanoid" id="Q9F3Q7"/>
    <dbReference type="OMA" id="HGAAIRM"/>
    <dbReference type="PhylomeDB" id="Q9F3Q7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="23284" checksum="5545E107CDCFA9DE" modified="2001-03-01" version="1">MRLLLIRHGQTPSNLKHLLDTAEPGPGLTALGQEQAAALPGALASEEIGALYASTLVRTQLTAAPLASATGLEVRVRAGIRELTAGDLEMRGDDDAARTYMHTAFAWSAGDVGLRMPGGENGAEALARFDAVVAEAHETGAETVALVSHGAAIRMWVAARADNVDVDYAERHPLANTGIVILSGSPGQGWRALLWEGESLGPVPLTPGPDDPTGATVEQLSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBQ2</accession>
    <name>Q9FBQ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4268</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628440.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029544.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4268"/>
    <dbReference type="GeneID" id="1099708"/>
    <dbReference type="KEGG" id="sco:SCO4268"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4334"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_5_1_11"/>
    <dbReference type="InParanoid" id="Q9FBQ2"/>
    <dbReference type="OMA" id="GARFMDC"/>
    <dbReference type="PhylomeDB" id="Q9FBQ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="27908" checksum="C047B8C3CAE56BF2" modified="2001-03-01" version="1">MPDVTSGRKKGDFRRPERDVSGGVQHVPMARRAAGTAGGRGTATVRAARRPELRLPPLTPYEDDGGLEPDGDYDALDFRETDLTGQDGAGARFMDCALTGCALDEASLRAARLLDTRLTGVRGVGTNLAEATLRDVELLDARLGGTQLHGAVLERVLIRGGKIDYLNLRRARLKDVVFESCVLVEPDFGGARLERVEFVDCALKQADLGAATLVDVDLRGAAPLDLSRGVDRLSGAVISPTQLLDLAPVLAAELGVRVLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBS0</accession>
    <name>Q9FBS0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7172</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971971.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102610"/>
    <dbReference type="KEGG" id="sco:SCO7172"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7272"/>
    <dbReference type="HOGENOM" id="CLU_2620410_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176694" evidence="1">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8234" checksum="7EFAAF804BC5510F" modified="2001-03-01" version="1">MPSLGWKKKLVSASLVALGATGVTLGGAAAAHADTMIGLYDTQAQCLAVKVVYQSGDPGGSYYCDNDHEAGVWYLWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBT4</accession>
    <name>Q9FBT4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7158</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631217.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031469.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7158"/>
    <dbReference type="GeneID" id="1102596"/>
    <dbReference type="KEGG" id="sco:SCO7158"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7259"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_2_11"/>
    <dbReference type="InParanoid" id="Q9FBT4"/>
    <dbReference type="OMA" id="KCIWTEQ"/>
    <dbReference type="PhylomeDB" id="Q9FBT4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="812" mass="88172" checksum="9B676B58A194E211" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBW3</accession>
    <name>LGT2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase 2</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt2</name>
        <name type="ordered locus">SCO7822</name>
        <name type="ORF">SC8E7.19c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631850.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971316.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FBW3"/>
    <dbReference type="SMR" id="Q9FBW3"/>
    <dbReference type="STRING" id="100226.SCO7822"/>
    <dbReference type="GeneID" id="1103260"/>
    <dbReference type="KEGG" id="sco:SCO7822"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7932"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_2_0_11"/>
    <dbReference type="InParanoid" id="Q9FBW3"/>
    <dbReference type="OMA" id="YVDARYF"/>
    <dbReference type="PhylomeDB" id="Q9FBW3"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172686" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase 2">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="317" mass="34397" checksum="C4A518402F91373F" modified="2001-03-01" version="1">MDLAYLPSPSTGVLHLGPIPLRAYAFCIILGVFAAVWLGNRRWVARGGKQGVIADVTLWAVPFGLVGGRLYHVFTSPDAYFGERGEPVRALYVWEGGLGIWGAIALGAVGAWIGCRRHRIPLPAFADAVAPGIVLAQAIGRWGNWFNQELYGRPTTLPWGLEIDRAHRPAGTLDIATYHPTFLYESLWNIGVAALILWAAKRFPLGHGRTFALYVAAYTVGRFGTEYLRIDEAHTFLGLRLNNWTSVLVFLGAVACLVVSAHRHPGIENVARLQGAGADGRTDDPRPADASVGLASGPPGNSTPRRATESWNVRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC86</accession>
    <name>Q9FC86_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631161.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7100"/>
    <dbReference type="ESTHER" id="strco-SC4B10.1">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1102538"/>
    <dbReference type="KEGG" id="sco:SCO7100"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7201"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136343_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC86"/>
    <dbReference type="OMA" id="WGCILTA"/>
    <dbReference type="PhylomeDB" id="Q9FC86"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="29169" checksum="F0F719BED38BD1D0" modified="2001-03-01" version="1">MSPTARDLVPPTKGFTMPAILIHGVPDTHHVWDGVRRRLTRSDVEAWDLPGFGAERPAGFGSTKEEYVDWLVRRLERVGEPVDLVGHDWGCILTLRVASLRPDLVRTWAGGNGPVNAGYVWHPLARIWQDRVQGDRYMAELRAEPFAEEVAAGFDVPLHLAREMASRVDEPMKDAVLRLYRSALTMGAEWEPELSAVSAPCVVFWGARDPACQIEFGRRLGDSLHSSEVVEMDCNHWPVLQRPAEVAEILEKHWSAHADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCK1</accession>
    <name>Q9FCK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5187</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629335.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973789.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5187"/>
    <dbReference type="GeneID" id="1100628"/>
    <dbReference type="KEGG" id="sco:SCO5187"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5271"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_11_1_11"/>
    <dbReference type="InParanoid" id="Q9FCK1"/>
    <dbReference type="OMA" id="EGIAYTE"/>
    <dbReference type="PhylomeDB" id="Q9FCK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="80" mass="8691" checksum="747191006921C28C" modified="2001-03-01" version="1">MSGTVTMYSTTWCGYCRRLKSQMDREGIAYTEVNIEQDPESAAFVEKANGGNQTVPTVLFPDGSTLTNPSLAQVKQKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3N3</accession>
    <name>Q9K3N3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1027</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625322.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977802.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1027"/>
    <dbReference type="GeneID" id="1096450"/>
    <dbReference type="KEGG" id="sco:SCO1027"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1022"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132575_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K3N3"/>
    <dbReference type="OMA" id="EVYAYRV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB96012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="157" mass="17386" checksum="2B3EC9B83CF7BE7F" modified="2000-10-01" version="1">MARRLRPVGLDFVETAPVRLVFAREVAAAPDAVFRALAEDVPGWTAWFSAVTFARPIGEGAGREIRLRGGARFVETVLAAERSDVYAYRIDVTNVPGARAMLEEWRLTPAGTGTRVRWTFAADGTAPFRFVLDRARPGLGRAFRSAVTSLDRRLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3W3</accession>
    <name>Q9K3W3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO4381</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="535"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="614" mass="65184" checksum="1BB4E78F69533D33" modified="2000-10-01" version="1"> </sequence>
</entry>
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    <accession>Q9K3W8</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="16869" checksum="49F688F348CCEAFD" modified="2000-10-01" version="1">MTTTTPTTPTAPTTDAATTDAATADAPPADARALGLAHYAARGVLEQILARHGVTFQQQVVLRAAATAQTPPTRDGLVAEVRGALKADPAGIRTVVDGLLDKGLLVADGAHLPATDAGRELLAAVGAAVAPVGARIWGGIPAEDLAAAGRVLALVTERADAEFAVLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Y3</accession>
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="206" mass="21522" checksum="3EDE88506CABA5D9" modified="2000-10-01" version="1">MPVSRRTSHQEPALANSVFDPCPTASRTASFLLPAVPAAVREGRRRVRTTLLGWGLGLDEDSSWSLTVVCGELLVRAVRRAAGGPAGRLAVGVDVEGDQVIVDVLELLDGAPPSARVRAEPPGPHGEDGWALALVGAHCTAHGTEHTPAGPRCWAVVTLPAGAFPGRPSDVERLGSTRWVVEPAGAALARAGTRVLRMGQENVPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K416</accession>
    <name>Q9K416_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flavin-dependent reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1083</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625377.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977747.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1083"/>
    <dbReference type="GeneID" id="1096506"/>
    <dbReference type="KEGG" id="sco:SCO1083"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1080"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K416"/>
    <dbReference type="OMA" id="GADWTIM"/>
    <dbReference type="PhylomeDB" id="Q9K416"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="17525" checksum="1E8DE56DAB188642" modified="2000-10-01" version="1">MTVTPDLAAPRPATDDLLRSVFRRHAAGVAVITARGPGGPAGFTATSLTSVSARPPLLSFGIGAGSSSWPAVSEAEHVGVHVLGEHQEELAATFARSGADRFAAPTVWREGPEGVPVLEGVLAWLVCRVVGRVPAGDHRIVLAEVLLGDPAGAGEPLLYHQGRYRGLRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4E3</accession>
    <name>PRMC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="1">RF MTase</shortName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmC</name>
        <name type="ordered locus">SCO5361</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629500.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973636.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4E3"/>
    <dbReference type="SMR" id="Q9K4E3"/>
    <dbReference type="STRING" id="100226.SCO5361"/>
    <dbReference type="GeneID" id="1100801"/>
    <dbReference type="KEGG" id="sco:SCO5361"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5441"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_4_0_11"/>
    <dbReference type="InParanoid" id="Q9K4E3"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="PhylomeDB" id="Q9K4E3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000414545" description="Release factor glutamine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="281" mass="31073" checksum="588A4217630BED5B" modified="2000-10-01" version="1">MNLLLAEVAQATQRLADAGVPSPRTDAEELAAYLHGVKRGELHTVPDADFDARYWEVVARREAREPLQHITGRAYFRYLELQVGPGVFVPRPETESVVGWAIDAVRAMDVVEPCIVDLCTGSGAIALALAQEVPRSRVHAVELSEDALKWTRRNMEGSRVDLRQGDALTAFPDLDGQVDLVVSNPPYIPLTEWEYVAPEARDHDPELALFSGEDGLDLIRGLERTAHRLLRPGGVVVVEHADTQGGQVPWIFTEERGWADAADHPDLNNRPRFATARKALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4L8</accession>
    <name>Q9K4L8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971845.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7296"/>
    <dbReference type="GeneID" id="1102734"/>
    <dbReference type="KEGG" id="sco:SCO7296"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7398"/>
    <dbReference type="eggNOG" id="COG5207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166099_0_0_11"/>
    <dbReference type="OMA" id="QCGHIGC"/>
    <dbReference type="PhylomeDB" id="Q9K4L8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="12459" checksum="30E54B431CB8722A" modified="2000-10-01" version="1">MTSDTGIDPTVPPSGTGCVECDAADGWWFHLRRCASCGHVGCCDSSPGQHATGHYRSTGHPVVQSFEPGEEWYWDYATSEVRESGPELAPPGSHPADQPSPGPAGRVPADWASTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYB3</accession>
    <name>Q9KYB3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6920</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630987.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031302.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6920"/>
    <dbReference type="GeneID" id="1102358"/>
    <dbReference type="KEGG" id="sco:SCO6920"/>
    <dbReference type="eggNOG" id="ENOG5031TDK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173386_0_0_11"/>
    <dbReference type="OMA" id="TGQWLVQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="12088" checksum="3A6B78C693CC6782" modified="2000-10-01" version="1">MRLNSAKPQLKARTRKGGPVPRRATAPVRRYAVTPHPPRSSQPTTADADAWADVLVRRQLLHAVVLTPTGQWLVQDRPNGPVRVLASPADVLALAATIQQRTRSTRSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYC5</accession>
    <name>Q9KYC5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6905</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630974.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6905"/>
    <dbReference type="GeneID" id="1102344"/>
    <dbReference type="KEGG" id="sco:SCO6905"/>
    <dbReference type="eggNOG" id="ENOG5032JKW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167630_0_0_11"/>
    <dbReference type="OMA" id="DRWIAEE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046200">
        <property type="entry name" value="DUF6233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19746">
        <property type="entry name" value="DUF6233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="125" mass="14761" checksum="4F2CEF7D32093584" modified="2000-10-01" version="1">MFENRPSTIERVSDTPSRLELLQFTRRVVEQQARASLRQLDRWIADEERRETERRQAEERRPPPPEWLIERGLDRSSLLAVHTGDCWDPGKRQMPTTREQARDAIRQQVPACSKCRPDTRLGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYM9</accession>
    <name>Q9KYM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7356</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631409.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971787.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7356"/>
    <dbReference type="GeneID" id="1102794"/>
    <dbReference type="KEGG" id="sco:SCO7356"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7459"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KYM9"/>
    <dbReference type="OMA" id="PGRHHGY"/>
    <dbReference type="PhylomeDB" id="Q9KYM9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB92199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="276" mass="30632" checksum="98DE093C031C9751" modified="2000-10-01" version="1">MISIPAYTLNDGTSLPALGLGTWPMKDEEAERAVRAALETGYRLIDTATNYRNETGVGRGVASAGLPREEIVVTTKLPGRHHGYEETLASFEESRARLGLEYVDLYLIHWPLPRVDKYVDSWKAMVKLREDGLVRSVGVSNFTAEHIERLERETGVLPSVNQIELHPLLPQDELRAYHERKGIRTESWSPLGRGSDLLDDPAVAAVAAAHGVTPAQAVLRWHTQLGAVPIPKSADPARQRANLDVFGFELDAEQLRAVADRVHRRIGGDPEVHEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYV1</accession>
    <name>Q9KYV1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3194</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627408.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028820.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3194"/>
    <dbReference type="DNASU" id="1098628"/>
    <dbReference type="GeneID" id="1098628"/>
    <dbReference type="KEGG" id="sco:SCO3194"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3254"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GO" id="GO:0018104">
        <property type="term" value="P:peptidoglycan-protein cross-linking"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TAT"/>
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        <location>
            <begin position="1"/>
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            <begin position="247"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB90978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="42076" checksum="E9CED17F8706C881" modified="2000-10-01" version="1">MTTPDIAKRRVLGACAALVVGALTLTACGGSASADDKQDGKGGAGSADTSVAKLVISAKDGSTGASINSTGVKVSDGKLTDVKMTVAESGAAVPGAVSGDGGSWKPKGQLERGTKYRITARAKDADGRTAAADSVFTTVSSDNSFVGTYTPDGGSTVGVGMPVSFTFDKAITDRKSVQSHISVTSSSGQEVVGHWFGGQRLDFRPEEYWKAGSKVTMKIDLDGVEGANGLYGVQKKTVSFTVGRAQVSTVDANTQTMTVVRDGKTLKSVPISAGSAANPTYNGQMVISEKSEQTRMNGSTVGFGGEYDIPDVPHAMRLSQSGTFIHGNYWYNRGNPPFGAQGTSHGCVGLADAQGAQGDTPGKWFYDNSLVGDVVVVKNSPDDTVAPDNGLNGWNMPWSEWTAQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZI4</accession>
    <name>Q9KZI4_STRCO</name>
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        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1161</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB88945.1"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO1161"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1159"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061170_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZI4"/>
    <dbReference type="OMA" id="VMGVAVC"/>
    <dbReference type="PhylomeDB" id="Q9KZI4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="MHYT_dom"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MHYT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="23"/>
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        <location>
            <begin position="24"/>
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        </location>
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            <begin position="33"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="25093" checksum="A5DA0DE24E8965B1" modified="2000-10-01" version="1">MLSYAMACTGSALGLRCTVRALAATGRTRRNWLLTAASAIGTGIWTMHFVAMLGFRVSGTDIRYDVPLTLVSLLVAVLVVCAGVFAVGHGRNRAPALLLGGLTTGIGVASMHYLGMAAMRLHGEVNYDPVRVGLSVLIAVAAATAALWAALNTRSPLAVAAASLIMGAAVSSMHYTGMFAVSVRVTPSGEALPGATAMQFIFPLAVGLGSYLFLTSAFVALSPPAREREASASDRQQPAGSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0I1</accession>
    <name>Q9L0I1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4776</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029855.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4776"/>
    <dbReference type="GeneID" id="1100217"/>
    <dbReference type="KEGG" id="sco:SCO4776"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4849"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006299_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0I1"/>
    <dbReference type="OMA" id="GPVHENW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="979" mass="100714" checksum="9A549F8C14149793" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0N4</accession>
    <name>Q9L0N4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4257</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628431.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029535.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4257"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1099697"/>
    <dbReference type="KEGG" id="sco:SCO4257"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4324"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045395_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0N4"/>
    <dbReference type="OMA" id="ANCHEEG"/>
    <dbReference type="PhylomeDB" id="Q9L0N4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="324"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB77351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="480" mass="51919" checksum="3C9AC8004862A582" modified="2000-10-01" version="1">MSLWTSLEPASATVDPGSSTRVRLRVRNTGDVVDEYRFEPVGDVAPWTTVEPQTLRLYPGTTGTVELTFAPPRTSDAVAGPNPYAVRILPTEHPDAVTVPEGNLTITAFTEVRAELVPPTVKGRFRGRPRLAVDNLGNTKVTASIAGSDHGDHLSYEVRPGNVQIEPGRAAFVETTLKPKRIIWFGAKEERPYTLAVRRSGVDPTEIEGTYVQRGFLPRWLATFFGIFLALAIAFVMIWIAYKPQVRTSATEQTEQAGVALAPSPSATPETLPSSAESAPEAEPEQPASEKPENDGAGDGGGGDGGDKGGGGESKKPAKPDVVPAMNVMLRNATTHMCADIPGRDKGKINGIVQQANCHEEGDNEFWNLEVKYENGGPNGAKLFQIRNVTDQLCMDLGEYGARPEGTGVAEFHCNGTKADNQLWWIDKQASGDYWIRNFASAHKCLNVKGQNGGTETPLNIATCTNTDDQEWEIIHPSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0S4</accession>
    <name>Q9L0S4_STRCO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">SCO4520</name>
    </gene>
    <organism evidence="2">
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974422.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4520"/>
    <dbReference type="GeneID" id="1099960"/>
    <dbReference type="KEGG" id="sco:SCO4520"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4592"/>
    <dbReference type="eggNOG" id="ENOG5031UYS">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_172312_1_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="101" mass="11348" checksum="0678B3C0FCAEFF12" modified="2000-10-01" version="1">MSFLKFFSDDVKEMAKALENSGGRMKEASQEMKRADSSQVGHSELQSACDDFADSWDYGFGQLSKLTKGVSKFADKASEEFLKMDQTLYDELKKSATKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0T5</accession>
    <name>Q9L0T5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628673.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4509"/>
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    <dbReference type="KEGG" id="sco:SCO4509"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4583"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="14040" checksum="B8786CF20661FCEF" modified="2000-10-01" version="1">MRRFDPHTRSHGGWPCGVVRGSGFMPKDLDITYQDMRDAAKHVVKEKEKLQEKLDGLRKYIANLVESGYVTKSSSKAFDDNFDEFTRGAKDTLDGLDGMGDYLTMAADKFEQIDDELAKQARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0X1</accession>
    <name>Q9L0X1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">SCO3733</name>
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    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627924.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975207.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3733"/>
    <dbReference type="GeneID" id="1099169"/>
    <dbReference type="KEGG" id="sco:SCO3733"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3794"/>
    <dbReference type="eggNOG" id="ENOG5034769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2275908_0_0_11"/>
    <dbReference type="OMA" id="IGRRRYP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="109" mass="11452" checksum="0599E45DA39C7A75" modified="2000-10-01" version="1">MRCVIARYPFDLTKSGVLDSMKGVTPEPVTGESVTIGRRRYPVKQVGEVVTRQDRRDFSGGEVTRAMARLGFTCHPAPGAEPASPAPAATPVEAASALLGGTVGTPQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1D3</accession>
    <name>Q9L1D3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625827.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027843.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1549"/>
    <dbReference type="GeneID" id="1096980"/>
    <dbReference type="KEGG" id="sco:SCO1549"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1560"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055446_0_0_11"/>
    <dbReference type="OMA" id="DACARMA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="64"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="312" mass="32324" checksum="A9E75F8C1DCE1C9F" modified="2000-10-01" version="1">MTTDAPALLPALQARVRETAHARTPAGCPCGAATLADRPDATVVRHAGTVAKAHAADADPAELSLRVTAAARLPGVLLPPLAPAPVDLHGRLVTYWPYGTPVDPEDPDAAPWEAAATLLARLHRTPVPAALPPMRGPAKAARAAARLSDTARDHPATAPVLAAWAALPAWARGEAAMPGPAALCHGDLHLGQLIRHPAPDGPWLLIDVDDLGTGVPAWDLARPAAWYACGLLPPEEWHRFLTAYRAAGGPAVPAEGDPWPALDVPARALTAQTAARAVAKAVLAGRALDEVERSLVDACARMASVRPADPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1M3</accession>
    <name>Q9L1M3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6892</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630962.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031277.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6892"/>
    <dbReference type="GeneID" id="1102331"/>
    <dbReference type="KEGG" id="sco:SCO6892"/>
    <dbReference type="eggNOG" id="ENOG5031HUW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651126_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="16933" checksum="CEBEE8153F2EC44C" modified="2000-10-01" version="1">MSRHKATTLDGDLQQVFGNPVAELYEAAAGRDASPALARALELRSFLALTEEQVALVRDRVHADMDPDRDMDELSADTLRFDAPVAGSSTGGPRRLPRSPRRAAAHHAPACKANPARSRGTAQGHRHPASVCRPGTSACRGGPGPPTVKALDCPTSRLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1T5</accession>
    <name>Q9L1T5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627184.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028684.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2960"/>
    <dbReference type="GeneID" id="1098393"/>
    <dbReference type="KEGG" id="sco:SCO2960"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3018"/>
    <dbReference type="eggNOG" id="ENOG503430D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067818_0_0_11"/>
    <dbReference type="OMA" id="QYPNAGD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB72206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="33929" checksum="1A8C6B346FFF9D72" modified="2000-10-01" version="1">MSKRQTRKMLELMASGEPVQLTSRMSSVKKLAKLAFVAQQFGYEYADVRQSGGNNAALTMLLVPDPSPQARTRAAQNWAQYPNAGDGVSLPPLVPDAFELLKARINFDLTGKNAQKNMGYGALGGTVACVVIAFREGGSSDDFLISGIIWLVLMAALGIGFLVTRKRNAKFAARLQAAGFVPMADETGRVRYLPPGGQLPGHGNPFGAVPGGYGQPAPGQYAAQPPQQQPYGGPQQAQQPYAPQPVPQAQPYAAPQAQQPYAPPQTQQPYPPQQPPQPYAQPQQQPYAPPQPQQPYPAQGHPQQNPHWQPRPPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1X8</accession>
    <name>Q9L1X8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ROK-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2657</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626893.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2657"/>
    <dbReference type="GeneID" id="1098091"/>
    <dbReference type="KEGG" id="sco:SCO2657"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2704"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="InParanoid" id="Q9L1X8"/>
    <dbReference type="OMA" id="DFVLLWN"/>
    <dbReference type="PhylomeDB" id="Q9L1X8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="409" mass="42389" checksum="0503E2DC6E403AB5" modified="2000-10-01" version="1">MWTRMAGTAGTPGTPRVLRAMNDRAALDLLLEHGPLSRTRIGKLTGLSKPTASQLLARLEAAGLVLAGGTTEGRPGPGAQLYEVNPAAAYAAGIDVTPDRVLAAVADVTGRTVGRYELPTPGRRAATPVVQQVTDALDGAVKAAGLARDDVHRLVIGTPGAFDPGTGRLRYASHLPGWHSPALLEELAAALPMPVEYENDVNLAAVAEQRLGAARGHEDFVLLWNQEGLGAALVLGGRLHRGWTGGAGEVGFLPVPGAPLVRKVSRTGSGGFQELAGSQALAGLARELGVTDVPSGPYPEVAATLVARAARADAADGPHRRLLQTYATRLATGLASLVSVLDPELVVLSGTSLTAGGEALRDLVRDELEELAASRPRLAVGDVTEHPVLRGALESALATTRDEVFDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L235</accession>
    <name>Q9L235_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630869.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6797"/>
    <dbReference type="GeneID" id="1102236"/>
    <dbReference type="KEGG" id="sco:SCO6797"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6907"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L235"/>
    <dbReference type="OMA" id="FMWDELC"/>
    <dbReference type="PhylomeDB" id="Q9L235"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB71244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="19923" checksum="56694A3FDEE26A9E" modified="2000-10-01" version="1">MAGGFGVGKTTFVGAVSEIAPLSTEELLTTVSAATDNLDGIENKLETTVAMDFGRLTLDPEHVLYLFGTPGQERFWFMWDELCEGALGAVIIADTRRLEESFAAVDFFEERGLGFVVAINEFDGSYRYDPEEVRAAMDLHPEIPIVRCDARISSSGVQTLLTLVRHLIAHTPAPTSGSGAGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2F7</accession>
    <name>Q9L2F7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2526</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB69747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626766.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028406.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2526"/>
    <dbReference type="GeneID" id="1097960"/>
    <dbReference type="KEGG" id="sco:SCO2526"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2571"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_11"/>
    <dbReference type="InParanoid" id="Q9L2F7"/>
    <dbReference type="OMA" id="YFGPGED"/>
    <dbReference type="PhylomeDB" id="Q9L2F7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="21056" checksum="1E3A1CFC5AD36B1E" modified="2000-10-01" version="1">MTAEPLERSLDHDPLTRPGLPPDDLPLDLRTARGSDLPELRRLDEEVFQDFAYPGFLLRQLFDMYEEHFLVLDDGTGRLRGYVLAATRTLGRDSWILGLCVTPDRRRHGLGRELMREVLSRLRRDGIQVVRLTVEPANLAAIFLYRSLGFRPEEPDGGLRPDYFGPGVHRQIMRLDLAPDRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD02</accession>
    <name>Q9RD02_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2263 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0909</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625208.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027437.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RD02"/>
    <dbReference type="STRING" id="100226.SCO0909"/>
    <dbReference type="GeneID" id="1096332"/>
    <dbReference type="KEGG" id="sco:SCO0909"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.903"/>
    <dbReference type="eggNOG" id="COG4295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024412_4_1_11"/>
    <dbReference type="InParanoid" id="Q9RD02"/>
    <dbReference type="OMA" id="AHRDPFY"/>
    <dbReference type="PhylomeDB" id="Q9RD02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="DUF2263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02452">
        <property type="entry name" value="TIGR02452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2263" evidence="2">
        <location>
            <begin position="59"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="34767" checksum="E04BFA9F4E40ACD8" modified="2000-05-01" version="1">MIRPFPRVFHVVRRSGNSVAPHPQHHPGFPHEHDGGDRAARGHGVHGGGAVSARLRGIAQQTEQIVAAGSYRTSDGREVPLAAAVGAARDGTRMYGPGPVEVTVPAGARTAFEVTGESSLEAARRLGGDVAVLNFASARNPGGGYLNGAQAQEEALCRASALYTCLLRAREFYDHHRAHRDPFYTDRVVHSPGVPVFRDDRGRLLDEPFTAGFLTSAAPNAGVVLRTAPERAAGLPAALTGRAERVLETAAAHGYRRLVLGAWGCGVFRNDPAQVAGAFRTLLGPGGRFAGAFERVAFGILDRTPGATVRAAFERAFPEGAVRPGQVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDB1</accession>
    <name>Q9RDB1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2840</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627069.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028612.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2840"/>
    <dbReference type="GeneID" id="1098274"/>
    <dbReference type="KEGG" id="sco:SCO2840"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2899"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9RDB1"/>
    <dbReference type="OMA" id="LMVATDH"/>
    <dbReference type="PhylomeDB" id="Q9RDB1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="32315" checksum="CFCFDE3B926B23BB" modified="2000-05-01" version="1">MVELRDIEIFLTLAEELHFGRTADRLHVSPARISQSIAKQERRIGAPLFARSSRKVELTAIGAQLRRDLGAGYQRILDGTRAATAAARGSTGTLTLGLHGSQAHDHAHLLDLFRGRHPEVALRIQEVIFTDPFGPLRNGSVDVATAWLPVREPDLTVGPVVVTEPLLLMVATDHPLTRRDAVSMEDLADWPLPHSATPIPEYWQQTLVPTHTPGGRPTRRGPKVASFQELAAVVAAGGAISLVHGDAARYYQWRGLRYLRPYDAPTASWALIWPTAGETALVRALATAARDTGPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDE6</accession>
    <name>Q9RDE6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626783.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028420.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2545"/>
    <dbReference type="GeneID" id="1097979"/>
    <dbReference type="KEGG" id="sco:SCO2545"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2590"/>
    <dbReference type="eggNOG" id="ENOG502ZBI5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672522_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDE6"/>
    <dbReference type="OMA" id="QNALWGV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="449" mass="43647" checksum="F9AA46EB0C44F8BD" modified="2000-05-01" version="1">MFAPRTTPWPLVALFTAGYLPPYLLPTTVGRLDTSLPLSTTQAGAVGSALLLSSATAGFLLASRVQRFGARTPARLGLVLAVLGYGAAALTTAVPAVVLGAVVGGFGSGTAMTVAATRIAAEKDPHRASTAGLLSVSALAGAVYLTVPHLGRAHGLPLAAIALTALAVWPLTGRLPGPAAASPAAPGADATAPLPHRRSGLVLAVTVLCWSLAQNSLWGVSGRIGLTQAGLGDATLGVVFAVALGAGLVGVLVAGALGPRLGRAMPVGAGTVLIAGCIAVSASATTPTAFATGEIAWNTVYPVVLSYLIGLAASLDARGRWAVLVGSASSLGTAAGPLAGSVLSAQAGYAGMGLVLAAGLLLVAAPMTAVALHTSGRPLLPGAIRRRGGTPAALVAAATGTPSGAVPEIGAVEQPVVEIDVEVPAVAVQGAYDTAGPRQAAAAPGSGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDK8</accession>
    <name>Q9RDK8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2578</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626816.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976225.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2578"/>
    <dbReference type="GeneID" id="1098012"/>
    <dbReference type="KEGG" id="sco:SCO2578"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2623"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450485_0_0_11"/>
    <dbReference type="OMA" id="WRLDTPY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="310"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="501"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB66256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="592" mass="62288" checksum="347FB8393300E1A8" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS7</accession>
    <name>Q9RDS7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2240</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028218.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2240"/>
    <dbReference type="GeneID" id="1097673"/>
    <dbReference type="KEGG" id="sco:SCO2240"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2278"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069355_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RDS7"/>
    <dbReference type="OMA" id="CNGDVYT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24083" checksum="84E2852DF7F4B03A" modified="2000-05-01" version="1">MGSAKKSSNTARQARIAEMRRAEEARNRRNRILTITLSTVVVAGLVVGGVFLVRSQTDDSSGDTASDGKTSGKFETGADGVRTWKGDLGRNHVTKKVTYPVEPPVGGDHNQVWMNCNGDVYTKPLNNENAVHSLEHGAVWVTYTDKAPEADVEKLAAKVKKTPYSLMSPDDKQKDPIVLSAWGHQRTVTGADDPNVDKFFEKFVQGQQTPEPGAACTNGLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJH5</accession>
    <name>Q9RJH5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0565</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB57417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978297.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0565"/>
    <dbReference type="GeneID" id="1095988"/>
    <dbReference type="KEGG" id="sco:SCO0565"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.546"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RJH5"/>
    <dbReference type="OMA" id="LRALMCY"/>
    <dbReference type="PhylomeDB" id="Q9RJH5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB57417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="352" mass="38401" checksum="B33FE0A0B336AA07" modified="2000-05-01" version="1">MSDRWDQTGLKTRVDGVLRSFLDEEAAHLAAVDAALAPVADQLRKAAGHGKRLRAAFCYWGWRAAGQPESDALVRAAASMELVHAAAVVHDDLIDDSRLRHGLPTAHVALEAVLARDGRPDARTAARSLAMLVGDQLMVLAGLLFTTSGLPAAYLARARDLWAVLARELVAGECLEILHTGGPPDTGTSLKVVRYKTAKYTVEHPLLIGGLLAGAAPALRDTYRAYALPLGEAFQLRDDLLGLFGDPERTGKASLDDLRAHRPTALLAETWKAADASQRQWLRRLLGRDDLDATHLHDVRRLMRELNAPQRVEQMIADRVERATRALDGAGTPPHARRALRELAQQATDRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJJ0</accession>
    <name>Q9RJJ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0398</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624720.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027083.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0398"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="1095821"/>
    <dbReference type="GeneID" id="1095821"/>
    <dbReference type="KEGG" id="sco:SCO0398"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.374"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_16_0_11"/>
    <dbReference type="InParanoid" id="Q9RJJ0"/>
    <dbReference type="OMA" id="HHADRTF"/>
    <dbReference type="PhylomeDB" id="Q9RJJ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB58339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="35515" checksum="2487AC0E76129E31" modified="2000-05-01" version="1">MTPHPRLSIGLPVYNGEEYLAESLDALLGQTYENFELVISDNASTDGTRDICRRYAAQDSRIRYIRLPRNIGAAPNHNYVFTECRGELFKWASHDDLYARDLLRSCVAALDERPEVVLAHAGQAVIDGDGKVKVPYEYGLATDSPRAPERFRSLLFEPGGDDFYGVMRSAMLRRVKPHDSYHHADRTFVAEITLHGPFHQVPELLYFRRDHPTRAERANPSKRSRCVNLDPRRAGPLHPTPRLLAEYVWGFASAIGRAPLSSADRRACHRHLAAWLTSRVRPGVGERVEDRAPVDPDRLTVSVDDLVAGREGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJJ4</accession>
    <name>Q9RJJ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0394</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978471.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0394"/>
    <dbReference type="GeneID" id="1095817"/>
    <dbReference type="KEGG" id="sco:SCO0394"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.370"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RJJ4"/>
    <dbReference type="OMA" id="IRGIECH"/>
    <dbReference type="PhylomeDB" id="Q9RJJ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23775" checksum="306945E60E80BEAA" modified="2000-05-01" version="1">MIRLGAGSPERIVAVGAHCDDIAIGAGGTLLTVCLARPGVRVDALVLSGGGGEREREERAALAAFCPGADLRLTVLKLPDGRMPAHWEEAKAAVEELRERTEPELVLSPRTDDAHQDHRGLAKLMTTAFRDHLVLRYEIVKWDGDLGRPTAYQPLSEDVAEEKVRLLQEHYPSQRHRPWYDREAFLGLARIRGIECHARYAEAFDVAKLTLNLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK05</accession>
    <name>Q9RK05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0501</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36419">
        <property type="entry name" value="T36419"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027164.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0501"/>
    <dbReference type="ESTHER" id="strco-SCF34.20C">
        <property type="family name" value="Lactobacillus_peptidase"/>
    </dbReference>
    <dbReference type="GeneID" id="1095924"/>
    <dbReference type="KEGG" id="sco:SCO0501"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.481"/>
    <dbReference type="eggNOG" id="COG2936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484774_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RK05"/>
    <dbReference type="OMA" id="STGCLDW"/>
    <dbReference type="PhylomeDB" id="Q9RK05"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="388"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="650" mass="69945" checksum="5D987D1173B5CF29" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK27</accession>
    <name>Q9RK27_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase, iron-sulphur binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0689</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB60470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624997.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027297.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0689"/>
    <dbReference type="GeneID" id="1096112"/>
    <dbReference type="KEGG" id="sco:SCO0689"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.675"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_1_2_11"/>
    <dbReference type="InParanoid" id="Q9RK27"/>
    <dbReference type="OMA" id="GHPSHVT"/>
    <dbReference type="PhylomeDB" id="Q9RK27"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB60470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="22502" checksum="85C3FFAB87DC9730" modified="2000-05-01" version="1">MSSGGRWIRGRHRSTGPSRKVTDAMDSQHDSAPASRPPESSRSQTTLRVNGKPHTLTVDHRRVLLDLLREDLELAGAKKGCDHGQCGACTVLVDGRRVNSCLLFAVALDGCEITTVEGLAGDGEELHPLQRAFLDRDAFQCGYCTPGQICSAVGALAEAAAGHPSHVTDPAVPSGEPVALDREEIRERLSGNLCRCGAYPRIADAVEDVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK59</accession>
    <name>Q9RK59_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO0551</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB59608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624865.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027197.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0551"/>
    <dbReference type="GeneID" id="1095974"/>
    <dbReference type="KEGG" id="sco:SCO0551"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.532"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_33_11"/>
    <dbReference type="InParanoid" id="Q9RK59"/>
    <dbReference type="OMA" id="IGNVFRH"/>
    <dbReference type="PhylomeDB" id="Q9RK59"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176924" description="Histidine kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="167"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="227"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB59608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="442" mass="46119" checksum="EB168E0A539D2C13" modified="2000-05-01" version="1">MRRALAGIALAVTSMVALSFLVPLALLVREQARDRVTTAAEQRAAALSPVLALTTRRADVQQAVAELGSADQLVVRLPDGGFVGTPHAPEEALDRAVRGRETLAVDTADGWAYLQPVVLRGDRVAVVEAYVPAADLTRGVTASWGVMALLAVGLVGGSVLVADRLGARVVRSSRGLKRASLALGSGDLGVRVEPDGPPELQEAGAAFNTMADRVVDLLAVERELVADLSHRLRTPLTALYLEADRMGATPSALRVTEAAGQLERELDSIIAAARTPLAAAQLAGTGAGTAKPCDVAEVVAMRLDFWSVLAAQQDRPFERSLTPRPAPVAFPEDDLAAVVDALIGNVFRHTPQGTRFVVRVERRDRHVRLTVDDAGPGVADPEAALTRGVSVGGSTGLGLDIVARAARTADGELTITRAPLGGARVTVSFALADARAAGDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK70</accession>
    <name>Q9RK70_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable sugar transport membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0540</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624854.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027191.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0540"/>
    <dbReference type="GeneID" id="1095963"/>
    <dbReference type="KEGG" id="sco:SCO0540"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.520"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RK70"/>
    <dbReference type="OMA" id="NAMFPRW"/>
    <dbReference type="PhylomeDB" id="Q9RK70"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="95"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB59597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="32702" checksum="041D5FFC8FCD454E" modified="2000-05-01" version="1">MTATSARPDTAVGAHHLAKAPAAGERRRPRLPFSPWHLLLAPLALVFAVPLVWLVLSSVMSNAEINRFPPALWPSGIDLGGYRYVLGNAMFPRWFVNSLIVSAVTVAANLVFGSLAGYAFARMRFAGSRVLMGLMLATMAVPFQLTMIPTFLVMKKLGLIDTLGALIVPSLVTPFAVFLLRQFFLSLPRELEEAAWIDGCSRLRVLWRIVLPLSRPALATVAVLTFLTTWNDLTWPLIAINHDTQYTLQLGLTTFQGQHHTQWAAVMAGNVITVLPVLLAFLGAQKTFIQSITSSGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKM7</accession>
    <name>Q9RKM7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4100</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628280.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029432.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4100"/>
    <dbReference type="GeneID" id="1099537"/>
    <dbReference type="KEGG" id="sco:SCO4100"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4159"/>
    <dbReference type="eggNOG" id="ENOG5031RRG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969306_0_0_11"/>
    <dbReference type="OMA" id="YAVACTN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="14107" checksum="41DE4B832EADAA62" modified="2000-05-01" version="1">MSTTPPGDSLVDLRPRRVTPRRLGAAAVVYGVFVAGWYLGQPVTPECHVDRAALDRAAERYRPEPSPTPTYSPIPSPSPSAYPGRSSLADAHTAQGPMVMSLTYTSYAVACTNDMGERPRLRAWFDGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKY1</accession>
    <name>Q9RKY1_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1422</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625704.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977403.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1422"/>
    <dbReference type="GeneID" id="1096848"/>
    <dbReference type="KEGG" id="sco:SCO1422"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1432"/>
    <dbReference type="eggNOG" id="COG3030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085083_2_0_11"/>
    <dbReference type="OMA" id="FQQVRIH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="194" mass="20882" checksum="C8F0B77F12368B3A" modified="2000-05-01" version="1">MTTGAQTPRSPARPPRSRLRTFLPLGAAAWLVLEIWLLTVIAGATSGFMVFLLLVAGVVLGSMVIKAAGRRAFRNLTETLNQQQSAMRTGVPPEARPNSEGNGLMMLGGLLLILPGPISDVLGLLMLLPPVQKGVSRYAQRTVERKLRDAGPGTLGDAFRQARMQHPDGKVVQGEVIRDDPDDAPQDPRPPLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKZ0</accession>
    <name>Q9RKZ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1432</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625714.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027785.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1432"/>
    <dbReference type="GeneID" id="1096858"/>
    <dbReference type="KEGG" id="sco:SCO1432"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1442"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054370_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKZ0"/>
    <dbReference type="OMA" id="DNGGEAW"/>
    <dbReference type="PhylomeDB" id="Q9RKZ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02549">
        <property type="entry name" value="Peptidase_C39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039563">
        <property type="entry name" value="Peptidase_C39_single_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331874" evidence="2">
        <location>
            <begin position="50"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="3">
        <location>
            <begin position="266"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="51802" checksum="74D62282D2BB01AD" modified="2000-05-01" version="1">MQRRTRPTRTPGGLPLMSRVEQPSRRALLAAAVAAAAVTGGAIPATARAASRAGVGGGAAGPGRDSARRPVDYRAWTTLGDWRRGTVRGARPVAGARPGVVIGAPAGTVDYADPHTGTTATWEYATWTSPVHRLAVPSTEVIASWNAHTPGGTWIQVELKGTYSDGTDTPWYVMGRWTAGDGEQDIRRTSVDDQGDGRSSIWTDTFSIDDASTGLRLASYRLRLTLHRRPGTRTTPTVWRLGAMGSDVPDRFTVPASTPGYAGELRVPRYSQEIHKGQYPEYDNGGEAWCSPTSSQMIIEYWGGRLTEDQLAWVDPSYADPQICHAARYTYDNQYEGCGNWPFNAAYAATFKGLQGVVTRLGSLTDLETLIAAGIPAITSQSFLEEELTGSGYGTSGHLMTVIGFTADGDVIANDPASDDNDAVRRVYRRREWENIWLRTKRYNASGKVVSGTGGVCYLYFPAHPGPRQRKALAAVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1X6</accession>
    <name>Q9S1X6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0017</name>
        <name evidence="3" type="ordered locus">SCO7830</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37080">
        <property type="entry name" value="T37080"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624378.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631858.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026780.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095451"/>
    <dbReference type="GeneID" id="1103268"/>
    <dbReference type="KEGG" id="sco:SCO0017"/>
    <dbReference type="KEGG" id="sco:SCO7830"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.16"/>
    <dbReference type="eggNOG" id="ENOG503298V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2144436_0_0_11"/>
    <dbReference type="OMA" id="SAFDHIT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046200">
        <property type="entry name" value="DUF6233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19746">
        <property type="entry name" value="DUF6233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC03648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="12152" checksum="BBBEBA265E7E5EBB" modified="2000-05-01" version="1">MRAPEHVRPVDGVDYNQVSTGPLPPAPPTPTGREGLWERRPSGWVLAKVRSGRGPARGVPHAPECAEAPEGVPLLDVRRALDVAEKPGTQLCTLCGCAQELTPLLSAFDHITDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S245</accession>
    <name>Q9S245_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC sugar transporter, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1707</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36808">
        <property type="entry name" value="T36808"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625981.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977118.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1707"/>
    <dbReference type="GeneID" id="1097138"/>
    <dbReference type="KEGG" id="sco:SCO1707"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1725"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="InParanoid" id="Q9S245"/>
    <dbReference type="OMA" id="HHGHESL"/>
    <dbReference type="PhylomeDB" id="Q9S245"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB46805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="445" mass="48829" checksum="5EBFA4F8D20F95FD" modified="2000-05-01" version="1">MTRAISLHDVSKTYARGVRVVDRLSLDIAPGEFLVLLGPSGCGKSTVLRMIAGLEEITEGELTLDGAYANDLLPAERRMAMVFQNFALYPNMTTRGNIGFPLRVEDPQTDHTPRVDATARMLGIEDLLDRLPAQLSGGERQRVAMGRAISRHPTAFLMDEPLSNLDAKLRNHLRAEITRLTRELGVTTIYVTHDQSEAMSLGDRVAVLRGGVLQQVDTPRAVYALPRNVFVAAFIGTPRINLLRGLVRAPLDGAMTISLGKQFLRLPEPLSLDHQLLRVQQGREVIVGLRSEAVRIAKPSSARPGEVLLTGLVEHVEFQGHEVLVHFNTGSQPAVVPDLEAPRPAARPVRRRRRDGTVLERLRERAGALRAGPVVVMDEPPEPGPAVAAPDGRLPGDLIVRTTPDIDLRHGMQVPLLVDLAHLFVFDQHGDRICPAPARLPDLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S248</accession>
    <name>Q9S248_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1704</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36805">
        <property type="entry name" value="T36805"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625978.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027928.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1704"/>
    <dbReference type="GeneID" id="1097135"/>
    <dbReference type="KEGG" id="sco:SCO1704"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1722"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_1_11"/>
    <dbReference type="InParanoid" id="Q9S248"/>
    <dbReference type="OMA" id="TLNMVYL"/>
    <dbReference type="PhylomeDB" id="Q9S248"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="164"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB46802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="33059" checksum="EA43D93493741515" modified="2000-05-01" version="1">MMTTARTSPPAPWHRRPDLLAAGAATVTVVLWASAFVSIRSAGEAYSPGALALGRLLSGVLTLGAIWLLRREGLPPRAAWRGIAISGLLWFGFYMVVLNWGEQQVDAGTAALVVNVGPILIALLGARLLGDALPPRLLTGMAVSFAGAVTVGLSMSGEGGSSLFGVVLCLLAAVAYAGGVVAQKPALAHASALQVTTFGCLVGAVLCLPFAGQLVHEAAGAPVSATLNMVYLGVFPTALAFTTWAYALARTTAGRMGATTYAVPALVVLMSWLALGEVPGLLTLAGGALCLAGVAVSRSRRRPAAVPDRAAPTAEPRREDAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S263</accession>
    <name>Q9S263_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1689</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36790">
        <property type="entry name" value="T36790"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625963.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027920.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1689"/>
    <dbReference type="GeneID" id="1097120"/>
    <dbReference type="KEGG" id="sco:SCO1689"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1706"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S263"/>
    <dbReference type="OMA" id="FVDYYAE"/>
    <dbReference type="PhylomeDB" id="Q9S263"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="37410" checksum="25F37593EBF05A67" modified="2000-05-01" version="1">MSPDHPPGLDLDRLRVLLDRERPGLVTGPLSGRLIEGGRSNLTYAVTDGTARWVVRRPPLGHVLATAHDMRREHRVISALHPTDVPVPRPVLLCEDEEVLGAPFYVMEFVDGTPYRTSEQLAPLGPERTRAAVLNLVDTLVGLHAVDPAEVGLADFGRPEGFLDRQLRRWAKQLDASRNRDLAGIDELHATLGRELPRSPAPTVVHGDYRLDNVLIGGEGDEIRAILDWEMSTLGDPLTDLGLLVMYSSPLGMPDSPVSTTAQAPGHPAPAELVERYAARSGRDVSTVAWYTAFAWFKLAVILEGIHYRYTLGQTVGRGFDRIGDLVPVFIEHGLTTLQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S277</accession>
    <name>Q9S277_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1812</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36776">
        <property type="entry name" value="T36776"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626081.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1812"/>
    <dbReference type="GeneID" id="1097246"/>
    <dbReference type="KEGG" id="sco:SCO1812"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1833"/>
    <dbReference type="eggNOG" id="COG2807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038046_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S277"/>
    <dbReference type="OMA" id="RDPLAWQ"/>
    <dbReference type="PhylomeDB" id="Q9S277"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004747">
        <property type="entry name" value="Cyan_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00896">
        <property type="entry name" value="CynX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB50880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="421" mass="43492" checksum="48EADE66F7D71490" modified="2000-05-01" version="1">MSEVPGEASATRAWTTWTTRLLILGIVLAAVNLRPAITSLGALLEEVRDGLGMSGSIAGLLTSVPPLCFAVFGVTAPRLARRFGPGAVVCAGMVAITAGLLIRPYAGGTGGFLAATALALMGIAVSNVLMPVIVKRYFPDRVGSMTGLYSMALAFGTSVAAAATVPLTDALGGHWQPGLAVWAVLPALAVLPWIPFVRNRKAPASTAPYAPRPEDGRSAEKRAEQPPLRITRSRTAWALAVFFGLQATAAYITMGWMAQIFRDSGVSAGTAGLLLAVIMVMGVPLAFVIPRVASRLPHQGPIVVVLGVCGLAGYAGLYFAPVGGAWAWALLLGVSNCAFPLALTMVGMRARTGAGVAQLSAFAQSTGYLISIPGPLLVGVLYQHSGGWGLPIALMSALMVPQIVVGVLAGRDRTVEDEAGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7R6</accession>
    <name>RNH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease HI</fullName>
            <shortName>RNase HI</shortName>
            <ecNumber>3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rnhA</name>
        <name type="ordered locus">SCO7284</name>
        <name type="ORF">SC5H1.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase H family.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB42933" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.1.26.4"/>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42933.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35324">
        <property type="entry name" value="T35324"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631340.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X7R6"/>
    <dbReference type="SMR" id="Q9X7R6"/>
    <dbReference type="STRING" id="100226.SCO7284"/>
    <dbReference type="GeneID" id="1102722"/>
    <dbReference type="KEGG" id="sco:SCO7284"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7386"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_1_11"/>
    <dbReference type="InParanoid" id="Q9X7R6"/>
    <dbReference type="PhylomeDB" id="Q9X7R6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090502">
        <property type="term" value="P:RNA phosphodiester bond hydrolysis, endonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195406" description="Ribonuclease HI">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="231" mass="24297" checksum="C650C6945CC1899A" modified="2000-05-30" version="2">MRERAVAACDGASKGNPGPAGWAWVVADASENPVRWEAGPLGKATNNIAELTALERLLASTDPDVPLEVRMDSQYAMKAVTTWLPGWKRNGWKTAAGKPVANRELVVRIDELLDGRSVEFRYVPAHQVDGDRLNDFADRAASQAAVVQEAAGSALGSPEPPPAPDVPAARRAPRRGSSGAARKGGGGSSARTIKAKFPGRCLCGRPYAAGEPIAKNDQGWGHPECRTVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Y9</accession>
    <name>Q9X7Y9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35512">
        <property type="entry name" value="T35512"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626386.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028154.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2130"/>
    <dbReference type="GeneID" id="1097564"/>
    <dbReference type="KEGG" id="sco:SCO2130"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2165"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034119_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7Y9"/>
    <dbReference type="OMA" id="ECVNVGH"/>
    <dbReference type="PhylomeDB" id="Q9X7Y9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB39857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="29384" checksum="837C720A496C38EF" modified="1999-11-01" version="1">MAPTPPRNTSTRVHVVSDVHGNARDLARAGDGADALICLGDLVLFLDYADHSRGIFPDLFGVANADRIVALRTARRFEEAREFGRRLWAEAGGEPRELIERAVRKQYAELFAAFPTPTYATYGNVDVPPLWPEYAGPGTTVLDGERVEIGGRVFGFVGGGLRTPMNTPYEISDEEYAAKIEAVGEVDVLCTHIPPEVPELVYDTVARRFERGSRALLDAIRRTRPRYALFGHVHQPLVRRMRVGATECVNVGHFASSGRPWALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G6</accession>
    <name>Q9X8G6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycine-rich secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3342</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36291">
        <property type="entry name" value="T36291"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627551.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028922.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3342"/>
    <dbReference type="GeneID" id="1098779"/>
    <dbReference type="KEGG" id="sco:SCO3342"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3404"/>
    <dbReference type="eggNOG" id="ENOG502ZHN7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079632_1_0_11"/>
    <dbReference type="OMA" id="AKCRTAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177020" evidence="2">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="21280" checksum="43318D34E6355171" modified="1999-11-01" version="1">MRVRKLTIAAMALAAGLSLTACQNDDDAAGQSTAPPAASTAASSDGGSGSAGSDSAESSNGTGGTGGTEGTEGSGGTGGAGEDGKAAKCSTDELEITAADATVGGDTEGTVAVDLKNGGGRDCSLAGYAGVDLKTNSGTVSAERTGDPAPRVVLKDGETVTFGITYPVNDSGGSGVRITGLVVTPPDETKSVTLDWPGGASLPVTDGSGTPVRVGPLGSAGQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8P3</accession>
    <name>Q9X8P3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3626</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36516">
        <property type="entry name" value="T36516"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627820.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029125.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3626"/>
    <dbReference type="GeneID" id="1099062"/>
    <dbReference type="KEGG" id="sco:SCO3626"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3685"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_1_11"/>
    <dbReference type="InParanoid" id="Q9X8P3"/>
    <dbReference type="OMA" id="HAWSKER"/>
    <dbReference type="PhylomeDB" id="Q9X8P3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB42013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="31591" checksum="B2F2F73062A9F4D8" modified="1999-11-01" version="1">MPARSDDMARQFELDRPRLRAVAYRILGSLGEADDALQEAWLRADRANTSEVGNPSGWLTTVVARVCLNLLRARDTRREEPLDDAARRQPAATGTAADPAEEVQLADEVGIALLIVLDTLGPAERLAFVLHDMFDVPFDDIAAMLDKTPAATRQLASRARRRVRGVPAPEADLPRRRRAVDAYLAATRGGDFDALVALLHPDVVLSADAAVVPTPEPVTVSGMEQVARGAMASMARARSAAVVLVDGMVGMAMAENGRLRVVLRFDFAADGRITGIDVIAEPARLNELDITGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8T6</accession>
    <name>Q9X8T6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3900</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36587">
        <property type="entry name" value="T36587"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628086.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975031.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3900"/>
    <dbReference type="GeneID" id="1099336"/>
    <dbReference type="KEGG" id="sco:SCO3900"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3973"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_3_0_11"/>
    <dbReference type="InParanoid" id="Q9X8T6"/>
    <dbReference type="OMA" id="APMHGYE"/>
    <dbReference type="PhylomeDB" id="Q9X8T6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="25185" checksum="856747BF4FADD5CD" modified="1999-11-01" version="1">MSRRSGILEFAVLGLLRESPMHGYELRKRLNTSLGVFRAFSYGTLYPCLKTLVANGWLIEEPGNVGEAAASLTGRRAKIVYRLTADGKEHFEQLLSQAGPDAYDDETFAARFAFFGQTSRDVRMRVLEGRRSRLEERLEKMRASLARTRERLDDYTLELQRHGMESVEREVRWLNELIESERAGRDLRGSAAEGTAQQDTTSGATGGLPRPGDDSRPDTPGDTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9T8</accession>
    <name>Q9X9T8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3930</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37183">
        <property type="entry name" value="T37183"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628115.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029317.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3930"/>
    <dbReference type="GeneID" id="1099366"/>
    <dbReference type="KEGG" id="sco:SCO3930"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440276_0_0_11"/>
    <dbReference type="OMA" id="ARAHEYL"/>
    <dbReference type="PhylomeDB" id="Q9X9T8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="46"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="188" mass="20083" checksum="F3A2AAE0E662C404" modified="1999-11-01" version="1">MDARRARAHEYLAEELDAYAHWYVAPASSSGGHFLTLTLFAECGNAARAARGQTAEFLRGAGADDVVDDARLIVSELVGNVVNHAVPEPSLSRPDGSRRIDVEFKMWPKWLFIGVADEDSTPPLLPLGDTFSPDLLGPLSEAVLPDSGRGLLIVQRLAAAVWWTPKDGGGKTVWCRLDLDGASGGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA51</accession>
    <name>Q9XA51_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3827</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36508">
        <property type="entry name" value="T36508"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628016.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029253.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3827"/>
    <dbReference type="GeneID" id="1099263"/>
    <dbReference type="KEGG" id="sco:SCO3827"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3896"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_1_2_11"/>
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    <dbReference type="OMA" id="VDHVHPT"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
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    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
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        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="9">
        <location>
            <begin position="241"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB46950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="465" mass="48289" checksum="8AA37ECDFD50E9CF" modified="1999-11-01" version="1">MTSPGTRADADAEDLDVEEALALVRETPGHGSHDNGSHGSHGRRDSHGGHGAPAPHHPADAHHQTTPWPEARATAERAARTAARAARRTPVAVPLDAALGLTLAAPLAALTDLPSFDTSAMDGWAVAGPGPWAVRDEGVLAGHAAPAPLIDGEAVRIATGARIPPDTTAVLRTEHGRSDERGRLHPTREVVHGQDIRPRGQECRSGDQLLPVGTLATPAVLGLAAAAGYDTLTAVPRPRVDVLVLGDELLTQGLPHDGLIRDALGPMLPPWLRALGAEVRTVRRIGDDAKALHRAVTTSEADLIVTTGGTAAGPVDHVHPTLRRIGAELLVDGVKARPGHPMLLARLKDDQHLVGLPGNPLAAVSGLLTLAEPLLRTLAARPAPEPYTLPLRDAVHGHPHDTRLVPVVLRGEGAVPLRYNGPAMLRGIAAADALAVVPPGGARSGQEAELLDLPWATGGIGVCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA69</accession>
    <name>Q9XA69_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36489">
        <property type="entry name" value="T36489"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627997.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029242.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3808"/>
    <dbReference type="GeneID" id="1099244"/>
    <dbReference type="KEGG" id="sco:SCO3808"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3876"/>
    <dbReference type="eggNOG" id="ENOG5032RB5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078210_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA69"/>
    <dbReference type="OMA" id="VDVRRHH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="168"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="30743" checksum="6584E85E684764A4" modified="1999-11-01" version="1">MSLHPALQPYADAWTHSIEAISELVQPLVEAEWNRRTPCPGWSVRDIVSHVLGLDSEMLGDPRPIHTLPRDLYHVTNDHQRYMEMQVDVRRHHTAPEMTSELEYMIIRRNRQLRNESRDPGTKVRGPLGTELTLEEAMRRHAFDVWAHEQDLRTALGRPGNLDSPGAHVARDVLLGELPAVVAEQADAPRSSAVVFDVHGPVEFLRTIRVDIQGRGTLESSPALGPAATLTLDWETYFRLACGRVTPEAAADRIKTEGDPDLTAAILRHFTVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAG3</accession>
    <name>Q9XAG3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5322</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35607">
        <property type="entry name" value="T35607"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030173.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5322"/>
    <dbReference type="GeneID" id="1100762"/>
    <dbReference type="KEGG" id="sco:SCO5322"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5408"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055284_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAG3"/>
    <dbReference type="OMA" id="CASGFAY"/>
    <dbReference type="PhylomeDB" id="Q9XAG3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="51"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="289" mass="29888" checksum="E54D4046F6435849" modified="1999-11-01" version="1">MVPVTGGVTDVADTALVLGGGGLTAYGWQIGVLAGLADAGVDLADADVLAGTSAGSLLALDLARGAAPAGLYKEQLDRERPMLDVDFTFGMTVRYLWAALGSRDPETVVRRLGRLALSVRDVPQSAVFAAIGAQLPVRDWPDRTVRMFAVDALTGEPTAFDADSGVDLLHAMSATCALPPLFPPISIGAGRWMDGGVRSTTNADLVDDCARVVVLAPIPKGAGASPSARTQAETLASRGARVALLTPDRAARRAFGRNALDASRIPGAAREGRRQGAAHAGRIGEIWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAH8</accession>
    <name>Q9XAH8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6686</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB46974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35546">
        <property type="entry name" value="T35546"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630760.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031104.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6686"/>
    <dbReference type="GeneID" id="1102125"/>
    <dbReference type="KEGG" id="sco:SCO6686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6791"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983037_0_0_11"/>
    <dbReference type="OMA" id="QIHRATW"/>
    <dbReference type="PhylomeDB" id="Q9XAH8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="31805" checksum="284E1544A2B5ABD8" modified="1999-11-01" version="1">MGWLAAGDTYEVALVEGRVVARSASAKSPAEGRRERTLPAEIRERPEVVELQRFAEWLDRHAAECVAQVDNWMVSSLPVPTALLAQVWPDEAWQTALRDIVVVGEGPDEVGFLRDADESQGLRVVNLDGETVRLTSRTVTMPHPVLLPDLEELRTFAAESGVVQGVEQIHRATWPAPGDSDGGDTDVVTEFAGAEYRSWFHLSARATSLGYRISGSRVVDRIRDAGRVFTASVGMSDPYTEEKAWTGGLSWSHGDGYRSLPLHEVGPVAYSEGMRMAAALHAGRTVPTDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAL5</accession>
    <name>Q9XAL5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">SCO6715</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB45589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35033">
        <property type="entry name" value="T35033"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630788.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031128.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6715"/>
    <dbReference type="GeneID" id="1102154"/>
    <dbReference type="KEGG" id="sco:SCO6715"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6822"/>
    <dbReference type="eggNOG" id="ENOG5032RUK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106245_6_1_11"/>
    <dbReference type="OMA" id="EFFFPAP"/>
    <dbReference type="PhylomeDB" id="Q9XAL5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB45589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="8989" checksum="259FE3DBD2E31340" modified="1999-11-01" version="1">MHTETTAAPDLSWQEEALCAQTGGDFFFPEPGSSVRDAKRICALCPIRSTCLEFALSNDERFGVWGGLSEKERLALRRTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAN8</accession>
    <name>Q9XAN8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6692</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35010">
        <property type="entry name" value="T35010"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630765.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031110.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6692"/>
    <dbReference type="GeneID" id="1102131"/>
    <dbReference type="KEGG" id="sco:SCO6692"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6797"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029929_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAN8"/>
    <dbReference type="OMA" id="WSAVGLN"/>
    <dbReference type="PhylomeDB" id="Q9XAN8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177049" evidence="3">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="30829" checksum="3372F5FB132062B9" modified="1999-11-01" version="1">MNAALVAVLLSLVSACAYAAAAVAQERLASRASGAGALRMLASGAWWWAVALNSSAALLHVVALKYGPLTVVQPLGALTLVAAVPLGARLAGRRVSAIEWRGTGLTLLGLGALLLTASGPAPDDVLSVPEALTVSGATAALIGVLSRPGARPGLRHATASGIASGVASALTQTVTVAVTDRSGPLLSVQVIGVAVLVAAFATGGLLLSQTAYRGGLGAPLAVVTLANPVAAAVIGLSLLGERLRGGAGGVLLALTGAALAAWGVLQLSRAAPDRPETAAPGLAGPGLAGTETEPTGPAPAGPGVVPRQPGPGHLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z532</accession>
    <name>Q9Z532_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptide transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5713</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35982">
        <property type="entry name" value="T35982"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030406.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5713"/>
    <dbReference type="GeneID" id="1101152"/>
    <dbReference type="KEGG" id="sco:SCO5713"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5803"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="Q9Z532"/>
    <dbReference type="OMA" id="DVLTMKW"/>
    <dbReference type="PhylomeDB" id="Q9Z532"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="398" mass="40525" checksum="C1ADA00A76296FAA" modified="1999-05-01" version="1">MSLLEVRDLKVTYPGGAAAVRGVDLTLAAGEKLGVAGESGCGKSTLALALLRLLPPGARVGGEILLDGEDVLTMKWGRVRAVRWAGASIVFQGAMHSLNAVHRVGDQIAEPILLHRRTTAAGARRRAGELLEQVGLPAARASAYPHELSGGQRQRVMIAMALACDPRLIVADEPTTALDVMIQAQILRLIEGLVGEQDVGLIMISHDLAVLADTCDRLAVMYAGRVVEEGPARQVYDDARHPYGRALSEAFPTIGDPASRFAPRGLPGDPPDPAAVPSGCAFHPRCPVALDLCATQDQPLRDAGARRRAACVHVGPDGTVPPDGAGATAGSGPPEGDTAPAGDGAGSPAGRGEPAGTRDTGEGAEPAGGAADGRSGGDGRGAGGVAPAEDDGVRSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z540</accession>
    <name>Q9Z540_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6132</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35915">
        <property type="entry name" value="T35915"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630238.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030674.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6132"/>
    <dbReference type="GeneID" id="1101573"/>
    <dbReference type="KEGG" id="sco:SCO6132"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6236"/>
    <dbReference type="HOGENOM" id="CLU_1408047_0_0_11"/>
    <dbReference type="OMA" id="TSETWPW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="20572" checksum="1BB1BAE9B3C99815" modified="1999-05-01" version="1">MTALDARVGLREYLGYWIGTVPVRVLGAAAVVTAWRPWATVDTAGAAVPFVCAVAFALWAAPSLDRRPSVEAVWWSYRLLRHRTTLLASGVVVIAAFREPAWWEGACVVALLVAYLVTSETWPWRWGRGSARVWGEAAAACAGAGVVAAAAAVPVSGTGSGLGRLIAAAAVAGLAVAGGAVLRARRQNDAPKSRAPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z577</accession>
    <name>Q9Z577_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5502</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35818">
        <property type="entry name" value="T35818"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030282.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5502"/>
    <dbReference type="GeneID" id="1100942"/>
    <dbReference type="KEGG" id="sco:SCO5502"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5587"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_1_3_11"/>
    <dbReference type="InParanoid" id="Q9Z577"/>
    <dbReference type="OMA" id="DTIVWHT"/>
    <dbReference type="PhylomeDB" id="Q9Z577"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177070" evidence="7">
        <location>
            <begin position="30"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="197"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="748" mass="77989" checksum="5B2A6152A5488BB1" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z581</accession>
    <name>GATC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Glutamyl-tRNA(Gln) amidotransferase subunit C</fullName>
            <shortName>Glu-ADT subunit C</shortName>
            <ecNumber>6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gatC</name>
        <name type="ordered locus">SCO5498</name>
        <name type="ORF">SC8D9.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35814">
        <property type="entry name" value="T35814"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629633.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973500.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z581"/>
    <dbReference type="SMR" id="Q9Z581"/>
    <dbReference type="STRING" id="100226.SCO5498"/>
    <dbReference type="GeneID" id="1100938"/>
    <dbReference type="KEGG" id="sco:SCO5498"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5582"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_1_0_11"/>
    <dbReference type="InParanoid" id="Q9Z581"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="PhylomeDB" id="Q9Z581"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105341" description="Glutamyl-tRNA(Gln) amidotransferase subunit C">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="98" mass="10779" checksum="1FB7FA571B118CC0" modified="1999-05-01" version="1">MPGITREEVAHLARLARLELKPEELEHFAGQLDDIIGAVARVSEVADQDVPPTSHPLPLTNVMRPDEVRPSLTPEQALSGAPAQEQQRFKVPQILGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBT6</accession>
    <name>Q9ZBT6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small hydrophobic protein (Putative membrane protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6152</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34665">
        <property type="entry name" value="T34665"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630257.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030690.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6152"/>
    <dbReference type="GeneID" id="1101593"/>
    <dbReference type="KEGG" id="sco:SCO6152"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6257"/>
    <dbReference type="eggNOG" id="COG2839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109297_3_1_11"/>
    <dbReference type="OMA" id="WAAVLWW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17007" checksum="B3786ECC0AD263F3" modified="1999-05-01" version="1">MGAWDLLLAGLVILLGLCGVLLPGVPGSWLVWAGVLWWALKDPRPLAWAVLVGSTVVLLLSRAVRWALPTRRKRRDEAMRRLTAYAGAGAVLGFVLVPVLGAVPGFMGGIYLAERLRLGRHGEAMASLRTAMRQGGADLLTELFACLLITGAWLGAVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBW9</accession>
    <name>Q9ZBW9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2012-08" db="PDB data bank">
            <title>DyP-type peroxidases from Stretptomyces and Thermobifida can modify organosolv lignin.</title>
            <authorList>
                <person name="Lukk T."/>
                <person name="Hetta A.M.A."/>
                <person name="Jones A."/>
                <person name="Solbiati J."/>
                <person name="Majumdar S."/>
                <person name="Cronan J.E."/>
                <person name="Gerlt J.A."/>
                <person name="Nair S.K."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH HEME</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36069">
        <property type="entry name" value="T36069"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628147.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029343.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDB" id="4GT2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/E/G=1-445"/>
    </dbReference>
    <dbReference type="PDBsum" id="4GT2"/>
    <dbReference type="SMR" id="Q9ZBW9"/>
    <dbReference type="STRING" id="100226.SCO3963"/>
    <dbReference type="GeneID" id="1099399"/>
    <dbReference type="KEGG" id="sco:SCO3963"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4035"/>
    <dbReference type="eggNOG" id="COG2837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039488_1_2_11"/>
    <dbReference type="OMA" id="FVCWQAD"/>
    <dbReference type="PhylomeDB" id="Q9ZBW9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Heme</name>
            <dbReference type="ChEBI" id="CHEBI:17627"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
            <note>axial binding residue</note>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA22235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="4GT2"/>
        </source>
    </evidence>
    <sequence length="445" mass="47025" checksum="D5124E7B51E97730" modified="1999-05-01" version="1">MPDQSIPQTRSPEATRGTPGPLDSDNPGAATAPQGVSRRRLLGTAGATGLVLGAAGAAAGYAAAPSSAATPLTSLGSERAMFHGKHQPGITTPMQARGHLVAFDLAAGAGRKEAAALLRRWSDTARRLMAGEPAGSRDTDVARDAGPSSLTVTFGFGHSFFGRTGLEEQRPVALDPLPDFSSDHLDKNRSNGDLWVQIGADDALVAFHALRAIQRDAGAAARVRWQMNGFNRSPGATAHPMTARNLMGQVDGTRNPKPGEADFDRRIFVPEEPEAGKGGPAWMANGSYVVVRRIRMLLDDWEELSLKAQEDVIGRRKSDGAPLSGGSGATESTEMDLEKTDGSGELVVPINAHARITRPDQNGGAAMVRRPFSYHDGFDADGVPDAGLLFVCWQADPLRGFVPVQRKLDRGDALSQFIRHEASGLFAVPGGAAEGEYVGQRLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZC16</accession>
    <name>Q9ZC16_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transketolase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6497</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34727">
        <property type="entry name" value="T34727"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630579.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030966.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6497"/>
    <dbReference type="GeneID" id="1101936"/>
    <dbReference type="KEGG" id="sco:SCO6497"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6598"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_3_1_11"/>
    <dbReference type="InParanoid" id="Q9ZC16"/>
    <dbReference type="OMA" id="LTRAHDF"/>
    <dbReference type="PhylomeDB" id="Q9ZC16"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="305"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA22034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="615" mass="65377" checksum="C4DC418F65DC5391" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O54118</accession>
    <name>O54118_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5922</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34594">
        <property type="entry name" value="T34594"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630040.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973098.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5922"/>
    <dbReference type="GeneID" id="1101364"/>
    <dbReference type="KEGG" id="sco:SCO5922"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6020"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_14_1_11"/>
    <dbReference type="InParanoid" id="O54118"/>
    <dbReference type="OMA" id="GNTARYR"/>
    <dbReference type="PhylomeDB" id="O54118"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="326" mass="35276" checksum="CB8F3D5B218B0EB9" modified="1998-06-01" version="1">MSNEDITRQTTENTEQAGPKGPLAGRIALVAGATRGAGRAQAVELGRAGATVYVTGRTTRARASEVGRTTETIEETAELVTAAGGTGIAVPTDHLDEAQVRALVERIDREYERLDILVNDLWGGEHLLATSVFGKKSWETPLADGLRILELGARSHVITAALLLPLLIRSDAPLHVEVTDGTAHSNRRYRENIYYDLAKNAPIRLAFGLAQELAEYEGTAVAVSPGFLRSEQMLSHFGVSEENWRDAIAQEPTFAIAESPHYLARTVAALAADPDRAKRWNGKSTSSGELARAYGVTDVDGSRPDAWAYFEDVTYGGKEASPDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O54124</accession>
    <name>O54124_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5928</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34600">
        <property type="entry name" value="T34600"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630046.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030537.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101370"/>
    <dbReference type="KEGG" id="sco:SCO5928"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6025"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085660_0_0_11"/>
    <dbReference type="InParanoid" id="O54124"/>
    <dbReference type="OMA" id="TRPGPFW"/>
    <dbReference type="PhylomeDB" id="O54124"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="25231" checksum="03AEB58602C38F18" modified="1998-06-01" version="1">MMNDDDPALDDPVGQSLSGRHAHLARRFGRAATYLTDVATFSSVSVDPDAEDWADLAGLLGPGAFADMFSSPAVPPPGWEPVFSLEGRQMTWPGDGRPGRTRSASDTDVVELGADSVPEMLDLAARTEPGPFWPRTHELGTYLGVRVDGTLVAMAGERLRPPGWTEISAVCAAPEARGQGYAARLVRALTERISARGDRPFLHVAEANTGAIALYERLGFKTRRPVTFRGFRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O54136</accession>
    <name>O54136_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-transporter ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5870</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34822">
        <property type="entry name" value="T34822"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629992.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973151.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5870"/>
    <dbReference type="GeneID" id="1101312"/>
    <dbReference type="KEGG" id="sco:SCO5870"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5969"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="O54136"/>
    <dbReference type="OMA" id="VHARGMT"/>
    <dbReference type="PhylomeDB" id="O54136"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="24787" checksum="3793A7D9CD1D22DB" modified="1998-06-01" version="1">MTQVVTETMVRVEDVRKSYGRDSAAVHALRGVSFDVPRGELIALKGRSGSGKTTLLNIVGGLDTPDAGRVEVDGRDLAELDEDGLLALRRDRVGFVFQSFGLIPILTAAENVGVPMRLRRAAAREREERVELLLSLVGLADHAAQRPGEMSGGQQQRVAIARALANNPALLIADEPTGQLDAETGHSVMELLRAVVRSEQVTALVATHDATLLDLADRVLELRDGEIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-05-25" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>O54137</accession>
    <name>O54137_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO5871</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34823">
        <property type="entry name" value="T34823"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030507.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5871"/>
    <dbReference type="GeneID" id="1101313"/>
    <dbReference type="KEGG" id="sco:SCO5871"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5970"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_1_11"/>
    <dbReference type="InParanoid" id="O54137"/>
    <dbReference type="OMA" id="DMPVGDH"/>
    <dbReference type="PhylomeDB" id="O54137"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="620"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="848" mass="90863" checksum="FF7E0DB4E785A803" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-06-02" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>O69818</accession>
    <name>O69818_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6424</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28694">
        <property type="entry name" value="T28694"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030906.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6424"/>
    <dbReference type="GeneID" id="1101863"/>
    <dbReference type="KEGG" id="sco:SCO6424"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6524"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_6_11"/>
    <dbReference type="InParanoid" id="O69818"/>
    <dbReference type="PhylomeDB" id="O69818"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="137"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA18911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="331" mass="35438" checksum="EE17031DEAD9A872" modified="1998-08-01" version="1">MARVPDAAAVPLFWRISLFNSVVLIAATALLLGPVTVSTPVLLTEAAILTAGLVVILIANILLLRIGFGPLRQLARAMTTTDLLRPRVRPKVDGDGEIAELITTFNTMLDRLEAERALSAARTLSAQESERHRVAQELYDEVGQTLAAVLLDLKRVADQAPEEVREQLSQVQETTRASLDEIRRIARRLLPGVLEELGLSSALRSLSDEFTGPSLTVRHDIATGLPGLGDNADLVLYRVAQEGLTNAARHSGARLVVLSLERAGDAVRLRVRDDGRGFDDSGGAVEGAGIRGMRERALLIGADLVVGPARGGGTEVRLTVPVGDRVPDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O69824</accession>
    <name>O69824_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAA18917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T28700"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO6430"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6530"/>
    <dbReference type="eggNOG" id="COG2814">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434069_0_0_11"/>
    <dbReference type="InParanoid" id="O69824"/>
    <dbReference type="OMA" id="SFIELVP"/>
    <dbReference type="PhylomeDB" id="O69824"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="307"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    </feature>
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        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA18917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="630" mass="63959" checksum="28DE36D51D5AC7F7" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O69844</accession>
    <name>O69844_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cationic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6014</name>
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    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T34694"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972907.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6014"/>
    <dbReference type="GeneID" id="1101456"/>
    <dbReference type="KEGG" id="sco:SCO6014"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6113"/>
    <dbReference type="eggNOG" id="COG0531">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_7_11"/>
    <dbReference type="InParanoid" id="O69844"/>
    <dbReference type="OMA" id="PDNWRIP"/>
    <dbReference type="PhylomeDB" id="O69844"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <end position="50"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="207"/>
        </location>
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        <location>
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            <end position="263"/>
        </location>
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            <end position="308"/>
        </location>
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            <end position="351"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="503" mass="53532" checksum="7F9BA0804E55C425" modified="1998-08-01" version="1">MSNTLFRTKKIEQSIRDTEEPEHALKKSLSALDLTVFGIGVVIGTGIFVLTGTVAKDNAGPATALAFVVAGVVCALAALCYAEFASSVPVAGSAYTFSYASLGELPAWIIGWDLVLEFALGTAVVAVGWSGYIRSLMDNAGWHMPAELGGRDGAEGFGFDILAAALVLVLTAVLVLGMKLSARITSLVVAIKVAVVLIVIIAGAFFVKSANYDPFIPKSQPVEAGGGLHSPLIQLMFGWAPSNFGVMGIFTAASVVFFAFIGFDIVATAAEETRNPQRDMPRGILGSLIICTLLYVGVSIVVTGMQHYTKLSVDAPLADAFKATGHPFFSGVISFGAAVGLTTVCMILLLGQSRVFFAMSRDGLLPRFFSHVHPKFRTPYRPTILLGVIIAIVAGFTSLSELAELVNIGTLFAFVVVAISVIILRRTRPDLPRAFRTPLVPLLPIVSVAASLWLMLNLPAETWVRFAIWMAIGFVVYFLYGRTHSRLARGEEAPADPAEPSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O69849</accession>
    <name>O69849_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6019</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34699">
        <property type="entry name" value="T34699"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630130.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972904.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6019"/>
    <dbReference type="GeneID" id="1101460"/>
    <dbReference type="KEGG" id="sco:SCO6019"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6118"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063456_0_0_11"/>
    <dbReference type="OMA" id="CTVLAHR"/>
    <dbReference type="PhylomeDB" id="O69849"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="373" mass="39303" checksum="80405EB84CE7216E" modified="1998-08-01" version="1">MRTGSGRGAARGRAAGQVVEAGREQQVAEGCLDGRWLVLGKDGRLTAYARSRAGLLRWTETRPGGPHWSEPDLIPVPDLTDLSVTQGADTYVHFLGRRARGGDGAPPTVDVVHAIQYQTARPVTEWRSLGNPHPQQEKAARLGAPVAAVSSTGRVHVIVRNAGGGLMLRREGPSGRWDRWLDLKGSGVRDGFATTVHSSGRIEVLADSSQHAMRWWQSEADGDFGREPNIPLRITPGTASLLETAPDRSTFYWADGDTGQIVAHRLGGWVIPLGGASTGDRIAVLRAVLDGYDCTVLAHRGLDGEVMVAACGTENEGAGVWWSPAGGPSAGAPALALDGHGRIVLALIGPDGTLRVARQGAGPGLALDPPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O69946</accession>
    <name>O69946_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6571</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2008" name="Protein Pept. Lett." volume="15" first="709" last="712">
            <title>Crystal structure of SCO6571 from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Begum P."/>
                <person name="Sakai N."/>
                <person name="Hayashi T."/>
                <person name="Gao Y.G."/>
                <person name="Tamura T."/>
                <person name="Watanabe N."/>
                <person name="Yao M."/>
                <person name="Tanaka I."/>
            </authorList>
            <dbReference type="PubMed" id="18782066"/>
            <dbReference type="DOI" id="10.2174/092986608785133636"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34928">
        <property type="entry name" value="T34928"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630651.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972408.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="PDB" id="2ZDS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-332"/>
    </dbReference>
    <dbReference type="PDBsum" id="2ZDS"/>
    <dbReference type="SMR" id="O69946"/>
    <dbReference type="STRING" id="100226.SCO6571"/>
    <dbReference type="GeneID" id="1102010"/>
    <dbReference type="KEGG" id="sco:SCO6571"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6676"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_11"/>
    <dbReference type="InParanoid" id="O69946"/>
    <dbReference type="OMA" id="VDCKEAR"/>
    <dbReference type="PhylomeDB" id="O69946"/>
    <dbReference type="EvolutionaryTrace" id="O69946"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2ZDS"/>
        </source>
    </evidence>
    <sequence length="332" mass="37615" checksum="E7A1119EAE090E6E" modified="1998-08-01" version="1">MPRNFTLFTGQWADLPLEEVCRLARDFGYDGLELACWGDHFEVDKALADPSYVDSRHQLLDKYGLKCWAISNHLVGQAVCDAIIDERHEAILPARIWGDGDAEGVRQRAAAEIKDTARAAARLGVDTVIGFTGSAIWHLVAMFPPAPESMIERGYQDFADRWNPILDVFDAEGVRFAHEVHPSEIAYDYWTTHRALEAVGHRPAFGLNFDPSHFVWQDLDPVGFLWDFRDRIYHVDCKEARKRLDGRNGRLGSHLPWGDPRRGWDFVSAGHGDVPWEDVFRMLRSIDYQGPVSVEWEDAGMDRLQGAPEALTRLKAFDFEPPSASFDAAFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O86526</accession>
    <name>O86526_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29075">
        <property type="entry name" value="T29075"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629679.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5545"/>
    <dbReference type="GeneID" id="1100985"/>
    <dbReference type="KEGG" id="sco:SCO5545"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5633"/>
    <dbReference type="eggNOG" id="ENOG502ZMXD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208638_0_0_11"/>
    <dbReference type="OMA" id="FRNIANP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="58" mass="6502" checksum="6F5EB32BDAEEE3D9" modified="1998-11-01" version="1">MMFHKIANPRRTTLAHLQDADELRTPEQPEHAVELPAQTANPRRTILMEAPVTASVAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-08-03" version="146" xmlns="http://uniprot.org/uniprot">
    <accession>P40173</accession>
    <accession>Q9L0K3</accession>
    <name>EFG1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor G 1</fullName>
            <shortName>EF-G 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fusA</name>
        <name type="synonym">fus</name>
        <name type="ordered locus">SCO4661</name>
        <name type="ORF">SCD840A.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Biochim. Biophys. Acta" volume="1219" first="543" last="547">
            <title>Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="van Wezel G.P."/>
                <person name="Woudt L.P."/>
                <person name="Vervenne R."/>
                <person name="Verdurmen M.L."/>
                <person name="Vijgenboom E."/>
                <person name="Bosch L."/>
            </authorList>
            <dbReference type="PubMed" id="7918656"/>
            <dbReference type="DOI" id="10.1016/0167-4781(94)90085-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 616-708</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X77039">
        <property type="protein sequence ID" value="CAA54328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S50137">
        <property type="entry name" value="S50137"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974302.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40173"/>
    <dbReference type="SMR" id="P40173"/>
    <dbReference type="STRING" id="100226.SCO4661"/>
    <dbReference type="GeneID" id="1100102"/>
    <dbReference type="KEGG" id="sco:SCO4661"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4732"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_11"/>
    <dbReference type="InParanoid" id="P40173"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="PhylomeDB" id="P40173"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091227" description="Elongation factor G 1">
        <location>
            <begin position="1"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="708" mass="77657" checksum="36602998061D3B1B" modified="2001-10-18" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>P40181</accession>
    <accession>Q9S2L8</accession>
    <name>Y2128_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO2128</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2128</name>
        <name type="ORF">SC6E10.22c</name>
        <name type="ORF">SC6G10.01c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="Mol. Microbiol." volume="6" first="2833" last="2844">
            <title>The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression.</title>
            <authorList>
                <person name="Angell S."/>
                <person name="Schwarz E."/>
                <person name="Bibb M.J."/>
            </authorList>
            <dbReference type="PubMed" id="1435260"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1992.tb01463.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-390</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAD55294" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55294.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X65932">
        <property type="protein sequence ID" value="CAA46725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35509">
        <property type="entry name" value="T35509"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733559.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976687.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028153.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40181"/>
    <dbReference type="SMR" id="P40181"/>
    <dbReference type="STRING" id="100226.SCO2128"/>
    <dbReference type="GeneID" id="1097562"/>
    <dbReference type="KEGG" id="sco:SCO2128"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2163"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_1_0_11"/>
    <dbReference type="InParanoid" id="P40181"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152265" description="Uncharacterized protein SCO2128">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="390" mass="41221" checksum="0D95BE1AFEA6EAD8" modified="2000-12-01" version="2">MRTLLITGPGGTGRTTVAAATALTAARQGTRTLVLGTDRDDTLGAALGVRTGPAPTSVEPGLTAWRPDAAQGFRDALAALQDRAASALDLLGAARLDPQELTPLPGADDLALLRALREAALAEAHDLLVVDLPPAPRALALLAAPEELRRALRRLLPPERQAARALRPVLGRLAGVPMPTEALYEAAARWDLELAAAESVLADRNTVVRLVAEPGPAGADAVRTTTLGLALRGLRTDLLVANRVLPEDTPADSWLSGPLAQQRKTLEEWRGAYDVRAVAHLGHDPRGTDDLAALAVPGVNPDASPVEWPVTDRLAEDGVLVWHIPLPGAVREELDLVRRGDELAVAAGPFRRTVPLPSALRRCTVDGAALRDGTLAVRFAPDPELWPRGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>P57755</accession>
    <name>GLSA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaminase</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glsA</name>
        <name type="ordered locus">SCO7049</name>
        <name type="ORF">SC4G1.15</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631111.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031401.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P57755"/>
    <dbReference type="SMR" id="P57755"/>
    <dbReference type="STRING" id="100226.SCO7049"/>
    <dbReference type="GeneID" id="1102487"/>
    <dbReference type="KEGG" id="sco:SCO7049"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7153"/>
    <dbReference type="eggNOG" id="COG2066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027932_1_1_11"/>
    <dbReference type="InParanoid" id="P57755"/>
    <dbReference type="OMA" id="RPRNPFI"/>
    <dbReference type="PhylomeDB" id="P57755"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000110627" description="Glutaminase">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <sequence length="307" mass="32556" checksum="CCF51DFAE88D2079" modified="2001-01-24" version="1">MSTPTTFRPVLERIAEEIERTPGSGRPADYIPALAARDPRRFGMAVAELDGTVYGVGDWREPFSAQSLTKVFTLALDLAREGDALWEHVGREPSGNPFNSLVQLEYENGIPRNPFINAGALVVTDRLHTRTGDAAGELLAFLRAESGNPDLGHDEEVAASEAAHGDRNAALAHFMASYGNIDNPVPVLLDQYFRQCSVAASCADLALATGFLARHGIRADGTRLLSRSRAKQINAVMLTCGTYDAAGDFAHRVGLPGKSGVGGGIIAVVPGHCTLCVWGPGLDERGNSVAGVAALDRFTTLTGLSVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q02062</accession>
    <name>ACTI2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Actinorhodin polyketide putative beta-ketoacyl synthase 2</fullName>
            <ecNumber>2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>actI ORF2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5088</name>
        <name type="ORF">SCBAC28G1.14</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="19278" last="19290">
            <title>Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.</title>
            <authorList>
                <person name="Fernandez-Moreno M.A."/>
                <person name="Martinez E."/>
                <person name="Boto L."/>
                <person name="Hopwood D.A."/>
                <person name="Malpartida F."/>
            </authorList>
            <dbReference type="PubMed" id="1527048"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="miscellaneous">
        <text>This putative ketoacyl synthase lacks the active site cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-"/>
    <dbReference type="EMBL" id="X63449">
        <property type="protein sequence ID" value="CAA45044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S25841">
        <property type="entry name" value="S25841"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629238.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030048.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="PDB" id="1TQY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="B/D/F/H=2-407"/>
    </dbReference>
    <dbReference type="PDBsum" id="1TQY"/>
    <dbReference type="AlphaFoldDB" id="Q02062"/>
    <dbReference type="SMR" id="Q02062"/>
    <dbReference type="IntAct" id="Q02062">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5088"/>
    <dbReference type="GeneID" id="1100529"/>
    <dbReference type="KEGG" id="sco:SCO5088"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5168"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="InParanoid" id="Q02062"/>
    <dbReference type="OMA" id="TDHMTRL"/>
    <dbReference type="PhylomeDB" id="Q02062"/>
    <dbReference type="EvolutionaryTrace" id="Q02062"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000180349" description="Actinorhodin polyketide putative beta-ketoacyl synthase 2">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="3"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="98"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="180"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="230"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="321"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="365"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="373"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="382"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="391"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="394"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="1TQY"/>
        </source>
    </evidence>
    <sequence length="407" mass="42550" checksum="59FC75A5A0D94632" modified="1995-02-01" version="1">MSVLITGVGVVAPNGLGLAPYWSAVLDGRHGLGPVTRFDVSRYPATLAGQIDDFHAPDHIPGRLLPQTDPSTRLALTAADWALQDAKADPESLTDYDMGVVTANACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGMRGPSSALVAEQAGGLDALGHARRTIRRGTPLVVSGGVDSALDPWGWVSQIASGRISTATDPDRAYLPFDERAAGYVPGEGGAILVLEDSAAAEARGRHDAYGELAGCASTFDPAPGSGRPAGLERAIRLALNDAGTGPEDVDVVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLYSGGGPLDVVTALMSLREGVIAPTAGVTSVPREYGIDLVLGEPRSTAPRTALVLARGRWGFNSAAVLRRFAPTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q05558</accession>
    <accession>Q9KYQ2</accession>
    <name>DNAK_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dnaK</name>
        <name type="ordered locus">SCO3671</name>
        <name type="ORF">SCH44.11c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Gene" volume="130" first="141" last="144">
            <title>Cloning and sequencing of the dnaK region of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bucca G."/>
                <person name="Smith C.P."/>
                <person name="Alberti M."/>
                <person name="Seidita G."/>
                <person name="Passantino R."/>
                <person name="Puglia A.M."/>
            </authorList>
            <dbReference type="PubMed" id="8344522"/>
            <dbReference type="DOI" id="10.1016/0378-1119(93)90358-A"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="DNA Seq." volume="6" first="179" last="184">
            <title>Cloning and sequencing of the dnaK locus in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Brans A."/>
                <person name="Loriaux A."/>
                <person name="Joris B."/>
                <person name="Dusart J."/>
            </authorList>
            <dbReference type="PubMed" id="8722574"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="L46700">
        <property type="protein sequence ID" value="AAB29451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X77458">
        <property type="protein sequence ID" value="CAA54606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAD55329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JN0830">
        <property type="entry name" value="JN0830"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733614.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975268.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q05558"/>
    <dbReference type="SMR" id="Q05558"/>
    <dbReference type="STRING" id="100226.SCO3671"/>
    <dbReference type="PRIDE" id="Q05558"/>
    <dbReference type="GeneID" id="1099107"/>
    <dbReference type="KEGG" id="sco:SCO3671"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3729"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_11"/>
    <dbReference type="InParanoid" id="Q05558"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="PhylomeDB" id="Q05558"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000078550" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="618" mass="66270" checksum="3735D39BD14A0511" modified="1994-02-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKF5</accession>
    <name>Q7AKF5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation transcription factor, WhiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5819</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35193">
        <property type="entry name" value="T35193"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629942.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030477.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5819"/>
    <dbReference type="GeneID" id="1101261"/>
    <dbReference type="KEGG" id="sco:SCO5819"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5913"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_11"/>
    <dbReference type="OMA" id="IIEWRAF"/>
    <dbReference type="PhylomeDB" id="Q7AKF5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="31916" checksum="1C6733055800AB04" modified="2012-05-16" version="1">MSTLAHTMMTAARSADSGLANPGELDRYPYAETPAVDRLGAPSWEGVEPELGRVGRRTAGNRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVSDWNLLDPDIIEWRAFGPQRDDQRRELSELRWTIEPLAARLAAGHGREDVQQRLSDMVGIMGHAMGQGDGLTFSRADTEFHTLLIQIAGNRMLDHLSGIVSAALHVSGGPVTGCDRPNDVSIAQHGRIVDALATGDGAAAEAAMRQLLTVHPEVERVVPAPREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKJ7</accession>
    <accession>Q7B0B2</accession>
    <name>Q7AKJ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DmdR1 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Iron repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dmdR1</name>
        <name evidence="9" type="ordered locus">SCO4394</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2000-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Flores Delgado F.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">A3</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and analysis of dmdR genes.</title>
            <authorList>
                <person name="Flores F.J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">A3</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">A3</strain>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ271797">
        <property type="protein sequence ID" value="CAC28070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974588.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4394"/>
    <dbReference type="GeneID" id="1099834"/>
    <dbReference type="KEGG" id="sco:SCO4394"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4462"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_0_11"/>
    <dbReference type="OMA" id="DAQLMYT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040767">
        <property type="entry name" value="DtxR_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18357">
        <property type="entry name" value="DtxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB95905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC28070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="25191" checksum="D9D6F9AEBA4A17A6" modified="2004-07-05" version="1">MSGLIDTTEMYLRTILELEEEGVVPMRARIAERLDQSGPTVSQTVARMERDGLVSVAADRHLELTDEGRRLATRVMRKHRLAECLLVDVIGLEWEQVHAEACRWEHVMSEAVERRVLELLRHPTESPYGNPIPGLEELGETDGADPFLDEGMVSLADLDPGQEGKTVVVRRIGEPIQTDAQLMYTLRRAGVQPGSVVSVTESAGGVLVGSGGEAAELEADTASHVFVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK19</accession>
    <name>Q8CK19_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO1761</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAD55177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36864">
        <property type="entry name" value="T36864"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733544.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027959.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1761"/>
    <dbReference type="GeneID" id="1097192"/>
    <dbReference type="KEGG" id="sco:SCO1761"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1779"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_1_1_11"/>
    <dbReference type="InParanoid" id="Q8CK19"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="PhylomeDB" id="Q8CK19"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD55177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="361" mass="37860" checksum="44B0F1C3BCF5308F" modified="2003-03-01" version="1">MRTALVIGTGLIGTSAALALTERGVTVHLADHDPEQARTAAALGAGTDEAPDGPVDLAVVAAPPALVADVLADAMARGLARGYIDVASVKGGPRRELEARGLDLSAYIGTHPMSGREKSGPLAATADLFEGRPWVLTPTRDTDTEVLNLALELVSHCRAVPVVMDADAHDRAVALVSHMPHLVSSMVAARLEHAEEAAVRLCGQGIRDVTRIAASDPRMWIDILSANPGPVADLLTDVAADLEETVRALRALQSTDEDKRREGGTGIAEVLRRGNAGQVRVPGKHGSAPRSYETVAVLIDDQPGQLARIFADAGRAGVNVEDVRIEHATGQQAGLVQLMVEPKAAAVLTAALKERGWAIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK31</accession>
    <name>Q8CK31_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1359</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAD55171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733531.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027745.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1359"/>
    <dbReference type="GeneID" id="1096782"/>
    <dbReference type="KEGG" id="sco:SCO1359"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1367"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_2_11"/>
    <dbReference type="InParanoid" id="Q8CK31"/>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="PhylomeDB" id="Q8CK31"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="165"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="34545" checksum="DBBC2D843F3D0DEB" modified="2003-03-01" version="1">MSSVPSPSAPSPARRVLDWRLRFGLLSLVWGFSFLFMKVGTESFAPFQVTLGRLAFGTAVVAAAMAVKRERLPRGAWTWLHLTVAGFLLNALPFSLFAFSELTIPSSLAGICNATSPLWGMALSLVALSEDRPTRRRVAGLGIGFLGVLTVLGVWQGFHGLDVTGTALALLASFSYPVGWIYVRRTLAGSSHSHLSLTGAQLGLATLQLAVVTPLFTSVPTSFPVLPLLAVAALGVLGTGLAFLIQYDLVAEVGPTTAQMVTYFTPVIATAAGVALLGESLSWSTPVGAAVVLAGAALTQSRPRADRAAPAPAPAPAPETPGTTGVRQGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J02</accession>
    <name>Q93J02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7518</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2006-03" db="PDB data bank">
            <title>Crystal structure of the putative transcriptional regulator SCO7518 from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Hayashi T."/>
                <person name="Watanabe N."/>
                <person name="Tanaka Y."/>
                <person name="Sakai N."/>
                <person name="Tamura T."/>
                <person name="Yao M."/>
                <person name="Tanaka I."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.21 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031717.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="PDB" id="2DG8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.21 A"/>
        <property type="chains" value="A/B/C/D=1-185"/>
    </dbReference>
    <dbReference type="PDBsum" id="2DG8"/>
    <dbReference type="SMR" id="Q93J02"/>
    <dbReference type="MINT" id="Q93J02"/>
    <dbReference type="STRING" id="100226.SCO7518"/>
    <dbReference type="GeneID" id="1102956"/>
    <dbReference type="KEGG" id="sco:SCO7518"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7632"/>
    <dbReference type="eggNOG" id="COG3226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_21_2_11"/>
    <dbReference type="InParanoid" id="Q93J02"/>
    <dbReference type="OMA" id="SMTYHFD"/>
    <dbReference type="PhylomeDB" id="Q93J02"/>
    <dbReference type="EvolutionaryTrace" id="Q93J02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2DG8"/>
        </source>
    </evidence>
    <sequence length="185" mass="20877" checksum="2BBF4606A4F010EC" modified="2001-12-01" version="1">MATGHTDPQRRERILAATLDLIAEEGIARVSHRRIAQRAGVPLGSMTYHFTGIEQLLREAFGRFTDHIVAVFDEHLGAAADRDEAREAVADLVHELSEDSQRDLVLTQELYTLAARQPAYRELTHEWMRRSRVHLEKHFDPGTARQLDALIEGLTLHRALAREPHGRALTLEAIARITTTDRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J07</accession>
    <name>Q93J07_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7512</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC42139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631557.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031713.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7512"/>
    <dbReference type="GeneID" id="1102950"/>
    <dbReference type="KEGG" id="sco:SCO7512"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7625"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="InParanoid" id="Q93J07"/>
    <dbReference type="OMA" id="GYTPMQW"/>
    <dbReference type="PhylomeDB" id="Q93J07"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="34232" checksum="B3155E85171BCDC3" modified="2001-12-01" version="1">MPSPRLRRAAVLVLEGAKPLDVGIPAQVFTTRASMPYEVRVCGAAPGLVTGGDGLSYHVAHGLDALAWADLVFLPGYRSPDVEDPPRTVLDALTAAHDRGARLAAISTGAFALAATGLLDGRRATTHWHYTRALAAKHPGVRVDENVLFVDEGSVLTSAGAASGIDLCLHILRGDLGVAASNHAARRLVAAPYRSGGQAQYVPRSVPEPLGERFAATREWALRRLGEPLTLETLARHAAVSARTLSRRFVEDTGYTPMQWVMRARIDLARELLERSERGVEQIAAEAGLGTGANLRLHFQRILGTTPSEYRRTFARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J41</accession>
    <name>Q93J41_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3965</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628148.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029345.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDBsum" id="3ZJA"/>
    <dbReference type="PDBsum" id="3ZK0"/>
    <dbReference type="SMR" id="Q93J41"/>
    <dbReference type="STRING" id="100226.SCO3965"/>
    <dbReference type="GeneID" id="1099401"/>
    <dbReference type="KEGG" id="sco:SCO3965"/>
    <dbReference type="eggNOG" id="COG2847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100939_2_3_11"/>
    <dbReference type="InParanoid" id="Q93J41"/>
    <dbReference type="OMA" id="GNHLMFE"/>
    <dbReference type="PhylomeDB" id="Q93J41"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004321772" evidence="1">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="18391" checksum="9D9BD545B2C103D5" modified="2001-12-01" version="1">MRRLAEGPVRRLAGGPVRRRPALAAVAVIGALTLAGCGGSDSGADSASPGAELSVDAAYIPQPVSDSMAAGFLTITNEGDSADELTSVTSEAGEVTVHETIDGTMKEVDRIEVPAHGQLVFKSGGNHLMFEKLKQQPKQGQSVAVELHFAHSDPVAVKLPVKAATYQPTAGHSEDSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J97</accession>
    <name>Q93J97_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7500</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631546.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971645.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7500"/>
    <dbReference type="GeneID" id="1102938"/>
    <dbReference type="KEGG" id="sco:SCO7500"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7613"/>
    <dbReference type="eggNOG" id="COG1953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_0_2_11"/>
    <dbReference type="InParanoid" id="Q93J97"/>
    <dbReference type="OMA" id="GIQTMFG"/>
    <dbReference type="PhylomeDB" id="Q93J97"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC44678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="495" mass="53119" checksum="5B214A7466697172" modified="2001-12-01" version="1">MTALEDRRSSDRTGDTATSSGLYTYDLAPTKREGRRWGAYNVFTLWANDVHSLGNYAFAIGLFALGLNVWGILAAFALASVLLFLLLTLSGFMGHKTGVPFPVMSRIAFGIKGAKIPAAVRGAVAIAWFGIQTYLASAVLSALLVAMFPSLASLDTNSLLGQSTLGWITFLVLWALQVLIVSYGMQMIRRYMAFAAPTTLLTMCALAVWMFVRADGSVSVSVDAPLTGGAMWLQVLQAAALWVVIYGTFVLNFCDFTRSARSRGSIVRGNVIGIPVNMLFFAVIVAVLSGAQFTLDGRVITSPTDIVRTIPNMFLLAVASLCLIALTVAVNLLANFVAPIYALVNLFPHRLDFRRAGLVSAALGLVITPWNLYNSPVVVNYFLGGLGALLGPLFGVIMADYWLLRRSRVNVPALYTEDAGAEYHYRRGYNPRAVAAFAPAAAIAVVVALVPFFHAAAGFSWFVGAIIAAVLYALIADRASPFRDVDGESIAVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD77</accession>
    <name>Q9AD77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4933</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629086.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029958.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4933"/>
    <dbReference type="GeneID" id="1100374"/>
    <dbReference type="KEGG" id="sco:SCO4933"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5013"/>
    <dbReference type="eggNOG" id="ENOG5034647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170102_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323007" evidence="2">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="24957" checksum="388BC4428FEAA224" modified="2001-06-01" version="1">MLSKLPVSASRVVPSPVAVVAVVSVEASAEAALAWAVTCGDGFAAADSSTGVSGVAFADGTNHRAHSRPPAEAAVSKERRADDTEYRSPCGAGELAVWADVSERRGSQESHGSGRPYAPGMSTPETSRFVRIRVELVLEIDDEEAVTGAALQALADDTDLSDAERADSERAVTEDTAEALAHLVDPFDLVSVVPGVELQQASWSSEQIDYDPDSPEWDLDEDDGGENDPEDEEMTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADE7</accession>
    <name>Q9ADE7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5060</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629211.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030028.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5060"/>
    <dbReference type="GeneID" id="1100501"/>
    <dbReference type="KEGG" id="sco:SCO5060"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5139"/>
    <dbReference type="eggNOG" id="ENOG5033Y7D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091024_1_0_11"/>
    <dbReference type="OMA" id="RTRPAQY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC37448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="20702" checksum="4B4C5B37388A7244" modified="2001-06-01" version="1">MEQHRTRPAQYGPRRSGAPLPAQGRGGAVARPPAGRVGPPAGRRPEPVRPAPGAPSPVARVVRALRGMPNPRLTGLGSGLFCAAVMTLLGFLDELLFGSSLTAYGVLFVPVSLLTALWVRRGDLLTAPVVVPIAFAVGLVPVAESGDGGLGGRLMGIVTALATEAGWLYGGTLVAGSTVIVRRIRLMRRRAAAARNRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK13</accession>
    <name>Q9AK13_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7715</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631753.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031850.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7715"/>
    <dbReference type="GeneID" id="1103153"/>
    <dbReference type="KEGG" id="sco:SCO7715"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7837"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AK13"/>
    <dbReference type="OMA" id="RVWNYLL"/>
    <dbReference type="PhylomeDB" id="Q9AK13"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC22723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="28762" checksum="433C414DA02B6C72" modified="2001-06-01" version="1">MTDPREEAGARLQTDRPHSARVWNYLLGGKDNYPVDSEAGDVILTTFPEFAAVARLQRRFLARAVRFLAGEVGIRQFLDIGTGLPTADNTHELAQRIAPESRIVYVDNDPLVLTHARALLTSTPEGACAYVDADVRHPERILAEAARTLDLSRPVALTALGIMGQISDAERPAELLDTLMAALPRGSCLALSDGTDNNEALNRAVQVYNGQSANTYHLRSPQEIAAFLTGLDLVDPGVVATASWRPDAGRPEEPTADVSVCGVAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK60</accession>
    <name>Q9AK60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4057</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628239.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974906.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4057"/>
    <dbReference type="GeneID" id="1099493"/>
    <dbReference type="KEGG" id="sco:SCO4057"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4119"/>
    <dbReference type="eggNOG" id="COG0580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_3_11"/>
    <dbReference type="InParanoid" id="Q9AK60"/>
    <dbReference type="OMA" id="IPTHAIA"/>
    <dbReference type="PhylomeDB" id="Q9AK60"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="31905" checksum="8827F9BA004C0E19" modified="2001-06-01" version="1">MAERIVHRRGYRKGLGGEMCAEFLGTFVLILFGVGSVAVAVAGLPGSGRQTADFGPANWLIISWGWGLAVVFGVYVAGGISGAHLNPAVTLGFAVRRDFPWRKVLPYWLAQVVGAFVAAALVYACYRWAIDAAIAKAGETRETSLNTYSIFATFPAEYFGDSWWGPLLDQIVGTGILLLLICALIDTRNTAPMANLHPYLIGLVVVAIGLTFGTNAGYAINPARDFGPRLFTFFEGWGDIALPGTFQWFSGYWWIPIVGPLIGGVVGVLVYDLLVSPVLKARLTEREEGPATEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK63</accession>
    <name>Q9AK63_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4054</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628236.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029407.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1099490"/>
    <dbReference type="KEGG" id="sco:SCO4054"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4116"/>
    <dbReference type="eggNOG" id="ENOG5030EIV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093175_0_0_11"/>
    <dbReference type="OMA" id="EPYGRWL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="25240" checksum="C13D8696B40D2991" modified="2001-06-01" version="1">MLLILLALASAAACWLTFARWLPSDGERYQDYRAAEPCSSDALSRRDTDCLSTWHLTVQKTENRTAGKESVHDATVTYRDSWRRTVHLDGSGPLLERLVPGDRVTATAWRGEIMVLGKDGVRQDTLEAPRDELQMNAAAGVLAGLLAAQCLVFGVVRLVRPLDHEPLTWEPYGRWLLFGLVGVSFAVGLSAVWTGLPWGTVPLVAVPLAACVALWFRLRLRPRLRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK86</accession>
    <name>Q9AK86_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative lacI-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1376</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625660.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977450.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1376"/>
    <dbReference type="GeneID" id="1096799"/>
    <dbReference type="KEGG" id="sco:SCO1376"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1384"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9AK86"/>
    <dbReference type="OMA" id="SIIVNMD"/>
    <dbReference type="PhylomeDB" id="Q9AK86"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="356" mass="37791" checksum="E0D3539B24C262D2" modified="2001-06-01" version="1">MATDEARAETVSGRRGRVTITDIARRAGVSVPTVSRVVNGRSDVSPGTRARVEELLRRHGYRKRAAAPGRRAALIDLVFNDLDSPWAVEIIRGVEEVAHAAGVGTVVSAIHGRSGDARQWMRNLRARASDGVVVVTSALDPVLHQELRILGVPLVVVDPAGAPDLDVPIVGAANHSGGRAATEHLLALGHRRIGLIAGPPRLLCSRARRDGYRAALEDAGVAVDESLVVPGDFRHESGFAACATLLGLPEPPTAVFAASDQMALGAIEALRRRGLRVPQDMSVVGFDDLPEVRWSAPPLTTVRQPLADMGRQAARAVLRRTRGEPADPPRTELGTELIVRSSTAPPPPPVPATPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWD5</accession>
    <name>Q9EWD5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4872</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629026.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029918.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4872"/>
    <dbReference type="GeneID" id="1100313"/>
    <dbReference type="KEGG" id="sco:SCO4872"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4951"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063047_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWD5"/>
    <dbReference type="OMA" id="IHIDASH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="338" mass="36814" checksum="895D4A0E90586C42" modified="2001-03-01" version="1">MATAQETHEYPGELNDVPGWFWPLDQVLFSWFLERQERLDTRGDLLELGAYLGKSAILLGHRLRDGEKLTVCDLFGAQPPDAANRAEAAKSYSSLTRQAFERNYLSFHDTLPTIIQAPSSAVVGEVAPGSCRFVHVDASHLYEHVEGDIGAAKELLGPDGIVVLDDFRSEHTPGVAVAAWEAVLNRGLRPVCLSSQKLYGTWGDPEPVREELIAAFRGRDDIAVTVEQAAGHRLVRTRAKVKRLRPPSLPSSRHPAPVPSPEAGRTDAAPVPEQAPQPRPARPAARTARPSARRDRTRKLALDLLPPLVTRAVRRYLAAQRAKAGGAGRAAGAAQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWP1</accession>
    <name>Q9EWP1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-09" db="PDB data bank">
            <title>Crystal Structure of CYP105N1 from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Zhao B."/>
                <person name="Waterman M.R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH HEME</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2012" name="Arch. Biochem. Biophys." volume="528" first="111" last="117">
            <title>Crystal structure of cytochrome P450 CYP105N1 from Streptomyces coelicolor, an oxidase in the coelibactin siderophore biosynthetic pathway.</title>
            <authorList>
                <person name="Lim Y.R."/>
                <person name="Hong M.K."/>
                <person name="Kim J.K."/>
                <person name="Doan T.T."/>
                <person name="Kim D.H."/>
                <person name="Yun C.H."/>
                <person name="Chun Y.J."/>
                <person name="Kang L.W."/>
                <person name="Kim D."/>
            </authorList>
            <dbReference type="PubMed" id="23000034"/>
            <dbReference type="DOI" id="10.1016/j.abb.2012.09.001"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH HEME</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631725.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031831.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="PDB" id="3TYW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A/B/C/D=1-411"/>
    </dbReference>
    <dbReference type="PDB" id="4FXB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A/B=1-411"/>
    </dbReference>
    <dbReference type="PDBsum" id="3TYW"/>
    <dbReference type="PDBsum" id="4FXB"/>
    <dbReference type="SMR" id="Q9EWP1"/>
    <dbReference type="STRING" id="100226.SCO7686"/>
    <dbReference type="GeneID" id="1103124"/>
    <dbReference type="KEGG" id="sco:SCO7686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7807"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_1_11"/>
    <dbReference type="InParanoid" id="Q9EWP1"/>
    <dbReference type="OMA" id="DFHRTDN"/>
    <dbReference type="PhylomeDB" id="Q9EWP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036199">
        <property type="term" value="F:cholest-4-en-3-one 26-monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC17503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3TYW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="4FXB"/>
        </source>
    </evidence>
    <sequence length="411" mass="45100" checksum="7E6F07608BC09B5D" modified="2001-03-01" version="1">MTPPESPTASHTPGATPPRDFPIQRGCPFAAPAEYAALRTDDPVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVSTSVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRDDLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKDPDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVVVKHDSATFGLEELMVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWQ6</accession>
    <name>Q9EWQ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7671</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631710.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7671"/>
    <dbReference type="GeneID" id="1103109"/>
    <dbReference type="KEGG" id="sco:SCO7671"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7790"/>
    <dbReference type="eggNOG" id="COG3424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_0_1_11"/>
    <dbReference type="InParanoid" id="Q9EWQ6"/>
    <dbReference type="OMA" id="GPAFCSE"/>
    <dbReference type="PhylomeDB" id="Q9EWQ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="4">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC17488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="42469" checksum="5E9CDE076AC92903" modified="2001-03-01" version="1">MNDMRVPVLVEHAPSPSAPASVARRPPPPSAAGPRIAAVRCALPPHRYAQHELTGPIGDLCLSPGADRALLHRVHASAGVRTRHLALPIERYARLGDFGRSNGAWLETGLELGEEALSGALREAGLTPADVDLLVFASITGVSAPSLDARLAGRMGLRPDVKRLPLFGLGCVAGAAGLARVHDHLRGHPEDTAVLLTVELCSLTLQRGDASRANLVAGALFGDGAAALVARGGNTDGVNTDDGGSGSGSGSGSGSGSGSGSGTVAPASGPRVVATRSHLYPGTEGLLGWEIGAAGFRVVIDAGVPDIVRGHFGRHLRAFLAEHELTVDDIGTWICHPGGPRILSAVSETLGLSEDALDRSRRSLAAVGNMSSVSVLHILEDVRARRAPEPGTWGLLLAMGPGFCSELVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2J8</accession>
    <name>Q9F2J8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3783</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627973.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029231.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099219"/>
    <dbReference type="KEGG" id="sco:SCO3783"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3843"/>
    <dbReference type="HOGENOM" id="CLU_208623_0_0_11"/>
    <dbReference type="OMA" id="FRTAERY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176656" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC10321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="58" mass="5667" checksum="13A88D1BEBBBC743" modified="2001-03-01" version="1">MPVRFRTAERYARALTAAVAAVACLLLAANAGPADTAPSPAPAPEAAPPEDGPAPADG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F309</accession>
    <name>Y2625_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uncharacterized N-acetyltransferase SCO2625</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2625</name>
        <name type="ORF">SCC80.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text>Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAC10001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028461.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F309"/>
    <dbReference type="SMR" id="Q9F309"/>
    <dbReference type="STRING" id="100226.SCO2625"/>
    <dbReference type="GeneID" id="1098059"/>
    <dbReference type="KEGG" id="sco:SCO2625"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2671"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F309"/>
    <dbReference type="OMA" id="WNEGRWR"/>
    <dbReference type="PhylomeDB" id="Q9F309"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034069">
        <property type="term" value="F:aminoglycoside N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030649">
        <property type="term" value="P:aminoglycoside antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000220266" description="Uncharacterized N-acetyltransferase SCO2625">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="1">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <sequence length="413" mass="44719" checksum="29869DA00AD7AB0A" modified="2001-03-01" version="1">MTMEPRVLRREEWDSWYGSLIRAFGGVPEPAEELELFRELTRVDRSIGVWERDGEAEACVGTTGSFDFRMTVPGGAQVRAAGVTMVSVAATHRRRGVLTSMMRRQLDDVRAWGEPLAVLTASEPAIYGRFGYGAATFSLSAEIDTSRVRLSVPAGTDDVRLRYAAPADVLDACEAVYARLVPGRPGMLARRPGWERLALLDPESGRDGASPLQCVVARRGGEVTGFARFRVRPAWGPEGAGGTVVLDDLAGLDPATEAALWRFLYDVDLTSRLAVRGRPVDEAWQYQVSDIRRCRPESRDALYVRLVDVGAALAARTYQAPVDVVFEVEDAFCPWNAGRWRLSGDAKGASCERTSDGADLALSVRELGAAYLGGVRLSSLGAAGRVREVRAGALAEASVGFGSDVAPWLPHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L6</accession>
    <name>Q9F3L6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629394.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030135.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5248"/>
    <dbReference type="GeneID" id="1100689"/>
    <dbReference type="KEGG" id="sco:SCO5248"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5332"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079355_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F3L6"/>
    <dbReference type="OMA" id="CRHHGWT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="21167" checksum="1DDDE09CAF9F7755" modified="2001-03-01" version="1">MSASSFLKALKAEGLTVVQVGDWRDHNRNHKGPWGPVHGVMIHHTVTKGSARTVDICRKGYEGLPGPLCHGVVTKDGKVHLVGYGRANHAGLGDDDVLRAVIAEKALPRDNEANTDGNRHFYGFECENLGDGDDPWPAAQLEAIERAAAAVCRHHGWNERSVIGHLEWQPGKVDPRGFTMTSMRNRIRDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBS4</accession>
    <name>Q9FBS4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7168</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631227.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971974.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7168"/>
    <dbReference type="GeneID" id="1102606"/>
    <dbReference type="KEGG" id="sco:SCO7168"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7269"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_5_11"/>
    <dbReference type="InParanoid" id="Q9FBS4"/>
    <dbReference type="OMA" id="CEASANP"/>
    <dbReference type="PhylomeDB" id="Q9FBS4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC01657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24126" checksum="3D188102E2390E3D" modified="2001-03-01" version="1">MAGVGEPLTRVLLSDQVYTRVRGLIVNGDLKAGDRLVEAEIARDLGVSQAPVREAVKRLVHEGLADHIPRRGSFVADVSSQDADAARAVRVIIEEFAARAVAERADPESVDALRAKVQDMREAAEAGDIGRFRDADIAFHRILCEASANPFLSRIWSLMEPSLRALRVVSDPMFTGDWAEMAVQHGVLLETLESADADRAAAAFAAHARGDEGVLGHGHDHGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBZ6</accession>
    <name>Q9FBZ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7186</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631244.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031491.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7186"/>
    <dbReference type="GeneID" id="1102624"/>
    <dbReference type="KEGG" id="sco:SCO7186"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7285"/>
    <dbReference type="eggNOG" id="ENOG5031UNG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2384930_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="101" mass="11730" checksum="7E438D3BC01683F4" modified="2001-03-01" version="1">MTGRRTVMVDTQLRHRERTRQESRARGTMAIWRWARWAALFLAVGWALNSVVKLVEGAQGRELWWPLLSTVIWAAVTVHGFATYRRIRTRTLPALTRRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC46</accession>
    <name>Q9FC46_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7037</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631099.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031394.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7037"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="CAZy" id="GH87">
        <property type="family name" value="Glycoside Hydrolase Family 87"/>
    </dbReference>
    <dbReference type="GeneID" id="1102475"/>
    <dbReference type="KEGG" id="sco:SCO7037"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7141"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008465_0_0_11"/>
    <dbReference type="OMA" id="PWRANGI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd14490">
        <property type="entry name" value="CBM6-CBM35-CBM36_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033801">
        <property type="entry name" value="CBM6-CBM35-CBM36-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176702" evidence="1">
        <location>
            <begin position="36"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="186"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1131" mass="118466" checksum="4987586BDCE5D661" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC72</accession>
    <name>Q9FC72_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldedh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7114</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631175.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031441.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7114"/>
    <dbReference type="GeneID" id="1102552"/>
    <dbReference type="KEGG" id="sco:SCO7114"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7214"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046407_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC72"/>
    <dbReference type="OMA" id="CVWVAPW"/>
    <dbReference type="PhylomeDB" id="Q9FC72"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="170"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC04220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="463" mass="48816" checksum="EB33E5A1E680BE3B" modified="2001-03-01" version="1">MAPADVAEPVYLDALGPRGPYRTRVPDTVTDVSGAEVARLSLVPPVYVDRALAALRKAGPVPADGLDALLAAAAEEFATGTVGGLGVREYEYLVSRTSGTPLTVVRDATRGTARFVARARASAEQGRPRGTVRERPDPSLGAGHAVWARRGEVFAVNASGNHPGVHRLWLEALALGYRVAVRPSRREPFTPHRLVGALHRAGVGQDRLALLPTDHRTARTLIRGADRAVVYGGDDVVAEYAHDARVLPQGPGRTKILVTADTDWREHLDTIVASVADEAGTACVNATAVLVEGDPAPLAEALAARLSRLPGLPPQDTRAVLPVCPLDRALAVDSYLRSVAAGTRAWLGGDGVVDDLGDGSAVLRPAVHQVADAGAPQLGTELPFPCVWVAPWSRSDGIAPLRGTLVLSVLSRDRALLDTLVAEPSIANVYAGDHPTYWMAPGVPHDGYLSDFLMRGKAVVGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH2</accession>
    <name>Q9FCH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MarR-family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4197</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628372.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974774.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4197"/>
    <dbReference type="GeneID" id="1099637"/>
    <dbReference type="KEGG" id="sco:SCO4197"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4261"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_2_11"/>
    <dbReference type="InParanoid" id="Q9FCH2"/>
    <dbReference type="OMA" id="ARLMLKY"/>
    <dbReference type="PhylomeDB" id="Q9FCH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16835" checksum="F84F9CD995F5953E" modified="2001-03-01" version="1">MSSVSSSGRSADDPALDQIGPALSRLRRRTPASSKDLSRNLVLNVIADAPGETTVGGLAVEMGVAQPVASRTVAACIEDGLLRRVASQCDGRRSVLELTEYGEAERRRFAAEQREAFQEITAAWTPQERIQFARLLVRYGADAATWSRSRTASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCJ5</accession>
    <name>Q9FCJ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629341.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030109.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5193"/>
    <dbReference type="GeneID" id="1100634"/>
    <dbReference type="KEGG" id="sco:SCO5193"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5276"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042635_0_0_11"/>
    <dbReference type="OMA" id="SGTPHLY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="167"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="442" mass="46338" checksum="DD8E081CD28EDD2E" modified="2001-03-01" version="1">MDNFRRLSAQPGMLALAGGFAADGGPAHGHRETYGGPGMHPMVKPALRRGWRDLNTVQFGMTPAHALTLAPVDTATGSFLELLNGTRGPALLREAGHRMDLPDGHVDRVVERLALAGLLDDSRGGGPAADALRAKKEVLDRLRPDLASLSLTTSEPGDAIRHLAARRALRVGVRGAGRVGAVLAGLLSGAGVGEIDVRDGGRVEPWDVAPGGLPAEAVGDRRDETARRLVRRAAPGRPPRRGPTTPPEESAPGLSLVIVAPRDDVAVYTPDPTAAESLMASGTPHLYAGVVEGTGVVGPLVLPGETGCAGCLHAERTGRDPAFPRLVAQWRSGRRHRVPPCDLALATTVAGFAAAQALAFLDGRTPSGTGARWEVSLPGLRWQVRPVRPHPSCPCGAARKGKQEHIPEDGGWRATMAGQGPSAEVRHEAERARPAGTWRAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCK3</accession>
    <name>Q9FCK3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5185</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629333.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5185"/>
    <dbReference type="GeneID" id="1100626"/>
    <dbReference type="KEGG" id="sco:SCO5185"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5269"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_11"/>
    <dbReference type="InParanoid" id="Q9FCK3"/>
    <dbReference type="OMA" id="GHHDVQP"/>
    <dbReference type="PhylomeDB" id="Q9FCK3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="204"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="470" mass="51014" checksum="8B3DE2873FA3483F" modified="2001-03-01" version="1">MSHPVDNAVSAVRTYIEQHRAAFLDDLVEWLRIPSVSAQPDHATDVRRSADWLAAKLKETGFPTAEVWPTRGAPAVFAEWPSGDPQAPTVLVYGHHDVQPAAREDGWTSEPFDPVVRENRLYARGAADDKGQVFFHTLGVRAHLAATGRKAPAVNLKLLIEGEEESGSPHFRALVEERAERLTADAVVVSDTGMWSEDTPTVCTGMRGLAECEIRLHGPDQDIHSGSFGGAVPNPATAVARLVAALHDEHARVAIPGFYDGVADLTDRERELFAELPFDERQWLRTAKSYAAHGEAGHTTLERIWARPTAEVNGIGGGYQGPGSKTIIPSSAMVKLSFRLVAGQDPDHVEKAVRTWADEQVPAGIRCEVVFGSATRPCLTPLDHPALRSVVRAMGRAFDKPVRFTREGGSGPAADLQEVLGAPVLFLGISVPSDGWHAPDEKVELDLLLKGVETAAHLWGDLGEHWRHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4B9</accession>
    <name>Q9K4B9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5392</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629531.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973604.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5392"/>
    <dbReference type="GeneID" id="1100832"/>
    <dbReference type="KEGG" id="sco:SCO5392"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5473"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051674_0_0_11"/>
    <dbReference type="OMA" id="GAITIMI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB94563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="289" mass="30173" checksum="861B8FE105C4B42A" modified="2000-10-01" version="1">MSTPQPPTQQAAPDWHAAPGSPFPTYTSPIPVVRTTLVHALASEWTKIKSVRSTLWTLGVFVLLVLGIGLLTGAVVASSDSDLAGESALSLGFFGLLLGSMCVITLGVLTTASEYGTGMIRTTMTACPSRGRVLAAKGIVFFLVAFVVTLICATLVGLAHVSMLEGNGAENPTGAEWLKGTVGVALYVALLGLLSLAMGSIIRHSAGAITIMIGVLLAPLVIALFMFSESLKDVQQALFEYSIPNQMSIFYANSLSESGPSGWDPLWIVLGVTAAAFAAAFALLEKRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4G0</accession>
    <name>Q9K4G0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4178</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628354.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974792.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4178"/>
    <dbReference type="GeneID" id="1099618"/>
    <dbReference type="KEGG" id="sco:SCO4178"/>
    <dbReference type="eggNOG" id="ENOG5031WV2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210415_3_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="32" mass="3557" checksum="FB2F389ECD547B23" modified="2000-10-01" version="1">MEIFFEALLVLVCVGVLAFAGLTVKKLYQGQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXR1</accession>
    <name>PYRR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="2">UPRTase</shortName>
                <ecNumber evidence="2">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="2" type="primary">pyrR</name>
        <name type="ordered locus">SCO1488</name>
        <name type="ORF">SC9C5.12c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625768.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977338.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXR1"/>
    <dbReference type="SMR" id="Q9KXR1"/>
    <dbReference type="STRING" id="100226.SCO1488"/>
    <dbReference type="GeneID" id="1096914"/>
    <dbReference type="KEGG" id="sco:SCO1488"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1497"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_11"/>
    <dbReference type="InParanoid" id="Q9KXR1"/>
    <dbReference type="OMA" id="PIQPDFC"/>
    <dbReference type="PhylomeDB" id="Q9KXR1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000183063" description="Bifunctional protein PyrR">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="110"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <sequence length="193" mass="21248" checksum="73592AAF81477103" modified="2000-10-01" version="1">MDKQQDQQQEARPVLEGPDIARVLTRIAHEIVERAKGADDVVLLGIPTRGVFLARRLADKLEQITERKMPVGSLDITMYRDDLRMHPPRALARTEIPGDGIDGRLVVLVDDVLFSGRTIRAALDALNDIGRPRAVQLAVLVDRGHRELPIRADYVGKNLPTSLRETVKVQLAEEDGRDTVLLGAKPAAPGAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU6</accession>
    <name>Q9KXU6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4295</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628467.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004929928.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4295"/>
    <dbReference type="GeneID" id="1099735"/>
    <dbReference type="KEGG" id="sco:SCO4295"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4363"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:transcription antitermination factor activity, RNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of DNA-templated transcription, termination"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CSD_1"/>
    </dbReference>
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        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="7387" checksum="726911D4540F8A68" modified="2000-10-01" version="1">MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXW9</accession>
    <name>Q9KXW9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mutT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4272</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4272"/>
    <dbReference type="GeneID" id="1099712"/>
    <dbReference type="KEGG" id="sco:SCO4272"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4339"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885423_0_0_11"/>
    <dbReference type="OMA" id="WEHDFTH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="30"/>
            <end position="171"/>
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        <location>
            <begin position="177"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="35446" checksum="C0BFE8F3725B50D6" modified="2000-10-01" version="1">MILTPLALTPDHDIPGPVLTELTALYASHRAFHALSGDFPDPEDIRPEQVATALADELARPGAEVLLARDAGRLVGVAVTLARHPDPSDPDPWIGLLMVDAGLTRQGHGSRLVSLVEDRFRAAGRTAVRLAVLDGNTDALSFWTALGYRVLDHRRDLGAERPCTVLRRELASDKPRTPRRAARVAVLDPEGAVFLLRYDNVEVGVHWAMPGGGLEADENPREGALREVREETGWTDLEPGPLLCTWEHDFTHLSVGPVRQYEHIYVAQGPRREPTGPHLAAAHAADGILTWRWWSRAELAEAPEPLWPPDLALLLETFGGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY52</accession>
    <name>Q9KY52_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4812</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628969.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029882.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4812"/>
    <dbReference type="GeneID" id="1100253"/>
    <dbReference type="KEGG" id="sco:SCO4812"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4889"/>
    <dbReference type="eggNOG" id="ENOG50331E3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055285_1_0_11"/>
    <dbReference type="OMA" id="MWAFFFA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="28069" checksum="CDA440690DCFE237" modified="2000-10-01" version="1">MPDRSLRLLTLPQQSAQPGGRSTVLLRERPSSPPDTPSDRRNGAGQDGSSDQDNPFAPPPEGTPDSPWQPRHPSGDGDSQGASGSQGEGGRSPWGGRWSDRQPGRSPGGFGERPSGSGGPEGSGGGQGPRWDPTDPAQRRARYALLSGMWALFFALFTWPYVALLLGALALYWGISALRAKPRSAADPDTPAPPAEQTGRPQRTAAISGLVTSSLAILLVAASFGAQLIYSDYYTCREDALTNAAEQSCERHLPEQLRPLLGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY73</accession>
    <name>Q9KY73_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO4791</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628948.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974180.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4791"/>
    <dbReference type="GeneID" id="1100232"/>
    <dbReference type="KEGG" id="sco:SCO4791"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4867"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036172_0_0_11"/>
    <dbReference type="OMA" id="IIGRMER"/>
    <dbReference type="PhylomeDB" id="Q9KY73"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="8">
        <location>
            <begin position="336"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB92654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="430" mass="46319" checksum="443BD80AE166B7F7" modified="2000-10-01" version="1">MPEAAAAPVVEPRPPRKLYRSSDGRWLGGVARGLAGHLGLPVVWVRFAFVGLFMADGLGALLYAAFWFFVPLGVGGVEAQKPPSLVTSETGPDGRRRLVTRKPDKGQIVALLLMVVVALVFVGNVDLGGGAKAYLWPTVLVGAGVALVWRQADNARRARWAEVGRHRRTVTLLRSVGGVLLVTAGVTGIFVLQGSAAHLGSVLQAALAVLVGITLLAGPYLVRMTQDLSEERLMRIRAQERAEVAAHVHDSVLHTLTLIQRNAENAGEVRRLARAQERDLRSWLYKPEGNGKDEDDEPTTLAEAVKRNAAEVEDKHGVPLEVVVVGDCPLDERISAQMQAAREAMVNAAKYGGEGGAVQVYAEVEGRTVFVSVRDRGPGFDFDSIPADRMGVRESIIGRMERNGGTARLRAVPDGGTEVELEMERAEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY78</accession>
    <name>Q9KY78_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629176.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973953.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5024"/>
    <dbReference type="GeneID" id="1100465"/>
    <dbReference type="KEGG" id="sco:SCO5024"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5102"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_3_11"/>
    <dbReference type="InParanoid" id="Q9KY78"/>
    <dbReference type="OMA" id="WMGQVGA"/>
    <dbReference type="PhylomeDB" id="Q9KY78"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="30718" checksum="C465F9D0DA44CCA4" modified="2000-10-01" version="1">MTGLGAVFRPQLAPERLRAVARVADEVGLEELWLWEDCFREGGISTAAAALAWTERVRVGVGLLPVPLRNVAVTAMEAATLHRMFPGRPVLGVGHGVQDWMGQVGARAESPLTLLREHLVALRELLRGGRVTSTGRYVRLDDVALDWPPEQPVEVLAGATGPRSLRLAGEAADGTVLTANTPPDGVRRARRLIDEGRAASGRTEAHRVVVYLLAATGSGAAERLRNELVAEGVGAVPDLGVAGDAQAVADAVRRLAEAGADTVILQPTGDEPDPEGFVRFAAERVRPLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYX6</accession>
    <name>Q9KYX6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3004</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627226.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975808.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3004"/>
    <dbReference type="GeneID" id="1098437"/>
    <dbReference type="KEGG" id="sco:SCO3004"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3063"/>
    <dbReference type="eggNOG" id="ENOG50332RH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114556_1_0_11"/>
    <dbReference type="OMA" id="RPVHWML"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB90915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="89" mass="10075" checksum="D6915D796BAAE3D3" modified="2000-10-01" version="1">MLRHTVGRAYDDLAHLAERGPLRTRGTSPVVRDIGYFEPRPGALEVFARIGAGDRLRAMAFRLERGRDLRWRCTAVEVGGPRRTRADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ37</accession>
    <accession>Q7PC61</accession>
    <name>Q9KZ37_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative hydrolase SCO7095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SC3A4.21c</name>
        <name evidence="3" type="ordered locus">SCO7095</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2003" name="J. Bacteriol." volume="185" first="496" last="503">
            <title>Characterization of a novel intracellular endopeptidase of the alpha/beta hydrolase family from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Nagy I."/>
                <person name="Banerjee T."/>
                <person name="Tamura T."/>
                <person name="Schoofs G."/>
                <person name="Gils A."/>
                <person name="Proost P."/>
                <person name="Tamura N."/>
                <person name="Baumeister W."/>
                <person name="De Mot R."/>
            </authorList>
            <dbReference type="PubMed" id="12511496"/>
            <dbReference type="DOI" id="10.1128/JB.185.2.496-503.2003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BK000978">
        <property type="protein sequence ID" value="DAA00405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631156.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972048.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7095"/>
    <dbReference type="ESTHER" id="strco-SC3A4.21C">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.010"/>
    <dbReference type="GeneID" id="1102533"/>
    <dbReference type="KEGG" id="sco:SCO7095"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7195"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_11"/>
    <dbReference type="OMA" id="CASAEYM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="DAA00405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="34701" checksum="DA238416F1A76C4D" modified="2000-10-01" version="1">MKHTHRPGTLPRTPEDPSAPLSPGTHTITVPHGPARVALRYHVAGSGPVCLAHSGGPGIGWEYLRMPGLEDSLTMVYVEPVGTGDSGRLPDPRDYTVATYAHFLHAVVQHLNVPRFALLGHSHGGFVAQRYALDHPAQVTALVLYDTSPVADEEFWSAAVAAMERFVKDHVQDHPEVADYAATLTTRLGLLDDDGATAVLRTLMPAYLHDYWGREAEFAPARRTLRMYASPSLGEEPPFDVRDELPLLTPPALVLAGRHDFICGPRWAALLHEGLFKAELTVLEEAGHLAHLEQPARFDACVLAFLQAQGVVRGPRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ84</accession>
    <name>Q9KZ84_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3061</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627281.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028743.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3061"/>
    <dbReference type="GeneID" id="1098494"/>
    <dbReference type="KEGG" id="sco:SCO3061"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3121"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KZ84"/>
    <dbReference type="OMA" id="FWSYRTW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="21031" checksum="7D8CA9BB2E116B77" modified="2000-10-01" version="1">MEHGSSGAQTAPATPPAPRAGMRERVDRLVREVVKFGAVGGAGVLVNLLVFNFVRHTTDLQVVRASIVATVVAIVFNYLGFRYFAYRDRDKSGQTREMSLFLLFSAVGLVIENGVLYTATYGFGWDSPLQSNIFKFLGIGIGTLFRFWSYRSWVFRALPAREPAARAETFLEHEHPTALPRPDGAPAGHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZA7</accession>
    <name>SYW2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan--tRNA ligase 2</fullName>
            <ecNumber evidence="1">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptophanyl-tRNA synthetase 2</fullName>
            <shortName evidence="1">TrpRS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpS2</name>
        <name type="synonym">trpS</name>
        <name type="ordered locus">SCO4839</name>
        <name type="ORF">SC5G8.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628994.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974132.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KZA7"/>
    <dbReference type="SMR" id="Q9KZA7"/>
    <dbReference type="STRING" id="100226.SCO4839"/>
    <dbReference type="GeneID" id="1100280"/>
    <dbReference type="KEGG" id="sco:SCO4839"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4915"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZA7"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="PhylomeDB" id="Q9KZA7"/>
    <dbReference type="BRENDA" id="6.1.1.2">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136688" description="Tryptophan--tRNA ligase 2">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <sequence length="339" mass="37593" checksum="C45FC36D081D0197" modified="2000-10-01" version="1">MSMANERPRVLSGIQPTSGSFHLGNYLGAVRQWVDMQDTHDAFYMVVDLHAITVPQDPKELRENTRVAAAQLLAAGLDPDRCTLFVQSHVPEHAQLGWLMNCITGFGEASRMTQFKDKSAKQGNDRTTVGLFTYPMLMVADILLYQADQVPVGEDQRQHLELTRDLADRFNQTYGDAFTVPTAYILKETAKIYDLQDPTAKMSKSAATPKGLINLLDEPKATAKKVKSAVTDTDTVVRFDRETKPGVSNLLTIYSTLTGAEIAELERKYEGKGYGALKTDLADVVVEFVTPFRERTRQYLDDPETLDAILAKGAEKARSVAAETLARAYDEVGFLPAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0S8</accession>
    <name>Q9L0S8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4516</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628680.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029703.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4516"/>
    <dbReference type="GeneID" id="1099956"/>
    <dbReference type="KEGG" id="sco:SCO4516"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4588"/>
    <dbReference type="eggNOG" id="ENOG502ZU64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172312_0_1_11"/>
    <dbReference type="OMA" id="FSDTWKK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB77307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="13763" checksum="CF010606A622D932" modified="2000-10-01" version="1">MHWPAQNSTAIRGTSVMSDRTRADLDIIRDCSDSLFRIHREFKEHGNPAEEYSDELGSKDLRDVFGEFSDTWKKTRKKLMKDIENLAKFTKTAADTYDDVDHKLAEALRDARKKSKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1B0</accession>
    <name>Q9L1B0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1571</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625848.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977253.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1571"/>
    <dbReference type="GeneID" id="1097002"/>
    <dbReference type="KEGG" id="sco:SCO1571"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1583"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054794_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L1B0"/>
    <dbReference type="OMA" id="RITLMWC"/>
    <dbReference type="PhylomeDB" id="Q9L1B0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="21397" checksum="D6920F66029490C4" modified="2000-10-01" version="1">MGKTYERIDGRLRAFIEAQPLFFTATAPLAGDGTVNLSPKGLTGCFAVLDELTVAYLDFAGSNAETIAHLRENGRITLMWCAFQGPPNIVRVHGRGEPVFRDDPRFPELLTHFPDIDPTVHGLRAVIVVSAELVRDTCGYAVPFMAYESDRDLHGKRFAREDDASLDAYFTKKEHIASSIDGLPGLPLPLPPSTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1U6</accession>
    <name>Y2948_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0301 protein SCO2948</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2948</name>
        <name type="ORF">SCE59.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627172.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975862.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L1U6"/>
    <dbReference type="SMR" id="Q9L1U6"/>
    <dbReference type="STRING" id="100226.SCO2948"/>
    <dbReference type="GeneID" id="1098381"/>
    <dbReference type="KEGG" id="sco:SCO2948"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3006"/>
    <dbReference type="eggNOG" id="COG1678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057596_2_0_11"/>
    <dbReference type="InParanoid" id="Q9L1U6"/>
    <dbReference type="OMA" id="IYWGGDF"/>
    <dbReference type="PhylomeDB" id="Q9L1U6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000214349" description="UPF0301 protein SCO2948">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <sequence length="193" mass="20329" checksum="BC41293E31BBC187" modified="2000-10-01" version="1">MSGMTEVSSLTGRLLVATPALADPNFERAVVLLLDHDEEGSLGVVLNRPTPVDVGDILEDWADLAGEPGVVFQGGPVSLDSALGVAVVPGGASGERAPLGWRRVHGAIGLVDLEAPPELLAPAVGALRIFAGYAGWGPGQLEDELTEGAWYVVESEPGDVSSPFPERLWREVLRRQRGDLAMVATYPDDPSLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L289</accession>
    <name>RUVC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber>3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ruvC</name>
        <name type="ordered locus">SCO1520</name>
        <name type="ORF">SCL2.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625799.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L289"/>
    <dbReference type="SMR" id="Q9L289"/>
    <dbReference type="STRING" id="100226.SCO1520"/>
    <dbReference type="GeneID" id="1096946"/>
    <dbReference type="KEGG" id="sco:SCO1520"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1529"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_0_2_11"/>
    <dbReference type="InParanoid" id="Q9L289"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="PhylomeDB" id="Q9L289"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000183135" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="188" mass="19890" checksum="B19A98CF96A64B9B" modified="2000-10-01" version="1">MRVLGVDPGLTRRGIGVVEGVAGRPLTMIGVGVVRTPADADLGHRLVAVEQGIEQWLDEHRPEFVAVERVFSQHNVRTVMGTAQASAVAILCASRRGIPVALHTPSEVKAAVTGSGRADKAQVGAMVTRLLRLAAPPKPADAADALALAICHIWRAPAQNRLQQAVALHTAQGPRRPHKLHPSKGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2A6</accession>
    <name>Q9L2A6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5416</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629555.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1100856"/>
    <dbReference type="KEGG" id="sco:SCO5416"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5497"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="InParanoid" id="Q9L2A6"/>
    <dbReference type="OMA" id="GIDCCLH"/>
    <dbReference type="PhylomeDB" id="Q9L2A6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB70646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="36209" checksum="CF8640A75FE28ED5" modified="2000-10-01" version="1">MLADAAARAAELDRLMRPAPRPGAHKVAVLALDGVYPFELGIPHRVLGSADGRYEVLSASVDGRPVRTDSDLTVTPAHGPEVLAGADTVIVPPYAVTAASATVPDPRALAALARVRPGTRLVSICTGAFLLAAAGLLDGRRATTHWALTDHFRELFPRVELDADVLFVDHGDVLTSAGAASGVDVCLHLVRRDHGSEVANQVARRCVVPPYRDGGQAQYIERPVPPASGTGTGPTRDWALRRLDRPLSLDELAAHAAMSTRTFARRFREETGLSPGRWLTQQRLRRARHLLESSDLPVERVAHEVGFATATSLRRHLAAEAGVAPSAYRRTFRASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2F3</accession>
    <name>Q9L2F3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO2463</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626705.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976341.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2463"/>
    <dbReference type="GeneID" id="1097897"/>
    <dbReference type="KEGG" id="sco:SCO2463"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2504"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="InParanoid" id="Q9L2F3"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="PhylomeDB" id="Q9L2F3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB69751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="577" mass="62798" checksum="AE79B7A8FAB0282D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCU8</accession>
    <name>Q9RCU8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB65644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625163.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027399.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0863"/>
    <dbReference type="GeneID" id="1096286"/>
    <dbReference type="KEGG" id="sco:SCO0863"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.855"/>
    <dbReference type="eggNOG" id="COG3182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031962_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RCU8"/>
    <dbReference type="OMA" id="LAWRWHF"/>
    <dbReference type="PhylomeDB" id="Q9RCU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005625">
        <property type="entry name" value="PepSY-ass_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34219">
        <property type="entry name" value="PTHR34219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03929">
        <property type="entry name" value="PepSY_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="485" mass="51014" checksum="437BE123D530FB2B" modified="2000-05-01" version="1">MSESPPLPDTPVTPPSSAAAEVVPLRSGDVTKPVTATGAGSGTTRASLRPLLLRLHFYAGVVVGPFLLVAAVTGLAYTAAPQIESVLYEHELKVTPRGSAEPLAEQVAAAERAVPDGTLLSVTKGAGPTDSTRVTFGKDGLAEGYTLTAFVDPYDHEVLGTLETFGQWLPARAWLDDLHRNLHLGEFGRNYSELAASWLWVEVLGGLALWAGTPRNRQRLRRLMVPDGGAKGRRRTMSWHGAVGLWASVGLLGLSATGLTWSGHAGASIGEVQDALGGSTPAVSTAFPAVGSGKEDAGGTRDVGIDAAVAAAQDAGLRGVLVVTPPSEAGTAYVVKENTRSWPVRQDSVAVAPATGEVTQTLRFDDFPVLAKLTSWGINAHMGLLFGLVNQIVLALLAIGLIAMILWGYRMWWLRRPTRSEGFALGRAPARGAWRRIPGRVLAPALVLAAVIGYYLPLFGLPLLVFLVVDVTVGVVRRRGTGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCX4</accession>
    <name>Q9RCX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oligosaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0936</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625234.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027456.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0936"/>
    <dbReference type="GeneID" id="1096359"/>
    <dbReference type="KEGG" id="sco:SCO0936"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.931"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RCX4"/>
    <dbReference type="OMA" id="GMEPLAW"/>
    <dbReference type="PhylomeDB" id="Q9RCX4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="22828" checksum="7AEAF3C0AF42FDC8" modified="2000-05-01" version="1">MRSEPILRMTGRGRTMLLTFDDGPHPEYTPKILDTLAKYEVRATFFVCGEMADYNRDLLTRMADEGHVVGNHTWSHPLLTKLTRRRIRSEMERTSEVVEQAYGEAPRWFRAPYGAWNRAAFQLGSELGMEPLAWTVDTLDWTTPGTGTIVDRVEEGAAPGVVVLSHDAGGDRSQSVRALRRYLPELLDSGYHLTVPRRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD63</accession>
    <name>Q9RD63_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0619</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624930.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027251.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0619"/>
    <dbReference type="GeneID" id="1096042"/>
    <dbReference type="KEGG" id="sco:SCO0619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.601"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_0_11"/>
    <dbReference type="InParanoid" id="Q9RD63"/>
    <dbReference type="OMA" id="MYHHIIN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB62748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="23643" checksum="8C715F2C31F935D8" modified="2000-05-01" version="1">MTPLILALLAGAAAGVSLGALGAGGSILTVPALVYLLGFTPAAATTASLVVVIVTSVTALVAHARAGAVRWRAGLLFAAAGVLPAAGAGALSSRVPATVLTLLFAALAALAGLHMLGRRAPRENGAVSGARAAGAGAGLGAVTGFLGVGGGFLAVPALVAVLAVPMSAAVGTSLLVVGANALVALAARAYSSVHLDLTLLLPFLAAAVLGAWDGRRLAAKVSAGTLRRVFGAVLLAVAVAMGVSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ7</accession>
    <name>Q9RDJ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2589</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626827.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028440.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2589"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1098023"/>
    <dbReference type="KEGG" id="sco:SCO2589"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2635"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003394_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDJ7"/>
    <dbReference type="OMA" id="DRWDYSI"/>
    <dbReference type="PhylomeDB" id="Q9RDJ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB66267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="743" mass="84124" checksum="3268127DC0D51956" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIV8</accession>
    <name>Q9RIV8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0948</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625245.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027462.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0948"/>
    <dbReference type="CAZy" id="GH38">
        <property type="family name" value="Glycoside Hydrolase Family 38"/>
    </dbReference>
    <dbReference type="GeneID" id="1096371"/>
    <dbReference type="KEGG" id="sco:SCO0948"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.944"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RIV8"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="PhylomeDB" id="Q9RIV8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="6">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110827" checksum="F8BA9D2FB2820D60" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY6</accession>
    <name>Q9RIY6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0179</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36961">
        <property type="entry name" value="T36961"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624515.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978698.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0179"/>
    <dbReference type="GeneID" id="1095603"/>
    <dbReference type="KEGG" id="sco:SCO0179"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.152"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="InParanoid" id="Q9RIY6"/>
    <dbReference type="OMA" id="CENCEKG"/>
    <dbReference type="PhylomeDB" id="Q9RIY6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB53146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="356" mass="37326" checksum="A58AC78A29DF17F1" modified="2000-05-01" version="1">MKGYVFHGPGRSAWEDIPDPELKEPTDAIVRVDAVTICGTDLHILKGDVPEVRPGTVLGHEAVGEIVEVGTDVRTVRPGDRVLVSCITACGRCRYCREGVYGQCLGGGGWILGHLINGTQAEYVRVPYADLSVHSLPGAVTDEDAVLLADIFPTAYEVGVLNGRVSPGDTVVVVGAGPIGLAAVATARLFAPERIVVVDLATARLEAARKLGAEAVADAREDPEQLVADLTGGLGADVVIEAVGVPETFEMCTRVVRPGGHVANVGVHGRPATLHLEDLWSKNVTVTTGLVDTRSTPTLLRMAASGRLPTGQLVTHTFPLERMEEAYEVFSAAADTGALKVVLGGPKREVVAANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ22</accession>
    <name>Q9RJ22_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1846</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976975.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1846"/>
    <dbReference type="GeneID" id="1097280"/>
    <dbReference type="KEGG" id="sco:SCO1846"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1870"/>
    <dbReference type="eggNOG" id="ENOG5034423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176213_3_0_11"/>
    <dbReference type="OMA" id="YACFALC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7225" checksum="CB744498553F4FEC" modified="2000-05-01" version="1">MSIDWAALGSVFGVSLVVTVALVGLFTLGIVGLSRQERAAARGGSAALAVTGAYACFAACTAAVAYGIYLIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJE1</accession>
    <name>Q9RJE1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0751</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61544.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625054.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027330.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0751"/>
    <dbReference type="GeneID" id="1096174"/>
    <dbReference type="KEGG" id="sco:SCO0751"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.742"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_9_11"/>
    <dbReference type="InParanoid" id="Q9RJE1"/>
    <dbReference type="OMA" id="SGGKQVW"/>
    <dbReference type="PhylomeDB" id="Q9RJE1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="314"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="487"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61544.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="828" mass="87830" checksum="DC92E404BE07FB49" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJE5</accession>
    <name>Q9RJE5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0747</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625050.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027329.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0747"/>
    <dbReference type="GeneID" id="1096170"/>
    <dbReference type="KEGG" id="sco:SCO0747"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.737"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_2_11"/>
    <dbReference type="InParanoid" id="Q9RJE5"/>
    <dbReference type="OMA" id="ADTHVPK"/>
    <dbReference type="PhylomeDB" id="Q9RJE5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="18255" checksum="CCDC2B4E6CCEFA2E" modified="2000-05-01" version="1">MRLLITSDTHLPKRAKELPAPLLAEIPRADVVLHAGDWVDTATLDLLESRSRRLVGVHGNNDGPALRARLPEVAYADLGGLRFGVVHETGAAQGREARCAARFPGLDLLVFGHSHIPWDTTAATGLRLLNPGSPTDRRRQPYRTYLTATVADGRLRDVELHRLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJT7</accession>
    <name>Q9RJT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0373</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624696.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027063.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0373"/>
    <dbReference type="GeneID" id="1095796"/>
    <dbReference type="KEGG" id="sco:SCO0373"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.349"/>
    <dbReference type="eggNOG" id="COG1877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101802_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJT7"/>
    <dbReference type="OMA" id="VWLNPEH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB55735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="22443" checksum="BAF22C6B72F46735" modified="2000-05-01" version="1">MRRTTGATGGPIVSRPLLFLDVDGPLNPYAAKPQRRPAGYITLRVPRDGQTPDGHRSALVRRRPLRVWLHPRHGAELLRLDYELCWATTWMAEANRWIAPVIGLPELPFVDFGDVLLQDRPDGVHWKTAPLVEYANGRPFAWVDDEQGGLDQAYVTAHHRAPGLLHHVNPRIGLRDDDFRTLAEFARACTVPQRDRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJX0</accession>
    <name>Q9RJX0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625490.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027648.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1200"/>
    <dbReference type="GeneID" id="1096623"/>
    <dbReference type="KEGG" id="sco:SCO1200"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1199"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RJX0"/>
    <dbReference type="OMA" id="TGMTKSY"/>
    <dbReference type="PhylomeDB" id="Q9RJX0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="191" mass="21033" checksum="2DECD6B9F0902BF5" modified="2000-05-01" version="1">MTTPDDVLAGVGPRLRQVRKEREVTLAALSEATGISVSTLSRLESGLRRPSLELLLPIARAHQVPLDELVGAPPVGDPRVRARPVVRHGRTHWPLTRQAGGLQAFKVLEPQSREEPDPRTHEGYEWLYVLSGRLRLVLGEHDVVLSAGEAAEFDTRVPHWFGSTGEGPAEFLSLFGPQGERMHVRARPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK11</accession>
    <name>Q9RK11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative iron-siderophore ABC-transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0495</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36413">
        <property type="entry name" value="T36413"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624812.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027158.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0495"/>
    <dbReference type="TCDB" id="3.A.1.14.13">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1095918"/>
    <dbReference type="KEGG" id="sco:SCO0495"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.475"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="InParanoid" id="Q9RK11"/>
    <dbReference type="OMA" id="PIGRTHV"/>
    <dbReference type="PhylomeDB" id="Q9RK11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB53325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="30657" checksum="8F02304F688F80ED" modified="2000-05-01" version="1">MVVQSITGTETEVDGASRLAARGVTVGYGTRSVIDGLDVAIPPGVITTIIGPNGCGKSTLLRTLSRLLRPTGGTVVLDGEDIAALRTRDVAKKLGLLPQAPVAPEGLTVSDLVARGRHPHQSWLRQWSSDDADVVRQALAMTGVSDLADRPVDSLSGGQRQRVWISMTLAQGTDLLLLDEPTTYLDLAHAVDVLDLVDDLHESGRTVVMVLHDLNLAARYSDNLVVMREGAILAQGHPRDVITAGLLHEAFGLRAKVIDDPVGDRPLIVPIGRTHVELDRSAPELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKE2</accession>
    <name>Q9RKE2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627697.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029032.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKE2"/>
    <dbReference type="STRING" id="100226.SCO3496"/>
    <dbReference type="CAZy" id="PL6">
        <property type="family name" value="Polysaccharide Lyase Family 6"/>
    </dbReference>
    <dbReference type="GeneID" id="1098932"/>
    <dbReference type="KEGG" id="sco:SCO3496"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3554"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025672_1_0_11"/>
    <dbReference type="OMA" id="IHHNYFY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14251">
        <property type="entry name" value="PL-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039513">
        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176935" evidence="1">
        <location>
            <begin position="31"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="493" mass="52119" checksum="469E339BDD93E2AB" modified="2000-05-01" version="1">MNRPRLSTYAAITVAAITIAALTTAASALASTGDTSSRTPSGNSTPQANATIVNVSSSTQLTTAMANAVAGQTIVLANGSYSIGKLNAKNGTSSAPITIMAAQQGKAIITGGQLEVLSSSYVTFSGLKWTNSNTLKITSSHHIRLTRNHFRLTESSSLKWIIIQGANSHHNRIDHNLFEEKHQLGNFITIDGSSTQQSQYDLIDYNHFRNIGPRATNEMEAIRVGWSAISKSDGFTTVENNLFENCDGDPEIVSVKSNANTVRYNTFRTSQGSVSLRHGNRSQVHGNFFFGGGKTGTGGVRVYGQDHKIYNNHFEGLTGTGYDAALQLDGGDVDTSGALSSHWRVYRATAVHNTFVNNVSNIEIGANYSLAPVDSLVADNIVVGSSGKLFNELKMPKNMTYAGNIGWPTGSATIGITTGVRTVNPLLAKQGEVYRLGTGSPAVNTASGSYSFLADDMDGQSRSGTADVGADELSTGTVVHKPLNSADVGISAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKF4</accession>
    <name>Q9RKF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3483</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627686.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029022.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3483"/>
    <dbReference type="GeneID" id="1098920"/>
    <dbReference type="KEGG" id="sco:SCO3483"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3542"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RKF4"/>
    <dbReference type="OMA" id="YISWILM"/>
    <dbReference type="PhylomeDB" id="Q9RKF4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="34520" checksum="A37C426606AFDFF1" modified="2000-05-01" version="1">MTDVSVPTRSAARTDRPRGRERKAESRHPGSKKTMAAMLAPSIFLLIALNAYPLFYAVSQSLRDGGIAGPGEFIGLENYTTALQDPAFWEAVRFTLLFTVVSVFVAWVIGTALALVLRRSFPGRSVFRVLLLLPWVVPVVVSTTSWNFLVATPSSPVPTLLRELGFGDVQILANPGSAMAIVIIFKIWGTVPFMMMMMSSALQAVDPSVEEACRLDGASRWQRIRHVILPIMSKPVYIAWVLASIFTINDFPSVFLLTGGGPVGSTSTLVVFAYRLVFQDFRTGYGVAVAFLITTALIAMSIYFFRRINRASANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKP7</accession>
    <name>Q9RKP7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response-regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2281</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50590">
        <property type="entry name" value="T50590"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626529.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028247.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2281"/>
    <dbReference type="GeneID" id="1097714"/>
    <dbReference type="KEGG" id="sco:SCO2281"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2318"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="InParanoid" id="Q9RKP7"/>
    <dbReference type="OMA" id="AYVEQSF"/>
    <dbReference type="PhylomeDB" id="Q9RKP7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="24710" checksum="9C6D7ACDD67B1CFC" modified="2000-05-01" version="1">MERDVRPALRIVIAEDDPLLREGLALLLRAEGLDVVATADTAESVLAAIDEHAPDVAILDVRMPPTHTDEGVRAAVEARRRHPGLAVLVLSAYVEQSFATDLLTGGVGGLGYLLKERVGRVEEFMDALGRVAGGGTAIDPEVVAQLFTRTRQDTRMERLSPREREVLALMAEGLGNSAIAGRLVVTDGAVHKHIRSIFVKLDLSPADQVDRRVAAVLHYLENARAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1X9</accession>
    <name>Q9S1X9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0014</name>
        <name evidence="2" type="ordered locus">SCO7833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">A3</strain>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37077">
        <property type="entry name" value="T37077"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624375.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026777.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0014"/>
    <dbReference type="GeneID" id="1095449"/>
    <dbReference type="GeneID" id="1103271"/>
    <dbReference type="KEGG" id="sco:SCO0014"/>
    <dbReference type="KEGG" id="sco:SCO7833"/>
    <dbReference type="eggNOG" id="ENOG5034A3R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178593_0_0_11"/>
    <dbReference type="OMA" id="WVAGHRT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC03651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="92" mass="10014" checksum="8B790AD9E293AA96" modified="2000-05-01" version="1">MALRFVGIAPRTGGEGSPTVWVEEESADLVLQGEEAGALLQALVGSTEWVAGHRTGIPAYERVIRIPFRMVQILREACDAAERASADHRDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S280</accession>
    <name>Q9S280_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1809</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36773">
        <property type="entry name" value="T36773"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626078.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977013.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1809"/>
    <dbReference type="GeneID" id="1097243"/>
    <dbReference type="KEGG" id="sco:SCO1809"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1830"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_2_1_11"/>
    <dbReference type="InParanoid" id="Q9S280"/>
    <dbReference type="OMA" id="RTRETWK"/>
    <dbReference type="PhylomeDB" id="Q9S280"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035970">
        <property type="term" value="P:peptidyl-threonine dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB50877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="19219" checksum="F5EC42F30294D5C9" modified="2000-05-01" version="1">MSVAEPRRIVLFRHAKADWPQVTDHERPLADRGRMDAAEAGRRLADTGVPIDQALCSTSARTRETWKLAVQEFPHRPKTVYEERIYDASPGELIAVLNETPDDLRNVLVIGHNPGMEALTEILAGSAEDEVRERINRRGFPTAAFAVLTFTGSWKDVEPGRAALVDYWAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S297</accession>
    <name>Q9S297_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1733</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36755">
        <property type="entry name" value="T36755"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626006.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977093.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1733"/>
    <dbReference type="GeneID" id="1097164"/>
    <dbReference type="KEGG" id="sco:SCO1733"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1751"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139687_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S297"/>
    <dbReference type="OMA" id="NPYRPGW"/>
    <dbReference type="PhylomeDB" id="Q9S297"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017189">
        <property type="term" value="P:N-terminal peptidyl-alanine acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="17333" checksum="27A1D3E5F6507834" modified="2000-05-01" version="1">MERERIRPATAADVPAVQAVTDAAYLPYVERIGVVPQPMEADHAADVAAGKVFVTDEPGTGRAGPVGLVVVEAHADHLFLDSVAVHPDAHGRGVGRRLLRFVDAHARALGLPEVRLYTNAMMRENQEIYPRYGYEVVERRVDGPYDRVHYRKRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2D4</accession>
    <name>Q9S2D4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0279</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB54164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36467">
        <property type="entry name" value="T36467"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624608.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026984.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0279"/>
    <dbReference type="CAZy" id="GH29">
        <property type="family name" value="Glycoside Hydrolase Family 29"/>
    </dbReference>
    <dbReference type="GeneID" id="1095703"/>
    <dbReference type="KEGG" id="sco:SCO0279"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.253"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_3_11"/>
    <dbReference type="InParanoid" id="Q9S2D4"/>
    <dbReference type="OMA" id="FMIGAYF"/>
    <dbReference type="PhylomeDB" id="Q9S2D4"/>
    <dbReference type="BRENDA" id="3.2.1.51">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB54164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="423" mass="47002" checksum="15E2EA20D11F419B" modified="2000-05-01" version="1">MTMQPWFNEAKLGIFVHYGIYSVDGVPESWALFDQVVPHEQYMRQLDGFTAAAFDPSAWAGLFARAGAGYAVLTARHHDGVALWETRLSDLSVVGRTPAGRDLVAEYVSAMRDRGLRAGLYYSHSDWNHPDYASVRHPRPPHPELVDSPYVSPAPGAEDPRAWERYLDYRDGQVRELLTRFGPDLLWFDGEWERSAEQWRMSELARLIRDLAPDTVCNSRLLGHGDYATPEQGLPMSAPETDWELCLTVNDSWGYRPQDVNHKSVGQLVRYFAQTIGMGGNLLLNVGPRADGTITPEQAQRLEGLGDWIRRHSAAVHGTVGGLPPGHHYGPSTLSPDRRTLYLVCFDPPSETVCVRGLRNAVCRISVLGTGRELAHRRTGGLHDVPGDLWIEAPAPADLAPHGTVLALELDGELELYTGRGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2D7</accession>
    <name>Q9S2D7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB54161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36464">
        <property type="entry name" value="T36464"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624605.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026981.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0276"/>
    <dbReference type="GeneID" id="1095700"/>
    <dbReference type="KEGG" id="sco:SCO0276"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.250"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_11_0_11"/>
    <dbReference type="InParanoid" id="Q9S2D7"/>
    <dbReference type="OMA" id="YQQCHFT"/>
    <dbReference type="PhylomeDB" id="Q9S2D7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="142"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB54161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="417" mass="45653" checksum="207CB4A3BC57E85D" modified="2000-05-01" version="1">MSTRDQIPDRHLRVGVVGVGQRADMAALVNRSGAARIVSCADPDPRGREDARRLFGADVVVHDRYERMLDDELDAVFVLTPDHLHTEPALCFLAAGVAVFVEKPLTITVADCDALLMAAFRSRTRLYVGHNLRHLPVLRRMRELIDDGAVGRVRAVWCRHFVGHGGDFYFKDWHAQRANTTGLLLQKGAHDLDVVHWLAGGFSRNVVAQGALAVYGDNPRRATQETVPPGQRMPDWFDPEVWPPSALRDLNPVVDVEDISMMLARLDNGVLASYQQCHFTPDYWRNYTVIGDEGRLENFGDGIDGDAARVDVWNRRRSGYRADADLSVPVVASDEETHGGADRALVEEFLRFAAAGGPTETSPVAAREAVAAAVAATTSLRSGSTPVDVPPLDPAIVRHFAEHQPAEGADGSGPQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2G8</accession>
    <name>Q9S2G8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2913</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36136">
        <property type="entry name" value="T36136"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627139.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028660.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2913"/>
    <dbReference type="MEROPS" id="M67.009"/>
    <dbReference type="GeneID" id="1098346"/>
    <dbReference type="KEGG" id="sco:SCO2913"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2971"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2G8"/>
    <dbReference type="OMA" id="GAHYVLV"/>
    <dbReference type="PhylomeDB" id="Q9S2G8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB50994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="15648" checksum="D039FB2709DB29BB" modified="2000-05-01" version="1">MLTITQALYDQIVAHAREDHPDEACGVVAGPAGEGRPERFIPMLNAARSPTFYEFDSQDLLKLYREMDDRDEEPVVIYHSHTATEAHPSRTDVTYANEPGAHYVLVSTADTDGAGEFQFRSFRIVAGEVTEEEVKVVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2L1</accession>
    <name>Q9S2L1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1992</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35737">
        <property type="entry name" value="T35737"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626253.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028083.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1992"/>
    <dbReference type="GeneID" id="1097426"/>
    <dbReference type="KEGG" id="sco:SCO1992"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2019"/>
    <dbReference type="eggNOG" id="COG4270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126433_7_0_11"/>
    <dbReference type="OMA" id="WFRIVTG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB52048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="17482" checksum="0B615719E2EAEBD4" modified="2000-05-01" version="1">MSSGAAGGLYPDSSTDRSAQEIAMSETTASPAPAVPARPRGLRAALRVVQVLLALFFAVASALPKLIAHSSAADTFAEMGWGDTGMYAIGVLELTGAVALLVPVLQSVAATALSALMVGAFVVQLTYFDGANAATPLILMVPLLVVARARRGHNEELRRLLRARVRRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-19" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2X7</accession>
    <name>LSPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="1">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Signal peptidase II</fullName>
            <shortName evidence="1">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lspA</name>
        <name type="ordered locus">SCO2074</name>
        <name type="ORF">SC4A10.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34944">
        <property type="entry name" value="T34944"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626333.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028127.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2X7"/>
    <dbReference type="SMR" id="Q9S2X7"/>
    <dbReference type="STRING" id="100226.SCO2074"/>
    <dbReference type="GeneID" id="1097508"/>
    <dbReference type="KEGG" id="sco:SCO2074"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2106"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_2_2_11"/>
    <dbReference type="InParanoid" id="Q9S2X7"/>
    <dbReference type="OMA" id="PKHFAVF"/>
    <dbReference type="PhylomeDB" id="Q9S2X7"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178822" description="Lipoprotein signal peptidase">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="204" mass="21971" checksum="99751001A19FFD08" modified="2000-05-01" version="1">MAEAERIIGTPDIPDAAGEGQERPDADPEREQQEQEQAPERTRGKRRVAVLFAVALFAYLLDLGSKMLVVAKLEHHEPIEIIGDWLRFAAIRNAGAAFGFGEAFTIIFTVIAAAVIVVIARLARKLHSLPWAIALGLLLGGALGNLTDRIFRAPGVFEGAVVDFIAPKHFAVFNLADSAIVCGGILIVILSFRGLDPDGTVHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X873</accession>
    <name>Q9X873_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3517</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36100">
        <property type="entry name" value="T36100"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627717.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029053.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3517"/>
    <dbReference type="GeneID" id="1098953"/>
    <dbReference type="KEGG" id="sco:SCO3517"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3575"/>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024859_2_0_11"/>
    <dbReference type="OMA" id="IYDEAWR"/>
    <dbReference type="PhylomeDB" id="Q9X873"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="489" mass="52206" checksum="05249D1108A75CF4" modified="1999-11-01" version="1">MPRKTTRAEQRAARAGFTEARRQARLAGNPPKHRAEQTLDPDLRPTYPLAGRPGPASARGGKLDLPAHRMTTATASGAYPFVAEGGLGAEGVFIGRDVHAEAAFCFDPFSLYNSGRVEGFTNPNAVLAGIIGMGKSALAKSIATRSIAHGYRIYIPCDPKGEWTAVSQALGGYSIALGPGLPGRLNPLDAPARPASVSEEDWFTEVRKRRLLLLAGLARTVLKRDLRPMEHTALDLALDLVVADAAARGTVPLLGEIAHVLGSPERLDQALGHQAGHLGSAAQDLAHALRRLVHGDLSGMFDAPSTVSFDPTTPMLSIDLSRLGGSGDDTALVLAMTCASAWMESALSDPDGGRRWVIYDEAWRLMRHVGLLERMQSQWKLSRGLGIANLMVIHRLSDLLSAGDAGSRGRVLAEGLLADCSTRIIYRQEPDQLAAAASLLGLTGVETQAVSALTKGRGLWKVAGRSFITQHILHPAERELFDTDARMAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8H2</accession>
    <name>Y3349_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO3349</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3349</name>
        <name type="ORF">SCE7.16</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">To M.leprae ML2435 and M.tuberculosis Rv0495c.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36298">
        <property type="entry name" value="T36298"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627558.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975485.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8H2"/>
    <dbReference type="STRING" id="100226.SCO3349"/>
    <dbReference type="GeneID" id="1098786"/>
    <dbReference type="KEGG" id="sco:SCO3349"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3411"/>
    <dbReference type="eggNOG" id="ENOG502Z8QX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071594_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8H2"/>
    <dbReference type="OMA" id="WQLPVRR"/>
    <dbReference type="PhylomeDB" id="Q9X8H2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000103698" description="Uncharacterized protein SCO3349">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="271" mass="30241" checksum="C06A660D7DD03DFA" modified="1999-11-01" version="1">MPKTKKAKDEKSAKKDKKHIAGDEKGLDFARAWVEFPDPADDEQVFRCDLTWLTSRWNCIFGSGCQGIQAGRADDGCCSLGAHFSDEDDEKRVAGHVARLTPDIWQHHAEGTRNGWTSEDDEGSRQTRPFQGSCIFQNRPGFAGGAGCSLHILALKEGREPLETKPDVCWQLPVRRTYEWIDRPDDTRVLQVSIGEYDRRGWGPGGHDLHWWCTSATSAHGAGDPVYVSYRPELVELMGKAGYDRLVELCEERLASQLPLLAPHPADPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8P1</accession>
    <name>Q9X8P1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36514">
        <property type="entry name" value="T36514"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029124.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3624"/>
    <dbReference type="GeneID" id="1099060"/>
    <dbReference type="KEGG" id="sco:SCO3624"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3683"/>
    <dbReference type="eggNOG" id="ENOG5032PQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282617_0_0_11"/>
    <dbReference type="OMA" id="CDLWLVP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="23793" checksum="17E0EC33301C501F" modified="1999-11-01" version="1">MRSPLLACDLWLVPLVDVLCHTPDNPFAEELAQYDKVLAEAGLPPVPVYQYMPGLSGEVAPVAGFDYDALHFLRRAHLLQVCGLPVTPVDELGGDYEQLLEMFESTAQQSHLVWHYDHAGAYVPVDFPHPLSSDELLAGGGPLGSSHTLLRELEAVAPALGIDPANPPAPPQPPLAPTELEEPAVPAPHDSSPFARERHVWLGLHAAATRSLAQGSMIVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9W1</accession>
    <name>Q9X9W1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36925">
        <property type="entry name" value="T36925"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028045.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1911"/>
    <dbReference type="GeneID" id="1097345"/>
    <dbReference type="KEGG" id="sco:SCO1911"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1937"/>
    <dbReference type="eggNOG" id="ENOG5032SHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106273_0_1_11"/>
    <dbReference type="OMA" id="RWIKKGV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="165" mass="17002" checksum="AE89D449E4D9E49D" modified="1999-11-01" version="1">MRVPAGVAPFGAGYPGCSEPRGGGNTVTGTMHTRPVRDEQHSVGELVGQATEQLSRLVRQEVALAKMELAEKGKRAGRGGGMLGAAGAIAYVGLFALAGTATAALSLVLPVWAAALIVTAALFVIAGVLAMAGRAQLRRAVPPKPEETLGSVRADVDQIRERAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAE5</accession>
    <name>Q9XAE5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35633">
        <property type="entry name" value="T35633"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629440.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030160.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5296"/>
    <dbReference type="GeneID" id="1100737"/>
    <dbReference type="KEGG" id="sco:SCO5296"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5382"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_0_11"/>
    <dbReference type="InParanoid" id="Q9XAE5"/>
    <dbReference type="OMA" id="YRYFPGG"/>
    <dbReference type="PhylomeDB" id="Q9XAE5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="24192" checksum="885B16E33648B9D5" modified="1999-11-01" version="1">MTPQAPTPAYRRLSVEERRVQLLDAALALFAHRPPEEVSLDDVAEQAGVSRPLVYRYFPGGKQQLYEAALSSAADELRLCFDEPRKGPLLARLSRALDRYLTFVDEHDTGFSALLRGGSVVETSQTSGIVDGVRRAAADHIMRHLDVAEPGPRLRMTVRMWITAVEAASLIWLDEDKQPPFDELRDWLVEQFLAVLTVTARRDPQSAALVETLAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAH4</accession>
    <name>Q9XAH4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6690</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35550">
        <property type="entry name" value="T35550"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630764.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031108.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6690"/>
    <dbReference type="GeneID" id="1102129"/>
    <dbReference type="KEGG" id="sco:SCO6690"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6795"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_0_11"/>
    <dbReference type="InParanoid" id="Q9XAH4"/>
    <dbReference type="OMA" id="GIGFPYS"/>
    <dbReference type="PhylomeDB" id="Q9XAH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="426" mass="45623" checksum="28B6411603D5F027" modified="1999-11-01" version="1">MDTEAPAPPTRRPVRQLLAASVGNAVEWYDWYAYTFLATYIADQVFPKGADNSLVPLLSTFAVFAVGFFMRPVGGLLMGAIADRRGRRAALTVTILLMGGSSLLVGLTPTYAAAGVLAPVVLVLARLLQGLSVGGEFAASTTFLVESAGPGRRGLFSSFQYVSTTAGQLVASGIATLLVDTLSEDRMNGWGWRLPFVFGAVLSLVGFWIRQGAQETRSTEQQRAPRPALFEALRRHPRESLLICGITAGGTIAYYTWTSYLPTYAELNAGVAKSDALLAGTISLAFFGLLQPLGGLLSDRFGRRPLLLFFGVGFALLSVPLLHSLRDSFAVLLLVQCAGMVLLTGFTSISAAVNAEVFPPRVRAAGIGFPYSLTVALFGGTAPYVGTLFKDLGHSGIFPWYVAVLCLLSSLVYLRLPETAHKELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAM8</accession>
    <name>Q9XAM8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3-oxoadipate CoA-transferase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6702</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35020">
        <property type="entry name" value="T35020"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031118.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6702"/>
    <dbReference type="GeneID" id="1102141"/>
    <dbReference type="KEGG" id="sco:SCO6702"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6809"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_11"/>
    <dbReference type="InParanoid" id="Q9XAM8"/>
    <dbReference type="OMA" id="VAMMHTN"/>
    <dbReference type="PhylomeDB" id="Q9XAM8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="22494" checksum="91E4F83C52369191" modified="1999-11-01" version="1">MSWTREQMAARAALELEDGQYVNLGIGLPTLIPNYLPDGVEVTLESENGILGTGRYPTDAEVDPDLINAGKETVTVRPGAAFFDSALSFGMIRGGHIDVAVLGAMQVSASGDLANWAIPGKMITGIGGAMDLVHGARTVIVVMTHTAKDGSPKILKKCALPLTGKACVDRVITDLGVLDVTGDGLVLVETAPGVSVDEVVARTDAELVVAKSAEGLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAR1</accession>
    <name>NUOH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoH</name>
        <name type="ordered locus">SCO4569</name>
        <name type="ORF">SCD16A.14c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34617">
        <property type="entry name" value="T34617"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628731.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029736.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAR1"/>
    <dbReference type="SMR" id="Q9XAR1"/>
    <dbReference type="STRING" id="100226.SCO4569"/>
    <dbReference type="GeneID" id="1100009"/>
    <dbReference type="KEGG" id="sco:SCO4569"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4641"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAR1"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="PhylomeDB" id="Q9XAR1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000240112" description="NADH-quinone oxidoreductase subunit H">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="467" mass="51160" checksum="BC1783BC24F05FB7" modified="1999-11-01" version="1">MSPYLAAEDLSMFGTDPWWLVVIKAVFCFAFLMVTVLFSIVWERKVVAWMQLRIGPNRHGPWGMLQSLADGIKLMLKEDVIVKRADKAVYVLAPIVAAIPAFMAIAVIPFGPAGNEVSIFGHRTAMQLTDLPIAMLFILAVASVGIYGIVLAGWSSGSTYPLLGGLRSCAQMISYEIAMGAAFASVFLYSGSMSTSEIVAQQDDRWYIVLLPVSFILYIVTMVGETNRAPFDMPESEGDLVGGFNTEYSSIKFAMFMLAEYVNMVTVSAVATTLFLGGWRAPWPISTFWEGANHGWWPLLWFVVKVQLLLFFFIWLRGTLPRVRYDQLMKLGWKVLIPVSLVWLMLVATVRALRNENYGFSDIALYIGGGVLVLLLLSFLVDMYRDKGGKAADQPAETGTGTGTGTETAFDPMAGGFPVPPMPGQQVPPVPRRRPRRERELIVSGGPDTHSDGPAGGPTDGKEASDG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4W4</accession>
    <name>Q9Z4W4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36312">
        <property type="entry name" value="T36312"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627434.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975596.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3220"/>
    <dbReference type="GeneID" id="1098654"/>
    <dbReference type="KEGG" id="sco:SCO3220"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3282"/>
    <dbReference type="eggNOG" id="ENOG50322SC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126034_0_0_11"/>
    <dbReference type="OMA" id="WWIDWET"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177064" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="14729" checksum="0632BE8CCAE3E6DC" modified="1999-05-01" version="1">MRGILRATALTAAIGAVALLPTTAASAAPAGPAASGCVTDSETEDFGRGEITVCVEDGEVRVTGHVEDLKPGGPFNGGDSGCVGWWIDWETASGPDSSTSTLACPHFTDKPYVEFDYDPTESEYGPKDVTGVADTHLTMVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y6</accession>
    <name>Q9Z4Y6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative salicylate hydroxylase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3245</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36193">
        <property type="entry name" value="T36193"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627457.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028854.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3245"/>
    <dbReference type="DNASU" id="1098679"/>
    <dbReference type="GeneID" id="1098679"/>
    <dbReference type="KEGG" id="sco:SCO3245"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3309"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_11"/>
    <dbReference type="InParanoid" id="Q9Z4Y6"/>
    <dbReference type="OMA" id="RHVMTYT"/>
    <dbReference type="PhylomeDB" id="Q9Z4Y6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="420" mass="44262" checksum="403CE0EA65C8FF97" modified="1999-05-01" version="1">MPKLRIAVVGGGIGGLAAALALTRKGHEVRVYEQAPELREAGVGMHLGPNGSRLLERWGLGERLRALGVRPAGMEVRDWSHGGTLVRQPMGEEWLAEFGAPYYTIHRADLHTMLAESLPSGTVRAGHRLERFTETGGGVRLEFADGSTAGADVLIGADGAHSVVRRTLAGPDTAVFSGQSAFRGVVARDQVPGLPGDTLLVWAGPDARMLVYPVRGGRFLTFVAVVPDPRWRLESWSAPGDLDELAARFDGWNTDVKSLVAAVRESRRWALYDREPLARWSAGAVTLLGDAAHPMLPHHGQGVSQAVEDAAVLAHCLDAPTGPDPSASVSAAAAASAPAAAAASAPAARRAIAAALDAYEGVRRPHTTRVQLGSRGGGSQRLRPDEDGTESTGTMSSLVEDVSWIQRHDAEAGLPPLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z544</accession>
    <name>Q9Z544_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35911">
        <property type="entry name" value="T35911"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630234.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030672.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6128"/>
    <dbReference type="GeneID" id="1101569"/>
    <dbReference type="KEGG" id="sco:SCO6128"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6232"/>
    <dbReference type="HOGENOM" id="CLU_131550_0_1_11"/>
    <dbReference type="OMA" id="CVELAYT"/>
    <dbReference type="PhylomeDB" id="Q9Z544"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="8243" checksum="42EA33FDC2222E58" modified="1999-05-01" version="1">MSSTALRWFKSSYSGSEGGNCIEVAYEWFKSSYSGDEGGNCVEVAQEPTAVHIRDSKAPQGHVTVGPDAWAAFLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z588</accession>
    <name>Q9Z588_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5491</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB37567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35807">
        <property type="entry name" value="T35807"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629626.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030276.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5491"/>
    <dbReference type="GeneID" id="1100931"/>
    <dbReference type="KEGG" id="sco:SCO5491"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5575"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_4_3_11"/>
    <dbReference type="InParanoid" id="Q9Z588"/>
    <dbReference type="OMA" id="TLVWGGS"/>
    <dbReference type="PhylomeDB" id="Q9Z588"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB37567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="182" mass="19722" checksum="8494A6107A939E49" modified="1999-05-01" version="1">MDAMNICVFLSAADLDEHYTRPAKEFAELLGKGGHTLVWGGSDVGLMKVVADGVQESGGKLLGVSVDFLAAKAREGADEMVIAKDLAERKRLLLEKADAVVIMVGGTGTLDEATEILELKKHGHTDKPVVLLNTAGFYDGLKEQFRRMEDEGFLPRPLTELVFFAEEPVGALAYLEESQGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBP8</accession>
    <name>Q9ZBP8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5581</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35665">
        <property type="entry name" value="T35665"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030317.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5581"/>
    <dbReference type="GeneID" id="1101022"/>
    <dbReference type="KEGG" id="sco:SCO5581"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5672"/>
    <dbReference type="eggNOG" id="ENOG5033SP0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092810_1_0_11"/>
    <dbReference type="OMA" id="LLYRMGW"/>
    <dbReference type="PhylomeDB" id="Q9ZBP8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="23328" checksum="358A5B9F36AAA758" modified="1999-05-01" version="1">MGFTIGIGSSRGMREIRSGARRRGRPSECTVVAEFSGLWGWDVVPGARTAQGACSCGLPDCPAPGAHPLDFAPRVPAGATLDEASEAWSRFPGAAVMLAVGRTFDVIEVAEPAGLRALARLERMGVPLGPVAATPQGRAQFFVAPGAAAELPRLLYRMGWDDPAALDLRGLGPGTYLTAPPSDRGGRGPVRWLRPPALDSATKPPAARLLLGTLAYVAHRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBU8</accession>
    <name>Q9ZBU8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6140</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34653">
        <property type="entry name" value="T34653"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630245.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972782.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6140"/>
    <dbReference type="GeneID" id="1101581"/>
    <dbReference type="KEGG" id="sco:SCO6140"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6244"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9ZBU8"/>
    <dbReference type="OMA" id="VYAYRQG"/>
    <dbReference type="PhylomeDB" id="Q9ZBU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA22374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="219" mass="23595" checksum="9091DEC94BF528CA" modified="1999-05-01" version="1">MSAPIRVVICDDQALIRTGLATIVDAQPDLEVVGECGDGQTGVDLARELRPDVVVMDIRMPVLDGLEATRLLAGAGVAHPVKVLVVTTFNLDEYVYEALRAGASGFLLKDAPPDRLLHGIRTVAMGAALLDPDVTRRLVGRYAARIRPAEGTARDIPLTPRETEVLRLIADGLSNSEIAAALVISPETVKTFVSRILTKLDLRDRVQAVVFAYRHGLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBX0</accession>
    <name>Q9ZBX0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prephenate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO3962</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36068">
        <property type="entry name" value="T36068"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628146.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974981.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3962"/>
    <dbReference type="GeneID" id="1099398"/>
    <dbReference type="KEGG" id="sco:SCO3962"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4034"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBX0"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="PhylomeDB" id="Q9ZBX0"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAA22234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="310" mass="33441" checksum="60D061D53960EBD4" modified="1999-05-01" version="1">MPASYAYLGPEGTFTEVALRTLPETATRELVPYVSVQSALDAVRTGEAEAAFVPIENSVEGGITTTLDELVAGQPLMIYREVLLSITFALLVRPGTKLSDIKTVTAHPAAQPQVRNWIKAHLPDVAWESAASNADGARLVQEGRYDAAFAGEFAAERYGLEVLEADIHDAENAQTRFVLVGRPARPAAPTGADKTSVVLWQRDDHPGGLRDLLGEFATRGINLMLLQSRPTGAGIGNYCFCIDAEGHISDRRVADALMGLKRTCLQVRYLGSYPRAEVTPADVDALRPGTSDEAFVAAADWVARCQDGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O69827</accession>
    <name>O69827_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6433</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28703">
        <property type="entry name" value="T28703"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630519.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030914.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6433"/>
    <dbReference type="GeneID" id="1101872"/>
    <dbReference type="KEGG" id="sco:SCO6433"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6533"/>
    <dbReference type="eggNOG" id="COG3450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147448_1_1_11"/>
    <dbReference type="InParanoid" id="O69827"/>
    <dbReference type="OMA" id="HATYTDY"/>
    <dbReference type="PhylomeDB" id="O69827"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="15026" checksum="08103AD26FE98C57" modified="1998-08-01" version="1">MTSRTIKDIVVLGESEPENVRQVRKGPDRWISGELAITNTLHFTSPDGAFTSGIWESTPGKFRAVYEEDEFYHMLHGRVVIADDDGNARTFVPGDTIVVPAGFTGTWEVLEPTKKFYAHYRPLDDDRTGPAVQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O69916</accession>
    <name>O69916_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane lysyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6384</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34878">
        <property type="entry name" value="T34878"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630475.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030881.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6384"/>
    <dbReference type="TCDB" id="9.B.111.1.2">
        <property type="family name" value="the 6 tms lysyl trna synthetase (lyss) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101825"/>
    <dbReference type="KEGG" id="sco:SCO6384"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6492"/>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_7_3_11"/>
    <dbReference type="InParanoid" id="O69916"/>
    <dbReference type="OMA" id="VMLECTD"/>
    <dbReference type="PhylomeDB" id="O69916"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="9">
        <location>
            <begin position="31"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="250"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA19595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="589" mass="66400" checksum="03593CE1879E0B44" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O86659</accession>
    <name>O86659_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6367</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34978">
        <property type="entry name" value="T34978"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630458.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030864.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6367"/>
    <dbReference type="GeneID" id="1101808"/>
    <dbReference type="KEGG" id="sco:SCO6367"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6479"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="O86659"/>
    <dbReference type="OMA" id="WENIEAE"/>
    <dbReference type="PhylomeDB" id="O86659"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044874">
        <property type="term" value="P:lipoprotein localization to outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089705">
        <property type="term" value="P:protein localization to outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="245" mass="25885" checksum="B530A8B0E9E58095" modified="1998-11-01" version="1">MSAMPSGPSDDVALAARELYRFYRAGEEETLALRGVSLRVRRGETVAVVGPSGAGKSTLLACLAGLDEPSGGEVRVAGVRISHRPETERARLRARHVGVLLQSRNLLPHLTVRDNVQLAQHAVRGRPAVRAGALLEQVGLGRRAGALPRQLSGGELARAGLAVALANSPAVLLADEPTGELDGMTEELVLRMLRDRAADGCAVLIVTHSAEAVRGADRVITLDDGRAHEGREGAAQAKESHHVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O86687</accession>
    <name>O86687_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6641</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35050">
        <property type="entry name" value="T35050"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630717.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031067.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6641"/>
    <dbReference type="GeneID" id="1102080"/>
    <dbReference type="KEGG" id="sco:SCO6641"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6746"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681359_0_0_11"/>
    <dbReference type="InParanoid" id="O86687"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021754">
        <property type="entry name" value="DUF3320"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11784">
        <property type="entry name" value="DUF3320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="44410" checksum="890E9C763CCD503A" modified="1998-11-01" version="1">MVTVARLNVAVTRARHRVEVVASFHGADLPDNANKSVQHLKRYLQYAEQGPTVLAPAAPDAEAAPESPFEEDVLAVLRDWGYDVQPQGGVAGFRIDMAVRHPGAPGAYALGIECDGAMYHSSRAARDRDRLREEILRGLGWNLHRIWGTDWYRNRKDAQRRLREAVEEACAADPYAPEPVSTPVPSTEQTPAEIAIVPVAESDRSEWSRPYRALGWEKPYELKDTLSTAAGLPGVDLHDPAAKAVVAEVAHHIITMEGPIEEDVLIGRVRSAWLLDRSGQIVQSSVRDALSRLRKKNKAVRSGTVWDLPAREVTFARTPTPDFDRKKVSQVPSAERRIALFGILSESPGMRREELARETARFFGWLRLGPDIKAAFDQDIEELIGGGLVTSGSSGLLPVEGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O87839</accession>
    <name>O87839_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TPP-requiring enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6584</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35772">
        <property type="entry name" value="T35772"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630663.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972394.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6584"/>
    <dbReference type="GeneID" id="1102023"/>
    <dbReference type="KEGG" id="sco:SCO6584"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6689"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_3_11"/>
    <dbReference type="InParanoid" id="O87839"/>
    <dbReference type="OMA" id="PGPYGCL"/>
    <dbReference type="PhylomeDB" id="O87839"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="200"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="394"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02776"/>
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    </evidence>
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        <source>
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        <source>
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    <sequence length="560" mass="60104" checksum="A51A371A3E77AA0E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="152" xmlns="http://uniprot.org/uniprot">
    <accession>P16544</accession>
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        <recommendedName>
            <fullName>Putative ketoacyl reductase</fullName>
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        <name type="primary">actIII</name>
        <name type="ordered locus">SCO5086</name>
        <name type="ORF">SCBAC28G1.12c</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
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    <reference key="1">
        <citation type="journal article" date="1988" name="Gene" volume="74" first="305" last="320">
            <title>Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Hallam S."/>
                <person name="Malpartida F."/>
                <person name="Hopwood D."/>
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            <dbReference type="PubMed" id="2469622"/>
            <dbReference type="DOI" id="10.1016/0378-1119(88)90165-5"/>
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        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
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    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
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    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Biochemistry" volume="43" first="14529" last="14538">
            <title>Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.</title>
            <authorList>
                <person name="Korman T.P."/>
                <person name="Hill J.A."/>
                <person name="Vu T.N."/>
                <person name="Tsai S.C."/>
            </authorList>
            <dbReference type="PubMed" id="15544323"/>
            <dbReference type="DOI" id="10.1021/bi048133a"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH NADPH</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Structure" volume="12" first="1865" last="1875">
            <title>The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.</title>
            <authorList>
                <person name="Hadfield A.T."/>
                <person name="Limpkin C."/>
                <person name="Teartasin W."/>
                <person name="Simpson T.J."/>
                <person name="Crosby J."/>
                <person name="Crump M.P."/>
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            <dbReference type="DOI" id="10.1016/j.str.2004.08.002"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH NADPH</scope>
        <scope>SUBUNIT</scope>
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    <comment type="pathway">
        <text>Antibiotic biosynthesis; actinorhodin biosynthesis.</text>
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    <comment type="subunit">
        <text evidence="3 4">Homotetramer.</text>
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    <comment type="similarity">
        <text evidence="5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        </location>
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    <feature type="active site" description="Proton acceptor" evidence="2">
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    <feature type="binding site" evidence="3 4">
        <location>
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        <ligand>
            <name>NADP(+)</name>
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        <location>
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        <ligand>
            <name>NADP(+)</name>
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    <feature type="binding site" evidence="1">
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        <ligand>
            <name>substrate</name>
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            <name>NADP(+)</name>
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</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q05954</accession>
    <accession>Q9KZU3</accession>
    <name>Y4158_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized HTH-type transcriptional regulator SCO4158</fullName>
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    </protein>
    <gene>
        <name type="ordered locus">SCO4158</name>
        <name type="ORF">SCD84.25c</name>
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    <organism>
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            <taxon>Streptomycetaceae</taxon>
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    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Gene" volume="130" first="145" last="150">
            <title>The Streptomyces coelicolor glnR gene encodes a protein similar to other bacterial response regulators.</title>
            <authorList>
                <person name="Wray L.V. Jr."/>
                <person name="Fisher S.H."/>
            </authorList>
            <dbReference type="PubMed" id="7688332"/>
            <dbReference type="DOI" id="10.1016/0378-1119(93)90359-B"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L03213">
        <property type="protein sequence ID" value="AAA02839.1"/>
        <property type="molecule type" value="Unassigned_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="PN0644">
        <property type="entry name" value="PN0644"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628335.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974813.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q05954"/>
    <dbReference type="SMR" id="Q05954"/>
    <dbReference type="STRING" id="100226.SCO4158"/>
    <dbReference type="GeneID" id="1099598"/>
    <dbReference type="KEGG" id="sco:SCO4158"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4222"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_11"/>
    <dbReference type="InParanoid" id="Q05954"/>
    <dbReference type="OMA" id="YNRYDAY"/>
    <dbReference type="PhylomeDB" id="Q05954"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000108010" description="Uncharacterized HTH-type transcriptional regulator SCO4158">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00111"/>
        </source>
    </evidence>
    <sequence length="340" mass="36767" checksum="35F32456E94E1A15" modified="2001-10-18" version="2">MAKVTRDDVARLAGTSTAVVSYVINNGPRPVAPATRERVLAAIKELGYRPDRVAQAMASRRTDLIGLIVPDARQPFFAEMAHAVEWAASERGKMVLVGNSDYVGEREVHYLRAFLGMRVSGLILVSHALNDNAAAEIDAWDARVVLLHERPEAIDDVAVVTDDLGGAQLAVRHLLEHGYAYVACMGGTAETPSVGDPVSDHVEGWRRAMKEAGLSTEGRLFEAPYNRYDAYRVGLELLSGPQRPPAIFCSTDDQAIGLLRAARELRIDVPGELAVAGFDDIKEADLADPPLTTVASDRSAMARSAVDLVLDDGLRVAGSRRERLKVFPSQLVVRQSCGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKF3</accession>
    <name>Q7AKF3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO5999</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC37548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKF3"/>
    <dbReference type="STRING" id="100226.SCO5999"/>
    <dbReference type="GeneID" id="1101441"/>
    <dbReference type="KEGG" id="sco:SCO5999"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6099"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_11"/>
    <dbReference type="InParanoid" id="Q7AKF3"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="PhylomeDB" id="Q7AKF3"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030350">
        <property type="term" value="F:iron-responsive element binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="64"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="702"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC37548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="904" mass="97380" checksum="CFE76ABC492E822D" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q7APH9</accession>
    <name>Q7APH9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mmyJ</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639848.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039540.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095321"/>
    <dbReference type="KEGG" id="sco:SCP1.238"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8185"/>
    <dbReference type="HOGENOM" id="CLU_097806_4_2_11"/>
    <dbReference type="InParanoid" id="Q7APH9"/>
    <dbReference type="OMA" id="RYRRCEL"/>
    <dbReference type="PhylomeDB" id="Q7APH9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF46785"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="12136" checksum="F18CDA854AE84DDD" modified="2004-07-05" version="1">MAARITTERITDHPDADAITLQGVLDALVDPVRRSIVRQLAKAPEDIACGTFDITVSRSTGTHHFKVLRQAGIIRQYYIGTSKMNTLRTDDLDQAFPGLLTAIVDAAARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK9</accession>
    <name>Q8CJK9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7139</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733724.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031455.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7139"/>
    <dbReference type="GeneID" id="1102577"/>
    <dbReference type="KEGG" id="sco:SCO7139"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7241"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJK9"/>
    <dbReference type="OMA" id="WNGPMRM"/>
    <dbReference type="PhylomeDB" id="Q8CJK9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="38"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD55525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="488" mass="51477" checksum="BE3AB22B2CD7C492" modified="2003-03-01" version="1">MSRAARCSLGDMNESPRTPFPTPSHWIDGRAVTGSGPLIDVVNPADESVIAHLHEATADDVDMAVDAAVAAIPGWAATPPRHRADVMRRLAEGLQKRSEELAATITLEMGAPIAFSRQAQVGFPVASTLAAIAAAERFEWSERIENSLVVREPVGVVGAITPWNFPLQQLVTKVVPAMLAGNTVVLKPSELSPLSARMFAEIATEAGLPNGVFNVVQGTGPVVGEALSRHPKIDMISFTGSTRAGKSVSSAASVTVKRVALELGGKAAHIVLPEADLDSAVARGLAFAWANAGQACGAYVRMLVPEDLQTAVVDRLRTAAQEYVVGDPADEATRIGPLASETQRRRVDDYIRRGIADGATLVTGGPGRPEGFETGAYVRPTIFSDVAPESVIAQEEIFGPVLVVIPYTDDEHAVEIANGTVYGLNAAVTGDEDHAMAIAVRLRVGQVDVNGGRHNFQAPFGGYKQSGNGREMGRAGLEEFLETKAITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJN2</accession>
    <name>Q8CJN2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6365</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAD55513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34976">
        <property type="entry name" value="T34976"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030862.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6365"/>
    <dbReference type="GeneID" id="1101806"/>
    <dbReference type="KEGG" id="sco:SCO6365"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6477"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325928_0_0_11"/>
    <dbReference type="OMA" id="RTINDNM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044874">
        <property type="term" value="P:lipoprotein localization to outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="797"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="779"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD55513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="880" mass="90678" checksum="D5106962BA749D1B" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJU2</accession>
    <name>Q8CJU2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pvc16_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4260</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAD55477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733632.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029538.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4260"/>
    <dbReference type="GeneID" id="1099700"/>
    <dbReference type="KEGG" id="sco:SCO4260"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4327"/>
    <dbReference type="eggNOG" id="ENOG502ZDRH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082097_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJU2"/>
    <dbReference type="OMA" id="EYDAGPP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="24679" checksum="7E6BA6504598C025" modified="2003-03-01" version="1">MIHEVDEVLKALLKGGALTDSGIDVAFEAPTRDWAARRNAPVVNAYLYDIREDVGRRHRGQVAVRDQDDIVVKRRQPPRWFRLSYLVTAWTKTPQDEHRLLSAVLATLLPREQLPPYELPGALGAMNLPVPMTVAGVQTESRSLAEIWSALGGELKPSLDLVVTAPFPAYPEYDAGPPVTEGATVRIGGVEGDPPMSEGRSHRPHQVAAARAARKAVTDGRTKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK03</accession>
    <name>Q8CK03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCO2206 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028196.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2206"/>
    <dbReference type="GeneID" id="1097639"/>
    <dbReference type="KEGG" id="sco:SCO2206"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2244"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_0_1_11"/>
    <dbReference type="InParanoid" id="Q8CK03"/>
    <dbReference type="OMA" id="MQRPIVT"/>
    <dbReference type="PhylomeDB" id="Q8CK03"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14984" checksum="CD9E5E6234B7B5CD" modified="2003-03-01" version="1">MVNEFRHPPATVSGMEIWINPACSKCRSAISLLDAEGADYTVRRYLEDVPSADEIREVLTRLGLEPWDITRTQEAAAKELGLRDWPRDEASRDRWITALTEHPKLIQRPIITADDGTAVVGRTDEAVRDALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IY7</accession>
    <name>Q93IY7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629248.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030056.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5098"/>
    <dbReference type="GeneID" id="1100539"/>
    <dbReference type="KEGG" id="sco:SCO5098"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5178"/>
    <dbReference type="eggNOG" id="ENOG50338IC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149376_1_0_11"/>
    <dbReference type="InParanoid" id="Q93IY7"/>
    <dbReference type="OMA" id="RILMFIW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021214">
        <property type="entry name" value="DUF2568"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10823">
        <property type="entry name" value="DUF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="154" mass="16265" checksum="13152A0B14428947" modified="2001-12-01" version="1">MPDCTRPCPIVPVPMPMPMPMPMPMPMPVPVPASVPNQESAVLSSLKAVNLLVMFLLELAVYTAVVLWGVAVGGTWPVEVALGVGAPVVMMAAWALFGSPRARRPARGAGRFVLEVLWFGAGAAALAASGRPWWAAALAGVCLVNAVLRRLWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J11</accession>
    <name>Q93J11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3997</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628179.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029368.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3997"/>
    <dbReference type="GeneID" id="1099433"/>
    <dbReference type="KEGG" id="sco:SCO3997"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_11"/>
    <dbReference type="InParanoid" id="Q93J11"/>
    <dbReference type="OMA" id="PQTEPHI"/>
    <dbReference type="PhylomeDB" id="Q93J11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="173"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC44721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="41800" checksum="4FBF163FA4A3CE90" modified="2001-12-01" version="1" fragment="single">MAGKRKSRRGFGRVRKLPSGRFQARYPGPDGVLRPADRTFATTTDADRWLMRKRIEIEEGCWLDPAEGQTTVRDWAARWLAAVSPQLKHKTQASYRSLINSLINPVLGDRELSSLRPITVTEWVGAMRTKGLSASRIRQAYRVLSQIMRSAVDNDMIPQTPCRGVRLPRMPQTEPHILTPLEASRIVKGATKPHDLLIALLAYAGLRVGEAFALRRVDVDVSGGFVLVDENLAEANGVLVFDTPKSHQKRLLRVGPSLAKRLGRHLETLPGGDDALLFTTPGGKPLRYNQWRKAYFDPAVSAAGLTDVTPHDLRASHGTWVADRYGVMTAAHRLGHSNASVTTRHYARPVAGRDDQVAEAADSWLSGSEDNDDGSAAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J32</accession>
    <name>Q93J32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3975</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628158.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974968.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3975"/>
    <dbReference type="GeneID" id="1099411"/>
    <dbReference type="KEGG" id="sco:SCO3975"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4048"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_3_1_11"/>
    <dbReference type="OMA" id="ACKHGRP"/>
    <dbReference type="PhylomeDB" id="Q93J32"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="50"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="22025" checksum="C69823C4B32A44A7" modified="2001-12-01" version="1">MRHRAGFGRFPAQGDGASTPWRGAKEVSGVALVVAQEVPTSSSMAVPHGPAGVGEARHRMRDQLRRGGVAESVIDDAVLVLSELLSNACKHGRPLGDALAGDGDVRAAWQVDAGGRLLVEVTDGGGPTRPAPATPSVTAHGGRGLNIITALADDWGVRDDARGEVTVWVVVHDDVHDPDAGHRRDDFAARISAPAVSEIPGLDFADAFDDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J36</accession>
    <name>Q93J36_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3971</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628154.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029348.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3971"/>
    <dbReference type="GeneID" id="1099407"/>
    <dbReference type="KEGG" id="sco:SCO3971"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4044"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_581258_0_0_11"/>
    <dbReference type="InParanoid" id="Q93J36"/>
    <dbReference type="OMA" id="GMLACWE"/>
    <dbReference type="PhylomeDB" id="Q93J36"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="477" mass="49840" checksum="AB50AA568E1EF877" modified="2001-12-01" version="1">MNAPHPAKVAGIDSTVPAPAHTVAPAAAGTSPAAESRTADAAAVTDASGTPCAPGALLQDRLAGWVSDLTTLHELTERLVHTGTLAEGLQEVLRAGAALVGARRGLVVLEPADGLGPDTTVGLGLARADLGHIETVPRSALPHGRILDGPPVDEDGIAEPDLLAEKALDPRHREVAARLGYAASYALPLSAEGTPRLGAAVWLYDEPAEPGERQRHLAGLYVRYAAPHLARLLEVERTRTSMATMAEELLPSRLPRVPGVQLAARHRTGPLGGGDWYDALPLPDAALGLSVGSVTGSGPSAVAAMGRLRASLRAYAVMEGEDPVAVLSDLELLLRLTEPARSATALFGYCEPALRRITLAGAGHSPPLLIGERRTEFVETSLSAPLGMLACWEAPSVELQAEPGETVLLYTDGLLHRTGDRADRAFARLHAAAAGVPRAARQDPDAVVEHVLRTVLPDGKAEADSEEDVVLLAVRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JI7</accession>
    <name>Q93JI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1975</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626237.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976844.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1975"/>
    <dbReference type="GeneID" id="1097409"/>
    <dbReference type="KEGG" id="sco:SCO1975"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2001"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114078_0_0_11"/>
    <dbReference type="OMA" id="HWFPFDL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="23318" checksum="002BD6B68123E379" modified="2001-12-01" version="1">MRLEAITWDRLGDRLAERLLDLEPTDGSAWTRVALDGAPAARPGDLAERVGEALRVRGRPSLVVGTEGFLRPASLRLEYGHHDAESYYNGWYDTAALWREVFDPLGPGGNGRVLPDLWDPVTDRATRSPYAQLPSGGALLLHGPFLLRHWFPLDLSVHLVLTPGALRRRTPGTEQWTLPAFERYDQETDPAGTADVLVRADDPRHPAWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ8</accession>
    <name>Q93JJ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase ECF sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4996</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629148.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973981.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4996"/>
    <dbReference type="GeneID" id="1100437"/>
    <dbReference type="KEGG" id="sco:SCO4996"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5077"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_4_11"/>
    <dbReference type="InParanoid" id="Q93JJ8"/>
    <dbReference type="OMA" id="VRWGRVS"/>
    <dbReference type="PhylomeDB" id="Q93JJ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="23"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC40609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="18703" checksum="A61B1442F33790C5" modified="2001-12-01" version="1">MRQGRADEYAEFAVARAGHLYRSACLLTAGDTHLAEDLVQETFGRLYVRWGRVSRAENPAAYAQTVLTRAFLAHQRRRSSGERATDVFPDLPGAGDGDASLRLTLLDALARLPAKDRAVVVLRYWDDRSVEQTADVLGVSSAAVRTRCSRALGRLRELLGEDLSEYARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADK7</accession>
    <name>Q9ADK7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4953</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629105.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029973.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4953"/>
    <dbReference type="GeneID" id="1100394"/>
    <dbReference type="KEGG" id="sco:SCO4953"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5033"/>
    <dbReference type="HOGENOM" id="CLU_2865933_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="7067" checksum="E76F6144C11B4C20" modified="2001-06-01" version="1">MLDKFPALTELGQLRVSDGRPHETALVLGSFRRRSNGDWDFVVGGKGYSGGLEELLRDFGVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK80</accession>
    <name>Q9AK80_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628219.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007451194.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4037"/>
    <dbReference type="GeneID" id="1099473"/>
    <dbReference type="KEGG" id="sco:SCO4037"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4100"/>
    <dbReference type="eggNOG" id="ENOG502ZDQK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186189_1_1_11"/>
    <dbReference type="OMA" id="FMTWAAN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323091" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="58" mass="6053" checksum="FA6104B353C408AE" modified="2001-06-01" version="1">MAVNSKKIAVYVVVVFVLYVIITDPAKAADYVQIGFQGISDAAGAVGDFMTWAANGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWT3</accession>
    <name>Q9EWT3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0738</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625042.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978123.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0738"/>
    <dbReference type="GeneID" id="1096161"/>
    <dbReference type="KEGG" id="sco:SCO0738"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.728"/>
    <dbReference type="eggNOG" id="ENOG5033NHD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112913_0_0_11"/>
    <dbReference type="OMA" id="REGYYTA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="19895" checksum="593F20C76888CC33" modified="2001-03-01" version="1">MSAFLQQLPALMGVVIGALGSYLAVVRSDRARLRRESEARWEERRLAVYSDYARTVKTSVTLTYRVAAHLGNDPHPHPLTPREAAPAQAEATVARDPAGEALLLLGSKDVVDKARVWVVAVMEMERFLREETRDPDAWRAMLEGQRTAREGYYAAVREDLALPPGHGARWPLPPVSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWY5</accession>
    <name>Q9EWY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1141</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625434.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977690.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1141"/>
    <dbReference type="GeneID" id="1096564"/>
    <dbReference type="KEGG" id="sco:SCO1141"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1138"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EWY5"/>
    <dbReference type="OMA" id="WQHRHGS"/>
    <dbReference type="PhylomeDB" id="Q9EWY5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC13093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="14982" checksum="1473B87CDD0E0F2E" modified="2001-03-01" version="1">MPDAFTTRVLSLATGSAERVADITGDCESFLRDAASGRDGLLNVFVPHATAGIAIIETGAGSDDDLLSALHTLLPADDRWQHRHGSPGHGRDHVLPAFVPPHATLPVIAGRLELGTWQSVCLVDTNRDNPDRRVRLSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Z1</accession>
    <name>Q9F2Z1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4356</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628526.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974625.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4356"/>
    <dbReference type="GeneID" id="1099796"/>
    <dbReference type="KEGG" id="sco:SCO4356"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4424"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014183_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2Z1"/>
    <dbReference type="OMA" id="DTYDGTH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="25192" checksum="DBBA33DA8B338966" modified="2001-03-01" version="1">MLRFMFVGDSMTIGSAGEHTWRYRLWQHLRDSCGRPFTFVGPRETLHDRVTDAPTSCAYAEPGFPRAHLAGWGEGWHHMTPLIAQTVRSCRADVLLVSLGLIDLGFYTNAEQTAANVRAFVANARSANPRVRVAVMPVLHNIRVDADETFAEQVAHFNELLVKTVADLDDADSPLLLVPPPPGYDFHTDTYDGTHPNESGEHRIAEAFATAMAEEWGLGGPYSPGPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F390</accession>
    <name>Q9F390_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative merR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7585</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631628.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971558.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7585"/>
    <dbReference type="GeneID" id="1103023"/>
    <dbReference type="KEGG" id="sco:SCO7585"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7700"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F390"/>
    <dbReference type="OMA" id="IDICLHP"/>
    <dbReference type="PhylomeDB" id="Q9F390"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="14797" checksum="3EBA13311495110E" modified="2001-03-01" version="1">MCAADHSREQVMRIGEVASRAGVSVRSVRYYEDQGLLASTRSAGGQRQYTEHEVERVQFLQRLYAAGLSSRTIAELLPCVDAPSEVHSDAALERMAQERDRLTEHIADLVRTRDALNALMTAAREYRDAQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3E8</accession>
    <name>Q9F3E8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7609</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631650.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031779.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7609"/>
    <dbReference type="ESTHER" id="strco-SCO7609">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1103047"/>
    <dbReference type="KEGG" id="sco:SCO7609"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7726"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046066_3_2_11"/>
    <dbReference type="OMA" id="VCPEFTP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="23839" checksum="C4249A9CBDD1C75B" modified="2001-03-01" version="1">MDIVLIGGLWLNGSVWEGVASTLESLGHRPVPLTLPGQGDGAATATLDDQVAAVLAAVDAAPGRPMVVGHSAACALAWLAADRRPGRLAKVALIGGIPTPDGRPYADFFEVRDGVMPFPGWEPFQGPDAADLDEAARHELAAAAIPVPEAVARGVVRLSDERRYDVPVVVVCPEFTPAQARGWIDAGDVPELARAKHVDFADIDSGHWPMITKPAELARVLAAAAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBT6</accession>
    <name>Q9FBT6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631215.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031467.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7156"/>
    <dbReference type="GeneID" id="1102594"/>
    <dbReference type="KEGG" id="sco:SCO7156"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7257"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_13_0_11"/>
    <dbReference type="InParanoid" id="Q9FBT6"/>
    <dbReference type="OMA" id="ASWFRPR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="19104" checksum="3EB5BDD7AB0CCBE6" modified="2001-03-01" version="1">MTGAQAPRRTSGTARTAALPRSCTKRKKIMFERILVAVDSSRTRLTTVHSAAAMARLTGARVRVLHVAASAATLAAVVPLEDDSEAESVLDEAVGVLRRSGVPAEGVMVHALTTQIAGVISETAAAWKADLLVLTPHRRDMFGALWDPRVSDAVVHTGRTAVLLVPEGDGNDPAEPPVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC31</accession>
    <name>Q9FC31_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631115.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031404.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7053"/>
    <dbReference type="GeneID" id="1102491"/>
    <dbReference type="KEGG" id="sco:SCO7053"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7157"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119884_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FC31"/>
    <dbReference type="OMA" id="FKPYPGK"/>
    <dbReference type="PhylomeDB" id="Q9FC31"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="15252" checksum="31710F565A14851D" modified="2001-03-01" version="1">MRAFRAAVEAHDMDAVEALLADDVVFSSPVVFKPYRGKAVTAAILRAVERVFEDFRYERVIGEADGRDHALLFAARVDDREISGCDFLHLDASGRIAELTVMVRPLSGAQALQAAMAAQFERIAEEAQERQDARAASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC44</accession>
    <name>Q9FC44_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7039</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631101.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031396.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7039"/>
    <dbReference type="GeneID" id="1102477"/>
    <dbReference type="KEGG" id="sco:SCO7039"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7143"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1936883_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9FC44"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="5">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC01537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="13326" checksum="9FACAD9DEB77807F" modified="2001-03-01" version="1">MPVQPTTTLCPPAASADLGRVVEEGGTAEVSGASRHPYAEAPLSATLSLPERPGRIVPHGPVPSATRPPSGCPFRTRCWKADDACATVFSAAAEAQADGYRPARAGACVSGHAPSGRRAALRPADTRMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCA0</accession>
    <name>Q9FCA0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ordered locus">SCO1213</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625502.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977618.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1213"/>
    <dbReference type="GeneID" id="1096636"/>
    <dbReference type="KEGG" id="sco:SCO1213"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1212"/>
    <dbReference type="eggNOG" id="COG3442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064047_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCA0"/>
    <dbReference type="OMA" id="GTYMHGP"/>
    <dbReference type="PhylomeDB" id="Q9FCA0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="242" mass="26218" checksum="C54CC0EB005D9135" modified="2001-03-01" version="1">MSDNQLRIVWIYPDLLSTYGDQGNALVVERRARQRGLDVARLDVRSDQPIPTSGDIYLVGGGEDRPQRLAAERLRRDGGLYRAVENGAIVFSVCAGYQILGHEFINDLGQREPGLGLLDVVSTRGEGARCVGDVLGDIDPRLGLPPLTGFENHQGVTHVGPNARPLAQVRFGNGNGTGDGTEGAYNDTVFGTYMHGPVLARNPLIADLLLKLALDVNALPPTDDRWYEALRNERIAAAQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3G3</accession>
    <name>Q9K3G3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1278</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625565.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977553.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1278"/>
    <dbReference type="GeneID" id="1096701"/>
    <dbReference type="KEGG" id="sco:SCO1278"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1277"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_11"/>
    <dbReference type="InParanoid" id="Q9K3G3"/>
    <dbReference type="OMA" id="RRDYKRV"/>
    <dbReference type="PhylomeDB" id="Q9K3G3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="103"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB99158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="525" mass="57218" checksum="EE9AA93E6CBDBB58" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M3</accession>
    <name>Q9K3M3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1037</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625332.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977792.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1037"/>
    <dbReference type="GeneID" id="1096460"/>
    <dbReference type="KEGG" id="sco:SCO1037"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1032"/>
    <dbReference type="eggNOG" id="COG1942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3M3"/>
    <dbReference type="OMA" id="PEDDQFM"/>
    <dbReference type="PhylomeDB" id="Q9K3M3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037479">
        <property type="entry name" value="Tauto_MSAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38460">
        <property type="entry name" value="PTHR38460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14552">
        <property type="entry name" value="Tautomerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB96022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14291" checksum="DC9BC27AB2573508" modified="2000-10-01" version="1">MPFVRIDAHGGGTDDDRLDALGRAVHDALVEALGIPPDDRFQVLTAHDAARGTLRYDDYPGVRRDAGIVFVAITLRAGRTTRQKAALYGRIAQLAEEYAGTDPRNVFVTLTENTSADWSLGNGLAQYVGSGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M4</accession>
    <name>Q9K3M4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphotriesterase-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1036</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625331.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027534.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1036"/>
    <dbReference type="GeneID" id="1096459"/>
    <dbReference type="KEGG" id="sco:SCO1036"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1031"/>
    <dbReference type="eggNOG" id="COG1735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054760_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K3M4"/>
    <dbReference type="OMA" id="CHMNPSH"/>
    <dbReference type="PhylomeDB" id="Q9K3M4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB96021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="302" mass="31567" checksum="92B55F5CDE4C7F02" modified="2000-10-01" version="1">MSAVRTVLGDVPGGELGVCDAHDHLFFASPRLPGEELRDAAAARAELAAFREQGGGTVVQWTPYGLGRRAADLPALSRETGVHVVAATGLHQDVHYDQDTLAALRGRAADVFVAELTRGIGTSGVRAGLIKVAGGFHALDAHARWTMSAAAEAHHATGAPIAVHLELGTGALDVLELLCGGAGVPPDRVILGHLNRSPDPVTHRQSAGSGCWLAFDGPSRGNHATDWRMPDAVRDLAEAGFGDRLLLGGDTTAASARSVDGGPGMPYLLRRVAPRLALAVGDELVRRVLTENPARAFAVDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K462</accession>
    <name>Q9K462_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7223</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631279.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971922.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7223"/>
    <dbReference type="DNASU" id="1102661"/>
    <dbReference type="GeneID" id="1102661"/>
    <dbReference type="KEGG" id="sco:SCO7223"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7323"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_11"/>
    <dbReference type="InParanoid" id="Q9K462"/>
    <dbReference type="OMA" id="LMCPWAG"/>
    <dbReference type="PhylomeDB" id="Q9K462"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="373" mass="39155" checksum="587193BCE57C8E3E" modified="2000-10-01" version="1">MTTHVTIVGAGLGGLTLARVLHVHGIPATVHEAEASAKARAQGGMLDIHDSNGQPALRAAGLAEEFRGLVLEGRQASRALAPDGTVLFEEGDDGTGGRPEVMRGELRRMLLDSLPAGTVRWGRKVRAARPLGDGRHEVAFADGTSVVTNLLVGADGAWSRVRPLLSDAAPEYVGMSFVETYLFDADTRHPATAKAVGDGAMFALAPGKAIQAHRESGGTLHAYVALRRPREWFDGIGLPGAAGAARLAREFAGWAPELTALITEADTAPVLRPLYTLPAAHRWERVPGVTLLGDAAHLMPPSGEGANLAMYDGAELGTALAAHSGDVEAALTAYERDLFPRSAAEAADASRLHALMFGDDAPHGLIRMFTGQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4D5</accession>
    <name>ATPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">SCO5371</name>
        <name type="ORF">2SC6G5.15</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973626.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4D5"/>
    <dbReference type="SMR" id="Q9K4D5"/>
    <dbReference type="STRING" id="100226.SCO5371"/>
    <dbReference type="GeneID" id="1100811"/>
    <dbReference type="KEGG" id="sco:SCO5371"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5451"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_11"/>
    <dbReference type="InParanoid" id="Q9K4D5"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="PhylomeDB" id="Q9K4D5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238374" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <sequence length="529" mass="57257" checksum="F041FA73CAD04134" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4I1</accession>
    <name>Q9K4I1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7244</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631300.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031537.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7244"/>
    <dbReference type="GeneID" id="1102682"/>
    <dbReference type="KEGG" id="sco:SCO7244"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7344"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="InParanoid" id="Q9K4I1"/>
    <dbReference type="OMA" id="FYNCFGQ"/>
    <dbReference type="PhylomeDB" id="Q9K4I1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="420"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="505" mass="54462" checksum="DBD7330D4EBE39EB" modified="2000-10-01" version="1">MTPGHGSTGSTGSTVDGVLRRSARRTPARVAVEYRDRSWTYAELDTAVSRAASVLLGEGLSPGDRVAAYGHNSDAYLIAFLACARAGLVHVPANQNLTGEDLAHIVGQSGSTLVLTDPGLASRLPGTTRTLPLRDTDDSLLSRLAATPPYDGPEPGAEDLVQLLYTSGTTALPKGAMMTHRALVHEYLSAITALDLGAGDRPVHALPLYHSAQTHVFLLPYLAVGATNVILDAPDGDRLFDLIEAGRVDSLFAPPTVWIGLANRADFATRDLTGLRKAYYGASIMPVPVLERLRARLPHLAFYNCFGQSEIGPLATVLGPDEHEGRMDSCGRPVLFVDARVVDEDGKDVPDGTPGEVVYRSPQLCDGYWDRPEETEAAFRDGWFHSGDLAVRDADGYYTIVDRVKDVINSGGVLVASRQVEDALYTHDAVAEAAVIALPDERWIEAVTAVVVPRSEVTEDELIAHTRERLTAFKAPKRVLFVDALPRNASGKILKRELRDRFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK7</accession>
    <name>Q9KXK7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2313</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626560.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028273.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2313"/>
    <dbReference type="GeneID" id="1097747"/>
    <dbReference type="KEGG" id="sco:SCO2313"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2350"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_12_1_11"/>
    <dbReference type="InParanoid" id="Q9KXK7"/>
    <dbReference type="OMA" id="GTNRKEC"/>
    <dbReference type="PhylomeDB" id="Q9KXK7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="203"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="33744" checksum="82F52A77C73D83F6" modified="2000-10-01" version="1">MSYTGPDFEPSQPRRSPLRRALTVAVAALVPGALLGWGVYAAVGGPGEGDGGGSGRAGGAGTPAAPSSGAPASGAPASSPGDGDGDGKKPAGSSPAPTSKAPSASGPALPASGPLTGKVVVIDPGHNPANFRHASEINRKVNVGTHWKECDTTGTATNAGWPEAKFTLDVAHRLRTLLQEQGATVKLTQDGDRSFGPCVDERARIGNEAKADAAISIHADGSGAGNRGFHVIMPGSVHDGAADTRAIVAPSAELGERVAGAFVRVTGTAPSNYLGDGTGLVTRTDLGGLNLSTVPKVFIECGNMRDRTDAALLTSGSWRQKAAQGMSEGIVSFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXS7</accession>
    <name>Q9KXS7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4314</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628486.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029573.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4314"/>
    <dbReference type="GeneID" id="1099754"/>
    <dbReference type="KEGG" id="sco:SCO4314"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4382"/>
    <dbReference type="eggNOG" id="ENOG5033Y17">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234432_0_0_11"/>
    <dbReference type="OMA" id="WVHAGDV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="24410" checksum="BBDFC7E521148616" modified="2000-10-01" version="1">MTTPADLHDVRDPELPGRLLMLERDELVPLLRSRADADFALPVAACPGWTVRDVLAHCSSALIRVVDKRFEKGVFSPECNDRDIAERADWSNARIVDELERGMTEAGPVIARSDGRLDAVALGEWVHAGDVRVTFGEPGAYAGRGLAEALALLGTVTRARGHVPLHADLDDLDEPLKLGEASGERPPGRYIGDGPTLLRLYAGRPLDGAAAYELAGVEAAELNIFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXW8</accession>
    <name>Q9KXW8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO4273</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628445.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029546.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4273"/>
    <dbReference type="GeneID" id="1099713"/>
    <dbReference type="KEGG" id="sco:SCO4273"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4340"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KXW8"/>
    <dbReference type="OMA" id="FPGNHHP"/>
    <dbReference type="PhylomeDB" id="Q9KXW8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176747" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="51"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="316"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB93033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="473" mass="51561" checksum="302143BC42093E83" modified="2000-10-01" version="1">MRTPRLLVAAATVVALAACSGGGAVEGTPGGSGVRDPYFPKAGNGGYDIGHYDLRLDYAPDADAGSGAGHLTGTATITARATRDLSAFDLDLKGLDVEEVTVEGRDARFNRAGQELTVRPAEELNDGETFRVTVRYSGEPETITDPDDSEEGWLPTADGAVGLGEPTGSMAWFPGSHHPSDKATYDLAMTVPEGLGVVSNGELRDERTRGGRTTFTWHTAEPMASHVVTVAVGEWETARSTTDDGLPVYTAVDPTQADASRKVLKRIPEIMDWARQNFGPYPFSSTGAIVDRDEDAGYALETQNRPYFPGTPDTVLLVHELAHQWYGNSVSPKTWRDMWLNEGFATYAEWLWEEDHGGDTAQETFEALYDGTYYDDEDANDSIWAFPPADPPDAAHISDSPVYQRGAMVLHKIRETVGDDAFRELLHGWAAAHRHGNADTEDFTAYVERSAPDEDFSEIWADWLRGDGRPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY36</accession>
    <name>Q9KY36_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626601.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028301.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2354"/>
    <dbReference type="GeneID" id="1097788"/>
    <dbReference type="KEGG" id="sco:SCO2354"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2392"/>
    <dbReference type="eggNOG" id="ENOG5030TWP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155283_0_0_11"/>
    <dbReference type="OMA" id="DDNGWRK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="12654" checksum="7D30652C218C2391" modified="2000-10-01" version="1">MATTYDFPSDLLAGQEELHQVRAELSALLKRLPWSVEPLDGFSDDNGWRKVERPASPGWSADEQAEVEKLRQRERELAVFVSTHRYWSEMTGPDQVSARSELKHAHEGPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY37</accession>
    <name>Q9KY37_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2353</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626600.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028300.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2353"/>
    <dbReference type="GeneID" id="1097787"/>
    <dbReference type="KEGG" id="sco:SCO2353"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2391"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102191_0_0_11"/>
    <dbReference type="OMA" id="SNAVCRK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="23743" checksum="4504E756B6A41026" modified="2000-10-01" version="1">MIRLFDFEARVPFGGSRERVARGPARLSDPCPTVKDMDGMDERNAPGGERVCLVPWAEGDLWLLRRTNSPEMTVHLGGPESEERLLARHRRYVEPAPGQMYRVTLADGGETVGSVGYWQRTWRDTEVWETGWGVLPEFQGRGLAVRAARAVREVARTTGTHRYLHAFPGVGHAASNAVCRGAGFTLLGQVDAEYPKGRRIRSNDWRVDLEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY62</accession>
    <name>Q9KY62_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4802</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628959.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4802"/>
    <dbReference type="GeneID" id="1100243"/>
    <dbReference type="KEGG" id="sco:SCO4802"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4878"/>
    <dbReference type="eggNOG" id="COG4715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051328_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KY62"/>
    <dbReference type="OMA" id="KFPCKHG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="39436" checksum="CD9855130DE03A76" modified="2000-10-01" version="1">MIAHRSLSVGGPTFDGMARHGVRRGGEPGRGGDVGTAVRGPGGEGGRGCAEEGTAGPSAPAAASDPEAARRRAERRAERVTAGATELEQRLADLLRTGLAGAEQAGYGLWEETAARMVDAQAPGLASRVRELAAIPSSGPGWPVRLLEECALLHLLDRGWLGRERLPDGLAATVRSRVGLPTSADGPPVRDHWLVLAQYDTADARLTTRRVWLYGAESDRTALLLSYGAAGRAPELTLPVGAELDAEISAYPGPGRQRAALGRRFAPPEPARTRPPGVTTSQAAVRYGAALRDDPWLDSVPVALERVVPVPDGDGWQLADADGDTALPLAWAGGNHPGLWRLVALAGGAPVTVFGECGHRGFTPLTAWPAGPGPAVPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYU8</accession>
    <name>Q9KYU8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3197</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627411.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028823.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3197"/>
    <dbReference type="GeneID" id="1098631"/>
    <dbReference type="KEGG" id="sco:SCO3197"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3257"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYU8"/>
    <dbReference type="OMA" id="GETRSNI"/>
    <dbReference type="PhylomeDB" id="Q9KYU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008443">
        <property type="term" value="F:phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB90981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="31869" checksum="8CDD0B91ADFB2BB4" modified="2000-10-01" version="1">MILTVTPNPSLDRTYEVPSLDRGEVVRATGERVDPGGKGVNVSRAVTAAGRRTVAVLPLGGAPGALVADLLDAQGIEVAPVPITGPTRSNIALAEADGVLTKINAPGPELTPDERELLLETVRRQSPGADWIACCGSLPRGLAPSWYADLVARAHAAGVRIALDTSGPALLRALRERPDVVKPNAEELAEAVGRPLATVGDAVKAAEELRELGARSVLASLGADGQLLVDDAGTWFGTARVDAVRSNVGAGDSSLAGFLVAGGTGPGALASAVAHGAAAVQLPGSVMPTPHDLDPAAVTVTAEVPVDRVLGEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ31</accession>
    <name>Q9KZ31_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2200</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35316">
        <property type="entry name" value="T35316"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626452.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976615.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2200"/>
    <dbReference type="GeneID" id="1097633"/>
    <dbReference type="KEGG" id="sco:SCO2200"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2237"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="InParanoid" id="Q9KZ31"/>
    <dbReference type="OMA" id="FGPTGNI"/>
    <dbReference type="PhylomeDB" id="Q9KZ31"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB90847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="279" mass="29195" checksum="657786C1CCE37406" modified="2000-10-01" version="1">MIVVTGATGNIGRPLTRALAEAGEQVTAVSRHPAAVPDGVRHLVADLAEPAGLRPALTGAKSLFLLLSGDLHALGANPADLIGEAARSGVRRVVLLSTLGVVTRPFGATRIAMRELEDTLRESGLEWAVLRPGGFASNALWWAESVRARRVVAAPFGDVGVPVVDPADIAAVAAACLLEDRHTGGAYELTGPEVITPRGQTEAIAAALGAPVAFHELTREEARTAMARSMPAELADDTLDILGNPSPAELRVSPDIERVLGRAPRPFADWAARNADAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ76</accession>
    <name>Q9KZ76_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amino acid hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3072</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627292.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028750.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3072"/>
    <dbReference type="GeneID" id="1098505"/>
    <dbReference type="KEGG" id="sco:SCO3072"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3132"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024588_6_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ76"/>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="PhylomeDB" id="Q9KZ76"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="405" mass="42722" checksum="B3E6443C2E1A0492" modified="2000-10-01" version="1">MSFHSMWAELLPVGRSSASGGYRRAAWTGADADCRTWFQEQAEARGLTYETDRNGNQWAWLGDPAAGNAVVTGSHLDSVPDGGAFDGPLGVVSAFAALDELRGRGARFTRPLGIVNFGDEEGARFGLACVGSRLTSGALTVEQAHRLTDGDGITLPQAMEAAGYDPGTLGPDPERLARIGAFVELHVEQGRALDLSGDRIGIASAIWPHGRWRFDFRGEANHAGTTRLADRHDPMLPYAETVLAARREAQLAGAVATFGKIGVEPNGVNAVPSLVRGWLDSRAADQASLDTVVTGIEKAAREYAAARGVDLDVVRESFTPVVEFDHALRDELGRILGTGTDLKVPVLGTGAGHDAGILSDRIPTAMLFVRNPTGVSHSPAEYAAEDDCVAGVNALADVLEGLACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ81</accession>
    <name>Q9KZ81_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3064</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Membrane</location>
            <topology evidence="1 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627284.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975747.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3064"/>
    <dbReference type="GeneID" id="1098497"/>
    <dbReference type="KEGG" id="sco:SCO3064"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3124"/>
    <dbReference type="eggNOG" id="COG3104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004790_0_2_11"/>
    <dbReference type="InParanoid" id="Q9KZ81"/>
    <dbReference type="OMA" id="QMMGVWF"/>
    <dbReference type="PhylomeDB" id="Q9KZ81"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="498" mass="53047" checksum="CE1926C49EA0570A" modified="2000-10-01" version="1">MASSLTKDSVTPGTPGTEKTFFGHPRGLATLFMTEMWERFSYYGMRALLPLYLVAPGGLGLGAGTATAIYSVYLSLVYLLTMPGGWFGDRVWGPRKTVAIAGGVIMLGHLTLALPSSGTFYAGLGLVAIGSGLLKANISTMVGQLYDGPDDPRRDGGFTVFYMGINLGAFAAPLTIGTIGENVNWHLGFALAAVGMGLGVLQFLIGSRHLAPHSSAVPKPLSVEEKTSTLRKAAFWAALAVVFYAIVGFSGHYTLNWILVPLTLLGVIIPVLVLTNIKRDKSLDRAEQSKMSAYIWFFVAAAVFWMIYDQGGSTLSLFADSSADNSVFGWSFPVSWYQSVNPVIIMALAPVFATVWLALNRRGKEPSTVVKFCGGLVLVGASFFLFLAPLGIAEGGHKAAAMWLVAIYFVQTCGELMLSPVGLSVTTKMAPVKYASQMMGVWFLAVTAGDATTGLLSIAGVDLNKTGIVAAEATLAVVAGVAIWMYRKRVKELMGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ96</accession>
    <name>Q9KZ96_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4850</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-01" db="PDB data bank">
            <title>The structure of a TetR family transcriptional regulator from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Xu X."/>
                <person name="Zheng H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A.M."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629005.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029905.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="PDB" id="3C07">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.70 A"/>
        <property type="chains" value="A/B=1-251"/>
    </dbReference>
    <dbReference type="PDBsum" id="3C07"/>
    <dbReference type="SMR" id="Q9KZ96"/>
    <dbReference type="STRING" id="100226.SCO4850"/>
    <dbReference type="GeneID" id="1100291"/>
    <dbReference type="KEGG" id="sco:SCO4850"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4928"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072073_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ96"/>
    <dbReference type="OMA" id="HEFAVQF"/>
    <dbReference type="PhylomeDB" id="Q9KZ96"/>
    <dbReference type="EvolutionaryTrace" id="Q9KZ96"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3C07"/>
        </source>
    </evidence>
    <sequence length="251" mass="28274" checksum="192FB5692B2E7A08" modified="2000-10-01" version="1">MPATNDGPDDGAHLSKSEQTRALILETAMRLFQERGYDRTTMRAIAQEAGVSVGNAYYYFAGKEHLIQGFYDRIAAEHRAAVREVLARETDLEARLAGVLKVWLDIATPYHEFAVQFFKNAADPDSPLSPFSPESEHARVEAIGIHRAVLAGAKTKVPEELRDILPELMWLSQMGLVLYWIFDRTEGRERSYRLAERGARLTARGVVLARFRVLRPLVREVHELFTDFLPGMTKVMPDPAKKPTRDAGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZW6</accession>
    <name>Q9KZW6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628312.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029457.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4135"/>
    <dbReference type="GeneID" id="1099575"/>
    <dbReference type="KEGG" id="sco:SCO4135"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4198"/>
    <dbReference type="eggNOG" id="ENOG50333DA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066641_0_0_11"/>
    <dbReference type="OMA" id="VPADKWV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="30690" checksum="E26A9A130B47CA4E" modified="2000-10-01" version="1">MVGRERELRSGWAGGGPALAGGAVCVCLALAGCSGSGQGASVQGAGGGDPVAVLHRAADRLVAAGSAKARTAMQMASGGTRVTIRGEGVYDFEERLGQLKVRLPQDPAGTSEHRPITELLAPGALFMKNRGAGVPDDKWVRVETDSLSDGNLVTGGATDPFAAAEVLRGTRTATFVGRTELAGTEVRHYRGTADLARAARGASAGNRKALAAAAQGFATAQVPFDAYLDDQGRIRKVRHRFSFANGQEDGTGIVDVASTTLLYDFGAAVRVRLPEDQDIYAGKIAAEPGERGVDGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L034</accession>
    <name>Q9L034_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7021</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031385.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7021"/>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="GeneID" id="1102459"/>
    <dbReference type="KEGG" id="sco:SCO7021"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7125"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L034"/>
    <dbReference type="OMA" id="NDATHVG"/>
    <dbReference type="PhylomeDB" id="Q9L034"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176793" evidence="4">
        <location>
            <begin position="33"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="251"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="367" mass="38587" checksum="50892C29CC7FD76B" modified="2000-10-01" version="1">MNVSTGGRRIWSRGATAALACAIILLPGPGYAAPGDPDPHTDKSIEDIRDELDGLYREAEVATEAYNAANEKAAKQEKRLTTLRKDLTRAEKRVKDLRDLAGAAARTQYRGGDLAATGIQLLLGDHPEQALDEASQARQAMRGLVNVSETQKTAREALSEQTEAASKELRELKSSRADKAAAKQKIEKKIASAERIEAGLEEEQTRRLAALERQRSREAEVRWTESGGSSAGSAGKGKGKGRAPGGGTQVSGAAGKAVGFAMAQIGKPYVWGAVGPSSYDCSGLTSAAWAAAGHPIPRTSQAQWGGLTRVSLSSARPGDLIIYYNDATHVGMYIGGGQIVHAPRPGRDITTAPAASMPVLGVVRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L039</accession>
    <name>Q9L039_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative LacI-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7016</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631080.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031380.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7016"/>
    <dbReference type="GeneID" id="1102454"/>
    <dbReference type="KEGG" id="sco:SCO7016"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7118"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="InParanoid" id="Q9L039"/>
    <dbReference type="OMA" id="DGLIFCS"/>
    <dbReference type="PhylomeDB" id="Q9L039"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="35847" checksum="9A7C149619820F79" modified="2000-10-01" version="1">MTRRLAQVAKKVGVSEATVSRVLNGKPGVSETTRQSVLSALDVLGYERPTQLRGERSRLVGLVLPELQNPIFPAFAEVIGGALAQQGLTPVLCTQTKGGVSEADYVELLLQQQVSGVVFAGGLFAQADAPHDHYRLLAERNIPVVLINASIENLDFPCIACDDAVAVEQSWRHLASLGHERIGLVLGPSDHIPSRRKLAAAREAARAAGAELPEEFVERAMFSLEGGQAAATRLLDRGITGIICASDPLALGAVRAARRRGHRVPHDVSVVGYDDSAFMTCTEPPLTTVRQPIEAMGRAAVDLLCAQIQGTEVPHGELLFEPELVVRGSTAQPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L092</accession>
    <name>Q9L092_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO2454</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
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                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
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    <dbReference type="KEGG" id="sco:SCO2454"/>
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    <sequence length="743" mass="77473" checksum="7FAF0A35D021489E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
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                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
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                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="PubMed" id="12000953"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="CAB76293.1"/>
        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
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                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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                <person name="Taylor K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO2959"/>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
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        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="116"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="140"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB72205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="452" mass="47765" checksum="84CFC17D1C2464F9" modified="2000-10-01" version="1">MKARGGRWIEYWDPENETFWKETGRRTARRNLFFSVLSEHIGFSVWTLWSVLVLFMGPEYGLSPADKFLLTSVVTLVGAVVRVPYTFAVAVFGGRNWTVVSASMLLVPTLAAFVVMEPGTSFSTFLLVGLLAGIGGGNFASSMTNINAFFPLREKGWALGLNAGGGNVGVPVIQLVALAIIGASGGPRVLLGIYIPLILVAAVLAARFMDNLTTVKNDTGAAKDAARDAHTWIMSVLYVGTFGSFIGYSFAFGQVLTTQFGRTPLQAAYLTFIGPLLGSLVRPLGGRLADRYGGSRITLWNFVAMAAATAVLVVASMERSLALFVTVFVALFVLSGLGNGSTFKMIPHIFHSKALARGLTGEEAVLHGRRLSGAAMGLIGAVGGLGGVGINLAFRQSFLSSGSGTGAFVAFLACYAVCIAVTWSVYLRRPAGRSGTGAGPAAEETRRSYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1V6</accession>
    <name>Q9L1V6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6829</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630900.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031214.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102268"/>
    <dbReference type="KEGG" id="sco:SCO6829"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6939"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="InParanoid" id="Q9L1V6"/>
    <dbReference type="OMA" id="ERKFDGH"/>
    <dbReference type="PhylomeDB" id="Q9L1V6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="27452" checksum="14E2DE57CFCCBE4F" modified="2000-10-01" version="1">MRTADTQAARTRTAVVTGASSGIGAATARALAREGFEVVLTARRADRLEAVAKEIRNDGGMVQVFPLDVTDREAVLAFAAQFPACDVLVNNAGGAYGTEHIENADPGDWRSMYEVNVIGALHMTQALLPALKASGDGVVVVISSTASFTCYEGGGGYSAAKHGAHVLAETLRLEVCGEALRVVEIAPGMVHTEEFSLNRYRGDLNRADAVYAGVPDPLVADDVADVVTWAVTRPPHVNIDLLVVRPRAQAAQHKVHRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Z8</accession>
    <name>Q9L1Z8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative serine protease (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO2637</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626873.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028469.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2637"/>
    <dbReference type="MEROPS" id="S08.026"/>
    <dbReference type="GeneID" id="1098071"/>
    <dbReference type="KEGG" id="sco:SCO2637"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2684"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282117_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1Z8"/>
    <dbReference type="OMA" id="WVTATDP"/>
    <dbReference type="PhylomeDB" id="Q9L1Z8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176832" evidence="7">
        <location>
            <begin position="41"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="203"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="PPC" evidence="9">
        <location>
            <begin position="948"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB71812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1098" mass="114303" checksum="4721BB5A83F41839" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCW2</accession>
    <name>Q9RCW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0849</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625149.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027389.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0849"/>
    <dbReference type="GeneID" id="1096272"/>
    <dbReference type="KEGG" id="sco:SCO0849"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.841"/>
    <dbReference type="eggNOG" id="COG1981">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114403_0_0_11"/>
    <dbReference type="OMA" id="KFWLTLA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004336495" evidence="2">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="18197" checksum="FB8019102ACE6EBF" modified="2000-05-01" version="1">MKLGRPARRASLVVHVVASAAWLGLTLGLLALGVTAATAASPVAVDAAVRCMKLFADWLLLPLALLTLVSGLVLALGTPWGLARYRWVYTKFWLTLGTTVATFFALRPGVNAAAAAAAAGRPLPDAGDVLFGPVVSLSAYVFMTVLSLLKPWGLTRRGRRPRERPSAAPPPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD58</accession>
    <name>Q9RD58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624935.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027255.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0624"/>
    <dbReference type="DNASU" id="1096047"/>
    <dbReference type="GeneID" id="1096047"/>
    <dbReference type="KEGG" id="sco:SCO0624"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.606"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844450_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RD58"/>
    <dbReference type="OMA" id="MFYMANE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176862" evidence="1">
        <location>
            <begin position="35"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="334" mass="36738" checksum="AEE5E11D5EC92728" modified="2000-05-01" version="1">MHEPHLDRRLFLKGTAVTGAALALGATAAPTASAAPGGFPDYTYVRTLLTPSQLAYNPTGEIIFPTVRGVYDRLPASGRLGRYYLYYAPHDAPGGICLAYGDSLEGPFTEYPHNPIVSNKWSPHYSVSHVSSPHVMWHAGRKEMWLYFHGENTTTRLARSTDGIHFTYDKVVLNTSMLPSGTTETSYARVFPHELPSRGAHYVMVFMVNNTTNHRDIGWGWSADGRTWTFAQEPLVRHGDVGAVNVGGPHLLHRNNSTYVVYNKDKESGGDLMITEVGNDFSLRRHLGVFYDSRASAPENGRAASPSFGTDRGVPYMIYEAGERLAGSIAMARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS0</accession>
    <name>Q9RDS0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626496.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2247"/>
    <dbReference type="GeneID" id="1097680"/>
    <dbReference type="KEGG" id="sco:SCO2247"/>
    <dbReference type="HOGENOM" id="CLU_2920631_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="61" mass="6783" checksum="E4548F4EE9C9240F" modified="2000-05-01" version="1">MAENLPREIPDRLIPATPPRDRISERPRTGEPLTLSGAAGTAPHVRVTQWPYPGTEQVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS2</accession>
    <name>Q9RDS2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2245</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626494.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976568.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2245"/>
    <dbReference type="GeneID" id="1097678"/>
    <dbReference type="KEGG" id="sco:SCO2245"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2283"/>
    <dbReference type="HOGENOM" id="CLU_131550_2_1_11"/>
    <dbReference type="OMA" id="HIPADAW"/>
    <dbReference type="PhylomeDB" id="Q9RDS2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="7391" checksum="316DDE41BC17B958" modified="2000-05-01" version="1">MTGKDTPVHPADLAWFKSSYSDTSEPSDCVEVAATPAAVHIRDSKRPDGPRLAVDSVTWTMFVAGTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI54</accession>
    <name>Q9RI54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0192</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37023">
        <property type="entry name" value="T37023"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624527.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026916.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0192"/>
    <dbReference type="DNASU" id="1095616"/>
    <dbReference type="GeneID" id="1095616"/>
    <dbReference type="KEGG" id="sco:SCO0192"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.165"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039679_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RI54"/>
    <dbReference type="OMA" id="WSSIQGA"/>
    <dbReference type="PhylomeDB" id="Q9RI54"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="416" mass="43641" checksum="7B897556A7D70AED" modified="2000-05-01" version="1">MSDGQHRAADAVVVGAGLAGLACALDLCRAGWRVALLEASDGVGGRMRTDRRDGFLLDRGFQVFNTSYPQVKRRMELKSLRLRPFTAGVVAHTSNGPVRLADPTREPRAAGTLLPGRALPARDLAALAALTARDAVLPVAVTRRRRDRPTSAALSRVGLSDAAIAGILRPFLSGVFLEDRLETSARFFHLVWRSMVRGSLCLPAEGIGAVPAQLADGLPDGVLRLGTPVAEITDAGVLLGDGGEVPARVVVVATDPATAAGLLPDLTVPDTRTVTTYYHATDSPPTAEPILMVDSTGAILNTCVLSQVAPTYAPPGTGLVSTSVLGTDPPGRAQAVLRRLAELYGTDTSGWEQVAARTVDGALPAMLPPWPLSRTTRIGPGRYVCGDHRATGSVQGALASGTRAAREVRADREPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJA2</accession>
    <name>Q9RJA2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding protein dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0662</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624971.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978200.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0662"/>
    <dbReference type="GeneID" id="1096085"/>
    <dbReference type="KEGG" id="sco:SCO0662"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.646"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="OMA" id="AFDKYRF"/>
    <dbReference type="PhylomeDB" id="Q9RJA2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="80"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="31533" checksum="77AB4EDEC0FFA6CF" modified="2000-05-01" version="1">MSATDSSLLRPKLLGRATVNVVVAVSVLYTLLPVLWLVLASTKNRDALFSSDLLSLSDFSLLQNLKDLFAMDGGLYGRWYVNSLLYAVIGAAVGALVSVACGYAFDKYRFRHKEKLFGLVLAAVMVPQTVLALPLYLMASEAGLVNTFWAVFIPVLFNPFGVYLGRIFARGYVPDEVLEAARVDGAGELTTYARVAFRMLGPGLITVFLFQLTAIWNNFFLPMVMLSDQDLYPVSLGLYQWNSSASVSPEYYPVVIMGSLLAVLPLILAFVLLQRFWRSGLTAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJH6</accession>
    <name>Q9RJH6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0564</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB57416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624877.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978298.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0564"/>
    <dbReference type="GeneID" id="1095987"/>
    <dbReference type="KEGG" id="sco:SCO0564"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.545"/>
    <dbReference type="eggNOG" id="ENOG502ZETH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049598_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJH6"/>
    <dbReference type="OMA" id="EDMIGGQ"/>
    <dbReference type="PhylomeDB" id="Q9RJH6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="93"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB57416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="386" mass="43025" checksum="D0B4AB2E88D9D534" modified="2000-05-01" version="1">MPHTEKSMDALRRSGDELADAVVATLFERGEVGTFNALMRYVSTTGQDLPDGLPGVAREYLRVTGTPPDWVDWAEMERARLFFIDNNVHISTALSFASMPACYLVPHVARLLSATHGLNYPSKRMAETGQFTVYLMRPDAFESGGRFVPAAQKVRLLHAAIRHHLKREDRWDTDTLGVPICQEDMIGGQMFFSLLVLDSLHRLGIHMSAEGADAYYYAWRVVGAMLGVDQAAVPATLDEARRFLDLYMLRHMGPSEEGAHLTRQLIDLYEEVVPGTLFDPVVSALIRYLVGDTCADWLDVPRTTWDTLVKAAPHLLGVLETIEDRSPLGAWALDRLGHLTTALELSSLTRGRVMHYAIPEQLRKEYGVSGAAARTRRWTPPPPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK4</accession>
    <name>Q9RJK4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0384</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624706.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027073.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0384"/>
    <dbReference type="GeneID" id="1095807"/>
    <dbReference type="KEGG" id="sco:SCO0384"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.360"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613446_0_0_11"/>
    <dbReference type="OMA" id="LPGQWEE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB58325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="45295" checksum="CF8A853301C2302F" modified="2000-05-01" version="1">MVGALAGYGVSVLFPPRYTASASVLLPGQWEQRELVTQVEIATSSAVVDRAADELRWNGVGRSELRDRVSAETADGNIVKISGTAATPERAQRLSDEVAQQFVTYAARIASGTTGADEAAGPEALREQVTRTNRRITDLANAADPGQTVESVQARTELEKLRSALQDAMQKLEEADPANNRAGMVVMGPAARPAGEAPPTRLQLIGGGALLFFVLAVIAHLTAARVNRRPRSESEIAAALGTALLGTVDVPGDRRAHRPKARGAQARFRRLLGVDVRWDLPTPRSSGDEAGRRLRYRRVRARLRERVPTARRLLVVVPDDDEVARRAAGRLAADAEDDPRLRVVEVSVARPIVPDRDTESGALVVLSAGARTAEELAGVAEACADGGHEVVGVVVAGAVRARPTASADEPRGDAAAGAAVHDHATGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJR1</accession>
    <name>Q9RJR1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0579</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624891.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027217.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0579"/>
    <dbReference type="GeneID" id="1096002"/>
    <dbReference type="KEGG" id="sco:SCO0579"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.560"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJR1"/>
    <dbReference type="OMA" id="QKMEFKK"/>
    <dbReference type="PhylomeDB" id="Q9RJR1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="17577" checksum="5F17CEC8F8C84DF1" modified="2000-05-01" version="1">MTDKLRIVVGSDDAGHQYKEALKQDLRGSALVAEVTDVGVDADGHTAYPKVAIAAAEMVARGEADRALLVCGTGLGVAIAANKVRGIRAVTAHDSFSVERAILSNNAQVLTFGQRVVGLELARRLAAEWLTYRFDENSASAAKVQLMSDYETADDAGAASGSAADGGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK51</accession>
    <name>Q9RK51_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0326</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624652.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027021.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0326"/>
    <dbReference type="GeneID" id="1095750"/>
    <dbReference type="KEGG" id="sco:SCO0326"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.300"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033093_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RK51"/>
    <dbReference type="OMA" id="PAKYHTH"/>
    <dbReference type="PhylomeDB" id="Q9RK51"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="PTHR37489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="35340" checksum="DD55BB0480090638" modified="2000-05-01" version="1">MSGIPSQGVASGMREAARALLAVLEPEQVRELRAGPDRLDTPELREWTYLPGPRPGLSTEGLDGRQREVVDALLTTAHSAAGAELVRGAIEVERHPRARAGHPGPDRYWVRLLGDPGGDEPWGWRLNGHHLAVHVLVTAAGVRVTPHFVGAEPARTGNGPRPGLRPLGPEEDLARELITSLGGTARASALFAATPPDDILTRADPFADPGLLPEGLRYDRLAPGQQRLLERLVGRYLDRAPEAYARECWSDAVRRGLGSLSFAWAGGLAPGDRHYYCVRAPDFLIEYDNTQDDGNHAHSVWRHVRHDWGTDLLRGHYTEQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKI6</accession>
    <name>Q9RKI6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627650.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028987.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3446"/>
    <dbReference type="DNASU" id="1098883"/>
    <dbReference type="GeneID" id="1098883"/>
    <dbReference type="KEGG" id="sco:SCO3446"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RKI6"/>
    <dbReference type="OMA" id="TLWGPYE"/>
    <dbReference type="PhylomeDB" id="Q9RKI6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02588">
        <property type="entry name" value="HAD_L2-DEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="24364" checksum="5E225AB6E77F9331" modified="2000-05-01" version="1">MPRQNAPLLVFDVNETLSDMSPLQSRFAEIGAPPHLFHLWFAGVLRDGFALTAAGAFSDFSAVAREGVRALLSSAPEWSGDIEQAAGHVVDGLSHLEVHPDVPDGIRALRERGFRLVTMTNGSSDLSKRLLGRAGLADCFESHLDASGPQRWKPAQAAYQYVVEQVGVRLDEAVLVAVHPWDVDGAQRAGLGGAWLRRDAADYPQVMLPPTYTVGNLRELAETLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKX1</accession>
    <name>Y1412_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative hydro-lyase SCO1412</fullName>
            <ecNumber evidence="1">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1412</name>
        <name type="ORF">SC6D7.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625694.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027775.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKX1"/>
    <dbReference type="SMR" id="Q9RKX1"/>
    <dbReference type="STRING" id="100226.SCO1412"/>
    <dbReference type="GeneID" id="1096838"/>
    <dbReference type="KEGG" id="sco:SCO1412"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1422"/>
    <dbReference type="eggNOG" id="COG4336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059759_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKX1"/>
    <dbReference type="OMA" id="NVPMYKT"/>
    <dbReference type="PhylomeDB" id="Q9RKX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01830">
        <property type="entry name" value="Hydro_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016938">
        <property type="entry name" value="UPF0317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="DUF1445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029755">
        <property type="entry name" value="UCP029755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="SSF160920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000217173" description="Putative hydro-lyase SCO1412">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01830"/>
        </source>
    </evidence>
    <sequence length="277" mass="30254" checksum="446F8F2A5899AFC9" modified="2000-05-01" version="1">MNRPHSATGDRPLALVDEHAHAWSPKTARARFRKGLTGPTAGVAAGHTQANLISVPADWAYDMLLFCTRNPQPCPVLDVTDAGSWTTVLADGADLRTDLPRYRVWRDGELVDEPSDVREHWRDDLVTFLIGCSFTFEWALAAAGVPIRHVEQGRNVPMYVTSRACRPAGRLRGPMVVSMRPVPPAHLSAAIHESSLLPAVHGSPVHCGDPSALGIDDLDRPDFGEAVYREPDDIPVFWACGVTPQAAVMASRPPFALTHAPGQMFLTDARDEQYRVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1X8</accession>
    <name>NHAA1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Na(+)/H(+) antiporter NhaA 1/4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sodium/proton antiporter NhaA 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nhaA1</name>
        <name type="ordered locus">SCO0015</name>
        <name type="ORF">SCJ30.11c</name>
    </gene>
    <gene>
        <name evidence="1" type="primary">nhaA4</name>
        <name type="ordered locus">SCO7832</name>
        <name type="ORF">SC8E7.29</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29252"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37078">
        <property type="entry name" value="T37078"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624376.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631860.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026778.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S1X8"/>
    <dbReference type="SMR" id="Q9S1X8"/>
    <dbReference type="TCDB" id="2.A.33.1.6">
        <property type="family name" value="the nhaa na(+):h(+) antiporter (nhaa) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1095436"/>
    <dbReference type="GeneID" id="1103270"/>
    <dbReference type="KEGG" id="sco:SCO0015"/>
    <dbReference type="KEGG" id="sco:SCO7832"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.14"/>
    <dbReference type="eggNOG" id="COG3004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015803_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S1X8"/>
    <dbReference type="OMA" id="LHFITND"/>
    <dbReference type="PhylomeDB" id="Q9S1X8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0739">Sodium transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000334447" description="Na(+)/H(+) antiporter NhaA 1/4">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <sequence length="410" mass="41975" checksum="FEC7D5631FBDC133" modified="2000-05-01" version="1">MSAPSRITAALRSDAVGGSLLIGAAVIALIWANSPLSHSYEALRSFTFGPSALHLNLSVETWAADGLLAVFFFIVGNELKQELVHGELRDPRRAALPIAAALGGVAVPALVFLAFTLGSGGEAAGGWGIPMATGIAFAVAVLAVVGRHLPTPLRTFLLTLATVDDMSAVLVIAVACTSGINFTALALAAVGLAVFGYLQNGSGRAVARVRAMVPAWLLFVPLAAVVWALMHACGVHATIAGVVMGLLMRTRPQGAERVSPSHRAEEVLRPFSAGIALPLFALMSAGVSLAGAGGFVTSAITWNVLAGLLVGKVVGIFGGTWPTSRLTSAHLNPLLGWADIAGIAVLGGIGFTVSLPIAELSSTSQAHLTDAKGAILLASTTAALLAALLLGRRSRHHQRLARQAAQQATT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S224</accession>
    <name>PYRG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">SCO1776</name>
        <name type="ORF">SCI51.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36879">
        <property type="entry name" value="T36879"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626047.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027968.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S224"/>
    <dbReference type="SMR" id="Q9S224"/>
    <dbReference type="STRING" id="100226.SCO1776"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="GeneID" id="1097207"/>
    <dbReference type="KEGG" id="sco:SCO1776"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1793"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_11"/>
    <dbReference type="InParanoid" id="Q9S224"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="PhylomeDB" id="Q9S224"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138232" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="301"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="549" mass="60131" checksum="E30921343E435C38" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S230</accession>
    <name>Q9S230_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1770</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36873">
        <property type="entry name" value="T36873"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626041.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027965.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1770"/>
    <dbReference type="GeneID" id="1097201"/>
    <dbReference type="KEGG" id="sco:SCO1770"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1787"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S230"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="PhylomeDB" id="Q9S230"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="29595" checksum="2C52F41E6BF023EF" modified="2000-05-01" version="1">MRLANFEGPFDLLLQLISKHKLDVTEVALSKVTDEFMAHIRAMGPDWDLDQTTEFLVVAATLLDLKAARLLPAAEVEDEADLALLEARDLLFARLLQYRAYKQIAEIFNDRLEAEARRHPRTVGLEPHHAELLPEVVISIGPEGFAKLAVKAMQPKPRPQVYVEHIHAPLVSVQEQAGIVVARLKELGEASFRVLVQDTEDTLTVVARFLALLELYREKAVELDQETALGDLLVRWTGGDGEAQPSVTDEFDRPPEVPKEERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S246</accession>
    <name>Q9S246_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1706</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36807">
        <property type="entry name" value="T36807"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625980.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027930.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1706"/>
    <dbReference type="GeneID" id="1097137"/>
    <dbReference type="KEGG" id="sco:SCO1706"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1724"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_11"/>
    <dbReference type="InParanoid" id="Q9S246"/>
    <dbReference type="OMA" id="RRMDTGQ"/>
    <dbReference type="PhylomeDB" id="Q9S246"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB46804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="462" mass="47948" checksum="C0DEF507A7323E1E" modified="2000-05-01" version="1">MKAHDGMYIDGAWRPADGRDTIDVVNPVDEQVIGKVPAGSALDVDTAVRAARAALSGWAATPPAERAARLAALRDVLVARKDEIAETVTAELGSPLKFSQAVHAGAPIAVAGSYAELAATHAFEEKVGNSVVHHEPVGVVGAITPWNYPLHQIVAKAAPALAAGCTMVLKPAEDAPLVAQLFAEAVHEAGIPAGVFNLVTGLGPVAGQALVEHPGVDLVSFTGSTAVGRRIGATAGAAVKRVALELGGKSANVILPSADLAKAVNVGVANVMSNSGQTCSAWTRMLVHRDQYDEAVSLAAEAAAKYGDRIGPVVNAEQRERVRGYIGKGVAEGARLVAGGPEAPREQGYFVSPTVFADVTEEMTIAQEEIFGPVLSILRYEDEDDALRIANGTVYGLAGAVWAGDEADAVAFARRMDTGQVDINGGRFNPLAPFGGYKQSGVGRELGAHGLTEYLQTKSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2B3</accession>
    <name>Q9S2B3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type_ISP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1717</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36739">
        <property type="entry name" value="T36739"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625990.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027937.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1717"/>
    <dbReference type="GeneID" id="1097148"/>
    <dbReference type="KEGG" id="sco:SCO1717"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1734"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709626_0_0_11"/>
    <dbReference type="OMA" id="WSVAPPR"/>
    <dbReference type="PhylomeDB" id="Q9S2B3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041635">
        <property type="entry name" value="Type_ISP_LLaBIII_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18135">
        <property type="entry name" value="Type_ISP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Type_ISP_C" evidence="2">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB50932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="391" mass="42564" checksum="9514BF5A2DCAA9A1" modified="2000-05-01" version="1">MPRRTMPGVTHDDAPPLADLMPWSVAPPRLGRGWPTAPDAASLKARWDALLKAEGPDRAALFEPTRSRTPYSAVGRLPGGAGGTERLVRAAGPCPEPVRVLRAPFDEQWLIPDHRLIDAARPELWRVADARQVFVVEAPEAAGGPQLLATSLLPLFGPARIRPLYRRPGGAEPNLAPGLPDHLAARLGRRPAPLDVLAWSAAAVRPGSLVPLTADPALWEHGVELGRRALWLMRRDGERPKLPGGRRPYVRAPLPPRPLVLRYDREEEALFLDEGRISPVPPGAWDFEVGGVRVLEQWFAARAAEGEPGTLTAIRPAGWPQSWTSELLELITVLALLAEVREECRELTVTDEITATELREAGVLPVPGAARRPASVLDDREEGPEGQLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2F5</accession>
    <name>Q9S2F5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36149">
        <property type="entry name" value="T36149"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627152.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028666.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2926"/>
    <dbReference type="GeneID" id="1098359"/>
    <dbReference type="KEGG" id="sco:SCO2926"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2984"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026568_1_0_11"/>
    <dbReference type="OMA" id="YEADHGD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004333268" evidence="2">
        <location>
            <begin position="24"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB51007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="451" mass="47120" checksum="B20ED77382611A0E" modified="2000-05-01" version="1">MLIASVAGAAVLGGVLVLLPRGAGDAPPPAPGPAALARGAVTTGVPAALPDLAALIGDRETHLRAHPLDGASWAVLGAAYVEQGRRTADGANWPKAEKALRTSLRTGPKRNPQALEGLAALAVARRDFPAAKKWGESAVKAAPKRWTAHAVLIGAYTGLGDDKGVGRALDKVMELRPGSAAVGALAAAVYRDRGWREDAAARISDAAAAAGAPAERAAYLEQAGRLAFERGERQEALRFFQEALRTDPDQRAAQAGQGRALAALGRTTEALSAYQAALAKRPSPEYALELGELYESLGLGQAARVEYDLLRERARGAEAAGADEQLVLGLLDADHGDPAAAVERLRVEWGRQPGTAVADALGWALHRTGADEEALEFATIATDGDKGGGVRSALYVFHRGVVEKELGRYGPARRHLGEALTINPYFSPLRVPEAKRALAELGEPPVEGPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2K9</accession>
    <name>Q9S2K9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1994</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35739">
        <property type="entry name" value="T35739"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626255.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1994"/>
    <dbReference type="GeneID" id="1097428"/>
    <dbReference type="KEGG" id="sco:SCO1994"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2021"/>
    <dbReference type="eggNOG" id="ENOG5033D65">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164096_1_0_11"/>
    <dbReference type="OMA" id="RQGPHYQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045924">
        <property type="entry name" value="DUF6343"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19870">
        <property type="entry name" value="DUF6343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="118" mass="13372" checksum="FD8C07A58E066132" modified="2000-05-01" version="1">MNARRPVVRSVRGHASFPPRRAPQYVRYRDGDPMRTGSEPATARSALRARFWLSLWGLVWAIFGTAVFALTGHFGWALACGVLWLVVTADLTVILRHLRQGPHYQPGRDVPPYLPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2R8</accession>
    <name>Q9S2R8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2168</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35284">
        <property type="entry name" value="T35284"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626421.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028172.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2168"/>
    <dbReference type="DNASU" id="1097601"/>
    <dbReference type="GeneID" id="1097601"/>
    <dbReference type="KEGG" id="sco:SCO2168"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2205"/>
    <dbReference type="eggNOG" id="COG1842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056466_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2R8"/>
    <dbReference type="OMA" id="MIFRAKA"/>
    <dbReference type="PhylomeDB" id="Q9S2R8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="39"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="28435" checksum="8C2E379136CAEFBE" modified="2000-05-01" version="1">MIFRAKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLNQLQSQSGKLEDQGRKALALGREDLAREALSRRAALQQQVTDLETQHATLQGEEEKLTLAAQRLQAKVDAFRTKKETIKATYTAAQAQTRIGEAFSGISEEMGDVGLAIQRAEDKTAQLQARAGAIDELLASGALDDQSGMHKDDIQAELDRLSGGTDVELELQRMKAELAGGSTSDRQAIEGGQGQGEASSQSQQPQDTPRFDKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2W7</accession>
    <name>MURE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="1">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murE</name>
        <name type="ordered locus">SCO2089</name>
        <name type="ORF">SC4A10.22c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34959">
        <property type="entry name" value="T34959"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626348.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028131.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2W7"/>
    <dbReference type="SMR" id="Q9S2W7"/>
    <dbReference type="STRING" id="100226.SCO2089"/>
    <dbReference type="PRIDE" id="Q9S2W7"/>
    <dbReference type="GeneID" id="1097523"/>
    <dbReference type="KEGG" id="sco:SCO2089"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2122"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_11"/>
    <dbReference type="InParanoid" id="Q9S2W7"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="PhylomeDB" id="Q9S2W7"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000101951" description="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif">
        <location>
            <begin position="419"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="419"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <sequence length="506" mass="52829" checksum="EEBCACE1FD03A5BA" modified="2000-05-01" version="1">MTYPGPPRPVRISATPLAELADQLGVAAPDGSAEITGITHDSRAVRPGDLYAALPGARLHGADFVTQAAGLGAAAVLTDPAGAERAAAAGLPALVVDDPRARMGELAATIYGHPGRDLLQIGITGTSGKTTTAYLVEGGLRTAKSTGLIGTVEMRIGDERIKSERTTPEATDLQALFAVMRERGTEAVAMEVSSHALVLGRVDACVFDIAVFTNLSPEHMEFHSGMEDYFQAKAQLFTPKRSRLGVVNVDDEYGRRLAKEATVPVVTYSAEGHPDADWRADEVEVGPLDSTFTVLGPKGERIAAKSPLAGPFNVANTLAAIVALAAAGLDPQSAADGVAAVPGVPGRLERVDEGQPFFAVVDYAHKTDAVESVLRALRKVTEGKLHAVLGCGGDRDTTKREPMGAAVARFADTAVLTSDNPRSEDPLAILATMLQGAASVPAHERGEVQVFEDRAAAIAAAVARAEPGDTVLVAGKGHEQGQDIAGVVRPFDDRQVLREAIKKTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2X8</accession>
    <name>Q9S2X8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2073</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34943">
        <property type="entry name" value="T34943"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626332.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976742.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2073"/>
    <dbReference type="GeneID" id="1097507"/>
    <dbReference type="KEGG" id="sco:SCO2073"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2105"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_11"/>
    <dbReference type="InParanoid" id="Q9S2X8"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="PhylomeDB" id="Q9S2X8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="93"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB51982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="34089" checksum="C77669F0D8B1FF85" modified="2000-05-01" version="1">MSTIPEIRTLPVPDGLEGERVDAAISRMFGFSRTKAAELAAAGKVQVDGSVVGKSERVHGGAWLEVEMPQAPAPVQVVAEPVEGMEIVHDDEDVVVVVKPVGVAAHPSPGWSGPTVIGGLAAAGYRVSTSGAAERQGIVHRLDVGTSGLMAVAKSERAYTSLKRQFKERTVDKRYHTLVQGHPDPTSGTIDAPIGRHPQHDYKWAVTAEGKPSVTHYDLIEAFRAASLLDVKLETGRTHQIRVHMAAHRHPCVGDLTYGADPTLAKRLRLTRQWLHAVRLGFEHPGTGDWVEYASEYPDDLQQALDLVREETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Y9</accession>
    <name>Q9S2Y9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative glutamate synthase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">SCO2026</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34869">
        <property type="entry name" value="T34869"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626286.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028104.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S2Y9"/>
    <dbReference type="STRING" id="100226.SCO2026"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="GeneID" id="1097460"/>
    <dbReference type="KEGG" id="sco:SCO2026"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2056"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_11"/>
    <dbReference type="InParanoid" id="Q9S2Y9"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="PhylomeDB" id="Q9S2Y9"/>
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        <property type="reaction ID" value="UER00399"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:ammonia assimilation cycle"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="15">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAB52861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1514" mass="162911" checksum="CDE1AB4A3A763B05" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX19</accession>
    <name>Q9WX19_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3315</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36263"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975521.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3315"/>
    <dbReference type="GeneID" id="1098749"/>
    <dbReference type="KEGG" id="sco:SCO3315"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3375"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_0_11"/>
    <dbReference type="InParanoid" id="Q9WX19"/>
    <dbReference type="OMA" id="RRLVGHM"/>
    <dbReference type="PhylomeDB" id="Q9WX19"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="24904" checksum="AAAF834FB942E90B" modified="1999-11-01" version="1">MPDQPSHNPAEHTTGEAPAPDALRADARRNRERVLEAAREVFSARGVDAPMSAVARRAGVGVATLYRRFPTRSSLVAAAFDDQLTVCAAAFDEALADPDPGHGLYTLLRKVCTTLVTDRGFETVFMAGFPASLDYDRERACAEERLAHLVRRARDAGRLREDFSPADIPLLLLAVSGLASQPPETAVPAAHRLLTYLFQSFQADPPPRPAPLPPAPTLDLSGLHRPAERP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7V3</accession>
    <name>Q9X7V3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6758</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35398">
        <property type="entry name" value="T35398"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630830.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031160.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6758"/>
    <dbReference type="GeneID" id="1102197"/>
    <dbReference type="KEGG" id="sco:SCO6758"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6867"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9X7V3"/>
    <dbReference type="OMA" id="VHIVYRV"/>
    <dbReference type="PhylomeDB" id="Q9X7V3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="34"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="27702" checksum="19DF418486F9BD4D" modified="1999-11-01" version="1">MPTVIADEVHIVYRVNGAKTGKGSATAALSRILKKGSDDAKRGVRKVHAVRGVSFTAYRGEAIGLIGSNGSGKSTLLRAIAGLLPAERGKVYTDGQPSLLGVNAALMNDLTGERNVILGGLAMGMSREQIKERYQEIVDFSGINEKGDFITLPMRTYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQTRSEERIRELKKQAGTIFLVSHNNKSIRDTCNRVLWLERGELRMDGPTDEVLKEYEKFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Y2</accession>
    <name>Q9X7Y2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="19">1.3.8.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ordered locus">SCO6787</name>
    </gene>
    <organism evidence="29">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(5Z)-tetradecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,5Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:84650"/>
            <dbReference type="ChEBI" id="CHEBI:87701"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:47449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(9Z)-octadecenoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E,9Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47300"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:77553"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:47301"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + hexadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H(+) + octanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-octenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>H(+) + oxidized [electron-transfer flavoprotein] + tetracosanoyl-CoA = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H(+) + oxidized [electron-transfer flavoprotein] + tetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a long-chain 2,3-saturated fatty acyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:17721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83721"/>
            <dbReference type="ChEBI" id="CHEBI:83727"/>
            <dbReference type="EC" id="1.3.8.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17722"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>decanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-decenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>docosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47228"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
            <dbReference type="ChEBI" id="CHEBI:74692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:47229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dodecanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>eicosanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 24">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17 24">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.8" evidence="19"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35427">
        <property type="entry name" value="T35427"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031182.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6787"/>
    <dbReference type="GeneID" id="1102226"/>
    <dbReference type="KEGG" id="sco:SCO6787"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6895"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_11"/>
    <dbReference type="InParanoid" id="Q9X7Y2"/>
    <dbReference type="OMA" id="QWEKDGI"/>
    <dbReference type="PhylomeDB" id="Q9X7Y2"/>
    <dbReference type="UniPathway" id="UPA00660"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain-acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01160">
        <property type="entry name" value="LCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034179">
        <property type="entry name" value="LCAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23 24" id="KW-0274">FAD</keyword>
    <keyword evidence="22 24" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="24" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="27">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="26">
        <location>
            <begin position="125"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="25">
        <location>
            <begin position="235"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00000392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00000733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00001236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00001337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00001483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00001486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00001547"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001740"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00012040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00014123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAB39720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="382" mass="42144" checksum="56C480C43643F40C" modified="1999-11-01" version="1">MTFRRDLYGPDHEAFRDTVRAFLAKEVAPHHQRWERNGVVDREVWYSAGRQGLLGPAVDQEYGGGGSDDFRYSAVLIEEFARAGASGLALSLHNDIVGPYLTRLATEEQKRRWLPGFVSGDIVTAIAMTEPGAGSDLQGIRTTATDRGDHYLLNGSKTFISNGILADLVVVVARTTPEGGSAGQSLLVVERGADGFERGRNLAKIGQQAQDTAELFFNDVHVPKENLLGEENRAFTYLMGNLAQERLAIAVGAAAATEEILDITTRYVKEREAFGRPLAKLQHVRFEIAEMATEAAVTRTFLDRCVTEHVAGRLDPVHASMAKWWATELQKRVVDRCLQLHGGYGYMSEYRVARAFLDGRIQTIYGGTTEIMKEIIGRSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X818</accession>
    <name>Q9X818_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative large membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2160</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35542">
        <property type="entry name" value="T35542"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626416.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028170.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2160"/>
    <dbReference type="GeneID" id="1097594"/>
    <dbReference type="KEGG" id="sco:SCO2160"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2196"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027141_0_0_11"/>
    <dbReference type="OMA" id="GLPTYGW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="516" mass="51305" checksum="59C96D45B7D833BF" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X839</accession>
    <name>CYC2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Germacradienol/geosmin synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>Germacradienol/germacrene D synthase</fullName>
                <ecNumber>4.2.3.22</ecNumber>
                <ecNumber>4.2.3.75</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Sesquiterpene cyclase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Sesquiterpene synthase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Geosmin synthase</fullName>
                <ecNumber>4.1.99.16</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="primary">cyc2</name>
        <name type="ordered locus">SCO6073</name>
        <name type="ORF">SC9B1.20</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1547" last="1551">
            <title>Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis.</title>
            <authorList>
                <person name="Cane D.E."/>
                <person name="Watt R.M."/>
            </authorList>
            <dbReference type="PubMed" id="12556563"/>
            <dbReference type="DOI" id="10.1073/pnas.0337625100"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-10</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>DOMAIN</scope>
        <scope>KINETIC PARAMETERS</scope>
        <scope>COFACTOR</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="1541" last="1546">
            <title>PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.</title>
            <authorList>
                <person name="Gust B."/>
                <person name="Challis G.L."/>
                <person name="Fowler K."/>
                <person name="Kieser T."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="12563033"/>
            <dbReference type="DOI" id="10.1073/pnas.0337542100"/>
        </citation>
        <scope>DOMAIN</scope>
        <scope>ROLE IN GEOSMIN BIOSYNTHESIS</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="J. Am. Chem. Soc." volume="126" first="2678" last="2679">
            <title>Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="He X."/>
                <person name="Cane D.E."/>
            </authorList>
            <dbReference type="PubMed" id="14995166"/>
            <dbReference type="DOI" id="10.1021/ja039929k"/>
        </citation>
        <scope>FUNCTION IN GERMACRENE D PRODUCTION</scope>
        <scope>REACTION STEREOCHEMISTRY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="J. Am. Chem. Soc." volume="128" first="8128" last="8129">
            <title>Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.</title>
            <authorList>
                <person name="Jiang J."/>
                <person name="He X."/>
                <person name="Cane D.E."/>
            </authorList>
            <dbReference type="PubMed" id="16787064"/>
            <dbReference type="DOI" id="10.1021/ja062669x"/>
        </citation>
        <scope>FUNCTION IN DIRECT GEOSMIN PRODUCTION</scope>
        <scope>COFACTOR</scope>
        <scope>REACTION MECHANISM</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5">Tow-domain protein where the N-terminal domain catalyzes the cyclization of farnesyl diphosphate (FPP) to a 85:15 mixture of the sesquiterpene alcohol germacradienol and the sesquiterpene hydrocarbon germacrene D. The C-terminal domain partially converts the germacradienol formed into geosmin, the characteristic odoriferous ('earthy aroma') constituent of Streptomyces species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46734"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="4.2.3.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone</text>
            <dbReference type="Rhea" id="RHEA:30371"/>
            <dbReference type="ChEBI" id="CHEBI:15347"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46702"/>
            <dbReference type="ChEBI" id="CHEBI:46734"/>
            <dbReference type="EC" id="4.1.99.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12016"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:49044"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="4.2.3.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2 5">Magnesium. Fe(2+) or Cu(2+) ions are very less efficient as cofactors.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">62 nM for FPP</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text>Secondary metabolite biosynthesis; geosmin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text>Sesquiterpene biosynthesis; germacradienol biosynthesis; germacradienol from farnesyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text>Sesquiterpene biosynthesis; germacrene D biosynthesis; germacrene D from farnesyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="2 3">Consists of 2 homologous sesquiterpene synthase domains. The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).</text>
    </comment>
    <comment type="miscellaneous">
        <text>The earthy odorant geosmin is also responsible for the 'off-flavor' of contaminated drinking water, wines, and other foodstuffs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">It is uncertain whether the initial Met is cleaved or not.</text>
    </comment>
    <comment type="online information" name="Protein Spotlight">
        <link uri="https://web.expasy.org/spotlight/back_issues/035"/>
        <text>The earth's perfume - Issue 35 of June 2003</text>
    </comment>
    <dbReference type="EC" id="4.2.3.22"/>
    <dbReference type="EC" id="4.2.3.75"/>
    <dbReference type="EC" id="4.1.99.16"/>
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        <property type="protein sequence ID" value="CAB41566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35865">
        <property type="entry name" value="T35865"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630182.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030632.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="PDB" id="5DW7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A=1-366"/>
    </dbReference>
    <dbReference type="PDB" id="5DZ2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.11 A"/>
        <property type="chains" value="A/B=1-338"/>
    </dbReference>
    <dbReference type="PDBsum" id="5DW7"/>
    <dbReference type="PDBsum" id="5DZ2"/>
    <dbReference type="AlphaFoldDB" id="Q9X839"/>
    <dbReference type="SMR" id="Q9X839"/>
    <dbReference type="STRING" id="100226.SCO6073"/>
    <dbReference type="GeneID" id="1101514"/>
    <dbReference type="KEGG" id="sco:SCO6073"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6175"/>
    <dbReference type="eggNOG" id="ENOG502Z881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372108_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X839"/>
    <dbReference type="OMA" id="RLPLFMP"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-14022"/>
    <dbReference type="BRENDA" id="4.1.99.16">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="BRENDA" id="4.2.3.22">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q9X839"/>
    <dbReference type="UniPathway" id="UPA00209"/>
    <dbReference type="UniPathway" id="UPA00283">
        <property type="reaction ID" value="UER00583"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00285">
        <property type="reaction ID" value="UER00584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034004">
        <property type="term" value="F:germacradienol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052577">
        <property type="term" value="F:germacrene-D synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="initiator methionine" description="Removed" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000247895" description="Germacradienol/geosmin synthase">
        <location>
            <begin position="2"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Germacradienol/germacrene D synthase">
        <location>
            <begin position="2"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Geosmin synthase">
        <location>
            <begin position="355"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DDXXD motif 1; degenerate">
        <location>
            <begin position="86"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DDXXD motif 2; degenerate">
        <location>
            <begin position="455"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="43"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="48"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="247"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="284"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="helix" evidence="7">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12556563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12563033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="14995166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16787064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5DW7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5DZ2"/>
        </source>
    </evidence>
    <sequence length="726" mass="81474" checksum="CB332AC7840EB81E" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X864</accession>
    <name>Q9X864_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative maturase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3508</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36091"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627708.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029044.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3508"/>
    <dbReference type="GeneID" id="1098944"/>
    <dbReference type="KEGG" id="sco:SCO3508"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3566"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785742_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X864"/>
    <dbReference type="PhylomeDB" id="Q9X864"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB41207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15791" checksum="99DCE05771DDF89E" modified="1999-11-01" version="1">MNTDELEHRRFDDLFSLVADPGFLLVAWDLVRGNKGASAAGVDGSTASSIALWVGVEKFLDMLRSQIKDRSFQPMPVRERMIPKAGGKLRRLGIATITDRVVQASLKLARFGEAAPGKRTGRKTGTAPRADFTPAIGCAFRYSPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8K6</accession>
    <name>R31B2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31 type B 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE2-2</name>
        <name type="ordered locus">SCO3427</name>
        <name type="ORF">SCE9.34c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36353">
        <property type="entry name" value="T36353"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627633.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975406.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8K6"/>
    <dbReference type="STRING" id="100226.SCO3427"/>
    <dbReference type="GeneID" id="1098864"/>
    <dbReference type="KEGG" id="sco:SCO3427"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3489"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_2_2_11"/>
    <dbReference type="InParanoid" id="Q9X8K6"/>
    <dbReference type="OMA" id="FKDMSND"/>
    <dbReference type="PhylomeDB" id="Q9X8K6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000173268" description="50S ribosomal protein L31 type B 2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <sequence length="84" mass="9781" checksum="0281CDFD60B8C1A0" modified="1999-11-01" version="1">MRKGIHPEYRPVVFRDRAADYAFLTRSTMTSERTVEWEDGRTYPVVDVEVSHVSHPFYTGTARVLDTAGRVERFERRYGKQDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8P9</accession>
    <name>Q9X8P9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36522">
        <property type="entry name" value="T36522"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975307.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3632"/>
    <dbReference type="GeneID" id="1099068"/>
    <dbReference type="KEGG" id="sco:SCO3632"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3691"/>
    <dbReference type="eggNOG" id="COG1510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120349_0_0_11"/>
    <dbReference type="OMA" id="TLAFFEF"/>
    <dbReference type="PhylomeDB" id="Q9X8P9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="17053" checksum="670639C43BA1CAC7" modified="1999-11-01" version="1">MSKFVEGFAAQLVEAGMQRMPARVFAALLASDSGSLTSAELGEGLRVSPAAVSGAVRYLSQQHMVSREREPGSRRERYRVHSNQWYEALTNREAILKRWENALRDGVTSLGADTPAGRRMAETLAFFEFVDEEIAAMMERWRVHREKTFGTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8R6</accession>
    <name>ALF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Fructose-bisphosphate aldolase</fullName>
            <shortName>FBP aldolase</shortName>
            <shortName>FBPA</shortName>
            <ecNumber>4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fructose-1,6-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">fba</name>
        <name type="ordered locus">SCO3649</name>
        <name type="ORF">SCH10.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36539">
        <property type="entry name" value="T36539"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627843.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029142.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8R6"/>
    <dbReference type="SMR" id="Q9X8R6"/>
    <dbReference type="STRING" id="100226.SCO3649"/>
    <dbReference type="PRIDE" id="Q9X8R6"/>
    <dbReference type="GeneID" id="1099085"/>
    <dbReference type="KEGG" id="sco:SCO3649"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3709"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X8R6"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="PhylomeDB" id="Q9X8R6"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000178743" description="Fructose-bisphosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="253"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="343" mass="36927" checksum="A1E2BE768028CE2C" modified="1999-11-01" version="1">MPIATPEVYNEMLDRAKAGKFAYPAINVTSSQTLHAALRGFAEAESDGIVQISTGGAEFLGGQHNKDMVTGAVALAEFAHIVAEKYDVTVALHTDHCPKDKLDGYVRPLIAVSEERVKAGRNPLFQSHMWDGSAETLADNLSIAQELLARARAARIILEVEITPTGGEEDGVSHEINDSLYTTVDDAVRTVEALGLGEKGRYLLAASFGNVHGVYKPGNVVLRPELLKELNEGIASKYGQPAGSKPFDFVFHGGSGSTAEEIATALENGVVKMNIDTDTQYAFTRPVVDHMFRNYDGVLKVDGEVGNKKTYDPRTWGKLAEAGMAARVVEACGHLRSAGQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8X8</accession>
    <name>Q9X8X8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3696</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36631">
        <property type="entry name" value="T36631"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627888.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975241.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3696"/>
    <dbReference type="GeneID" id="1099132"/>
    <dbReference type="KEGG" id="sco:SCO3696"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3755"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_11"/>
    <dbReference type="InParanoid" id="Q9X8X8"/>
    <dbReference type="OMA" id="CCPPLTE"/>
    <dbReference type="PhylomeDB" id="Q9X8X8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="122" mass="13211" checksum="5B37FFA7169F9332" modified="1999-11-01" version="1">MSNVKALPLLEPEAPDAAVVPCCPPLSERPLTAEEAERTARMFKALGDPVRLRLFSSVASHEGGEACVCDISDVGVSQPTVSHHLKKLKEAGLLTSERRGTWVYYRVEPSVLAAMGQLLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Z5</accession>
    <name>Q9X9Z5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1797</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB45289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36858">
        <property type="entry name" value="T36858"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626067.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977025.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1797"/>
    <dbReference type="GeneID" id="1097231"/>
    <dbReference type="KEGG" id="sco:SCO1797"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1818"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116732_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X9Z5"/>
    <dbReference type="OMA" id="AMPEFGM"/>
    <dbReference type="PhylomeDB" id="Q9X9Z5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="143" mass="14810" checksum="7F2C8F0CF63FF873" modified="1999-11-01" version="1">MNDIDAWVWWLVAAAALGIPLVVTAMPEFGMFAVGAVAAAVASGLGADLVVQVLVFVIVSVALIAVVRPIAARHRSQQPQLATGVDALKGRQAVVLERVDGAGGRIKLAGEIWSARALDTGRAFEPGEEVDVVEIDGATAVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA70</accession>
    <name>Q9XA70_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3807</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36488">
        <property type="entry name" value="T36488"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627996.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975129.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3807"/>
    <dbReference type="GeneID" id="1099243"/>
    <dbReference type="KEGG" id="sco:SCO3807"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3875"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_11"/>
    <dbReference type="InParanoid" id="Q9XA70"/>
    <dbReference type="OMA" id="KIHRFGF"/>
    <dbReference type="PhylomeDB" id="Q9XA70"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="28493" checksum="FC9C3EECA25450CF" modified="1999-11-01" version="1">MRASLIQIAVNEDETVEARRVRAAALVREQAGADLVVLPELWTTGAFAFEEFDAAAEPLRGPTYEAMAKAASDAGVWLHAGSVPERGPDGRLYNTSLVFSPAGDLTASYRKIHRFGFDKGEAVLMGAGREPVTVRLPDTTLGVATCYDLRFPELFRSLVDAGAEILVVPAGWPERRRAHWTLLARARAVENQAFVLACGTAGTHAGVPQAGHSIVVDPWGEVLAEAGADEEVLAVEFDPERVARTREQFPALKDRVLGLEPPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA83</accession>
    <name>Q9XA83_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0842</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36455">
        <property type="entry name" value="T36455"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625142.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027384.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0842"/>
    <dbReference type="GeneID" id="1096265"/>
    <dbReference type="KEGG" id="sco:SCO0842"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.834"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_2_11"/>
    <dbReference type="InParanoid" id="Q9XA83"/>
    <dbReference type="OMA" id="WQWSASS"/>
    <dbReference type="PhylomeDB" id="Q9XA83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB48919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="458" mass="50485" checksum="589600508E6A25B5" modified="1999-11-01" version="1">MATSVVLFTRDLRLHDHPPLRAALDRSDAVVPLFVRDRAVDAAGFAAPNRLALLADCLRDLDSGLRDRGGRLVVRSGDLVEEVCAVAGEAEADEVHLAADVSAHAHRREELLRSALSARGCRLHVHDAVTTVLAPGSVTPASSDHFAVFTPYFRRWSERAVREPLAAPRRVRVPDGVGSEPLPARGDLTGLSPGLPTGGERDARKRLTAWLRGGIADYADHHDDLAGDATSRLSPDLHLGALSPVELVHRARRAGGPGAEAFVRQLAWRDFHHQVLAARPHASAADYRTRHDRWRTGAAAEADAAAWRDGRTGYPVVDAAMRQLRHEGWMHNRGRLLVASFLTKTLYVDWRVGAWHFLELLVDGDVANNQLNWQWAAGTGTDTRPHRVLNPTTQARRFDPGGTYVRRWVPELAGLAGRSVHEPWRLARAARAAYDAYPDPIVDLSEGLDRFRRARGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA96</accession>
    <name>Q9XA96_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO0829</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36442">
        <property type="entry name" value="T36442"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027377.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0829"/>
    <dbReference type="CAZy" id="CBM12">
        <property type="family name" value="Carbohydrate-Binding Module Family 12"/>
    </dbReference>
    <dbReference type="MEROPS" id="S01.265"/>
    <dbReference type="GeneID" id="1096252"/>
    <dbReference type="KEGG" id="sco:SCO0829"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.821"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_2_1_11"/>
    <dbReference type="InParanoid" id="Q9XA96"/>
    <dbReference type="OMA" id="YSIIRAD"/>
    <dbReference type="PhylomeDB" id="Q9XA96"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177039" evidence="8">
        <location>
            <begin position="32"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="9">
        <location>
            <begin position="412"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB48906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="458" mass="46781" checksum="AFBB79E098D007FE" modified="1999-11-01" version="1">MVGRHAARSRRAALTALGALVLTALPSAASAAPPPVPGPRPAVARTPDAATAPARMLSAMERDLRLAPGQAAARLVNEAEAGTRAGMLRNTLGDRFAGAWVSGATSAELTVATTDAADTAAIEAQGAKAAVVGRNLAELRAVKEKLDAAAVRTRTRQTPVWYVDVKTNRVTVQATGASAAAAFVEAAGVPAADVGVRVSPDQPRVLEDLVGGDAYYIDDQARCSIGFSVTKDDQEGFATAGHCGDPGATTTGYNEADQGTFQASTFPGKDMAWVGVNSDWTATPDVKAEGGEKIQLAGSVEALVGASVCRSGSTTGWHCGTIQQHDTSVTYPEGTVDGLTETTVCAEPGDSGGPFVSGVQAQGTTSGGSGDCTNGGTTFYQPVNPLLSDFGLTLKTTSAATQTPAPQDNAAADAWTAGRVYEVGTTVSYDGVRYRCLQSHQAQGVGSPASVPALWQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAB2</accession>
    <name>Q9XAB2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36426">
        <property type="entry name" value="T36426"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625113.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027370.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0813"/>
    <dbReference type="GeneID" id="1096236"/>
    <dbReference type="KEGG" id="sco:SCO0813"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.805"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024866_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAB2"/>
    <dbReference type="OMA" id="KHGLVTW"/>
    <dbReference type="PhylomeDB" id="Q9XAB2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013454">
        <property type="entry name" value="Bifunc_RhaD/ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02632">
        <property type="entry name" value="RhaD_aldol-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB48890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="679" mass="71668" checksum="3826C2684B73BBA4" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="148" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAR0</accession>
    <name>NUOG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>NADH-quinone oxidoreductase subunit G</fullName>
            <ecNumber>7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>NADH dehydrogenase I subunit G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>NDH-1 subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nuoG</name>
        <name type="ordered locus">SCO4568</name>
        <name type="ORF">SCD16A.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34618">
        <property type="entry name" value="T34618"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628730.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029735.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAR0"/>
    <dbReference type="SMR" id="Q9XAR0"/>
    <dbReference type="STRING" id="100226.SCO4568"/>
    <dbReference type="GeneID" id="1100008"/>
    <dbReference type="KEGG" id="sco:SCO4568"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4640"/>
    <dbReference type="eggNOG" id="COG1034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAR0"/>
    <dbReference type="OMA" id="NVYFGRV"/>
    <dbReference type="PhylomeDB" id="Q9XAR0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <feature type="chain" id="PRO_0000118563" description="NADH-quinone oxidoreductase subunit G">
        <location>
            <begin position="1"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="843" mass="88862" checksum="318D67C27AAA5193" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-06-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5B9</accession>
    <name>Q9Z5B9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34837">
        <property type="entry name" value="T34837"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630286.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030719.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6183"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="GeneID" id="1101624"/>
    <dbReference type="KEGG" id="sco:SCO6183"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6293"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_3_11"/>
    <dbReference type="InParanoid" id="Q9Z5B9"/>
    <dbReference type="OMA" id="VLTSFHQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008713">
        <property type="term" value="F:ADP-heptose-lipopolysaccharide heptosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB36591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="34441" checksum="57F0585E2792EC1B" modified="1999-05-01" version="1">MKALVTRLDSFGDVLLAGPAVRAVAARADHVTMVCGSRGAPAARLLPGIDEVLVWEAPWGGFEPPDVSRPDIDALVERIDADTALILTSFHQSPLPTALVLRLAGVRYIAADSEDYPGSLLDLRHHRAPHAHEAEAALDLAEAAGFPAPDDGRLRVRTPPRADALTGPGPYVVLHPGASVPARAWSPGRAAEAVRELAAAGHRVLVTGGPDERGLTAHVAGAHGTDLGGRTDAPTLAGVLAGAAAVVTGNTAPAHLAAAVGTPVVSLFAPVVPAERWRPYGVPHVLLGDQDAPCADSRARDCPVPGHPCLDTVTATDVAAAVEKLIAVTQPMGET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBA5</accession>
    <name>MURG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">SCO2084</name>
        <name type="ORF">SC4A10.17c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kuennen R.A."/>
                <person name="Stadelmaier B.T."/>
                <person name="McCormick J.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="U10879">
        <property type="protein sequence ID" value="AAD10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34954">
        <property type="entry name" value="T34954"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626343.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976731.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBA5"/>
    <dbReference type="SMR" id="Q9ZBA5"/>
    <dbReference type="STRING" id="100226.SCO2084"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q9ZBA5"/>
    <dbReference type="GeneID" id="1097518"/>
    <dbReference type="KEGG" id="sco:SCO2084"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2117"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBA5"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="PhylomeDB" id="Q9ZBA5"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000109220" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="364" mass="38842" checksum="D600C5F94E9202E2" modified="1999-05-01" version="1">MHVVLAGGGTAGHIEPALALADALRRQDPTVGITALGTERGLETRLVPERGYELALIPAVPLPRKPTPELITVPGRLRGTIKATEQILERTKADAVAGFGGYVALPAYLAAKRLGVPIVVHEANARPGLANKIGSRYAAQVAVSTPDSKLRNSRYIGIPLRRSIATLDRAAARPEARAMFGLDPNLPTLLVTGGSQGARRLNEVIQQVAPWLQQAGIQILHAVGPKNELPQVHQMPGMPPYIPVSYLDRMDLAYAAADMMLCRAGAMTVAELSAVGLPAAYVPLPIGNGEQRLNAQPVVKAGGGLLVDDAELTPEWLQQNVLPVLADPHRLYEMSRAAAEFGRRDADDLLVGMVYEAIAARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN3</accession>
    <name>Q9ZBN3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6176</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35483">
        <property type="entry name" value="T35483"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630280.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6176"/>
    <dbReference type="GeneID" id="1101617"/>
    <dbReference type="KEGG" id="sco:SCO6176"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6286"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060500_5_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBN3"/>
    <dbReference type="OMA" id="YNVHSCI"/>
    <dbReference type="PhylomeDB" id="Q9ZBN3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="276" mass="29702" checksum="67FEC7378D31B980" modified="1999-05-01" version="1">MTLAVTAQPALAADRGHSVPLRIATYNIHAGAGSDGVFDLDRQAAALRALDADVIGLQEVDVHWGARSQGLDVAGELARRLGMRVSFAPIYSLDPVTAGEPRREYGVAVLSRFPVRSATNHEITRLSTQDENPLPAPAPGFGEVTLKVRGVPVQVFVTHLDYRADPAVRRAQVADTRRIMARERAELPGAHQFLLGDFNAEPAAPELAPLWKELSDAGAGTPATYPAQAPVKRIDYVTAGKDVRIRRTAVPEEPAASDHRPVVADVSLPRRTPGRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ7</accession>
    <name>RNC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease 3</fullName>
            <ecNumber>3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Antibiotic biosynthesis protein B</fullName>
            <shortName>AbsB</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Ribonuclease III</fullName>
            <shortName>RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rnc</name>
        <name type="synonym">absB</name>
        <name type="ordered locus">SCO5572</name>
        <name type="ORF">SC7A1.16</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="6142" last="6151">
            <title>A Streptomyces coelicolor antibiotic regulatory gene, absB, encodes an RNase III homolog.</title>
            <authorList>
                <person name="Price B."/>
                <person name="Adamidis T."/>
                <person name="Kong R."/>
                <person name="Champness W."/>
            </authorList>
            <dbReference type="PubMed" id="10498729"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION IN PROCESSING OF RRNA</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF LEU-172</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="58" first="1276" last="1287">
            <title>Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Huang J."/>
                <person name="Shi J."/>
                <person name="Molle V."/>
                <person name="Sohlberg B."/>
                <person name="Weaver D."/>
                <person name="Bibb M.J."/>
                <person name="Karoonuthaisiri N."/>
                <person name="Lih C.J."/>
                <person name="Kao C.M."/>
                <person name="Buttner M.J."/>
                <person name="Cohen S.N."/>
            </authorList>
        </citation>
        <scope>ROLE IN GLOBAL GENE REGULATION</scope>
        <scope>MUTAGENESIS OF LEU-172</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="J. Bacteriol." volume="193" first="4371" last="4379">
            <title>RNase III-dependent expression of the rpsO-pnp operon of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Gatewood M.L."/>
                <person name="Bralley P."/>
                <person name="Jones G.H."/>
            </authorList>
            <dbReference type="PubMed" id="21742867"/>
            <dbReference type="DOI" id="10.1128/JB.00452-11"/>
        </citation>
        <scope>FUNCTION AS AN ENDORIBONUCLEASE</scope>
        <scope>FUNCTION IN PROCESSING OF MRNA</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. May modulate key aspects of gene expression as its absence has extensive effects on the abundance of about 200 different transcripts. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 6">Not essential. Deficient in endogenous antibiotic synthesis, able to form a sporulating aerial mycelium. Accumulates a 30S rRNA precursor transcript. Leads to increased expression of pnp due to increased transcript levels.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAA22415" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22415.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35656">
        <property type="entry name" value="T35656"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629707.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973423.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBQ7"/>
    <dbReference type="SMR" id="Q9ZBQ7"/>
    <dbReference type="STRING" id="100226.SCO5572"/>
    <dbReference type="GeneID" id="1101013"/>
    <dbReference type="KEGG" id="sco:SCO5572"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5661"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ7"/>
    <dbReference type="BRENDA" id="3.1.26.3">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000180440" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="In strain C120; loss of endogenous antibiotic synthesis, decrease in transcript abundance of genes involved in secondary metabolism." evidence="4 5">
        <original>L</original>
        <variation>P</variation>
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="10498729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16313616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21742867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="276" mass="29141" checksum="D0C69BEABF62313C" modified="2012-04-18" version="2">MRGTVSVPKKAEDAKADPPAKKKADTQASSHTLLEGRLGYQLESALLVRALTHRSYAYENGGLPTNERLEFLGDSVLGLVVTDTLYRTHPDLPEGQLAKLRAAVVNSRALAEVGRGLELGSFIRLGRGEEGTGGRDKASILADTLEAVIGAVYLDQGLDAASELVHRLFDPLIEKSSNLGAGLDWKTSLQELTATEGLGVPEYLVTETGPDHEKTFTAAARVGGVSYGTGTGRSKKEAEQQAAESAWRSIRAAADERAKATADAVDADPDEASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBX6</accession>
    <name>Q9ZBX6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3956</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36062">
        <property type="entry name" value="T36062"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628140.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974987.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3956"/>
    <dbReference type="TCDB" id="3.A.1.146.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099392"/>
    <dbReference type="KEGG" id="sco:SCO3956"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4028"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBX6"/>
    <dbReference type="OMA" id="VVHMARM"/>
    <dbReference type="PhylomeDB" id="Q9ZBX6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA22228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="34344" checksum="43C4E0A4E65E1FAD" modified="1999-05-01" version="1">MIATESLSKRFPRVTALDRLSVDVGPGVTGLVGANGAGKSTLIKILLGLSPATEGRAEVLGLDVATKGADIRERVGYMPEHDCLPPDVSATEFVVHMARMSGLPPTAARERTADTLRHVGLYEERYRPIGGYSTGMKQRVKLAQALVHDPQLVFLDEPTNGLDPVGRDEMLGLIRRIHTDFGISVLVTSHLLGELERTCDHVVVVDGGKLLRSSSTTDFTQTTTTLAIEVTDTDEHPDGTRAVREALDARGVSVQDGSGLPGAGRVLLLTSAGEETYDLVRDVIADLGLGLVRMEQRRHHISEVFTDSDAARKEAVGHGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O50533</accession>
    <name>CPFC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="1">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpfC</name>
        <name type="synonym">hemH</name>
        <name type="ordered locus">SCO5859</name>
        <name type="ORF">SC9B10.26</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35895">
        <property type="entry name" value="T35895"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629982.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973161.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50533"/>
    <dbReference type="SMR" id="O50533"/>
    <dbReference type="STRING" id="100226.SCO5859"/>
    <dbReference type="GeneID" id="1101301"/>
    <dbReference type="KEGG" id="sco:SCO5859"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5958"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_2_0_11"/>
    <dbReference type="InParanoid" id="O50533"/>
    <dbReference type="OMA" id="WLEPDIC"/>
    <dbReference type="PhylomeDB" id="O50533"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000175210" description="Coproporphyrin III ferrochelatase">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="375" mass="40622" checksum="650547197DF326FD" modified="1998-06-01" version="1">MPDVLDASPYDALLLLSFGGPEGPDDVVPFLENVTRGRGIPKERLKEVGQHYFLFGGVSPINDQNRALLDALRKDFAEHGLDLPVYWGNRNWAPYLTDTLREMVGDGRRRILVLATSAYASYSGCRQYRENLADALAALESEGLELPKIDKLRHYFNHPGFVEPMVDGVVRSLAELPAEVRDGAHIAFCTHSIPTSAADGSGPVEEHGDGGAYVRQHLDVARLIADAVRERTGVDHPWQLVYQSRSGAPHIPWLEPDICDHLEERQAAGVPAVVMAPIGFVSDHMEVLYDLDTEATAKAEELGLPVRRSATVGADPRFAAAVRDLVLERAGDERGQEVTPCALGTLGASHNLCPVGCCPARAPRPAAAGADSPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O69915</accession>
    <name>O69915_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6383</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34877">
        <property type="entry name" value="T34877"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630474.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030880.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6383"/>
    <dbReference type="GeneID" id="1101824"/>
    <dbReference type="KEGG" id="sco:SCO6383"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6491"/>
    <dbReference type="eggNOG" id="ENOG50331A3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099050_0_0_11"/>
    <dbReference type="OMA" id="AFRCRAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="24457" checksum="8B41DAF7717A8B99" modified="1998-08-01" version="1">MLAKKRPVRPAARLLRREWGPVWAVVRAELADRRGRAIPLTLSALCLIVLFQVAQHQRSPYWGYGLVQDVGFVRAADPWWLALARTPLSLFVPAADLPVWGALAQVLVVFGIAEIALGRRRTLLIAYICTLAGVVYARIGVAVGPGGVLGLPAGDAQVVDTGPSGAVAGLAVYLCLRFRAWFTGALVGMGMFVEAIAKPNLAGREHLVAIAVALAMSAFSTLRRRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O86716</accession>
    <name>O86716_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nitrate reductase beta chain NarH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6534</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35226">
        <property type="entry name" value="T35226"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630615.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030994.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6534"/>
    <dbReference type="GeneID" id="1101973"/>
    <dbReference type="KEGG" id="sco:SCO6534"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6637"/>
    <dbReference type="eggNOG" id="COG1140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_11"/>
    <dbReference type="InParanoid" id="O86716"/>
    <dbReference type="OMA" id="VYFNWQT"/>
    <dbReference type="PhylomeDB" id="O86716"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="531" mass="59739" checksum="7657FFBAECCF3274" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O86770</accession>
    <name>RRF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">SCO5627</name>
        <name type="ORF">SC6A9.40c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35471">
        <property type="entry name" value="T35471"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629761.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973383.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86770"/>
    <dbReference type="SMR" id="O86770"/>
    <dbReference type="STRING" id="100226.SCO5627"/>
    <dbReference type="GeneID" id="1101068"/>
    <dbReference type="KEGG" id="sco:SCO5627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5716"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_11"/>
    <dbReference type="InParanoid" id="O86770"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="PhylomeDB" id="O86770"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167550" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="185" mass="20787" checksum="0B0421294C466F05" modified="1998-11-01" version="1">MIEETLLEAEEKMEKAVVVAKEDFAAIRTGRAHPAMFNKIVAEYYGAPTPINQLASFSVPEPRMAVVTPFDKTALRNIEQAIRDSDLGVNPSNDGNIIRVTFPELTEERRREYIKVAKAKGEDAKVSIRSVRRKAKDSIDKMVKDGEVGEDEGRRAEKELDDTTAKYVAQVDELLKHKEAELLEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O86781</accession>
    <name>GLMS_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="1">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmS</name>
        <name type="ordered locus">SCO4740</name>
        <name type="ORF">SC6G4.18</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35569">
        <property type="entry name" value="T35569"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628898.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974233.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86781"/>
    <dbReference type="SMR" id="O86781"/>
    <dbReference type="STRING" id="100226.SCO4740"/>
    <dbReference type="GeneID" id="1100181"/>
    <dbReference type="KEGG" id="sco:SCO4740"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4812"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_11"/>
    <dbReference type="InParanoid" id="O86781"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="PhylomeDB" id="O86781"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000135389" description="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]">
        <location>
            <begin position="2"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 1" evidence="1">
        <location>
            <begin position="287"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 2" evidence="1">
        <location>
            <begin position="460"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="1">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <sequence length="615" mass="65561" checksum="72983AB15CA53E7F" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O86806</accession>
    <name>O86806_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5746</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35679">
        <property type="entry name" value="T35679"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629871.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030432.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5746"/>
    <dbReference type="GeneID" id="1101188"/>
    <dbReference type="KEGG" id="sco:SCO5746"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5835"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255376_0_0_11"/>
    <dbReference type="InParanoid" id="O86806"/>
    <dbReference type="OMA" id="YQQYVVR"/>
    <dbReference type="PhylomeDB" id="O86806"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="24160" checksum="CAEB7D9DDE7912C2" modified="1998-11-01" version="1">MGTAAMLRAAGVGVGDEVVVPAFGNVEVAEAVALAGALPVFADIDPDTYCLDASLVEAALTPRTAAVVVVHRFGRPADMGSLHRIGERHGLLVLERGESEAPYDEIARRRQRAAYLDGKLRGVRTPDGGDGHTYQQYVVRVPGNGRPDRDAFARAVRGRGVECRVPVRTPVHRMPGFRRCVSLPETERAVDETLALPVEAALTKRDMQRIVSACNALGGLLQPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O86818</accession>
    <name>O86818_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5758</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA19859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35691">
        <property type="entry name" value="T35691"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629883.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973266.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5758"/>
    <dbReference type="GeneID" id="1101200"/>
    <dbReference type="KEGG" id="sco:SCO5758"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5847"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_2_11"/>
    <dbReference type="InParanoid" id="O86818"/>
    <dbReference type="OMA" id="QIWRGRI"/>
    <dbReference type="PhylomeDB" id="O86818"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13745" checksum="2DA86A0ABE27D2B8" modified="1998-11-01" version="1">MVEEAEAGTDRLFQALADLTRRDILRRCVRDDLSVSRLAEAYPMSFAAVQKHVAVLERAGLVVKERCGREQLVRTDPDALGRARRALDELEAAWRGRVERMSGLLAEAPEAGSAARQPTEGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O86831</accession>
    <name>O86831_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ordered locus">SCO5668</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35802">
        <property type="entry name" value="T35802"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629797.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973357.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5668"/>
    <dbReference type="GeneID" id="1101107"/>
    <dbReference type="KEGG" id="sco:SCO5668"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5754"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_11"/>
    <dbReference type="InParanoid" id="O86831"/>
    <dbReference type="OMA" id="ARFMGDH"/>
    <dbReference type="PhylomeDB" id="O86831"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA20221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="397" mass="42352" checksum="11D6EE922D9203F9" modified="1998-11-01" version="1">MTTNPTKNQTAAKDGGGDVRLAGISKTYGSFTAVHPLDLTVPQGSFFALLGASGCGKTTTLRMIAGLEEPSGGTVHLGDQDVTALPPYKRPVNTVFQSYALFPHLDIYENVAFGLRRRGIKSVKKQVGEMLDLVQLGEQARKKPHQLSGGQQQRVAVARALINHPKVLLLDEPLGALDLKLRRQMQLELKRIQTEVGITFVHVTHDQEEAMTMADQVAVMNAGRVEQLGAPADLYENPRTTFVANFLGTSNLIEAEVDTRSGDDVVVKAAGDKLVLPGARCSAPAKTGGKVLVGVRPEKISLTHADDAGSIPEGRNRITGRIGSTSFIGVSTQYVVDCAACPEFEVYAQNIDRDPRLTPGAEVVLHWNPAHTFGLDADQSVLAGTMGDAGVAEGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O87853</accession>
    <name>O87853_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6598</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35786">
        <property type="entry name" value="T35786"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630677.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972380.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6598"/>
    <dbReference type="GeneID" id="1102037"/>
    <dbReference type="KEGG" id="sco:SCO6598"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6705"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="O87853"/>
    <dbReference type="OMA" id="EINYFPN"/>
    <dbReference type="PhylomeDB" id="O87853"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="346" mass="36869" checksum="C20C31C4FF2DB032" modified="1998-11-01" version="1">MSRQAPTLEDVAREAGVSRATVSRVVNGVRNVDPAIQDLVRRAIERTGYAPNQAARQLVTRRTTTVALVVSGAGDATDTEQNAFATRVFADPFFGRVVGGVVGHLRPRRMHPVLMFAETPEARQEVVAYLRQGGADGALVVSTHPDDPLPALLAGAGLPAVLFARPGRPVPLSYVDLAHREGGRLAAEHLLERGCRRIATVAGPLAVAASQERLAGFRDTLARHGHPYVPVAEGGFTVDSGMAAMTSLLAEHPDTDGVFTANDLMAQGAVQVLRDHGRRVPQDVAVVGFDDSSVAVTCRPRLTTVRQPVEEMAATMARLLDDHIKGARGEPTSVVFDPELVVRESA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O88022</accession>
    <name>MMPLC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative membrane protein SCO6666</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO6666</name>
        <name type="ORF">SC5A7.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35165">
        <property type="entry name" value="T35165"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630741.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031089.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O88022"/>
    <dbReference type="SMR" id="O88022"/>
    <dbReference type="STRING" id="100226.SCO6666"/>
    <dbReference type="GeneID" id="1102105"/>
    <dbReference type="KEGG" id="sco:SCO6666"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6772"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="InParanoid" id="O88022"/>
    <dbReference type="OMA" id="KDGIAHS"/>
    <dbReference type="PhylomeDB" id="O88022"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000103583" description="Putative membrane protein SCO6666">
        <location>
            <begin position="1"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="705" mass="73118" checksum="B1935ACE0F75390E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O88030</accession>
    <name>O88030_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6674</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35173">
        <property type="entry name" value="T35173"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630749.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972321.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6674"/>
    <dbReference type="GeneID" id="1102113"/>
    <dbReference type="KEGG" id="sco:SCO6674"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6780"/>
    <dbReference type="eggNOG" id="ENOG5032N5Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180129_0_0_11"/>
    <dbReference type="OMA" id="FRLLHAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8434" checksum="36303E7995EB47CF" modified="1998-11-01" version="1">MTTAVLTDRERTAVQAYLRLLHTVRAGFDTGTGPGDSPRPPVVPPSVLAEAEQALRAAGLTGNEEAFFRLLRDWCPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O88056</accession>
    <name>O88056_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1596</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36831">
        <property type="entry name" value="T36831"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625872.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027872.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1596"/>
    <dbReference type="GeneID" id="1097027"/>
    <dbReference type="KEGG" id="sco:SCO1596"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1608"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_11"/>
    <dbReference type="InParanoid" id="O88056"/>
    <dbReference type="OMA" id="TRFWRGS"/>
    <dbReference type="PhylomeDB" id="O88056"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="156"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="41020" checksum="4491A19EE71442F3" modified="1998-11-01" version="1">MSVGTSSAPGARQVPRPLAPRTSGDPADLGIDPDQLPDGLVVADEHGRVVCFNAAAVRITATPAAEALGQLLESALPLEDLEGRRWWQLTDPYGGLAIRVRQPERNLLLPGGREVLVTARYVRAERLGPVHRVVVTLRDTEARRRTERSHAELIATVAHELRSPLTSVKGFTATLLAKWERFTDDQKRLMLETVDADADRVTRLIAELLDISRIDSGRLEVRRQPVDIGAAVGRHIQAYVASGLEADRFLLRLAQPLPDLWADPDKVDQVLSNLLENAVRHGEGTVTIDVTPTASPREGEDTGTSVTVSDEGAGIPEESMNRVFTRFWRGSKRGGTGLGLYIVKGIVEAHGGTITVGRAPGGGAEFRFTLPVAAPAYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKL3</accession>
    <name>Q7AKL3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteinase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3540</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627738.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3540"/>
    <dbReference type="ESTHER" id="strco-SLPD">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1098976"/>
    <dbReference type="KEGG" id="sco:SCO3540"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3595"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="InParanoid" id="Q7AKL3"/>
    <dbReference type="OMA" id="LNCAYWP"/>
    <dbReference type="PhylomeDB" id="Q7AKL3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176020" evidence="1">
        <location>
            <begin position="36"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="123"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="539" mass="57034" checksum="3AC0689E01BA2C4A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-06-02" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJR8</accession>
    <name>Q8CJR8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO5289</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAD55347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35640">
        <property type="entry name" value="T35640"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733660.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030155.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5289"/>
    <dbReference type="GeneID" id="1100730"/>
    <dbReference type="KEGG" id="sco:SCO5289"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5375"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_3_0_11"/>
    <dbReference type="InParanoid" id="Q8CJR8"/>
    <dbReference type="OMA" id="TVMRRHS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="367"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="444"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="711"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="922"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="959"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAD55347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="979" mass="102484" checksum="97F49A3DD3130193" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX5</accession>
    <name>Q8CJX5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3150</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733594.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028795.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CJX5"/>
    <dbReference type="STRING" id="100226.SCO3150"/>
    <dbReference type="GeneID" id="1098584"/>
    <dbReference type="KEGG" id="sco:SCO3150"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3211"/>
    <dbReference type="eggNOG" id="COG3583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036884_1_1_11"/>
    <dbReference type="InParanoid" id="Q8CJX5"/>
    <dbReference type="OMA" id="ASPWPHC"/>
    <dbReference type="PhylomeDB" id="Q8CJX5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="458" mass="49599" checksum="95AB6B5BFF6944AF" modified="2003-03-01" version="1">MSRTQFEPAETYTAYTAYDEAYEAHEAYEAHEAYEAHETYERPAPYDLHSAPTLPYGGTYPSAPPPVHEPTVPALPRQSDGRAERRRRARGAGRADASLRRLVPRALVVAFLAGGTTAFVAKDKAVELTVDGSPRTLHTFADDVSELLAEEGVQVGAHDVIAPAPGTPLTSGEDVTVHHGRPVLLTLDGHRRQVWTTAGTVAGALRQLGVRTQGAYLSTGPSRRIGREGLALVVRTERVVTVMADGRTRTVRTNAATVGEVVEEAGITLRGEDTTSVPATGFPRDGQTVTVLRITGSQEVREDPIPFDERRAEDASLFRGTEVVQEAGRPGLRRTTYALRTVNGVRQKPRRLRTEVVREPSPRIVRVGTRPRPASVHGADHLNWQGLAACESGGRADAVDPSGTYGGLYQFDSATWHGLGGEGRPEDASAAEQTYRAQKLYVRSGADAWPHCGARLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX7</accession>
    <name>Q8CJX7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3092</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733592.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3092"/>
    <dbReference type="GeneID" id="1098526"/>
    <dbReference type="KEGG" id="sco:SCO3092"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3154"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_11"/>
    <dbReference type="InParanoid" id="Q8CJX7"/>
    <dbReference type="OMA" id="VDPRSYM"/>
    <dbReference type="PhylomeDB" id="Q8CJX7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="446" mass="48470" checksum="4E0D256CA1A513FB" modified="2003-03-01" version="1">MRYGEATVTVVDPRSYMTYQPFLPEAAAGSISPRHVVVPLRRVLPKAEVLTGRVTTIDQDRKVATVAPLVGEAYELPFDYLVIAMGAVSRTFPIPGLAEQGIGMKGIEESIGLRNHVLEQLDKADSTTDEEIRRKALTFVFVGGGFAGAETIGEVEDMARDAAKYYNNVSREDMRFILVDAADKILPEVGPKLGQYGKEHLEGRGVEVYLSTSMDSCVDGHVVLKNGLEVDSNTIVWTAGVKPNPALARFGLPLGPRGHVDTQATLQVQGTDYIWAAGDNAQVPDLVGRKAGNENAWCPPNAQHALRQAKVLGDNVISGMRGFPQKPYSHANKGAVAGLGLHKGVAMIVMGKMKIKLKGRLAWYMHRGYHGMAMPTFNRKIRVFADWTLGMFLKREVVSLGAMETPREEFYEAAKPAPKPAAAKAADQGDQSEKAAKQEKTEAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA3</accession>
    <name>Q93JA3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDE_N_bis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7493</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031702.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7493"/>
    <dbReference type="GeneID" id="1102931"/>
    <dbReference type="KEGG" id="sco:SCO7493"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7605"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019216_1_0_11"/>
    <dbReference type="InParanoid" id="Q93JA3"/>
    <dbReference type="OMA" id="AAYNPMS"/>
    <dbReference type="PhylomeDB" id="Q93JA3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="2">
        <location>
            <begin position="11"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="645" mass="69857" checksum="24DD80D4E871C99F" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK9</accession>
    <name>Q93JK9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629137.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029986.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4985"/>
    <dbReference type="GeneID" id="1100426"/>
    <dbReference type="KEGG" id="sco:SCO4985"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5066"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085086_0_0_11"/>
    <dbReference type="OMA" id="INYAQQT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176586" evidence="1">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="284" mass="29283" checksum="8BD06F240E90007E" modified="2001-12-01" version="1">MNKPLLAALATLAVTGVGVAPAAASPAAPAASASPAAPAVRAVSFAGTVALSNCSGSVVRLPASEDDDPALVMSNGHCLETGFPAAGEVVVDQPSSRTFGLLNASGTRVGTLRAGKIAYATMTDTDVSLYQLTSTYAQIRGSYGISPLTLDDTRPTAGTAITVVSGYWKRTYACNVDGFAYRLKEGEWTWKDSVRYTSACRTIGGTSGSPVVDNATGKVVAVNNTGNEDGGRCTDNNPCEVAEDGTVTVREGINYGQQTYRIPACFALDNKLDLSRSGCALPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACP8</accession>
    <name>Q9ACP8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.270</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639880.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039572.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095353"/>
    <dbReference type="KEGG" id="sco:SCP1.270"/>
    <dbReference type="HOGENOM" id="CLU_2358391_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9ACP8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="96" mass="10178" checksum="1A6EE60C3F839D09" modified="2001-06-01" version="1">MGGRDPVSDRYAGVVEHSVYVPPAARGRDVASTLLKALAGSTGSTERTGIWTIQSGIFPENTASLAVHQQAGFRSRARRCVQRVTCPTARGPLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADE2</accession>
    <name>Q9ADE2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5065</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629216.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030031.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5065"/>
    <dbReference type="GeneID" id="1100506"/>
    <dbReference type="KEGG" id="sco:SCO5065"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5144"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="InParanoid" id="Q9ADE2"/>
    <dbReference type="OMA" id="WPFERAQ"/>
    <dbReference type="PhylomeDB" id="Q9ADE2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="871"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC37453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="943" mass="99436" checksum="84C0514A58DE6D89" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADH0</accession>
    <name>Q9ADH0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6093</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030650.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6093"/>
    <dbReference type="GeneID" id="1101534"/>
    <dbReference type="KEGG" id="sco:SCO6093"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6196"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056929_3_0_11"/>
    <dbReference type="InParanoid" id="Q9ADH0"/>
    <dbReference type="OMA" id="WCAVRPA"/>
    <dbReference type="PhylomeDB" id="Q9ADH0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="26152" checksum="D16B53A5D82804D9" modified="2001-06-01" version="1">MSAPGRPVLLVVAHGSRDPRHAATVHALVRRVRALRPDVRVETGFLDFNVPSVPGVLESLETEGVRDVVALPLLLTRAFHAKADIPAVLAAAPPRLRIRQAEVLGPSPLLLSALERRLYEAGLTPADKSSTGVVLASAGSSDPEAIAVIAEIAREWRHTGWCAVRPAFASASLPRTEDAVRQLRELGCARVAVAPYVLAPGFLPDRIARGAAGADVLADVLGPAPEVARVLLERYDAARMPVALAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWD8</accession>
    <name>Q9EWD8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4869</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629023.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029916.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4869"/>
    <dbReference type="GeneID" id="1100310"/>
    <dbReference type="KEGG" id="sco:SCO4869"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4948"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_11"/>
    <dbReference type="InParanoid" id="Q9EWD8"/>
    <dbReference type="OMA" id="IAQKEWV"/>
    <dbReference type="PhylomeDB" id="Q9EWD8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="14"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC17657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="534" mass="58203" checksum="E74C85E36AC562FC" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWH8</accession>
    <name>Q9EWH8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2996</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC18733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627219.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028704.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2996"/>
    <dbReference type="GeneID" id="1098429"/>
    <dbReference type="KEGG" id="sco:SCO2996"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3055"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9EWH8"/>
    <dbReference type="OMA" id="RMDGPAK"/>
    <dbReference type="PhylomeDB" id="Q9EWH8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="33"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC18733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="288" mass="30722" checksum="8F971024FA10653B" modified="2001-03-01" version="1">MPTVVVDGVDIVYRVNGTGAGRGTATAALNRILRRGKTEKAAGVRRVHAVKKVSFVAYRGEAIGLIGTNGSGKSTLLKAVAGLLPVEHGRIYTDGQPSLLGVNAALMNDLTGERNVYLGGLAMGMSRAQVKERYQEIVDFSGINEKGDFITLPMRTYSSGMAARLRFSIAAAKDHDVLLVDEALATGDRSFQKRSEQRIRELRKHAGTVFLVSHSNKSIRDTCDRVLWLERGELRVDGPTEEVLKEYEKFTAGPGPAAKPKPQAKAAPAPAPASAPAPAPAPKAPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWM0</accession>
    <name>Q9EWM0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631802.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031896.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7769"/>
    <dbReference type="GeneID" id="1103206"/>
    <dbReference type="KEGG" id="sco:SCO7769"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7886"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="InParanoid" id="Q9EWM0"/>
    <dbReference type="OMA" id="SECATHT"/>
    <dbReference type="PhylomeDB" id="Q9EWM0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="29998" checksum="0FC99F1E97D500D9" modified="2001-03-01" version="1">MPGVLVTGGTGKTGKVLVQVLRNAGVQARVASRNPAAADPDPIRFDWNDPTTYGPALDGMDRVFLLPPVESVDPLPLVEPFLRRAQRAGVQRLVMLGSAIVLPNAPSAVEMAAQVQAQPGGVVLRASGFMQNFLRPHPLAEHIHRLGEIRTAAGDGRLGWVDARDIAASAAALLADLEVDARSDYLITGPHGMSYPQAAQIITAQTGRRVRVERITEEEQAAAHRASGMPPAFADALAAVERGIKEGREDQVSTAVLELTGRPPRTFAEFVSDHAYEWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWN9</accession>
    <name>Q9EWN9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7688</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971452.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7688"/>
    <dbReference type="GeneID" id="1103126"/>
    <dbReference type="KEGG" id="sco:SCO7688"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7809"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088151_0_0_11"/>
    <dbReference type="OMA" id="AMNMIGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="41"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="242" mass="26433" checksum="CADAEA1EA08B7D5C" modified="2001-03-01" version="1">MIDYYSTSAEFYELVATRHTASSGPPLTRVLTGLDVTHGPVLEIGAGTGRVTEVVAAALPEAEILAAEPSATMRAMLTSRVARDPDLRRRVTVVDGAAQDLVLPERLSAVVIFGVAGHLTVPERVALWKRLADRLPDGAPIVVELMGVSSPRHIPPVMSLRETIGRQTYEWWIGGEPTEGDAMRFTTTWKVLRDGRTVREVADSYDWHTFDVARLAREAGMTSRRITEAGGRPIPEIGVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWS5</accession>
    <name>Q9EWS5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0773</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625075.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027347.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9EWS5"/>
    <dbReference type="STRING" id="100226.SCO0773"/>
    <dbReference type="GeneID" id="1096196"/>
    <dbReference type="KEGG" id="sco:SCO0773"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.764"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_0_11"/>
    <dbReference type="InParanoid" id="Q9EWS5"/>
    <dbReference type="OMA" id="TCIGAGQ"/>
    <dbReference type="PhylomeDB" id="Q9EWS5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC14338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="66" mass="6691" checksum="A391E4954231D851" modified="2001-03-01" version="1">MHIGIDKDTCIGAGQCALTAPGVFTQDDDGYSTLRPGREDGGGSALVREAARACPVGAITVSERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2W6</accession>
    <name>Q9F2W6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4595</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628757.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029751.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4595"/>
    <dbReference type="GeneID" id="1100035"/>
    <dbReference type="KEGG" id="sco:SCO4595"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4667"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2W6"/>
    <dbReference type="OMA" id="LNPFPKN"/>
    <dbReference type="PhylomeDB" id="Q9F2W6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="46"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="287"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="544"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC08296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="645" mass="69195" checksum="37D3657B1249CA15" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F357</accession>
    <name>Q9F357_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2418</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAC12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626663.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976388.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2418"/>
    <dbReference type="GeneID" id="1097852"/>
    <dbReference type="KEGG" id="sco:SCO2418"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2459"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026704_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F357"/>
    <dbReference type="OMA" id="FQFYLCG"/>
    <dbReference type="PhylomeDB" id="Q9F357"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="354" mass="37260" checksum="F73AD843A52C20AA" modified="2001-03-01" version="1">MTGADHAHTRRRPLTGPLVKSLVFVVVTALATTVLGLSVAGTSVDSGTGTSTYKALFTDVTGLVDGDSVRISGVTVGEVTDVRVVDRRTAQVTFTVRDDRTLPRSTTAAVKYLNMVGQRYVSLGRGSGDLAGTLPEGGTVPLDRTTPALDLTLLFNGFKPLFEGLSPKDVNDLAGSIVQVLQGEGATVDSLIRHVGSLGTTVAAKDKVIGEVVENLTTVLDTLNDREDGFDDLVVTLQKLVTGFNQDRKPLGEAVAAMGDLTTVTAGLLEDGRAPLKKDVQELGRLSAGLGEHTPQIEDFLEKSPAKMTALARLSSYGSWFNLYLCEARVSGVSTSDGSKPPTGIAITESRCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3I3</accession>
    <name>Q9F3I3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO2798</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627028.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976002.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2798"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1098232"/>
    <dbReference type="KEGG" id="sco:SCO2798"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2856"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="InParanoid" id="Q9F3I3"/>
    <dbReference type="OMA" id="VEQWITL"/>
    <dbReference type="PhylomeDB" id="Q9F3I3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="433"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC10107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="52105" checksum="4A29E1679980909A" modified="2001-03-01" version="1">MLESATPVTPVTFPPAFLWGAATSAYQIEGAVREDGRTPSIWDTFSHTPGKTAGGDTGDVAVDHYHRYRDDVALMKDLGLGAYRFSISWPRVQPTGRGPAVQRGLDFYRRLVDELLAAGIKPAVTLYHWDLPQELEDAGGWPERDTAYRFAEYAQIVGEALGDRVEQWITLNEPWCAAFLGYASGVHAPGRTDPAAALRAAHHLNLAHGLGTVALRSVMPARNSVAISLNTSVVRPLSQSPADLAAARKIDDLSGGIFHGPILHGAYPQTLLEATAPLTDWSFVQDGDLGQIRQPIDAICLNYYTPTVVSAADADSRAPRADGHGASDHSPWPAAEDVAFHQPPGERTEMGWTVDPTGLHELIMRYNREAPGMPLYISENGAAYDDKPGADGTVHDPDRVAYLNGHLTAVRQAIADGADVRGYYLWSLLDNFEWAYGYEKRFGAVYVDYASQQRTPKSSALWYGRAARTGTLPPVDAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBL0</accession>
    <name>Q9FBL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5148</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629296.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030084.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5148"/>
    <dbReference type="GeneID" id="1100589"/>
    <dbReference type="KEGG" id="sco:SCO5148"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5231"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058823_0_0_11"/>
    <dbReference type="OMA" id="RGFRIHD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="33049" checksum="A57927D47DEBEFFC" modified="2001-03-01" version="1">MSGSRPEPEGHLAEQHLGDRLSALVDGELGHDARERVLAHVATCPKCKAEVDAQRRLKNVFAEAAPPAPSESFLARLQGLPGGGDSDGGGSPFSGLPGGFGASAASGVFGPRRDERFEFDYVPAGSHTPVLPSATSGRGFRIHEVGRHESDRSASRGLRFAFAAAGAVSLAAIALGGVTLGTPDTTTEARGSGSGSNVTPLRTPGSAAATGSESQRRRTAGPLLGQGQRALGDLPVASTTASAPLLPGMPAPAGGDARQQAVRALTTPVTAGAAAMSPLIRPLEAVPPLSLSSWSAAPEVRPPGLLAAPDPAPSPYPAASPAASSSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBS2</accession>
    <name>Q9FBS2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7170</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631229.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031477.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7170"/>
    <dbReference type="CAZy" id="CBM6">
        <property type="family name" value="Carbohydrate-Binding Module Family 6"/>
    </dbReference>
    <dbReference type="GeneID" id="1102608"/>
    <dbReference type="KEGG" id="sco:SCO7170"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7270"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019781_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBS2"/>
    <dbReference type="OMA" id="TEIHHNW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011459">
        <property type="entry name" value="DUF1565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07602">
        <property type="entry name" value="DUF1565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176695" evidence="3">
        <location>
            <begin position="30"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="4">
        <location>
            <begin position="657"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC01659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="786" mass="82079" checksum="70FA95DF4686F3D1" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBU7</accession>
    <name>Q9FBU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ECF sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7144</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631203.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971999.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7144"/>
    <dbReference type="GeneID" id="1102582"/>
    <dbReference type="KEGG" id="sco:SCO7144"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7246"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_3_11"/>
    <dbReference type="InParanoid" id="Q9FBU7"/>
    <dbReference type="PhylomeDB" id="Q9FBU7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC01633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="245" mass="27077" checksum="AD398764C42AC687" modified="2001-03-01" version="1">MSAPSPETTTPAGTPAARPAEGDLDTALHVFLAQRNRLFRIAYRIVGDAAGAEDVVQEAWVRWQLTDRAEVKNPVAFLTTTTTRLAINVIQSGRRRHETPSEPRFADLGDLASSDDPMLRAERTAAIESALALLMARLTPDRLAAYVLRKGFDYTYTELAKLLRISAPNARVVVHRAQARLDSERERPIPVESHRRLVTAFRTAADTGDLDGLVRLLVPEERVRRLAQPSRRPVGPAHVPARQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC64</accession>
    <name>Q9FC64_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7122</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631183.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972021.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7122"/>
    <dbReference type="GeneID" id="1102560"/>
    <dbReference type="KEGG" id="sco:SCO7122"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7222"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105788_4_1_11"/>
    <dbReference type="PhylomeDB" id="Q9FC64"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="17852" checksum="BD4E320BE3ED4398" modified="2001-03-01" version="1">MRREPRIIPIGPGQLTRTVAMHRRCSPQTLWSRYHRAMADPRTYVPTLLSRPGSVHLAALGATGRIVAVGHLMPDHTAAEAALLVEDSWQGRGLGTRLLQHLGEHARAGGWTTLYGLFLAGDERIDAMLRHAPVPVQRTEEGGAVTARVRVHDLTAHASVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCB5</accession>
    <name>Q9FCB5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO1252</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977578.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1252"/>
    <dbReference type="GeneID" id="1096675"/>
    <dbReference type="KEGG" id="sco:SCO1252"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1252"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="InParanoid" id="Q9FCB5"/>
    <dbReference type="OMA" id="HTVVGEM"/>
    <dbReference type="PhylomeDB" id="Q9FCB5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="282"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC01476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="36548" checksum="DA6D56C70F542369" modified="2001-03-01" version="1">MTAVQLLIGLATLVVNAFFVGAEFALISVRRSQVEPYAEEGDTRAKRVLWGLEHVSALLAAAQLGITLCTLVLGIVAEPAIAHLLEPVFHAVGVPSGAGHAVSFVLALALATYLHMLLGEMVPKNIALAEPVRSALVLGPPLVALSRALRPVIFTVNALANGLLKLLRVEAKNEVAATFTDAELAEIVKDAGEAGLIDDRARERLRDALELGRRPVRDVVLPLERVVHARVGITPEQLERLSAQSGFSRFPVVDDGRRIVGYLHVKDALDASPRDLPFRLRDMRPIARVRERTPLDDVLTAMRRSRTHLAAVLGSDGRLAGLVTMEDVLRELFGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH0</accession>
    <name>Q9FCH0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4199</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628374.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974772.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4199"/>
    <dbReference type="GeneID" id="1099639"/>
    <dbReference type="KEGG" id="sco:SCO4199"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4263"/>
    <dbReference type="eggNOG" id="ENOG502ZGNH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077681_1_0_11"/>
    <dbReference type="OMA" id="HGEQTVR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="22808" checksum="849E0940A5DB96C1" modified="2001-03-01" version="1">MAITDDLRKTFSDPTPLYFAAGTADLAFQQAKKVPVLVEQLRAEAPARIDAVRNTDPKAVQEKATARVKETQGSLQAKANELFGNLDADFKKLGETAQDLALRSVGVAAEYAVKARETYEKVAERGEHAVRTWRGQAADGIEDLAEDVEDLAVAVEPAKPAPARPATPKPATAKSEPVRVTEDRSAAAKKTPAPRKAPAKKNTTAKKTTPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3H0</accession>
    <name>Q9K3H0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative pyruvate dehydrogenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1270</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625557.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027684.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1270"/>
    <dbReference type="GeneID" id="1096693"/>
    <dbReference type="KEGG" id="sco:SCO1270"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1270"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_11"/>
    <dbReference type="InParanoid" id="Q9K3H0"/>
    <dbReference type="OMA" id="YVFSNHR"/>
    <dbReference type="PhylomeDB" id="Q9K3H0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="40"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB99150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="35108" checksum="161B9DA6004615D7" modified="2000-10-01" version="1">MNVTSASPAVDLGPAGEPEAGVVPRPLSRLSDADLGTLLMIRHFELAVLELFSQGRLHGTTHTCLGQEYIPVALYPLLDEGDYVFSNHRGHGHYLARFHDPHGLLAEIMGRAGAVCHGVGGSQHIYRDRYLSTGVQGQSLPVAVGVGLHLKQAEPGRIAVVHIGDGTWGEGAVYEALNMAQLWQVPVLVVVEHNGIAQSTPTERQMSGTVAARAAAFGVGHLRIDSVDVTDVRAALTPVVEQVRDRHRPYVVECVTHRVGPHSKGDDTRPAEVRERAARHDWYRRYRQDRPAQFAAADQAQAEAVAAVVREVGARPASRWEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X3</accession>
    <name>Q9K3X3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029611.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099811"/>
    <dbReference type="KEGG" id="sco:SCO4371"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4439"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097062_1_0_11"/>
    <dbReference type="OMA" id="WSVRWVF"/>
    <dbReference type="PhylomeDB" id="Q9K3X3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="187" mass="20493" checksum="89C028C6724DE08A" modified="2000-10-01" version="1">MTTTEPTTEPTTEATTKPLTGERADLLETLAKHRHFLRFTTRDLTDEQAGLRTTVSELCLGGLIKHTAAAERNWTDFIVNGPSAMGDFTAMTEADWARRADEFKMLPGETLAGVLDDYAEVARRTEELIAALPDLGAAHPLPKAPWFEADTEWSARRVLLHVIAETAQHAGHADIIREALDGAKSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K418</accession>
    <name>Q9K418_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1081</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625375.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027564.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1081"/>
    <dbReference type="GeneID" id="1096504"/>
    <dbReference type="KEGG" id="sco:SCO1081"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1078"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_11"/>
    <dbReference type="InParanoid" id="Q9K418"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="PhylomeDB" id="Q9K418"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB95300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="32313" checksum="E2434FF36B4CB6CD" modified="2000-10-01" version="1">MAEVLVYVDHVDGAVRKPTLELLTLARRVGEPVAVALGGGAGDTAATLAEHGAAKVLTHEAAEYADYLVVPKVDALQAAVAAVSPAAVLVPSSAEGKEIAARLALRLGSGVITDAVDLEAGDEGPVATQSVFAAAFTTKSRVSKGTPVITVKPNSAAVEAAPAAGAVEALSVTFSAAATGTKVTSRTPRESTGRPELTEAAIVVSGGRGVNGAENFAIIEALADSLGAAVGASRAAVDAGWYPHTNQVGQTGKSVSPQLYIASGISGAIQHRAGMQTSKTIVAINKDAEAPIFELVDYGVVGDLFDVVPQLTEEVKTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4B2</accession>
    <name>Q9K4B2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629354.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5207"/>
    <dbReference type="GeneID" id="1100648"/>
    <dbReference type="KEGG" id="sco:SCO5207"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5291"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_11"/>
    <dbReference type="InParanoid" id="Q9K4B2"/>
    <dbReference type="OMA" id="RDIIRCW"/>
    <dbReference type="PhylomeDB" id="Q9K4B2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15353" checksum="FAE58BB418E358E5" modified="2000-10-01" version="1">MDHRQEVAPPMLVREVMSTVVLTIGPAHTLRQAAALMSARRVGAAVVYDPDAGGIGILTERDVLVSVGRGQDPDTERTHGHTTTDVVFAAPTWTVEEAAGAMAHGGFRHLIVLDGGEPVGIVSVRDIIRRWAPARSPHNAPAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4F7</accession>
    <name>Q9K4F7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GCV_T domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4181</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628357.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974789.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4181"/>
    <dbReference type="GeneID" id="1099621"/>
    <dbReference type="KEGG" id="sco:SCO4181"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4245"/>
    <dbReference type="eggNOG" id="COG0354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_6_0_11"/>
    <dbReference type="InParanoid" id="Q9K4F7"/>
    <dbReference type="OMA" id="RHHELGP"/>
    <dbReference type="PhylomeDB" id="Q9K4F7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="34674" checksum="9B0F1D36A216F3F5" modified="2000-10-01" version="1">MKSPLLSLPGAVPAEGVDEGVAAHYGDLFREQRALADGTGFVDLSHRGVLAVTGDDRLSWLHLLLTQHVSDLPAGQATEALILSANGHIEHALYLVDDGTTVWAHVEPGSQEALIAYLESMKFFYRVEVADRTADTALVHLPAGSIAQAPASAVVRETPYGRDLFLPREELEAFAAQAGPAAGILAHEALRVEQHRPRLGFETDHRTIPHELGWIGTAVHLQKGCYRGQETVARVQNLGKPPRRLVFLHLDGSEVHLPPNGAEIRLADDGPDGRKIGFVTTSVRHHELGPVALALVKRNVPVDARLMAEETAAAQETVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4I9</accession>
    <name>Q9K4I9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO7236</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631292.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031531.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7236"/>
    <dbReference type="GeneID" id="1102674"/>
    <dbReference type="KEGG" id="sco:SCO7236"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7336"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K4I9"/>
    <dbReference type="OMA" id="LKHTQWA"/>
    <dbReference type="PhylomeDB" id="Q9K4I9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB94050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="554" mass="61467" checksum="D607B1154C894F5F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXT7</accession>
    <name>Q9KXT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4304</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628476.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974670.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4304"/>
    <dbReference type="GeneID" id="1099744"/>
    <dbReference type="KEGG" id="sco:SCO4304"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4372"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KXT7"/>
    <dbReference type="OMA" id="SIMLLHP"/>
    <dbReference type="PhylomeDB" id="Q9KXT7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB93064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="25780" checksum="AC9F6352377F82E8" modified="2000-10-01" version="1">MGQLEGRTAVVTGGGTGIGLASAVRLADEGAHVFITGRRKEALDKAVEIIGAGRVTAVAGDVSDPADLDRLYEAVRARGRGLDVVFANAATASLVPLEEITEERFEEIFGVNVRGTLFTVQKALPLLNDGASVILNASTAADNGAEAFSLYAASKAAVRTFARGWANELKGRGVRVNAISPGPVDTPGITNLFGESNAPTVHTKLAGDTAIGRMGRPEEVAAVVAFLASDQSSFVLGANWYVDGGENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXV1</accession>
    <name>Q9KXV1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative possible trehalose-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628462.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029560.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4290"/>
    <dbReference type="CAZy" id="GT20">
        <property type="family name" value="Glycosyltransferase Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="1099730"/>
    <dbReference type="KEGG" id="sco:SCO4290"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4358"/>
    <dbReference type="eggNOG" id="COG0380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_7_1_11"/>
    <dbReference type="InParanoid" id="Q9KXV1"/>
    <dbReference type="OMA" id="HFSHTPW"/>
    <dbReference type="PhylomeDB" id="Q9KXV1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="462" mass="50281" checksum="7E32B174E9A53724" modified="2000-10-01" version="1">MASSFGAAQVLVASNRGPVSYEVREDGSLHAKRGGGGLVSGLSAIGPDAGALWVCSALSDGDREAVRRGVGEDGVRMLDVPADVHADAYNGIANSVLWFVHHMLYQTPLEPVFDAEFRRQWASYEAYNRAFAEALAEEAAEGAVAIVQDYHLTLVPGMLRELRPDLRIGHFSHTPWAPLDYFRLLPDDIAEQVLRGMLGADRLGFLTRRWADAFTACCDAVVGGLGGTEIGVHGLGADGDFLRKRSHEADVEERMAELREQIGEGRRTIVRVDRTELSKNIVRGLLAYRELLAGRPEWRERVVHVAFAYPSRQDLAVYREYTAEVERVANAVNEEFGTPGWTPVVLNLKDDFARSLAAYRLADVALVNPVRDGMNLVAKEVPVVSDTGCALVLSREAGAYEELGEDAVVVNPYDVVGTADALHAALGLPAGDRAERSKRLAAAGTALPPARWFLEQLEALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY02</accession>
    <name>Q9KY02_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7339</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631393.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031596.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7339"/>
    <dbReference type="GeneID" id="1102777"/>
    <dbReference type="KEGG" id="sco:SCO7339"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7443"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069623_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KY02"/>
    <dbReference type="OMA" id="VFGAPCW"/>
    <dbReference type="PhylomeDB" id="Q9KY02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="29960" checksum="7DB2B005B7C5EDA7" modified="2000-10-01" version="1">MTAGGRDQDATAMNHDTTSSTRGESLLSTHSVYGAPCWVSLTSRDLEATEDFYSAVLGWRWRPVRLGEPFRIALADGVPVAGIAAVAAMWQMAVAWTPYFAVRSADEAVSRAQERGGTAAVGPISLPPGRAALLADRDGATFGIWEGELFSDWDAWRTKRPAFIRLHTRDAFDAAIFYGEIFEWASGQGCEVRYEGDEVVLRHEGEVVARIESGALGAAPDPAVRPHWQVHFAVEDVTACARAAERHGGSVLSLGADEAVLRDADGAQFTVTARRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY20</accession>
    <name>Q9KY20_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2370</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626617.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976434.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2370"/>
    <dbReference type="GeneID" id="1097804"/>
    <dbReference type="KEGG" id="sco:SCO2370"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2409"/>
    <dbReference type="eggNOG" id="ENOG5032TPU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117223_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KY20"/>
    <dbReference type="OMA" id="VGKDWSG"/>
    <dbReference type="PhylomeDB" id="Q9KY20"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17197" checksum="8BA0B98B76D83023" modified="2000-10-01" version="1">MAEDIYRNMIRRQPVSATADHAEERTNPAARLGFQPGQVVQEIGYDDDVDQELREAIEGAVEGELVDEDYEDVADAVVLWFRDDDGDLTDALVDATTYIEEGGSILLLTPKTGRDGYVEASDISEASTTAGLTASKSVSVGKDWSGSRLATPKAAKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY84</accession>
    <name>Q9KY84_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5018</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629170.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973959.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100459"/>
    <dbReference type="KEGG" id="sco:SCO5018"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5096"/>
    <dbReference type="eggNOG" id="ENOG5030MRE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2773990_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="7581" checksum="16571C66600DC4A3" modified="2000-10-01" version="1">MHGDSSWHTTRSVPSIVVVVLIVIWTVFAVQWKEKDCALVPTSYLLVITHGTPSVFEGCGDHAIDVTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYG2</accession>
    <name>Q9KYG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626944.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976090.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2710"/>
    <dbReference type="GeneID" id="1098144"/>
    <dbReference type="KEGG" id="sco:SCO2710"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2765"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_5_2_11"/>
    <dbReference type="InParanoid" id="Q9KYG2"/>
    <dbReference type="OMA" id="GFCYPYG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="24344" checksum="B41275632857CA17" modified="2000-10-01" version="1">MYHSVGDRSDDPYRITVTPDRLDAQLGWLRRRGLRGVPVGELLAARARGGGGDLVGLTFDDGYADFVEHALPCLRRHGCGATLFVLPGRLGGVNSWDPLGPRKPLLTADGIRRAAAEGVEIGSHGLTHVDLTTADDTTLTAETAESRALLSELAGAPVTGFCYPYGTVDARAADAVRAAGYTYACAIDPGPLTGPYALPRVHVGQNDTPVRLLLKTRLHRLRRRAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYU4</accession>
    <name>Q9KYU4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3201</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2014" name="Biochem. Biophys. Res. Commun." volume="450" first="513" last="518">
            <title>Structure and regulatory targets of SCO3201, a highly promiscuous TetR-like regulator of Streptomyces coelicolor M145.</title>
            <authorList>
                <person name="Xu D."/>
                <person name="Waack P."/>
                <person name="Zhang Q."/>
                <person name="Werten S."/>
                <person name="Hinrichs W."/>
                <person name="Virolle M.J."/>
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            <dbReference type="DOI" id="10.1016/J.BBRC.2014.06.003"/>
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        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 23-236</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2015-10" db="PDB data bank">
            <title>Apo-form of SCO3201.</title>
            <authorList>
                <person name="Waack P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 23-236</scope>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="236" mass="24978" checksum="5528671D46F5B9FC" modified="2000-10-01" version="1">MSSTIPALPGPEPGPGPGPAGPVSLTERRKAETRMEIARAAARLFVGQGLRATRAEDIARAAGVAPRTFYRYFATKEEAVAPLYALGAERWVRAVREAPAELSPPEALERAVRHTLTPGAGVSAPSWEWARTLIRLAESSPALRKVWAEVCHSTERGLVQALAARMSGGDDNVAVRLAASPRLHFAAAVAGASVRVAAEHWASSSPQGARSPLEQALLNLEVLRGFAWEAGPAEEG</sequence>
</entry>
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    <accession>Q9KYW0</accession>
    <name>Q9KYW0_STRCO</name>
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        <submittedName>
            <fullName evidence="6">Putative Na+/H+ antiporter</fullName>
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        <name evidence="6" type="ordered locus">SCO3185</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="PubMed" id="12000953"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="363"/>
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    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="410"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88982.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="467" mass="49504" checksum="7A68EF5FA2A0810A" modified="2000-10-01" version="1">MSVTRSGAPPVEPYDVAIVGAGVVGCAIARRLAHHPGLRVALVEAQDDVGQGTSKANTAILHTGFDAVPGSLEARLVREGSRELAAYAAESGIPVERVGALLVAWDEEQLAALPRLAEKARRNEYHDTRVLGAADLYAREPRLGPGALGALHVPGESIICSWTTTLAYATQAVRAGVDLYLEAPITHAGHADGVHRLDTPRGPLHARRLVNAAGLHADTLDRSLGHDDFTVTPRRGQLVVHDTFARALVRHILLPVPTALGKGVLVAPTVYGNVLLGPTAEDLDDKGDTGSTAEGLRRLREQGRRILPALLEEEVTAVYAGLRAATGHDDYRIAAHPGQGYVTVGGIRSTGLTASLAIAAHVTGLLADTGLDLGARRPLEPVRMPNLGEAFPRPHQRPDLVAADPEYGTLVCHCERVSRGEIRDALAGPVPPRSLDGLRRRTRARAGRCQGFYCGAAVRALFEEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZI8</accession>
    <name>Q9KZI8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1157</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625449.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027617.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1157"/>
    <dbReference type="DNASU" id="1096580"/>
    <dbReference type="GeneID" id="1096580"/>
    <dbReference type="KEGG" id="sco:SCO1157"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1155"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZI8"/>
    <dbReference type="OMA" id="VEYAGRM"/>
    <dbReference type="PhylomeDB" id="Q9KZI8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="22545" checksum="2EF5DE7136AD3EC8" modified="2000-10-01" version="1">MRSERSERSDDTDGDTTALALKILVAGGFGVGKTTLVGAVSEIRPLRTEELLSEAGRLVDDTDGIDRKVTTTVAMDFGRITIRSGLSLYLFGTPGQDRFWFLWDELAQGALGAVVLADTRRLADCFPAVDYFEHRHIPFVVAVNCFTGARRHDEYSVLRALDLDPGTPVVLCDARDRDSGKEVLIRLVEYAGRMHTARLLDSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZM7</accession>
    <name>Q9KZM7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative heat shock protein (Hsp90-family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1405</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027769.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1405"/>
    <dbReference type="GeneID" id="1096831"/>
    <dbReference type="KEGG" id="sco:SCO1405"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1415"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028672_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZM7"/>
    <dbReference type="OMA" id="WTRPAQV"/>
    <dbReference type="PhylomeDB" id="Q9KZM7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="615" mass="66715" checksum="CA5F3FF3F7F9EBAE" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0A2</accession>
    <name>Q9L0A2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2011" name="Chem. Biol." volume="18" first="165" last="176">
            <title>Enzymatic extender unit generation for in vitro polyketide synthase reactions: structural and functional showcasing of Streptomyces coelicolor MatB.</title>
            <authorList>
                <person name="Hughes A.J."/>
                <person name="Keatinge-Clay A."/>
            </authorList>
            <dbReference type="PubMed" id="21338915"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2010.12.014"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) IN COMPLEX WITH AMP</scope>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028356.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="PDB" id="3NYQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.43 A"/>
        <property type="chains" value="A=1-485"/>
    </dbReference>
    <dbReference type="PDB" id="3NYR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.45 A"/>
        <property type="chains" value="A=1-485"/>
    </dbReference>
    <dbReference type="PDBsum" id="3NYQ"/>
    <dbReference type="PDBsum" id="3NYR"/>
    <dbReference type="SMR" id="Q9L0A2"/>
    <dbReference type="STRING" id="100226.SCO2444"/>
    <dbReference type="GeneID" id="1097878"/>
    <dbReference type="KEGG" id="sco:SCO2444"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2485"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_11"/>
    <dbReference type="InParanoid" id="Q9L0A2"/>
    <dbReference type="OMA" id="VHDHERI"/>
    <dbReference type="PhylomeDB" id="Q9L0A2"/>
    <dbReference type="EvolutionaryTrace" id="Q9L0A2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="400"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:16027"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB86109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3NYQ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3NYR"/>
        </source>
    </evidence>
    <sequence length="485" mass="50563" checksum="0C3878FD87E1D158" modified="2000-10-01" version="1">MSSLFPALSPAPTGAPADRPALRFGERSLTYAELAAAAGATAGRIGGAGRVAVWATPAMETGVAVVAALLAGVAAVPLNPKSGDKELAHILSDSAPSLVLAPPDAELPPALGALERVDVDVRARGAVPEDGADDGDPALVVYTSGTTGPPKGAVIPRRALATTLDALADAWQWTGEDVLVQGLPLFHVHGLVLGILGPLRRGGSVRHLGRFSTEGAARELNDGATMLFGVPTMYHRIAETLPADPELAKALAGARLLVSGSAALPVHDHERIAAATGRRVIERYGMTETLMNTSVRADGEPRAGTVGVPLPGVELRLVEEDGTPIAALDGESVGEIQVRGPNLFTEYLNRPDATAAAFTEDGFFRTGDMAVRDPDGYVRIVGRKATDLIKSGGYKIGAGEIENALLEHPEVREAAVTGEPDPDLGERIVAWIVPADPAAPPALGTLADHVAARLAPHKRPRVVRYLDAVPRNDMGKIMKRALNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0F0</accession>
    <name>Q9L0F0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4692</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974272.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4692"/>
    <dbReference type="GeneID" id="1100133"/>
    <dbReference type="KEGG" id="sco:SCO4692"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4764"/>
    <dbReference type="eggNOG" id="ENOG5032TWE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111590_0_0_11"/>
    <dbReference type="OMA" id="HTAREAY"/>
    <dbReference type="PhylomeDB" id="Q9L0F0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23302" checksum="97AB240E6800D258" modified="2000-10-01" version="1">MARYTEALTVERGGFRIKVPESWWEFDVRPESRDDSIRRMVDDRIRRYPELKPSRAAYVTFLQKAASDAWKSGALYCGCMAESFGGDTPITGSVTVSLIGGRTSTGDPLPTDPGAIAAQLAVKEAKKPGDSWRKVTTVDIPGVGPAARTRGVEDIPVPDDALNRTVRAVLMQTYIPVPGQEGKVALVAGSSQVLDLADSFFDIFDAITSTFRFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0I4</accession>
    <name>Q9L0I4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleotide-sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4773</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974201.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4773"/>
    <dbReference type="GeneID" id="1100214"/>
    <dbReference type="KEGG" id="sco:SCO4773"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4846"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_11"/>
    <dbReference type="InParanoid" id="Q9L0I4"/>
    <dbReference type="OMA" id="WDVIRCA"/>
    <dbReference type="PhylomeDB" id="Q9L0I4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="304"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="405" mass="43078" checksum="7F79D513B0972371" modified="2000-10-01" version="1">MPADLAVIGLGPYGLPLAQAAVAAGIPTLGYRTGPEADPLTPAEVRRMLATGFRTPTGPAGPAELGRVRTAVICAPTPPGADGGLDLTQVEAAARTLAAHMRPHTTVILESPVRPGTTEDFLRPLLEQGSGLRAGRDFHLAYSPSRVDPGNRDFTPANTPKVIGGLTPACTESAAAFYSRLTDKVVRARGPREAETVQLLETNFRHVNIALVNEMAVLCDDLGVDLWDVLRCAETKPFGFHAFRPGPGVGGHSVAQDLTGRAPHSLRMVELAQQVNAQMPRYVVQRAAALLNEHGKSARGARILLLGVTYKADLADQQATPAEEIATRLMSMGAAVSYHDPHIPSWNVADRPVPRADSLYEAAADADLTILLQQHRTYDLQGLSVKAQLLLDTRGATPTGAAHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L197</accession>
    <name>Q9L197_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7378</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631430.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031622.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7378"/>
    <dbReference type="GeneID" id="1102816"/>
    <dbReference type="KEGG" id="sco:SCO7378"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7483"/>
    <dbReference type="eggNOG" id="ENOG5031DUR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054928_1_0_11"/>
    <dbReference type="OMA" id="REQIDWE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="236" mass="25692" checksum="A73F321F8359DF5F" modified="2000-10-01" version="1">MRQPADDQATGRRAGVSELRPADGDRGPALRREAPHEDLPLDRNQAILQAAKQVGSTLKKAEHPFALAGSVAVYAHGGTQNLQHDVDFCIRPEDADAVAATLREAGLTVYTPPEDWLLKADCLGQQVDLIFELAHEPVTTALLDRARDLSVDSVLMPVLSPTDLLRGLLAAFSEHHCDFGAVLPIARTLREKIDWAALRRDCGDDPMPAAFFFVLERLEIIPPAGPPATASKEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1V4</accession>
    <name>Q9L1V4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6831</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630902.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031216.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6831"/>
    <dbReference type="GeneID" id="1102270"/>
    <dbReference type="KEGG" id="sco:SCO6831"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6941"/>
    <dbReference type="eggNOG" id="ENOG5031VI6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182306_1_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046030">
        <property type="entry name" value="DUF5988"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19450">
        <property type="entry name" value="DUF5988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="91" mass="10475" checksum="66088782DF45645B" modified="2000-10-01" version="1">MTSTILTTAQAHSHNILRSDGDRAAEPNIFLAGGKDIPEDQRMHEVEPLTDRVKLNVENRYEHFEATSEVREVDGRSLRVYGWIYRTYVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2A9</accession>
    <name>Q9L2A9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integrase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5411</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629550.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030228.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5411"/>
    <dbReference type="DNASU" id="1100851"/>
    <dbReference type="GeneID" id="1100851"/>
    <dbReference type="KEGG" id="sco:SCO5411"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5492"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_15_0_11"/>
    <dbReference type="InParanoid" id="Q9L2A9"/>
    <dbReference type="OMA" id="WVEEISA"/>
    <dbReference type="PhylomeDB" id="Q9L2A9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="468" mass="51081" checksum="9FA3C49784A259CB" modified="2000-10-01" version="1">MEHMTEQRAVIAIYLRLSRESDDSTSLETQRSFAHRWLLAHGYDPADAVEYIDASVSGAKPLEARKGMAALMAARPTVVVAWKLDRFARSVSDFLRLVAWAEAHGASIATTDNAIDTTTATGRMVATVLAALAEWERNAIASRITDGHATRRSQGRWSSGRPPFGYRIERRDGAAYLAIDDDQAAKIRKAVAALVNGSTVAATARLTGLSEPQWRRLLKSPTLRGQRAHKGELVCEVDGITPVKFAEPILSAAELLKVRERMLALATGQDRAPRRATPMCSGMAFCHRCAGKLNGGTSDKGVPLYRCKAGHVTIYAETLDSRVESEFLTTFGSYAETVIRLEGGNDLSAELLEAKEQAERLAARMATAGPLMLGTLESLAQDLEDTHARLRAAHDPDVREVQVATGRTMAQAWEMYDVPDRSRLLAGMGLRVSLHPRQLADRLTITWGPTPEEAPEAEWDGLALSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2J7</accession>
    <name>Q9L2J7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0711</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625016.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027309.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0711"/>
    <dbReference type="GeneID" id="1096134"/>
    <dbReference type="KEGG" id="sco:SCO0711"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.699"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041278_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L2J7"/>
    <dbReference type="OMA" id="LATWLEC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="362"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="426" mass="46108" checksum="9F007833BC02AC34" modified="2000-10-01" version="1">MQHAVRSRAAIRTGLTPVPRPRTPGVTSLIDADALRVLHRAARALLDDLPDLTDRLMALLREQEPAYRAALTKDPTATWQEAHRSLRHSVASLLDPRGARDAARRCSWRIGAARAEQGLPLDALLHAFRLGGSLVWQRLVEETSRAAPEDVRLLVHVAADVWNFVDEHCTLVADAYRQTEWQLGRRRENRVRQLAAGLLDGTGRIADLPEAARALGLPEHGRYVVVAVAGGPPARPDAARAAVPPGSRVHWHAGAETDYGIVSLGDHDGLPEPHRPEAAQDAPVPGLRVGVGSPVDGLAAVGDARRLADTALTICPPAGGTVRLADQLPAALVVSSPELGRALAEKVLGPLLRLESADRDVLLDTLTTWLDCDGSAQRAGERLYCHRNTVLNRLRRCEQLTGRSLARPADLVEFSLALTARRVLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCV2</accession>
    <name>Q9RCV2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0859</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB65640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625159.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978000.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0859"/>
    <dbReference type="GeneID" id="1096282"/>
    <dbReference type="KEGG" id="sco:SCO0859"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.851"/>
    <dbReference type="eggNOG" id="COG2847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132120_0_0_11"/>
    <dbReference type="OMA" id="LAPICAC"/>
    <dbReference type="PhylomeDB" id="Q9RCV2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB65640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="17439" checksum="437F87799B8C86E1" modified="2000-05-01" version="1">MTTSAWTPTPRRLADTALAALAPICACVLALGALAVWTATGNAGTPARIGVTDARLFLPSRGVPETAAFFKITNTGGAQDRLVGVTSSEVPEGISLSSHRMTAGGAAHRRPTESLPVPAEGTLDMSPLSSDVTVPAAARWQAGDLVPFTLHFEHSGRMEVLAVVVRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCY7</accession>
    <name>Q9RCY7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0923</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977936.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0923"/>
    <dbReference type="GeneID" id="1096346"/>
    <dbReference type="KEGG" id="sco:SCO0923"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.917"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_0_11"/>
    <dbReference type="InParanoid" id="Q9RCY7"/>
    <dbReference type="OMA" id="WRRIKVP"/>
    <dbReference type="PhylomeDB" id="Q9RCY7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="47"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="6">
        <location>
            <begin position="514"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="649" mass="72020" checksum="50847EC7B7A43DF0" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD07</accession>
    <name>Q9RD07_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0904</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625203.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027432.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0904"/>
    <dbReference type="GeneID" id="1096327"/>
    <dbReference type="KEGG" id="sco:SCO0904"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.898"/>
    <dbReference type="eggNOG" id="ENOG5033BFE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190418_0_0_11"/>
    <dbReference type="OMA" id="MEKMMRE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="99" mass="11144" checksum="D998AA310349C3F1" modified="2000-05-01" version="1">MTLAAGAEELGVLVGAVGAAGFFGLMIVIVWQVAATWRDRMPAAREGQYKELATRYARLLEDTVELQRRTVEEQRQTLDELTRSRLAVGSMEKMMREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD49</accession>
    <name>Q9RD49_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0633</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624944.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027262.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0633"/>
    <dbReference type="GeneID" id="1096056"/>
    <dbReference type="KEGG" id="sco:SCO0633"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.615"/>
    <dbReference type="eggNOG" id="COG5343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075802_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RD49"/>
    <dbReference type="OMA" id="VYQMWLI"/>
    <dbReference type="PhylomeDB" id="Q9RD49"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="25971" checksum="9EB9E41411B52919" modified="2000-05-01" version="1">MRTEDLHSLTGAYALHALPDDEREAFERHLAGCATCEQEAREFAAATARLGLAATVVPAPALRDRVLHRVTTVRQVPPGGGTAEKARRVVPRGRGLARWALAACVAAAAGLGGTAVWQYERAQDAGQRAAQAERRAETLAGVLAAPDAESRTARLADGASGTLVVSERQDRAVFLASGMAEPPRGKVYQLWFDDHGTMRSAGLMDPGSTSQAVLMDGAVDGAAGVGITVEPAGGSKQPTSDPIALLSMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDC2</accession>
    <name>Q9RDC2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable amino acid ABC transporter protein, integral membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2829</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627058.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975971.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2829"/>
    <dbReference type="GeneID" id="1098263"/>
    <dbReference type="KEGG" id="sco:SCO2829"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2887"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_4_11"/>
    <dbReference type="InParanoid" id="Q9RDC2"/>
    <dbReference type="OMA" id="QLVPMWA"/>
    <dbReference type="PhylomeDB" id="Q9RDC2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014342">
        <property type="entry name" value="Ectoine_EhuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03004">
        <property type="entry name" value="ectoine_ehuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB65559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25473" checksum="C8C43BA1C6DDAE66" modified="2000-05-01" version="1">MTSGLWELVLQGVWVTVQLLFFSSLLATAVSFVVGIARSHRLWIVRFLAGFYTEVFRGTSALVMIFWVFFVLPPAFGWQLVPMWAGTLALGLTYGAYGSEIVRGSLAAVDPAQKEGGIALSFTPWQRMKLILLPQAVPEMIPPFSNLLIELLKGTALVSIMGMGDLAFSANLVRLALQESAEIYTYVLLIYFVIAFLLTRVMRGLEKKLKAGVGKAPKKKTAAVRVPEGSGVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDD6</accession>
    <name>HRCA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hrcA</name>
        <name type="ordered locus">SCO2555</name>
        <name type="ORF">SCC77.22c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626793.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976249.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RDD6"/>
    <dbReference type="SMR" id="Q9RDD6"/>
    <dbReference type="STRING" id="100226.SCO2555"/>
    <dbReference type="GeneID" id="1097989"/>
    <dbReference type="KEGG" id="sco:SCO2555"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2600"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDD6"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="PhylomeDB" id="Q9RDD6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000182538" description="Heat-inducible transcription repressor HrcA">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <sequence length="338" mass="36575" checksum="12BD83F913E9F871" modified="2000-05-01" version="1">MLSERRLKVLRAIVQDYVGTEEPVGSKALTERHNLGVSPATVRNDMAALEDEGFIAQPHTSAGRIPTDKGYRLFVDKLAGVKPMTAPERRAIQNFLEGAVDLDDVVARTVRLLAQLTRQVAVVQYPSLTRSTVRHVELLSLAPARLMLVLITDTGRVEQRMVDCPAPFGEASLADLRARLNSRVAGRRFADVPALVEDLAEPFEAEDRGTVSTVLSTLLETLVEENEERLMIGGTANLTRFGHDFPLVIRPVLEALEEQVVLLKLLGEAKDPGVTVRIGHENAHEGLNSTSVVSVGYGSGGEAVAKLGVVGPTRMDYPGTMGAVRAVARYVGQILAES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ68</accession>
    <name>TATA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tatA</name>
        <name type="ordered locus">SCO1633</name>
        <name type="ORF">SCI41.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625908.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977193.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ68"/>
    <dbReference type="SMR" id="Q9RJ68"/>
    <dbReference type="STRING" id="100226.SCO1633"/>
    <dbReference type="TCDB" id="2.A.64.2.2">
        <property type="family name" value="the twin arginine targeting (tat) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1097064"/>
    <dbReference type="KEGG" id="sco:SCO1633"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1648"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_4_3_11"/>
    <dbReference type="InParanoid" id="Q9RJ68"/>
    <dbReference type="OMA" id="WHWLILA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000058969" description="Sec-independent protein translocase protein TatA">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="95" mass="10039" checksum="8D7F693355A70F3F" modified="2000-05-01" version="1">MFGRLGAPEIILILVVIILLFGAKKLPDMARSLGKSARILKSEAKAMKSEAKADDAAPADPPNPEQSAAQRTIQAAPGDVTSSRPVTEPTDTTKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-25" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ87</accession>
    <name>Y678_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>UPF0337 protein SCO0678</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO0678</name>
        <name type="ORF">SCF91.38c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624987.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027290.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ87"/>
    <dbReference type="SMR" id="Q9RJ87"/>
    <dbReference type="STRING" id="100226.SCO0678"/>
    <dbReference type="GeneID" id="1096101"/>
    <dbReference type="KEGG" id="sco:SCO0678"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.664"/>
    <dbReference type="HOGENOM" id="CLU_135567_1_1_11"/>
    <dbReference type="OMA" id="NAKQMGD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000210047" description="UPF0337 protein SCO0678">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="57" mass="6130" checksum="99600F43E5DDE8CE" modified="2000-05-01" version="1">MAGNEKSRAKMEQAKGKAKEAAGRAVGNERMTAEGRAAQSKGDARQAKEKGKDVFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK8</accession>
    <name>Q9RJK8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027070.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0380"/>
    <dbReference type="GeneID" id="1095803"/>
    <dbReference type="KEGG" id="sco:SCO0380"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.356"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_34_2_11"/>
    <dbReference type="InParanoid" id="Q9RJK8"/>
    <dbReference type="OMA" id="RNARDQS"/>
    <dbReference type="PhylomeDB" id="Q9RJK8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="13865" checksum="6E1D933C31328B3E" modified="2000-05-01" version="1">MDMHDSGGLTPEQTERVVAIAMDLAREGGTEQLVEFVQHGLPVDVRDPAGNSLLMLAAYHGHADTVRTLIRHGADPDLRNDRDQSPIAGALFKGADDVVAVLRQAGADLDSGTPTARAAAAMFGREHLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJX5</accession>
    <name>Q9RJX5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1195</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625485.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977636.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1195"/>
    <dbReference type="GeneID" id="1096618"/>
    <dbReference type="KEGG" id="sco:SCO1195"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1194"/>
    <dbReference type="eggNOG" id="ENOG502ZRPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193873_0_0_11"/>
    <dbReference type="OMA" id="MAPTIHE"/>
    <dbReference type="PhylomeDB" id="Q9RJX5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6553" checksum="75F97D8BFF6572CF" modified="2000-05-01" version="1">MAVSISVVLLLSILAVLFLRNGGLKVSHALVCLLLGFYLASTSIAPTINSGLTATADIVGSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJZ3</accession>
    <name>Q9RJZ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gntR-famly transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1177</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625467.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027631.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1177"/>
    <dbReference type="GeneID" id="1096600"/>
    <dbReference type="KEGG" id="sco:SCO1177"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1176"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_4_11"/>
    <dbReference type="InParanoid" id="Q9RJZ3"/>
    <dbReference type="OMA" id="DDPVPSH"/>
    <dbReference type="PhylomeDB" id="Q9RJZ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26184" checksum="96FDE1D97035C84A" modified="2000-05-01" version="1">MSRGRAEIVVHFPTMQQRVVDELGRRIVGGAWEPGVPLPVEDALAAEIGVSRGVLREAVKALAAKGMLHVRPRTGTRVLSPEHWNHLDRDVLRWKQAGDATALLRDTSELRRIVEPEAARLAAERAGSEDVRVLYDALNAMEAAAARPGRRGYVEADIAFHRALLDAGGNRLLGSLGRAVEIALEHSFLVSTRTPGAVEASLPAHRAVVQAVEAHDPAAAAAAVLAIVEAAEDEIARSPGMPDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK16</accession>
    <name>Q9RK16_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0490</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36408">
        <property type="entry name" value="T36408"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624807.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027154.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0490"/>
    <dbReference type="ESTHER" id="strco-SCO0490">
        <property type="family name" value="A85-IroE-IroD-Fes-Yiel"/>
    </dbReference>
    <dbReference type="GeneID" id="1095913"/>
    <dbReference type="KEGG" id="sco:SCO0490"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.470"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024314_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RK16"/>
    <dbReference type="OMA" id="DRAGWRH"/>
    <dbReference type="PhylomeDB" id="Q9RK16"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="363" mass="38823" checksum="57CE16430A6728AC" modified="2000-05-01" version="1">MRWAGADAFAAFGLTAVPGTDAFWDGLTTPRSIPDGDGWTTLFLRRGPRAASIVFESWSAPVPLRRWRDTDCWYAEVRMPPRLRVTYRFVVGEEAYADPYNPAGAGGERSVAATPDAPAQPHWPLVGAGDVLPLPRVRLRWTSERLGGRRTVRVHPVGGGGPVVLLLDGDDWLYLHPATSAFDSAVASGEMPPVTLVFLPAGDRGAEFGCRPALWEAVRDELLPLVAGSGVRADPGRTVVAGQSLGGLSALYAALEFPELVSRVACQSASLWWTPGAADLPDPLGGPVGGAIAARLRARPDLSGLRIAFDVGEHERRMLPHCALVESLTEQAGATVRVSRSASGHDRAGWRHALLRDVAWALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK21</accession>
    <name>Q9RK21_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0485</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36403">
        <property type="entry name" value="T36403"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624802.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978380.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0485"/>
    <dbReference type="GeneID" id="1095908"/>
    <dbReference type="KEGG" id="sco:SCO0485"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.464"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RK21"/>
    <dbReference type="OMA" id="ERMWTRH"/>
    <dbReference type="PhylomeDB" id="Q9RK21"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="22558" checksum="B2CA5E5593D9A7F4" modified="2000-05-01" version="1">MPDSPTPGRRERKKAATRQAIADAALQLFLEHGFDRVSVRDVAERADVSTTTLFAHFPSKESLVFDREQEVDAALAAAVRERPDGQGVVEALRAHALESWVPIVTDPRRARFTALVSDTPALREYSERMWMRHADTLSTVIAEELDREPDDSACAALARFVLEIPALTTGRHDPRATVETVFDLLLHGWRSQAGPRPPQADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK45</accession>
    <name>Q9RK45_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0334</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624658.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027027.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0334"/>
    <dbReference type="GeneID" id="1095757"/>
    <dbReference type="KEGG" id="sco:SCO0334"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.308"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2119666_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="11508" checksum="E7DE8F21D0E243B3" modified="2000-05-01" version="1">MLQLAGTTAATTAVGPLAGGSPAHGAALPPARAGIGAPAFPFGLGRVRPTATLLDQGDGTCTIRDARGKLLPVQNDSPAAGAFVAQEADDGAADNRWRILRRTAIDTRVRVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKB6</accession>
    <name>Q9RKB6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627387.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028808.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3171"/>
    <dbReference type="ESTHER" id="strco-SCE87.22c">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1098605"/>
    <dbReference type="KEGG" id="sco:SCO3171"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3231"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RKB6"/>
    <dbReference type="OMA" id="FCENIVR"/>
    <dbReference type="PhylomeDB" id="Q9RKB6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="33051" checksum="D003BFC90FFB8ED3" modified="2000-05-01" version="1">MSRLLRVADGPYAPPVPARELTVTAADGARVHVEVHGPENAPAVVLAHGWCCSTAFWAAQIRELAADHRVIAYDQRGHGRSPANPAYGTEPLADDLEAVLEATLAPGERAVIAGHSMGGMTLMAAATRPAVREHAAAVLLTSTGSARLVASATVVPMRAGRVRTWLTRRILGSRAPLGPVTPLARRILKYGTMGPGSAPHMVDACARIVHSCPSRVRHGWSQVLDLLDLDHGVRELRMPAEIVVGTADRLTPPEHARALAAALPDCVGLTELPGVGHMTPVEAPDLVTGKIRALAATYIPSARGERAVPVEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKD3</accession>
    <name>Q9RKD3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SCO3154</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627370.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028798.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3154"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="GeneID" id="1098588"/>
    <dbReference type="KEGG" id="sco:SCO3154"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3215"/>
    <dbReference type="eggNOG" id="COG1928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021079_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKD3"/>
    <dbReference type="OMA" id="AGNHHPW"/>
    <dbReference type="PhylomeDB" id="Q9RKD3"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="92"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="396"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAB59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="591" mass="66290" checksum="DE7F1707C0071897" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL57</accession>
    <name>Q9RL57_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0429</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624750.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0429"/>
    <dbReference type="GeneID" id="1095852"/>
    <dbReference type="KEGG" id="sco:SCO0429"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.405"/>
    <dbReference type="eggNOG" id="COG0667">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RL57"/>
    <dbReference type="OMA" id="LDEGIAW"/>
    <dbReference type="PhylomeDB" id="Q9RL57"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004033">
        <property type="term" value="F:aldo-keto reductase (NADP) activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="32696" checksum="196554D0C1BD2D57" modified="2000-05-01" version="1">MTSTGTPSSSRATHGGTPRPGGAGVLAGRTVSRIGYGAMQLERLHADRAAAVALVRRAVERGVDHLDTAQFYGDGFVNEVIRAALRPADDVVVVSKVGAAPDPGGPLPLRPAQRPEELRASVEDNLRSLGTDRIPVVNLRRLDTGPGLRAEGDQRVDLDDQLAVMTALRDEGKIGAIGLSSVTPDGLRRALPAGIVCVQNAYSVVSRDDEDMLALCSAEGVAWVPYFPLGGAFPAMPKVADEPAVHTVANRLGVTPAQVGLAWLLHHAPNVLLIPGTADAGHLDANLAVGEIALDASSLAALDAVRSRSADVPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S216</accession>
    <name>Q9S216_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1784</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36887">
        <property type="entry name" value="T36887"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977038.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1784"/>
    <dbReference type="GeneID" id="1097215"/>
    <dbReference type="KEGG" id="sco:SCO1784"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1803"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169722_0_0_11"/>
    <dbReference type="OMA" id="MATIEEC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12613" checksum="A89B76097FB3278E" modified="2000-05-01" version="1">MATTEECRAALDKLSDTMRGAEGDVRSATELDRSVSCHITDLDVTFAGRMADGRIDVRETLEGPPRERAEIRLAMTGDDLVALVAGELNFARAWGSGRVKLEAGLRDLLRLRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S237</accession>
    <name>Q9S237_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO1763</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36866">
        <property type="entry name" value="T36866"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626034.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027960.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1763"/>
    <dbReference type="GeneID" id="1097194"/>
    <dbReference type="KEGG" id="sco:SCO1763"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1781"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="InParanoid" id="Q9S237"/>
    <dbReference type="OMA" id="TIDCACH"/>
    <dbReference type="PhylomeDB" id="Q9S237"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="11">
        <location>
            <begin position="38"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="13181" checksum="C548CEB1657FAB1D" modified="2000-05-01" version="1">MTQTPARRTVLLCTGAGAAALCVGCGGGGDSSGASPGQELVRTGDVPVAGGKILTDEKIVVTQPRQGEFKAFSAVCTHQGCIVSDVRDGTIDCACHGSRFAVADGSVVRGPATEPLPGKRITVEGNSVRLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-02-17" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S281</accession>
    <name>SERB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <shortName evidence="1">PSP</shortName>
            <shortName evidence="1">PSPase</shortName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1808</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2015" name="Proc. Natl. Acad. Sci. U.S.A." volume="112" first="E1974" last="E1983">
            <title>Panoramic view of a superfamily of phosphatases through substrate profiling.</title>
            <authorList>
                <person name="Huang H."/>
                <person name="Pandya C."/>
                <person name="Liu C."/>
                <person name="Al-Obaidi N.F."/>
                <person name="Wang M."/>
                <person name="Zheng L."/>
                <person name="Toews Keating S."/>
                <person name="Aono M."/>
                <person name="Love J.D."/>
                <person name="Evans B."/>
                <person name="Seidel R.D."/>
                <person name="Hillerich B.S."/>
                <person name="Garforth S.J."/>
                <person name="Almo S.C."/>
                <person name="Mariano P.S."/>
                <person name="Dunaway-Mariano D."/>
                <person name="Allen K.N."/>
                <person name="Farelli J.D."/>
            </authorList>
            <dbReference type="PubMed" id="25848029"/>
            <dbReference type="DOI" id="10.1073/pnas.1423570112"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dephosphorylation of phosphoserine (P-Ser) in vitro. Also catalyzes the dephosphorylation of phosphothreonine (P-Thr) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36772">
        <property type="entry name" value="T36772"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977014.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S281"/>
    <dbReference type="SMR" id="Q9S281"/>
    <dbReference type="STRING" id="100226.SCO1808"/>
    <dbReference type="GeneID" id="1097242"/>
    <dbReference type="KEGG" id="sco:SCO1808"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1829"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S281"/>
    <dbReference type="OMA" id="FAAHAGC"/>
    <dbReference type="PhylomeDB" id="Q9S281"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0718">Serine biosynthesis</keyword>
    <feature type="chain" id="PRO_0000435472" description="Phosphoserine phosphatase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q58989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25848029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="25848029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="CAB50876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="410" mass="43150" checksum="16006A0193C0CFC7" modified="2000-05-01" version="1">MSASQTSDVPTLLVKIFGKDRPGITAGLFDTLAAYSVDVVDIEQVVTRGRIVLCALVTEPPRGLEGDLRATVHSWAESLKLQAEIISGIGDNRPRGFGRSLVTVLGHPLTAEATAAIAARITESGSNIDRIFRLAKYPVTAVEFAVSGVETEPLRTALATEAAALGVDIAVVAAGLHRRAQRLVVMDVDSTLIQDEVIELFAAHAGCEDEVAEVTAAAMRGELDFEQSLHARVALLAGLDASVVDKVRAEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDALQEQLGLDFAQANTLEIVDGRLTGRVTGEIVDRAGKARLLRRFAAAAGVPLSQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNVPFLDTVLYLLGITREEVEAADTLADDLGDGPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2D6</accession>
    <name>Q9S2D6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0277</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB54162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36465">
        <property type="entry name" value="T36465"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026982.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0277"/>
    <dbReference type="GeneID" id="1095701"/>
    <dbReference type="KEGG" id="sco:SCO0277"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.251"/>
    <dbReference type="eggNOG" id="COG3340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244705_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2D6"/>
    <dbReference type="OMA" id="DFSIFPH"/>
    <dbReference type="PhylomeDB" id="Q9S2D6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB54162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24621" checksum="8B7300B8EFC5A95B" modified="2000-05-01" version="1">MNFLLTASGLRNETLRDALRDMLGKPFGSANVVFVPTASVADPGDHGWVVADMNRLHGLGWREFDILELNGLPQQMVLDRLLHADVVYVEGGNHYHLARSITGNGLVDGFLEALQSRVYVGVSAGSMIFSRNLTGHSADVIGDATDLHVLGATSVEPPFGLFDWYLKPHLYSPDFPERDDAWADRITARADFPIYFIDDETAVRVRDGKADVVSEGRWRFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2L5</accession>
    <name>Q9S2L5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1988</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35733">
        <property type="entry name" value="T35733"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626249.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028081.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1988"/>
    <dbReference type="GeneID" id="1097422"/>
    <dbReference type="KEGG" id="sco:SCO1988"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2015"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_21_1_11"/>
    <dbReference type="InParanoid" id="Q9S2L5"/>
    <dbReference type="OMA" id="WIDQLYV"/>
    <dbReference type="PhylomeDB" id="Q9S2L5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="20293" checksum="BF6F1E5DC848BE41" modified="2000-05-01" version="1">MNREAGARAGADVDAGPSDDAGAGVSTDAGAEAVVLRRARAVDARAAADVWLRSFAAALPTVVRPRSDSEVRAYFRHVVVERYETWVAQEDDGAVAGVMVLEGEELSQLYLAPERRGCGIGDRFVALAKERRADGLSLWTFQVNAPARRFYERHGFRAVEWTDGDRNEEREPDVRYEWRPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2W0</accession>
    <name>Q9S2W0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2096</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34966">
        <property type="entry name" value="T34966"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626355.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028136.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2096"/>
    <dbReference type="GeneID" id="1097530"/>
    <dbReference type="KEGG" id="sco:SCO2096"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2129"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008359_0_1_11"/>
    <dbReference type="InParanoid" id="Q9S2W0"/>
    <dbReference type="OMA" id="GFCVHFS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="481"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="797" mass="84164" checksum="9DBC3D659B94F9E9" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX09</accession>
    <name>Q9WX09_STRCO</name>
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        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T36273"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3325"/>
    <dbReference type="GeneID" id="1098759"/>
    <dbReference type="KEGG" id="sco:SCO3325"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3385"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042900_1_1_11"/>
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    <dbReference type="OMA" id="PIPTDGY"/>
    <dbReference type="PhylomeDB" id="Q9WX09"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="142"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="38494" checksum="01CD5FC4F10B31D2" modified="1999-11-01" version="1">MADAKVIPFDDDRSRGSRGAGSRRRGGPAESAPAGEGPVGDVQPLPVRGAAAQDPAPGPDESPEPRSAVGDGGDRDEGLERRLAAGLSFLRRRLTGDYEVDDFGYDAELTDQVLMSLLRPVYEKYFRVEVKGVENIPAEGGALIVANHSGTLPLDGLMMQVAVHDHHPADRHLRLLAADLVFVLPVVNELARKLGHTLACAEDAERLLAQGELVGVMPEGFKGIGKPFGERYKLQRFGRGGFVSTALRQGAPIVPCSIVGAEEIYPMIGNSKTLARLLGFPYFPLTPTFPWLGPLGAVPLPTKWTIQFGEPIPTDGYAPEAAEDPVLMFNLTDQVREQIQHTLYKLLVQRRSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7N8</accession>
    <name>Q9X7N8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6732</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35257">
        <property type="entry name" value="T35257"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031141.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6732"/>
    <dbReference type="GeneID" id="1102171"/>
    <dbReference type="KEGG" id="sco:SCO6732"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6839"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_15_3_11"/>
    <dbReference type="InParanoid" id="Q9X7N8"/>
    <dbReference type="OMA" id="PFRYMDT"/>
    <dbReference type="PhylomeDB" id="Q9X7N8"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="323"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="504"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB40682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="726" mass="77664" checksum="156BAA1AA4F764E9" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7R8</accession>
    <name>Q9X7R8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7282</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35326">
        <property type="entry name" value="T35326"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631338.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031562.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7282"/>
    <dbReference type="GeneID" id="1102720"/>
    <dbReference type="KEGG" id="sco:SCO7282"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7384"/>
    <dbReference type="eggNOG" id="COG3865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_11"/>
    <dbReference type="InParanoid" id="Q9X7R8"/>
    <dbReference type="OMA" id="DQDEVDY"/>
    <dbReference type="PhylomeDB" id="Q9X7R8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17685" checksum="289F1C9EF7EBFE7D" modified="1999-11-01" version="1">MSTDGFTTCLWFDGDAEDAAHFYVSVFKNSGIGAVTRYPEGAPQPAGSVLTVEFTANGQKFVGLNGGPQFKFNEAISFQVTCEDQDEVDHYWTRLTEGGGEDGPCGWLKDRFGVSWQVVPRRLEEMFRDPDPARVARANKAMMSMRKLDIAALEQAYAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X833</accession>
    <name>Q9X833_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6066</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35858">
        <property type="entry name" value="T35858"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630175.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972855.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6066"/>
    <dbReference type="GeneID" id="1101507"/>
    <dbReference type="KEGG" id="sco:SCO6066"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6167"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X833"/>
    <dbReference type="OMA" id="WNDLAIG"/>
    <dbReference type="PhylomeDB" id="Q9X833"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="19446" checksum="9A66B384F59C3DF2" modified="1999-11-01" version="1">MKILIAGGFGVGKTTMVGSVSEIAPLRTEEPLTAAGLDVDDLAGIEEKRATTVALDFGRITIGRDVVLYLFGTPGQQRFWFMWNDLAIGALGAVVLVDVRRPESSFAAIDFFERRGIPFVVAVNGFHGRHPYPAAEIREALALPEHVQVLLCDARERTSSRDVLIALIDQLIDAAAGAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8E4</accession>
    <name>Q9X8E4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3271</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36231">
        <property type="entry name" value="T36231"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627483.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975563.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1098705"/>
    <dbReference type="KEGG" id="sco:SCO3271"/>
    <dbReference type="eggNOG" id="ENOG5032ET8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2304350_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="100" mass="11352" checksum="C6F13BB26FC4D8A8" modified="1999-11-01" version="1">MTQPAEPSSLGGHRGTRGSLRDPDQPLARPKVRRMADDAQLCPECSQPLKSGGLVLSKRDDDGLRVCRSVWRCADRHTWWQWADRPEEVLESCPVPELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8I2</accession>
    <name>Q9X8I2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3402</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36328">
        <property type="entry name" value="T36328"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627608.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975431.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3402"/>
    <dbReference type="GeneID" id="1098839"/>
    <dbReference type="KEGG" id="sco:SCO3402"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3465"/>
    <dbReference type="eggNOG" id="ENOG5033CMQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123281_2_1_11"/>
    <dbReference type="OMA" id="WAGARLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="16831" checksum="C6BABDBD97DC6DA2" modified="1999-11-01" version="1">MKELRIRVLAGVFVVAGILSWAGARLWNSVGTLPSVPLAAPVVLALIAVILLATALSIRARLRAQRDRVPDAKGVDPMMAARAVVFGQASALVAALVAGMYGGTGVFLLEYLDIPARRDQAIYAGASVVAGIAVIAAALFMERVCRLPEDEDDDHPGAASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="148" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8I4</accession>
    <name>Q9X8I4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">SCO3404</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36330">
        <property type="entry name" value="T36330"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627610.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975429.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3404"/>
    <dbReference type="MEROPS" id="M41.015"/>
    <dbReference type="GeneID" id="1098841"/>
    <dbReference type="KEGG" id="sco:SCO3404"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3467"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_1_11"/>
    <dbReference type="InParanoid" id="Q9X8I4"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="PhylomeDB" id="Q9X8I4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB42757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="668" mass="72093" checksum="F62F3AAAF02D68DF" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8M2</accession>
    <name>Q9X8M2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3365</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36376">
        <property type="entry name" value="T36376"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627573.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028937.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3365"/>
    <dbReference type="GeneID" id="1098802"/>
    <dbReference type="KEGG" id="sco:SCO3365"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3428"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_2_11"/>
    <dbReference type="OMA" id="DFVQGHM"/>
    <dbReference type="PhylomeDB" id="Q9X8M2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="31465" checksum="0C8BC7EED4AB302F" modified="1999-11-01" version="1">MANIQSLDPTASPLDYYGWELRRQREAHGLKQGQLGDIIFCTGSLVGQIETTKKVPTRDFSERVDAALGTDGLFSRLIGLVLRSQLPTWFQPYAEMEAKAAYISTYQAQLVYGLLQTEEYARAVLATGKPGQLDSLLAARMERQRILAWEKPPVALVILDEAVLHRPIGGDDVMWRQLAHLLEFTNHRWMRIQVLPLTSGEHPGLAGAFNILRFEDHPDVFYTEDMMSGHMTANPETIKEASLNYAHLQADALSVKDSAALIARVMEERYADRTERDPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8U8</accession>
    <name>Q9X8U8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3912</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36599">
        <property type="entry name" value="T36599"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628098.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975020.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X8U8"/>
    <dbReference type="STRING" id="100226.SCO3912"/>
    <dbReference type="GeneID" id="1099348"/>
    <dbReference type="KEGG" id="sco:SCO3912"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3986"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X8U8"/>
    <dbReference type="OMA" id="VHPWADV"/>
    <dbReference type="PhylomeDB" id="Q9X8U8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="461" mass="49024" checksum="1428F5C413A0E6A9" modified="1999-11-01" version="1">MTTSQGELLPTTRRALTHRIAVAQAEGRTPSLVAAVVRGGRAVWHGARTSVDGHGPDENVQYRIGSITKTFTAVLVLRLRDEGVLDLGDPLEKHLPGTGAGEATIAELLAHSGGLAAESPAPWWERTPGSLRPELADVLGKQPLLHPVGRRHHYSNPGYTLLGALVEKLRGAPWEEVLQREVLDPLELRRTGTRPSAPHAGGWAVHPWADVMLAEPVEDLGRMAPAGQLWSTTGDLARFAVFLTLGDDRVLGAATVREMRAPAAPAESADVVDGAAYGLGLQIQHRDGRLLVGHSGSLPGFLANLTIGVEDDVAAVVLTNCTSGPLLAGVGADLVRIVAEAEPRIPEPWRPLREVDSAVLELAGQWYWGTHAFALRLTPDGGVSLGPLSGQGRRSRFRANGDGSWTGLEGYYAGESLRAVRRPDGTVSHLDLGSFVFTRQPYDEGASVPGGVDPEGWRGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X916</accession>
    <name>Q9X916_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3551</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36672">
        <property type="entry name" value="T36672"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627749.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029078.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3551"/>
    <dbReference type="GeneID" id="1098987"/>
    <dbReference type="KEGG" id="sco:SCO3551"/>
    <dbReference type="HOGENOM" id="CLU_104210_0_0_11"/>
    <dbReference type="OMA" id="ADHWADA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="3">
        <location>
            <begin position="92"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="22299" checksum="7B49BC5A8DEEB4F0" modified="1999-11-01" version="1">MRAATGGGRIGGGRAVRGRTGGGRSARGRTGEGRAARGRTGGGRAVKDQTGRGRAVRAATGGGQAMGDATGEGGAVRDGAGGSRAMNASDRGSATVWSVAAIAVLCFVFGIVLALGQAVVARHRAAGGADLAALAAADDWAQGATAACERAGRVARAQEVRLVRCVLTGQISDVTAASGSGPFTAEVRARAGPAPLETPAPAPPLPSARSLPPTPPAAPAPPPPPPAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X942</accession>
    <name>Q9X942_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3589</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB41737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36698">
        <property type="entry name" value="T36698"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627785.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975349.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X942"/>
    <dbReference type="STRING" id="100226.SCO3589"/>
    <dbReference type="GeneID" id="1099025"/>
    <dbReference type="KEGG" id="sco:SCO3589"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3644"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="InParanoid" id="Q9X942"/>
    <dbReference type="OMA" id="FDTMLAQ"/>
    <dbReference type="PhylomeDB" id="Q9X942"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="147"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB41737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="39523" checksum="7AA3083539207485" modified="1999-11-01" version="1">MDRRPGLSVRLKLTLSYAGFLTLAGVLLLVAVGVFLLDQGWLLTNERGAVRATPGTVFLRSFAPTAAWVMAFLLVFGLVGGWFLAGRMLAPLDRITEATRTAATGSLSHRIRLPGRRDEYRELADAFDEMLARLEAHVAEQRRFAANASHELRTPLAVSKAILDVARTDPHQDPGEIIDRLHAVNTRAIDLTEALLLLSRAGQRSFTREQVDMSLLAEEATETLLPFAEKHGVTLETRGHVTLALGSPALLLQLTTNLVHNAIVHNLPGRGRVWIHTAAGPRTTRLVVENTGDLISPHQASTLTEPFQRGTERIHTDHPGVGLGLAIVNTITQAHDGTLTLTPRHSGGLRVTVELPAAAPHTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAF1</accession>
    <name>Q9XAF1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane cell-cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5302</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35627">
        <property type="entry name" value="T35627"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629444.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973669.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5302"/>
    <dbReference type="GeneID" id="1100742"/>
    <dbReference type="KEGG" id="sco:SCO5302"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5388"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_3_1_11"/>
    <dbReference type="InParanoid" id="Q9XAF1"/>
    <dbReference type="OMA" id="TGMAMPF"/>
    <dbReference type="PhylomeDB" id="Q9XAF1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB45622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="446" mass="46836" checksum="A50088394201BACA" modified="1999-11-01" version="1">MAQADTPAPVARLPRRRGIELALILMAVLLSVFGYCNVGLAQHDALPPGAAGYGAGLGVLALLAHLAVRLRAPYADPLLLPIGVLLNGLGLVLIYRLDLETPGDRAAPTQLVWSTLGVALFIVVVLLLRDHRVLQRYAYVCVAAALALLTVPIFFPAVNGARIWIRIEGFSIQPGEFAKVLLAVFFAAYLAANRSALAYAGRRVWRLQLPTGRVLGPILAVWLVSVGVLVLERDLGTSLLFFGLFVVLLYVATGRTGWIAVGLLLASLGAVAVGWLEPHVHSRVEDWLHPFASIEAGHGPNQLAQSLFAFAAGGVTGTGLGLGHSVLIGFAVKSDFILATAGEELGFLGLSAVFLLYGLLVERGYRAGLGARDPFGRLLAVGLSSIVALQVFVIAGGVTGLIPLTGMAMPFLAQGGSSVVTNWAIVALLIRVSHAARSQAGGRAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAJ2</accession>
    <name>Q9XAJ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3610</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35378">
        <property type="entry name" value="T35378"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975329.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3610"/>
    <dbReference type="ESTHER" id="strco-SC66T3.21C">
        <property type="family name" value="Prolyl_oligopeptidase_S9"/>
    </dbReference>
    <dbReference type="GeneID" id="1099046"/>
    <dbReference type="KEGG" id="sco:SCO3610"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3668"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAJ2"/>
    <dbReference type="OMA" id="HEVYRYD"/>
    <dbReference type="PhylomeDB" id="Q9XAJ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="402"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="606" mass="65726" checksum="269E2643D3B96619" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAR8</accession>
    <name>Q9XAR8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34610">
        <property type="entry name" value="T34610"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628738.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029739.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100016"/>
    <dbReference type="KEGG" id="sco:SCO4576"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4648"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAR8"/>
    <dbReference type="OMA" id="FNWQLQS"/>
    <dbReference type="PhylomeDB" id="Q9XAR8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB44517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="22407" checksum="309DD0C0CB5F2A00" modified="1999-11-01" version="1">MSVSPKASAPDWPTPPEGGWTADDLDRLPNLPPHTELIDGSLVFVSPQTLFHSRAVDFFNWQLQSLAPEEFEVIREFTIDIDRQNRPEPDVIVVRGDVVDDPEQTRYPAEAVTLAVEVVSPESVSRDRETKPLKYARAGIAHYWRVENEKGLAVVHAFELEPTTRAYTSVGIFRERMKVSAPFPMDLDLTAVKPRRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBF3</accession>
    <name>Q9ZBF3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6460</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35947">
        <property type="entry name" value="T35947"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630545.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030938.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6460"/>
    <dbReference type="GeneID" id="1101899"/>
    <dbReference type="KEGG" id="sco:SCO6460"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6560"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_11"/>
    <dbReference type="InParanoid" id="Q9ZBF3"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="PhylomeDB" id="Q9ZBF3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA22769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="638" mass="65321" checksum="30AAA36EE558ED98" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBJ8</accession>
    <name>Q9ZBJ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6476</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35963">
        <property type="entry name" value="T35963"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630559.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030949.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6476"/>
    <dbReference type="GeneID" id="1101915"/>
    <dbReference type="KEGG" id="sco:SCO6476"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6577"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383455_0_0_11"/>
    <dbReference type="OMA" id="YALHPVR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA22724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="21061" checksum="6ABC3643C5570AC1" modified="1999-05-01" version="1">MDEELRALTERLRAESAASGVPDAAAVYDRLVATGDQDELAAVLTEPGHPLWARELAAFRLGVAGDRRAFESLVLLLNHRDPPRCASAAHALARLGDPRTARAAAALATNELRVAYALHPVRLLVELRAPEAVPALITTLERRLRPHDPYRRVALACVEGLGALGDDRAGPVLNDALAHPALAQAAVRALARIPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBV0</accession>
    <name>Q9ZBV0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6138</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34651">
        <property type="entry name" value="T34651"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630243.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030680.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6138"/>
    <dbReference type="GeneID" id="1101579"/>
    <dbReference type="KEGG" id="sco:SCO6138"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6242"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051806_4_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBV0"/>
    <dbReference type="OMA" id="ICAWHSI"/>
    <dbReference type="PhylomeDB" id="Q9ZBV0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="307" mass="32335" checksum="695544063E74952F" modified="1999-05-01" version="1">MTISGRRIRSVRCSPRHSSHGPDEGVPVRFVWQFLAVLVAYAIGGIAVQAVKDNDWLTLVVGLTSVALVVFVYAWVVRRTERREALDVALDGAAAKAGWGTLIGFGLFGAVITNLFASGYYEVDGLGSVQGAIGLVGFMAAAAATEEVVFRGVLFRIIEEHIGTYLALGLTGLVFGLMHLLNEDATLWGALAIAIEAGFMLAAAYAATRNLWLTIGVHFGWNFAAGGVFSTVVSGNGDSEGLLDATMSGPKLLTGGDFGPEGSVYSVGFGVLLTLVFLWLAHRRGNIVAFGSRRRAAGANSAATLPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZEP4</accession>
    <name>CSEB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulatory protein CseB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cseB</name>
        <name type="ordered locus">SCO3358</name>
        <name type="ORF">SCE94.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="33" first="97" last="107">
            <title>A putative two-component signal transduction system regulates sigE, a sigma factor required for normal cell wall integrity in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Paget M.S.B."/>
                <person name="Leibowitz E."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10411727"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01452.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION IN TRANSCRIPTIONAL ACTIVATION OF SIGMA E</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Member of the two-component regulatory system CseB/CseC involved in the stability of the cell envelope. CseB activates transcription of RNA polymerase sigma-E factor, in response to changes in the cell envelope.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Phosphorylated by CseC.</text>
    </comment>
    <dbReference type="EMBL" id="AJ131213">
        <property type="protein sequence ID" value="CAA10325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36369">
        <property type="entry name" value="T36369"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627566.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975477.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZEP4"/>
    <dbReference type="SMR" id="Q9ZEP4"/>
    <dbReference type="STRING" id="100226.SCO3358"/>
    <dbReference type="GeneID" id="1098795"/>
    <dbReference type="KEGG" id="sco:SCO3358"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3420"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="InParanoid" id="Q9ZEP4"/>
    <dbReference type="OMA" id="WGGDTRV"/>
    <dbReference type="PhylomeDB" id="Q9ZEP4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <feature type="chain" id="PRO_0000314481" description="Transcriptional regulatory protein CseB">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10411727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="234" mass="25382" checksum="2D714CFF98FAAC4F" modified="1999-05-01" version="1">MADQTHVLFVEDDDVIREATQLALERDGFAVTAMPDGLSGLESFRADRPDIALLDVMLPGLDGVSLCRRIRDESTVPVIMLSARADSIDVVLGLEAGADDYVTKPFDGAVLVARIRAVLRRFGHAGGGDRTEGAGAAETGGVLTFGDLEVDTDGMEVRRAGRPVGLTPTEMRLLLEFSSAPGTVLSRDKLLERVWDYGWGGDTRVVDVHVQRLRTKIGQDRIETVRGFGYKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O54140</accession>
    <name>O54140_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34826">
        <property type="entry name" value="T34826"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629996.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973147.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5874"/>
    <dbReference type="GeneID" id="1101316"/>
    <dbReference type="KEGG" id="sco:SCO5874"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5973"/>
    <dbReference type="eggNOG" id="ENOG5031MNQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="WRTRNPG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA16483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="29616" checksum="E1B667D38EC5B9E6" modified="1998-06-01" version="1">MTSLDKPTEETTEADDARAVTEAALFEAFGGVRGMIETVLPGLLFVTIFTLNNDLHMSAIAALAVSVVLVVVRLVMKDTVKHAFSGVFGVAFGVVFAMMTDNAKNFYLPGMLYTLGLALAYIVTSLAGVPLIGLILGPVFKENLSWRTRNPGRKKAYTKASYAWGLILLAKSAILFPLYWWADTEQLGWVLVTLKIPPFLLAVWLTWVFLAKAPAPIDVFAEMEAAEEAEKAEKAERERRERDQSEAGGALPGPSEADGEAADLRGGRHRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O69974</accession>
    <name>O69974_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5798</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35118">
        <property type="entry name" value="T35118"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629922.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973224.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5798"/>
    <dbReference type="GeneID" id="1101240"/>
    <dbReference type="KEGG" id="sco:SCO5798"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5889"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060114_0_0_11"/>
    <dbReference type="InParanoid" id="O69974"/>
    <dbReference type="OMA" id="LWDPDRM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174859" evidence="2">
        <location>
            <begin position="40"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA18335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="409" mass="42955" checksum="FF9AEF3D5FE14E5B" modified="1998-08-01" version="1">MRSIRPSFSTRGNRRGRRGTSSAAAAVALVSALALTATACEDGDPEAGGDASASASAADDGNGGIRIPDDIKDKLKEHGIDVDDWKNGAWKNWNKDDWLREAQDFVNPIIEGLWDPDRMRDAEEPDQEVDENDISGDQGVTDPEPAPVEAEAVPAKYHDNAATAGKLLFDSPKGSMVCSATVVKDPAHPGKSNMVWTAGHCVHAGKSGGWYRNIAFVPSYNDADKSVEELQNATKEELAPYGVWWGDWAQTSDQWIEQGGATGGDGASYDFAVIHVTPEKGSGGKSLEETVGAALPVDFDAPAVPEIESMKAIGYPAAPPYDGQKLYQCQDKPGRLSLNASDPTMYRIGCTMTGGSSGGGWVAAGSDGKPALVSNTSIGPVTAGWLAGPRLGDEAKGVFDAVSGKFAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O86529</accession>
    <name>O86529_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5548</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29078">
        <property type="entry name" value="T29078"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973447.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5548"/>
    <dbReference type="GeneID" id="1100988"/>
    <dbReference type="KEGG" id="sco:SCO5548"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5636"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_2_11"/>
    <dbReference type="OMA" id="QIRIFTV"/>
    <dbReference type="PhylomeDB" id="O86529"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="14617" checksum="A4EC9252D77071E8" modified="1998-11-01" version="1">MRREDIDPRFFGDRLAYNRAVLVEQPRRWLVVAGHEARDDEGGIAAVDDVRGQLRLTFRRLAETLDKAGFALSDLVQIRIFTVDIEAVTAHYDAVLDELAAADCRPASLLAEVRALSDPRMLVEIEGLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O86531</accession>
    <name>O86531_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="Biochem. Biophys. Res. Commun." volume="435" first="28" last="33">
            <title>Structural and genomic DNA analysis of a putative transcription factor SCO5550 from Streptomyces coelicolor A3(2): regulating the expression of gene sco5551 as a transcriptional activator with a novel dimer shape.</title>
            <authorList>
                <person name="Hayashi T."/>
                <person name="Tanaka Y."/>
                <person name="Sakai N."/>
                <person name="Watanabe N."/>
                <person name="Tamura T."/>
                <person name="Tanaka I."/>
                <person name="Yao M."/>
            </authorList>
            <dbReference type="PubMed" id="23618855"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2013.04.017"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29080">
        <property type="entry name" value="T29080"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629684.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973445.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="PDB" id="2DG6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=1-214"/>
    </dbReference>
    <dbReference type="PDBsum" id="2DG6"/>
    <dbReference type="SMR" id="O86531"/>
    <dbReference type="STRING" id="100226.SCO5550"/>
    <dbReference type="GeneID" id="1100990"/>
    <dbReference type="KEGG" id="sco:SCO5550"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5638"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102175_0_0_11"/>
    <dbReference type="OMA" id="TATIKYY"/>
    <dbReference type="EvolutionaryTrace" id="O86531"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2DG6"/>
        </source>
    </evidence>
    <sequence length="214" mass="23827" checksum="54F5793CD1160746" modified="1998-11-01" version="1">MRLADLSKRSGVSTATIKYYLREGLLPPGRQVNATTAEYDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDAEPDEADPAVAAARVEVDRLLELLGWETSRELAPLSPVHRSLVVAVAALRRLDYPWDAELMAPYGELMMEVARRDLDFMETHASEAEKVEMAVAAAVLFQPVLRALHRLAQEEESARRYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O86673</accession>
    <name>O86673_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6381</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34992">
        <property type="entry name" value="T34992"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630472.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6381"/>
    <dbReference type="GeneID" id="1101822"/>
    <dbReference type="KEGG" id="sco:SCO6381"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6489"/>
    <dbReference type="eggNOG" id="COG0121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049601_0_0_11"/>
    <dbReference type="OMA" id="SIRPWFV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004160370" evidence="2">
        <location>
            <begin position="23"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="447" mass="46712" checksum="809E0091B7834D80" modified="1998-11-01" version="1">MTPSRRALAVAAALTAALAAGACENVGMHAGRLCVQPADFGTGTLAGACPPIAPSSTRANHRTPVAPTAISQPFRPGTDLPPAATGFRPDTPTGQPAATDTEPRSAAGNGATTPLASTTPVPVPAGTAPGTGRLPFASATTAGLHNTYSPTAFRYLAQGLDTGTGMIEIDTWPDNTTKQWKVSHSHPHRNVNNCTPATTAAQLYSGTTHSNLETCLDDVRIWLRAHPGAGPLVVKLELKAGFATGQGMGPSQLDTLIAAHLGDMVFRPADLLPKPTGGSYATASDAARADNWPTRSELAGRVLLYAIPGSHTPHPDIELGRHLRDLAATGNIGRAQVFPAVHGATAGDPRTAYKDTAIRPWFVVFDGDATTYLDGLNTTWYDTNHYLLTMTDAHKVVPALSATRPSLAQARARTQQLATAHATIVSSDWHQLPNAQSLLLPRGPPQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O86779</accession>
    <name>COAA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Pantothenate kinase</fullName>
            <ecNumber>2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">coaA</name>
        <name type="ordered locus">SCO4738</name>
        <name type="ORF">SC6G4.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35567">
        <property type="entry name" value="T35567"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628896.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974235.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86779"/>
    <dbReference type="SMR" id="O86779"/>
    <dbReference type="STRING" id="100226.SCO4738"/>
    <dbReference type="GeneID" id="1100179"/>
    <dbReference type="KEGG" id="sco:SCO4738"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4809"/>
    <dbReference type="eggNOG" id="COG1072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053818_1_1_11"/>
    <dbReference type="InParanoid" id="O86779"/>
    <dbReference type="OMA" id="RKYTQVS"/>
    <dbReference type="PhylomeDB" id="O86779"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000194452" description="Pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="329" mass="37116" checksum="51346F19D82538D1" modified="1998-11-01" version="1">MISPVPSIPRSAHRQRPEATPYVDLTRPEWSALRDKTPLPLTAEEVEKLRGLGDVIDLDEVRDIYLPLSRLLNLYVGATDGLRGALNTFLGEQGSQSGTPFVIGVAGSVAVGKSTVARLLQALLSRWPEHPRVELVTTDGFLLPTRELEARGLMSRKGFPESYDRRALTRFVADIKAGKAEVTAPVYSHLIYDIVPDQRLVVRRPDILIVEGLNVLQPALPGKDGRTRVGLADYFDFSVYVDARTEDIERWYLNRFRKLRATAFQNPSSYFRKYTQVSEEEALDYARTTWRTINKPNLVENVAPTRGRATLVLRKGPDHKVQRLSLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O86830</accession>
    <name>O86830_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative polyamine ABC-transporter integral memb rane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5669</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35801">
        <property type="entry name" value="T35801"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629798.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030376.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5669"/>
    <dbReference type="GeneID" id="1101108"/>
    <dbReference type="KEGG" id="sco:SCO5669"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5755"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_3_11"/>
    <dbReference type="InParanoid" id="O86830"/>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="PhylomeDB" id="O86830"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA20220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="34051" checksum="B13D78116E3B80D3" modified="1998-11-01" version="1">MSTLTEAPPPLSPPAPEQKPPRRRGRWTPYWLLLPGILWLVVFFAAPMVYQASTSVQTGSLEEGYKVTWHFATYWDALTEYWPQFLRSVAYAASATVLCLLLGYPLAYLIAFRAGRWRNLIMILVIAPFFTSFLIRTLAWKTILADGGPVVGALNTLHVLDVTGWLGWTSGDRVLATPLAVVCGLTYNFLPFMILPLYTSLERIDGRLHEAAGDLYAKPSTVFRKVTFPLSMPGVVSGTLLTFIPATGDYVNASLLGSADTGMIGNVIQSQFLRVLDYPTAAALSFILMAAILAMVTFYIRKSGTEDLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-09-26" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>P58286</accession>
    <name>PAND_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">panD</name>
        <name type="ordered locus">SCO0978</name>
        <name type="ORF">SCBAC19F3.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625274.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027487.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P58286"/>
    <dbReference type="SMR" id="P58286"/>
    <dbReference type="STRING" id="100226.SCO0978"/>
    <dbReference type="PRIDE" id="P58286"/>
    <dbReference type="GeneID" id="1096401"/>
    <dbReference type="KEGG" id="sco:SCO0978"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.975"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115305_2_0_11"/>
    <dbReference type="InParanoid" id="P58286"/>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="PhylomeDB" id="P58286"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000023175" description="Aspartate 1-decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000023176" description="Aspartate 1-decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="139" mass="14617" checksum="43D12EA24321919C" modified="2001-09-26" version="1" precursor="true">MLRTLIKSKIHRATVTQADLHYVGSVTIDADLLDAADLLPGELVHIVDVTNGARLETYVIEGERGSGVIGINGAAAHLVHPGDLVILISYAQVTDAEARSLRPRVVHVDGDNRIVGLGADASEPVPGSDQERSPQAVSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q53867</accession>
    <accession>Q9S1M8</accession>
    <name>Y3923_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO3923</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3923</name>
        <name type="ORF">SCQ11.06</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="136" last="142">
            <title>Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Strohl W.R."/>
            </authorList>
            <dbReference type="PubMed" id="8550407"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / 1147</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC43612" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="U37580">
        <property type="protein sequence ID" value="AAC43612.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37176">
        <property type="entry name" value="T37176"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628108.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029310.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q53867"/>
    <dbReference type="SMR" id="Q53867"/>
    <dbReference type="STRING" id="100226.SCO3923"/>
    <dbReference type="GeneID" id="1099359"/>
    <dbReference type="KEGG" id="sco:SCO3923"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3997"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149791_1_1_11"/>
    <dbReference type="InParanoid" id="Q53867"/>
    <dbReference type="OMA" id="MSVGLYA"/>
    <dbReference type="PhylomeDB" id="Q53867"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205347" description="Uncharacterized protein SCO3923">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="105" mass="11538" checksum="ADA70B423D3A67CF" modified="2000-12-01" version="2">MKAFRLDELEAERAANDGAYLQFLRERNMSVGLYALDAGTTDSQKPHAQDEVYFVVSGRAAITVGMETTQVARGSVVYVPAGVAHKFHHISEDLRVLVVFSPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKJ0</accession>
    <name>Q7AKJ0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">SCO4724</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35553">
        <property type="entry name" value="T35553"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628882.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029827.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4724"/>
    <dbReference type="GeneID" id="1100165"/>
    <dbReference type="KEGG" id="sco:SCO4724"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4795"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_11"/>
    <dbReference type="InParanoid" id="Q7AKJ0"/>
    <dbReference type="OMA" id="HWEHSVA"/>
    <dbReference type="PhylomeDB" id="Q7AKJ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="29629" checksum="EA412DD27F9154CB" modified="2012-05-16" version="1">MVQIKNPEQIAKMREAGLVVAAIHAATREAAVPGATTKDLDQVARKVLAEHDAKPNFLGYGGFPATICTSVNEVVVHGIPSDDVVLKDGDVISIDCGAIIDGWHGDAAYTAFVGSGHSPELVELSRVTEESMWAGIAAMKQGNRLVDVSRAIETYIRRQPKPGGGKYGIIEDYGGHGIGTEMHMDPHLLNYVDRRRGKGPKLVPGFCLAIEPMVSLGTPRTEVLPDEWTVITTDGTWSSHWEHSVALTEQGPLVLTSPDGGKAKLAELGITAAPDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK5</accession>
    <name>Q8CJK5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7291</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAD55395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35317">
        <property type="entry name" value="T35317"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733728.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031569.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7291"/>
    <dbReference type="GeneID" id="1102729"/>
    <dbReference type="KEGG" id="sco:SCO7291"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7393"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="InParanoid" id="Q8CJK5"/>
    <dbReference type="OMA" id="VWRDDVE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="538" mass="56229" checksum="9468021FDC69849C" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJW4</accession>
    <name>Q8CJW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3500</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAD55321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36083">
        <property type="entry name" value="T36083"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733607.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029036.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3500"/>
    <dbReference type="GeneID" id="1098936"/>
    <dbReference type="KEGG" id="sco:SCO3500"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3558"/>
    <dbReference type="eggNOG" id="ENOG502ZAKK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025873_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJW4"/>
    <dbReference type="OMA" id="YWGYGTS"/>
    <dbReference type="PhylomeDB" id="Q8CJW4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD55321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="680" mass="75582" checksum="631B150D802EF81C" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK45</accession>
    <name>Q8CK45_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0790</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAD55278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733515.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978070.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CK45"/>
    <dbReference type="STRING" id="100226.SCO0790"/>
    <dbReference type="GeneID" id="1096213"/>
    <dbReference type="KEGG" id="sco:SCO0790"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.782"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_2_11"/>
    <dbReference type="InParanoid" id="Q8CK45"/>
    <dbReference type="OMA" id="WWEAFRQ"/>
    <dbReference type="PhylomeDB" id="Q8CK45"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD55278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="22847" checksum="22EAB66638BFD488" modified="2003-03-01" version="1">MQRAAVFDVDGTLVDTNHLHVTTWWEAFRQAGHRVPMHAVHRAVGLASGDLVARLLGEDRDKEQDAELSAAHKALYGQYFDRLPALPGAGDLLRRLAADGWTVVLATSAGGSELGALRRAIDADDAIEATASADDVDAGKPAPEPVEHALELAGVPAERAVFVGDTVWDMRAGSRAGVRCVGVLCGGLPRADLEEAGAEAVYADPADLLASLRGSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IV3</accession>
    <name>Q93IV3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1317</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625603.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977512.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1317"/>
    <dbReference type="GeneID" id="1096740"/>
    <dbReference type="KEGG" id="sco:SCO1317"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1320"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129851_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IV3"/>
    <dbReference type="OMA" id="VWTLRPN"/>
    <dbReference type="PhylomeDB" id="Q93IV3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15121" checksum="E3A583474BB315E2" modified="2001-12-01" version="1">MSIGELLAATVPMVRTLNLEYLETTPEKAVLALPDQSEYRNHVGGPHAGAMFTLGESASGAIVLAAFGDQLSRAVPLPVTAEIAFKKIALGPVTATATLGRPAAEVVAELDAGSRPEFPVSVAIRREDGAVTGEMTVIWTLRPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IW7</accession>
    <name>Q93IW7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625589.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027707.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1303"/>
    <dbReference type="GeneID" id="1096726"/>
    <dbReference type="KEGG" id="sco:SCO1303"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1305"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100610_0_0_11"/>
    <dbReference type="OMA" id="FETYAYA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="28268" checksum="7135DBCEA1676298" modified="2001-12-01" version="1">MRRARPCAPPRRRAYARLVLRIIDARTGEPAPAAPARRAPTRVEAHVPGHDATALRVLLVADLLVRVLELDSTPAWAVLTGAAERDGPRKDAAALGIRPFEDGTAGPGPGPGSGQSVRVVSEGEDAGEGEDEGGDEPGVATVAVASVHPAVPDLADPDAVRLALLERHHHAPVELDATALDEARATLAGLRGAVADWARQPSRPVPGELRDRLRAAWEDDLDAPGVLRVLRRVATDPDLPDGARFETFAYADRFLGLHLTRDVGSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J18</accession>
    <name>Q93J18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ribonuclease inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3989</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628172.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029361.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099425"/>
    <dbReference type="KEGG" id="sco:SCO3989"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4057"/>
    <dbReference type="eggNOG" id="COG2732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121832_3_0_11"/>
    <dbReference type="InParanoid" id="Q93J18"/>
    <dbReference type="OMA" id="ENWDAFW"/>
    <dbReference type="PhylomeDB" id="Q93J18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="89" mass="10228" checksum="68FEAB95BAE4C550" modified="2001-12-01" version="1">MITIDVSEVTDERTLHVLLKRELGFPDFYGMNWDAFWDSITGLVSIPTHVRFVGWDQLAAGVPRGAAMLRRALDDYQATYRPEFFAQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J23</accession>
    <name>Q93J23_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3984</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628167.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029356.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3984"/>
    <dbReference type="GeneID" id="1099420"/>
    <dbReference type="KEGG" id="sco:SCO3984"/>
    <dbReference type="HOGENOM" id="CLU_200600_0_0_11"/>
    <dbReference type="OMA" id="IGTHHAC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="7054" checksum="F55E8A16E8005067" modified="2001-12-01" version="1">MPPRQHLHVSETAAAAYRSTACRIGTHGACTEASASPAPVDLPVIYETCACPCHSAPDHSTRPAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA2</accession>
    <name>Q93JA2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7494</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631541.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031703.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102932"/>
    <dbReference type="KEGG" id="sco:SCO7494"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7606"/>
    <dbReference type="eggNOG" id="ENOG5031RGH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776424_0_0_11"/>
    <dbReference type="OMA" id="DCCERWW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176576" evidence="2">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="15783" checksum="88AAEE82DA0117E4" modified="2001-12-01" version="1">MTPSLRTARACRAAAALLVAAAVYAATRHSWLALPGLYVAAVFAWCAAREGAEHRRRVALARRAELLARPGQADPFAHGLEPCCAFWRHSDGVVHGPECGRPTAARVPLPEDCCERWWTSLGARHDAGCRRRTGAPGRGRARPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JH8</accession>
    <name>Q93JH8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1984</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626246.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028077.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1984"/>
    <dbReference type="GeneID" id="1097418"/>
    <dbReference type="KEGG" id="sco:SCO1984"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2010"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_11"/>
    <dbReference type="InParanoid" id="Q93JH8"/>
    <dbReference type="OMA" id="FCPVERL"/>
    <dbReference type="PhylomeDB" id="Q93JH8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="79"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="465" mass="49023" checksum="5EB9937B908D92DB" modified="2001-12-01" version="1">MTPSSPEPTGAAGHAGHAGPADLVISGCTVLVHDDRGRIGFEQDAAVVVRGGVVDSVTTAAAGASVPAADRIDARGQVALPGLINCHTHSPMVALRGLAEDLPTEEWFNDVVWPVESNLTGRDVMLGARLACAEMIRAGVTTFADSYFHMDAVAEVVDRCGMRAQLGQAYFSSQGPEGPAASLDFALRRRGFAGGRITTALAPHAPYTVVDADLAATAELARDHGLPVHLHAAENRDQTDTSLARHGVTPIGVLERTGVLDTDVLIAHGTGITEDDLPLLARAGGRTAVATAPRGYLKFGWPGTTPVRALRDIGVPVGLATDGAASNNSLDVWESMALTSLIQKSTEGDPRWLTSRQALHHATVQSARAVGLGDSVGRIAPGWRADLILVDLTGPHTQPVHDLAATLVHSARSADVRTTIVDGRVLMRDRELLTVDVSEVVRELGERLPALTDRGHGRRIQQYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RS6</accession>
    <name>Q93RS6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-08" db="PDB data bank">
            <title>The crystal structure of a homologue of telluride resistance protein (TerD), SCO6318 from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Xu X."/>
                <person name="Zheng Z."/>
                <person name="Savchenko A."/>
                <person name="Edwards A."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030820.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="PDB" id="2QZ7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=1-190"/>
    </dbReference>
    <dbReference type="PDBsum" id="2QZ7"/>
    <dbReference type="SMR" id="Q93RS6"/>
    <dbReference type="STRING" id="100226.SCO6318"/>
    <dbReference type="GeneID" id="1101759"/>
    <dbReference type="KEGG" id="sco:SCO6318"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6430"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1517049_0_0_11"/>
    <dbReference type="OMA" id="GAWEFRE"/>
    <dbReference type="PhylomeDB" id="Q93RS6"/>
    <dbReference type="EvolutionaryTrace" id="Q93RS6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2QZ7"/>
        </source>
    </evidence>
    <sequence length="190" mass="20881" checksum="E5477539CA0453BA" modified="2001-12-01" version="1">MSRRGLEREGGKPVSSDAKGLKRVDVRLKWDPSPWDRPPHHLDIIATTYAADAPHGRPVYVVQFDKRSPDGTINMSRHSRTGQGFGFVEEMTFELDRLSPSIARVIVGVAIHQDNGHKTFDDVSNTGVVVAEGYRELLTDGFERVAGATAATVAEFTRNASGAWEFREAVRGFDSDPVLFATEMGSAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD38</accession>
    <name>Q9AD38_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.112</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639685.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039411.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095190"/>
    <dbReference type="KEGG" id="sco:SCP1.112"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8061"/>
    <dbReference type="HOGENOM" id="CLU_1081489_0_0_11"/>
    <dbReference type="OMA" id="WYIATPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="28681" checksum="F76EBBBC5ECF5EA0" modified="2001-06-01" version="1">MARKPVTWYIATPADGIIEMSREAGTPVNLSANVGKVIDHPNPCRNKWYDESRFSYFRMVKRVGEALEDTGIWPITWPVPLWIVEPLGETGNWSQRHYPYRLLSHQIRVIEETDACPALGPCGRDVLNVVQQQIPEQAVRWAADWDADPEGMRQREWNWEQCGGRACASGRRAESVALTMSHARRESAAQTWIEHLARRAVDQALADTDASMYAYSYAYGRAIGHAVAAQHQTRFDAYVLDALRGTGLDSPASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD55</accession>
    <name>Q9AD55_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ordered locus">SCP1.95</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="15">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639668.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039394.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095173"/>
    <dbReference type="KEGG" id="sco:SCP1.95"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8043"/>
    <dbReference type="HOGENOM" id="CLU_106245_6_2_11"/>
    <dbReference type="OMA" id="WRMHAAC"/>
    <dbReference type="PhylomeDB" id="Q9AD55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC36616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="102" mass="11653" checksum="59CDF7ACDF54FC2C" modified="2001-06-01" version="1">MNRESIVRTHYAPDADLPVTTNWRARSACRTEDPDLFFPIGTTGPALHQIEEAKAVCRRCPVMEHCLRWALENGQEHGVWGGLDEGERRRMKRRAARQRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD74</accession>
    <name>Q9AD74_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629092.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029963.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4939"/>
    <dbReference type="GeneID" id="1100380"/>
    <dbReference type="KEGG" id="sco:SCO4939"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5019"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077388_0_0_11"/>
    <dbReference type="OMA" id="CGDTLWH"/>
    <dbReference type="PhylomeDB" id="Q9AD74"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28194" checksum="BC61C27874DB1332" modified="2001-06-01" version="1">MRVRRLGWAGLEIEAGGERMVIDYVRDLSPLFTGWKPGENVAVPGGRASAALVTHLHRDHTDASALSEVLTQGAPVLRPAPGHGDDVDNVTTLLAERELVRHRLAVEVVDVWSTRDLGPFRVTAVPAVDGLGDPQLNWVVEADGQRILHGGDTMFHGFWWLVARRFSPFDAVFLPANGAVVDAPHLQPPSPVPAALDPRQAAAAAEILDARFAVPIHYEPEQPDKIAGYVEVADPEAEFRAHAGRRAHVLAVGEWLDLAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-19" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK84</accession>
    <name>GCSP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvP</name>
        <name type="ordered locus">SCO1378</name>
        <name type="ORF">SC10A9.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625662.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027754.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9AK84"/>
    <dbReference type="SMR" id="Q9AK84"/>
    <dbReference type="STRING" id="100226.SCO1378"/>
    <dbReference type="GeneID" id="1096801"/>
    <dbReference type="KEGG" id="sco:SCO1378"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1386"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_2_1_11"/>
    <dbReference type="InParanoid" id="Q9AK84"/>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="PhylomeDB" id="Q9AK84"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166939" description="Glycine dehydrogenase (decarboxylating)">
        <location>
            <begin position="1"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <sequence length="961" mass="102809" checksum="7A9D905DD1E6D3D5" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWE0</accession>
    <name>Q9EWE0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4867</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629021.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029914.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4867"/>
    <dbReference type="GeneID" id="1100308"/>
    <dbReference type="KEGG" id="sco:SCO4867"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4945"/>
    <dbReference type="eggNOG" id="ENOG503488B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047403_0_0_11"/>
    <dbReference type="OMA" id="MGTKGAK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="393" mass="38982" checksum="FE418D9C9646979C" modified="2001-03-01" version="1">MADEQDKWLDRETAEFLLRGEPLEGADPAVRDRAERLLAALGALAPPVPAGEELPGEAAALAAFRKVRAEQADASAGVSAAVGHGAADRLSGAGPVRVGSRGEGARRPRRGRPLRLGLAAALTVGMIGGVAAAAGTGVLPTPFDRTEPEPAATVSAAASPGRPLAPPSPLDGVQGGSVPGATPGAPEGGTARDGGEAQDRGADDRNPGGSDGRRSSLAASCRKVRAGKELDTAHRHALKEAAGGASRVGKYCGALLAGTGTGGRDDTGRATPGGPVREGELRGDTGDGDGQGEKSDAGGKGGKGGKDGKDGKSDEGEGKGNGKGNGQGKDKGKGQGKGDDDGNGGDEDDAGIAPPRRGPHHPARPHHPDRAHGPHTSPAHRPQPQHTGAPHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF3</accession>
    <name>Q9EWF3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO4947</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629099.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029968.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4947"/>
    <dbReference type="GeneID" id="1100388"/>
    <dbReference type="KEGG" id="sco:SCO4947"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5027"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_11"/>
    <dbReference type="InParanoid" id="Q9EWF3"/>
    <dbReference type="OMA" id="GGHHNSV"/>
    <dbReference type="PhylomeDB" id="Q9EWF3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAD30933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135064" checksum="68FE936C17D4DB6F" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWL7</accession>
    <name>Q9EWL7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7773</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031899.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1103210"/>
    <dbReference type="KEGG" id="sco:SCO7773"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7889"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_13_3_11"/>
    <dbReference type="InParanoid" id="Q9EWL7"/>
    <dbReference type="OMA" id="HEESIYL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="19494" checksum="8E6484BED96C7F89" modified="2001-03-01" version="1">MNDLRFRLADDADLAAVVRLRDDAARWMLAQGVTGQWQPGELGEDHFRRIMKSGEVWLAEAADRVAGAWELWWEDEDAWGPQPPTAGYVHRLMVDRGSAPAGTGRQLLRVAERRVAEAGRPLVRLDCLATNARLSAYYLNAGYRVVGHKEGKRQPGGTPKSFTLLEKSVRDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWR8</accession>
    <name>Q9EWR8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0784</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625086.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027353.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0784"/>
    <dbReference type="GeneID" id="1096207"/>
    <dbReference type="KEGG" id="sco:SCO0784"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.776"/>
    <dbReference type="eggNOG" id="ENOG5031RMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094182_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWR8"/>
    <dbReference type="OMA" id="GTETHDR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="24447" checksum="C0CBF73F860F690D" modified="2001-03-01" version="1">MTTPVRKPTSPTETPTRRMPGWAKVLTALLLVLVVLFAGLRLSVVPGLKDLFGSETQDRSGPALLKSVQDISRYDAASGNFQVVVDLEKDAKFLPDAIRGTRTLYVGAGTVDAFVDLGKVDEEDVRVDDARTSATLRLPHAALGEPALDPDRSYAVSKQRGLLDRLGDLFSDNPNGEQAVQKLAARHIGDAAKDSELKARAESNTTAMLRGLLTSLGFEEVRVTYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWZ7</accession>
    <name>Q9EWZ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1129</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625422.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027595.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1129"/>
    <dbReference type="GeneID" id="1096552"/>
    <dbReference type="KEGG" id="sco:SCO1129"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1126"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWZ7"/>
    <dbReference type="OMA" id="YESITMQ"/>
    <dbReference type="PhylomeDB" id="Q9EWZ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="58"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC13081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="29784" checksum="8401D34231569321" modified="2001-03-01" version="1">MNRPEAPRTRHGFPTGRAVYAVAPVVAAALAHIGPAATWLPELRRRRFPGLAGRGSPGHVALTFDDGPDPASTPRFLDTLDGLGVRATFFVLGENALRHPALTRELVRRGHELAVHGWTHDRPWWPSPARDTRELLRAVRVVDEVSGRAPRWYRPPYGILTSGRWAAARRAGLRPVLWTAWGKDWRHDATPASVRATVAADLCGGGTVLLHDTDHASAPGSWRATLGALPDIVRDCREAGLAVGPLGEHGAGGATGTPGTAAVAGTAGTAGTAASFRSPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX21</accession>
    <name>Q9EX21_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1019</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625315.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027523.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1019"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1096442"/>
    <dbReference type="KEGG" id="sco:SCO1019"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1014"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_2_0_11"/>
    <dbReference type="InParanoid" id="Q9EX21"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="PhylomeDB" id="Q9EX21"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="54"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="411" mass="44156" checksum="BFB42FA81821BFEE" modified="2001-03-01" version="1">MSADAWTSVVTVVTLVSALSLAAWLWLLLARGFFWRTDVRLPAREEPDDWPSVCVVVPARDEAAVLPASLPSLLAQDYPGRAEVFLIDDGSTDGTGGLACELARRHEGLPLTVASPGEPPAGWTGKLWAVRHGIGLARAREPEYLLLTDADIAHAPDSLRALVSAAGTGGFDVVSQMARLRVESVWERLVVPAFVYFFAQLYPFRWIGGGRAGSGRGRATRTAAAAGGCVLLRADAAERARIPDAIRHAVIDDVALARAVKGTGGRVWLGLADRVDSVRPYPRLHDLWRMVSRSAYAQLRHNPLVLAGTVLGLALVYLVPPAAVLVGAATGQGTTAALGAAAWLVMAGTYLPMLRYYRQPLWLAPLLPFTAFLYLLMTVDSAVQHYRGRGAAWKGRTYARPDAVPEEGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2R1</accession>
    <name>Q9F2R1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4478</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628644.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029683.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4478"/>
    <dbReference type="GeneID" id="1099918"/>
    <dbReference type="KEGG" id="sco:SCO4478"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4548"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122293_0_0_11"/>
    <dbReference type="OMA" id="IFADAWP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="21554" checksum="DD7D24A46C83208D" modified="2001-03-01" version="1">MPGMSLQGTDAHRNADGTLPALVARAVAAARAHGFPYSCRPEQGRLLRLLAGGAPRGIAETGTGCGVGLAWLASGAPPGTRLVSVERDAERVRVARQVFRDHPEVGILHGDWRRVEEHGPYDLLVLDGGGQAKGDGTADPVRLLTPGGTLVVDDFTPATTWPPLFGGVPDRPRLHWLEHPALRTTELRLAPDLAVIVGTRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2X2</accession>
    <name>Q9F2X2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aminopeptidase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4589</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628751.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029747.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="M28.003"/>
    <dbReference type="GeneID" id="1100029"/>
    <dbReference type="KEGG" id="sco:SCO4589"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4661"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F2X2"/>
    <dbReference type="OMA" id="DHASFKN"/>
    <dbReference type="PhylomeDB" id="Q9F2X2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176668" evidence="3">
        <location>
            <begin position="30"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="113"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC08290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="33594" checksum="53BB08E87F299389" modified="2001-03-01" version="1">MQLLPSGRALTAGAVAVVTLMAGGSAAGAASAPVHPATPTGTAAAAAAPDIPIANVKAHLRQLESIATANGGNRAHGRAGYRASLDYMKAKLDAAGFTTRVQQFSASGRTGYNLTADWPGGDASQIVMAGSHLDSVASGPGINDNGSGSSAVLETALAVARSGYQPTKHLRFAWWGAEELGLVGSRYYVNSLGSAERAKISGYLNFDMIGSPNPGYFVYDDDPTIEKTFKDYFSGIGISTEIETEGDGRSDHAPFKNAGVPVGGLFSGADYRKTSAQAAKWGGTVGQPFDRCYHSSCDTTANIDDTALDRNSDAIAYAVWELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F380</accession>
    <name>Q9F380_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4408</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628576.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029636.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4408"/>
    <dbReference type="GeneID" id="1099848"/>
    <dbReference type="KEGG" id="sco:SCO4408"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4476"/>
    <dbReference type="eggNOG" id="ENOG50337WN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034291_0_0_11"/>
    <dbReference type="OMA" id="RAFECWV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="149"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="428" mass="44745" checksum="B11E72F8D98925AD" modified="2001-03-01" version="1">MTAYDENGENGQNDETGESDDGGTGTGTGTGTGTGTGARIPLPRASVEDGGRALPEAAPVALEHQVLTSLLGAWALAACSAPEAAAVEEHLGECDSCADEALRLREAVTLLQRPESLDLDPALRTRVLEGCLERRPPRIPVPEWAASYDAETARLDALLQDFGDAEWHAPVRLRWFEDDGAASRRTTVAGVIAHLLTVDGTVAVGLGLDDPLGDITAPSGGPAARTEAYWRASHYPPTRAVRAPWREQSHSIVRTVAFTGDAGGMPVSYGDFELPLRDAMLDRAFECWVHAEDIAEAVDYPYAPPSARHLNGMIDLAARMLPGVLAARRRAGLATPGGGPHLVAAGGPGRSLRLEIEGSGGGEWLIPLDSPGAVGSADHEVAHVALDGVEFCRLAAGHVPPAEAAAGQAGDREAIRDVLFAAAGLSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3C6</accession>
    <name>Q9F3C6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7549</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631592.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971596.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7549"/>
    <dbReference type="GeneID" id="1102987"/>
    <dbReference type="KEGG" id="sco:SCO7549"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7663"/>
    <dbReference type="eggNOG" id="ENOG50329BU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093861_2_0_11"/>
    <dbReference type="OMA" id="NNFADSP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="13162" checksum="A3A4025402F6752A" modified="2001-03-01" version="1">MYDQTRAQQPSDQDQRRTGHRPAAPEALLPPAERDAVLDRLRKAINTFADAPHEALEEAEGAFDDAAAHLASALAERRRALRERWREQDPETHAEELRIALRQYREITQRLIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3H8</accession>
    <name>Q9F3H8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2803</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627033.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028594.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2803"/>
    <dbReference type="GeneID" id="1098237"/>
    <dbReference type="KEGG" id="sco:SCO2803"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2861"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068637_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F3H8"/>
    <dbReference type="OMA" id="LSFEYQR"/>
    <dbReference type="PhylomeDB" id="Q9F3H8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC10112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="289" mass="30586" checksum="5FBBAD17B2A49E8D" modified="2001-03-01" version="1">MGKSRNARRGRAAAEAVVEDVDGGRAELVPDRDRPRAWTLLIDGAPQSHVDLDDPAYLSFEYQRRIGHVIDLTAPPGRPLRAVHLGGGALTLARYVAATRPRSTQQVVERDAALVQLVRRELPLDPGARIRVRSTDARAGLAKVPDGWADLVVADVFGGARTPAHLTSTEFLDEVRRALAPGGVYAANLADGPPLAHLRGQIATAAARFAALALVADPAVLRGRRFGNAILVAADHPLPVAELTRRAASDPHPARVEHGRALTDFAGGAHPVTDAAAVDSPAPPESVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3P7</accession>
    <name>Q9F3P7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7640</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631680.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031796.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7640"/>
    <dbReference type="GeneID" id="1103078"/>
    <dbReference type="KEGG" id="sco:SCO7640"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7760"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="InParanoid" id="Q9F3P7"/>
    <dbReference type="OMA" id="DEHRLKC"/>
    <dbReference type="PhylomeDB" id="Q9F3P7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC16973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="34410" checksum="7D692F1C084501BF" modified="2001-03-01" version="1">MDLTVWRTFVTVCRLGSLSAAADELNHTQSAVSRQIAGLERQLGVPLVERHARGVRPTPAGEVFRRHALTTLTEADRAVRAARDVRDGGSGRPLAVGAVPSLASGIVPEAVRGLLDRAGHIRWSLVPGLTGQLHRRVIGGDIDLAVVTDAPPGLPHAPQVERRFLGLDRMVVVLPADHPRAGAGPVHIRTLADETWAEDNDGSAALLRRHAARAGVGVRIDLGAADLPGKLALVATGHAIALVPGVLRRALRADVTTVGLVDAPTRGVYTITPYRDPHPCAAPLHDELTSAFAAVGEPMATSPVAAREAVAAGESEEAQQELRTQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC23</accession>
    <name>Q9FC23_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative marR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631123.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972083.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7061"/>
    <dbReference type="GeneID" id="1102499"/>
    <dbReference type="KEGG" id="sco:SCO7061"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7165"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="InParanoid" id="Q9FC23"/>
    <dbReference type="OMA" id="QREMTVF"/>
    <dbReference type="PhylomeDB" id="Q9FC23"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="19954" checksum="3515F69AA48CBD40" modified="2001-03-01" version="1">MTAAETPDETTVVPGGCPADAAVETIQREMTVFARRARASAGRMHPELSLVSYTLLGHLEERDGRRATDLAAHYALDKSTVSRQVSALERAGLIERRVDPDDHRVQVLHLTESGRDVLDRVTERRRAAFRERLADWPEEELLRFAAYLERYNAWPDAAPGAERDRAAAADTYGWTSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCG0</accession>
    <name>Q9FCG0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4210</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628385.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029502.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4210"/>
    <dbReference type="GeneID" id="1099650"/>
    <dbReference type="KEGG" id="sco:SCO4210"/>
    <dbReference type="eggNOG" id="ENOG503494T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142296_0_0_11"/>
    <dbReference type="OMA" id="WIEDHRE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046003">
        <property type="entry name" value="DUF5959"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19384">
        <property type="entry name" value="DUF5959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17911" checksum="9B382295520685F3" modified="2001-03-01" version="1">MESTDGVINLIHLADAPGTSGHSVSVRVLGRFQPGILTGHDFLDCEIAIVAESLSATFPVTLLPEDLEDWEDALAALGSGRFAMWLESGRTPSMKFKPDESGGLWVSVHDGPASGVTVTVPLFVLSSAWVDEQRDLLTRVREVYPREVVETSPGAYEWRRDTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCG4</accession>
    <name>Q9FCG4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4205</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628380.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974766.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4205"/>
    <dbReference type="GeneID" id="1099645"/>
    <dbReference type="KEGG" id="sco:SCO4205"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4269"/>
    <dbReference type="eggNOG" id="ENOG5032T7B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111492_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCG4"/>
    <dbReference type="OMA" id="IRKEYAW"/>
    <dbReference type="PhylomeDB" id="Q9FCG4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="18730" checksum="F9070A4C49A81257" modified="2001-03-01" version="1">MAEAPQQKAAQALEEALKDAELEWESPESGTYVVKLPGTRKLSTTVSLRLGRHSLSLNAFVVRHPDENEPAVHRWLLERNLKLYGIGYAVDRLGDIYVTAKLSLAAVTPDEIDRLLGQVLEAADGAFNTLLELGFASAIRKEYEWRTARGESTRNLEAFQHLIERSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL3</accession>
    <name>Q9FCL3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7801</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631832.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031925.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7801"/>
    <dbReference type="GeneID" id="1103239"/>
    <dbReference type="KEGG" id="sco:SCO7801"/>
    <dbReference type="eggNOG" id="ENOG5032EDV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002686_0_0_11"/>
    <dbReference type="OMA" id="MFWSAAN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13812" checksum="7FD8BB985CC94B47" modified="2001-03-01" version="1">MALILLLAAPVVIGMPTALVWLLGRRAKVPSWMLIVFLLAGWLTVSVGWALSQRAQPSLFPETSPCYGTRDTPVSQYFPPDSFCRHADGELRTVNGANSKLMFWSAANTTLAVVIAAALVRRRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCM2</accession>
    <name>Q9FCM2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7792</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631823.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031916.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7792"/>
    <dbReference type="GeneID" id="1103230"/>
    <dbReference type="KEGG" id="sco:SCO7792"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7909"/>
    <dbReference type="HOGENOM" id="CLU_2221649_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="106" mass="10872" checksum="261523428DC7AEEE" modified="2001-03-01" version="1">MGTLPVLDATGCRAALPRRGHWLSGRSGVIAAARHPEALGRLRDAGATTVSPAQDGPDALEQALADAMSETSPGLVLDCLWGPVTKAYFAALRRSGGNTGANTPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J0</accession>
    <name>Q9K3J0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycine betaine ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4830</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628986.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029893.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4830"/>
    <dbReference type="GeneID" id="1100271"/>
    <dbReference type="KEGG" id="sco:SCO4830"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4906"/>
    <dbReference type="eggNOG" id="COG4175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_2_2_11"/>
    <dbReference type="InParanoid" id="Q9K3J0"/>
    <dbReference type="OMA" id="RRDMQEE"/>
    <dbReference type="PhylomeDB" id="Q9K3J0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005892">
        <property type="entry name" value="Gly-betaine_transp_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01186">
        <property type="entry name" value="proV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="48"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="80"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB97433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="394" mass="42133" checksum="A2264A9297109227" modified="2000-10-01" version="1">MSTTGKNTTAAATDTVTERPPVFSVDGLWKVFGPKAARVPADPDLTALSPAELRSRTGCTAAVADVSFDVRKGEVFVVMGLSGSGKSTLVRCLTRLIEPTAGSIVIDGEDVRAMDRSRLRELRRHRAAMVFQHFGLLPHRTVLDNVAYGLEVQGMGRAERRERAAAIVAKVGLEGLEQRRPGQLSGGQRQRVGLARALAVDPEVLLFDEPFSALDPLIRRDMQEEVVRLHREEGRTMVFITHDLQEALKLGDRIALMRDGRVVQLGTPEEIVGSPADDYVREFVRDVPREQVLTVRTAMRPAANADEAGTGPAIRPEATVSEAIEAVARAGSAARVMSDGRCLGVVDAADLLSVVAGTAAAGSRAAGAARVGAAATGERREPTDPRPATTEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3W0</accession>
    <name>Q9K3W0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4384</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628553.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974599.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4384"/>
    <dbReference type="GeneID" id="1099824"/>
    <dbReference type="KEGG" id="sco:SCO4384"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4452"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="InParanoid" id="Q9K3W0"/>
    <dbReference type="OMA" id="LNWMRAM"/>
    <dbReference type="PhylomeDB" id="Q9K3W0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="25857" checksum="ABB55C579F4128BE" modified="2000-10-01" version="1">MTPPAHVDRTRARGVETLTLDSPHNRNALSAALVDGLAAALTAAGDDPGVRAVVLTHTGNTFSAGADLRDPPDPDALVGLFRRIIELPKPVIARVAGHVRAGGLGLVAACDIAAASTESTFAFTEVRIGVAPAVISLTLLPRADPRALARHYLTGERFDAAEAARAGLVTAAGDDVDAVLEPVLDGVRRAAPQGLAETKRLLTARVLEAFDRDAADLTALSARLFASPQAREGMTAFLERRDPEWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Y9</accession>
    <name>Q9K3Y9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative solute binding transport lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1344</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625629.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977483.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1344"/>
    <dbReference type="GeneID" id="1096767"/>
    <dbReference type="KEGG" id="sco:SCO1344"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1351"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_2_11"/>
    <dbReference type="InParanoid" id="Q9K3Y9"/>
    <dbReference type="OMA" id="GRGWFPD"/>
    <dbReference type="PhylomeDB" id="Q9K3Y9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004332370" evidence="1">
        <location>
            <begin position="31"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="58640" checksum="75FB0572B54EF28E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K411</accession>
    <name>Q9K411_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1322</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625607.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1322"/>
    <dbReference type="GeneID" id="1096745"/>
    <dbReference type="KEGG" id="sco:SCO1322"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1325"/>
    <dbReference type="eggNOG" id="COG4912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924118_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="31669" checksum="1322B81BECD17A6D" modified="2000-10-01" version="1">MSVTARPIPDAPHSALADTVLERITLEYPAAADPERAVGLRAYMKDVAPFLGMTSPVRRSLSRAVLAGVPRPDEPDCTAVALRCWRLPEREYHYFAVDYLRRYVTHCSSGFLPVVRHLLTTVPWWDTVDLLAAHVVGAWSPPTAASRPTWTPGSMTRTAGWSARPSSTSCGTRNAPTPTGSSATACAGPATATSSSARPSAGACASTPGPTRTPCAPSWPSTAPASRRCPRGRRCGPSARSAGAVPLSNGRSIKNHSTCDEASAMICLMFRYAFHLAASAVADAPKAAVAHFTAAVDGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K435</accession>
    <name>Q9K435_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1064</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625358.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977766.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1064"/>
    <dbReference type="GeneID" id="1096487"/>
    <dbReference type="KEGG" id="sco:SCO1064"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1061"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="InParanoid" id="Q9K435"/>
    <dbReference type="OMA" id="QVWIVAF"/>
    <dbReference type="PhylomeDB" id="Q9K435"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="34174" checksum="E1BE00DEE3BB1422" modified="2000-10-01" version="1">MTSGTLTPPRKERAAPDAPRPARRSRRKPFLAPYLFVAPFYVVFAAFGLYPLVFALQLSFTDWKGAGEANFIGLENYTYLLTSEEFWSSLGNSAVMWLLIVPLQIVGGLAAAVLLANAKLRLRGMFRVAFIAPFVTPLVAMAQVWIVAFDTDYGLVNHLFNFVGLPDVDWLQSTVWAKPTLALLFLWKTTGFAIIILLAGLQAVPGDVYEAAALDGASRKRQFWSLTLPLVRRSIAFLVVVQTLAVFQMFAEPFVVTQGGPYGSTTTGGLYLYNHILASDLGTGAANSFLLVLLVFALSLLSVRLLRSRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K443</accession>
    <name>Q9K443_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar transport sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1056</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625350.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027548.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1056"/>
    <dbReference type="GeneID" id="1096479"/>
    <dbReference type="KEGG" id="sco:SCO1056"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1053"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="InParanoid" id="Q9K443"/>
    <dbReference type="OMA" id="SEMPTFA"/>
    <dbReference type="PhylomeDB" id="Q9K443"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004332378" evidence="1">
        <location>
            <begin position="37"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="419" mass="44546" checksum="B16622CDE5F8E791" modified="2000-10-01" version="1">MTAHPPAAARRGRGRSRRVVAPFTAVSVLVAGAALAGCGQQRDADTYTVMNSSTDESYHRWDAEAMARCGKELGVTIEQQSVPAAQVMTKALRMASSKSLPDIVQFDASEMPTFADAGGLVDLRTLGLSTDDIPDGIVDFGSYKGTYYGAARSVNTLALFYNKDVLDQAGVEVPTTWAELRATAQKLTRGKQYGLALSAGGAEDGVFQFTPFMWSNGGDETDLDGPKVVEALDYWKDLLKDRSLSKSTVNWTQADVNDQFMAGNAAMMINGPWQVETLNSDTSLHWGIAPIPVPRAGDDSVGPLGGAVLTVPNTGDEAREKTAGKIVACLASEKEQLTYALNSWMVPANAKAAAVWREKVPELDSLADQVAVARSRTAKLGAGWSSVSLALQSAFQSALTGQSSETALKRAQQRATSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K465</accession>
    <name>Q9K465_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631276.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031520.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7220"/>
    <dbReference type="GeneID" id="1102658"/>
    <dbReference type="KEGG" id="sco:SCO7220"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7319"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_3_11"/>
    <dbReference type="InParanoid" id="Q9K465"/>
    <dbReference type="OMA" id="HQREHTQ"/>
    <dbReference type="PhylomeDB" id="Q9K465"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="314"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="667" mass="71208" checksum="CF1A4DE51D82F7ED" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K471</accession>
    <name>Q9K471_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7214</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631270.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031515.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7214"/>
    <dbReference type="GeneID" id="1102652"/>
    <dbReference type="KEGG" id="sco:SCO7214"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7313"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045983_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K471"/>
    <dbReference type="OMA" id="SWTIGGY"/>
    <dbReference type="PhylomeDB" id="Q9K471"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="36283" checksum="F87B72556AB869B2" modified="2000-10-01" version="1">MTGATGGPAAVEGGAREELRDAITLRAALIMLGVLLLQLGFALSYMGAFHAPRPHDVPITLVAPPEMRGDLAARLDALPGDPLRVTAVADAAEARARLLDRRTDAALLVAPDARLDTLLVASAGGPSATTAATAVLQDVARTQDREIQVRDLRPPSAGDSRGLSSFYLVLSWTIGGYLAASALNMAAGSKRPTLHRTFVRLAAMIPYAFVSGIGGAVVVGPVLDCLPGAFWELVGIGTLVVFASGAVGVALQSVAGTIGLGLTILIFTVLGNPSSGGVYPASLLPPFWAAIGQALPPGAGTTVVRNTVYFDGHATTGALWILGAWALGGVVVAVLAAALRARRRPRAVATTAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4G9</accession>
    <name>Q9K4G9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4169</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628345.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029480.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4169"/>
    <dbReference type="GeneID" id="1099609"/>
    <dbReference type="KEGG" id="sco:SCO4169"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4234"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K4G9"/>
    <dbReference type="OMA" id="GMTYTPM"/>
    <dbReference type="PhylomeDB" id="Q9K4G9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="26132" checksum="A372F691F1B88672" modified="2000-10-01" version="1">MHDLTGKNVIITGGARGLGAEAARQAVAAGAHVLITDVLDDDGENAARELGDRARFLHHDVTSEEDWSRAADFAVTEFGALHGLVNNAGISTGTPLESESVDHFRKVLDVNLTGVFIGMKTVVPALKEAGGGSIVNISSAAGLMGLALTAGYGASKWGVRGLTKIGAVEWGTARVRVNSVHPGMTYTPMTAAVGIERGEGKYPNTPMGRVGEADEIAGAVVFLLSDAASYVTGAELAVDGGWTTGPTVAYVMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK4</accession>
    <name>Q9KXK4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2316</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028275.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2316"/>
    <dbReference type="GeneID" id="1097750"/>
    <dbReference type="KEGG" id="sco:SCO2316"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2353"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764792_0_0_11"/>
    <dbReference type="OMA" id="MDWYYPV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB93436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="365" mass="40322" checksum="3821481CABD98096" modified="2000-10-01" version="1">MTAPRTPGTPRTPRTEHLVLPGVLTAAEAAATVRGILAVQREDGAIPWFRGHHLDPWDHVEAAMALDTADEHEAAERAYAWLARHQNQDGSWYAAYADGDFADVTDRGRETNFVAYVAVGVWHHYLATGDDLFLERMWPVVHAAVEFVLRLQQPGGQIGWRRGDDGTDTTDALLTGSSSVHHALRCALAIAEQREEPQPDWELAAGALRHAIRRHPERFLDKGRYSMDWYYPVLGGALTGTEARSRIQESWDRFVVPGLGVRCVVPNPWVTGGESAELALALWAVGESDHALEILQSIQHLRDPDSGLYWTGYVFEDETVWPRELTAWTAGSLLLAVAALGGHEATCQVFAGERLPRGLDPDCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYA6</accession>
    <name>Q9KYA6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6927</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630994.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031309.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6927"/>
    <dbReference type="GeneID" id="1102365"/>
    <dbReference type="KEGG" id="sco:SCO6927"/>
    <dbReference type="eggNOG" id="ENOG5033RYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_752091_0_0_11"/>
    <dbReference type="OMA" id="LCWQHIN"/>
    <dbReference type="PhylomeDB" id="Q9KYA6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="374" mass="40738" checksum="CC915AF1E97DAECF" modified="2000-10-01" version="1">MDVGQIAKRFPLVARPRPACLPLAERVREITDLAAAAERDGNVTSATVALNKAALIASDCGMPDLARTLCWRHAEAVLRAQPLGAQEARYALEPLVNLARLRIRDGDGHGAYHLLDSLNRAVRSKTEAVIDGRTTPLQHLTTSAADHQQVCQWLWTVLLGDGTRALVAAGEWDRARAHSRQHRGIGQRLFDGRQVEVLVRCLGEQPSDALMFLHTSQLVEPWEQSVAAALTVLCHRAADEHPVEPVDKMVQHYLALDSAPELAVFRSRVGLVVLDLSPKTRQAEAMRRLTCEAMRQTDGYVARDVLAHPVCREALGHGEHRTLSAAVASAGLGQGHIPEPLTQALLGAASVSADVWERHVTRRASPGSSRNLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYA7</accession>
    <name>Q9KYA7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6926</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630993.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031308.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6926"/>
    <dbReference type="GeneID" id="1102364"/>
    <dbReference type="KEGG" id="sco:SCO6926"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7032"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_2_2_11"/>
    <dbReference type="OMA" id="WEDSCAR"/>
    <dbReference type="PhylomeDB" id="Q9KYA7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="107"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="30104" checksum="53C353F2C244F29E" modified="2000-10-01" version="1">MCGAIKDGGGEGESTGIGALLRVFRAAAGTTLGRPILQREVADALHRSERWYRDLEGGVITRPLTRHELDTIGTLLGLDRVQRRALFLVSNGGGLSSPETQEPPRISDELRLLLDQQPFPAYVIDATWNVLAVNTSMAALFPWSTAPGANLMRWLLLSAEARDQHLHWEADAEVCVCMLRDAAVDRPHDPDLQQLISDSRQNPAVRDLWTRGAADFADHYDGHVLQMTLPLFDGQVTELVTHVLQPAGLPGCRMTILTQRAPQEPSGRQPVQAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYG7</accession>
    <name>CHPF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaplin-F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chaplin-G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">chpF</name>
        <name evidence="12" type="synonym">chpG</name>
        <name type="ordered locus">SCO2705</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1714" last="1726">
            <title>A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Rink R."/>
                <person name="de Jong W."/>
                <person name="Siebring J."/>
                <person name="de Vreugd P."/>
                <person name="Boersma F.G."/>
                <person name="Dijkhuizen L."/>
                <person name="Wosten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="12832396"/>
            <dbReference type="DOI" id="10.1101/gad.264303"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1727" last="1740">
            <title>The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Elliot M.A."/>
                <person name="Karoonuthaisiri N."/>
                <person name="Huang J."/>
                <person name="Bibb M.J."/>
                <person name="Cohen S.N."/>
                <person name="Kao C.M."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12832397"/>
            <dbReference type="DOI" id="10.1101/gad.264403"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="433" last="443">
            <title>The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Stokroos I."/>
                <person name="Deelstra H.J."/>
                <person name="Penninga N.A."/>
                <person name="Bormann C."/>
                <person name="Salas J.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Woesten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="15228525"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04143.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="64" first="602" last="613">
            <title>SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Capstick D.S."/>
                <person name="Willey J.M."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="17462011"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2007.05674.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="1128" last="1140">
            <title>Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose.</title>
            <authorList>
                <person name="de Jong W."/>
                <person name="Woesten H.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Claessen D."/>
            </authorList>
            <dbReference type="PubMed" id="19682261"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06838.x"/>
        </citation>
        <scope>FUNCTION IN GROWTH SUBSTRATE ATTACHMENT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E18839" last="E18839">
            <title>The assembly of individual chaplin peptides from Streptomyces coelicolor into functional amyloid fibrils.</title>
            <authorList>
                <person name="Sawyer E.B."/>
                <person name="Claessen D."/>
                <person name="Haas M."/>
                <person name="Hurgobin B."/>
                <person name="Gras S.L."/>
            </authorList>
            <dbReference type="PubMed" id="21526199"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0018839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISULFIDE BOND</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="J. Struct. Biol." volume="184" first="301" last="309">
            <title>Chaplins of Streptomyces coelicolor self-assemble into two distinct functional amyloids.</title>
            <authorList>
                <person name="Bokhove M."/>
                <person name="Claessen D."/>
                <person name="de Jong W."/>
                <person name="Dijkhuizen L."/>
                <person name="Boekema E.J."/>
                <person name="Oostergetel G.T."/>
            </authorList>
            <dbReference type="PubMed" id="24012833"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2013.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="4491" last="4501">
            <title>Surface modification using interfacial assembly of the Streptomyces chaplin proteins.</title>
            <authorList>
                <person name="Ekkers D.M."/>
                <person name="Claessen D."/>
                <person name="Galli F."/>
                <person name="Stamhuis E."/>
            </authorList>
            <dbReference type="PubMed" id="24413917"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5463-z"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2017" name="Biomolecules" volume="7" first="0" last="0">
            <title>Structure-dependent interfacial properties of chaplin F from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Dokouhaki M."/>
                <person name="Prime E.L."/>
                <person name="Hung A."/>
                <person name="Qiao G.G."/>
                <person name="Day L."/>
                <person name="Gras S.L."/>
            </authorList>
            <dbReference type="PubMed" id="28925983"/>
            <dbReference type="DOI" id="10.3390/biom7030068"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 6 7 8 10">One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins (PubMed:12832396, PubMed:12832397, PubMed:15228525, PubMed:17462011). Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation (PubMed:17462011). Chaplins are also involved in cell attachment to a hydrophobic surface (PubMed:19682261). Forms amyloid fibrils in vitro probably composed of stacked beta-sheets, at low extracellular concentrations individually restores the ability to form aerial hyphae to a chaplin-deficient strain (PubMed:21526199). A small chaplin extract (ChpD, ChpE, ChpF, ChpG and ChpH) self-assembles into 2 different amyloids; small fibrils at the air-water interface form an amphipathic membrane that resembles spore-surface structures involved in aerial hyphae formation, and hydrophilic fibrils in solution that resemble the fibers that attach cells to a hydrophobic surface. At the air-water interface the hydrophilic surface is in contact with water (probably equivalent to the peptidoglycan layer), while the hydrophobic face is exposed to the air, making the surface of the aerial hyphae hydrophobic (PubMed:24012833). A small chaplin extract applied to a chaplin-deficient strain restores aerial hyphae formation (PubMed:12832396, PubMed:12832397). The small chaplin extract forms an amyloid-like structure similar to that seen on the surface of cells without rodlets (rdlA-rdlB deletions), and is highly surface active, reducing surface tension from 72 to 26 mJ/m(2), which probably allows escape of hyphae from an aqueous environment into air (PubMed:12832396). ChpF alone is less surface active at pH 3.0 than at pH 10.0, it reduces the surface tension of water from 72.8 mN/m to 50 mN/m at pH 3.0 or to 37 mN/m at pH 10.0 (PubMed:28925983). ChpF and ChpG are sufficient to restore the rodlet layer and hydrophobicity to a strain deleted for the other 6 chaplin genes (PubMed:15228525).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer; disulfide linked. About 20% of ChpF isolated from cell wall forms disulfide-bonded homodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3 14">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 3 7">Secreted</location>
            <location evidence="2 3 7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Fimbrium</location>
        </subcellularLocation>
        <text evidence="6">Considerably more ChpF is seen in fimbrae than in aerial hyphae.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2 14">Present in aerial hyphae of sporulating cultures (at protein level).</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3 5">Not expressed while still submerged, accumulates during aerial hyphae formation on minimal medium, no transcript detected during sporulation (PubMed:12832396). During aerial hyphae formation and early sporulation on rich medium, under control of ECF sigma factor BldN (PubMed:12832397). Expression depends on bldB but not bldA, bldD or bldH (at protein level) (PubMed:17462011).</text>
    </comment>
    <comment type="domain">
        <text evidence="10 15">The mature protein rapidly forms a predominantly amyloid fibril beta-sheet structure at pH 3.0 and 4.2, with less beta-sheet and more random coil at pH 10 (Probable) (PubMed:28925983). Reduced and non-reduced peptide have the same secondary structures at all pH tested, suggesting the disulfide bond is not required for fibril formation (PubMed:28925983).</text>
    </comment>
    <comment type="mass spectrometry" mass="5182.0" method="MALDI" evidence="2"/>
    <comment type="mass spectrometry" mass="5177.48" method="MALDI" evidence="3"/>
    <comment type="disruption phenotype">
        <text evidence="4 5 6">A strain deleted of chpF and chpG makes rodlets (PubMed:15228525). Deletion of all 8 chaplin genes on minimal medium leads to severely disrupted aerial hyphae that collapse on the colony surface and are not hydrophobic. A few spore chains can still be made, but they have neither rodlets or amyloid-like fibers. rdlA and rdlB mRNA are down-regulated (PubMed:15228525, PubMed:17462011). Deletion of all 8 chaplin genes on rich medium leads to a reduced abundance of aerial hyphae without rodlets and occasional spore chains on surface hyphae. A complete chaplin-negative plus ram-negative strain (deletion of ramR or the ramC-ramS-ramA-ramB operon) leads to the complete loss of robust aerial hyphae (PubMed:17462011). Deletion of all 8 chaplin genes significantly reduces cellular attachment to a hydrophobic substrate; thin fibrils instead of fimbrae are detected. The long chaplins (ChpA, ChpB and ChpC, as seen by near wild-type attachment of the hextuple chpA-chpB-chpC-chpD-chpE-chpH knockout) are not essential but may contribute to attachment (PubMed:19682261).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="9">The small chaplin mixture (a cell wall extract of an rdlA-rdlB knockout) forms a stable coat on a number of surfaces (including Teflon and cotton) and emulsifies oil-water mixtures, which could be useful in medical and technical applications.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the chaplin family. Short chaplin subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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    <dbReference type="STRING" id="100226.SCO2705"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0034">Amyloid</keyword>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0281">Fimbrium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2 3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329169" description="Chaplin-F">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
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    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15228525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19682261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="24012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="24413917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="28925983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="88" mass="8698" checksum="D0AEB6579BD330D9" modified="2000-10-01" version="1" precursor="true">MYNPKEHFSMSRIAKGLALTSVAAAAVAGTAGVAAADSGAQAAAAHSPGVLSGNVVQVPVHIPVNVCGNTIDVIGLLNPAFGNECEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ77</accession>
    <name>Q9KZ77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chlorohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3071</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627291.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
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    <dbReference type="KEGG" id="sco:SCO3071"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3131"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_3_1_11"/>
    <dbReference type="InParanoid" id="Q9KZ77"/>
    <dbReference type="OMA" id="MCPTTER"/>
    <dbReference type="PhylomeDB" id="Q9KZ77"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidohydro-rel"/>
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    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="449" mass="47602" checksum="299C93A6F9BF751B" modified="2000-10-01" version="1">MTSSEQPRTYWLEHAWLGTHVEPGVALDVRDGRITAVNQGVATPPPGAGILRGLTLPGLANAHSHAFHRALRGTVQVGSGTFWTWREVMYSVADRLTPDTYHALARAVYAEMALAGITAVGEFHYVHHAPGGTPYADPNAMGEALIEAAAEAGVRITLLDTCYLSSGFGEPPNTHQRRFSDGTADAWAERCSVLKERDHARIGAAIHSVRAVPADQLATVAQWAEERRAPLHVHLSEQTAENDACRQAHGRTPTRLLADHGVLGARTTGVHNTHLTDEDIALLGGSRTGTCMCLTTERDLADGIGPAAALQRAGSPLSLGSDSHAVVDLLEEARAMELNERLRTRARGHWTAAALLRAATADGHAALGWDDTGRIEAGARADLATIALDSVRTAGPLPRLGAETAVFAATAADVRHTVVGGRHVVRDGAHTLVPDVPQALARAVEALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZE7</accession>
    <name>Q9KZE7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631071.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031374.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7006"/>
    <dbReference type="GeneID" id="1102444"/>
    <dbReference type="KEGG" id="sco:SCO7006"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7108"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZE7"/>
    <dbReference type="OMA" id="HPGFGLH"/>
    <dbReference type="PhylomeDB" id="Q9KZE7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="416" mass="43530" checksum="D68CEA2590518C23" modified="2000-10-01" version="1">MTSRQADVLVVGAGPAGLTAAARLARTGARVVLLEREQSPGGVPRHCAHRGFGDRPHALTGPAHARLLADAAARAGADLRTGVTALDWAGPRALTTVGPRGAETLAARAVVLATGARERPRAARLVPGTRPAGVYTTGELQQAVHLYGQHIGTRAVIVGAEGVSHAAADTVRAAGADVLALVTELPQAPAAPAWALAARLRHRTPVLTGTKVTELLGRGRLSGVRVRHRDGRSTVLACDTVVFTGDFVPDHELARRGALTLDPGTRGPAVDGALRTSRPGVFAVGSVLHAVESAATAAREGAHAATAVRRWLQDGTDPGDPYWPGGVPLLAGPPLLRIAPNRVTPDDRLPYLLRTAVPLSHPALYVTQDGRPLHRERFHLGTAVPHRPLKLTARWTHRVDPRGGPVHVTVGRPHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZV9</accession>
    <name>Q9KZV9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4142</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628319.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974827.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4142"/>
    <dbReference type="GeneID" id="1099582"/>
    <dbReference type="KEGG" id="sco:SCO4142"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4206"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZV9"/>
    <dbReference type="OMA" id="NAMDLWV"/>
    <dbReference type="PhylomeDB" id="Q9KZV9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004328664" description="Phosphate-binding protein PstS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="7">
        <location>
            <begin position="50"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="370" mass="38041" checksum="4618B90510B4B909" modified="2000-10-01" version="1">MNRRALALGALAVSGALALTACGSDDTGGNSGSDSSSAAANSNIKCDDAKGQLQASGSSAQKNAIDAWVKQYVAACNGVQINYNPTGSGAGITAFTQGQTAFAGSDSALKPDEIEASKKVCKDGQAIDLPMVGGPIAVGFNVTGVDSLVLDAPTMAKIFDSKITNWNDEAIKKLNPDAKLPDLKIQAFHRSDESGTTDNFTKYLKAAAPDDWKYEGGKSWEAKGGQSAQGSSGLAGQVKQTPGAISYFELSYAKDGIKTVDVKTAAAEPVKATVENATAAIGAAKVVGTGKDLALELDYTPDAAGAYPLVLVTYEIACDKGNKADTLPATKSFLNYMASEDGQGLLADAGYAPMPTEIITKVRETISGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L077</accession>
    <name>Q9L077_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl/propionyl CoA carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2776</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB87213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627006.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028579.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L077"/>
    <dbReference type="STRING" id="100226.SCO2776"/>
    <dbReference type="GeneID" id="1098210"/>
    <dbReference type="KEGG" id="sco:SCO2776"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2833"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_11"/>
    <dbReference type="InParanoid" id="Q9L077"/>
    <dbReference type="OMA" id="AYLPIMS"/>
    <dbReference type="PhylomeDB" id="Q9L077"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:leucine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB87213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="538" mass="57413" checksum="B7B838812BBCC5B2" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L114</accession>
    <name>Q9L114_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625726.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027790.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1445"/>
    <dbReference type="GeneID" id="1096871"/>
    <dbReference type="KEGG" id="sco:SCO1445"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1455"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_5_1_11"/>
    <dbReference type="InParanoid" id="Q9L114"/>
    <dbReference type="OMA" id="TQFHDLV"/>
    <dbReference type="PhylomeDB" id="Q9L114"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="27046" checksum="7485E9042D8D59E4" modified="2000-10-01" version="1">MTTILVTGGTGTLGRLVTERLRTGGHEVRVLSRHSEPYAVDLREGGSGLDAALAGVDTVVHCATTQRGGDERSAANLIAAARRAGATHLVYISIVGVDRVPLGYYRSKYAVEKLVAESGIGWTVLRATQFHDLVVQMLRALAKLPVVVLPAHASDQPVEVAEVADRLAELAQGAPAGRVPDMGGPEVRTFASLARAYLGATGRRRAVVNVPLAGRTYRAFRAGGHLAPEHAVGEGTFEEYLAGRFGHREGGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L136</accession>
    <name>Q9L136_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7423</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631472.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031654.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7423"/>
    <dbReference type="DNASU" id="1102861"/>
    <dbReference type="GeneID" id="1102861"/>
    <dbReference type="KEGG" id="sco:SCO7423"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7533"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074354_2_0_11"/>
    <dbReference type="OMA" id="PCFDAAR"/>
    <dbReference type="PhylomeDB" id="Q9L136"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="236" mass="26119" checksum="C4FCFA9866737BFF" modified="2000-10-01" version="1">MDDWRRFAQQMASLARDLLSQESLHDTLDRITASATELVEDCDAAGILILRGTKVQSLAPTEQVVIDSDALQGRVGEGPCFDAARSGTGERQFRIADFTDEAQRWPKYVPEARKLNLGSMMGFLLFTEDEDLGALNMYSYRPGAFTEADETAGWLLASHAAVAFSSARTHAQMQEAIGTRHIIGEAMGILMGRHRMSEDQAFAALRRYSQDHNVKLRNVAAQVCERGGLPEPTDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1L6</accession>
    <name>Q9L1L6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5428</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629566.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973570.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5428"/>
    <dbReference type="GeneID" id="1100868"/>
    <dbReference type="KEGG" id="sco:SCO5428"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5509"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L1L6"/>
    <dbReference type="OMA" id="MMWGNFF"/>
    <dbReference type="PhylomeDB" id="Q9L1L6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB72404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="32012" checksum="4BB451BFF69ED9AC" modified="2000-10-01" version="1">MTDTVAPRPASRTSRAARRTTPAARRNRRRTAADAGLLVAAAAFVLPLAWVVLSALDPHASLRVKVPDGVTLDNFDAILTPEITFTPLLNSLILCGGATLLTVVCAVLAAYPLSRFRSRLNRPFLLTILFATSLPITAIMVPVYALFVRVNMIDTMQGTIFFFAASQLPFAIWLMKNFMDGVPKELEEAAWTDGASSFQSLLRIVLPLMGPGVAVVTVFSFVMMWGNFFVPFMLLLSPDQMPASVSINDFFGNRGMVAYGQLAAFSIVYSTPVVLLYVLISRRLGGGFALGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Y5</accession>
    <name>Q9L1Y5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626886.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028482.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2650"/>
    <dbReference type="GeneID" id="1098084"/>
    <dbReference type="KEGG" id="sco:SCO2650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2696"/>
    <dbReference type="HOGENOM" id="CLU_160738_1_0_11"/>
    <dbReference type="OMA" id="FSAEGPC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="103" mass="10437" checksum="32E4D410F654CD21" modified="2000-10-01" version="1">MAALAPLLLPAPSKPVAEPSTPWAEPSAASETPHYCVFGATGSCAETPLTSEPPLPDAEPLTSESPFADAVPLTSESSPELTADVPDQGGPSFAVPVPEPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Y8</accession>
    <name>Q9L1Y8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626883.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028479.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2647"/>
    <dbReference type="GeneID" id="1098081"/>
    <dbReference type="KEGG" id="sco:SCO2647"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2693"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_5_11"/>
    <dbReference type="InParanoid" id="Q9L1Y8"/>
    <dbReference type="OMA" id="YEATMVT"/>
    <dbReference type="PhylomeDB" id="Q9L1Y8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="18859" checksum="C42D1EC5D4629A74" modified="2000-10-01" version="1">MTERPPQPGPRKDPVDVIIDQWAAARPDLDTAAMEVFGRVFRLARAMGDRMEKAYERFGISRGEFDALATLRRSGEPYTLSPRQLSATLMLTTGGMTGRLDKLERAGLLRRSPDPHDRRGLQVTLTERGLELIDEAVGAGLDAQTEALSSLDAERSGQLAGLLRDLLAGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2E4</accession>
    <name>Q9L2E4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626717.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976329.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2475"/>
    <dbReference type="GeneID" id="1097909"/>
    <dbReference type="KEGG" id="sco:SCO2475"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2517"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9L2E4"/>
    <dbReference type="OMA" id="AIWPARS"/>
    <dbReference type="PhylomeDB" id="Q9L2E4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="32869" checksum="C2C8EE85F19E94EB" modified="2000-10-01" version="1">MSLRQFEYALAVAEEGSVTAAAEALRVAQPSVSQQIRGLERDLGVELFSRTPTGLVPTVAGRAFLRDAEIAVNAARRARATARAGSEELAGELVVAVQMGLGTRQLPGALSALRRRFPRLEVTVFEEPNPTELERLARGGVIDLALMAGPCDEGLYDGHHLGDEEFVVVLAAGHPQLAVDRVALRDLEREPWVRFDPASALDGVLVDVLRENGLAPTTVARVSQTATAVRWAAHGLGVTFVPASAVPPGHEHLVRPVSPAVSQPVVAAVRPGAGPAETALLEFLRQETWYRFAQSWVAPPSTASSAPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCY0</accession>
    <name>Q9RCY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0930</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625228.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027453.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0930"/>
    <dbReference type="GeneID" id="1096353"/>
    <dbReference type="KEGG" id="sco:SCO0930"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.924"/>
    <dbReference type="eggNOG" id="COG4315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058029_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RCY0"/>
    <dbReference type="OMA" id="CWPIYTF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043448">
        <property type="term" value="P:alkane catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176859" evidence="2">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="32029" checksum="C9DE1652DA0A3FFB" modified="2000-05-01" version="1">MKTSWRSASLVAGAAALLALTTACGQDGGGPTGSQNVGATAAPGDVGDLGTGAGDGVGTGAGAGAGQASANAPEPAGKLSVSANAEIGDLVTDGAGRTLYRFDADTAQPPKTTCENDCATKWPPVAADDALAGEGIDKELLGEVTRPDGTKQLTIGGWPAYRYAKDTAAGDVKGQGVGKKWYALAADGKKAKAEPAAGLSTREDPKLGEIVVDKNGMTVYRFMKDEAWPKPVSACTGACLAKWPVVAPVEANDTEGVVKKGLMSFTRPDGAAQQTIDCWPIYTFAGDKKAGDTNGQGVGGTWYAVKPDGKPVGAPKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDA3</accession>
    <name>Y2848_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0303 protein SCO2848</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2848</name>
        <name type="ORF">SCE20.22</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0303 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028617.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RDA3"/>
    <dbReference type="SMR" id="Q9RDA3"/>
    <dbReference type="STRING" id="100226.SCO2848"/>
    <dbReference type="GeneID" id="1098282"/>
    <dbReference type="KEGG" id="sco:SCO2848"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2907"/>
    <dbReference type="eggNOG" id="COG4702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101036_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RDA3"/>
    <dbReference type="OMA" id="AWIDRKR"/>
    <dbReference type="PhylomeDB" id="Q9RDA3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00761">
        <property type="entry name" value="UPF0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000208922" description="UPF0303 protein SCO2848">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00761"/>
        </source>
    </evidence>
    <sequence length="158" mass="17185" checksum="60F9814F52DFED7A" modified="2000-05-01" version="1">MSTAPTAPTVAELEEQERRLVFRRFTNDDAWALGSLLVELAREREAPVAIDIHRAGQQLFHAALPGSAPDNDAWIARKRRVVERYGSASYLVGSRFRAKGTTFEESSRLDPDAYAAHGGSFPVTVAGVGVVGAVTVSGLPQVEDHRLVVEALERFIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDD8</accession>
    <name>Q9RDD8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626791.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976251.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2553"/>
    <dbReference type="GeneID" id="1097987"/>
    <dbReference type="KEGG" id="sco:SCO2553"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2598"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RDD8"/>
    <dbReference type="OMA" id="MDNARPF"/>
    <dbReference type="PhylomeDB" id="Q9RDD8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="37328" checksum="03C53CB12C57340D" modified="2000-05-01" version="1">MSSALTDLFPYPIVQAPMAGGVSVPRLAAAVSEAGGLGFLAAGYKTADGMYQEIKQLRGLTSRPFGVNLFLPQPETADPAAVDVYAHQLAGEAAWYETELGDPDCGRDDGYDTKVAVLLDNPVPVVSFHFGVPSREVVDSLHRVGTFALVGATTADEARAVEQSGADAVIAQGMEAGGHQGTHRDNPETGGAGTGLLSLVAQVREAVSLPILAAGGIMRGGQIAAVLAAGASAAQLGTAFLATSESGAHDLHKQALTNPLFVRTELTRAFSGRPARALVNRFLREHGPYAPAAYPEVHHLTAPVRKAAAKAGDAQGMALWAGQGHRMARELPAGQLVEVLVAELAAAGTALSGLSGYATGGGAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDE4</accession>
    <name>RNZ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Z</fullName>
            <shortName evidence="1">RNase Z</shortName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnz</name>
        <name type="ordered locus">SCO2547</name>
        <name type="ORF">SCC77.14c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="1"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626785.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028422.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RDE4"/>
    <dbReference type="SMR" id="Q9RDE4"/>
    <dbReference type="STRING" id="100226.SCO2547"/>
    <dbReference type="GeneID" id="1097981"/>
    <dbReference type="KEGG" id="sco:SCO2547"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2592"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RDE4"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="PhylomeDB" id="Q9RDE4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042779">
        <property type="term" value="P:tRNA 3'-trailer cleavage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000155904" description="Ribonuclease Z">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <sequence length="301" mass="33377" checksum="9F235A4018409419" modified="2000-05-01" version="1">MSVRELVVLGTASQVPTRHRNHNGYLLRWDGEGILFDPGEGTQRQMLRAGVAAHDLNRICVTHFHGDHSLGLAGVIQRINLDRVPHEITAHYPRSGQRFFERLRYATAYRETVALTEVPVAADGPLAVTPAYTLDARRLSHPVESYGYRLTEPDGRRMLPERLAAHGITGPDVGRIQRDGSLGGVALDEVSEVRRGQRFAFVMDTRLCEGVHALAEDSDLLVIESTFLDEDETLATDHGHLTAGQAARVARDAGVRHLVLTHFSQRYSDPEEFGRQARAAGYAGELTVARDLTRVPVPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDQ3</accession>
    <name>Q9RDQ3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2381</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028316.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2381"/>
    <dbReference type="GeneID" id="1097815"/>
    <dbReference type="KEGG" id="sco:SCO2381"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2422"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_2_11"/>
    <dbReference type="OMA" id="HMTANPQ"/>
    <dbReference type="PhylomeDB" id="Q9RDQ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="31105" checksum="EAA1C6FA1E26CBDD" modified="2000-05-01" version="1">MANIQSLDPTASPLDYYGWELRRQREAHGLRQGQLGDIIFCTGSLVGQIETTKKVPTRDFSERVDAALGTDGLFSRLIGLVLRSQLPTWFQPYAEMEAKAAYISTYQAQLVYGLLQTEEYARAVLGVEGGNVDEMVAARLERQRILQRDQPPALWVILDEAALLREIGGPEVMRDQLAHLLGFAAAPWVQIQVLPLAVGQHAAMMGTFNLLRFDTDPDLFYMDGYDRGHMTASPDVIKERSFGYARLQASALSPEDSARLITRVMEERYAVPHSTEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS4</accession>
    <name>Q9RDS4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2243</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626492.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028219.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2243"/>
    <dbReference type="GeneID" id="1097676"/>
    <dbReference type="KEGG" id="sco:SCO2243"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2281"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_11"/>
    <dbReference type="InParanoid" id="Q9RDS4"/>
    <dbReference type="OMA" id="TEVFWAA"/>
    <dbReference type="PhylomeDB" id="Q9RDS4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB66177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="21256" checksum="BD24401A2678F8C9" modified="2000-05-01" version="1">MSVQERKQREWAERERLIVATARELAEQQGWDAVTTRRLAERIEYSQPVLYSHFRGKREIIGAVALQGATEMAVAMRAATAAADGPRARVHALARAYLAFAERNPAVYDAIFQLDGGLAYAREDTPEPLKDAFAALLESLGEVAGDGVEPGLFTEVFWASLHGVTTLTRSGRLPPEETERRVQLLVDRLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI71</accession>
    <name>Q9RI71_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative insertion element transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0106</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37006">
        <property type="entry name" value="T37006"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624449.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026850.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0106"/>
    <dbReference type="GeneID" id="1095531"/>
    <dbReference type="KEGG" id="sco:SCO0106"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.88"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RI71"/>
    <dbReference type="OMA" id="WTWHRRM"/>
    <dbReference type="PhylomeDB" id="Q9RI71"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="14669" checksum="D250387A2490B5FE" modified="2000-05-01" version="1">MSLTDAQWARIEPLLPDRTPRRAGQWRDHRQVIDAIVFKYRTGTPWMELPERFGSWKGAHNRLRMWAVDGTWEKVFTALLAQADAEGDLDWVIPVDSAVVRAHQHAAGARQKGLRPASRTTMPSDGPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIV0</accession>
    <name>Q9RIV0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hpothetical protein SCM11.11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0956</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625253.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027468.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0956"/>
    <dbReference type="GeneID" id="1096379"/>
    <dbReference type="KEGG" id="sco:SCO0956"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.953"/>
    <dbReference type="eggNOG" id="COG4341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091985_1_0_11"/>
    <dbReference type="OMA" id="HEHALQT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="16207" checksum="0074B8850B2D22EA" modified="2000-05-01" version="1">MELRSVEELMDLLYACRGERPANGATGGPVGGPGDPHGHALRTAALLRRRRPADKELQVAGLVSPVGRLLWPGSPAARTAAAVGPLLGARVARLVRRQAHPEAWDHDDDLVSLRQAEEEARTAVFDAGVLEDWRTVLELTAARNSRLGAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIX9</accession>
    <name>Q9RIX9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phytoene dehydrogenase (Phytoene desaturase) (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0186</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36968">
        <property type="entry name" value="T36968"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624522.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026910.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0186"/>
    <dbReference type="GeneID" id="1095610"/>
    <dbReference type="KEGG" id="sco:SCO0186"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.159"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RIX9"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="PhylomeDB" id="Q9RIX9"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB53153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="523" mass="55650" checksum="955AFDC7625EEB6D" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY3</accession>
    <name>Q9RIY3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0182</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36964">
        <property type="entry name" value="T36964"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624518.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026906.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0182"/>
    <dbReference type="GeneID" id="1095606"/>
    <dbReference type="KEGG" id="sco:SCO0182"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.155"/>
    <dbReference type="HOGENOM" id="CLU_2686127_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="74" mass="7804" checksum="9B2F9462B3198AB7" modified="2000-05-01" version="1">MCRAAVGVLEAGARREGVTCGTYGLWDGVTAWREPRSSMPDLTQVLKPIEGSDLVPAASVVAAHAEDRLKGEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ19</accession>
    <name>Q9RJ19_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1849</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626117.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028008.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1849"/>
    <dbReference type="GeneID" id="1097283"/>
    <dbReference type="KEGG" id="sco:SCO1849"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1873"/>
    <dbReference type="eggNOG" id="COG1429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002017_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ19"/>
    <dbReference type="OMA" id="YQFQGGL"/>
    <dbReference type="PhylomeDB" id="Q9RJ19"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1217" mass="130905" checksum="F188922BDF655C1F" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ73</accession>
    <name>Q9RJ73_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1628</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625903.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977198.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1628"/>
    <dbReference type="GeneID" id="1097059"/>
    <dbReference type="KEGG" id="sco:SCO1628"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1643"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_3_1_11"/>
    <dbReference type="OMA" id="GNPERLY"/>
    <dbReference type="PhylomeDB" id="Q9RJ73"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="138" mass="14610" checksum="002BD058D76F5E0F" modified="2000-05-01" version="1">MTPPRRQRRSPGPDRPAAPAPPGAPAKEGEVRNPERLFVIGGEGGGERADIDLVTLIVARADPPVSATPEQAALLRLCAAPLSVAELSAYLSLPFSVVTVLLTDLLASELVQARAPIVRQKVADRNLLEAVMHGLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ93</accession>
    <name>Q9RJ93_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0672</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624981.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978190.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0672"/>
    <dbReference type="GeneID" id="1096095"/>
    <dbReference type="KEGG" id="sco:SCO0672"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.656"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474339_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ93"/>
    <dbReference type="OMA" id="TQPFGRV"/>
    <dbReference type="PhylomeDB" id="Q9RJ93"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="76"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="18953" checksum="56D19154DF0033C5" modified="2000-05-01" version="1">MCHHTSDRSQRNAVARAEPGGAGSGRCVPVRTSGPTRAAKGLNIEPPDDGRAHAAHARSEGSVAEIEGAAVPERLLITRTTTGDGVCLVILAGEVDLDGSGHLRDVLLSSVESAPGTVVDFGEVGFLDSSGINVLISAHRAAESRGVFFRLAAPRDAVERVLRLVGVDALIPCYPSVEQALTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB4</accession>
    <name>GVPA2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable gas vesicle structural protein 2</fullName>
            <shortName>GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gvpA2</name>
        <name type="ordered locus">SCO0650</name>
        <name type="ORF">SCF91.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
            <location evidence="1">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624959.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027272.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJB4"/>
    <dbReference type="STRING" id="100226.SCO0650"/>
    <dbReference type="GeneID" id="1096073"/>
    <dbReference type="KEGG" id="sco:SCO0650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.634"/>
    <dbReference type="eggNOG" id="ENOG50328MZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117660_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJB4"/>
    <dbReference type="OMA" id="VPEMFGS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0304">Gas vesicle</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000199991" description="Probable gas vesicle structural protein 2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="170" mass="19422" checksum="57C97217BE59ACDC" modified="2000-05-01" version="1">MITYDDEVVCAPRAGTLYDVLELILDRGMVIDVFVRVSLVGIEILKVDARIVVASVDTYLRFAEACNRLDLEHDVRSKTVPEMFGSPMAKTVGRAGARRTARSLTDKVRDVLTPEHEHEEEPEEAEDRPRAGAERGRSTQRPRSRPAARPRDEDDRPRSRPRRRTEEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJJ2</accession>
    <name>Q9RJJ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0396</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624718.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0396"/>
    <dbReference type="GeneID" id="1095819"/>
    <dbReference type="KEGG" id="sco:SCO0396"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.372"/>
    <dbReference type="eggNOG" id="COG4310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052015_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJJ2"/>
    <dbReference type="OMA" id="TVPQEWN"/>
    <dbReference type="PhylomeDB" id="Q9RJJ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032610">
        <property type="entry name" value="DUF2172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032589">
        <property type="entry name" value="DUF4910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012353">
        <property type="entry name" value="UCP015244"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032622">
        <property type="entry name" value="UCP01524_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09940">
        <property type="entry name" value="DUF2172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16254">
        <property type="entry name" value="DUF4910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16221">
        <property type="entry name" value="HTH_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015244">
        <property type="entry name" value="UCP015244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF4910" evidence="4">
        <location>
            <begin position="9"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2172" evidence="2">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_47" evidence="3">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015244-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB58337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="424" mass="46997" checksum="834C16167E206880" modified="2000-05-01" version="1">MTQAGGEMYALVERLYPLCRSITGDGVRATLDIVDEYIPLHMHEVPTGTQVLDWTVPQEWNIRDAYVADATGRRVVDFAASSLHVLGYSVPVSATMPLAELRPHLHTLPDHPAWVPYRTSYYRPQWGFCLAQETLDALPEGDYEVRIDSTLADGHLTYAEHVVQGQVSDEVIVSCHVCHPSLANDNLAGIAVATFLARELAERNPYYTYRFVFAPGTIGAITWLARNRERVERVKHGLVLACAGDPGQVTYKQSRRGDAEIDRVLRHVLTDSERPHRVVEFTPYGYDERQYCSPGFDLGVGSLTRTPYAGYPEYHTSADNLDFVSPAAMADTLAVCREAFSVLDRNRRYVNLSPYGEPQLGRRGLYDSLGGRSDAKQAQMAMLWVLSLSDGEHSLLDVAEQSGLPFETVVEAADALHGAGLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK95</accession>
    <name>Q9RK95_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0267</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624597.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026973.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0267"/>
    <dbReference type="ESTHER" id="strco-SCF1.09">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1095691"/>
    <dbReference type="KEGG" id="sco:SCO0267"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.240"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_11"/>
    <dbReference type="InParanoid" id="Q9RK95"/>
    <dbReference type="OMA" id="HYWGGSA"/>
    <dbReference type="PhylomeDB" id="Q9RK95"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27454" checksum="4E9B7CFECA5802C5" modified="2000-05-01" version="1">MSTTQHTLVPVYDHRTGTGPTLVFLHYWGGSARTWDLVVDRLPGRAVVAVDFRGWGRSRALPGPYTLGRFADDTLAVLADAGITDYVLVGHSMGGKVAQLVAATRPAGLRAIVLVGSGPAKPAARVTPEYREALSHAYDSAESVAGARDHVLTATELPAALKARIVTDSRNVTDAARIEWPLRGIAQDITEHTRRIDVPALVVAGEHDQVEPAGVLRDNLVPYLARADFVVVPRTGHLIPLEAPADLADAVTAFATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKG4</accession>
    <name>Q9RKG4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3473</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029012.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKG4"/>
    <dbReference type="STRING" id="100226.SCO3473"/>
    <dbReference type="DNASU" id="1098910"/>
    <dbReference type="GeneID" id="1098910"/>
    <dbReference type="KEGG" id="sco:SCO3473"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3532"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RKG4"/>
    <dbReference type="OMA" id="MPGAMTI"/>
    <dbReference type="PhylomeDB" id="Q9RKG4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="22548" checksum="3595524E04F417AD" modified="2000-05-01" version="1">MPRYETASRIARDGVVAVVRSHSPDLAREQALALLKAGQRVVEVSMTTPGALDVVADLSHGWPAHEALIGVGTVLDEATVRMSELAGARFVVSPTVNRTVLRAAHRYGMATLAGALSPTEAATAIEEGADFVKLFPASVYGADAVRHLLAPFPQLALVPTGGVPLELAPDYIRAGAVAVGIGSELTSGDPRSIEGRVRQLRTAVAREKAERTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKG8</accession>
    <name>Q9RKG8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3464</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627668.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029005.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3464"/>
    <dbReference type="GeneID" id="1098901"/>
    <dbReference type="KEGG" id="sco:SCO3464"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3524"/>
    <dbReference type="eggNOG" id="COG3222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075662_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RKG8"/>
    <dbReference type="OMA" id="IGTDCPG"/>
    <dbReference type="PhylomeDB" id="Q9RKG8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="21914" checksum="213C80933BE6CC4D" modified="2000-05-01" version="1">MAKAPRPGTVKTRLHPLLGPQRCAKLQAELIRHTMAVTTAHTPSAYLAYAPNDGKDAISTAVPAGVRLLRQCGEDLGQRLAAAVTDAFTDGAGPLLVIGTDAPTLTADHLSAAFTALEHHDVTLGPALDGGYYLIGLRAPHTSLFALAPDVWSTDRVLAATRALADGEGLSTGMLRPLRDLDTPEDAAALLTDPALPTPIAALLQPKEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S201</accession>
    <name>Q9S201_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0125</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37055">
        <property type="entry name" value="T37055"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026866.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0125"/>
    <dbReference type="GeneID" id="1095549"/>
    <dbReference type="KEGG" id="sco:SCO0125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.102"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040029_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S201"/>
    <dbReference type="OMA" id="NNPKRKM"/>
    <dbReference type="PhylomeDB" id="Q9S201"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04742">
        <property type="entry name" value="NPD_FabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014179">
        <property type="entry name" value="PfaD_fam"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02814">
        <property type="entry name" value="pfaD_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="527" mass="56491" checksum="80C747F721C378EA" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S241</accession>
    <name>Q9S241_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1711</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36812">
        <property type="entry name" value="T36812"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625985.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027934.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1711"/>
    <dbReference type="GeneID" id="1097142"/>
    <dbReference type="KEGG" id="sco:SCO1711"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1729"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_11"/>
    <dbReference type="InParanoid" id="Q9S241"/>
    <dbReference type="OMA" id="DQMPKHV"/>
    <dbReference type="PhylomeDB" id="Q9S241"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB46809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="747" mass="78322" checksum="6D2C3A09B5F0E180" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Y6</accession>
    <name>Q9S2Y6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2029</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34872">
        <property type="entry name" value="T34872"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626289.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028106.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2029"/>
    <dbReference type="GeneID" id="1097463"/>
    <dbReference type="KEGG" id="sco:SCO2029"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2060"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S2Y6"/>
    <dbReference type="OMA" id="FDARYTQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="425" mass="43366" checksum="D597FF8CB6666BA2" modified="2000-05-01" version="1">MSRPRGAVGATGTTAYVAGPGVPEVSGPGGSGHRPGSEPDTAAASRGVPLSDRVEGLLLGLAAGDAAGWPAARHRAARMPQWTRRLTRELDTFAEQNATTTLPVPIALNQPPEPLRLGPSDDAEWAAFAAEALLRAGDDSVLGDLSRDRRMRAAIDLTWNAVASEVAAATERAPEAESAVLPLRARISVRAGLGNLAAGLRPPATGHDNPHYFDDAACVRACVLAVAHPGAPRLAADLAEFDARYTQDGDGVHGARAMAAALARALDGTDVDACVAAALAELPEATEIGRNARQALALAAAAESTFALVPLLEHRIVDHVYSYGIAAAETVPVALALTVAARGRLAETVPAAACLSRVADSAPALAGALTGALGGGASVPASWRDACRTLPGCVLPRLTGTDLVELAGLLHATRPSPPEGRDTTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="147" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX15</accession>
    <name>HEM1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="1">GluTR</shortName>
            <ecNumber evidence="1">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemA</name>
        <name type="ordered locus">SCO3319</name>
        <name type="ORF">SCE68.17c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="1"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36267">
        <property type="entry name" value="T36267"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627529.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028907.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9WX15"/>
    <dbReference type="SMR" id="Q9WX15"/>
    <dbReference type="STRING" id="100226.SCO3319"/>
    <dbReference type="GeneID" id="1098753"/>
    <dbReference type="KEGG" id="sco:SCO3319"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3379"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_4_0_11"/>
    <dbReference type="InParanoid" id="Q9WX15"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="PhylomeDB" id="Q9WX15"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019353">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process from glutamate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Insert">
        <location>
            <begin position="292"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <sequence length="581" mass="60562" checksum="D4E256B105AFA037" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X819</accession>
    <name>Q9X819_STRCO</name>
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        <recommendedName>
            <fullName evidence="1">Fe-S_biosyn domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2161</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB39888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_003976654.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2161"/>
    <dbReference type="GeneID" id="1097595"/>
    <dbReference type="KEGG" id="sco:SCO2161"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2198"/>
    <dbReference type="eggNOG" id="COG0316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_0_11"/>
    <dbReference type="InParanoid" id="Q9X819"/>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="PhylomeDB" id="Q9X819"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005506">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0106035">
        <property type="term" value="P:protein maturation by [4Fe-4S] cluster transfer"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
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            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB39888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="118" mass="12390" checksum="E0E4BC1E49CD2DE7" modified="1999-11-01" version="1">MSVSDETTTVTDGIILTDAAAAKVKALLDQEGRDDLALRVAVQPGGCSGLRYQLFFDERSLDGDVVKDFGGVKVTTDRMSAPYLGGATVDFVDTIEKQGFTIDNPNATGSCACGDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X850</accession>
    <name>Q9X850_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3389</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
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                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB40929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T36077"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975444.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3389"/>
    <dbReference type="GeneID" id="1098826"/>
    <dbReference type="KEGG" id="sco:SCO3389"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3452"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9X850"/>
    <dbReference type="OMA" id="LDRFAPM"/>
    <dbReference type="PhylomeDB" id="Q9X850"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB40929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24159" checksum="C02DAC8A6FC82E2E" modified="1999-11-01" version="1">MAIRVMLVDDQVLLRTGFRMVLAAQPDMEVVAEAGDGVEALQVLRSTAVDVVLMDVRMPKLDGVETTSRICVDPNAPKVLILTTFDLDEYAFSALKAGASGFMLKDVPPGELLAAIRSVHSGDAVVAPSTTRRLLDRFAPMLPATGQEPRQKELQRLTEREREVMVLVAQGMSNGEIAARLVLSEATVKTHVGRILTKLGLRDRVQVVVLAYETGLVRAGGGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8F1</accession>
    <name>Q9X8F1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3278</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36238">
        <property type="entry name" value="T36238"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627490.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028882.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3278"/>
    <dbReference type="GeneID" id="1098712"/>
    <dbReference type="KEGG" id="sco:SCO3278"/>
    <dbReference type="HOGENOM" id="CLU_3258235_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="42" mass="4168" checksum="999E9AABE3EA1500" modified="1999-11-01" version="1">MAGAGAVGVPSRHAVREGASMAPKAGRRRARQSVAGRHGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X902</accession>
    <name>Q9X902_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3720</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36655">
        <property type="entry name" value="T36655"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_221481_1_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="27" mass="2796" checksum="5DF8A5561EA2F154" modified="1999-11-01" version="1">MADVAFVLTTIAVFAFVALVAKGVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X903</accession>
    <name>Q9X903_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3721</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36656">
        <property type="entry name" value="T36656"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627913.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975219.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X903"/>
    <dbReference type="STRING" id="100226.SCO3721"/>
    <dbReference type="GeneID" id="1099157"/>
    <dbReference type="KEGG" id="sco:SCO3721"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3781"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_4_1_11"/>
    <dbReference type="InParanoid" id="Q9X903"/>
    <dbReference type="OMA" id="GHEGCGA"/>
    <dbReference type="PhylomeDB" id="Q9X903"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB44424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="207" mass="21442" checksum="4A9CBA8926018568" modified="1999-11-01" version="1">MPDLSPSSPAEAYAALLQGNARFVSGDRLHPNQDADRRSELAPRQHPFAVLFGCSDSRLAAEIIFDRGLGDLFVVRTAGHVAGAEVLGSVEYGVNVLGAPLVVVLGHDSCGAVTAAAEAERGGAAPAGYLGDVVERVIPSVLAARALGRTEIDQFVDEHIRRSVDGLVSRSALLANEVAAGRCAVVGLSYRLAGGTVKRVAAHGLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA75</accession>
    <name>Q9XA75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3802</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36483">
        <property type="entry name" value="T36483"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627991.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975139.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3802"/>
    <dbReference type="GeneID" id="1099238"/>
    <dbReference type="KEGG" id="sco:SCO3802"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3870"/>
    <dbReference type="eggNOG" id="ENOG502ZDJ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173182_1_0_11"/>
    <dbReference type="OMA" id="FATDWHM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB46925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="83" mass="8937" checksum="1867DDDE923DC107" modified="1999-11-01" version="1">MGLGGCIILIAVGAILTFATDWDMQGVNLDLVGVIFMVVGLIGVATFSSIARRRRVVMPPTTPVVEERPHHHTQDGYRDGYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAA0</accession>
    <name>Q9XAA0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36438">
        <property type="entry name" value="T36438"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625125.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027375.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0825"/>
    <dbReference type="GeneID" id="1096248"/>
    <dbReference type="KEGG" id="sco:SCO0825"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.817"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066229_0_0_11"/>
    <dbReference type="OMA" id="WRQHRWT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB48902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="34625" checksum="5FF198367F230E2E" modified="1999-11-01" version="1">MKGTLWLAWRQQRALIVCGAAVLLAAAALAAYSRAGMVDDLRSGLFDGCDPGPLYCTRAPDGLPRFLDVEPLRLLGALNIALPALVGMFWGAPLLGRDRELGTHRMVLTQGVGRAQWFASRFALAALGTVMLSGALALLFRWWWEPAANRSYGLFWYEATALTGSGPSLVAAALFGLAVGTLAGLLTRRVLAAMAWTLLVTGVVAVAVQWTHRARLLVPPHRYVSDGWQPKEPMGDKWSTGHYGLITGSGRRDSALECASPSGRELRECMTRHGYVSRYYEANPAGDYWSFQWTDTALLGGLALVLVLVTVLLLRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAG1</accession>
    <name>Q9XAG1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35617">
        <property type="entry name" value="T35617"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629454.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973660.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9XAG1"/>
    <dbReference type="STRING" id="100226.SCO5312"/>
    <dbReference type="GeneID" id="1100752"/>
    <dbReference type="KEGG" id="sco:SCO5312"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5398"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_0_1_11"/>
    <dbReference type="InParanoid" id="Q9XAG1"/>
    <dbReference type="OMA" id="EYRSVMV"/>
    <dbReference type="PhylomeDB" id="Q9XAG1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="15587" checksum="5C189A202566B083" modified="1999-11-01" version="1">MTTTPRFDPRVLLAESRLGVLATIKSDGRPQLSPVMPAYDPEAGVIRVSTREGLAKTANLRRDPRAALEVTAPDGRSWATAEGVATLTGPGADPHGPEVEALVEYYRAAAGEHPDWDEYRSTMVSDRRVLLTITVERVYGADIG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAJ8</accession>
    <name>Q9XAJ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3604</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35372">
        <property type="entry name" value="T35372"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627799.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975335.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3604"/>
    <dbReference type="GeneID" id="1099040"/>
    <dbReference type="KEGG" id="sco:SCO3604"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3662"/>
    <dbReference type="eggNOG" id="ENOG5031WTD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171133_0_0_11"/>
    <dbReference type="OMA" id="MAHYDER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="96" mass="10731" checksum="F81D03AB71B0B345" modified="1999-11-01" version="1">MPVPEDRRLDEIESRLHREDPQFARAFADGRPRRPREYRYHRAWLLLAAALGALAAGMFLAHGLLIAAGLVFAGVAGELFDPHRRERGTRCPPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XD97</accession>
    <accession>Q7AKJ4</accession>
    <name>Q9XD97_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4542</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="5470" last="5478">
            <title>WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Ainsa J.A."/>
                <person name="Ryding N.J."/>
                <person name="Hartley N."/>
                <person name="Findlay K.C."/>
                <person name="Bruton C.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="10986251"/>
            <dbReference type="DOI" id="10.1128/JB.182.19.5470-5478.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF106004">
        <property type="protein sequence ID" value="AAD42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628705.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029720.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4542"/>
    <dbReference type="GeneID" id="1099982"/>
    <dbReference type="KEGG" id="sco:SCO4542"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4614"/>
    <dbReference type="eggNOG" id="ENOG502ZSJP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_3_0_11"/>
    <dbReference type="OMA" id="PRIAIRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAD42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="6760" checksum="EC869DF959369F7C" modified="1999-11-01" version="1">MTVRPRWRKSSYSEGGDGNTCVEIAALHTRIAVRDSKAPSQGTVTVPIGSFAALIQSLKRSTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z507</accession>
    <name>UVRA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein A</fullName>
            <shortName evidence="1">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrA</name>
        <name type="ordered locus">SCO1958</name>
        <name type="ORF">SCC54.18c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36031">
        <property type="entry name" value="T36031"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028066.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z507"/>
    <dbReference type="SMR" id="Q9Z507"/>
    <dbReference type="STRING" id="100226.SCO1958"/>
    <dbReference type="PRIDE" id="Q9Z507"/>
    <dbReference type="GeneID" id="1097392"/>
    <dbReference type="KEGG" id="sco:SCO1958"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1984"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_11"/>
    <dbReference type="InParanoid" id="Q9Z507"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="PhylomeDB" id="Q9Z507"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000093098" description="UvrABC system protein A">
        <location>
            <begin position="1"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="314"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="612"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="645"/>
            <end position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110998" checksum="084D6B18692A792D" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z510</accession>
    <name>Q9Z510_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative iron sulphur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1955</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36028">
        <property type="entry name" value="T36028"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626219.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976864.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1955"/>
    <dbReference type="GeneID" id="1097389"/>
    <dbReference type="KEGG" id="sco:SCO1955"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1981"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="InParanoid" id="Q9Z510"/>
    <dbReference type="OMA" id="FSAQCTH"/>
    <dbReference type="PhylomeDB" id="Q9Z510"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177067" evidence="4">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB38145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="14076" checksum="DA247522F8987488" modified="1999-05-01" version="1">MPGRPAPSRRTVLRSAAATPVAGLGLAACSPGDDGAAPARPTAPVDLGADGDVAKGATKLFPDGNVVVSRAADGSLKAFSTVCTHAGCPIRKLEGTKLVCNCHGSEFDARTGEVLHAPATVPLVELPVSVEQGRIVASPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z545</accession>
    <name>Q9Z545_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6127</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35910">
        <property type="entry name" value="T35910"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630233.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030671.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6127"/>
    <dbReference type="ESTHER" id="strco-cxest">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="GeneID" id="1101568"/>
    <dbReference type="KEGG" id="sco:SCO6127"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6231"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_0_11"/>
    <dbReference type="InParanoid" id="Q9Z545"/>
    <dbReference type="OMA" id="VYEFAWP"/>
    <dbReference type="PhylomeDB" id="Q9Z545"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="502" mass="53490" checksum="7DCE579D8B1B8C6E" modified="1999-05-01" version="1">MRSGQTNPVVRTVHGAVGGRYEHDVAVFRGIPYAAPPFGPGRFRPPLPPEPWDGVRDAGSFGPTAPKPPYSEAFARYLSDPAIPGDDCLNLNVWTPEPGPGARLPVLVWLHGGALTRGSSAVPVYDGSTFARDGVVCVSVNYRLGVEGYGLFPDAPANAGLRDQIAALQWVRDNIAAFGGDPDRVTVAGQSAGAISTGALLAAPRARGLFRRAVLQSGAPEAADRDKVRRMVRRMASRLKIPATAEAFAAADRDQLLRAQAEVGRFSSPVLGGPGFGLVVDGDVLPRDPLEALVDGDAAPGVDLMMGWTRDEYRLWLVPGGLVERVDRLGAVALAGARARCHCGNEVVRGYRAARPGAGTAEIVGQLVTDHLLRIPMHRVADARPGSSHVYEFAWPSNLPDLGACHALELGFVFDSGDGPDARRLAGEGAPQELADAMHGAWVRFAETGDPGWQAWDAAHPVRVFGDGAPHTAYGPLDPEYDLWKADVTVPRGTRPRRLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z547</accession>
    <name>Q9Z547_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6125</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35908">
        <property type="entry name" value="T35908"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030670.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6125"/>
    <dbReference type="GeneID" id="1101566"/>
    <dbReference type="KEGG" id="sco:SCO6125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6229"/>
    <dbReference type="eggNOG" id="ENOG50333DI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260830_0_0_11"/>
    <dbReference type="OMA" id="DAWYRTS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177069" evidence="2">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="22701" checksum="E2716DC78F2CE730" modified="1999-05-01" version="1">MIRHVRVLPVLVLAPLLLTACGSEKAGDPGPSASASAPASAAGPAAAPGTGELASRAQAMGVAPELVYVTEAPGFTLAQQSVGVLGDEGFSATWVDGGTNALLRLAVDRGTITVGTCPEQPVGDMPGEHTTCERDGKAWYRTGAGRHEYALPEEGHVVRVSAEQDAVPRDVLRAAALAAHRPDAAETDRLLPSAEPAPATPVERGDLPPFGDGAPDNHVDVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O54102</accession>
    <name>O54102_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34578">
        <property type="entry name" value="T34578"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630024.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030525.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5906"/>
    <dbReference type="GeneID" id="1101348"/>
    <dbReference type="KEGG" id="sco:SCO5906"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6004"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083240_1_0_11"/>
    <dbReference type="OMA" id="ACIRRID"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21440" checksum="8654852729BA2F73" modified="1998-06-01" version="1">MPKIEAGSVREHRAQRLAQLIDAAEELLEEGGAEALTAGAVAARAGIARNSIYRYFNSIDDLLELVVTREFPAWIDAVEQAIAAETTPAAQAAAYVRANLEQAARGTHGWRAALTRDSLSPSARERVRNLHISLHEALARVVRELGQPQPELTVAVVQAVVDACIRRIDQGDDLTTVSDFAAGATRRLLADDDLPHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>O69901</accession>
    <name>O69901_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5613</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T34798"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011030339.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO5613"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5704"/>
    <dbReference type="eggNOG" id="ENOG50320Q0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474340_0_0_11"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="21013" checksum="FB221994456E2C0F" modified="1998-08-01" version="1">MNDLDRRGGRIFGRVDGEVDWPSGVDSPYRLMKLRDPEKYEREVARQVDAQRVIVEWAEWYGLKRAKMACCPRWLTHKVSRRCNSRCTAFGGGATDHRWLEHGVGWVLDGQPVALTSASYGISDEYRARFEWWVNEDPRLAVALGGQGWYGYGSTQVLVWRTDVIEVMEPAPESVRALGYPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O69922</accession>
    <name>O69922_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6390</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_045535_1_1_11"/>
    <dbReference type="InParanoid" id="O69922"/>
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    <dbReference type="PhylomeDB" id="O69922"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81606"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="367" mass="39382" checksum="667A671A305B158A" modified="1998-08-01" version="1">MDRFQAGDLPDRTARMAVGAAVALVLVIILADVISPKGVYLSPMLVVAPALTTAFAGPRLTAGVALVAIAAQMVAASLTGSALSAARLWQLSALVVVSILLIFFSYVRQRRARQLSRARRVAEAAQRVLLRPPPERVGPLRIGWQYLTAEDDTQFGGDLFAVTRRRPDSSRVIIGDVRGHGLPAISEASAALGSFREAARRCARLDELALILEESIGWDLEEGGEGPGQEDEHFVTALLLDLPDAHDHASMISCGHSPPLLVHSDGRVTTAHCDPAPPLGLGYLSLTGVRIQTVEYAVGDTLLLYTDGVIEARSPQGEFYPLAKRVRSFPYSESPEVLLKRLRQDLLAHTGGHLSDDAALLAVTRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O69986</accession>
    <name>O69986_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5810</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35130">
        <property type="entry name" value="T35130"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629934.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030470.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5810"/>
    <dbReference type="GeneID" id="1101252"/>
    <dbReference type="KEGG" id="sco:SCO5810"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5902"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="O69986"/>
    <dbReference type="OMA" id="AACQLMV"/>
    <dbReference type="PhylomeDB" id="O69986"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA18346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="515" mass="53714" checksum="8EA837C942C68AFC" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O86585</accession>
    <name>O86585_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6220</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37218">
        <property type="entry name" value="T37218"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630321.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030747.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6220"/>
    <dbReference type="GeneID" id="1101661"/>
    <dbReference type="KEGG" id="sco:SCO6220"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6334"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000662_1_0_11"/>
    <dbReference type="InParanoid" id="O86585"/>
    <dbReference type="OMA" id="GRCMSAA"/>
    <dbReference type="PhylomeDB" id="O86585"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174870" evidence="2">
        <location>
            <begin position="47"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="2183" mass="233390" checksum="373B8EA2BC9998FD" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>O86621</accession>
    <name>O86621_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6352</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29441">
        <property type="entry name" value="T29441"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630444.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030849.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6352"/>
    <dbReference type="GeneID" id="1101793"/>
    <dbReference type="KEGG" id="sco:SCO6352"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6464"/>
    <dbReference type="eggNOG" id="ENOG5033RJG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1854030_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="138" mass="14998" checksum="80C7EF0CD7453FD4" modified="1998-11-01" version="1">MVAHMAAMLPGVRVNVDPEPGPDRGAFQIGSERYRLEAGVTEYVLLARLTAGDRREARPAFLFCGQRAITNQAATRYLARHHEKLARKHGSNSFVLLLKVVNSQAYGPDVVELVGDVTRAATSPLPTPAPASRNSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O86717</accession>
    <name>O86717_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO6535</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35227">
        <property type="entry name" value="T35227"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630616.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972444.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6535"/>
    <dbReference type="GeneID" id="1101974"/>
    <dbReference type="KEGG" id="sco:SCO6535"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6638"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_11"/>
    <dbReference type="InParanoid" id="O86717"/>
    <dbReference type="OMA" id="PFIHPFN"/>
    <dbReference type="PhylomeDB" id="O86717"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAA20632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1231" mass="135896" checksum="F9695F3FDB08E704" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O87592</accession>
    <accession>Q7AKQ1</accession>
    <name>O87592_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5448" last="5453">
            <title>The 20S proteasome of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Nagy I."/>
                <person name="Tamura T."/>
                <person name="Vanderleyden J."/>
                <person name="Baumeister W."/>
                <person name="De Mot R."/>
            </authorList>
            <dbReference type="PubMed" id="9765579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="1999-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="De Mot R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF086832">
        <property type="protein sequence ID" value="AAC64274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625925.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977175.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1650"/>
    <dbReference type="GeneID" id="1097081"/>
    <dbReference type="KEGG" id="sco:SCO1650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1665"/>
    <dbReference type="eggNOG" id="ENOG5033JN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420698_0_0_11"/>
    <dbReference type="OMA" id="VPSCCPD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010839914" evidence="2">
        <location>
            <begin position="44"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC64274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="20239" checksum="35E647F0EE6256C4" modified="1998-11-01" version="1">MQHPAVPDLSHTHTRPIHWVATATAVAGVVALSSVLQPDAATAAQSADKAAAPGPKSAPAHIAPPDPATVAFPLECGPVKALVQKKASGDLDGDGRPETVAAVHCDAPMGTPPDGVYVITRDTDGGKPRVVATLVDPKDRRTATELSVRDGVVRATLLGYSSADVPSCCPDVTDDVKWQWKNGAFVSDTPSQARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O88017</accession>
    <name>O88017_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ordered locus">SCO6661</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35160">
        <property type="entry name" value="T35160"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630736.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031084.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6661"/>
    <dbReference type="GeneID" id="1102100"/>
    <dbReference type="KEGG" id="sco:SCO6661"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6767"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_11"/>
    <dbReference type="InParanoid" id="O88017"/>
    <dbReference type="OMA" id="EGMRFIP"/>
    <dbReference type="PhylomeDB" id="O88017"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="110"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="295"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA19940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="592" mass="65672" checksum="87DBB53316FCB495" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>P0A463</accession>
    <accession>P48954</accession>
    <name>RL11_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">SCO4648</name>
        <name type="ORF">SCD82.19</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Gen. Genet." volume="247" first="118" last="122">
            <title>Cloning, nucleotide sequence, and transcriptional analysis of the nusG gene of Streptomyces coelicolor A3(2), which encodes a putative transcriptional antiterminator.</title>
            <authorList>
                <person name="Puttikhunt C."/>
                <person name="Nihira T."/>
                <person name="Yamada Y."/>
            </authorList>
            <dbReference type="PubMed" id="7715599"/>
            <dbReference type="DOI" id="10.1007/BF00425829"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="D32254">
        <property type="protein sequence ID" value="BAA06986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB005915">
        <property type="protein sequence ID" value="BAA31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S54718">
        <property type="entry name" value="S54718"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628809.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974315.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A463"/>
    <dbReference type="SMR" id="P0A463"/>
    <dbReference type="STRING" id="100226.SCO4648"/>
    <dbReference type="GeneID" id="1100089"/>
    <dbReference type="KEGG" id="sco:SCO4648"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4719"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_11"/>
    <dbReference type="InParanoid" id="P0A463"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="PhylomeDB" id="P0A463"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104377" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="144" mass="15394" checksum="CCA5B3C53AB21C9C" modified="2005-03-15" version="1">MPPKKKKVTGLIKLQIQAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGWVIPVEITVYEDRSFTFITKTPPAAKMILKAAGVEKGSGEPHKTKVAKITRDQVREIATTKMPDLNANDLDQAEKIIAGTARSMGVTVEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>P35885</accession>
    <accession>Q9KXX5</accession>
    <name>GYRA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase subunit A</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyrA</name>
        <name type="ordered locus">SCO3873</name>
        <name type="ORF">SCH18.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Gene" volume="151" first="23" last="28">
            <title>Gene organization in the dnaA-gyrA region of the Streptomyces coelicolor chromosome.</title>
            <authorList>
                <person name="Calcutt M.J."/>
            </authorList>
            <dbReference type="PubMed" id="7828880"/>
            <dbReference type="DOI" id="10.1016/0378-1119(94)90628-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA65216" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="L27063">
        <property type="protein sequence ID" value="AAA65216.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628060.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029284.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P35885"/>
    <dbReference type="SMR" id="P35885"/>
    <dbReference type="STRING" id="100226.SCO3873"/>
    <dbReference type="GeneID" id="1099309"/>
    <dbReference type="KEGG" id="sco:SCO3873"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3946"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_11"/>
    <dbReference type="InParanoid" id="P35885"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="PhylomeDB" id="P35885"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <feature type="chain" id="PRO_0000145261" description="DNA gyrase subunit A">
        <location>
            <begin position="1"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="1">
        <location>
            <begin position="534"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA65216." evidence="3" ref="1">
        <original>D</original>
        <variation>V</variation>
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="857" mass="94583" checksum="4306FD52CE64C547" modified="2001-10-18" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>P46788</accession>
    <accession>Q9L0C4</accession>
    <name>RL18_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">SCO4718</name>
        <name type="ORF">SCD31.43</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-02" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and sequencing of the secY locus from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Loriaux A."/>
                <person name="Brans A."/>
                <person name="Dusart J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83011">
        <property type="protein sequence ID" value="CAA58133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S50002">
        <property type="entry name" value="S50002"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628877.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974252.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P46788"/>
    <dbReference type="SMR" id="P46788"/>
    <dbReference type="STRING" id="100226.SCO4718"/>
    <dbReference type="GeneID" id="1100159"/>
    <dbReference type="KEGG" id="sco:SCO4718"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4789"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_11"/>
    <dbReference type="InParanoid" id="P46788"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="PhylomeDB" id="P46788"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131355" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA58133." evidence="2" ref="1">
        <original>R</original>
        <variation>V</variation>
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="127" mass="13579" checksum="37E69543D4DEE8C7" modified="2001-10-18" version="3">MAYGQKILKGDAYKRAAIKRRHIRIRKNLSGTAERPRLVVTRSNRHIVAQVIDDIKGHTLASASTLDTSIRGGEADKSAQAKQVGALVAERAKAAGVEAVVFDRGGNQYAGRIAALADAAREAGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL1</accession>
    <name>Q8CJL1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7035</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733722.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031393.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7035"/>
    <dbReference type="GeneID" id="1102473"/>
    <dbReference type="KEGG" id="sco:SCO7035"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7139"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_11"/>
    <dbReference type="InParanoid" id="Q8CJL1"/>
    <dbReference type="OMA" id="RANDTPW"/>
    <dbReference type="PhylomeDB" id="Q8CJL1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="14"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="50494" checksum="3E2F546D8FBD85E3" modified="2003-03-01" version="1">MTDTPTQLFLGGAWADAADGAVMPVDDPATGEILAHVADAGPKDARLAEEAAVQAQEEWARAAPRARSEILRRAYEIVLERTDALARLMTSEMGKPLAEARGEVAYAAEFFRWFSEEAVRIDGGHGVLPDGRNRMLLSRRPVGPCLLITPWNFPLAMGTRKIGPAVAAGCTMVLKPAPQTPLSSLALAAILKEAGLPDGVLNVVTTSRAGEVCEPLLRGGRIRKLSFTGSTAVGRLLLAQCADTVVRTSMELGGNAPFVVFDDADLDAAVDGAMVAKMRNMGEACTAANRFFVHRSVAGEFADRLARRMGALVVGPGTGDGVDVGPLIDAAGRAKVEELVADAVERGARVLVGGTTPEGPGCFYPPTVLTDVAPESRLMATEIFGPVAAILTFDDEDEVVRRANDTPWGLVGYVFTEGLDRALRVSERLDVGMVGLNTGLVSNPAAPFGGVKQSGLGREGGRVGIEEFLEYQYVALPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJN6</accession>
    <name>Q8CJN6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6275</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAD55506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733695.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030787.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6275"/>
    <dbReference type="GeneID" id="1101716"/>
    <dbReference type="KEGG" id="sco:SCO6275"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6391"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_8_11"/>
    <dbReference type="InParanoid" id="Q8CJN6"/>
    <dbReference type="OMA" id="LGGCTQK"/>
    <dbReference type="BioCyc" id="MetaCyc:SCO6275-MON"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071770">
        <property type="term" value="P:DIM/DIP cell wall layer assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="920"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2657"/>
            <end position="2732"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4403"/>
            <end position="4478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4099"/>
            <end position="4118"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="955"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2692"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="4438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD55506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="4557" mass="476022" checksum="0BA04B4B03DC4E18" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJP0</accession>
    <name>Q8CJP0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6165</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAD55373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34678">
        <property type="entry name" value="T34678"/>
    </dbReference>
    <dbReference type="PIR" id="T35472">
        <property type="entry name" value="T35472"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733690.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6165"/>
    <dbReference type="GeneID" id="1101606"/>
    <dbReference type="KEGG" id="sco:SCO6165"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6274"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_2_11"/>
    <dbReference type="InParanoid" id="Q8CJP0"/>
    <dbReference type="OMA" id="RERLMIV"/>
    <dbReference type="PhylomeDB" id="Q8CJP0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD55373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="125" mass="14357" checksum="A48FFB7B56AC2268" modified="2003-03-01" version="1">MNNQIIGDRDTRLPPLSPEDLAALRDNLREQRLFREEQLRQIAAYPSRTDESIQRRSAAQTEVRVKLAASARMVLADVEAALDRIAEGRYGNCHLCRRAIDRERLVIVPQARYCARCQQVREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJP9</accession>
    <name>Q8CJP9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative UDP-N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5998</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAD55243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733681.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972925.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5998"/>
    <dbReference type="GeneID" id="1101440"/>
    <dbReference type="KEGG" id="sco:SCO5998"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6097"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_1_11"/>
    <dbReference type="InParanoid" id="Q8CJP9"/>
    <dbReference type="OMA" id="NYMVQDL"/>
    <dbReference type="PhylomeDB" id="Q8CJP9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD55243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="509" mass="56455" checksum="3A364191E1EF0156" modified="2003-03-01" version="1">MADDYLVRIGRLIRDARQHRGWTQSQLAEALNTSQSAVNRIERGNQNISLEMIARIGEALDSEIVSLGYAGPMHLRVVGGRRLSGAIDVKTSKNACVALLCASLLNKGRTVLRRVARIEEVYRLLEVLNSIGVRTRWINDGTDLEIVPPAELDMEAIDAEAAVRTRSIIMFLGPLLHRMERFRLPYAGGCDLGTRTIEPHMIALRRFGLDVAATEGHYHAVVDRQVRPDRPIVLTERGDTVTENALLAAARHDGVTVIRNASSNYMVQDLCFFLEALGVRVEGIGTTTLTVHGMPVIDADVDYSPSEDPVEAMSLLAAAVVTESELTVRRVPIEFLEIELAVLEEMGLDHDRTPEYFADNGRTRLVDLTVRPSKLEAPIDKIHPMPFPGLNIDNVPFFAAIAASAQGQTLIHDWVYDNRAIYLTDLNRLGGRLQLLDPHRVLVEGPTRWRAAEMMCPPALRPAVVVLLAMMAAEGTSVLRNVYVINRGYEDLAERLNSIGAQIEIFRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJS7</accession>
    <name>Q8CJS7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4833</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD55217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733649.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974139.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4833"/>
    <dbReference type="GeneID" id="1100274"/>
    <dbReference type="KEGG" id="sco:SCO4833"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4909"/>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_2_3_11"/>
    <dbReference type="InParanoid" id="Q8CJS7"/>
    <dbReference type="OMA" id="FPFTLCA"/>
    <dbReference type="PhylomeDB" id="Q8CJS7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD55217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="24965" checksum="04412CAA37443E5E" modified="2003-03-01" version="1">MSHAAAFRALHHGRVPDDPLVLPGPWDAASARVCVEAGFPALATPSAGVAASLGYEDGQTPADEMFAAVARIVRAVDVPVSADVEDGYGLAPKELVERLLEVGVVGCNLEDSTDGGLKDPAEHAEWLAGVREEAGDRLFLNARIDTFIRGVDDPGAAIERAAAYVAAGADCVYPIAAPTALLPLLRSGIQGPVNVFARPGQGPAPAELGGLGATRITFGPGLQRHAEQSVREAAAGLAGRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWC5</accession>
    <name>Q8VWC5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T5orf172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.37</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639809.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039603.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095073"/>
    <dbReference type="KEGG" id="sco:SCP2.37"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8329"/>
    <dbReference type="HOGENOM" id="CLU_1401734_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="194" mass="21153" checksum="BC00A9E15B43F523" modified="2002-03-01" version="1">MTQSRKPSEVVYLLGAEGLDLVKIGTTTDVERRVRTMQTGLPLTLSVLWTCEGGRALEGALHQEFREHNRRGEWFDLTSLGDPVAVVSETVRRLAPGLGLPIPPPRVSPDLALTPVAPTIPGCVRLERTLTARMLAWFECEDFGLPPSASKPVMLYRTVQYDAKGDVLAVTQTLVGDGHEQPEGFELPPVQGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RY1</accession>
    <name>Q93RY1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6291</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630389.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030798.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6291"/>
    <dbReference type="GeneID" id="1101732"/>
    <dbReference type="KEGG" id="sco:SCO6291"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6406"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_1_2_11"/>
    <dbReference type="InParanoid" id="Q93RY1"/>
    <dbReference type="OMA" id="GWCQGRM"/>
    <dbReference type="PhylomeDB" id="Q93RY1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017224">
        <property type="entry name" value="Opine_Oxase_asu/HCN_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037495">
        <property type="entry name" value="Opine_OX_OoxA/HcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="511" mass="52680" checksum="BB449F1BD8E10ECE" modified="2001-12-01" version="1">MTEPADLVVVGAGPAGMAAAATALAGGLRVALLDSGTALGGQYWRHPPEHARAAVPTDDLHHGLDRYRALCRALAAHRTAGRLDLRLEHHAWSAVREGDGFAVHAADRREAPRETAVVLRAPRLLVATGAYDRQLPFPGWDLPGVLTAGGMQALLKGGSVAAGSRVALGGTGPFLLPVAAGLAARGVEVVAVCEAAHPRAWLRHPGPLLSNPDKWAEGAGYAATLVRHRVPVRPRTAIVAAEGGERVTSVRIASLAPDGSPRPGTERRVEVDAVGVGWGFAPQLDLLVPLGASLTDSADGNAVVAVDRGQRTTVPGLYAAGETCGVGGAALAVNEGRLAAASVLADARATTVPANGRLAALRSAVDRQRAFARAMALAHPVPPAWSSWLTDETVVCRCEEVTAGAIRTARADGAPDHRQIKQLTRAGMGWCQGRMCGPAVHCLTARHRAYEPAERLVATPVTLGALADLDEDPPVSTASPVSAASPVSAASPVSATSTEPTDSSETDKECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACT7</accession>
    <name>Q9ACT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.216</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639822.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039514.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095294"/>
    <dbReference type="KEGG" id="sco:SCP1.216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8156"/>
    <dbReference type="HOGENOM" id="CLU_1546678_0_0_11"/>
    <dbReference type="OMA" id="TDHATHD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="18970" checksum="7D72570A629F08B9" modified="2001-06-01" version="1">MNSSGPARGRHDHLMRGGFGDIHTTTLFPFLTPADVDSLHQAARAVDEARRDGNTVDWEWFPEHAAFSGRQVGTPIILGLDVAGPAEEGDQLEFLLQVVWTDQGRLAVDAVVNVACWCRTDHATHDVDALTVVVSDETSLPEAFWATATRLTGWLAEPHDADYWRAKAGLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD71</accession>
    <name>Q9AD71_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.77c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639652.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039378.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095156"/>
    <dbReference type="KEGG" id="sco:SCP1.77c"/>
    <dbReference type="HOGENOM" id="CLU_1255349_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="23266" checksum="9E227C0A93DF6BBC" modified="2001-06-01" version="1">MSRRPDGLPPDSGRIFLAGLALVIVLAVVRPAAERSDVAREFGPEYAGPLRTMRRTDHVSSTSRRGLRQQHRHDVVFVVLGPFNERVQHSVAFQDLPGEAFHQLGVGAGGGQVPPGRPARGDDARPGRCGCLLGVGERVVDRGDGGMLSGVFPGLDRELPRDLRAGHAIVLERESEQEHAVVDALRPPAAVALGRGGGLSLQGPSPGGTAARRGGRSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADF7</accession>
    <name>Q9ADF7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6106</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630214.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030655.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6106"/>
    <dbReference type="GeneID" id="1101547"/>
    <dbReference type="KEGG" id="sco:SCO6106"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6209"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016513_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADF7"/>
    <dbReference type="OMA" id="VEFDGTW"/>
    <dbReference type="PhylomeDB" id="Q9ADF7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="180"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="295"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="557" mass="58876" checksum="137E3500BD5EE166" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADI4</accession>
    <name>Q9ADI4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6079</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630187.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030637.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6079"/>
    <dbReference type="GeneID" id="1101520"/>
    <dbReference type="KEGG" id="sco:SCO6079"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6181"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092072_1_0_11"/>
    <dbReference type="OMA" id="MGRLSHD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="19933" checksum="2C1F84B0CF345DD9" modified="2001-06-01" version="1">MTSSFEFPTYPARLSDAERDKALSVLRDGVAMGRLSHDTFIRRMELALAARRLEELAVLTADLPTENRLSRLVFGTVEAVSGFGVRLGRAWRAERLPKLLLPHPGAGHPLRIGRDPASGLRLSHETVSRVHAELSRQGGMWVLRDLGSTNGTTVNGRRVIGAAVVHEGDQIGFGGMSFRLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADK1</accession>
    <name>Q9ADK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974010.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4966"/>
    <dbReference type="GeneID" id="1100407"/>
    <dbReference type="KEGG" id="sco:SCO4966"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5046"/>
    <dbReference type="eggNOG" id="ENOG5033B4I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121826_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ADK1"/>
    <dbReference type="OMA" id="YCTVRSQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="14276" checksum="D0F84EFD1236359E" modified="2001-06-01" version="1">MSTASTRTPQGRYGRSSDEQADRTLKIVGAVLGALLLALIGWFGYHYVGQNKISGELIGFELAEDSVQVHLEVRKDAGVTGYCTVRSQAEDGDEVGRADFRFDGDDTRIDKVVTLRTKAAGTTAELLGCHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK94</accession>
    <name>Q9AK94_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transport system transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1368</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625652.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027750.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1368"/>
    <dbReference type="GeneID" id="1096791"/>
    <dbReference type="KEGG" id="sco:SCO1368"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1376"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060907_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AK94"/>
    <dbReference type="OMA" id="GDASYSH"/>
    <dbReference type="PhylomeDB" id="Q9AK94"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="38002" checksum="632B05704DEFB52B" modified="2001-06-01" version="1">MFVAWRDLKFAKGRFALMGTVIVLITLLVGLLSGLTAGLGRQNTSAITDLPADRIAFRAPGGGGDLSYADSTVTERQWRQWSEAPGVEAAEPLGITTTKATAGDRSAGVSAFGVRPGSRLAPADGIDDGAAVLSTTAADDLGVRRGDSFALAGQRLRVAEVRGDAFFSHTPVVWTTLDVWRKAAPPTGGDDGATGGRGGDGPTGGRSGDGPTATVIALRTTSAADVAAVDEKAGTTTVATADSLSAIGSYTSENGSLQLMRGFLFAISALVVGAFFTVWTIQRSGDVAVLKALGASTAGLLKDALGQAVVLLVGGTLLGTGAAAALGALAAGSSVPFLLTPATVLLPAAVMVLLGALGAALSIRRITSVDPLTALGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF0</accession>
    <name>Q9EWF0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4919</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC18716.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629072.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029948.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4919"/>
    <dbReference type="GeneID" id="1100360"/>
    <dbReference type="KEGG" id="sco:SCO4919"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4998"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_11"/>
    <dbReference type="InParanoid" id="Q9EWF0"/>
    <dbReference type="OMA" id="CLMAVGA"/>
    <dbReference type="PhylomeDB" id="Q9EWF0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="356"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC18716.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="475" mass="49816" checksum="A4B4718FB42B581D" modified="2002-10-01" version="2">MIIGGGPGGYEAALVAAQLGAEVTVVDCDGLGGASVLTDCVPSKTLIATAEVMTTFDSSYEELGIIVADDTPPMEQAARVVGVDLGKVNRRVKRLALAQSHDITASVTRAGARVMRGRGRLEGMQGLDGSRKVVVRAADGSEETLTADAVLIATGGHPRELADARPDGERILNWTQVYDLEELPEELVVVGSGVTGAEFAGAYQALGSRVTLVSSRDRVLPGEDPDAAAVLEDVFRRRGMNVMSRSRAQSVKRVGDRVEVTLSDGRVIGGSHCLMAVGAIPNTEGMGLEEAGVRLKDSGHIKTDRVSRTSAPGVYAAGDVTGVFALASVAAMQGRIAMYHFLGDAVTPLNLKTVSANVFTDPEIATVGYSQADVDAGKIDARVVKLPLLRNPRAKMQGIRDGFVKIFCRPGTEIVVGGVVVAPRASELIHPISIAVDNNLTVEQIANAFTVYPSLSGSIAEVARQLHTRKAGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWK9</accession>
    <name>Q9EWK9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7784</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flavin oxidoreductase frp family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631814.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031907.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1103221"/>
    <dbReference type="KEGG" id="sco:SCO7784"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7901"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWK9"/>
    <dbReference type="OMA" id="GMCLGYP"/>
    <dbReference type="PhylomeDB" id="Q9EWK9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02146">
        <property type="entry name" value="NfsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016446">
        <property type="entry name" value="Flavin_OxRdtase_Frp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43425">
        <property type="entry name" value="PTHR43425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005426">
        <property type="entry name" value="Frp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="28331" checksum="9E1DBD8384C92EB9" modified="2001-03-01" version="1">MNIIWNEQIEALLAHRSVRAFTDEPLPDGALETVVAAAQSASTSSNLHQWSLVAVSDPETKAELARLTHGAEFTGFDFVAQAPSVLLWIADMSRSHAISVEQGGKPVVTDYVDAFLMASVDAALAAQNGLVAAEAIGLGGVYLGSLRNHAKELSDLIGLPAYAYVVFGMAVGTPDPHRPSAVHPRPAQDVVLHRERYRTRPVEEWIEDYETAFKAFRAEYGLRDKTWSHSVAVSTGLDYMDGRENLRRTLEERGYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWY4</accession>
    <name>Q9EWY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1142</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625435.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027605.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1142"/>
    <dbReference type="DNASU" id="1096565"/>
    <dbReference type="GeneID" id="1096565"/>
    <dbReference type="KEGG" id="sco:SCO1142"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1139"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_1_2_11"/>
    <dbReference type="InParanoid" id="Q9EWY4"/>
    <dbReference type="OMA" id="FWPRYPG"/>
    <dbReference type="PhylomeDB" id="Q9EWY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="38959" checksum="E449E25D1C86F066" modified="2001-03-01" version="1">MNNTREVEVVVIGAGQAGLAAAYHLRRTGFEPERDFVVLDHAPGPGGAWQFRWPSLTYGKVHGMHALPGMELTGADPARPSAEVVSGYFAEYERTFDLRVRRPVDVRAVREGTNGRLLVETSAGSWSTRALINATGTWDRPFWPRYPGQETFRGRQLHTAQYAGPEEFTGLRVIVVGGGASGTQHLLEIAPYAAATTWVTRRPPVFREGPFDEEAGRAAVALVEERVRQGLPPKSVVSVTGLPLNDAVRAGLESGVLDRQPMFDRITPEGVEWDGGRRVAADAILWATGFRAAVDHLRPLRLREAGGGIRVEGTRAVADPRIHLVGYGPSASTIGANRAGRAAVRDIRRLLAEEEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX25</accession>
    <name>Q9EX25_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625311.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027520.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1015"/>
    <dbReference type="GeneID" id="1096438"/>
    <dbReference type="KEGG" id="sco:SCO1015"/>
    <dbReference type="HOGENOM" id="CLU_2119668_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="11847" checksum="FEF4DA9D32C6F246" modified="2001-03-01" version="1">MISDQEAQAARITIPAMSTPPCLGPSATAPAADAVPLEPTVSPARVAPDLTGPRRPAESDRRPGLGHTVTAGRRIVDRSAPGCGETMRHRSPTARRRPRTVLSTARSPAVHSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2N1</accession>
    <name>Q9F2N1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SCO3119 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3119</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627337.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975694.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3119"/>
    <dbReference type="GeneID" id="1098553"/>
    <dbReference type="KEGG" id="sco:SCO3119"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3185"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9F2N1"/>
    <dbReference type="OMA" id="GDMGRQA"/>
    <dbReference type="PhylomeDB" id="Q9F2N1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="439" mass="46170" checksum="164ED5464F772506" modified="2001-03-01" version="1">MTTTGEDHEPARGGPWWWDRRRGAVLDVSLGVVSALECAAEGVPFARDAGIPPAMGVVFGLLAGSMLVVRRKWPIAVVLVALAITPAEMGFLMGVVGLYTMAASELPRRIIGALAGMTFLGTLVVTFVRLGQDMARDGLDLGDWFLPFASIATSLGMTAPPLLLGLYVGQRRRLMESLRERADSLERELQLLAERAEERAEWARGEERTRIAREMHDVVAHRVSLMVVHAAALQAIARKDPEKAVKNAALVGDMGRQALTELREMLGVLRSGGGGARAERASVPLAAVGVAAAAAASRAAEDGESSSEGPCLSELDELIGQSEAAGMVVNLSVEGAERAYAAEVESTAFRVVQEALTNVHKHAAGAKTHVRLAHRVSEIAMQVENEPPPEVSSASSARLPSGGNGLVGMKERVAALGGVFVSGPTDAGGFRVSAVIPAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2V2</accession>
    <name>HTPX2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protease HtpX homolog 2</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpX2</name>
        <name type="ordered locus">SCO4609</name>
        <name type="ORF">SCD39.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628771.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974338.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F2V2"/>
    <dbReference type="STRING" id="100226.SCO4609"/>
    <dbReference type="GeneID" id="1100049"/>
    <dbReference type="KEGG" id="sco:SCO4609"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4681"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_3_1_11"/>
    <dbReference type="InParanoid" id="Q9F2V2"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="PhylomeDB" id="Q9F2V2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000138893" description="Protease HtpX homolog 2">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <sequence length="287" mass="31168" checksum="087F7C8CCADBE439" modified="2001-03-01" version="1">MHRRHNGLRTAVLLGGLSALIIVIGSFFGRAGLVVAVLVALGTNAYAYWNSDKLALRAMRARPVSEFEAPALYRMVRELSTQARQPMPRLYISPTDAPNAFATGRNPRNAAVCCTEGIMRLLDERELRGVIGHELSHVYNRDILISSVAGALASVIMFLVNFAWLIPVGRSNDDDGPGLLGMLLIMLLGPLAATVIQLAISRSREYEADASGAQLTGDPLALAGALRKLELGTKQLPLPPEPRLETASHMMIANPFRPGQGISKMFSTHPPMAERIARLEKMAGRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F300</accession>
    <name>Q9F300_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4347</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628517.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029593.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4347"/>
    <dbReference type="GeneID" id="1099787"/>
    <dbReference type="KEGG" id="sco:SCO4347"/>
    <dbReference type="eggNOG" id="ENOG50340CG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121779_0_0_11"/>
    <dbReference type="OMA" id="QKVIGPC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="16111" checksum="A599B407DF803FB1" modified="2001-03-01" version="1">MTHNHQAEAETRIRSAMQRLLAGSVPDGLKCDVKSLCTLAGVPRATLYRTYPHLKAEFDRQRTAAQDAGQQPDTRLAQIERLKAEVATLRERLSRKNVELDALKEFQVTALSRIAAQQDAITSLRRELEAAQERRLRPVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L0</accession>
    <name>Q9F3L0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629401.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F3L0"/>
    <dbReference type="STRING" id="100226.SCO5255"/>
    <dbReference type="GeneID" id="1100696"/>
    <dbReference type="KEGG" id="sco:SCO5255"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_11_0_11"/>
    <dbReference type="InParanoid" id="Q9F3L0"/>
    <dbReference type="OMA" id="WWVLGDN"/>
    <dbReference type="PhylomeDB" id="Q9F3L0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="16158" checksum="6BC98BDF86476A80" modified="2001-03-01" version="1">MMPEQLSQETERARGALPFGPAEVTGPSMVPTLHHGDVLLVHWGARVRPGDVVVLRHPFQQDLLVVKRAAERRGAGWWVLGDNAFAGGDSTDYGVVPQDLVLGRVRFRYRPPRAGQRSPLAVVRWALSAVRPVPADRSASRRLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBI4</accession>
    <name>Q9FBI4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5175</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030097.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5175"/>
    <dbReference type="GeneID" id="1100616"/>
    <dbReference type="KEGG" id="sco:SCO5175"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5258"/>
    <dbReference type="eggNOG" id="ENOG5033Q7Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036901_0_0_11"/>
    <dbReference type="OMA" id="AAWCAHL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="35907" checksum="0107EB9757674F9F" modified="2001-03-01" version="1">MKGLLHRHRELCERAVDPLEIVAGLEAHGVTDRTAARFRHRDVFSLAEEMYARVPRDGDAPAPPEDGPTPRPGGPRAAGSVLLALLPGVLCAAAVAGLRLTDGRPRLIAAAVGVLAVSLALGAALRRGPLTAATRTTSTWTCWLLGYALLGDGLLRTAVSGGPDGLPDGSPDGAWPVTLAPVLALTLSYAPAAGCAHLFAAGARRKLSSSRGLTDFSASVRPLLLGAFALYLGALAALLTLTGAVLGEPADWSQGLSLGALLLLARLLGVHGHTHAGPFVLTATAAAEAAALATVFAGRLPGCGLLSAPVEALVAACGPAGVPTAACGIGALALLVHACRRLTRASAHASTERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBK3</accession>
    <name>Q9FBK3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5155</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629303.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030089.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5155"/>
    <dbReference type="GeneID" id="1100596"/>
    <dbReference type="KEGG" id="sco:SCO5155"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5238"/>
    <dbReference type="eggNOG" id="ENOG50337FI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061390_3_0_11"/>
    <dbReference type="OMA" id="DAGFWSH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329060" evidence="1">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="25138" checksum="A8FE17D40DD2B1A8" modified="2001-03-01" version="1">MTPRRRIRRAALLGAVCALAVTGAGLTGCSSEDPDAGTNGLGKLSADKIQAKAGTAAQAARTVRLHGSVEAAGSTYTLDMRLKADGGTGSVAAEGTTFGLLRVGEQLFLKADAGFWSHDGGDAKAADKLAGKYVKVPQSDPVYKKFSGFTDKDVLLGGLLTLHGTVKTDGRHEQAGVRTIRITGDDGAGGSLDVSLEGTPYPLRLVRAGSAGTIGFSDWNKDFALEQPAKDDTLDYGKQLPSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBN0</accession>
    <name>Y5049_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative NADH dehydrogenase/NAD(P)H nitroreductase SCO5049</fullName>
            <ecNumber evidence="1">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5049</name>
        <name type="ORF">SCK7.22c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family. HadB/RutE subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973928.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FBN0"/>
    <dbReference type="SMR" id="Q9FBN0"/>
    <dbReference type="STRING" id="100226.SCO5049"/>
    <dbReference type="GeneID" id="1100490"/>
    <dbReference type="KEGG" id="sco:SCO5049"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5129"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084441_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBN0"/>
    <dbReference type="OMA" id="LMVVNIG"/>
    <dbReference type="PhylomeDB" id="Q9FBN0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01204">
        <property type="entry name" value="Oxidoreductase_RutE_HadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072732" description="Putative NADH dehydrogenase/NAD(P)H nitroreductase SCO5049">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01204"/>
        </source>
    </evidence>
    <sequence length="196" mass="21473" checksum="F29AF0C8830F954B" modified="2001-03-01" version="1">MSLVLDPAAQDLLFREARTANTFTDEPVTDEQVQAIYDLVKYGPTAFNQSPLRITLVRSPEARERLVAHMAEGNRPKTAAAPLVAILSADNEFHEELPELFPHFPAAKDAFFSERPVREGAATLNAALQAAYFIVGVRAAGLAAGPMTGLDFEGVRKEFLDDDHTPLMVVNIGRPGPDAWFPRSPRLAYDQVVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC45</accession>
    <name>Q9FC45_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7038</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631100.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7038"/>
    <dbReference type="GeneID" id="1102476"/>
    <dbReference type="KEGG" id="sco:SCO7038"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7142"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392678_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC45"/>
    <dbReference type="OMA" id="YRYGMET"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="760" mass="82561" checksum="21408144AEB61B2D" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL5</accession>
    <name>Q9FCL5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7799</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631830.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7799"/>
    <dbReference type="GeneID" id="1103237"/>
    <dbReference type="KEGG" id="sco:SCO7799"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7914"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="InParanoid" id="Q9FCL5"/>
    <dbReference type="OMA" id="FIWLLQM"/>
    <dbReference type="PhylomeDB" id="Q9FCL5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17834" checksum="79B7F04D864E7BF4" modified="2001-03-01" version="1">MQALTARAGHATYTRPHGIRHLFAAYDRHVINGILHRVRTGMQWRYLPERYGPRKTLYERHRRWPAVRTWERLLQKVQAQVDAAGGLDWDVSVDTTSVRGHQHAAGVRKAPPPAASKGAAAMAHRSGRSGARLCARLVEVVQEVRRSVPPEEASPPRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3H4</accession>
    <name>Q9K3H4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1266</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625553.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027680.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1266"/>
    <dbReference type="GeneID" id="1096689"/>
    <dbReference type="KEGG" id="sco:SCO1266"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1266"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="InParanoid" id="Q9K3H4"/>
    <dbReference type="OMA" id="NLRGYQN"/>
    <dbReference type="PhylomeDB" id="Q9K3H4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="8"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB99146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="422" mass="43392" checksum="18C5DE800028FA2C" modified="2000-10-01" version="1">MTGARPDVAVTGIGLVTPAGTGREATWDGVCAGRPTARHVPELKGLPVDFACLVPDFSPRDHVPGSRPWQYDRFTQFALHAALEAVSDAGLDPADWDGDRVAVVFGSSAGGTGTMLDQHRKLLELGTARVSPLLLPMFLPNMATGQLTIHLRARGPALCTVTACASGATAIGTALQLLRSGACDIAVAGASDAVVQPLWVTGFDRMGALSRRGDDPRAASRPFDTARDGFVMAEGGAALVLEPASAARARGRPGYALLAGYGASSDAHHPVAPDPESKGAALAVRRALDDAGARPADVQHINAHGTSTPLNDAAEARLIRRLFPHQPSVTSVKGTLGHLLGAAGAVEAAITALSVAHGRVPPVANLEKQEGDAEINAVTGTSRAQPVDLALSHSFGFGGHNAVLAFRSCPTEPAREPAAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M5</accession>
    <name>Q9K3M5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1035</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625330.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027533.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1035"/>
    <dbReference type="GeneID" id="1096458"/>
    <dbReference type="KEGG" id="sco:SCO1035"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1030"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087283_0_0_11"/>
    <dbReference type="OMA" id="NQYAPFY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032349">
        <property type="entry name" value="DUF4865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16157">
        <property type="entry name" value="DUF4865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB96020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="21492" checksum="67E9E03BD0205CA5" modified="2000-10-01" version="1">MHAMQYAFTLPADYPMDVIRERVARTGHLLDDWPGLGLKAYLVRERGKDGSPVNQYAPFYLWHTVEGMNSFLWEGAFQRPTDDFGRPAVRQWTGLAYEEGGAAGSPARHAVLRRHRVPEGVPLSEVAADAVRRTGRLAAMGGALLAAAVVDTGRWELAHFSLHAGEAPDGVEGEVFQVLHLSVPGRSLLPRGRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXP0</accession>
    <name>Q9KXP0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1510</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625790.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977316.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1510"/>
    <dbReference type="GeneID" id="1096936"/>
    <dbReference type="KEGG" id="sco:SCO1510"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1519"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_8_0_11"/>
    <dbReference type="InParanoid" id="Q9KXP0"/>
    <dbReference type="OMA" id="SKAPDPC"/>
    <dbReference type="PhylomeDB" id="Q9KXP0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="121"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="29486" checksum="45B9221930A3EE0F" modified="2000-10-01" version="1">MVTQEQRRRQLAREKFLRQQQRRTSARRKARMRNAAIASVLGVILIGSVALYTTGVVLGDDDDKTNAGAEVTPSASAPSKAPDPCDKPADGKVKTQTWKKEPAMTVDKSAKYTMKLATTCGDIDLALKADAAPHTVNSFDFLAGKGYFDHTKCHRLTTEGIYVLQCGDPTAQGNGGPGYNIPDENLKDKSLKDNVYPAGTVAMANTGQPDSGGSQFFLVYQDSQLPPSYTPFGTVSKEGMTVLKKIASAGAQPADPTTGNTAPNATVVIDKATVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXP6</accession>
    <name>Q9KXP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625784.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1504"/>
    <dbReference type="GeneID" id="1096930"/>
    <dbReference type="KEGG" id="sco:SCO1504"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1513"/>
    <dbReference type="eggNOG" id="COG3903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_5_3_11"/>
    <dbReference type="InParanoid" id="Q9KXP6"/>
    <dbReference type="OMA" id="WVGCGRL"/>
    <dbReference type="PhylomeDB" id="Q9KXP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="750" mass="81840" checksum="469E5F417EDC8862" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY05</accession>
    <name>Q9KY05_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7333</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631387.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031593.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7333"/>
    <dbReference type="GeneID" id="1102771"/>
    <dbReference type="KEGG" id="sco:SCO7333"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7437"/>
    <dbReference type="eggNOG" id="COG3281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029675_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KY05"/>
    <dbReference type="OMA" id="CREAFCA"/>
    <dbReference type="PhylomeDB" id="Q9KY05"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="8">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB92879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="453" mass="49579" checksum="D5231A384808A06A" modified="2000-10-01" version="1">MPKTAPLRTRRGQLAEPMSSLGELLRQWLPRQRWFAGKDRPVAELGLLSMTELFPGCLHLLVHTGQGSVPSPGGAPPAGDCYQLLLGVREQPSPRLGRAIIGQVQDGPLAGRTVYDALHDPRTAQLLLERFRHPGKAGPLRFEADPARPVPGGLAPRLLDAEQSNSSLIYGDEFILKLFRRIQPGVNPDLEVPDALARQGCGRVPAPVAWMRTTHPYGATLGVLQPFLHGASDGWTLSLNALAAGDEFTVQAHELGQAMGDVHLALASAFPVGAPGENGRTAAAMTERLTAAAHCVPALQPFVPGLRAAFAALSTCDWGPPAQRIHGDLHLGQVLRAGRDWFVIDFEGEPSRPLAERRSAHSPVRDIAGMLRSFDYAARQRRPWRPEWARRCREAFCAGYAARAGWDPRKKHGLLRAYETDRAVYEVLYEARHRPDWLPVPMAAIERLAVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY12</accession>
    <name>Q9KY12_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7326</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631380.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031588.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7326"/>
    <dbReference type="GeneID" id="1102764"/>
    <dbReference type="KEGG" id="sco:SCO7326"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7429"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_9_11"/>
    <dbReference type="OMA" id="ISAQHWT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="824" mass="87907" checksum="3339985FC4E5BE77" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYB9</accession>
    <name>Q9KYB9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6914</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630981.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031296.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6914"/>
    <dbReference type="GeneID" id="1102352"/>
    <dbReference type="KEGG" id="sco:SCO6914"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7021"/>
    <dbReference type="eggNOG" id="ENOG5031KHS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166918_0_0_11"/>
    <dbReference type="OMA" id="THTEMTV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="96" mass="10475" checksum="282BB65C9044D72E" modified="2000-10-01" version="1">MTSPEMTVGDLIDLLSGCDRSAPVRQAMNPFFPMAHRLAQVLQSVDETGRSVVYLAEGRDEDAQLGHLPPEVAIALTWQGPVQAPPRRPRRRAGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH7</accession>
    <name>Q9KYH7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626929.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028520.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2695"/>
    <dbReference type="GeneID" id="1098129"/>
    <dbReference type="KEGG" id="sco:SCO2695"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2751"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KYH7"/>
    <dbReference type="OMA" id="WIAKECP"/>
    <dbReference type="PhylomeDB" id="Q9KYH7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="27290" checksum="8AA505DD438C32AC" modified="2000-10-01" version="1">MRIEAVDWVEIPAGVVRRGTPADDIPLVAERYADTGVPVEWYLKEAPSTEIRLPAFRLARTPVTVGQWSVFAAATGRPVPTAPHDHPVTGVSWEAASAYCRWLGELSGDPGIRLPTEDEWERAARGDDGREFPWGDEYRTGLANLVDLGVGTTTPVGSFPDGAGPFGVLDMAGNVDEWTSTLYAPYPGAPAGVPLVEDWAFDPHITRGGAFRHDRDLARCARRHSAYEEDLAAIGVGLRLAAPAAGTSSASASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ00</accession>
    <name>Q9KZ00_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7529</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631573.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031727.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7529"/>
    <dbReference type="GeneID" id="1102967"/>
    <dbReference type="KEGG" id="sco:SCO7529"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7643"/>
    <dbReference type="eggNOG" id="COG3214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047003_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ00"/>
    <dbReference type="OMA" id="HDAMLRQ"/>
    <dbReference type="PhylomeDB" id="Q9KZ00"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB90887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="366" mass="39288" checksum="AA3163B5CDD1DC9F" modified="2000-10-01" version="1">MSVLDARSLNRAALARQLLLDRADHPVLGAVAHLGGMQAQEPQEPFVGLWSRLRDFAPRALDDLLTGRRVVRTHLMRRTVHLVTAEDVLAWRSRHDAMLRGRVLGTYRRELAGVDLDELAAAGRAVLADGEPRSMGDLARAVAARWPDAGPRPLGELLVAALIPTVQLPPRGLWRTRAGVRNAPVADWLGREVDPPAPPGTDPVGEELVRRYLAAFGPAASADLRAWCGLAGLPAAVAAVRGELVSFRDERGRELLDLPGAPRPDPGTPAPVRFLPAFDNAVLGYQDRGRIIDDPHRGLSVTGARFVLVDGRVSATWTVKDGTVTVAPLRRLTRPERAEVAAEGQALASFLSEGGSDRVTVGAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ65</accession>
    <name>Q9KZ65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3083</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627303.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975728.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3083"/>
    <dbReference type="GeneID" id="1098516"/>
    <dbReference type="KEGG" id="sco:SCO3083"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3144"/>
    <dbReference type="eggNOG" id="COG4760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074030_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ65"/>
    <dbReference type="OMA" id="VWIYLEM"/>
    <dbReference type="PhylomeDB" id="Q9KZ65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="307" mass="32332" checksum="E605CA0E644B393A" modified="2000-10-01" version="1">MRSRNPVFSRRGFSRDNGYAGFNAAPQAGGPAVATQANPYAQGAQGNPYAQPPAGNPYAQNPYAQPDQQFGAPPQAPATTGRMTMDDVVIRTASTLGVLVVTAALAWALLPVDDANISRSYGIGIGAALIGMVLALVQSFKRKPTPALILSYAAFEGVFLGVVSSVVDNRIADGAAMQAVIGTMAVFAGVLIAYKAGWIRVNRRFYGFVMAAALGFVFLMMVNLLFAVFGGGDGLGFRSGALGVVFGIVGIILGACFLALDFKQVEDGLAYGAPREEAWFAAFGLTLTLVWIYLEFLRLIAILNSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ74</accession>
    <name>Q9KZ74_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627294.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028752.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3074"/>
    <dbReference type="GeneID" id="1098507"/>
    <dbReference type="KEGG" id="sco:SCO3074"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3134"/>
    <dbReference type="eggNOG" id="ENOG50324Y8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124995_0_0_11"/>
    <dbReference type="OMA" id="RRGHRWW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="20200" checksum="4876015607FFB68C" modified="2000-10-01" version="1">MARGGQVGLARVAVVVRAGAAPLWWLGVFAAGIGVLVPGLTGRRIGVLAGAALFIVATAVVAWARRRRYTALAGSAARAGKHDVLQDRGVTVRDWRRGHRWWLLLAFLAALGSAFALPAAGGLLLAGCGAGLWLKAAWIGRREQAGDALLWVRVDWLADNAGRPAGKAVKAYRSTGIAAGDAAPGGARRKTPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L022</accession>
    <name>Q9L022_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7033</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631097.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031392.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7033"/>
    <dbReference type="GeneID" id="1102471"/>
    <dbReference type="KEGG" id="sco:SCO7033"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7137"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L022"/>
    <dbReference type="OMA" id="NFLEVTQ"/>
    <dbReference type="PhylomeDB" id="Q9L022"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="3">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="5">
        <location>
            <begin position="309"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="4">
        <location>
            <begin position="482"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="555" mass="59496" checksum="147EB4490F14A327" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L063</accession>
    <name>Q9L063_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2791</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627021.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028587.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1098225"/>
    <dbReference type="KEGG" id="sco:SCO2791"/>
    <dbReference type="HOGENOM" id="CLU_2262158_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB87228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="103" mass="10639" checksum="9316F1F38C1BD492" modified="2000-10-01" version="1">MRGNRSVDRCFFPSVPPAPACLPPTSARPLPGRDPLGTPQQQTARGGDGGQAEGRAGGAREGGAVPEERHRDEEAAERRPADEIGDAVPVGCAGRRVGGTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0A5</accession>
    <name>Q9L0A5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2441</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626684.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976365.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2441"/>
    <dbReference type="GeneID" id="1097875"/>
    <dbReference type="KEGG" id="sco:SCO2441"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2482"/>
    <dbReference type="eggNOG" id="ENOG5033246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460461_0_0_11"/>
    <dbReference type="OMA" id="WNEWLVR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB86106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="22226" checksum="A93E748AFFE16CC5" modified="2000-10-01" version="1">MMAAMPTGKRPAGPFTPRDFQLVLLRRMADHNPGPVEDARRELGASVAQMREANRRWQAMLRSPRSRSAAARYRSVLGEPESVAPRRIGDLECEARQWALPLWPGLRFEVLVADRGVVWNEWLVRAPGAPGPELRTLDDLTPWSCTVDEAARAFAPARPLQGSAPTRWGLAFTAPDREGVRHEVVAEFTWGLLQRTAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0U4</accession>
    <name>Q9L0U4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4500</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628664.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029696.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4500"/>
    <dbReference type="GeneID" id="1099940"/>
    <dbReference type="KEGG" id="sco:SCO4500"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4572"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056696_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0U4"/>
    <dbReference type="OMA" id="YPHVLGF"/>
    <dbReference type="PhylomeDB" id="Q9L0U4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB77291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="30855" checksum="3B8D66911C552A95" modified="2000-10-01" version="1">MTTAPPTPGTLTGVPALAPLLARGALLSPLKRPRPDADFPRTRLVLPGLRVDLARLAAYERVCGFATGADALPVTYPHVLGFPMAMRLMSGRGFPLPLLGLVHTSIGITRRAAMPATAEYELAVHVEGLAAHRRGTEATVVTEVRAGADLVWESRSTYLARHRTTAPPPAGEPPSGERDPLPVRAEWQLAGDVGRRYGAASGDRNPIHLHPLTARLFGFPRAIAHGMWTVARCLAEHGTPDAAVVRAEFRAPVLLPGTVAYGAGDGRFELRGGDGGRRLHLSGEVGPYPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0U5</accession>
    <name>Q9L0U5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4499</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628663.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029695.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4499"/>
    <dbReference type="GeneID" id="1099939"/>
    <dbReference type="KEGG" id="sco:SCO4499"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4569"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_2_11"/>
    <dbReference type="InParanoid" id="Q9L0U5"/>
    <dbReference type="OMA" id="MNFAWAG"/>
    <dbReference type="PhylomeDB" id="Q9L0U5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB77290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="25489" checksum="2A7A4B7D88C44804" modified="2000-10-01" version="1">MGAGKTKRMPRAVREQQMLDAAVSVFGRRGYMAASMDEIAELAGVSKPLVYLYLNSKDDLFSACVDREARALTEAVRAGVRPGLSADGQLWSGLRAFFTHTARHPDAWRVLHLHARTHGERFAAEVAAMREEIVAFVTQLIAAAARDAHRDPHLAEGEVAGLAEALVGAAESLADWAGATEGVTAKQAAATLMNFAWAGLGDLMAGRPWSAPEEPGPEEPAPVAERAPQEEPASVVQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L137</accession>
    <name>Q9L137_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sensor histidine-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7422</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631471.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031653.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7422"/>
    <dbReference type="GeneID" id="1102860"/>
    <dbReference type="KEGG" id="sco:SCO7422"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7532"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
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    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176811" evidence="3">
        <location>
            <begin position="37"/>
            <end position="543"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
            <begin position="249"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB76341.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="543" mass="56857" checksum="DDB021F19606E559" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1E8</accession>
    <name>Q9L1E8_STRCO</name>
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        <submittedName>
            <fullName evidence="6">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5457</name>
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    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030260.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5457"/>
    <dbReference type="GeneID" id="1100897"/>
    <dbReference type="KEGG" id="sco:SCO5457"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5541"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039404_3_1_11"/>
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    <dbReference type="PhylomeDB" id="Q9L1E8"/>
    <dbReference type="UniPathway" id="UPA00219"/>
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    </dbReference>
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        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0018104">
        <property type="term" value="P:peptidoglycan-protein cross-linking"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="416" mass="44781" checksum="730956DE760254BD" modified="2000-10-01" version="1">MRHVHERARRAGAALAALLTWAGLLAGATGCTSDGGGVGSGIGSGIGEMFGKQPAAEDVIRVTPDDGSKAVRPDGKLSVRVPDGRLESVRVVRSQDAQETPVPGRISEDGLSWRPDDGRLALAAKYTVDAVALDGGGHRSARHTTFTTQVPEERFIAYVAPENRSVVGTGMIVSLEFNREITDRAAVERAVTVTAEPAAEIRPHWFGKDRLDFRPKTYWKPGTEVIVDLDLRDVEGAKGVYGLQHKKVAFTVGRSQVSRVDAVERTMQVRRDGTLLATVPITAGAPTTPTYNGRMVITEMLEVTRMNSRTVGFGGEYDIPDVPHAIRLTSSGTFLHGNYWAPADTFGRANVSHGCVGLRDDKGGGSDTPAGWFFDRSLIGDVVEVVHSKDRTVAPDNGLGGWNMKWKEWKAGSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1H0</accession>
    <name>Q9L1H0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2607</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976192.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2607"/>
    <dbReference type="GeneID" id="1098041"/>
    <dbReference type="KEGG" id="sco:SCO2607"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2653"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_0_1_11"/>
    <dbReference type="InParanoid" id="Q9L1H0"/>
    <dbReference type="OMA" id="HDYQKKR"/>
    <dbReference type="PhylomeDB" id="Q9L1H0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="398" mass="42327" checksum="7C0C90FDE5EDE3BC" modified="2000-10-01" version="1">MTGNSFHVSGYGPDKAGWTRLFARDSMARRLDWPILLAAVALSLMGSLLVYSATRNRTELNQGDQYYFLTRHLLNTGIGLALMVATVWLGHRALRTAVPLLYGFSVFLILLVLTPLGSTINGAHSWIKLPGGFSLQPSEFVKITIILGMAMLLAARVDAGDRPHPDHRTVLQALGLATVPMLIVMLMPDLGSVMVMVIIVLGILLASGASNRWIFGLLGAGTAGALAVWQLGILDDYQIARFAAFANPALDPAGVGYNTNQARIAIGSGGLTGSGLFEGSQTTGRFVPEQQTDFVFTVAGEELGFLGAGLIIALLGVVLWRGCRIARSTPDLYGTVVAAGIVAWFAFQTFENVGMTLGIMPVTGLPLPFVSYGGSSMFAVWIAVGLLQSITVQRPMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1L2</accession>
    <name>Q9L1L2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5432</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629570.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030243.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5432"/>
    <dbReference type="GeneID" id="1100872"/>
    <dbReference type="KEGG" id="sco:SCO5432"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5514"/>
    <dbReference type="eggNOG" id="ENOG502ZCDR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1517060_0_0_11"/>
    <dbReference type="OMA" id="GWTYLVN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="19401" checksum="4F6881E147268877" modified="2000-10-01" version="1">MPEQDVTVGQLLLAEYESVKSEQRARIGFRDNLLYVTLAVVAAVIAATAQAEQPSMLLALPPVCLVLGWTYLVNDEKISAIGLYVRDDLGPKLAELAAHTSGFATFGWEAYHRSDTRRRSRKTIQTVIDLTAFCAVPLAALVVFWVNGDATRLLVVLSVLEALAVAGLAAQVVWYAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1N5</accession>
    <name>Q9L1N5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630950.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031265.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6880"/>
    <dbReference type="GeneID" id="1102319"/>
    <dbReference type="KEGG" id="sco:SCO6880"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6991"/>
    <dbReference type="eggNOG" id="ENOG502Z8K6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038805_0_0_11"/>
    <dbReference type="OMA" id="GLAEWWA"/>
    <dbReference type="PhylomeDB" id="Q9L1N5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="480" mass="51329" checksum="3634B82937C8E113" modified="2000-10-01" version="1">MKFPHRSRRGILLGLSLPQLVLVSCTLALLLMTVISTGLLGALVLAPLWAASGALVAIRRHGRSLIDWTPIVTRYAHRRRTGQTLWLARPVTRPRQDGVLHLPGTVASLKVVTPGDSANQAAAVHDPHQQTLTAIARVSSRAFALLDPTTQNHNVTSWGRALAGIARTGHVATVQVLERTVPDSGDTLTRHWTQNGQPQAPVAGQVYSELVASAGPAAAPHETYLAIALDLKAARRLINQAGGGLPGAFTVMQQTTASIAQTARNAGLMVTGWLSAREIAAVIRTAYDPGALAALQQWSETGRAEADPTAAGPVVQFEEDDRLATDSARHATYWVENWPRTEMGAGFLHGIMFTAGVRRSLSLIYVPQGLESALRDVQRKKAAIIADANERARRGQVDSEEDSVEYADVKARERQLIAGHADVALTGLVTVTAETDALLDAACAQIETHAVTSGVDLRRLTYQQPDAFALSALPLARTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1P6</accession>
    <name>Q9L1P6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6869</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630939.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031254.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6869"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="1102308"/>
    <dbReference type="GeneID" id="1102308"/>
    <dbReference type="KEGG" id="sco:SCO6869"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6981"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085736_0_0_11"/>
    <dbReference type="OMA" id="HEAGDVW"/>
    <dbReference type="PhylomeDB" id="Q9L1P6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="27284" checksum="AE6829232BB1A77F" modified="2000-10-01" version="1">MITVVIASRLREDRLDYLTAMHASLTRQSVPWEAVIALDGASPDRLPRQLAQDPRVDTLVLPRPVGAACARNLALTQVRTRYVNWADDDDEFTDDAMSVRLETLESTGVGWCAGWSEDQFRDGSTRLWRCPTPPGRHEAGDVWTFWKSPADTIPIGPTTILARTDLVRAAPMGGLVQGEDYCAALGVTALAPGILLPLPVYRYRKWGGQMTAQDGYDQLETAAREHAWAYGRSLRAVLRGGEDLVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1P9</accession>
    <name>Q9L1P9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6866</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630936.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031251.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6866"/>
    <dbReference type="GeneID" id="1102305"/>
    <dbReference type="KEGG" id="sco:SCO6866"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6978"/>
    <dbReference type="eggNOG" id="ENOG5030Q96">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709640_0_0_11"/>
    <dbReference type="OMA" id="GPMVRLQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="396" mass="42489" checksum="B094A785D08B1009" modified="2000-10-01" version="1">MTPANSPAPDSPLPTASALASKARDFRLRMAVIDCETDAALDRTRDRHGRTVHADAAAAARVHRDKAAVEAYATHLAPHAEALLDAARLALDELPPARHLTGWRAVLDGLASSAAEIRRALDRPTPPGSRAERAQHAALWPHLTAWADHSPIASNLADQRDGQHHQAPLTDEEQQLWTDRARAAQTRGALELTESWYAADGQPITLAYLGEDDDSTVVALRGDPGAPGWQVIGHFAHEYEAGKALPAPVPPGVLRSDLSRFNRPAPAPELSLQDLIRDVVEGHSAGDASNALLGAVQRGHAAGPMVRLQELLETSGQFANALETVRGRQIAARLSALGRQIEFLTREVEEAAEGLGATVAVLPPHRTPVLRARPRPAVDTTPPVPPPRADMTVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Q6</accession>
    <name>Q9L1Q6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6858</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630928.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031243.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6858"/>
    <dbReference type="GeneID" id="1102297"/>
    <dbReference type="KEGG" id="sco:SCO6858"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6968"/>
    <dbReference type="eggNOG" id="ENOG5032QCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214273_0_0_11"/>
    <dbReference type="OMA" id="GYHVDCD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="25517" checksum="D703DF98F9FB7CAE" modified="2000-10-01" version="1">MPRTTGRLLDIRRDPHAGELLARGGDVEAHSVLQRAGFVAVVRLHESYHRAPAGLTEDEESRLAIDAVGRLRAVGYHVDCDERFDTEARPASYPTLGASVSHLAERLREATDTAEAADILTELTAPHDGILAGFEETLGALAEFFNGLGDASDPYTARRLRYLADAYVRVIHSDLAHTREQLADRHTPHPGRRACTEQVPDHEPERSAVCACPPPPRALPAPAPPPVGATRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L200</accession>
    <name>Q9L200_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SCO2635</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626871.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028467.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2635"/>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="GeneID" id="1098069"/>
    <dbReference type="KEGG" id="sco:SCO2635"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2682"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L200"/>
    <dbReference type="OMA" id="DHFDYPY"/>
    <dbReference type="PhylomeDB" id="Q9L200"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="217"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="511"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAB71810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="833" mass="92178" checksum="87911CF6DAA70F2C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2G1</accession>
    <name>Q9L2G1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2522</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626762.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028404.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2522"/>
    <dbReference type="GeneID" id="1097956"/>
    <dbReference type="KEGG" id="sco:SCO2522"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2567"/>
    <dbReference type="eggNOG" id="ENOG502ZB65">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876924_0_0_11"/>
    <dbReference type="OMA" id="GHLYMED"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="34759" checksum="3660748EE3D88E9B" modified="2000-10-01" version="1">MFRETAAEPRTQSVPLAHLSVELGHLYMEDFEAGPERLRAHFAEVRPWVEAARTAATARAGGKRPRISTCFLIDDYFTRFSTPAEVVPMLLAEAERAGLSVDYLARESGCAVTGKVPVAEAVAARIVESPPPGSYGLRPPAAQTGWLANGERSPVARTPQAMKRAAVWQPPHETAARRHSVFLDVELWSDDADGQRLWSCPFLAAVWQLARLGLLRNEGEAVLAPQPHTAGGFPDTWDELPTLLKLNERADPFAAYRTCSVLPTRFLPVEHAVRVILDQIEVDPGALAQVADRSGKERMAVPDSVADRISYVYYSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2H2</accession>
    <name>Q9L2H2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2511</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626751.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2511"/>
    <dbReference type="GeneID" id="1097945"/>
    <dbReference type="KEGG" id="sco:SCO2511"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2556"/>
    <dbReference type="eggNOG" id="ENOG502ZW3Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184570_2_0_11"/>
    <dbReference type="OMA" id="GAEWDCP"/>
    <dbReference type="PhylomeDB" id="Q9L2H2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7835" checksum="42F5A9203E0E36E0" modified="2000-10-01" version="1">MTTMPPVGVYAVDTRSGRVGIVMGHEGPYVQMRPYGGGREWDAEPGDVRHATASERLSAATAYTNARSRGEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCY9</accession>
    <name>Q9RCY9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0921</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625219.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977938.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0921"/>
    <dbReference type="GeneID" id="1096344"/>
    <dbReference type="KEGG" id="sco:SCO0921"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.915"/>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058962_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RCY9"/>
    <dbReference type="OMA" id="YLRLGAW"/>
    <dbReference type="PhylomeDB" id="Q9RCY9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="27962" checksum="1F72D04D7E6A2273" modified="2000-05-01" version="1">MTGVLTADRPPKPAAPRRYTVALARDEDDVRAAQRLRHDVFAGEMGALLASPQPGHDVDAFDAYCDHLLVREETTGQVVGTYRLLPPERAAVAGRLYAESEFDLAALDPIRSSLVEVGRSCVHPDHRDGAVIGLVWAGIARYMTDRGHAWLAGCCSLPLADGGALAAGAWDRVRTKHLAPEEYRVRPLLPWVPRPAAPAARTELPALLRGYLRLGAWVCGEPAHDVDFGVADLYVLLPMNRVDPRYLRHFLSLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCZ1</accession>
    <name>Q9RCZ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0919</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625217.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027446.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0919"/>
    <dbReference type="DNASU" id="1096342"/>
    <dbReference type="GeneID" id="1096342"/>
    <dbReference type="KEGG" id="sco:SCO0919"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.913"/>
    <dbReference type="eggNOG" id="COG3861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050193_1_0_11"/>
    <dbReference type="OMA" id="YGINWDS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2382" evidence="3">
        <location>
            <begin position="185"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB63168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="34895" checksum="7D0614EB84F00241" modified="2000-05-01" version="1">MITREEIANVLDQPVYDGDGNKIGDAKHVFFDDMTGRPEWVSVKTGMFGSTESFVPIRDAALVQDHLEVPYGKDQVKGAPSVDVDAGGHLSETEEHRLYDYYGINWDSVLSEAERTDDDRFAAGPGTAGAAGTAGAAGLAGTAGAAGAAGTAGGRTGREDAMRREGMRGDEGAMRREGMRGDEAMTRSEEQMHIGVERHESGRARLRKYVVTEEVQQTVPVTHEEVRVVREPITDANRDEALAGPEISEAEHEVTLHAERPVVETETVPVERVRMTTEELTENETVRGQVRKERIEAETESFTEGETKNARDDKRRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD26</accession>
    <name>Q9RD26_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0884</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625183.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027415.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0884"/>
    <dbReference type="GeneID" id="1096307"/>
    <dbReference type="KEGG" id="sco:SCO0884"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.875"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_3_11"/>
    <dbReference type="InParanoid" id="Q9RD26"/>
    <dbReference type="OMA" id="WGAHAAT"/>
    <dbReference type="PhylomeDB" id="Q9RD26"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="362"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="477" mass="50201" checksum="3833006D504D92BD" modified="2000-05-01" version="1">MTQSDSLTYDVVVIGAGPVGENVADRTRAAGLSTAIVESELVGGECSYWACMPSKALLRPVLARADARRLPGLAQSLQEPLDATAVLARRDEFTSHWKDDGQVQWVEGIGADLYRGQGRLAGPRTVEVAGPDGTRRTLSARHAVAVCTGSAAALPPLPGLAEVRPWTSREATSAERAPGRLIVVGAGVVAVEMATAWQALGSRVTMLVRGDGGLLARMEPFAGELVAEALTEAGVDIRTGVSVESVTRENGTVVAVTDTGDRLEADEILFATGRTPRTGDIGLDTVGLKPGSWLPVDDSLRVEGSDWLYAVGDVNHRALLTHQGKYQARIAGAAIAARASGVPILESDPWGAHAATADHDAVPQVVFTDPEVASVGLTLAEAEQAGHRVRAVDVPIAVAGSSLYGDGYKGRARMVVDLEDEIVRGVTFVGPGVGEMIHSATIAVAGRVPISRLWHAVPSYPTISEVWLRLLETYRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIV1</accession>
    <name>Q9RIV1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0955</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625252.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027467.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0955"/>
    <dbReference type="GeneID" id="1096378"/>
    <dbReference type="KEGG" id="sco:SCO0955"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.952"/>
    <dbReference type="eggNOG" id="ENOG502ZUS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200601_0_0_11"/>
    <dbReference type="OMA" id="PHILPGI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="58" mass="6418" checksum="5050C41A59C17F01" modified="2000-05-01" version="1">MTPETTTTPEQRTEERTGRAGRRPGELGSLDVWARSAPIRLAGYEEDLAEPHILPSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIW4</accession>
    <name>Q9RIW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0150</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624487.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026885.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0150"/>
    <dbReference type="GeneID" id="1095574"/>
    <dbReference type="KEGG" id="sco:SCO0150"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.126"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618052_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB58313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17013" checksum="19AB3B98FD584432" modified="2000-05-01" version="1">MGVAGYAERFPGGLRQALQRFSASAPGLAGVDRPEAVERRGGPIPVGGVLRRIGCADGILVGDAAGAVSPLTAGGLDPCLRLSEFAAEVLDHALRTRRPDALSAYDGAALRAAFRGRLTLRRALAQVRTPTVAQAAFTLLRTPIGRAAAGRVLFGDKSFPTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ45</accession>
    <name>Q9RJ45_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1823</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626091.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976999.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1823"/>
    <dbReference type="GeneID" id="1097257"/>
    <dbReference type="KEGG" id="sco:SCO1823"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1845"/>
    <dbReference type="eggNOG" id="COG3162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123372_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ45"/>
    <dbReference type="OMA" id="HRSFVFP"/>
    <dbReference type="PhylomeDB" id="Q9RJ45"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13871" checksum="A250973F880F3CFC" modified="2000-05-01" version="1">MATDAPPPSKEEPPSQEEHRLPSAEEFSEVQQSAEFAELRRSFRSFAFPLTVAFVAWYLLYVLLSNYAGGFMGTKLFGNINVAFVFGIAQFVTTFLIAWWYSRHAAAKLDPKAEAIKTRMEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJJ7</accession>
    <name>Q9RJJ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0391</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624713.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027080.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0391"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1095814"/>
    <dbReference type="KEGG" id="sco:SCO0391"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.367"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_35_0_11"/>
    <dbReference type="InParanoid" id="Q9RJJ7"/>
    <dbReference type="OMA" id="PAVRHGC"/>
    <dbReference type="PhylomeDB" id="Q9RJJ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="216"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB58332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="413" mass="44146" checksum="47D3EF37BB8151B4" modified="2000-05-01" version="1">MHVLVVHNRYNSAQPSGENNVVDQEVALLRAAGHRVGLFERRSDDIASRSLLGKVAVPLLVPWNPAVRRELADRLRTERPDVVHVHNVFPLLSPAVLAACADAGVPAVATLHNYTQVCPPGTLQRDGRPCTECVGAAPLPAVRHGCYRNSRLATVPLAVGLSVNRRRWWSGVERFFCISAAQREVLVGAGLPAERLAVKHNFVPDPEARRAGPGEHLLYLGRLAEAKGVRLLMEAWDELAADGGVGVPLVVAGTGPLEREVTAWAAGRDDVRYVGLYDPEQCRRALARSVAVVAPSTWLEAFGLVVVEAMAAGVPAVAAGHGAFAELVDDGVTGLLHRPGEAASLASRIRRIAAEPEGNQEMGRAARRRYEQGFSPAVGLERLLEGYRTAIAGRSALARDGDVRAGRGDGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJL9</accession>
    <name>Q9RJL9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0513</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624828.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978350.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0513"/>
    <dbReference type="GeneID" id="1095936"/>
    <dbReference type="KEGG" id="sco:SCO0513"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.493"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RJL9"/>
    <dbReference type="OMA" id="QEDPTDA"/>
    <dbReference type="PhylomeDB" id="Q9RJL9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB58273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="363" mass="38063" checksum="A2122F1362CB3218" modified="2000-05-01" version="1">MSAGLSAAKTRAALRTSARVSGELLLILVMLAVTLWVLGRMWSVVWPLLVGLLLTTLTWPPARFLRRHGWRPALAATVVTVAFLLVVLGIVALIAVPMSSQTDELTDGVVEGIQRLREWAAGPPLNIGDDEITGAMDSAVARIQDSVGSITTAVATGVGAVVNGLITAVLGVFLMFFFLKDGPRFLPWLARQLPGRLATDVPVVALRGWETLGSFVRSQALVGLLDAVFIGLGLWILGVPLVLPLAVLTFVSAFVPIVGALFAGFVAVLIALVSNGLTDALIVLAIIVVVQQLEGNVFQPILQSRGLGLHAAVILLAVTLGGSLSGIVGSLLAVPFAALIAVVWTYVREQLSERPEATATADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKD4</accession>
    <name>Q9RKD4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="9" type="ordered locus">SCO3153</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627369.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975663.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3153"/>
    <dbReference type="GeneID" id="1098587"/>
    <dbReference type="KEGG" id="sco:SCO3153"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3214"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKD4"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="PhylomeDB" id="Q9RKD4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB59649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="286" mass="30302" checksum="10C4F59DEEDB77DA" modified="2000-05-01" version="1">MTGTLVLAGTPIGDVQDAPPRLAAELAGADVVAAEDTRRLRRLTQALGVAPAGRVVSYFEGNESARTPELVEELAGGARVLLVTDAGMPSVSDPGYRLVAAAVERGVRVTAVPGPSAVLTALALSGLPVDRFCFEGFLPRKAGERLTRLREVAGERRTLVYFEAPHRLDDTLAAMAEVFGTDRRAAVCRELTKTYEEVRRGGLGELAAWAGEGVRGEITVVVEGAPDKGPEEVGAEELVRRVRVREEAGERRKEAIAAVAAEVGVPKREVFDAVVAAKNAEKNTGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-26" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKL1</accession>
    <name>PUR7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="1">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purC</name>
        <name type="ordered locus">SCO4071</name>
        <name type="ORF">SCD25.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628252.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974901.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKL1"/>
    <dbReference type="SMR" id="Q9RKL1"/>
    <dbReference type="STRING" id="100226.SCO4071"/>
    <dbReference type="GeneID" id="1099508"/>
    <dbReference type="KEGG" id="sco:SCO4071"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4130"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKL1"/>
    <dbReference type="OMA" id="TKFEFGF"/>
    <dbReference type="PhylomeDB" id="Q9RKL1"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100880" description="Phosphoribosylaminoimidazole-succinocarboxamide synthase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <sequence length="299" mass="33065" checksum="A1A5BF8A34B5AE25" modified="2000-05-01" version="1">MSGFVEKPEPIQVPGLVHLHTGKVRELYRNEAGDLVMVASDRISAYDWVLPTEIPDKGRVLTQLSLWWFDQLADLAPNHVLSTELPPGAPADWEGRALVCKSLRMVPVECVARGYLTGSGLAEYDETRTVCGLALPEGLVDGSELPAPIFTPATKAEVGEHDENVSYEEVARQVGADTAAALRQATLAVYSRARDIARERGIVLADTKFEFGFDGDDLVLADEVLTPDSSRFWPADRWQPGRAQPSYDKQFVRDWLTSAESGWDRKSEQPPPPLPQQVVDATRAKYVEAYELLTGQSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKN6</accession>
    <name>Q9RKN6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3 9 10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">SCO2292</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9 10">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3 9 10"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50601">
        <property type="entry name" value="T50601"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028255.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2292"/>
    <dbReference type="CAZy" id="CBM2">
        <property type="family name" value="Carbohydrate-Binding Module Family 2"/>
    </dbReference>
    <dbReference type="CAZy" id="GH11">
        <property type="family name" value="Glycoside Hydrolase Family 11"/>
    </dbReference>
    <dbReference type="GeneID" id="1097725"/>
    <dbReference type="KEGG" id="sco:SCO2292"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2329"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052631_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKN6"/>
    <dbReference type="OMA" id="WANGGRR"/>
    <dbReference type="PhylomeDB" id="Q9RKN6"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176940" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="44"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="13">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAB61738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="35533" checksum="EC8D55E788CCF0C2" modified="2000-05-01" version="1">MNLLVQPRRRRRGPVTLLVRSAWAVALAALAALMLPGTAQADTVVTTNQEGTNNGYYYSFWTDSQGTVSMNMGSGGQYSTSWRNTGNFVAGKGWANGGRRTVQYSGSFNPSGNAYLALYGWTSNPLVEYYIVDNWGTYRPTGEYKGTVTSDGGTYDIYKTTRVNKPSVEGTRTFDQYWSVRQAKRTGGTITTGNHFDAWARAGMPLGNFSYYMIMATEGYQSSGSSSINVGGTGGGDNGGGDNGGGGGGCTATVSAGQKWGDRYNLDVSVSGASDWTVTMNVPSPAKVLSTWNVNASYPSAQTLTARSNGSGNNWGATIQANGNWTWPSVSCSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKV4</accession>
    <name>Q9RKV4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630338.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030760.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6238"/>
    <dbReference type="GeneID" id="1101679"/>
    <dbReference type="KEGG" id="sco:SCO6238"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6352"/>
    <dbReference type="eggNOG" id="ENOG50314EV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094601_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKV4"/>
    <dbReference type="OMA" id="WTTIAAE"/>
    <dbReference type="PhylomeDB" id="Q9RKV4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="23924" checksum="148B67E17E75E4E6" modified="2000-05-01" version="1">MTDPELTAERGQGTGVWPLIRTERAALAADLAELTGEQWATPSLCAGLTVREVLAHLTAGASLNTVRWFAGVIRCRFDFDKQVAVRLAEQLGADPAETLARFRRVVPSTTKPPLPAIAMLGETLVHGEDIRRPLGIRHDYPVGVVTRVAEYYRGSDLVVVAKKRIEGLRLAADDGPFTTGSGPVVSGPTMALVMAMTGRETYCDDLEGDGVELLRDRCRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKY5</accession>
    <name>Q9RKY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1426</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625708.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977399.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1426"/>
    <dbReference type="GeneID" id="1096852"/>
    <dbReference type="KEGG" id="sco:SCO1426"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1436"/>
    <dbReference type="eggNOG" id="ENOG5033XHZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133302_0_0_11"/>
    <dbReference type="OMA" id="WNPFGLT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="16128" checksum="3FCDA26A50506ED0" modified="2000-05-01" version="1">MQSLKRPGRTTPKRQQPVVEPVSEGVEPDAFDDEELDAYDTFEMYRVLCPDCAQPIALLADEETLPEHALCASPWNPFGLTVCAGTGRRATEARPADESFRPHEQDTALLLTLPRGLDWRTQPFSHVGGPGSRPMRVPTMRREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL65</accession>
    <name>Q9RL65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2106</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626364.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028144.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2106"/>
    <dbReference type="GeneID" id="1097540"/>
    <dbReference type="KEGG" id="sco:SCO2106"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2140"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RL65"/>
    <dbReference type="OMA" id="AWTVCWL"/>
    <dbReference type="PhylomeDB" id="Q9RL65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="3">
        <location>
            <begin position="319"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="42212" checksum="BC2DBAD948CD39B7" modified="2000-05-01" version="1">MVVVGAGMAGVQTAVALREQGFTGPVTLIGAEPHQPYDRPPLSKAVLLGTAEGSAFDVDFEALGITLRLGCEALGVRPAEHVLDTSEGPVPYDVLVLATGAEPVRLPGAEGVPGVHLLRTLDDAERLRPVLARQHDVVVVGAGWIGAEFATAAREAGCAVTVVEAADRPLADALPAEVAAPMTAWYADAGAELRTRARVERVESGGPGESGRVVLDDGTRLAAGAVVVGIGARPATGWLAGSGIALGAHGEVLADDLLRTSAPDVHAVGDCASFPSARYGERLLVHHWDNALQGPRTVAADIVGTPGGETPAAYDPVPYFWSEQFGRFVQYAGHHTAADTTLWRGDPASPAWTVCWLREGRLVALLAVGRPRDLAQGRRLIQAGTPMDPDLLADPAKPLKAATAATA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S220</accession>
    <name>RECN_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">recN</name>
        <name type="ordered locus">SCO1780</name>
        <name type="ORF">SCI51.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36883">
        <property type="entry name" value="T36883"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626051.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027972.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S220"/>
    <dbReference type="SMR" id="Q9S220"/>
    <dbReference type="STRING" id="100226.SCO1780"/>
    <dbReference type="GeneID" id="1097211"/>
    <dbReference type="KEGG" id="sco:SCO1780"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1799"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S220"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="PhylomeDB" id="Q9S220"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000188026" description="DNA repair protein RecN">
        <location>
            <begin position="1"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="572" mass="59837" checksum="1D303A47D50BBC14" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S292</accession>
    <name>Q9S292_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1738</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36760">
        <property type="entry name" value="T36760"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027947.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S292"/>
    <dbReference type="STRING" id="100226.SCO1738"/>
    <dbReference type="GeneID" id="1097169"/>
    <dbReference type="KEGG" id="sco:SCO1738"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1756"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S292"/>
    <dbReference type="OMA" id="MTILCVR"/>
    <dbReference type="PhylomeDB" id="Q9S292"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB50953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="34594" checksum="1DAB2434D66DF03A" modified="2000-05-01" version="1">MTILCVRFQLPPTREAALPELLGLLEEFTPVVEALPPDGALADLRGAERYFGRDAVALASVIRVRALALHGVDCVIGAGPGPMLARMALRDARPGLTRAVPGGEERAFLDGKPVAALPGVGTATARTLCEYGLDTLGRVAAAPLSTLQRLVGARTGRELHEKAQGVDRGRVVPNGVSRSLAADRPFDRDELDPDRHRRALLSAAGDLGARLRAVDKVCRTLTLTVRYADRSATTRSRTLREPTAHSAALTRTAYDLYEALGLQRARVRSIALRAESLTSAEHASHQLTFDPVDEKVRRIEEVADRARAKFGPRAVMPGSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S298</accession>
    <name>Q9S298_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36754">
        <property type="entry name" value="T36754"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626005.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977094.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1732"/>
    <dbReference type="GeneID" id="1097163"/>
    <dbReference type="KEGG" id="sco:SCO1732"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1750"/>
    <dbReference type="eggNOG" id="ENOG5031W7M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211670_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="44" mass="5374" checksum="9499589B6800E8C4" modified="2000-05-01" version="1">MRRLTVQKPLKKTDARRVREEIDERPSGRPEVRKDIARTWWPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2F6</accession>
    <name>Q9S2F6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2925</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36148">
        <property type="entry name" value="T36148"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627151.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028665.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2925"/>
    <dbReference type="GeneID" id="1098358"/>
    <dbReference type="KEGG" id="sco:SCO2925"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2983"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_11"/>
    <dbReference type="InParanoid" id="Q9S2F6"/>
    <dbReference type="OMA" id="TRAYECD"/>
    <dbReference type="PhylomeDB" id="Q9S2F6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB51006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="488" mass="50656" checksum="26920283B1CBAF60" modified="2000-05-01" version="1">MIMSRIEAPRDEDDAAAAVDSTPGSTPGSPLGDRSTLVGRLLAGLPAGSVLTDPDVTASYANDMASFCPAGAPAAVVLPRTVEDVQHVMRTATALRVPVVPQGARTGLSGAANATDGCVVLSLTKMDRILEINPVDRVAVVEPGVVNATLSRAVNEHGLYYPPDPSSWEMCTIGGNIGTASGGLCCVKYGVTAEYVLGLDVVLADGRLMSTGRRTAKGVAGYDLTRLFVGSEGSLGIVVKAVLGLRPKPPEQLVLAAEFASASAACDAICRIMEGGHVPSLLELMDRTTVKAVNDLAHMGLPESTEALLLAAFDTTDPAADLAAVGALCEAAGATQVVPAEDAAESELLLQARRLALTALEAVKGTTMIDDVCVPRSRLGDMLEGIDRVAAKYGLTIGVCAHAGDGNTHPTVCFDVQDPDESRRARESFDEIMALGLELGGTITGEHGVGVLKKEWLAREIGPVGLEMQRAVKEVFDPLGILNPGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U0</accession>
    <name>Q9S2U0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2045</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35074">
        <property type="entry name" value="T35074"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028115.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2045"/>
    <dbReference type="GeneID" id="1097479"/>
    <dbReference type="KEGG" id="sco:SCO2045"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2076"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1287934_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2U0"/>
    <dbReference type="OMA" id="QLIRTGP"/>
    <dbReference type="PhylomeDB" id="Q9S2U0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="23613" checksum="17502BFC05713753" modified="2000-05-01" version="1">MSTFAKRERLLLADLLETAGPDAPTLCEGWRTRDLAAHVVVRERRPDAAGGALIKPLASRLHRVREEYGAKPYEELLQLIRTGPPRFSPFQLKQVDEAANTVEFYVHTEDVRRAQDDWSPRELDPVFQDALWSRLERVARLMGRGIPTGLVLRRPNGQTTVAHRGTPVVTATGEPSELLLFAYGRQGAAKVELEGEENAIAKLRETKQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7X1</accession>
    <name>Q9X7X1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6776</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35416">
        <property type="entry name" value="T35416"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630848.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031173.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6776"/>
    <dbReference type="GeneID" id="1102215"/>
    <dbReference type="KEGG" id="sco:SCO6776"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6885"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7X1"/>
    <dbReference type="OMA" id="LFDPVWG"/>
    <dbReference type="PhylomeDB" id="Q9X7X1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="88"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="370" mass="40334" checksum="4807F0A57EADB6D4" modified="1999-11-01" version="1">MARIRRSPHFRDGVFQNPGGTARTRPSGSAAEFAKIYFNKEARLRRSPQGPVPVHATTLADLARPPATGLRLTWMGHSSVLAEIDGQRVLFDPVWGERCSPFPFAGPKRLHQVPLPLAALGPVDVVVISHDHYDHLDMPTIKALAGTDTVFAVPLGVGGHLEHWGVSPDRLRELDWHESTRVGGLTLTATPARHFCGRGLRNTQHTLWASWVVAGAEHRVYHSGDTGYFDGFRDIGAAHGPFDATMIQLGAYAEFWPDIHMTPEEGVRAHLDLQGGGPHGALLPIHWGTFNLAPHAWAEPGEWTKDAAEEAGQPVAFPRPGEPFEPAGELPGEAWWRAVSQPIAHPWRRLETARSAAGKSRSELGLAGEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X812</accession>
    <name>COX4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber>7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ctaF</name>
        <name type="ordered locus">SCO2154</name>
        <name type="ORF">SC6G10.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35536">
        <property type="entry name" value="T35536"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626410.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976661.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X812"/>
    <dbReference type="SMR" id="Q9X812"/>
    <dbReference type="STRING" id="100226.SCO2154"/>
    <dbReference type="TCDB" id="3.D.4.4.5">
        <property type="family name" value="the proton-translocating cytochrome oxidase (cox) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1097588"/>
    <dbReference type="KEGG" id="sco:SCO2154"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2189"/>
    <dbReference type="eggNOG" id="ENOG5031SSV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145919_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X812"/>
    <dbReference type="OMA" id="GTYFRFV"/>
    <dbReference type="PhylomeDB" id="Q9X812"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220022" description="Probable cytochrome c oxidase polypeptide 4">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="132" mass="14581" checksum="12A6AFCFC3376438" modified="1999-11-01" version="1">MKIQGKMFIWLSVFILAVAVVYGYWSKEPAGTTALFLAFGLAIMIGFYLAFTARRVDAGAQDDMEADVADEAGEVGFFSPHSWQPLSLAVGGALAFLGIAVGWWVMYFSAPILMVGLFGWVFEYYRGENRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8A0</accession>
    <name>Q9X8A0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3524</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36165">
        <property type="entry name" value="T36165"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627724.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029060.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3524"/>
    <dbReference type="GeneID" id="1098960"/>
    <dbReference type="KEGG" id="sco:SCO3524"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3581"/>
    <dbReference type="eggNOG" id="ENOG50306DI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1250041_0_0_11"/>
    <dbReference type="OMA" id="HNIRLAH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="23607" checksum="285E5D0A5E45AA12" modified="1999-11-01" version="1">MPEYYSSIGEAVGAAMQHNIRLAHRSAAPGSDKPLQVRHLPSASADPYSVRGMISRLHEDASPDEVAGIIEEVNGALVGALPELTELVASAADWTRARLDFDDPHHHPTFETWTRLAAAYGMLQDVREQLEVAEDGLAACPAERTDPRHHQMVNVLRSRELLDDVLGAEAAPVPFAARNVDSDRQRAARASSPRAGTSPSTGGPPATAAPPPAPRSAGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8L0</accession>
    <name>Q9X8L0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36357">
        <property type="entry name" value="T36357"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028972.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3431"/>
    <dbReference type="GeneID" id="1098868"/>
    <dbReference type="KEGG" id="sco:SCO3431"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3493"/>
    <dbReference type="eggNOG" id="ENOG5031M3X">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099460_0_0_11"/>
    <dbReference type="OMA" id="ELEGSWL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="23481" checksum="CADDBDE140F940EA" modified="1999-11-01" version="1">MRLFGAERPSGYSLELPVTWVTAGNTASTENTASAESTSGAWRTGVAAGTASATAPGTDVRSGGVAFRRSRRTRRSVRVAALSLGLVGALALTACTDGGDSDGGGSGEGSGGDKSSAAPGASASTDPGGDAGGSPSAGAAGELEGSWLATTDGQAVALMVTGDKAALFATGGTVCSGTTEETSGTRTIRLKCADGSADRATGKVGAVGATSLTVAWEGALGKETYTRSEGGSLPPGLPTAGIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8R0</accession>
    <name>Q9X8R0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3643</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB42030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3643"/>
    <dbReference type="ESTHER" id="strco-q9x8r0">
        <property type="family name" value="Duf_1023"/>
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    <dbReference type="GeneID" id="1099079"/>
    <dbReference type="KEGG" id="sco:SCO3643"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3703"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025057_0_1_11"/>
    <dbReference type="InParanoid" id="Q9X8R0"/>
    <dbReference type="OMA" id="GGHSDYF"/>
    <dbReference type="PhylomeDB" id="Q9X8R0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177023" evidence="1">
        <location>
            <begin position="37"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="33885" checksum="46504E104E0483AC" modified="1999-11-01" version="1">MGPGTTVRWRRRVSGWRRAGCAALIAGAVALPLSGAARPEIPAPPPAALAAPTAATLDKAYAANRANAAEASRMAADHGDRHRAAADRAMADRSRRLLAFDGRGTGLATEVFGDLARADRVAVLVPGSDTGLDTYGRFRATALALHRQLVAEAPAGTRTAVVAWLGYETPGTVSTTVATTDRADRAAPELRALVGDLRRITGPGTRLALLCHSYGSVVCARAADGLEVADIALVGSPGTGADTAAGLHSEARVWAGRGAEDWVEHVPHVSADLFGTTVGFGTDPVSPAFGARVFDAGDGGHSDYFDPGSRSLTNLARIALGETTEVTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8T0</accession>
    <name>Q9X8T0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3894</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36581">
        <property type="entry name" value="T36581"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628080.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029297.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3894"/>
    <dbReference type="GeneID" id="1099330"/>
    <dbReference type="KEGG" id="sco:SCO3894"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3967"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_3_0_11"/>
    <dbReference type="InParanoid" id="Q9X8T0"/>
    <dbReference type="OMA" id="KIFWPSA"/>
    <dbReference type="PhylomeDB" id="Q9X8T0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="811" mass="85051" checksum="9DB634F3BFBF2C41" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X912</accession>
    <name>Q9X912_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3546</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36667">
        <property type="entry name" value="T36667"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627744.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975389.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3546"/>
    <dbReference type="GeneID" id="1098982"/>
    <dbReference type="KEGG" id="sco:SCO3546"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3602"/>
    <dbReference type="eggNOG" id="ENOG502ZCPR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096767_0_0_11"/>
    <dbReference type="OMA" id="GTNPVNK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177029" evidence="2">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="20367" checksum="065500CA877063E9" modified="1999-11-01" version="1">MEGTNPVNKKLAAALSGGAVLVLALTGCSSSDDNEKLDSWAKDVCEGVQPQAKKIEAANAAIQKETSDNSTPAEVQKTDAKAFQDMSDAYKAMGATVQKAGPPDVDDGEKKQKDAVTELNGLSASYASLRKQVEELDTKDQAKFADGLKDIATELNKLSKSGSNALKTLEEGDVGQAMAKQPSCKSASVTPSAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA04</accession>
    <name>Q9XA04_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3860</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36729">
        <property type="entry name" value="T36729"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628048.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029276.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3860"/>
    <dbReference type="GeneID" id="1099296"/>
    <dbReference type="KEGG" id="sco:SCO3860"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3931"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="InParanoid" id="Q9XA04"/>
    <dbReference type="OMA" id="LAPEQMM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB45227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="576" mass="59817" checksum="3A8DE0A5E70B8C69" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA78</accession>
    <name>Q9XA78_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0847</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36460">
        <property type="entry name" value="T36460"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625147.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978012.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0847"/>
    <dbReference type="GeneID" id="1096270"/>
    <dbReference type="KEGG" id="sco:SCO0847"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.839"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134376_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA78"/>
    <dbReference type="OMA" id="CIIKVAN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB48924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="16475" checksum="BB8E60044C58FE2B" modified="1999-11-01" version="1">MGMRREDLPAPESGLLLTHFLTVADVPRSRAFYSEVLGGEVVLAENPCIVKLANSWIIMNPGGGPTPDKPDVTLRPPDDPGTATSFLNIRVADIERCHREWSALGAEFLTPPIDRKAELRCYLRDPDGYLIEVGQATGLLEGILADPPAGRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ6</accession>
    <name>NUOC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoC</name>
        <name type="ordered locus">SCO4564</name>
        <name type="ORF">SCD16A.19c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34622">
        <property type="entry name" value="T34622"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628726.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029733.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAQ6"/>
    <dbReference type="SMR" id="Q9XAQ6"/>
    <dbReference type="STRING" id="100226.SCO4564"/>
    <dbReference type="GeneID" id="1100004"/>
    <dbReference type="KEGG" id="sco:SCO4564"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4636"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAQ6"/>
    <dbReference type="OMA" id="RFELCTG"/>
    <dbReference type="PhylomeDB" id="Q9XAQ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000358202" description="NADH-quinone oxidoreductase subunit C">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="251" mass="27967" checksum="8979638C19AEDB85" modified="1999-11-01" version="1">MSDANNTAGDANEVNPEKDLSAENLPGQRGQGGEEIRVQRGMFGANNGGDTSGYGGLVRSVRLPGPASRPYGGWFDEVADELEGALEEQGLLPDNAIEKTVVDRGELTFHIEREHLVRVARTLRDDPALRFELCTGVSGVHYPHDKGRELHAVYHLRSITHNRLIRLEVSAPDGDPHIPSLVSVYPTNDWHERETYDFFGIVFDDHPALTRIMMPDDWQGFPQRKDYPLGGIPVEYKGAQIPAPDQRRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z599</accession>
    <name>Q9Z599_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6203</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34857">
        <property type="entry name" value="T34857"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630306.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030739.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6203"/>
    <dbReference type="GeneID" id="1101644"/>
    <dbReference type="KEGG" id="sco:SCO6203"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6316"/>
    <dbReference type="eggNOG" id="ENOG5032256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171136_1_0_11"/>
    <dbReference type="OMA" id="IEWQGGG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="112" mass="12019" checksum="EF2A288273A49EA0" modified="1999-05-01" version="1">MRTVPHPALPGVLPGADSPPAQQPGGMATAHPPEHPHIVVHSPALDGSRRVTSGEETLGIASHVDDVAELLRLADLYVTDVESSDLVEWQGGGPEDWPGLHEHHEHHEHRGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBH5</accession>
    <name>DCDA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name type="ordered locus">SCO6438</name>
        <name type="ORF">SC9B5.05</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35925">
        <property type="entry name" value="T35925"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630523.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030919.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBH5"/>
    <dbReference type="SMR" id="Q9ZBH5"/>
    <dbReference type="STRING" id="100226.SCO6438"/>
    <dbReference type="GeneID" id="1101877"/>
    <dbReference type="KEGG" id="sco:SCO6438"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6538"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBH5"/>
    <dbReference type="PhylomeDB" id="Q9ZBH5"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000149935" description="Diaminopimelate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="440" mass="47549" checksum="8DC03E8650DB3921" modified="1999-05-01" version="1">MTSPSAPSSAERPRLPGALDGPRLAAAAAEHGTPLWLYDAATIRAQIDRLRRFDVIRYAQKACSNLHILRLMREEGVHVDAVSEGEIERALAAGYRVGGDDEPIVFTADLLNRSTLRRVVELGIPVNAGSPQMLDQVGRAAPGHPVWIRINPGFGHGHSRKTNTGGEHSKHGIWHEHLEESLALVDRHGLDLVGLHMHIGSGVDYGHLESVCETMVKQVRMAGRDIRAISAGGGLSVPYTPGDPEIDTDRYFELWDAARRELVSELGHPVRLEIEPGRFLVAGAGVLAAEVRAQKPVGSNYFVLVDAGFNDLMRPAMYGSNHRVSVLDADGAPRASDARDTVLAGPLCESGDVFTQVEGGDVEPVPVPRTDVGDLVVFHDTGAYGASMSSTYNSRPLIPEVLVDGAETRLIRRRQTVAELLAPELEPGPALSPRPSRDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBI9</accession>
    <name>Q9ZBI9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6485</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35972">
        <property type="entry name" value="T35972"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630568.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030956.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6485"/>
    <dbReference type="GeneID" id="1101924"/>
    <dbReference type="KEGG" id="sco:SCO6485"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6586"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099335_0_0_11"/>
    <dbReference type="OMA" id="AWESYWR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="25238" checksum="8F2883CFA95C2136" modified="1999-05-01" version="1">MSVTSRYRDAWEGFWNEASGDRGAVFWDAEPTLTAGRHLAHFEPHLTDAALPLIDLGCGNGTQTRYFAERFPHVVGADLSAAALAHARHADPGGLAAYRQLDAADKAEAQALHAELGDANVYVRGVLHQCEPDDRQPLADALAALLGERGRAFLVEPSQAAKTVLMGLAQGPAGPPAKLAPVLRHGLTPGAVPDEAVPEYLRAAGLTVLASGELPLVTTEYTADGTRIELPSAWVVAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBS4</accession>
    <name>Q9ZBS4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DksA C4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6164</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34677">
        <property type="entry name" value="T34677"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630269.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972760.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6164"/>
    <dbReference type="GeneID" id="1101605"/>
    <dbReference type="KEGG" id="sco:SCO6164"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6273"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_4_11"/>
    <dbReference type="InParanoid" id="Q9ZBS4"/>
    <dbReference type="OMA" id="CAKPIPA"/>
    <dbReference type="PhylomeDB" id="Q9ZBS4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA22398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="108" mass="12010" checksum="420D3D71B6DCB3D6" modified="1999-05-01" version="1">MSLDASRIEPRPERLTAHEARQRLEHARNTRVTQLQALAESGQADDQLMSAQKAAIERVLKEIDEAFARVEEGTYGACLGCGKPVPGERLEILPYTRYCVACQRRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBS7</accession>
    <name>Q9ZBS7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6161</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34674">
        <property type="entry name" value="T34674"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630266.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030699.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6161"/>
    <dbReference type="GeneID" id="1101602"/>
    <dbReference type="KEGG" id="sco:SCO6161"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6269"/>
    <dbReference type="eggNOG" id="ENOG5031TQ2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1824257_0_0_11"/>
    <dbReference type="OMA" id="CGHARTS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177080" evidence="2">
        <location>
            <begin position="28"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="129" mass="12744" checksum="95EEC97C1AF62C6F" modified="1999-05-01" version="1">MRRRLASVLTVLLTVLLPLVPAWPAAGAHVGPSGPLAAAAATAVPHPALDLHADDGCTPVCAAQPRARHDQPAGRPTAPDQHPATTAHLGGGAAPCGHARTSFAPGPVPVSPGRASHDSGRAPPVSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBX5</accession>
    <name>Q9ZBX5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36063">
        <property type="entry name" value="T36063"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628141.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029341.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3957"/>
    <dbReference type="TCDB" id="3.A.1.146.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099393"/>
    <dbReference type="KEGG" id="sco:SCO3957"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4029"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933101_0_0_11"/>
    <dbReference type="OMA" id="IHNIGYR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="293" mass="30731" checksum="7B1A4D7CAE773EEA" modified="1999-05-01" version="1">MPGDQTRIHNIGYRSYDGPRLGRAYARRSLYSQSLRGSYGLGRSAKSKVLPMLLFVVMCLPAGIMVAVAVATKANDLPVDYTRYAIVLQAVISLYVAAQAPQSVSRDLRFKTVPLYFSRPIETSDYVRAKYASLASALFILTAAPLLVLYVGALLAKLDFADQTKGFAQGLVSVALLSLLFAGLGLVVASVTPRRGFGIAAVIAVLTITYGAVSTLQAIADVQGSSGAVAWIGLFSPITLIDGVQSAFLGATSASPGGVGPSNGEGAVYVLVTLGLIAGAYGLLMRRYKKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O69834</accession>
    <name>O69834_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6046</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA18980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34684">
        <property type="entry name" value="T34684"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630156.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030616.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6046"/>
    <dbReference type="GeneID" id="1101487"/>
    <dbReference type="KEGG" id="sco:SCO6046"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6147"/>
    <dbReference type="eggNOG" id="COG1990">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090594_0_0_11"/>
    <dbReference type="OMA" id="MAQAGHG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="26824" checksum="211A10745585A11D" modified="1998-08-01" version="1">MSNDPTTPVPAPVPAPDSPFRPEPGDRDLAPQFVLPLVVRIERAAPPSRTDALETAARAVLVMLGDERSTGDGAWARAVRDWQDARIRKVVRRARGAEWRRAEALPGITVTGKNAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPEPPVDADPTAPVLWLNPDLDMSAGKAMAQAGHGAQLAWWELSDAERTAWRDAGFPLSVRTADPARWTGLTTGGLPVVRDAGFTEIAPGSCTVVADHPALRRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O69902</accession>
    <name>O69902_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5614</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34799">
        <property type="entry name" value="T34799"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629748.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030340.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5614"/>
    <dbReference type="GeneID" id="1101055"/>
    <dbReference type="KEGG" id="sco:SCO5614"/>
    <dbReference type="HOGENOM" id="CLU_066192_29_2_11"/>
    <dbReference type="InParanoid" id="O69902"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="6994" checksum="64D4FABC6A7EA2AB" modified="1998-08-01" version="1">MFSGRKLKEARNKRGMSQAAVAARMGLSGLYVSYWENGRYAPNGVNMVLLLRALGCELEEVTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O86560</accession>
    <name>PGLW_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable kinase PglW</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bacteriophage (PhiC31) resistance gene PglW</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pglW</name>
        <name type="synonym">SC1F2.23</name>
        <name type="ordered locus">SCO6626</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="Mol. Microbiol." volume="7" first="329" last="336">
            <title>Genetic analysis of the phi C31-specific phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Laity C."/>
                <person name="Chater K.F."/>
                <person name="Lewis C.G."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="8446035"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1993.tb01124.x"/>
        </citation>
        <scope>GENETIC ANALYSIS</scope>
        <scope>PHASE REVERSION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="44" first="489" last="500">
            <title>Genetics of the phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Sumby P."/>
                <person name="Smith M.C."/>
            </authorList>
            <dbReference type="PubMed" id="11972785"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2002.02896.x"/>
        </citation>
        <scope>FUNCTION IN ANTIVIRAL DEFENSE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2015" name="EMBO J." volume="34" first="169" last="183">
            <title>BREX is a novel phage resistance system widespread in microbial genomes.</title>
            <authorList>
                <person name="Goldfarb T."/>
                <person name="Sberro H."/>
                <person name="Weinstock E."/>
                <person name="Cohen O."/>
                <person name="Doron S."/>
                <person name="Charpak-Amikam Y."/>
                <person name="Afik S."/>
                <person name="Ofir G."/>
                <person name="Sorek R."/>
            </authorList>
            <dbReference type="PubMed" id="25452498"/>
            <dbReference type="DOI" id="10.15252/embj.201489455"/>
        </citation>
        <scope>CLASSIFICATION AND NOMENCLATURE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="Virology" volume="477" first="100" last="109">
            <title>The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.</title>
            <authorList>
                <person name="Hoskisson P.A."/>
                <person name="Sumby P."/>
                <person name="Smith M.C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25592393"/>
            <dbReference type="DOI" id="10.1016/j.virol.2014.12.036"/>
        </citation>
        <scope>FUNCTION AS A KINASE</scope>
        <scope>MUTAGENESIS OF LYS-677</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6 9 10">BREX systems (bacteriophage exclusion) provide immunity against bacteriophage. Part of a type 2 BREX system (Probable). Previously called the phage growth limitation (Pgl) system, it confers protection against bacteriophage phiC31. The bacteria allows one cycle of phage infection, but subsequent cycles are impaired, protecting the original bacterial colony (Probable). The system undergoes high rates (10(-3) to 10(-4)) of phase reversion, i.e. loss and regain of phiC31 resistance (PubMed:8446035). When the pglW-pglX-pglY-pglZ genes are transformed into a susceptible S.lividans (strain 1326) they confer resistance to infection by phage phiC31 and phiBT1; all 4 genes are necessary (PubMed:11972785). The proteins has kinase domains and might bind DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Autophosphorylates when synthesized in vitro, cannot be expressed in E.coli.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Constitutively expressed, probably part of a pglW-pglX operon.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The first protein kinase domain is predicted to be catalytically inactive.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Strain is no longer resistant to plaque formation by bacteriophage phiC31 (a Pgl- phenotype).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29132">
        <property type="entry name" value="T29132"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630703.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031052.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86560"/>
    <dbReference type="SMR" id="O86560"/>
    <dbReference type="STRING" id="100226.SCO6626"/>
    <dbReference type="GeneID" id="1102065"/>
    <dbReference type="KEGG" id="sco:SCO6626"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6734"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005315_0_0_11"/>
    <dbReference type="OMA" id="DDHAERY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000452169" description="Probable kinase PglW">
        <location>
            <begin position="1"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="NERD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase 1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase 2" evidence="1">
        <location>
            <begin position="530"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="821"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="536"/>
            <end position="544"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Does not complement the Pgl- phenotype of a deletion mutation, does not autophosphorylate." evidence="5">
        <original>K</original>
        <variation>A</variation>
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="25592393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="8446035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="25452498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1557" mass="169204" checksum="D53E18C3BE28392E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O86791</accession>
    <name>O86791_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TsaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35579">
        <property type="entry name" value="T35579"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628908.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029839.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4750"/>
    <dbReference type="GeneID" id="1100191"/>
    <dbReference type="KEGG" id="sco:SCO4750"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4822"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_3_3_11"/>
    <dbReference type="InParanoid" id="O86791"/>
    <dbReference type="OMA" id="DEVYWGC"/>
    <dbReference type="PhylomeDB" id="O86791"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="22621" checksum="CBD21830F7E07C78" modified="1998-11-01" version="1">MLLLALDTATPAVTVALHDGTDVIASSSQVDARRHGELLLPAVDRVLAEAGLRLDAVTAVVAGIGPGPYTGLRVGLMTADAFGLALGVPVHGVCTLDGLAFAADLEGPFVVATDARRKEVYWARYADSRTRLTDPAVDRPADIAGQVAGLPAVGAGALLYPDTFPRAHEPEHVSAAALARLAAEKLAAGEELPAPRPLYLRRPDAQVPKNYKVVTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O88048</accession>
    <name>O88048_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36823">
        <property type="entry name" value="T36823"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625864.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027867.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1588"/>
    <dbReference type="GeneID" id="1097019"/>
    <dbReference type="KEGG" id="sco:SCO1588"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1600"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056500_0_0_11"/>
    <dbReference type="InParanoid" id="O88048"/>
    <dbReference type="OMA" id="CIAVTQR"/>
    <dbReference type="PhylomeDB" id="O88048"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="184"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="32669" checksum="D522DBEADA5EC2EC" modified="1998-11-01" version="1">MRAQSSATASPRIAVDATGADAGGASFGTVQAALGVVAFSLTFPATAWGLEGFGPWSLIAVRSVLAAAVAGSCLVVVGVPPRERSRAWGRVAPPERRHWLGLAVVGAGVVLGFPLLTTLALQTSTTAHAAVVVGLLPLTTALLSALRVGTRPSRTFWIAALAGAAAVIAFTVQQSGGALTSADAYLFAALLVCAAGYTEGGRLARVMPGWQVIGWALVLCLPLTVPMAAIALSLEPVRLTAHAVTGLLWVAIGSQFLGLVVWYRGMAAIGIPKASQLQLAQPLLTLVWSVLLLGEHLPVAAPLTAAAVLVCIAVTQRARG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>P0A477</accession>
    <accession>O69883</accession>
    <name>RL19_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplS</name>
        <name type="ordered locus">SCO5595</name>
        <name type="ORF">SC2E1.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34780">
        <property type="entry name" value="T34780"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629729.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973398.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A477"/>
    <dbReference type="SMR" id="P0A477"/>
    <dbReference type="STRING" id="100226.SCO5595"/>
    <dbReference type="GeneID" id="1101036"/>
    <dbReference type="KEGG" id="sco:SCO5595"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5687"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_11"/>
    <dbReference type="InParanoid" id="P0A477"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="PhylomeDB" id="P0A477"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000163539" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="116" mass="13142" checksum="37D782C6763D0A90" modified="2005-03-15" version="1">MSHLLDSVDAASLRSDVPAFRPGDTVNVHVRVIEGNRSRVQQFKGVVIRRQGAGVRETFTVRKVSFSVGVERTFPVHTPIVEKIELVTRGDVRRAKLYYLRELRGKAAKIKEKRDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>P0A4I7</accession>
    <accession>Q03757</accession>
    <name>CUTS_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Sensor protein CutS</fullName>
            <ecNumber>2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cutS</name>
        <name type="ordered locus">SCO5863</name>
        <name type="ORF">SC2E9.04</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34815">
        <property type="entry name" value="T34815"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629985.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973157.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A4I7"/>
    <dbReference type="SMR" id="P0A4I7"/>
    <dbReference type="STRING" id="100226.SCO5863"/>
    <dbReference type="GeneID" id="1101305"/>
    <dbReference type="KEGG" id="sco:SCO5863"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5962"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_11"/>
    <dbReference type="InParanoid" id="P0A4I7"/>
    <dbReference type="OMA" id="FPWLRPT"/>
    <dbReference type="PhylomeDB" id="P0A4I7"/>
    <dbReference type="BRENDA" id="2.7.13.3">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <feature type="chain" id="PRO_0000074744" description="Sensor protein CutS">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="202"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="414" mass="44496" checksum="B1CBC2DFBD0ABB4D" modified="2005-03-15" version="1">MATTPAPPGAPPKPTWDPRSATPLPWLRPTIRIRLTLLYGGMFLIAGILLLSIIYLLAAQAVRTGNEPLYKIVDFTDLKVSSSTCPVVDNGGLSLSDFNAAISDCMDHQRKVALDNLLSRSLLALLGLAVIAFAFGYAMAGRVLSPLGRITRTARAVAGSDLSRRIELDGPDDELKELADTFDDMLERLQRAFTAQQRFVGNASHELRTPLAINRTLLEVHLSDPGAPVELQQLGKTLLATNERSELLVEGLLLLARSDNQIVERKPVDLAEVAGQAIDQVHAEAESKGVEVRGTREAAVVQGNGVLLERIALNLVQNAVRYNVAGQGWVEVATAVENGQAVLVVTNTGPVVPAYEVDNLFEPFRRLRTERTGSDKGVGLGLSIARSVARAHGGHISAQPREGGGLVMRVTLPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>P48950</accession>
    <accession>Q9L0L2</accession>
    <name>RL1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">SCO4649</name>
        <name type="ORF">SCD82.20</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Mol. Gen. Genet." volume="247" first="118" last="122">
            <title>Cloning, nucleotide sequence, and transcriptional analysis of the nusG gene of Streptomyces coelicolor A3(2), which encodes a putative transcriptional antiterminator.</title>
            <authorList>
                <person name="Puttikhunt C."/>
                <person name="Nihira T."/>
                <person name="Yamada Y."/>
            </authorList>
            <dbReference type="PubMed" id="7715599"/>
            <dbReference type="DOI" id="10.1007/BF00425829"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-73</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="D32254">
        <property type="protein sequence ID" value="BAA22059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S54719">
        <property type="entry name" value="S54719"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628810.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974314.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P48950"/>
    <dbReference type="SMR" id="P48950"/>
    <dbReference type="STRING" id="100226.SCO4649"/>
    <dbReference type="GeneID" id="1100090"/>
    <dbReference type="KEGG" id="sco:SCO4649"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4720"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_11"/>
    <dbReference type="InParanoid" id="P48950"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="PhylomeDB" id="P48950"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125745" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="241" mass="25764" checksum="8DC2A82C5C7D286B" modified="2001-10-18" version="2">MSKRSKSLRAADAKIDRDKLYAPLEAVRLAKETSTSKFDGTVEVAFRLGVDPRKADQMVRGTVNLPHGTGKTARVLVFATGDRAEAATAAGADIVGSDELIDEVSKGRLDFDAVVATPDLMGKVGRLGRVLGPRGLMPNPKTGTVTPDVAKAVNDIKGGKIEFRVDKHSNLHFIIGKTSFDDTKLVENYGAALEEILRLKPSAAKGRYIKKAALSTTMGPGIPLDSNRTRNLLVEEDPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK65</accession>
    <name>Q8CK65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0255</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAD55431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36395">
        <property type="entry name" value="T36395"/>
    </dbReference>
    <dbReference type="PIR" id="T37170">
        <property type="entry name" value="T37170"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733494.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026964.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0255"/>
    <dbReference type="GeneID" id="1095679"/>
    <dbReference type="KEGG" id="sco:SCO0255"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.227"/>
    <dbReference type="eggNOG" id="COG3284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_12_11"/>
    <dbReference type="InParanoid" id="Q8CK65"/>
    <dbReference type="OMA" id="HVEVTFE"/>
    <dbReference type="PhylomeDB" id="Q8CK65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
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    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="310"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="578" mass="61641" checksum="2DAC118D0479138D" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J16</accession>
    <name>Q93J16_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3992</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628174.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029363.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3992"/>
    <dbReference type="GeneID" id="1099428"/>
    <dbReference type="KEGG" id="sco:SCO3992"/>
    <dbReference type="HOGENOM" id="CLU_2358394_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="96" mass="10939" checksum="34979837D544F7FE" modified="2001-12-01" version="1">MESIARRPCAHRPKVCYLFRQLRCCFRKWTFRSYERVESLEGGCCKPWKKQEQVSLGSARALQLAEIVSPLRLAQPTAYPVGKGVSRVGDKAARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J78</accession>
    <name>Q93J78_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2819</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627048.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028603.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2819"/>
    <dbReference type="GeneID" id="1098253"/>
    <dbReference type="KEGG" id="sco:SCO2819"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2877"/>
    <dbReference type="eggNOG" id="ENOG5033WXT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109395_0_0_11"/>
    <dbReference type="OMA" id="FGRRMLD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="21681" checksum="DC2C849468F88AA4" modified="2001-12-01" version="1">MSSTRNATPHASDVTSDGAAWLASAGAYPRSTLALWEERPEAPVVLPCGSTFDVVSAPAIFGRRMLDRLWDDGPGSGPVAEFRGRMLLFAAPGTAQRLPSLLDWEEWSTRGREGGRAGAVPPLLCHGAGDAVTVPAPAGPAAPADAPPRSGSRWLVAPDTRRPWLPGPEIMLWAAVRAARAAVRISIFPPADQDAKVYDVSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JD7</accession>
    <name>Q93JD7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630106.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030583.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5990"/>
    <dbReference type="GeneID" id="1101432"/>
    <dbReference type="KEGG" id="sco:SCO5990"/>
    <dbReference type="eggNOG" id="ENOG5031T16">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195364_0_0_11"/>
    <dbReference type="OMA" id="RWVEVEI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8722" checksum="D460F1C5DF52A740" modified="2001-12-01" version="1">MTEERGEFTALGPYTYRPGRSHCPSPSDGTLTRGGHPVPLRVTEPVLQRFLDVMTELETGLAERWGRTQGSLTYTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RU4</accession>
    <name>Q93RU4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1882</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626149.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976938.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1882"/>
    <dbReference type="GeneID" id="1097316"/>
    <dbReference type="KEGG" id="sco:SCO1882"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1907"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="InParanoid" id="Q93RU4"/>
    <dbReference type="OMA" id="KMVAQWD"/>
    <dbReference type="PhylomeDB" id="Q93RU4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176593" evidence="1">
        <location>
            <begin position="33"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC38817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="452" mass="47860" checksum="B2F34DFF0DD9BE2E" modified="2001-12-01" version="1">MLSSRDKGTVRRRTSAAVALGAVLALTATACGDDGSGAGGDKGAEGSGKGKITFWDNNGGIRTAVWKTIIADFEKANPDIDVEYVGIAATEYQSKVDTAIQGGGLPDVGGVTASMLAGFSAQGALEPLDDRLGKSPLSDKVNKDMVESLKAAGGGDGTLYSMPTSANNGVLYYRTDLFEKAGLDAPTTWDKFYAAAEKLTDAGKNEFGYTIRGGSGSIAQALDAMYGQSGITSFWDAGKKKTTVNDPKNVEALEKYAALYKKVTPAADVNNDFAKMVAQWDTGTIGMLNHNLGSYQDHVKALGVDKFRGIPQPVGASGKRVQVSNPVDGLGMFKSSKNKEAAWKFIEFATSKEQNSKFNESAGQVPSSTEAANDAWIQKAEPTKLAAQALNDGSTTIVQLPYYLPDWNTLSKSESEPGFQKVLLGDMSAKDFLDGLADKLNEAQAEWTEQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RX1</accession>
    <name>Q93RX1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1855</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626122.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1855"/>
    <dbReference type="GeneID" id="1097289"/>
    <dbReference type="KEGG" id="sco:SCO1855"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1879"/>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_11"/>
    <dbReference type="InParanoid" id="Q93RX1"/>
    <dbReference type="OMA" id="TRSHLYH"/>
    <dbReference type="PhylomeDB" id="Q93RX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC38790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="30467" checksum="D3ACF4B4DFD96670" modified="2001-12-01" version="1">MRRMHRRGPKTMDSEAKVTFVGAGPGAADLLTFRAARAIAEADVVIWAASLVQAEVLQHAREGAEVLDSATMSLEDVVAVYRRARAEGLRVARIHSGDPALWGGTQEQLDRCAEIGVATEVVPGVSAFSAVAALAQRELTIPEVAQSVVLTRLGGGKTPMPPGEEVREFAKHGTTMAVFLSAARSGQLVRELLEGGYPTETPVIVAYQATWPEELVVRCTIGTLEETVKEHRLWKHTLFLVGPALDAHGTRSHLYHPGHFHGYRKADPEARRELRSRGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD43</accession>
    <name>Q9AD43_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.107</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639680.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039406.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095185"/>
    <dbReference type="KEGG" id="sco:SCP1.107"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8055"/>
    <dbReference type="HOGENOM" id="CLU_1969234_0_0_11"/>
    <dbReference type="OMA" id="VDHGHEM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13827" checksum="78532DC1D21C4AE7" modified="2001-06-01" version="1">MPHTRRSLIDAAVARLGWRRAHTTTAEVDAVLAEQTATARRQANDTARLTLRPHDSALVMQPGILDIRARVLADVGHLETALDGARRHGMPDNLIRRLEAAVDHGHEMTVLLADTVRATADAHTAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADC0</accession>
    <name>Q9ADC0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5348</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629488.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030197.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5348"/>
    <dbReference type="GeneID" id="1100788"/>
    <dbReference type="KEGG" id="sco:SCO5348"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_13_0_11"/>
    <dbReference type="OMA" id="RTVDEKM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="61" mass="7164" checksum="5BE5C25378574C30" modified="2001-06-01" version="1">MKDELMTVPQILDELGGVSRRTFYRWRELGQGPAAFKLPNGELRVWRSDFRTWLRQLEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJZ9</accession>
    <name>Q9AJZ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7729</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631767.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031864.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7729"/>
    <dbReference type="GeneID" id="1103167"/>
    <dbReference type="KEGG" id="sco:SCO7729"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7851"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_1_0_11"/>
    <dbReference type="InParanoid" id="Q9AJZ9"/>
    <dbReference type="OMA" id="TARDFQH"/>
    <dbReference type="PhylomeDB" id="Q9AJZ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="46"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC22737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="35974" checksum="7E05869A9386B0ED" modified="2001-06-01" version="1">MNSPEGDVDALRRGVDPLAEGDRPAGSPRVGVLSAREVPLGGPRAMRVRRTLPQRARTLIGAWCFADHYGPLEVATSGGMVMSPHPHTGLQTVSWLFGGEIEHRDTLGTHALIRPGEMNLMTGGHGIAHSEVSTPRTTVLHGVQLWVALPEEHRHTARDFQHHVPAAVQVDGAEVRVFLGSLAGLTSPVRTFTPLLGAEIVVEPRATLTLGVDAAFEHGLLVDSGDVRLSDTVLRPAELGYVPRGAETLTMVNETDAPARTILLGGPPFEEEIVMWWNFIGRSHEDIVKAREDWEAASTDRFGVVEDFPGGRLPAPTLPNAVIRPRRNPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK35</accession>
    <name>Q9AK35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4891</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629044.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974081.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100332"/>
    <dbReference type="KEGG" id="sco:SCO4891"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4971"/>
    <dbReference type="eggNOG" id="ENOG502ZFNA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1958288_0_0_11"/>
    <dbReference type="OMA" id="NCADINV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176625" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="128" mass="13760" checksum="BA473A4469BA44C4" modified="2001-06-01" version="1">MRTRTKLTTVLASGTLAAGLLVGGASSASAGTAQTCYGGAVDFSTTNKVWPAYPQWRTTSARCADVNVKATVGAYVQACFYQGAGEPHKCYAKRWLSQGVWDTAVTDVLNGKKFYLKFDRSTWGKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK92</accession>
    <name>Q9AK92_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system DNA binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1370</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625654.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977456.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1370"/>
    <dbReference type="GeneID" id="1096793"/>
    <dbReference type="KEGG" id="sco:SCO1370"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1378"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9AK92"/>
    <dbReference type="OMA" id="SHLVHVY"/>
    <dbReference type="PhylomeDB" id="Q9AK92"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="21990" checksum="8BA401A115FC62FA" modified="2001-06-01" version="1">MTDSPVRLLLADDHPVVRAGLRAVLETEPGMVVVAEAATAEEAVTRAARGDVDVVLMDLQFGKGMNGAEATAAIAARPGAPRVLIVTTYDSDADTLPAIEAGATGYLLKDAPPEDLADAVRTAAAGRTALAPAVADRLMHRLRTPGTTLTRRETEVLALVADGLSNQAIGRRLHLTEGTVKSHLARVYAKLDVDSRTAAVATAGSLGLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWL3</accession>
    <name>Q9EWL3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7777</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631809.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031903.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7777"/>
    <dbReference type="ESTHER" id="strco-SC5E9.25c">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1103214"/>
    <dbReference type="KEGG" id="sco:SCO7777"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7894"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847819_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWL3"/>
    <dbReference type="OMA" id="ARITSGH"/>
    <dbReference type="PhylomeDB" id="Q9EWL3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="34025" checksum="676AFABDD8E2D95E" modified="2001-03-01" version="1">MVTSPALRDVHVPHAYPEQQVDLGEITMNYAEAGDPGRPAVLLIPEQTGSWWSYEEAMGLLAEHFHVYAVDLRGQGRSSWTPKRYSLDNFGNDLVRFIALVVRRPVVVAGNSSGGVLAAWLSAYSMPGQIRGVLCEDPPFFASELVPAHGHSVRQGAGPVFELFRTYLGDQWSVGDWEGFRSAADASASPMARSFVADTIPQHLKEYDPEWARAFYEGTVGLNCPHERMLNRVNTPVLLTHHMRGTDPETGNLLGALSDEQAAQVRRLMESAGVKVDYESVPDASHMMHQSDPARYAEILTPWTAALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWP7</accession>
    <name>Q9EWP7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7680</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031825.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7680"/>
    <dbReference type="GeneID" id="1103118"/>
    <dbReference type="KEGG" id="sco:SCO7680"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7799"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_11"/>
    <dbReference type="InParanoid" id="Q9EWP7"/>
    <dbReference type="OMA" id="QFRRIQM"/>
    <dbReference type="PhylomeDB" id="Q9EWP7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="296"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="328"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC17497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="541" mass="55538" checksum="429548A6A562D0D3" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWW1</accession>
    <name>HUTH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine ammonia-lyase</fullName>
            <shortName evidence="2">Histidase</shortName>
            <ecNumber evidence="2">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hutH</name>
        <name type="ordered locus">SCO4932</name>
        <name type="ORF">SCK13.24</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Cys-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974041.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9EWW1"/>
    <dbReference type="SMR" id="Q9EWW1"/>
    <dbReference type="STRING" id="100226.SCO4932"/>
    <dbReference type="PRIDE" id="Q9EWW1"/>
    <dbReference type="GeneID" id="1100373"/>
    <dbReference type="KEGG" id="sco:SCO4932"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5011"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_1_11"/>
    <dbReference type="InParanoid" id="Q9EWW1"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="PhylomeDB" id="Q9EWW1"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:histidine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161037" description="Histidine ammonia-lyase">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Cys-Gly)" evidence="1">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <sequence length="512" mass="52776" checksum="C44CBEED6BB49231" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F336</accession>
    <name>Q9F336_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5134</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629283.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030076.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5134"/>
    <dbReference type="GeneID" id="1100575"/>
    <dbReference type="KEGG" id="sco:SCO5134"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5217"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048109_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F336"/>
    <dbReference type="OMA" id="WTGRANS"/>
    <dbReference type="PhylomeDB" id="Q9F336"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="344" mass="36236" checksum="AD090B0BBFD48E37" modified="2001-03-01" version="1">MEFSAAGRLEVRITTADVGKRVSVRRLSEAGAAGEKFTDTVGVLTSWTDGVLLITRKSGESVRVAESALVAGKVVPPAPARRRGPAASYEELARVAARSWRPVESERLGAWELRAAGGFTRRANSVLPLGDPGLPLDEALTAVRRWYGVRGLPAYVQTATGAAGTQELLCAELERRGWVREVTAEVWTGPLAPVADLAGDTGVVLSREADETWLARYQRKGVSEVALRVLESGPSVWFATVPGAEGADGAGGGGGVAAIGRCVVDGRWASFAAVEVDPAQRRRGLATAVMAALARRALDEGASAAWLQVETDNAGARALYAGMGFAAHHSYHHYREPAAAGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F350</accession>
    <name>Q9F350_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative peptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5120</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629269.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030066.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5120"/>
    <dbReference type="TCDB" id="3.A.1.5.35">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100561"/>
    <dbReference type="KEGG" id="sco:SCO5120"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5203"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="Q9F350"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="PhylomeDB" id="Q9F350"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC05750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="35954" checksum="88C304BFDBF6E821" modified="2001-03-01" version="1">MLLEVRDLHVEFHTRDGVAKAVNGVSYGVDAGETLAVLGESGSGKSVTAQTIMGILDIPPGRVTAGEILFEGRDLLKLKEEERRKVRGAEMAMIFQDALSSLNPVLTVGAQLAEMFTVHRGMSRKDAHAKAVELMDRVRIPAAKERVRQYPHQFSGGMRQRIMIAMAMALEPKLIIADEPTTALDVTVQAQVMDLLAELQRELHMGLILITHDLGVVADVADKIAVMYAGRIVETAPVHDIYKAPAHPYTRGLLESIPRLDQKGQELYAIKGLPPNLTRIPPGCAFHPRCPMAQDVCRTDVPPLYDVTESDAERGSACHFWRECLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBP7</accession>
    <name>Q9FBP7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5029</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629181.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973948.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5029"/>
    <dbReference type="GeneID" id="1100470"/>
    <dbReference type="KEGG" id="sco:SCO5029"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5107"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059319_2_0_11"/>
    <dbReference type="OMA" id="KWGLSYM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325426" evidence="2">
        <location>
            <begin position="39"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC05874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="25184" checksum="EB3B2D2D4E52B56B" modified="2001-03-01" version="1">MLEGNRVSRISVRGFAVASATAVTAVGSVVGVASGSVAQNNDDAEATAAGTTLLADIPMGEQAQVQTASLTQQADVQAIAADASAKKDAEEAARKAAAKTAVDKQEKAKKAAQAAKQREAQQEAASRDAKRESTSFAVQSSYSTSQIQAMARQMVPSGQFQCFSNIVNHESSWNYQAVNASSGAYGLFQALPAGKYASAGADWRTNPATQIKWGLSYMDNRYGSPCDAWAFWQANHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBR6</accession>
    <name>Q9FBR6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5279</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC04494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629424.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973690.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5279"/>
    <dbReference type="GeneID" id="1100720"/>
    <dbReference type="KEGG" id="sco:SCO5279"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5364"/>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055445_0_0_11"/>
    <dbReference type="OMA" id="NACHSGR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="224"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="44796" checksum="2E26244947C7916D" modified="2001-03-01" version="1">MARRPAASVLNLRRAQEPPAGLGGTDARPGARLEDGFAVLRVLRADGADGLPGYRLQGWCGDLSVTCAAGPTRRPAPAVSLARLRQDGDGHYPSEVLRGIRLWSDNQYELAGWVNRIRARHGDDLRLVVWDDTGYDLPWELLLLPGDAAAGLAGGPLGAVIAVARWTTVRDLSQGGLPAETGDCHGRVLGYLHQDMADDGRVFTSYAHRLHRRMTPFLSDLDTQDDRTGLVYLGCHGTYGEAVPGLTLGDRTWAELNGESMSVLRRDGSLVCLNACDSGRFVDNRAQGEEALRGFAELFLRKGAGGCIVSSGKVGDLEARAMARRLVREVAEHPRRPVVRTLRDFRVRALEEFGSLAELPRVRNDDGQVDVVGQKRVLRLLYAFMFHYYGHPGTALRLTAVDALGTEGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC53</accession>
    <name>Q9FC53_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631194.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031450.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7133"/>
    <dbReference type="GeneID" id="1102571"/>
    <dbReference type="KEGG" id="sco:SCO7133"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7233"/>
    <dbReference type="eggNOG" id="ENOG5032947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148719_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="113" mass="12712" checksum="CE9D87326F485987" modified="2001-03-01" version="1">MDTSKQAARGLADIQAFLYREAHLSAARRRVSAFAARADGLTHGQRMDLERWYLEEQKYVARMVTEHIEERIGAAEAAHRLRFGRWLRGTMIAMTAIGLTIFVCTAVVVGSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC63</accession>
    <name>Q9FC63_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7123</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631184.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031446.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7123"/>
    <dbReference type="GeneID" id="1102561"/>
    <dbReference type="KEGG" id="sco:SCO7123"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7223"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_11"/>
    <dbReference type="InParanoid" id="Q9FC63"/>
    <dbReference type="OMA" id="TPIFMEA"/>
    <dbReference type="PhylomeDB" id="Q9FC63"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC04229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="417" mass="42520" checksum="C69B520EDF8FF372" modified="2001-03-01" version="1">MTVSVTLPALGESVTEGTVTRWLKQVGDRVEADEPLLEVSTDKVDTEIPSPAAGVLLEILAAEDETVEVGAGLGIIGAPDTAPAAPAAPAAPAPAPAPTPTPTPTPTPTASAPAPTPAPAPAPAPAPAPAEPFVPPAASAVPAPPAPAPAPTTPQAPAPAPAPVRAAPAEDASSLRGRTVAMTRIRRAIGNNLKKALLEQAQLTSTVEADVTRLMRLRNRAKDGFLAREGLKLSPMPFFVKAAAQALKAHPVVNARINEDEGTITYFDSENIGIAVDTEAGLMTPVVKAAGDLTVAGLARAVHDLADRARGGHLTPDDVSGATFTISNTGSRGALFDTVIVPPNQAAILGVGATVRRPGVVRVGDEEVIGVRDLVHLSLSYDHRLVDGADAARYLTAVKALLESAAFEDDLYPDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3P4</accession>
    <name>Q9K3P4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1104</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625398.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977728.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1104"/>
    <dbReference type="GeneID" id="1096527"/>
    <dbReference type="KEGG" id="sco:SCO1104"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1101"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102569_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3P4"/>
    <dbReference type="OMA" id="HRLMHRT"/>
    <dbReference type="PhylomeDB" id="Q9K3P4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB95991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="26109" checksum="240E6A340F278227" modified="2000-10-01" version="1">MSPRSASVNEELRRRSKERLLQAAVELVGERGYEATTLGDIADRAGSARGLVSYYFPGKRQLVQSAVHRLMHRTLEEALEREPRTADGRERLARAVDAILGLARDRPVLMRQHMAGLLQAEVGFVPCPEQRRLAELLRDTVARHGSRDVDRDYPMLRAQLMGAVFAALVPGVPMPVPELRAELFERYRLDWKLGVPPDAETPGGTTCDPDLSRFFATGVPDRQDRTDRSPQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3T5</accession>
    <name>Q9K3T5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3129</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627346.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975684.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3129"/>
    <dbReference type="GeneID" id="1098563"/>
    <dbReference type="KEGG" id="sco:SCO3129"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3193"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_2_11"/>
    <dbReference type="InParanoid" id="Q9K3T5"/>
    <dbReference type="OMA" id="HLVNLCW"/>
    <dbReference type="PhylomeDB" id="Q9K3T5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB95922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="24875" checksum="D8B8405185A34CD7" modified="2000-10-01" version="1">MIDAVATDSSSTPSNEKPRRARRTRMTGAERRQQLLEIGRTLFAAKGFEGTSVEEIAAKAGVSKPVVYEHFGGKEGLYAVVVDREMRRLLDMVTGSLTAGHPRELCEQAAFALLDYIEEYTDGFRILVRDSPIPQSTGTFASLISDIATQVEDILGREFKNRGFDAKLAPLYAQALVGMVALTGQWWLDVRRPKKAEVAAHLVNLAWHGLDGLEPKPRLIGHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X7</accession>
    <name>Q9K3X7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1357</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625642.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1357"/>
    <dbReference type="GeneID" id="1096780"/>
    <dbReference type="KEGG" id="sco:SCO1357"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1365"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_5_0_11"/>
    <dbReference type="InParanoid" id="Q9K3X7"/>
    <dbReference type="OMA" id="HDGRHAW"/>
    <dbReference type="PhylomeDB" id="Q9K3X7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="153" mass="17607" checksum="271A3D667BA3EA80" modified="2000-10-01" version="1">MTQRRGRRITMTPGELEAFLTTRRTCRVATVSADGAPHVSTLWFVWDGASMWLYSVVRSRRWADLRRDPRVAIVVDTGEEYDELRGVELSGRVAFVGEAPRTGELCAELDFPETLFARKNFGLQEMPHDGRHAWLRLTPEEVVSWDFRKLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K495</accession>
    <name>Q9K495_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629375.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030124.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5228"/>
    <dbReference type="GeneID" id="1100669"/>
    <dbReference type="KEGG" id="sco:SCO5228"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5311"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102964_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K495"/>
    <dbReference type="OMA" id="RTPERDW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="18156" checksum="73CF49B9B9DB8400" modified="2000-10-01" version="1">MDFVIRRATAEEYDTLGEITAQAYLRDGLLDFGESDSYLDELRDVAKRAAAAEVLVAVADDAVLGGATFVPSGGPMADIARPGEAEIRMLAVAREARGRGAGEALVRACADRARAVPGCTGVVLSTQAAMRTAHRLYERLGFVRTPDRDWNPLPELDDIMLLTYELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4J4</accession>
    <name>Q9K4J4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631375.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031586.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7320"/>
    <dbReference type="GeneID" id="1102758"/>
    <dbReference type="KEGG" id="sco:SCO7320"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7423"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_8_11"/>
    <dbReference type="InParanoid" id="Q9K4J4"/>
    <dbReference type="OMA" id="AKPGAML"/>
    <dbReference type="PhylomeDB" id="Q9K4J4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="360"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="580" mass="61544" checksum="BC7E7EC2332DB051" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXI7</accession>
    <name>Q9KXI7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626580.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028288.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2333"/>
    <dbReference type="GeneID" id="1097767"/>
    <dbReference type="KEGG" id="sco:SCO2333"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2370"/>
    <dbReference type="HOGENOM" id="CLU_3048490_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="54" mass="5709" checksum="A7DEA718C2709EF1" modified="2000-10-01" version="1">MRNRPALEPHRLAALRPRHATVAVRDSKTPAGRGLTLTPAAFTAFVGWATATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXJ0</accession>
    <name>Q9KXJ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626577.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028285.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2330"/>
    <dbReference type="GeneID" id="1097764"/>
    <dbReference type="KEGG" id="sco:SCO2330"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2367"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_1_11"/>
    <dbReference type="InParanoid" id="Q9KXJ0"/>
    <dbReference type="OMA" id="TGMMTHM"/>
    <dbReference type="PhylomeDB" id="Q9KXJ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="20687" checksum="D1AB88BAA07C7197" modified="2000-10-01" version="1">MPRTTLRRLSGLDDTPAKLADSTLVLVDYQNTYTTGVMELDGWQAALDAGARLLARARREGARVVHVVHDGGEGSPYDLGAEIGQIHPSVAPVDGEPVVTKKAPDSFFGTDLGEHVDAAGNNDLVVVGFMTHMCVAFTAQGAFLRGNRPTVVADACATRALPVADTELDARQVHYGALATVADMYGVVVPSQESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK5</accession>
    <name>Q9KXK5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626562.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976498.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2315"/>
    <dbReference type="GeneID" id="1097749"/>
    <dbReference type="KEGG" id="sco:SCO2315"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2352"/>
    <dbReference type="eggNOG" id="ENOG5033GJH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146066_1_1_11"/>
    <dbReference type="OMA" id="WILMYLL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="97" mass="10626" checksum="FD88DFF9EB264B5A" modified="2000-10-01" version="1">MSPRTRSGSHSAGTAVAVIADIMAFILGLWILMYLLDANRANDLVRFVHDAANWLAGWSHDLFTFDEAWARVVAGYGLAAVVYLFVGHAVANRLHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXR4</accession>
    <name>Q9KXR4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1485</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625765.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977341.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1485"/>
    <dbReference type="GeneID" id="1096911"/>
    <dbReference type="KEGG" id="sco:SCO1485"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1494"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114150_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXR4"/>
    <dbReference type="OMA" id="FVALVYW"/>
    <dbReference type="PhylomeDB" id="Q9KXR4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="191" mass="20638" checksum="BFA892D686E27FEF" modified="2000-10-01" version="1">MTSVAPVILLAAEKESAEVTDWAARVGWVVGLGLFVALVYWLMREGWKWRGTLQGDLPELPAAPDEPGPAKLSMSGRYHGSTTAGQWLDRIVAHGLGTRSRVELTLTDAGLDVVRPGAADFFVPVAALREARLDKGIAGKVLTEGGLLVVTWAHGDKLIDSGFRSDHAAEHNEWVDTLNDMINKTETEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU1</accession>
    <name>Q9KXU1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628472.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029565.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4300"/>
    <dbReference type="GeneID" id="1099740"/>
    <dbReference type="KEGG" id="sco:SCO4300"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4368"/>
    <dbReference type="eggNOG" id="ENOG5033NX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_0_1_11"/>
    <dbReference type="OMA" id="CLEVARW"/>
    <dbReference type="PhylomeDB" id="Q9KXU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="89" mass="9451" checksum="8BAA77DEC9B2B134" modified="2000-10-01" version="1">METTPEYDWYKSSYSGGSGDNCLEVARWRKSTHSGGSGGNCLEVATGNTAVPVRDSKNPVGPTLRFRAEAWSVFVDGIRRGGVSGPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU9</accession>
    <name>Q9KXU9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974682.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4292"/>
    <dbReference type="CAZy" id="GT81">
        <property type="family name" value="Glycosyltransferase Family 81"/>
    </dbReference>
    <dbReference type="DNASU" id="1099732"/>
    <dbReference type="GeneID" id="1099732"/>
    <dbReference type="KEGG" id="sco:SCO4292"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4360"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053119_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXU9"/>
    <dbReference type="OMA" id="HRHQDGQ"/>
    <dbReference type="PhylomeDB" id="Q9KXU9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="33966" checksum="E7509CF17DD5952D" modified="2000-10-01" version="1">MLEEVERWLDARSWPAADRPVQHLLSAKHATGQSVSVVLPALDEEATVGDIVSVIRRELVLGVPLVDEIVVVDSGSSDRTSEVAAAAGARVVHRDAILPRIPAVPGKGEVLWRSLLVTGGDIVCFVDADLREFSADFVSGIVGPLLTDPDVHLVKAMYDRPLAGAAGQGGRVTELMARPLLNMHWPQLAGFVQPLGGEYAARRSLLERLPFPVGYGVELGMLVDALHLVGLDALAQVDVGVRVHRHQDGRALGRMAAAIYRTAQLRLARGHLVRPALTQFERGVDGFEPRTYAVDTEERPPMTEIAEYAARKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXX8</accession>
    <name>Q9KXX8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628057.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975063.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3870"/>
    <dbReference type="GeneID" id="1099306"/>
    <dbReference type="KEGG" id="sco:SCO3870"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3944"/>
    <dbReference type="eggNOG" id="ENOG5031SGD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2829220_0_0_11"/>
    <dbReference type="OMA" id="ADGYEQY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045643">
        <property type="entry name" value="DUF6405"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19943">
        <property type="entry name" value="DUF6405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="66" mass="6962" checksum="250EAAD88FB20415" modified="2000-10-01" version="1">MTKGPFVAMAGATAALGTALGSLALQLRADGYEQYVESVATFSILMFVTSALTVVTWVRDGRPHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY95</accession>
    <name>Q9KY95_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative septum site-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629159.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973970.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5007"/>
    <dbReference type="GeneID" id="1100448"/>
    <dbReference type="KEGG" id="sco:SCO5007"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5086"/>
    <dbReference type="eggNOG" id="COG4963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151994_0_0_11"/>
    <dbReference type="OMA" id="LGMTPTI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="13554" checksum="F635E3C4EB4F8676" modified="2000-10-01" version="1">MSGLRGRDRARDGGQVTIEFLGMTPVIIATLVVLWQLVLVGYTYTLAGNAADEAVRAATAAERGARQGACREAGLDKLPGSWEGGASVGCDAAGGFVTADVRIEVPLLFPGTLSLPFTVHGHAGAVEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI7</accession>
    <name>Q9KYI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-binding protein SCC61A.06c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2685</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626919.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028513.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2685"/>
    <dbReference type="GeneID" id="1098119"/>
    <dbReference type="KEGG" id="sco:SCO2685"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2741"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019886_1_0_11"/>
    <dbReference type="OMA" id="DRVPHQV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="1">
        <location>
            <begin position="65"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="535" mass="58135" checksum="6816E0A6A0B84A62" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYU2</accession>
    <name>Q9KYU2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LigB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3204</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627418.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975613.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3204"/>
    <dbReference type="GeneID" id="1098638"/>
    <dbReference type="KEGG" id="sco:SCO3204"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3264"/>
    <dbReference type="eggNOG" id="COG3384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046582_2_1_11"/>
    <dbReference type="InParanoid" id="Q9KYU2"/>
    <dbReference type="OMA" id="RTEHFAP"/>
    <dbReference type="PhylomeDB" id="Q9KYU2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB90988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="27383" checksum="9868FDDCCCAF414E" modified="2000-10-01" version="1">MPALYLSHGAPPLADDPVWPGELAAWAADLPRPKAILVVSAHWEEAPLALGATRTVPLVYDFWGFPEHYYQVRYGAPGAPALAESVRKLLRAPGTPVQDVPDRGLDHGAYVPLVEMYPGADIPVLQVSMPTLDPARLMEIGRRLAPLRDEGVLIVGSGFFTHNLAALRQGGIPSWSAEFDDWGRRALEGGDVDGLLDFAHKSPAGRLAHPRTEHFAPLFVTMGAADAAGELDLRRSVIDGFWMGLAKRSVQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYX1</accession>
    <name>Q9KYX1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3010</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627232.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028713.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3010"/>
    <dbReference type="GeneID" id="1098443"/>
    <dbReference type="KEGG" id="sco:SCO3010"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3069"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KYX1"/>
    <dbReference type="OMA" id="PATRWCP"/>
    <dbReference type="PhylomeDB" id="Q9KYX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB90921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="32077" checksum="ED6E250FDAE5A3C1" modified="2000-10-01" version="1">MRGLRTCLTRRTWRRGWADLTDLVLPAECGGCGTARAVLCPRCRTALSGAPPCRVRPEPEPPGLPAVHAAAPYADEVRAALLAHKERGVLALTAPLGVALAQAVRAALREAGTDAGDVRTGAVGAGAAGPAPGRGPVLLVPVPSARRAVRTRGHDPARRIALAAAGELRRTGTSARVLAVLRQRYAVADQSGLDARRRLDNLAGALAVAPGGAGPLREGGTVVLVDDLMTTGASLAEAARAVRAATAAAVESPAGSDAYRTARSAVYPAAAGEGREERKTGPRMAGPYGGGGVIREAICAAVVAASPDSFEINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZI5</accession>
    <name>Q9KZI5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1160</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625452.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027618.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1160"/>
    <dbReference type="GeneID" id="1096583"/>
    <dbReference type="KEGG" id="sco:SCO1160"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1158"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002554_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KZI5"/>
    <dbReference type="OMA" id="PGRAWRM"/>
    <dbReference type="PhylomeDB" id="Q9KZI5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="4">
        <location>
            <begin position="110"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="581"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="862" mass="91913" checksum="574439F46835817D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZU7</accession>
    <name>Q9KZU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4154</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628331.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029470.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4154"/>
    <dbReference type="GeneID" id="1099594"/>
    <dbReference type="KEGG" id="sco:SCO4154"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4218"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_5_11"/>
    <dbReference type="InParanoid" id="Q9KZU7"/>
    <dbReference type="OMA" id="ISGQFSH"/>
    <dbReference type="PhylomeDB" id="Q9KZU7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901565">
        <property type="term" value="P:organonitrogen compound catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14513" checksum="A2E85A44451365D1" modified="2000-10-01" version="1">MTTHDVFRFDVPAEDDFGYSQAIGSGELVHVSGQLAFDEAGEFPDGGDFAAQLRRTHANMDRVLEHYGATRNQIVSQTQYVVDLRQHAAAVARGNLAYFGEHRPASTVLGVTELTLPGQVVEIGFVIDLRLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZZ8</accession>
    <name>Q9KZZ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4428</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628595.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029647.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4428"/>
    <dbReference type="GeneID" id="1099868"/>
    <dbReference type="KEGG" id="sco:SCO4428"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4497"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032306_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZZ8"/>
    <dbReference type="OMA" id="DWRYRAR"/>
    <dbReference type="PhylomeDB" id="Q9KZZ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="54155" checksum="85F334330B0D4C9B" modified="2000-10-01" version="1">MCEDDHENDHAGIGRRAVFVTGAAAALTLSTVSFASAAGGTGPRTRTVRGTLPPGSPDFVYVPVEVPRGVREIHVAYTYDRPTVPAGTQGNALDIGLFDERGTDLGGRGFRGWSGGARTEFFVRADDATPGYVPGPVRAGTWHIALGPYTVAPQGLSYEITITLTYGEQGETPRPVYPPERASGRGRAWYRGDCHLHSEYSDGCYTLAEIARLARAAGLDFINSSEHNTHSAHAHWAGLAGDDLLILLGEEVTTRNGHVVALGTDPGTFVDWRYRARDNRFGRFARQIRRAGGLVVPAHPHATCIGCNWKFGFGEADAVEVWNGAYTPDDEVALADWDGMLVASVRDGRRDWIPAMGSSDSHRSPDVIGRPQTVVLADDLTREAIQEGIRAGRSYVAESSKVSLSLTASGGRGEHAGIGERLRVDADTPVTVRLEVTGAPRCTVRLVTDQGVLFTSDPLPVSGAGTVQWRTTASYAAYVRAEVRHEAAAGPLPGALAAFTNPVFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L029</accession>
    <name>Q9L029_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7026</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631090.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031389.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7026"/>
    <dbReference type="GeneID" id="1102464"/>
    <dbReference type="KEGG" id="sco:SCO7026"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7130"/>
    <dbReference type="eggNOG" id="COG1942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L029"/>
    <dbReference type="OMA" id="QIVHQHP"/>
    <dbReference type="PhylomeDB" id="Q9L029"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037479">
        <property type="entry name" value="Tauto_MSAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38460">
        <property type="entry name" value="PTHR38460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14552">
        <property type="entry name" value="Tautomerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="16873" checksum="B913384108B2F8D5" modified="2000-10-01" version="1">MPLITVSLRQGTTPQYRRLVSEALHKSMVDVLKIPQDDQFHVFHEVTDDNFVMQPVVFGLRRTSRTLFIQLSFNRRGAEQKARLFRAIVANLRLYADVPEEDVMLVAFETARENWWAAGRVVDPATGYDERMTDVPALPDVSEEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L037</accession>
    <name>Q9L037_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7018</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031382.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7018"/>
    <dbReference type="GeneID" id="1102456"/>
    <dbReference type="KEGG" id="sco:SCO7018"/>
    <dbReference type="eggNOG" id="COG4469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548480_0_0_11"/>
    <dbReference type="OMA" id="VCHFAHR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="505" mass="55328" checksum="4B3B9EFD033B6EA4" modified="2000-10-01" version="1">MSGPDSRLVQTAVIGSPNSGRAIILPTDADELLRWRRGHRASTYWCGTQLGGCGNELSDRLYRDKVCHFAHRPHTSCHRTATGASSADHLFIKDDLVAWTGRLGIRGRATSRDLGSGPGDAVDFRAGKGGQQHVRFQFSKLSHAEWTSTRDRLTGEATTLDWVFGPSTVQPETVEALCDEYGYLFRFRFETHGAARHIRLRAEDPRNSTEWVPLRACAMTPEGLRVPGAELRRRTSGSRPLDVAGVAAAPRSRDDQVRALRRALISAARFRARPTWEVLCRTAGGDLLKVSSQDRVGLLLAVEQAGEEGTPLLSALLRTGAGEPPPYIREVVAAAGGGAPATAQVLKRWCQRETDRAFAVYGMPSRTAPARLALTTDGRIAAQTAEPATRRTIVHVEARASALEVTPLSEALRGARERQDGRLVVGLLEQAEDSIVTLPKPERTKLLREMRTARDWLNSGVTKRRRKRQAPANPAGKARAKKKGGTLRDARPLPGLEEKPKKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L088</accession>
    <name>Q9L088_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2458</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86123.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626701.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976346.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2458"/>
    <dbReference type="GeneID" id="1097892"/>
    <dbReference type="KEGG" id="sco:SCO2458"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2500"/>
    <dbReference type="eggNOG" id="ENOG5033YWX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100609_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L088"/>
    <dbReference type="OMA" id="WRTWHTY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024486">
        <property type="entry name" value="DUF2617"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10936">
        <property type="entry name" value="DUF2617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB86123.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="18264" checksum="B27186159F483B9B" modified="2000-10-01" version="1">MHAVSLQAAFLDTAADQLCFSLDLTELPALAEREVSVGGLAVRLRLLGASHQVFAGPVRETVACLPEAVRGLPTTLTRQPAGWTYDFSAVTECLDPAEFSARVADALSRADEAEHSLSGVFPGSPEAVTAVVVEACDEGLGGADRPGLAWRTWHSYPQDGHIVSTHSRLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0S5</accession>
    <name>Q9L0S5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628683.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029705.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4519"/>
    <dbReference type="GeneID" id="1099959"/>
    <dbReference type="KEGG" id="sco:SCO4519"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4591"/>
    <dbReference type="eggNOG" id="ENOG5032BKT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377466_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="22196" checksum="8A758AF37AF3E34D" modified="2000-10-01" version="1">MDERHLLNELMKAVAEEAREFTVRPHFPGLKKFAAFAYVAESFGYRYVGHAPGNAALNNPFFLFVRMPDARTRATALQAAHQRAPGRTPLPGMRPGLGLTPVPEARPRVELLYSQMVVDASGRYNPRVLSNILILPVVMAIFLIFPGYTVRNVLVAVGIWVVFFAFYLVGLGVTRRRRRTHLNRLSAAGVEWPPRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0T4</accession>
    <name>Q9L0T4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628674.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029701.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4510"/>
    <dbReference type="GeneID" id="1099950"/>
    <dbReference type="KEGG" id="sco:SCO4510"/>
    <dbReference type="HOGENOM" id="CLU_1884559_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14396" checksum="BA42F302DA7C4C72" modified="2000-10-01" version="1">MRHLADRPDIVPSDSLSPALREAVETFAADRGPDALPPLVVGNACGCYRIEVLTPGASVAFYGMHARARIVDAGGREMEMDSYHLEDLSVEDLWLWKSLFRPTPPPAGASAGQPGGRPLPDGRGSPGVRPPGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Z2</accession>
    <name>Q9L0Z2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1467</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625748.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027801.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1467"/>
    <dbReference type="GeneID" id="1096893"/>
    <dbReference type="KEGG" id="sco:SCO1467"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1476"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564765_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0Z2"/>
    <dbReference type="OMA" id="CDAWGIG"/>
    <dbReference type="PhylomeDB" id="Q9L0Z2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="57"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="491" mass="52224" checksum="02EE5C012FA5D81D" modified="2000-10-01" version="1">METGTPRTGEAAGQVAAGLEISQWKYLPGEAGDPQMHAILSVRVDGTGGDGHPGGPVLAQVLVMDCSSSMTWPVEKLHAAQRAAVAAIRKLPDGTPFAVVRGNEQAAVVYPDTPRMARASARTRSRAERAVRETVAGGGTCIGAWLDLSRRLLTEQDAPIGHVLLLTDGKNQHDEQMPLARVLEECAGRFVCDAWGIGDGWDGRELLRITSRLHGSASSVREEEALPGEYEQLMNRLLTKTVPELVVSVTAMPGCTVRYLKQVFPTEAELTAEDGTGRFVTRAWGDETRRYQLCLAADPTGRPRGEDLQLAVVAVDVPGGREVRLPPPRPCLVHWTDDPALSRHTDAQVEHFEQHQRLGEAVAAATDAHRRGQRDLAEQQLGRAVRLAHAMGADEQLTRLARLVRIQDAPSGRVALRPEVTAVDFQHLITASSHSTYGPASGTGTGVGTGSGAAGGAPGGGATVPCPACSRKAPAAARFCPACGHRFGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L120</accession>
    <name>Q9L120_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7440</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031667.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7440"/>
    <dbReference type="ESTHER" id="strco-SC6D11.36C">
        <property type="family name" value="CFTR-inhibitory-factor_Cif"/>
    </dbReference>
    <dbReference type="GeneID" id="1102878"/>
    <dbReference type="KEGG" id="sco:SCO7440"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7550"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_11"/>
    <dbReference type="InParanoid" id="Q9L120"/>
    <dbReference type="OMA" id="YPWAAQF"/>
    <dbReference type="PhylomeDB" id="Q9L120"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="33938" checksum="B302100E5CE852C7" modified="2000-10-01" version="1">MTDDATAPSSSCDQNPVPGLPLHDLAGFTHRWVDAEGIRLHAVEGGRPAGPTVVLLAGFPQTWWAWRKVMPGLAARFRVIAIDLPGQGHSERPRGGYDTHTVASRVQTALTALDVPKYWLVGHDVGAWVAFSLALKYEERLHGVALLDAGIPGITLPDSIPTDPDRAWKTWHFAFHLVPELPETLLTGRERDYVDWFLKVKTLSPDTFDGAEIDHYAAAVAAEGGLSASLAYYRDAAESARRNHDALERGHLTVPVLGVSGSHGSIPDMAASIGPWAANATGAVIPQAGHFIPDEQPEATVKVLTAFIDYERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L122</accession>
    <name>Q9L122_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7438</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631487.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031665.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7438"/>
    <dbReference type="GeneID" id="1102876"/>
    <dbReference type="KEGG" id="sco:SCO7438"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7548"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_39_0_11"/>
    <dbReference type="InParanoid" id="Q9L122"/>
    <dbReference type="OMA" id="VLQQTDM"/>
    <dbReference type="PhylomeDB" id="Q9L122"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="34370" checksum="581C4CAD64F8EA2D" modified="2000-10-01" version="1">MGTFDLNLARVFVLLYETGSVTATAETLHVTQPTVSYSLGKLRRHFDDELFRRNGRGLTPTAGARRLYLPLQRALAEIDGTVRQGDLFDAGSMSGRFTIALSDLGEATLLPRLVATARERAPGVSFTVRPFDVEDAEGQLRRGDLDAFVATPVITSHLTVRIPLFRERYVLMVAADHPRVRGDAVTPEDLAAEHHATVFGPSGHVTPRALLGAHGLLERVAVDATRFSMLPYLLEQTDLVAIVPEYVGEVFTASHRVRLVRLPFETEPIEIALYARHESSRSPAQRWLVQFMAEVLGEQVSPAQLPPSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L142</accession>
    <name>Q9L142_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P450-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2003" name="J. Biol. Chem." volume="278" first="12214" last="12221">
            <title>The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems.</title>
            <authorList>
                <person name="Podust L.M."/>
                <person name="Kim Y."/>
                <person name="Arase M."/>
                <person name="Neely B.A."/>
                <person name="Beck B.J."/>
                <person name="Bach H."/>
                <person name="Sherman D.H."/>
                <person name="Lamb D.C."/>
                <person name="Kelly S.L."/>
                <person name="Waterman M.R."/>
            </authorList>
            <dbReference type="PubMed" id="12519772"/>
            <dbReference type="DOI" id="10.1074/JBC.M212210200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631466.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031650.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="PDB" id="1GWI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.92 A"/>
        <property type="chains" value="A/B=1-407"/>
    </dbReference>
    <dbReference type="PDBsum" id="1GWI"/>
    <dbReference type="SMR" id="Q9L142"/>
    <dbReference type="STRING" id="100226.SCO7417"/>
    <dbReference type="GeneID" id="1102855"/>
    <dbReference type="KEGG" id="sco:SCO7417"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7527"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L142"/>
    <dbReference type="OMA" id="HVLIRFA"/>
    <dbReference type="PhylomeDB" id="Q9L142"/>
    <dbReference type="EvolutionaryTrace" id="Q9L142"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036199">
        <property type="term" value="F:cholest-4-en-3-one 26-monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="1GWI"/>
        </source>
    </evidence>
    <sequence length="407" mass="43876" checksum="DF3DD8C914AFA7BC" modified="2000-10-01" version="1">MTTGTEEARIPLDPFVTDLDGESARLRAAGPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHRRLRTLVAQALTVRRVEHMRGRITELTDRLLDELPADGGVVDLKAAFAYPLPMYVVADLMGIEEARLPRLKVLFEKFFSTQTPPEEVVATLTELASIMTDTVAAKRAAPGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEAEWSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVTQNDLFELPVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1M8</accession>
    <name>Q9L1M8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6887</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630957.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031272.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6887"/>
    <dbReference type="GeneID" id="1102326"/>
    <dbReference type="KEGG" id="sco:SCO6887"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6998"/>
    <dbReference type="eggNOG" id="ENOG5031D6X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634399_0_0_11"/>
    <dbReference type="OMA" id="NAWRIVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="17712" checksum="A05A56F1CB0EBD75" modified="2000-10-01" version="1">MSAGAGQPAFALSFDPRALTDLLQAPSDIRDLTLAYLQEVVNAQRFGQRLDGDLEGFRKLFVDRRKDWRVVYGVRPAPAESIHSKEIHVVAVRPRAGNDVYDEVGRRLGMTRRPLSARTHAARSRSPQLTTRAPVPRPGPPPAALPGPPRPAPNPAHHPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1N9</accession>
    <name>Q9L1N9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6876</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630946.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031261.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6876"/>
    <dbReference type="GeneID" id="1102315"/>
    <dbReference type="KEGG" id="sco:SCO6876"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6987"/>
    <dbReference type="eggNOG" id="ENOG5031XY1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585564_0_0_11"/>
    <dbReference type="OMA" id="GNGIWVW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB72381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="19296" checksum="D5687C8285003B81" modified="2000-10-01" version="1">MNFTSDPVLRKIALEAAQQVTTDTGRIHQDELLEALCERLAPRKELLGLVIKKAGQAMMRDLGERHSPRRNRTPNGFYHPKSIMKLGNGIWVWMKDSTFTDMTEWGRISSRNFVRTATAEAHKQEYVSSRIDAYRENPQFTRLAPLEETVFGFRQDSFDDLGFDSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1V3</accession>
    <name>Q9L1V3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyll-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6832</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630903.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031217.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6832"/>
    <dbReference type="GeneID" id="1102271"/>
    <dbReference type="KEGG" id="sco:SCO6832"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6942"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_11"/>
    <dbReference type="InParanoid" id="Q9L1V3"/>
    <dbReference type="OMA" id="LPRWNTI"/>
    <dbReference type="PhylomeDB" id="Q9L1V3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="12"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="531" mass="57859" checksum="FD2CB6F856BC8504" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1W6</accession>
    <name>Q9L1W6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6845</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630916.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031230.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6845"/>
    <dbReference type="GeneID" id="1102284"/>
    <dbReference type="KEGG" id="sco:SCO6845"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6955"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070815_0_0_11"/>
    <dbReference type="OMA" id="EWANVVE"/>
    <dbReference type="PhylomeDB" id="Q9L1W6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="206" mass="22910" checksum="43C1E789D4A03CE9" modified="2000-10-01" version="1">MTRRQCTGEYKVKPIKKKVRELLGYPYPVRIPKGVFVEQWVGISTDEFHRAKDADVKYMRNRHPLLDMSWSRADCVRYLTSLGLADTPKSSCLGCPFHGNAQWRHIRDTSPSEWANVVEFDAAIRQGNARANASGSRLLGEAFLHRSRVPLSEAPIDHVTAAERAALQPELGDADVLENGVEDGCSPWACRGDADALTQDDFGLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2I2</accession>
    <name>Q9L2I2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2501</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626741.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976301.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2501"/>
    <dbReference type="GeneID" id="1097935"/>
    <dbReference type="KEGG" id="sco:SCO2501"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2546"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_2_0_11"/>
    <dbReference type="InParanoid" id="Q9L2I2"/>
    <dbReference type="OMA" id="GVSTTWY"/>
    <dbReference type="PhylomeDB" id="Q9L2I2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="34074" checksum="C76C86F7F4207AA4" modified="2000-10-01" version="1">MTGRETAVQSPPRDTGSEIRRHELAAFLRSRRERIAPEQVGLPRGRRRRTPGLRREEVAQLSAVGVTWYTWLEQARDIQVSVQVLDALARTLLLDPTERAHLFQLAGSVDPTPATDCPAITPAVRALLEQFEPYPACVQNSRYDILAHNRTYGLLLCDLDAVPPEDRNCMVLCFTHEDWRSSIVHLEETQRLMAARFRATMAGHLAEPAWKMLLKRLRTQSPAFREAWERHEVVAHRGKRKEFLNRHVGRIRVDHTDLWLGPEPGPRMVTYAPADEDSRERLERLHAIALEREPAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCV0</accession>
    <name>Q9RCV0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0861</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB65642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625161.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027398.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0861"/>
    <dbReference type="GeneID" id="1096284"/>
    <dbReference type="KEGG" id="sco:SCO0861"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.853"/>
    <dbReference type="eggNOG" id="ENOG5032HEU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178583_0_0_11"/>
    <dbReference type="OMA" id="PHPIGER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="6854" checksum="F5A450AA394A0E72" modified="2000-05-01" version="1">MQRILPPPALCGFLVLLVLAFAASYAVGRGVGPVAPGMHGPGITQGGHGDGGTDMEEDDMGGMNHGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD82</accession>
    <name>Q9RD82_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FBP_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0795</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625096.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978065.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0795"/>
    <dbReference type="GeneID" id="1096218"/>
    <dbReference type="KEGG" id="sco:SCO0795"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.787"/>
    <dbReference type="eggNOG" id="ENOG5031HHY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116295_0_0_11"/>
    <dbReference type="OMA" id="FLHRSMC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBP_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17947" checksum="BA78DD6EC5D0E6BE" modified="2000-05-01" version="1">MRALDEQDVRTSFINCSKGEAKRLAVPRDLDERPWDDLDFLGWRDPGAPDRSYLVADLDGRPTGVALRFQPARSGYFQRSMCALCLTTHPRGGVALMTARKAGAAGREGNSVGLYMCTDLACSLYLRGRKVSQSGARFEESLTLEEQVARTLGNLSAFVAKVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP4</accession>
    <name>Q9RDP4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO2393</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626639.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2393"/>
    <dbReference type="GeneID" id="1097827"/>
    <dbReference type="KEGG" id="sco:SCO2393"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2434"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDP4"/>
    <dbReference type="OMA" id="ATWLSCK"/>
    <dbReference type="PhylomeDB" id="Q9RDP4"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB62725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="34681" checksum="5199F94A42C748BC" modified="2000-05-01" version="1">MSELFGTLSDGTPVHRWTLERAGVRVRVLSYGGIVQSAEVPDRDGHTADVVLGFADLDGYVAHPEPYFGALVGRYANRIAGGRFPLDGRTYALAPNEGPNTLHGGTRGFDKRVWDVAAVEEGVRLSRVSPHGEEGFPGRLEMSVTYTLDGSGALRIAYEAVTDAPTVLNPTNHSYFNLSGSGHAGGHELRLAASRITPVDAGLIPTGGLDDVTDTRFDFRRARKVGSGYDHNYVLDKGVTEAAEKVAELYDPASGRVLTVATTEPGLQLYTADHLGEPFAPGDGIALETQHFPDSPNRPGFPSTVLRPGEVFRSETVYGFSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP6</accession>
    <name>Q9RDP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2391</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976415.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2391"/>
    <dbReference type="GeneID" id="1097825"/>
    <dbReference type="KEGG" id="sco:SCO2391"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2432"/>
    <dbReference type="eggNOG" id="ENOG502ZWGX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114867_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDP6"/>
    <dbReference type="OMA" id="ALCPHIE"/>
    <dbReference type="PhylomeDB" id="Q9RDP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB62723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="18072" checksum="6967AAE6B6175AAF" modified="2000-05-01" version="1">MTTRGVLYVHSAPRALCPHVEWAVAGVLGTRVGLDWIRQPAAPGTWRSEFSWQGQAGIASKLASALRGWQLLRFEVTAEPSANAEGERYSCTPDLGIFHAVTGIHGDIMIPEDRLRAALVRSQRGETDLESDIAKLLGKPWDDELEPFRHAGEGAPVRWLHQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI50</accession>
    <name>Q9RI50_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0196</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37027">
        <property type="entry name" value="T37027"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624531.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026919.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0196"/>
    <dbReference type="GeneID" id="1095620"/>
    <dbReference type="KEGG" id="sco:SCO0196"/>
    <dbReference type="eggNOG" id="ENOG5031VCA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1894944_0_0_11"/>
    <dbReference type="OMA" id="TDHAGEG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="134" mass="14604" checksum="04D413277B74B125" modified="2000-05-01" version="1">MGHVHPSHLVELALGHASGEADVGALRHAASCPRCREELLRLTRVVTAARGAEASDLPVPPPERVWQRIALEVLPETDRVPRLRESSAHGSADERVRGSQRRWTDHAGEGLLGLALAIAVLLLRRWRIRAGSGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ16</accession>
    <name>COBB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="1">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobB</name>
        <name type="ordered locus">SCO1852</name>
        <name type="ORF">SCI8.37</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626120.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028009.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ16"/>
    <dbReference type="STRING" id="100226.SCO1852"/>
    <dbReference type="GeneID" id="1097286"/>
    <dbReference type="KEGG" id="sco:SCO1852"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1876"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RJ16"/>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="PhylomeDB" id="Q9RJ16"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000141270" description="Hydrogenobyrinate a,c-diamide synthase">
        <location>
            <begin position="1"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GATase cobBQ-type" evidence="1">
        <location>
            <begin position="289"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="1">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="486" mass="50069" checksum="DB9F4343780CD2B0" modified="2000-05-01" version="1">MTSSDSGSAVPRLVIAAPSSGSGKTTVATGLMAALTARGLAVSPHKVGPDYIDPGYHALATGRVGRNLDAYLCGPELVGPLFLHGARGCDIAVVEGVMGLYDGAAGEGELASTAQVAKLLRAPVVLVVDASSQSRSVAALVHGFVSWDPEVRIGGVILNKVASDRHEALLREAVDSVGVPVLGVLRRAAPVETPSRHLGLVPVAERGSDAVDAVAAMGARVADGCDLEALVGLARSTGALSCAAWDAGEALVSSPPPPLPVPSPGAAPPDPLVRPGRPRPQAPDGLRRRVAMASGAAFTFSYAEHTELLAAAGAEVVTFDPLRDEELPEGTQGLVIGGGFPEVYASELSANEGLRKSVAELAFSGAPVAAECAGLLYLCRELDGLPMCGVLDAAARMSKRLTLGYRDAVAVSDSALAVAGTRMRGHEFHRTVVEPGAGAAPAWGMRAPERRVEGFVERGVHASYLHTHWAAEPGVARRFVERCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ25</accession>
    <name>Q9RJ25_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1843</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626111.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976978.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1843"/>
    <dbReference type="ESTHER" id="strco-SCI8.28C">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.B04"/>
    <dbReference type="GeneID" id="1097277"/>
    <dbReference type="KEGG" id="sco:SCO1843"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1867"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057522_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ25"/>
    <dbReference type="OMA" id="GTTREHP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176889" evidence="1">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="158"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="375" mass="39601" checksum="9F7FC39CD9CB5EDC" modified="2000-05-01" version="1">MRTVTATAAAVTAALATGVASVAAGRLASDAALKAPPGRPLPTEPRLTVHGTAAGQITLTRHLAALRPGRYGLAGDGSHAVLGPVLDTAEHGADTVVRRLERVTHGTLATGDRAWFTPNLYVGNPGTALDLEYADVEVPGELGPLPAWFLPGARPTWIVAVHGLAATREHALNLIAPLHRRNVPVLALAYRGDVGAPPSPDGLHHFGETEWRDVDAAVRYALDHGARQVVLLGWSTGATMALRTAALSGVRERIAGLVLDSPVLSWETTLRALAAARRTPGALLPLAVRAAQGRAGLHADRDTGTAGLHRPAVPTLIFHGPGDEVAPWRLSRRLADTHPRLVALHTVRDAPHGAMWNADPADYEETLRRFMTPLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ47</accession>
    <name>MOAA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="1">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaA</name>
        <name type="ordered locus">SCO1821</name>
        <name type="ORF">SCI8.06c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626089.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977001.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ47"/>
    <dbReference type="SMR" id="Q9RJ47"/>
    <dbReference type="STRING" id="100226.SCO1821"/>
    <dbReference type="PRIDE" id="Q9RJ47"/>
    <dbReference type="GeneID" id="1097255"/>
    <dbReference type="KEGG" id="sco:SCO1821"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1843"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RJ47"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="PhylomeDB" id="Q9RJ47"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="chain" id="PRO_0000153002" description="GTP 3',8-cyclase">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="341" mass="37503" checksum="3E829DD38F2CDB7E" modified="2000-05-01" version="1">MLRRSASREGAHVLIDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIDIAVTSLGIEEVRFTGGEPLLRPGLVGIVERVAALEPRPQMSLTTNGIGLRRTATALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHKDVLEGLAAAREAGLTPVKVNSVLMPGLNDDEAPDLLAWAVEHDYELRFIEQMPLDAQHGWKREGMVTAGDILTSLRTRFELTAEGSEERGSAPAERWLVDGGPHRVGVIASVTRPFCSACDRTRLTADGQVRTCLFATEETDLRAALRSDAPDEEIARIWRLAMWGKKAGAGLDDPTFVQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ75</accession>
    <name>Q9RJ75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1626</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027891.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1626"/>
    <dbReference type="GeneID" id="1097057"/>
    <dbReference type="KEGG" id="sco:SCO1626"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1641"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_2_11"/>
    <dbReference type="InParanoid" id="Q9RJ75"/>
    <dbReference type="OMA" id="HECPGQD"/>
    <dbReference type="PhylomeDB" id="Q9RJ75"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="498" mass="55159" checksum="B92C32F4739A8508" modified="2000-05-01" version="1">MTPESHSPTGTGEPLLEPPPGCPAHGLGPGGLHRLHEAEDLEELYEKLREQHGPVAPALLHDDVPMWVVLGHAENLHMVSTPSQFCRDSRIWTPLNEGMVKPDHPLMPHIAWQPICSHAEGDEHKRLRGAVTSAMSDLDYRELRRHIKRYTQRVVNRFCEEGRADLVSQFAEHLPMGVMCHLLGMPEEYNDRLVEAARDTLKGTETAIASHAYVMEALGRLTATRRADPADDIAGRLVTHPAGLTDDEVREHLRVVLLAAYEATVNLIGNVMRVVLTDPGFRAQLSGGQMTVPQAVEQSLWDEPPFSTVFAYFAKQETELGGQRIRAGDGLLLGIAPGNVDPRIRPDLDASMMGNRAHLAFGGGPHECPGQDIGRAIADAGIDALLMRLPDLQLDCDEDDLRWRSSIASRHLVELPVRFEPRAQQDIMQQPSHAPTPERHAPWHVGLPKPERRAQPPLPAQPPQPVSVTAAEPQQAPGAGQPRPRGAWQRFLLWWRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ99</accession>
    <name>Q9RJ99_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0665</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624974.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027280.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0665"/>
    <dbReference type="GeneID" id="1096088"/>
    <dbReference type="KEGG" id="sco:SCO0665"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.649"/>
    <dbReference type="eggNOG" id="ENOG5031XUN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2669561_0_0_11"/>
    <dbReference type="OMA" id="MRESSWS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176895" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="75" mass="7336" checksum="42BF165B1CA3A08E" modified="2000-05-01" version="1">MRKSSCTVVAALTLSVLGATGAEASAPRAPSVASDVTASECLRGGGVIIISADGDGTGTFTKLCRGGIHDGQTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJD8</accession>
    <name>Q9RJD8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625057.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027332.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0754"/>
    <dbReference type="GeneID" id="1096177"/>
    <dbReference type="KEGG" id="sco:SCO0754"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.745"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028453_0_1_11"/>
    <dbReference type="OMA" id="PLYATVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004332065" evidence="1">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="25442" checksum="A63741663868A366" modified="2000-05-01" version="1">MRFARPQGWLVLSVTLIAMAAASVWAVGGSVTSTVSAPAVLTHGQGSYLLQSPVSGQVTAVLARPGQRLAADAPVLKVRTAKGETVVRTVDAGRVSALAATVGQIIATGANVASVEKVAHAGDPLYATVYVPAENAAAIPAHASVDLTVQSVPTQQYGVLHGEVKSVDRSAQSAQTIGAFLGDSALGEQFTEDGRPVAVTVRLATSKSTKSGYAWSSADGPPFELTSMTLASGSIRLADQRPVDWLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK0</accession>
    <name>Q9RJK0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624710.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0388"/>
    <dbReference type="GeneID" id="1095811"/>
    <dbReference type="KEGG" id="sco:SCO0388"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.364"/>
    <dbReference type="eggNOG" id="COG5360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022012_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RJK0"/>
    <dbReference type="OMA" id="WCAEHDG"/>
    <dbReference type="PhylomeDB" id="Q9RJK0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="128"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="653" mass="71113" checksum="86660056E9E599CB" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK7</accession>
    <name>Q9RJK7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0381</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624703.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978484.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0381"/>
    <dbReference type="GeneID" id="1095804"/>
    <dbReference type="KEGG" id="sco:SCO0381"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.357"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_2_11"/>
    <dbReference type="InParanoid" id="Q9RJK7"/>
    <dbReference type="OMA" id="AYGPDIR"/>
    <dbReference type="PhylomeDB" id="Q9RJK7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="298"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="491" mass="53904" checksum="021F221343D5BF17" modified="2000-05-01" version="1">MRQGGLVSAFPSARGQLADGATSRLTSDWEQRYRRTVITSDTVTTAVVVAGIGNFFGVRDAANWHEKWGILAFGTWLLVLGALAVSRSWSPAVLGQGAEEFRRLGRSLFMATVVLALGGIALTSRNIKLWIFVAVPAIAIFIMVARYALRVRLHRQRKQGRCLRPVLAAGSPATVRDLIARTRRFPHLGWRVDAVCTTDDGLEGGQLDGVPVVGPLEHVAHHVRRDGYRVVAVTPDPHWSPHRLQRLAWNLEGSDAEMVVAPVLMEVAGPRLHVDAVLGIPLLRVSMPTFTGGRRAVKAVVDRLGAAVLLTLFAPLMLFVALLVLVDSRGGAFYRQRRVGKDGREFTILKFRTMVAGADGARAALADRNEGAGLLFKLRRDPRVTRVGAVLRRYSVDELPQLLNVLAGSMSLVGPRPPLPEESAAYGPDIRRRLLVKPGLTGLWQISGRSDLPWEEAVRLDLRYVEDWSLALDTVILWKTLRAVVHGQGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJN3</accession>
    <name>Q9RJN3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0611</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027245.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0611"/>
    <dbReference type="GeneID" id="1096034"/>
    <dbReference type="KEGG" id="sco:SCO0611"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.593"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_9_0_11"/>
    <dbReference type="OMA" id="TFAATWL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="25134" checksum="12444C5B3E221FDB" modified="2000-05-01" version="1">MAGASVPVLVALGLLGLVGGVGITAVGPGGVLPTIGLFALTGLTPAQVAGTALVTHVATGMLATAAYTRSGQLREPGTRRTALVLAVSAVAGTPLGVLVNSYVSKRMFGLVLGVFVAGVAGLVWFREHRRPAGSRAHPPTAVVAGTGCAVAVAAGVVGIGGPMLTVPLLVALGVPVLESLASAQAQSVVIAGVGTVGYLAQGAVDWPLAVLVGVPELAGVLLGWRIAHALPTRHLKYALITTLLALAPYLALHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ5</accession>
    <name>Q9RJQ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0585</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624897.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0585"/>
    <dbReference type="GeneID" id="1096008"/>
    <dbReference type="KEGG" id="sco:SCO0585"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.566"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJQ5"/>
    <dbReference type="OMA" id="ISLNDRM"/>
    <dbReference type="PhylomeDB" id="Q9RJQ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="19806" checksum="B5F6B9E6367D702D" modified="2000-05-01" version="1">MGGFGVGKTTLVRSVSEIRPLNTEEVMTQAGVGVDETGGVTSKTTTTVAFDFGRISLNDRMVLYLFGAPGQERFWFLWDRLFSGTLGAVVLVDTRRMDDSWYAIDRLEHHRTPFVVAVNRFDDDTARHSLDEIRLALALPDHVPLIDCDARVRTSGKHVLVTLVDHLYQLALAQESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJU4</accession>
    <name>Q9RJU4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0366</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624689.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027056.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0366"/>
    <dbReference type="GeneID" id="1095789"/>
    <dbReference type="KEGG" id="sco:SCO0366"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.342"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056939_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJU4"/>
    <dbReference type="OMA" id="GYEWTGH"/>
    <dbReference type="PhylomeDB" id="Q9RJU4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027839">
        <property type="entry name" value="DUF4432"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14486">
        <property type="entry name" value="DUF4432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB55728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="39619" checksum="BEE679226DC0E257" modified="2000-05-01" version="1">MKLYGRSHDRQSLARHAGDLSAAGGVRAVVLDDGSERGIRTLEFRTGGGLSFDVLVDRAMDLGGAEFEGRGFGWRSATGFRHPGLHEYRDDDGLSMMRSFSGLLLTAGLDHTLFGAEVDASQYRYPPRGTAVHALHGRVANLPARLTGYGERWQEDGRCVLWAEGEVRQAAIFGEHLRLTRRIEADLGGSEIRLTDRVRNAGFDPTPHMYLYHVNVGWPFLDEGARYELPPHRTLWRSDSVAEQGVSHTAMPAPLPGFVEQVYEHELEPDAAGLARPRLVNERLGVYFELEFDTVRFPSFFQWLHLREGAYAVGFEPSTHHVQGEAAAREDGSMTFLAPGEEREYTTAFRVGHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJW2</accession>
    <name>Q9RJW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible 2-hydroxyacid-family dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0348</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624671.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027040.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0348"/>
    <dbReference type="GeneID" id="1095771"/>
    <dbReference type="KEGG" id="sco:SCO0348"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.323"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_11"/>
    <dbReference type="InParanoid" id="Q9RJW2"/>
    <dbReference type="OMA" id="RGEWQVS"/>
    <dbReference type="PhylomeDB" id="Q9RJW2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="120"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="35899" checksum="661E6741902274CD" modified="2000-05-01" version="1">MTRPRAVLAMNPRLVHAVFDEAALARLRRAADIDTGQVLAELDSARSRDALAGAEILVAGWDAPVVRAEHLPGTERLRAVVYAGGVAATCLEDPAAFAARGVVAANARAANSGPVAEYTLAMILLANKRVLAEERRYRASRTLPDHFGAYAGRGNYRQTVGIVGASTVGRAVLGLLRPFDLDVLLYDPTLTAEQAAALGARLVPLDELMAHSRVVSLHQPLTPATRGQIDAGRLALMPDGATLVNTARGAVVDQDALLAEVRTGRIDAVLDVTEPEPPDPGSELWALDNVVLTPHLAGSLGGELHRIGDAVADEVERFATGRPFAHPEDLAASARTRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK19</accession>
    <name>Q9RK19_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0487</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36405">
        <property type="entry name" value="T36405"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624804.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027152.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0487"/>
    <dbReference type="GeneID" id="1095910"/>
    <dbReference type="KEGG" id="sco:SCO0487"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.467"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="InParanoid" id="Q9RK19"/>
    <dbReference type="OMA" id="RMQVVGP"/>
    <dbReference type="PhylomeDB" id="Q9RK19"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="18372" checksum="A84FD12DBA38F342" modified="2000-05-01" version="1">MTPEAAEPAGPDDPHDDLLTVLPRLTQLSAAFNKGRLTERAAEAAGLALDRPAMGVLVTLRAADQPLRIGEIADRMQVVGPHVTRQVQALEKRGLVRRVADPHDRRASLIEPTGDGLDAANRYMTSLLGWFAEALADWPPQDREDLTRLLTRLADDVTARLARLDAED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKC6</accession>
    <name>Y3161_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative ABC transporter ATP-binding protein SCO3161</fullName>
            <ecNumber>7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3161</name>
        <name type="ORF">SCE87.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627377.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028802.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKC6"/>
    <dbReference type="SMR" id="Q9RKC6"/>
    <dbReference type="STRING" id="100226.SCO3161"/>
    <dbReference type="GeneID" id="1098595"/>
    <dbReference type="KEGG" id="sco:SCO3161"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3221"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9RKC6"/>
    <dbReference type="OMA" id="YALELCP"/>
    <dbReference type="PhylomeDB" id="Q9RKC6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092093" description="Putative ABC transporter ATP-binding protein SCO3161">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="16"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="260" mass="27474" checksum="E04B18E4930E8C54" modified="2000-05-01" version="1">MTGPAAAPVPDAPASLDVSGLAFAYPDGHQALFGVDFCVARGERVALLGPNGAGKTTLVLHLNGILTGGTGTVTVAGLPVDKRNMAEIRRRVGIVFQDPDDQLFMPTVREDVAFGPAAAGVKGAELEACVDRALTLVGMAEFKDRPPHHLSFGQRRRVAVATVLAMEPEILVLDEPSSNLDPASRRELADILRSLDVTVLMVTHDLPYALELCPRALILSDGAIAADGPTAALLSDDDLMRAHRLELPFGFDPRSVRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKU2</accession>
    <name>Q9RKU2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6250</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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    </feature>
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            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="19591" checksum="587B67C655F31E0F" modified="2000-05-01" version="1">MRRRIVCQTAATAGPSPRPSSVATAVVSLALSPRLNLRFGSRNVLLAGLLLIAGALVLAGRAPVEAEYWIDVLPMMVLLGGGAGLSMPAVMTLAMSGATPQDAGLVSALAGTTGMVGGSLGLAVWTALAAGRTTDLLADGRAPLEALNGGFHYVFYLSAGVVVVSAVVAFLMLCTPVAPAGPLPAPATTDEPAASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKW2</accession>
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    </protein>
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    <organism evidence="10">
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            <taxon>Streptomycetaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO6214"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6328"/>
    <dbReference type="eggNOG" id="COG2233">
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    <dbReference type="HOGENOM" id="CLU_017959_8_2_11"/>
    <dbReference type="InParanoid" id="Q9RKW2"/>
    <dbReference type="OMA" id="MCSAFAQ"/>
    <dbReference type="PhylomeDB" id="Q9RKW2"/>
    <dbReference type="Proteomes" id="UP000001973">
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="project" value="GO_Central"/>
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    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
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            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
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        <location>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="186"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="215"/>
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            <end position="254"/>
        </location>
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            <end position="366"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="429"/>
        </location>
    </feature>
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            <begin position="439"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB61316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="462" mass="47478" checksum="C26DC21E9E19FC3D" modified="2000-05-01" version="1">MADHPVDEKLPPLKMATTGLQHVAAMYAGVVAPPLIVGAAIGLSATELTFLTGACLFTAGLATFLQTLGIWKIGARLPFVNGVTFAGVAPMTAVVASTDDKSDALPIIFGAVIVAGLLGFVAAPFFSKAIRFFPPVVTGTVITLIGISLLPVAFGWAQGPSPTADDFGSATNLGLAGITLAIVLFLRRFTRGFVKQIAVLLGLVAGTLVAIPFGVTDFGPVADADVVGFPTPFHFGAPQFQIAAIISMCVVMVVSMTESTADMLALGEIVDRPADEKTIAAGLRADTLGSALSPVFNGFMCSAFAQNIGLVAMTKIRSRYVVAVGGGFLVLMGLCPMAASLIAVVPRPVLGGAGVVLFGSVAASGIQTLVRASLDKDNNVLIVAVSLAVGIIPIAAPEFYHSFPENARIILDSGISTGCVAAVLLNLVFNHIGGRGRDAEDVTHPMEAGDEITESSREAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1P6</accession>
    <name>Q9S1P6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO0245</name>
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    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37160">
        <property type="entry name" value="T37160"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624577.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026954.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0245"/>
    <dbReference type="GeneID" id="1095669"/>
    <dbReference type="KEGG" id="sco:SCO0245"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.217"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="InParanoid" id="Q9S1P6"/>
    <dbReference type="OMA" id="KPAVHHW"/>
    <dbReference type="PhylomeDB" id="Q9S1P6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="283"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="36090" checksum="4BD2885FB47591B8" modified="2000-05-01" version="1">MSFPLALFVTVLLLVGSGFFVAAEFALVAAKRHRMEKAVADGQRGAKAALAGMRELSLMLAGAQLGITVCTLGLGSVSKPAISHELDPLLHELGLPAALSYGVAFALAMIVVVFLHMVLGEMAPKSWAIAHPERSAMLLAPPFRAVTTAVRPLIRVLNRISNALVRLCRVAPRDELASVHNRDQLTHLVEESERLGLISETDSDLLTRSLTEPETPVRDLMAPAAGIVAVDAGAEAEEILALAAAHDRTRLLVRQEDAILGSVHARDVLVARAQGRATGARALARPVPELAEDATVAEAIEVLRRRRASLAVVRDGAGRLTGIVSLDDLLARYLQPQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2D3</accession>
    <name>Q9S2D3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0280</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB54165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36468">
        <property type="entry name" value="T36468"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624609.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026985.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0280"/>
    <dbReference type="GeneID" id="1095704"/>
    <dbReference type="KEGG" id="sco:SCO0280"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.254"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_6_0_11"/>
    <dbReference type="InParanoid" id="Q9S2D3"/>
    <dbReference type="OMA" id="TIIALQW"/>
    <dbReference type="PhylomeDB" id="Q9S2D3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00052">
        <property type="entry name" value="TIGR00052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB54165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25503" checksum="9C426F8CA35F51E5" modified="2000-05-01" version="1">MKARPGVDAPDHRGRTGLDRAGRELDRNPGVVVRDVELTSQGWHVLRRTTFDYRRRDGRWETQARETYDRGNGAVVLPYDTGRGRVLLTRQFRYPAYVNDHPDGMLVEAAAGLLDADDAPAAVRREAAEELGVALGPLTHVLDAYMSPGSVTERLHFFAAPYTPADRTGTGGGVEEEGEDIEVLEMPFTEALAMTRDGRIADGKTILLLQWAALHGPFAPHPADMADADNTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2V7</accession>
    <name>Q9S2V7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34969">
        <property type="entry name" value="T34969"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626358.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028139.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2099"/>
    <dbReference type="GeneID" id="1097533"/>
    <dbReference type="KEGG" id="sco:SCO2099"/>
    <dbReference type="HOGENOM" id="CLU_1659781_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="17181" checksum="D950A20F2267097B" modified="2000-05-01" version="1">MTGVGTAGPLGALARWVRVGAGLGQDRLEDQHPLHQAQEHRHVAYQVVGVPAARRAPDARLGARPARRAGGEQRAPLGQLGRDLGQHLPGAADAGPGPWAGLRAAARGQHRGGGAQGGEVGRRVALVRRFEGGGLLQPGPGLGEQVEGGGRGGRPAEHGVHVARRSGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-27" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2W4</accession>
    <name>RSMH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">SCO2092</name>
        <name type="ORF">SC4A10.25c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34962">
        <property type="entry name" value="T34962"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2W4"/>
    <dbReference type="SMR" id="Q9S2W4"/>
    <dbReference type="STRING" id="100226.SCO2092"/>
    <dbReference type="GeneID" id="1097526"/>
    <dbReference type="KEGG" id="sco:SCO2092"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2125"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2W4"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="PhylomeDB" id="Q9S2W4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000108717" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="310" mass="33654" checksum="91851BF0D843BF80" modified="2000-05-01" version="1">MMLQRCLDLLAPALQEPGAVVVDCTLGLGGHSEALLERFPEARLVALDRDKEALRLSGERLAPYGGRATLVHAVYDELPDVLDRLGVPRVQGVLFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQSTGMSAAEVLNTYPPGELVRILRAYGEEKQAKRIVSAVVREREKEPFTNSARLVELIRAALPQAAKRTGGNPAKRTFQALRIEVNGELSVLERAIPAAVESVAVGGRIAVLSYHSLEDRLVKQVFAAGAANTAPPGLPVVPEQYAPRLKLLTRGAELPTEEEIAENRRAAPARLRGAERIRESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7W4</accession>
    <name>Q9X7W4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6769</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35409">
        <property type="entry name" value="T35409"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630841.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031169.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X7W4"/>
    <dbReference type="STRING" id="100226.SCO6769"/>
    <dbReference type="GeneID" id="1102208"/>
    <dbReference type="KEGG" id="sco:SCO6769"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6878"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="InParanoid" id="Q9X7W4"/>
    <dbReference type="OMA" id="VYSSMDR"/>
    <dbReference type="PhylomeDB" id="Q9X7W4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="461" mass="50544" checksum="97A1DDDB5BA4393E" modified="1999-11-01" version="1">MTKEFDLAALLAERGAERYELHARHLNHQLPRMLHTIGFDKVYERAEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVLDASLADLTRFDCPPLPGLLAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRILYCPHAFHGLTAGSLSVNGEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVEPVQGKGVHEAPPGYLLAAQELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVCVAKALSGGYVPVGATLGKDWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENEEIVANAAAVGERLKSRLAELVDRYELLADVRGRGLMIGIEFGRPRSLKLRSRWTMLQAARKGLFAQMVVVPLLQRHRILTQVSGDHLEVIKLIPPLIVDTDDADRFVDAFTEVMEDAHHGGGLMWDFGKTLVKQAVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X829</accession>
    <name>Q9X829_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6062</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35854">
        <property type="entry name" value="T35854"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630171.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030626.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6062"/>
    <dbReference type="GeneID" id="1101503"/>
    <dbReference type="KEGG" id="sco:SCO6062"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6163"/>
    <dbReference type="eggNOG" id="COG1125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_2_2_11"/>
    <dbReference type="InParanoid" id="Q9X829"/>
    <dbReference type="OMA" id="AKRYPYQ"/>
    <dbReference type="PhylomeDB" id="Q9X829"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB41555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="386" mass="40841" checksum="81E8396370DAF83E" modified="1999-11-01" version="1">MDSVTKRYPDGTVAVDRLSLEIPDRAITVLVGPSGCGKTTTLRMINRMVEPTEGTILLDGEDLQQQPVTTLRRSMGYVIQNAGLFQHRTILDNIATVPRMIGWGKQKSRERAAELMERVGLDASLAKRYPYQLSGGQQQRVGVARALAADPPVLLMDEPFSAVDPVVRKGLQDELLRIQDELGKTIVFVTHDIDEAIKLGTMVAVMRTGGRLAQFAPPAELLSDPADDFVEDFLGADRGIRRLSFFPSAGLELTTGPVVRADATAEQLAAAGGAPHLLVTDADDRPLGWAEPGDLTAGDLAAGRLLSFGRPFVPGTDSLRAALDCAVLSPTGWAVAVDADGRVTGVVSQQTVGAAIRSAHGAGDPGAVTPGDARAEEPGDVTKVAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X844</accession>
    <accession>Q9X8N9</accession>
    <name>PANC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate synthetase</fullName>
            <shortName evidence="1">PS</shortName>
            <ecNumber evidence="1">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panC</name>
        <name type="ordered locus">SCO3383</name>
        <name type="ORF">SCE126.01c</name>
        <name type="ORF">SCE94.34c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAD55315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733602.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975450.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X844"/>
    <dbReference type="SMR" id="Q9X844"/>
    <dbReference type="STRING" id="100226.SCO3383"/>
    <dbReference type="GeneID" id="1098820"/>
    <dbReference type="KEGG" id="sco:SCO3383"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3446"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_0_2_11"/>
    <dbReference type="InParanoid" id="Q9X844"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="PhylomeDB" id="Q9X844"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000128278" description="Pantothenate synthetase">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>beta-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <sequence length="337" mass="35456" checksum="3C948F7014A2913C" modified="2000-05-30" version="2">MTTPTPPVLLRTAGELHARVRRGRRAVVMTMGALHEGHATLIRTARDIAGPDGEVVVTVFVNPLQFGAGEDLDRYPRTLDADLEIAGRAGADAVFAPAVDEVYPGGEPQVRVTAGPMGGRLEGASRPGHFDGMLTVVAKLLHLTRPDLALYGQKDAQQLALIRRMVRDLNFGVEIVGVPTVREEDGLALSSRNRYLSTAERRTALALSQALFAGLDRHAAQEALCARAREVPATQARAEALSALGESRAAADAHAVATSAPGSATAVRDAARLVLDDAARATPPLELDYLALVDPSDFTEIGDDHTGEAVLAVAARVGATRLIDNVHLTFGPLGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8L5</accession>
    <name>Q9X8L5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="8" type="ordered locus">SCO3351</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36362">
        <property type="entry name" value="T36362"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627559.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028928.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3351"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="GeneID" id="1098788"/>
    <dbReference type="KEGG" id="sco:SCO3351"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3414"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_11"/>
    <dbReference type="InParanoid" id="Q9X8L5"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="PhylomeDB" id="Q9X8L5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="69"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="355"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB40851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="469" mass="49839" checksum="62A6102AC2A40BDD" modified="1999-11-01" version="1">MAARTKSAKERPSYRCTECGWQTAKWLGRCPECQAWGTVEEYGAPAVRTTTPGRVTTSAVPIGQVDGRQATARSTGVPELDRVLGGGLVPGAVVLVAGEPGVGKSTLLLDVAAKSASDEHRTLYVTGEESASQVRLRADRIHAIDDHLYLAAETDLAAVLGHLDAVKPSLLILDSVQTVASPEIDGAPGGMAQVREVAGALIRASKERGMSTLLVGHVTKDGAIAGPRLLEHLVDVVLHFEGDRHARLRLVRGVKNRYGTTDEVGCFELHDEGITGLADPSGLFLTRRAEPVPGTCLTVTLEGRRPLVAEVQALTVDSQIPSPRRTTSGLETSRVSMMLAVLEQRGRISALGKRDIYSATVGGVKLSEPAADLAVALALASAASDTPLPKNLVAIGEVGLAGEVRRVTGVQRRLSEAHRLGFTHALVPADPGRVPDGMKVLEVADMGDALRVLPRSRRREATREEEDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X927</accession>
    <name>Q9X927_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3562</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36683">
        <property type="entry name" value="T36683"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627760.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029087.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3562"/>
    <dbReference type="GeneID" id="1098998"/>
    <dbReference type="KEGG" id="sco:SCO3562"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3618"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_11_0_11"/>
    <dbReference type="InParanoid" id="Q9X927"/>
    <dbReference type="OMA" id="GCWFRVT"/>
    <dbReference type="PhylomeDB" id="Q9X927"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015138">
        <property type="term" value="F:fumarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015741">
        <property type="term" value="P:fumarate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071422">
        <property type="term" value="P:succinate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="9">
        <location>
            <begin position="36"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB38499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="830" mass="85654" checksum="9CBF85DF79578B95" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI4</accession>
    <name>RECR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">SCO3618</name>
        <name type="ORF">SC66T3.29c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-08" db="EMBL/GenBank/DDBJ databases">
            <title>Nucleotide sequence analysis and genetic characterization of the recR gene of Streptomyces.</title>
            <authorList>
                <person name="Pelaez A.I."/>
                <person name="Ribas-Aparicio R.M."/>
                <person name="Gomez A."/>
                <person name="Rodicio M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="AF151381">
        <property type="protein sequence ID" value="AAD34032.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35386">
        <property type="entry name" value="T35386"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627813.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975321.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAI4"/>
    <dbReference type="SMR" id="Q9XAI4"/>
    <dbReference type="STRING" id="100226.SCO3618"/>
    <dbReference type="GeneID" id="1099054"/>
    <dbReference type="KEGG" id="sco:SCO3618"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3676"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAI4"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="PhylomeDB" id="Q9XAI4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000190396" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="199" mass="21795" checksum="4456F370CFD8EE90" modified="1999-11-01" version="1">MYEGVVQDLIDELGRLPGVGPKSAQRIAFHILQAEPVDVRRLAQALMEVKAKVRFCATCGNVAQEEQCNICRDTRRDPSVICVVEEPKDVVAIERTREFRGRYHVLGGAISPIDGVGPDDLRIRELLARLADGSVTELILATDPNLEGEATATYLARMIKPMGLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAP6</accession>
    <name>Q9XAP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative bi-functional transferase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4554</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34632">
        <property type="entry name" value="T34632"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974391.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4554"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1099994"/>
    <dbReference type="KEGG" id="sco:SCO4554"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4626"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012505_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAP6"/>
    <dbReference type="OMA" id="GTMQALW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="102"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="743" mass="81310" checksum="002CCBCDFEB330C4" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y2</accession>
    <name>Q9Z4Y2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3249</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36197">
        <property type="entry name" value="T36197"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627461.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028857.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3249"/>
    <dbReference type="GeneID" id="1098683"/>
    <dbReference type="KEGG" id="sco:SCO3249"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3313"/>
    <dbReference type="eggNOG" id="ENOG5031XWD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2572255_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="8414" checksum="F3DDC811E1917D1A" modified="1999-05-01" version="1">MSTDPKSVVHGILAEDLEVDPAEITDGASLRNLELDSLAVAELIVRIKEETGVDLSGDETRIADLTVGEVVLLAGSGLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y9</accession>
    <name>Q9Z4Y9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Puitative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3242</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36190">
        <property type="entry name" value="T36190"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627454.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028852.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3242"/>
    <dbReference type="GeneID" id="1098676"/>
    <dbReference type="KEGG" id="sco:SCO3242"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3306"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060108_1_0_11"/>
    <dbReference type="InParanoid" id="Q9Z4Y9"/>
    <dbReference type="OMA" id="VWTYDLV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="28876" checksum="7349A2B79E128946" modified="1999-05-01" version="1">MSALPRVHDLARLVRAPAALSVPGDVLAGAAAARRPLGPGLLGMTASSVCLYWAGMALNDYADRDLDAVERPERPVPSGAVSPAAARAVGCGLTAAGLGLAALSRGRRGLATALPLAGVVWAYDLVLKPTPAGAAAMAAARALNVLGGAGPGGLRRALPAAATVALHTGMVTRLSRYEVSGAPRAVPRQSLAVGGAVGAAVLLRGRRRPARDRVLAAGLTAVYAYGGAAAQLAAARSPAAPQVRRAVAAGIHALIPLQAALTATAGRGAAGAALACALPWARRLGRKVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Z8</accession>
    <name>Q9Z4Z8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3233</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36181">
        <property type="entry name" value="T36181"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627445.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975579.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3233"/>
    <dbReference type="ESTHER" id="strco-SCE29.02">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1098667"/>
    <dbReference type="KEGG" id="sco:SCO3233"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3297"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_11"/>
    <dbReference type="InParanoid" id="Q9Z4Z8"/>
    <dbReference type="OMA" id="DWIDMFT"/>
    <dbReference type="PhylomeDB" id="Q9Z4Z8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="29478" checksum="AE00EB4654A0D3A7" modified="1999-05-01" version="1">MPVLTVNGIRINYYDDAPPAGAQNAPAVLLVMGSGGSGRAWHLHQVPALVAAGFRVISFDNRGIAPSEECPGGFGIDDLVADTAALVEELRLGPCRVAGISMGAHIAQELALSRPDLVDRLVLMATRARPDALREALCRAEMELYDQGIRLPAAYEAVVQAMQNLSPRTLDNDVQARDWLDVLELTRRSGAGYRAQLGVRVDGDRREAYRGIRAATRVVAFQDDLIAPPHLGREVADAIPGAEYELVPDCGHYGYLESPDAVNKSLVEFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z542</accession>
    <name>Q9Z542_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6130</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35913">
        <property type="entry name" value="T35913"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630236.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6130"/>
    <dbReference type="GeneID" id="1101571"/>
    <dbReference type="KEGG" id="sco:SCO6130"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6234"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_4_4_11"/>
    <dbReference type="InParanoid" id="Q9Z542"/>
    <dbReference type="OMA" id="PGKIVWC"/>
    <dbReference type="PhylomeDB" id="Q9Z542"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="12285" checksum="B3FFD812AE2809D3" modified="1999-05-01" version="1">MPAARAFAREALADWGVRGRADDVVLCVSELATNALLHGVPPGRGFLLRLWLLPCGDGVRVEVHDSGDGVPAVPLESGGSDEGGRGLLLVSELADKWGVAEREPGKVVWFECGVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5C0</accession>
    <name>Q9Z5C0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6182</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34836">
        <property type="entry name" value="T34836"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630285.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030718.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6182"/>
    <dbReference type="GeneID" id="1101623"/>
    <dbReference type="KEGG" id="sco:SCO6182"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6292"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085077_2_2_11"/>
    <dbReference type="InParanoid" id="Q9Z5C0"/>
    <dbReference type="OMA" id="EHQICLE"/>
    <dbReference type="PhylomeDB" id="Q9Z5C0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB36590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="29186" checksum="9A72A37FE3339861" modified="1999-05-01" version="1">MNPADSPVKAVLFDRDGTLVHDVPYNGDPERVRPVEGAREAVALLRAHGIRVGVVTNQSGVARGLISDGDVRRVNRRIDDLIGPFDVWAVCPHGPDDGCHCRKPRPGLILWAAGRVCAAPADCVVIGDIGADTEAAERAGAHGILVPNDRTRPAETAAAAHVAPDLLTAVRALVTGPPRGRVPADERPVEAAYGTDPASTGPRTAAAQDDDRPGPAGTPFATAPGPGAFRPGDAAHRPPPEPRPGGAGTPAGNGADTAEPARTRAVPDAGAVRGPGVGHRRGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBU6</accession>
    <name>Q9ZBU6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6142</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34655">
        <property type="entry name" value="T34655"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630247.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6142"/>
    <dbReference type="GeneID" id="1101583"/>
    <dbReference type="KEGG" id="sco:SCO6142"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6246"/>
    <dbReference type="eggNOG" id="ENOG5032VWP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694563_0_0_11"/>
    <dbReference type="OMA" id="PHKAIRR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA22376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="18076" checksum="7B7D4438ECFB3B90" modified="1999-05-01" version="1">MRDMNDTRTPTSTVTSTRTPADAVTGMVDHVLHLAAGWTRWDGTPAHVDGRVYTPHKAIRRVADHLVDHLAELEARLAGEETQPDHWHASLVTTEADRAAFTAEDLDEARSRLTRLARIWANRLDALTDEQLDHSPGEGWSFRELAAHLAESGYYADAVGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBW2</accession>
    <name>Q9ZBW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6556</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34998">
        <property type="entry name" value="T34998"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972424.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101995"/>
    <dbReference type="KEGG" id="sco:SCO6556"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6660"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039013_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBW2"/>
    <dbReference type="OMA" id="FFFYGLK"/>
    <dbReference type="PhylomeDB" id="Q9ZBW2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026166">
        <property type="entry name" value="UCP026166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="345" mass="36332" checksum="E06C0D508C123FC9" modified="1999-05-01" version="1">MKRLRWPRWMPIDPYILLLLGTVGLAALLPARGTGADVASGASTGAIAFLFFLYGARLSTREAMDGVRHWRLHVTVLACTFVVFPLLGLASRGLVPVFLTDPLYQGLLFLTLVPSTIQSSIAFTSIARGNVPAAICAGSFSSLVGIVVTPLLAAALLGGGGGGFSADSVVKIVLQLLVPFLAGQLLRRWIGGFVARHKKVLGLVDRGSILLVVYTAFSEGMVEGIWHQVSPARLAGLLAVQAVLLAVMLALTWYGAKGLGFGREDRIAIQFAGSKKSLAAGLPMASVLFGAQASLAVLPLMLFHQMQLMVCAVIAKRRSRDPEAVASEESAARVRTAVGTGSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O54167</accession>
    <name>O54167_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5938</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35703">
        <property type="entry name" value="T35703"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030547.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5938"/>
    <dbReference type="GeneID" id="1101380"/>
    <dbReference type="KEGG" id="sco:SCO5938"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6034"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091682_0_0_11"/>
    <dbReference type="InParanoid" id="O54167"/>
    <dbReference type="OMA" id="PDCANLG"/>
    <dbReference type="PhylomeDB" id="O54167"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="202" mass="22213" checksum="F5178358EA702349" modified="1998-06-01" version="1">MLTWVRITKYVHSCVRLEHEGGTLVIDPGVWSESEALAGADAVLVTHEHNDHVDLLRLRGLDVPVYAPKSARLPGLDFNGVVAGEEFTAAGFRVPPRGGRHARIYGDRPDCANLGYLVDDRLYHPGDSLHLPDRPVETLLVPLQGSWMKTDEAIDFVRAADPERAFGIHDGQVNERGLSSLNGWLTDECGGRYRWLAPGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O69962</accession>
    <name>O69962_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5786</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35106">
        <property type="entry name" value="T35106"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629910.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030452.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5786"/>
    <dbReference type="CAZy" id="CBM2">
        <property type="family name" value="Carbohydrate-Binding Module Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1101228"/>
    <dbReference type="KEGG" id="sco:SCO5786"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5876"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717509_0_0_11"/>
    <dbReference type="InParanoid" id="O69962"/>
    <dbReference type="OMA" id="NGALQWN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174856" evidence="2">
        <location>
            <begin position="38"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA18323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="400" mass="41399" checksum="76A5A587F5404EB8" modified="1998-08-01" version="1">MRTRVLRLLRRPWTAAVAAVALVVSVLVAMPASGAAAAACRVDYGVDAWAGGYTARVRITNLGPAVSDWRLTWTYTGDQQVTSAWNATVTQTGASVVAVDAGWNGAVSTGGTAEFGLQGTWRSADPAPDDFALNGTSCGDGGTPTATPTTSPTAPPTTPPTTPPPTTPPPAAECGDAVICSGFEDQAGPEPSGDWRFTAPDCQGTGTAAVDSAVSHAGGRSLRVDGRAGYCNHAFVAHTADLSSVGPVMYVRMWVRHTTALPTSHVTFVSMPDSAQGGRALRVGGQNGALQWNRESDDATLPAQSPAGVALSRPLPTDGWQCLRFAIDTSAAGLDTWLGDEQVPGLHADGVPTQDVDQQWLTRGTAPRPTALRLGWESYATGDDTVWFDDVAVGSAPIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O86498</accession>
    <name>O86498_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6330</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34644">
        <property type="entry name" value="T34644"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630423.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030831.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6330"/>
    <dbReference type="TCDB" id="1.A.1.27.2">
        <property type="family name" value="the voltage-gated ion channel (vic) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1101771"/>
    <dbReference type="KEGG" id="sco:SCO6330"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6442"/>
    <dbReference type="eggNOG" id="ENOG5032SBH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112040_0_0_11"/>
    <dbReference type="InParanoid" id="O86498"/>
    <dbReference type="OMA" id="WEVRAIT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="3">
        <location>
            <begin position="100"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="207" mass="21659" checksum="6E714D689341A2AE" modified="1998-11-01" version="1">MSDTNSGGGRQAASGPAPRGRLPFRRRVALVAVARPLIVTVGLVTAYYLLPLDERLSAGTLVSLVCGLLAVLLVFCWEVRAITRSPHPRLRAIEGLAATLVLFLVLFAGSYYLLGRSAPGSFSEPLNRTDALYFTLTTFATVGFGDITARSETGRILTMAQMTGGLLLVGVAARVLASAVQAGLHRQGRGPAASPRSGAAEEPEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O86533</accession>
    <name>O86533_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5552</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29082">
        <property type="entry name" value="T29082"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629686.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030305.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="SMR" id="O86533"/>
    <dbReference type="STRING" id="100226.SCO5552"/>
    <dbReference type="GeneID" id="1100992"/>
    <dbReference type="KEGG" id="sco:SCO5552"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5640"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_4_1_11"/>
    <dbReference type="InParanoid" id="O86533"/>
    <dbReference type="OMA" id="EPDRLHR"/>
    <dbReference type="PhylomeDB" id="O86533"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001278">
        <property type="term" value="P:positive regulation of leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="24975" checksum="6644F6B55FAE88D1" modified="1998-11-01" version="1">MDNSSGVGVLDKAALVLSALESGPATLAGLVGATGLARPTAHRLAVALEHHRMVARDMQGRFILGPRLAELAAAAGEDRLLATAGPVLTHLRDVTGESAQLYRRQGDMRICVAAAERLSGLRDTVPVGSTLTMKAGSSAQILMAWEEPERLHRGLQGARFTATALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGRMHAQAIIDAAGRLSEALRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O86598</accession>
    <name>O86598_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6233</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37231">
        <property type="entry name" value="T37231"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630334.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972694.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6233"/>
    <dbReference type="GeneID" id="1101674"/>
    <dbReference type="KEGG" id="sco:SCO6233"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6347"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="O86598"/>
    <dbReference type="OMA" id="GYGAIFC"/>
    <dbReference type="PhylomeDB" id="O86598"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="342" mass="36280" checksum="0E141A080CE10E01" modified="1998-11-01" version="1">MSTPSVRVTIKDVAAAAGVSKGAVSLAFNDKPGVSDATRERIFAVARQLGWAPNSSARSLSRQSVDTVGLAICRPARLLGLEPFYMEFVSGIESVLAERDCSLLLRLVGSLEEEIGLQERWWRERQVGGSILVDFHQEDPRIGPLGRIGLPAVAVGHPSLTGGFPSVWTDDAAAVAEAVRYLAVLGHRRIAHVGGPRGLGHSAIRTTAFERTLSELGLDRGPHVETGFSGEDGARATRSLLLSAERPTAILYDNDIMAVAGLGVAAEMGVSVPDDLSLLAWDDSQLCRLTHPTLSAMSHDVHGFGAQVTRVLFDVLAGKDVTSRPVATPSLVPRASTASPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O86632</accession>
    <name>O86632_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6363</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29457">
        <property type="entry name" value="T29457"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630455.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030860.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6363"/>
    <dbReference type="GeneID" id="1101804"/>
    <dbReference type="KEGG" id="sco:SCO6363"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6475"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="O86632"/>
    <dbReference type="OMA" id="VILAYDC"/>
    <dbReference type="PhylomeDB" id="O86632"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="23907" checksum="321D5CBA65AE9721" modified="1998-11-01" version="1">MTTVLVVDDQPLQRYGFHLLLDSVPETDVVGEAAHGVEAVRKAAELRPDVVLMDVRMPGMDGIEATRRIVAAGGRSRVLVLTTFDLDEYVHAAIRAGASGFLLKDARPDELLAGIRAVASGDAVIAPALTRRLLDEFAQYVPAHRGDAAGDPRLVSLTDREREILVAVGKGWTNGEIAARFVLSESTVKTHVGRVLAKIGARDRIQAVIFAYDHGLARPNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O86633</accession>
    <name>O86633_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6364</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29458">
        <property type="entry name" value="T29458"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630456.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6364"/>
    <dbReference type="GeneID" id="1101805"/>
    <dbReference type="KEGG" id="sco:SCO6364"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6476"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="InParanoid" id="O86633"/>
    <dbReference type="OMA" id="GYRFRQP"/>
    <dbReference type="PhylomeDB" id="O86633"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="158"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="158"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA20095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="28706" checksum="D31E974DAA503F97" modified="1998-11-01" version="1">MTSERTGADGPRASPAPTLSSMRTHATADSSRHRILVVEDDDTIGRHLETGLRGNGYAPTWSRTGSAALTLAARTPYDVLLLDLGLPDMDGLDVARAVRDQYPDLLIVILTARTDDIDVIAGLDAGADDYLVKPFSLTVLLARLRAHLRRRVVATPPQEPVRLADLVLDVVARRCTLHDADIDLRPKEFDLLAVLARHAGEAVSRETLMAEVWDENWFGSTKTLDVTMAGLRRRLAQAADASAHPGGLPRITTLRGHGYRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O86693</accession>
    <name>O86693_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6647</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35056">
        <property type="entry name" value="T35056"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031073.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6647"/>
    <dbReference type="GeneID" id="1102086"/>
    <dbReference type="KEGG" id="sco:SCO6647"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6752"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076605_1_0_11"/>
    <dbReference type="InParanoid" id="O86693"/>
    <dbReference type="OMA" id="VWSFGRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="27722" checksum="3E02012594FD4C6E" modified="1998-11-01" version="1">MALINLNHTDDGYDAYDACPARSVQQETAVGAGAQILLLALLGTAIGMGTAGWLTGLAFAFASWAVLSRALHRSRLPSFGPANRVTLGRATLVGGVTALVADSFRSAPPLSLLVGLTAVALILDGVDGRVARRTGTSTPLGARFDMEVDAFLILVLSVYVALDLGPWVLLIGGMRYVFVAAARVWPWLTAPLPPSTARKTVAALQGVLLLLAGAELLPRPGNAGVVAVALGLLVWSFGRDVRWLWRRSRVPAAPVTAVRELVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O86763</accession>
    <name>O86763_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5636</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35462">
        <property type="entry name" value="T35462"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629766.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030352.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5636"/>
    <dbReference type="GeneID" id="1101075"/>
    <dbReference type="KEGG" id="sco:SCO5636"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5724"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_1_11"/>
    <dbReference type="OMA" id="VHNEEGT"/>
    <dbReference type="PhylomeDB" id="O86763"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="27901" checksum="A9F3EF9A7E137D07" modified="1998-11-01" version="1">MGTTVEGGRSGPRYVQVADEIVQQIRAGVLKPGDMVPSESEMVDRYGVSGGTIRKAMVEVRASGLVETRHGKGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAESEQSGATAKVSVLYIGPMEAPADAAQRLGVPAGTQVLARRRLYFRNGTPVETASSYLPWDVVKDIPELFAENPGGGGIYARLEDHGHEFAEFVETLQARPASKAEATELALSPGAPVVHLIREARTAAGLVVEVCDTLMAADQFVFEYRIPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O86824</accession>
    <name>O86824_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5675</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35795">
        <property type="entry name" value="T35795"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629804.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030381.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5675"/>
    <dbReference type="GeneID" id="1101114"/>
    <dbReference type="KEGG" id="sco:SCO5675"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5761"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085484_0_0_11"/>
    <dbReference type="OMA" id="HDACLAC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="27892" checksum="12CC0D61BFDD9A1F" modified="1998-11-01" version="1">MTGEGRYEEVEAEARTLAALPRRPWRRRPPHWEARVLATGAAVMHGRMAEALDELDTLIAELEPVGLNSQMLRLIARSNRVVALSGLRRYAEAETVANGVLRELNQIAHRAPVSGLETNTLRHLATVLCGLARHEEAEAVVRGNLSRANGPAAGVLHTTLAQSLNGQGRYEEALAEVRRSPPRPPRYAAGHPDLVAAEALYGLGRRAEAEDAVRRSLADCERWLHPAHPRTGEARALLARVTGPKPGEESRGEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O88062</accession>
    <name>O88062_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36837">
        <property type="entry name" value="T36837"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027875.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1602"/>
    <dbReference type="GeneID" id="1097033"/>
    <dbReference type="KEGG" id="sco:SCO1602"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1614"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082391_1_0_11"/>
    <dbReference type="OMA" id="QPWAGRS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="24792" checksum="10A24C964D83E6B4" modified="1998-11-01" version="1">MANKNIPDSAFSDDDGTADPRLSAALAAWSEDRAAVGPVLAALKGARLLVPVVAVLGEVEEDENGLRREKTSDMAVPTLKAGDRTALPAFTSTASLARWDPEARPVAVPVHQALEAAAHEKADTVVLDLAGPVPFELTGAVLLALAEGRTTTDPLADPAVAGAVRAALADEPAVLRAHLGPGRADGTLALVLDPAADAATAARAVAERLAADDTLRARLVRGLDLALLPAGATPPGEPLYVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKF2</accession>
    <name>Q7AKF2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-factor receptor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6071</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2017" name="J. Struct. Biol." volume="198" first="134" last="146">
            <title>Structural and dynamics studies of the TetR family protein, CprB from Streptomyces coelicolor in complex with its biological operator sequence.</title>
            <authorList>
                <person name="Bhukya H."/>
                <person name="Jana A.K."/>
                <person name="Sengupta N."/>
                <person name="Anand R."/>
            </authorList>
            <dbReference type="PubMed" id="28343010"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2017.03.006"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.99 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35863">
        <property type="entry name" value="T35863"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630180.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030630.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="PDB" id="5H58">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.99 A"/>
        <property type="chains" value="A/B/C/D=1-215"/>
    </dbReference>
    <dbReference type="PDBsum" id="5H58"/>
    <dbReference type="SMR" id="Q7AKF2"/>
    <dbReference type="STRING" id="100226.SCO6071"/>
    <dbReference type="GeneID" id="1101512"/>
    <dbReference type="KEGG" id="sco:SCO6071"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6172"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_8_0_11"/>
    <dbReference type="InParanoid" id="Q7AKF2"/>
    <dbReference type="OMA" id="HFRSKHA"/>
    <dbReference type="PhylomeDB" id="Q7AKF2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5H58"/>
        </source>
    </evidence>
    <sequence length="215" mass="23684" checksum="C29F85FC55E5DBF5" modified="2012-05-16" version="1">MARQLRAEQTRATIIGAAADLFDRRGYESTTLSEIVAHAGVTKGALYFHFAAKEDLAHAILEIQSRTSRRLAKDLDGRGYSSLEALMRLTFGMARLCVQGPVLRAGLRLATAGVPVRPPLPHPFTEWREIATSRLLDAVRQSDVHQDIDVDSVAHTLVCSVVGTRVVGGTLEPAGREPRRLAEMWYILIRGMVPVTRRARYVTLAARLEQETGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API8</accession>
    <name>Q7API8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, MmyF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mmyF</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639836.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039528.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095309"/>
    <dbReference type="KEGG" id="sco:SCP1.228c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8173"/>
    <dbReference type="HOGENOM" id="CLU_059021_1_0_11"/>
    <dbReference type="InParanoid" id="Q7API8"/>
    <dbReference type="OMA" id="AGDHWFV"/>
    <dbReference type="PhylomeDB" id="Q7API8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="18399" checksum="B3C1C5D7EB935AA6" modified="2012-05-16" version="1">MATDVTTATAKPPLATIDSAHFRRVLGHFPTGVVVITAMADGEPAGLAVGSFASVSLDPPMVGFFPGKSSTSWPLVQRAGSFVVNVLGDHQQDVCRAFATSGGDKFTGIPWRRASNGAPALHDVIAWIECDIDTVTDAGDHWFVLGRVRDLALSTNTESPLLFFQGRYARVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJP1</accession>
    <name>Q8CJP1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6137</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAD55372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34650">
        <property type="entry name" value="T34650"/>
    </dbReference>
    <dbReference type="PIR" id="T35920">
        <property type="entry name" value="T35920"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733689.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030679.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6137"/>
    <dbReference type="GeneID" id="1101578"/>
    <dbReference type="KEGG" id="sco:SCO6137"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6241"/>
    <dbReference type="eggNOG" id="COG2040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_11"/>
    <dbReference type="InParanoid" id="Q8CJP1"/>
    <dbReference type="OMA" id="HRPRMKA"/>
    <dbReference type="PhylomeDB" id="Q8CJP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="304" mass="32305" checksum="73D5CED85FC4AFD4" modified="2003-03-01" version="1">MTSDFADALASGPLVLDGGLSNQLEAAGHDLGDALWSARLLAEDPEAITRAHLAYFEAGAEVAITSSYQATFEGFARRGIGRERAAELLALSVASAREAARRARTARPERALWVAASAGPYGAMLADGSEYRGRYGLGRGALERFHRPRLEVLAAARPDVLALETVPDTDEAAALLRAVRGLDVPAWLSYTVAGDRTRAGQPLDEAFALAADVDEVIAVGVNCCAPEDVSGAVETAARVTGKPVVAYPNSGETWDAKSRGWRGRSSYTAERVRDWRERGARLVGGCCRVGPETITSIARALPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJT6</accession>
    <name>Q8CJT6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4481</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAD55485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733639.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029686.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4481"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1099921"/>
    <dbReference type="KEGG" id="sco:SCO4481"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4551"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029615_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJT6"/>
    <dbReference type="OMA" id="HFGHELD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="9">
        <location>
            <begin position="552"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD55485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="632" mass="64103" checksum="356DB29C71598930" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK27</accession>
    <name>Q8CK27_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="8" type="ordered locus">SCO1477</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAD55280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733535.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027808.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1477"/>
    <dbReference type="GeneID" id="1096903"/>
    <dbReference type="KEGG" id="sco:SCO1477"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1486"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_11"/>
    <dbReference type="InParanoid" id="Q8CK27"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="PhylomeDB" id="Q8CK27"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="7">
        <location>
            <begin position="212"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="217"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="333"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD55280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="427" mass="45062" checksum="75C85AF830AECD22" modified="2003-03-01" version="1">MGRTRSPNGAQSERGVVRARYPSRGETVDKPKVVLGVSGGIAAYKACELLRRLTESGHEVRVVPTASALHFVGAATWSALSGNPVSTEVWDDVHEVPHVRIGQHADLVVVAPATADMLAKAAHGLADDLLTNTLLTARCPVVFAPAMHTEMWEHPATQENVAALRRRGAVVIEPAVGRLTGVDTGKGRLPDPGEIFEVCRRVLARGVREPDLAGRHVVVSAGGTREPLDPVRFLGNRSSGKQGYALARTAAARGARVTLVAANASMPDPAGVDVVPVGTAVELREAVLRAAADADAVVMAAAVADFRPATYATGKIKKKDDQEPAPITLVRNPDILAEISQTRARSGQVVVGFAAETDDVLANGRVKLKRKGCDLLVVNEVGERKTFGSEENEAVVLGADGSETPVAHGPKEALADTVWDLVARRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK32</accession>
    <name>Q8CK32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1319</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAD55170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027717.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1319"/>
    <dbReference type="GeneID" id="1096742"/>
    <dbReference type="KEGG" id="sco:SCO1319"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1322"/>
    <dbReference type="eggNOG" id="ENOG50334MA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070075_0_0_11"/>
    <dbReference type="OMA" id="GEQNPQD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="36021" checksum="F3098B3F8DBC1FE0" modified="2003-03-01" version="1">MWPGQQPPGGEQNPQNNPYQQPGYQQPNPYQQPGYQQQPGAYGQQQWSTPQPATVPQPATGGGGGGGNRTKLVAIVASLAVVVAAGVTGFLVLGGDKDDKADDGKDKKTSASPTVEKSESPTADPSASGADENPRGGEGAKATVDGWKVVANPRFGTMFDVPADWEIDSTDTSVGFEWEEDGKTDRTTVTAPAYLKSEWCTTDENKDGRKETTALATTGTRGESGAKTTDQAAETRVPWWIYGGYTEPDKKSVKYGKPKPYTTASGIKGSVITAHSEGAPKKGKCDTEGKAITFAFKNGAGDFVTWNLYGPKGVKEEIPEATVQKILATVRLTEEPPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q37</accession>
    <name>Q99Q37_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.278</name>
        <name evidence="1" type="ordered locus">SCP1.75c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639650.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639888.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039376.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095154"/>
    <dbReference type="GeneID" id="1095361"/>
    <dbReference type="KEGG" id="sco:SCP1.278"/>
    <dbReference type="KEGG" id="sco:SCP1.75c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8024"/>
    <dbReference type="HOGENOM" id="CLU_2332466_0_0_11"/>
    <dbReference type="OMA" id="RFDGATC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="10428" checksum="C3F55FCA9AD43582" modified="2001-06-01" version="1">MNRGEIWSLPDGRNILIISLTGLEEAYGAVLAIVLHDSGRYPDTAMSVVIGDPLPCTAVAVNIVQLRVDRFDGAKLLGPVATEAMARVDAALRAVQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QA4</accession>
    <name>Q99QA4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.307c</name>
        <name evidence="2" type="ordered locus">SCP1.47</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639622.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639916.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039348.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095126"/>
    <dbReference type="GeneID" id="1095389"/>
    <dbReference type="KEGG" id="sco:SCP1.307c"/>
    <dbReference type="KEGG" id="sco:SCP1.47"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7995"/>
    <dbReference type="HOGENOM" id="CLU_155283_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="14643" checksum="8C0A29EF9525B18E" modified="2001-06-01" version="1">MSTPAPNSVPFDPHASPADLVAAQRQAAELYAALRAHQTTLPWSREPHDGWPEETERGRENSGQPASPGWTAAEADEFDRLLAELRTATAQVLCHPWWERCAAEGIKGEAMVTARQALKYAEGAAPLGQGDVETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACR8</accession>
    <name>Q9ACR8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.250</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639860.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039552.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095333"/>
    <dbReference type="KEGG" id="sco:SCP1.250"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8195"/>
    <dbReference type="HOGENOM" id="CLU_1958693_0_0_11"/>
    <dbReference type="OMA" id="PEDETWG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="15430" checksum="99530F25D0652071" modified="2001-06-01" version="1">MVEPFIVGALRRGRSVEQFLGPVGSPERPGVRYTEVRTARTSYEVYVHAFEDVGHEGFVDLDVFPPFDQETEEEDFGQLLGTAEDPQDALVLAEKLTGAVRGRWVNQGVVQDEYGDFVRAGRPSGMSAGGWLWPGLRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD09</accession>
    <name>Q9AD09_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.141</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639714.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039440.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095219"/>
    <dbReference type="KEGG" id="sco:SCP1.141"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8088"/>
    <dbReference type="HOGENOM" id="CLU_976317_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="31150" checksum="DE1E834120C2E5F3" modified="2001-06-01" version="1">MLDLPTTTPTARGIFARLDAEWAELCEDASVRAAVADWLMTDHLADDVAAVTDSWVRAVGPEQLLAALRPGHGVLSDALTDAVLRSLLVRATGHDRSATLAARIVVQAMLPAAVRMTRGQVRGTGGRTWDDVGHVVIAALFEVACSGRIHTRPGRPAANLALDALGRVCRELAADREAAGEDLAAAEHLADPTPGPAARAHAAAIHQAAHAAGLTTEASIGEAEASNARLELLELVLEAMEHGSISHADGQAIAWHYTTTPVPDAQAAHRAGTTAAAWRRRRSRAVGRLKSSLRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADB5</accession>
    <name>Q9ADB5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ordered locus">SCO5353</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629493.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030202.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5353"/>
    <dbReference type="GeneID" id="1100793"/>
    <dbReference type="KEGG" id="sco:SCO5353"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5433"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_11"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="PhylomeDB" id="Q9ADB5"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="72"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="463" mass="49762" checksum="853CBB7179A5E399" modified="2001-06-01" version="1">MSRSAHPAGPRHADVLPEGHYTAPADDLNALDPKVWARTVGRDADGVVTVGGIPVTQLAEEYGTPAYLLDEADFRERARAWRTAFGDDADVFYAGKAFLSRAVVRWLDEEGLNLDVCSGGELATALSAGMPAERIAFHGNNKSPEEIERAVRAGVGRIVLDSFQEIVRVAHIAQSLGKRQRVQIRITVGVEAHTHEFIATAHEDQKFGIPLAGGQAAEAVRRALKLDGLEVIGIHSHIGSQIFDMSGFEVAAHRVVGLLKDIRDEHGVELPEIDLGGGLGIAYTSDDDPREPHEIAKALTEIVTRECEAARLATPRISVEPGRAIVGPTAFTLYEVGTVKPLEGLRTYVSVDGGMSDNIRTALYDAEYSVALASRTSDAEPMLVRVVGKHCESGDIVVKDAFLPGDLAPGDLIAVPATGAYCRSMASNYNHALRPPVVAVRDGAARVVVRRETEEDLLRLDVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-25" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADK2</accession>
    <name>GREA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">greA</name>
        <name type="ordered locus">SCO4965</name>
        <name type="ORF">2SCK31.25c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629117.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974011.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ADK2"/>
    <dbReference type="SMR" id="Q9ADK2"/>
    <dbReference type="STRING" id="100226.SCO4965"/>
    <dbReference type="GeneID" id="1100406"/>
    <dbReference type="KEGG" id="sco:SCO4965"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5045"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADK2"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="PhylomeDB" id="Q9ADK2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176978" description="Transcription elongation factor GreA">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <sequence length="165" mass="17843" checksum="D2575DE4AD32CB06" modified="2001-06-01" version="1">MTQTSENVTWLTQEAYNKLKEELEYLTGPARTEISAKIAAAREEGDLRENGGYHAAKEEQGKQELRVRQLTQLLESAKVGEAPAADGVVAPGMVVTIAFDGDEDDTLTFLLASREYASSDIETYSPQSPLGSGVLGHKVGDDAQYELPNGKPASVRILKAEPYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK11</accession>
    <name>Q9AK11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7717</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631755.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031852.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1103155"/>
    <dbReference type="KEGG" id="sco:SCO7717"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7839"/>
    <dbReference type="HOGENOM" id="CLU_126034_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176622" evidence="1">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="13796" checksum="F90550F2907C58B1" modified="2001-06-01" version="1">MKKLASALLSAVLLGGMSVAAAPAASAVTAPGATASAAPGCVTETKEVSKGYGTITVCVNEDGSARAYGDLHCTAFGAVLVMWEIGWETASGVKVSTVATAGWGDDDIEFDVDPSADTDGIKGITGVDEIYLATIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK58</accession>
    <name>Q9AK58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4059</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628241.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974904.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4059"/>
    <dbReference type="GeneID" id="1099495"/>
    <dbReference type="KEGG" id="sco:SCO4059"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4121"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_11"/>
    <dbReference type="InParanoid" id="Q9AK58"/>
    <dbReference type="OMA" id="RLWQFEP"/>
    <dbReference type="PhylomeDB" id="Q9AK58"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="12131" checksum="26F57EC97F1EDFE9" modified="2001-06-01" version="1">MTAPALPAVCAALGDPTRWEILARLGEAPVSASELARALPVSRQAIVKHLEVLREVGLVESERRGREVVHVAVGARLGALARELDRIGRSWETRLLRIKTLAEQPEANRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWG1</accession>
    <name>Q9EWG1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4960</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629112.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974016.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4960"/>
    <dbReference type="GeneID" id="1100401"/>
    <dbReference type="KEGG" id="sco:SCO4960"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5040"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_8_11"/>
    <dbReference type="OMA" id="AHTYACW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="2">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="18509" checksum="A0B495EC7210A5BD" modified="2001-03-01" version="1">MRERHASRNARRAREFEAFVAGAAGRLLHAATLLTAEAPDANPRARRLLALSLAHTYADWDRLHGEDPYDRARQHLATRFARAAWHRYGALGRTRRHPAGPLGGLAPQERLLLVLRLYEGVAEEQTAALLGLPVERVRTICDRATAALLRPPPSPARPVTADARAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWK4</accession>
    <name>Q9EWK4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7789</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631819.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031912.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7789"/>
    <dbReference type="GeneID" id="1103226"/>
    <dbReference type="KEGG" id="sco:SCO7789"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7905"/>
    <dbReference type="HOGENOM" id="CLU_2720480_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="72" mass="7423" checksum="FA3EDCA05CA730BC" modified="2001-03-01" version="1">MLLPGLAHAAARQRSLFGVEASGAGLPLARDWVFMEHPPARMHIGLVVDEAGPSMAVVLDQTRAAATAGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWT7</accession>
    <name>Q9EWT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0734</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625038.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027322.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0734"/>
    <dbReference type="GeneID" id="1096157"/>
    <dbReference type="KEGG" id="sco:SCO0734"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.724"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_4_11"/>
    <dbReference type="InParanoid" id="Q9EWT7"/>
    <dbReference type="OMA" id="VANIAMP"/>
    <dbReference type="PhylomeDB" id="Q9EWT7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="47"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="424" mass="44865" checksum="6A4EEB5E72104F5C" modified="2001-03-01" version="1">MPSRAARTPITDASGGPSGRRVALLFPKRKKPEREPMPTRPEDWPPLTPGERSVAIEVLVHGPLSRSEIARRLGLSPGSLTRLTKPLIEQRLLVEVPEAGGGPDGGRQGRPSRPLDVVADSRYFLGFKITQDMVYGVVTTLRSEIVARHDRALATHDPAEVAGLLAGMTAELSRGRSGVAGIGIGVGGLVEDRAVVGESPFLGWRGVPLAALVQERTGLPVVVENDTAAFVEAETWFGAGRGLDRFVVLTIGAGIGYGLVLGGRRVPYAGDEDRGFGRHWILDPHGPLTPDGRRGSAVSLLTIPNMRYQVRAATGHDRTYEEILASAAAGEPMAARVVAEAGRALGTLVAQIANFVMPQKILLAGEGVGLMEVAGDVVAETVRNHRHPRAAPVGLETRVSDFHDWARGAAVPAIQVLVLGAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX61</accession>
    <name>Q9EX61_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7694</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631733.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031836.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7694"/>
    <dbReference type="GeneID" id="1103132"/>
    <dbReference type="KEGG" id="sco:SCO7694"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7814"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_36_0_11"/>
    <dbReference type="OMA" id="GFARTTM"/>
    <dbReference type="PhylomeDB" id="Q9EX61"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="20782" checksum="8EDB51AE0F6EAE41" modified="2001-03-01" version="1">MSRSDAGRPAPTGADADRRTMVLESAMATFARFGYRKTSMEEVARAAHISRPGLYFLFSSKESLFRAAVTQALHRDITAVERALADGDRPLPERLVEAFDHWAGRYVGPLTRDVATVIEANPGILGEVVEVLPRRFEELVTDAITVATGREGAVRIAQTMISASTGLKHQVGSRESYLERLTVAVGLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2L0</accession>
    <name>Q9F2L0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted penicillin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3771</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627961.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029224.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3771"/>
    <dbReference type="GeneID" id="1099207"/>
    <dbReference type="KEGG" id="sco:SCO3771"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3830"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025328_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2L0"/>
    <dbReference type="OMA" id="EAFAHSC"/>
    <dbReference type="PhylomeDB" id="Q9F2L0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176657" evidence="2">
        <location>
            <begin position="39"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="4">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="271"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC10309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="546" mass="56869" checksum="2BA4FC2811DD0BA6" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2R8</accession>
    <name>Q9F2R8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4471</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029676.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4471"/>
    <dbReference type="GeneID" id="1099911"/>
    <dbReference type="KEGG" id="sco:SCO4471"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4540"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040541_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2R8"/>
    <dbReference type="OMA" id="GAHFTYF"/>
    <dbReference type="PhylomeDB" id="Q9F2R8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176666" evidence="2">
        <location>
            <begin position="24"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="432" mass="47006" checksum="19F27DB3ED71AACF" modified="2001-03-01" version="1">MRTSNRTLTRRGMLGLGAGAAAAVGLAGCGTGSHSSSDGSHQAPGAGKPSPSGSGKAPAKPIGDGSTSYTGKQPHQPDAPVPLEPGQTPPQFVVFSWDGAGEVGNGLFPRFLDLAQEHGAHMTFFLSGLYLLPESKKRLYDPPNNPRGASDIGYLTDEHIKATLTNVRRAWLDGHEIGTHFNGHFCGGGGSVGNWTSAQWRSEIDQAKSFVKEWRTNSGWTDLPSLPFDYDKELVGGRTPCLLGQDRLLPTARELGWRYDASSPGGRQVWPVKKDGIWDLPLQQIPFPGHSFEVLSMDYNILANQSVNSTKAPAYNYPGWREQATKAYISGFKRAYESNRAPFFIGNHFEEWNGGIYMDAVENALKHIAREKEKGEDIRLVSFRQFTDWLDVQKPEVLAKLRTVEVGQRPAGGWNAFLKETPASSGAPANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2U3</accession>
    <name>Q9F2U3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628781.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029768.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4619"/>
    <dbReference type="GeneID" id="1100059"/>
    <dbReference type="KEGG" id="sco:SCO4619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4692"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146089_0_0_11"/>
    <dbReference type="OMA" id="VIKRNHF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16104" checksum="49AC9D116223DB95" modified="2001-03-01" version="1">MYPEHTPHVPAQRAVEVHQPTPYPPTVAVPAPLVPVQPNAVPAVASVVLPDGRVVTGYAIEPTRPEPIAAKPAVSRTAVNVALGGVGFLAVCGGLILLTSFIAALTAFITQLITLAAVIFGGWIAVQILGTHGHRAAGTTVNIRKAVIKRNHFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L5</accession>
    <name>Q9F3L5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5249</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629395.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973721.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F3L5"/>
    <dbReference type="STRING" id="100226.SCO5249"/>
    <dbReference type="GeneID" id="1100690"/>
    <dbReference type="KEGG" id="sco:SCO5249"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5334"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056341_0_0_11"/>
    <dbReference type="OMA" id="QGGTYRV"/>
    <dbReference type="PhylomeDB" id="Q9F3L5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="468" mass="52193" checksum="9E8414D40ACA63EF" modified="2001-03-01" version="1">MSVGEEVRTEQTRPQQSLGTAAARNLATTTKSVPQMQEISSRWLLRSLPWVDIQGGTYRVNRRLTFAVGDGRVTFVKTGDRVEVVPAELGELPALRSYEDDEVLSELAQRCEQREFGPGEVIASFGARADEVYLLAHGKVEKIGTGPYGDDAVLGVLADGAYFGDQALLDGDAIWEYTARTVTACTVLVLPRQEVDQVAERADSLREHLEQRRSIPEQRTNRHGEKEIDLAAGHSGEPDIPHTFVDYEARPREYELSVAQTVLRIHSRVADLYNQPMNQTEQQIRLTVEALKERQEHELINNREFGLLHNCEYDQRIQPHDGVPGPDDLDELLSRRRGTKLLLAHPRAIAAIGRELNKRGLVPETIDVAGNRIPTWRGVPIYPCNKIPVTEARTSSIIAMRTGEQDQGVIGLRATGIPDEIEPSLSVRFMGINEQAVIKYLVTAYYSAAVLVPDALGVLENVEIGRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC52</accession>
    <name>Q9FC52_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7134</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631195.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031451.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7134"/>
    <dbReference type="GeneID" id="1102572"/>
    <dbReference type="KEGG" id="sco:SCO7134"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7235"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="InParanoid" id="Q9FC52"/>
    <dbReference type="OMA" id="ARTIEWH"/>
    <dbReference type="PhylomeDB" id="Q9FC52"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="854"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="923" mass="98698" checksum="B7560B5054A5B02C" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCB0</accession>
    <name>Q9FCB0_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative MutT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1203</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625492.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1203"/>
    <dbReference type="GeneID" id="1096626"/>
    <dbReference type="KEGG" id="sco:SCO1203"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1202"/>
    <dbReference type="eggNOG" id="COG4119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118065_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCB0"/>
    <dbReference type="OMA" id="HMGGPLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="153" mass="16821" checksum="9A9F3C8C5377BE40" modified="2001-03-01" version="1">MRRSAGLLLHRRAPGGGLQVLLGHMGGPFYSRRDAGAWTVPKGEYDSGEPAWEAARREFEEELGLPPPEGEAVPLGEVRQAGGKLVTVWAVAADLDPATVVPGTFRMEWPPRSGRTEEFPELDRVAWFGLDRAREVIVKAQAAFLDRLAEHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCB6</accession>
    <name>Q9FCB6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO1251</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625539.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027670.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1251"/>
    <dbReference type="GeneID" id="1096674"/>
    <dbReference type="KEGG" id="sco:SCO1251"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1251"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="InParanoid" id="Q9FCB6"/>
    <dbReference type="OMA" id="GVAHIKD"/>
    <dbReference type="PhylomeDB" id="Q9FCB6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176704" evidence="10">
        <location>
            <begin position="23"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC01475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="468" mass="48975" checksum="FD364A0F85555529" modified="2001-03-01" version="1">MTEVLLLLVAILLSLACGAFVAAEFSLTTVERGELERAAARGERGAASALKGVRNLTFQLSGAQLGITVTNLVVGMLAEPSVAALIAGPLEDLGVSRSAASSLALVLGTALSTVFLMIVGELVPKNWAISSPLAVAKRVGGPQRWFSAVFRPFITHLNNTANRVVRRFGVEPAEELASARGPQELAALARHSAKEGALEADTAELFVRTLNLADLTAQQVMTPRVQVVALDVRATCEDVANATRATGLSRFPVYQDGLDAVVGTAHVKDVLAVPAERRPTMPVAELMREPLLVPESLTVDRLLDRLSGRRTMAVVIDEYGGTAGVATLEDIVEEVVGQVRDEHDPHETPDLDPAGTDEAGHALYWADGSARVDRLERLGLRVPEGPYETVAGLVAAGLGRIPAVGDSLDVAGWRLDVVDATGRRAARVLMHAPLDDGADGADGADRVDGSGAAESGPGGGENEGEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCG2</accession>
    <name>Q9FCG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4207</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628382.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974764.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099647"/>
    <dbReference type="KEGG" id="sco:SCO4207"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4271"/>
    <dbReference type="eggNOG" id="COG4954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843035_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCG2"/>
    <dbReference type="OMA" id="KGARMHP"/>
    <dbReference type="PhylomeDB" id="Q9FCG2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018988">
        <property type="entry name" value="DUF2000"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09391">
        <property type="entry name" value="DUF2000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16987" checksum="78CCE81E34036B85" modified="2001-03-01" version="1">MSTHEAAPQTPRAPEAETPVRFDTKIAVLLREDLETWQRLNVTAFLVSGLGKQFPEVIGEPYEDADAVGYLPMFRQPVLVFEGTKETLTTAHARVLSRALPRALFTSDLFTTGNDRDNRAAVRAVATADLDLVGLAVYGPKNAVDKVLKGARMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X0</accession>
    <name>Q9K3X0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4374</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628543.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029614.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4374"/>
    <dbReference type="GeneID" id="1099814"/>
    <dbReference type="KEGG" id="sco:SCO4374"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4442"/>
    <dbReference type="eggNOG" id="COG5006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057295_0_2_11"/>
    <dbReference type="InParanoid" id="Q9K3X0"/>
    <dbReference type="OMA" id="MWAAYIV"/>
    <dbReference type="PhylomeDB" id="Q9K3X0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015565">
        <property type="term" value="F:threonine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="149"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="29843" checksum="764BEB0392A4469B" modified="2000-10-01" version="1">MPDGAPGGRFGALGPVGLVLAGGISVQFGAALAVSLMPRAGALGVVTLRLAVAAVVMLLVCRPRLRGHSRADWGTVVVFGIAMAGMNGLFYQAVDRIPLGPAVTLEVLGPLALSVFASRRAMNLVWAALALAGVFLLGGGGFDGLDPAGAAFALAAGAMWAAYIVFSARTGRRFPQADGLALAMAVGALLFLPLGIVESGSKLIDPVTLTLGAGVALLSSVLPYTLELLALRRLPAPTFAILMSLEPAIAAAAGFLILDQALTATQSAAIALVIAASMGAVRTQVGRRRAKALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X8</accession>
    <name>Q9K3X8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO1356</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625641.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977470.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1356"/>
    <dbReference type="GeneID" id="1096779"/>
    <dbReference type="KEGG" id="sco:SCO1356"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1364"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_4_11"/>
    <dbReference type="InParanoid" id="Q9K3X8"/>
    <dbReference type="OMA" id="GVINCPC"/>
    <dbReference type="PhylomeDB" id="Q9K3X8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176726" description="Cytochrome bc1 complex Rieske iron-sulfur subunit" evidence="12">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB95813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="165" mass="15473" checksum="6AA3A29864D2A092" modified="2000-10-01" version="1">MTSAPFHPAAGPARRTVVAAAGAAGLTAVLAACSDSDDGASGDGGTAPSGSPSQEAGGGGSGGGENAGAGAALAATADIPEGGGKVFPDQKVVVTQPAAGDFKAFSATCTHQGCAVKSVADGLINCPCHNSSFSITDGSVQGGPAPKPLPAVQITVSGDSIRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Y5</accession>
    <name>Q9K3Y5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1348</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625633.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027736.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1348"/>
    <dbReference type="GeneID" id="1096771"/>
    <dbReference type="KEGG" id="sco:SCO1348"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1355"/>
    <dbReference type="eggNOG" id="ENOG5032SI8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138456_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3Y5"/>
    <dbReference type="OMA" id="AGVLVYC"/>
    <dbReference type="PhylomeDB" id="Q9K3Y5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13812" checksum="1D0944CA2E8A0EC4" modified="2000-10-01" version="1">MSDRHVFEYALLRVVPRVERGECVNAGVLVYCRARSYVGARTHLDEDRLLALDPQVDLPGVRAALRAVEGVCAGGDAAGQAAEDDPGRRFRWLIAPRSTVVQPGPVHTGLTADPAAETERLLELLVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Z0</accession>
    <name>UNG2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uracil-DNA glycosylase 2</fullName>
            <shortName>UDG 2</shortName>
            <ecNumber>3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ung2</name>
        <name type="ordered locus">SCO1343</name>
        <name type="ORF">2SCG61.25c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625628.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977484.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3Z0"/>
    <dbReference type="SMR" id="Q9K3Z0"/>
    <dbReference type="STRING" id="100226.SCO1343"/>
    <dbReference type="GeneID" id="1096766"/>
    <dbReference type="KEGG" id="sco:SCO1343"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1350"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_0_11"/>
    <dbReference type="InParanoid" id="Q9K3Z0"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="PhylomeDB" id="Q9K3Z0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176150" description="Uracil-DNA glycosylase 2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="227" mass="25205" checksum="775BFB5A984C2982" modified="2000-10-01" version="1">MTDIAMLPESWREVLGGELQQPYFKELMEFVEEERANGPVYPPREEVFAALDATPFDRVKVLVLGQDPYHGEGQGHGLCFSVRPGVKVPPSLRNIYKEMHAELDTPIPDNGYLMPWAEQGVLLLNAVLTVRAGEANSHKSRGWELFTDAVIRAVAARTDPAVFVLWGNYAQKKLPLIDEARHVVVKGAHPSPLSAKKFFGSRPFTQINEAVAGQGHEPIDWTIPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K447</accession>
    <name>Q9K447_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7200</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631257.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031504.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7200"/>
    <dbReference type="GeneID" id="1102638"/>
    <dbReference type="KEGG" id="sco:SCO7200"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7299"/>
    <dbReference type="eggNOG" id="COG0748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134363_0_0_11"/>
    <dbReference type="OMA" id="RAPIWIY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="20130" checksum="86187BF5AE37413B" modified="2000-10-01" version="1">MTPDEADPARPRVPAGWRRLAARAPILLFRAGLGPLLGRRFLLLHHVGRVSGSDRRAVLEVVAYEAPYRCWTVASGFGPRSDWYRNLRAQPKTVVQFGNRHHAVTARFLASDEGADIMTDYGRRHPRTARRLCAYLGLPADGSESALREAGRAIPFVRLEADTCPPDAPRRAGRDTPTPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C7</accession>
    <name>Q9K4C7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5384</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629523.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973613.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5384"/>
    <dbReference type="GeneID" id="1100824"/>
    <dbReference type="KEGG" id="sco:SCO5384"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5464"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K4C7"/>
    <dbReference type="OMA" id="YNYFPAK"/>
    <dbReference type="PhylomeDB" id="Q9K4C7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="23633" checksum="2B4E114F7B7C3DA1" modified="2000-10-01" version="1">MAEGLRERKKRQTRQYISDVATGLFLERGFEAVTVAEVADAANVSVNTVYNYFPAKEDLFLDRSKGVIDRLSRWVRGRRDGESAAGAVLRELRDEVESVSPRVGLMDGYATFMKVIQDSPALRSRMWAIGQEVLLNLEHTLREETGSADDDMTPTLMAGQINWLHGTVLAAIGGRMVAGGKPSEVSRDMLLLLDEMEELLSEKVLNYAVRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4J3</accession>
    <name>Q9K4J3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7321</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631376.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031587.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7321"/>
    <dbReference type="GeneID" id="1102759"/>
    <dbReference type="KEGG" id="sco:SCO7321"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7424"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066586_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4J3"/>
    <dbReference type="OMA" id="VCGDAWA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="354" mass="36460" checksum="2E268B423C7563EA" modified="2000-10-01" version="1">MPRVWDVPVHDSTRVRDARVAAEHAAAVAGLDEQRTSAAALVATELATNLLKHAGGGRVVVDVVAPPVLAADREPRPRVQIATVDHGPGMADVSAALRDGFTTTTGSLGAGLGTCARVADDFDLHSAPGRGTVVVARIGVPEARAADSGPAARLRAGAVNVPFGGAEYSGDAWAWVRDRDLVTLMLADGLGHGPEAARASTAAVEALRASAHLAPGEAVRRLDRALSGTRGAAVAVAQVDTRASVLRFAGVGNIGARLCEGGTWRHLVSRPGIVGTHRPTTLREEQAAWADDRVLVLHSDGLPSRWSPTSDTCRTTTDPAVTAAVTIRDASSSARPVRDDTAVAVLAPTPPDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXP8</accession>
    <name>Q9KXP8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1502</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625782.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1502"/>
    <dbReference type="GeneID" id="1096928"/>
    <dbReference type="KEGG" id="sco:SCO1502"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1511"/>
    <dbReference type="eggNOG" id="ENOG5033A8E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167343_0_0_11"/>
    <dbReference type="OMA" id="RRTFWFS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="118" mass="13187" checksum="8E976861292402D8" modified="2000-10-01" version="1">MFRRTFWFGTGVAAGVWATTKVNRKLKQLTPDSLAATAANKALDVGTRVRDRAVGFALDVRDNMAQREAELDDALGLKAPVDRELPAPRHHAAIENSKDPEYVVDDRTTHSYNRNEDH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXT4</accession>
    <name>MURQ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="1">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="1">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murQ</name>
        <name type="ordered locus">SCO4307</name>
        <name type="ORF">SCD95A.40c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="1"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628479.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029570.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXT4"/>
    <dbReference type="SMR" id="Q9KXT4"/>
    <dbReference type="STRING" id="100226.SCO4307"/>
    <dbReference type="GeneID" id="1099747"/>
    <dbReference type="KEGG" id="sco:SCO4307"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4375"/>
    <dbReference type="eggNOG" id="COG2103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049049_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KXT4"/>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="PhylomeDB" id="Q9KXT4"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016803">
        <property type="term" value="F:ether hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000249667" description="N-acetylmuramic acid 6-phosphate etherase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <sequence length="311" mass="31864" checksum="B71E1DA9F96DBFC8" modified="2000-10-01" version="1">MTSTPHHPDLRSQLETLTTEAFRPELAEIDQLPTLDIARLMNGEDATVPAAVAERLPEIAAAIDAVAVRMARGGRLIYAGAGTAGRLGVLDASECPPTFNTGPGQVVGLIAGGPDAMVTSIEGAEDSPELARADLDALALTADDTVVGVSASGRTPYAVGAVEYARSLGALTVGLACNRDSALAAAAEHGIEVVTGPELLTGSTRLKAGTAQKLVLNMLSTITMIRLGKTYGNLMVDVRASNEKLRARSRRIVALATGAADDDIERALTATDGEVKDAILVLLADVDGPTAARLLAESGGHLRAAMAAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXV6</accession>
    <name>Q9KXV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628457.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029555.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4285"/>
    <dbReference type="GeneID" id="1099725"/>
    <dbReference type="KEGG" id="sco:SCO4285"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4353"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="InParanoid" id="Q9KXV6"/>
    <dbReference type="OMA" id="FEPEVIC"/>
    <dbReference type="PhylomeDB" id="Q9KXV6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="326" mass="32584" checksum="64A51C883D7C5436" modified="2000-10-01" version="1">MKAALAGPGGELLHQARRATGRERGPEAVVAGILDFAAELRAYGADRFGEPARAAGVAVPGIVDAERGVAVYAANLGWRDVPLRTLLGERLGSIPVALGHDVRTGGLAEGRIGAGRGADRFLFVPLGTGIAGAIGIDGRVEAGAHGFAGEIGHVVVRPGGIACPCGQRGCLERFASASAVSQAWAQACGDPGADAADCAKAVESGDARALAVWQDAVDALADGLVTALTLLDPRVLIIGGGLAEAGETLFTPLRDAVRRRVTFQKLPEIVPAALGDTAGCLGAGLMAWDLLDTAAPSAPSAPSAPSAPSSTASTAATAATPPEVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXY0</accession>
    <name>Q9KXY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3868"/>
    <dbReference type="GeneID" id="1099304"/>
    <dbReference type="KEGG" id="sco:SCO3868"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3939"/>
    <dbReference type="eggNOG" id="ENOG502ZHPE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112913_0_0_11"/>
    <dbReference type="OMA" id="MATRWDE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="208" mass="22832" checksum="99DDE7A1B6A8ACD1" modified="2000-10-01" version="1">MPACGVPSAELRPRGDGLGTGEQLVTIAAVLVGALTTHATNYLMERSRNRNQLLTRWDDKKVDAYGEYVDAAKLRIAASVPLYEAREGLRETHRPEEDLRDDLAQASLRWGAAFERVMLLGGDDAIESGHELNVVLAEIDWQATGRVDGSLEEWRERHRAAFRAINAFHEAARADLGIRGRVTGEKHPERDLLVPPARGSSTGSPTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXY2</accession>
    <name>Q9KXY2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3866</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628053.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029280.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3866"/>
    <dbReference type="GeneID" id="1099302"/>
    <dbReference type="KEGG" id="sco:SCO3866"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3937"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074577_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXY2"/>
    <dbReference type="OMA" id="VIFEMNC"/>
    <dbReference type="PhylomeDB" id="Q9KXY2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="77"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="31347" checksum="018C90DE1026952C" modified="2000-10-01" version="1">MRNGPGTLGKAALATRWLNAHLREHPRRAVVELPSGGRFAVDTQDLIQRYLYLFGAWEPHLTGWLRRRLRPGDGFVDVGANIGVFSVLAARLVGESGRVVAIEASADVHRRLVGNARLNGLGNIRALNAAVSDRTRTLTFALASSRNTGANSIVPYDGPVESSFRTEARPLPDLLDTAEIATVRVIKIDVEGAEGSVVRGLAPMLGALRPDAEIAVEVAPERMARLGDRVDDLLAVMRDAGFHGYRLPNDYAPGSYPPALSGAPRAPVRLRGPVTGESDLVFSRVDAERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY25</accession>
    <name>Q9KY25_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626612.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976439.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2365"/>
    <dbReference type="GeneID" id="1097799"/>
    <dbReference type="KEGG" id="sco:SCO2365"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2404"/>
    <dbReference type="eggNOG" id="COG4110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091689_0_0_11"/>
    <dbReference type="OMA" id="YGWGLQW"/>
    <dbReference type="PhylomeDB" id="Q9KY25"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="245" mass="27432" checksum="EAE5956CD22B69DE" modified="2000-10-01" version="1">MGFLDGLWRGRESEFDSGSAATNSIQLTKRHSQVSLTKQGAATGNLRVNLSWRMRTSDISGVQRESLLRHPFKALKPPEVVGHSQSMVNVDLDLGCLYELKDGTRGVVQPLGGFLGDVNAPPYVKLSGDDRFGSASGETLYVNLDHKDEIKRLLLFAYIYDQTPAFDRTHAVVTLYPSNGPRIEIGLDERHPQARSCAVVMIENVKDEILVRREVKFVYGFQGELDRLYGWGLQWGRGHKSKAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYA5</accession>
    <name>Q9KYA5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6928</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630995.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031310.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KYA5"/>
    <dbReference type="STRING" id="100226.SCO6928"/>
    <dbReference type="GeneID" id="1102366"/>
    <dbReference type="KEGG" id="sco:SCO6928"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7034"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_397901_0_0_11"/>
    <dbReference type="OMA" id="FHANRAG"/>
    <dbReference type="PhylomeDB" id="Q9KYA5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027573">
        <property type="entry name" value="Methyltran_FxLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04364">
        <property type="entry name" value="methyltran_FxLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="6">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB92590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="696" mass="75887" checksum="5C08C043308CFCBA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYC4</accession>
    <name>Q9KYC4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630975.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031291.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102345"/>
    <dbReference type="KEGG" id="sco:SCO6906"/>
    <dbReference type="eggNOG" id="ENOG5031UTA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_514726_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032557">
        <property type="entry name" value="DUF4935"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16289">
        <property type="entry name" value="PIN_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_12" evidence="2">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="529" mass="57434" checksum="87075B0602262E11" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYT3</accession>
    <name>Q9KYT3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5682</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629810.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030387.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5682"/>
    <dbReference type="GeneID" id="1101121"/>
    <dbReference type="KEGG" id="sco:SCO5682"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5770"/>
    <dbReference type="eggNOG" id="ENOG5031JHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041277_0_0_11"/>
    <dbReference type="OMA" id="WAATRRS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB91118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="377" mass="37614" checksum="A35DA0437F044C46" modified="2000-10-01" version="1">MRKTFGDRVATDAGWPVERYAWAGCAVAVAGFAQVSDLVTHRVWGWAAAAGYTLAAFLASGAVPRPAARAAAVAGAVVAPLVGLVVTGLGQSEVAVIERSGRLLAATGSPYVTAPSAVGDFNPYLPGMALFGLLPGDPRWWLGGVFVASLGAAGLRSPALLLACPLVALPLAVGGVDLPVAGLMCLGLALAGRGRPGGAGLALGAAAALKWTAWPALPVALALVAVRQGGRPALRCAGVGLGTGTAVVLPFALTDPAGFFRNVVAFPFGLTATDSPAGSPLPGRLLAAHVPGGTVIALALLTVGALLTGASLAVRPPETLRAAAGRLALGLGLATALMPATRFGYLVYPLLLAALAHGAARRDPEVTGRPVERTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYY7</accession>
    <name>Q9KYY7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7542</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031736.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7542"/>
    <dbReference type="GeneID" id="1102980"/>
    <dbReference type="KEGG" id="sco:SCO7542"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7656"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618077_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYY7"/>
    <dbReference type="OMA" id="WMRDTYV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176779" evidence="4">
        <location>
            <begin position="34"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB90900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="49286" checksum="E358E419B91D5EBB" modified="2000-10-01" version="1">MTDAEYGLPRRSLLAGAAGAGAAFALPAGAAQAAPAASPQAGAERRHPRNWPDPEPYGAADTRADLWPREDNSFVLPLELRPRDQERGTVWMRDTYVNCFVVDGRPLYVATGTTRVPGLEAAGPWNDGIFVWLAPSLDGPWRLADTTGIRPGAERGKVWSPEFAGENRPGRTVVAPWQEYWHDEQFGKRGQAWAPELHYFRDTWYLVACMGDHSRKVGSFMLVSEGGVEGPYRLVEGNLDKPFGDSFIGGPKFIEPGAYHHIDGGLFSEGDDAWLVLHNDLYAKFRDDMEDIVTTTDLPRFRQTPYSPEPYLEGAYVFKYRGKYHLVHAAWDRTSVNADGTVRQAYDVPAAGRVQYQYDAIVAVADRFEGPYSKRYTAGVGAGHNNFFVDHRGGLWATYFLNPAAGYWSGASRVAESAVPGVVRLEWTGPAGGRLYVKRGSGGPGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZH9</accession>
    <name>Q9KZH9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625458.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977665.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1166"/>
    <dbReference type="GeneID" id="1096589"/>
    <dbReference type="KEGG" id="sco:SCO1166"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1164"/>
    <dbReference type="eggNOG" id="ENOG502ZHPN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2169575_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="11809" checksum="C3CCFA7A44701297" modified="2000-10-01" version="1">MPSRTQSPTGSQGRVGVGPQGVLRVAPRNRHERGSVFRTESGSGREGGDIMSKNAKVAAGGVAAGLILLIWLPWWAALLIVLGVPAAAYLTLDPSQRRRLRRVSRKEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Z7</accession>
    <name>Q9L0Z7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1462</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977363.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1462"/>
    <dbReference type="GeneID" id="1096888"/>
    <dbReference type="KEGG" id="sco:SCO1462"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1471"/>
    <dbReference type="eggNOG" id="COG2732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121832_1_1_11"/>
    <dbReference type="OMA" id="GLMDRCA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="12330" checksum="9D15B89FC1BAE04F" modified="2000-10-01" version="1">MTEDSAGRLVVTLDLGGVTDKAGLMDRCARDLALPDRFGRNWDSLADSLADPSVWPEGAADRGLVLVVAGWRAYAEARPDEWAVAEEVFAEATDRGPGLFVTLGPGGSSREAADQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1C5</accession>
    <name>Q9L1C5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1557</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625835.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977267.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1557"/>
    <dbReference type="GeneID" id="1096988"/>
    <dbReference type="KEGG" id="sco:SCO1557"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1569"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067080_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1C5"/>
    <dbReference type="OMA" id="YQDDAES"/>
    <dbReference type="PhylomeDB" id="Q9L1C5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176822" description="Lipoprotein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB76076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="29046" checksum="66298B858E7B2CF6" modified="2000-10-01" version="1">MRNTAKFTTAVLAAGALTLGLTACGSDKDSASDTSGPLVVAASPTPHAEILDYVKDNLAKDAGLDLEVKEFTDYVTPNTATEDGSVGANYFQTQPYLDEFNKKNGTHIVSVVDVHLEPLGLYSHKVKKADDLKSGATVAVPNDTVNEGRALQLLAANGIITLKDGAGTAATPSDITENPKKLEFKELEAAQTPRSLDDVDAAVVNGNYAIEADLKPAQDALVLESAKGNPNSNLLAVKEGHEDDPRVKKLAKLLNSPEVKKFIEDTYAGAVLPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1L7</accession>
    <name>Q9L1L7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5427</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629565.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973571.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5427"/>
    <dbReference type="GeneID" id="1100867"/>
    <dbReference type="KEGG" id="sco:SCO5427"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5508"/>
    <dbReference type="eggNOG" id="ENOG5033U9S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229332_0_0_11"/>
    <dbReference type="OMA" id="TRWQAYV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="25916" checksum="B7817268EAFD134B" modified="2000-10-01" version="1">MWRVRRPSPGPSQSGPPFNALAARRLRAALNMGPEHVAHGIRVSYGLPYVSPDLVIAWERGTALPEGPELTALAGVLWCSPGELIGRPQSLREHRVARGLAPEDVARAVGLGLPAYLRMEESDDWRGTDRQSAQLADVLGLTLPDFVTVTGREEKLADLLTSAVTTRWQGCVRPIAKLAPLDRRVLENVLQVLHQDYQGRMAATLSWGGGAPDSSAGGRDFLDRIVDHFWTAVERHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD59</accession>
    <name>Q9RD59_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0623</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624934.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027254.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0623"/>
    <dbReference type="GeneID" id="1096046"/>
    <dbReference type="KEGG" id="sco:SCO0623"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.605"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_2_4_11"/>
    <dbReference type="InParanoid" id="Q9RD59"/>
    <dbReference type="OMA" id="MFGGTVF"/>
    <dbReference type="PhylomeDB" id="Q9RD59"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB62752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="539" mass="55676" checksum="4C4FCDBB0FB9F4F3" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDB3</accession>
    <name>Q9RDB3_STRCO</name>
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        <recommendedName>
            <fullName evidence="2">Glucanase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2838</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011028610.1">
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    </dbReference>
    <dbReference type="SMR" id="Q9RDB3"/>
    <dbReference type="STRING" id="100226.SCO2838"/>
    <dbReference type="CAZy" id="GH6">
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    </dbReference>
    <dbReference type="GeneID" id="1098272"/>
    <dbReference type="KEGG" id="sco:SCO2838"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2897"/>
    <dbReference type="eggNOG" id="COG5297">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015488_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RDB3"/>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51989"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="34996" checksum="A616E21D0E3EA277" modified="2000-05-01" version="1">MSRRRAASAAALGAAALLLAGCSSSGDGDDKAAGAGITQQPKETGPFWVNPDGNAAQQVASLADAGKKDQAEEIRKIAQQPTGEWISPENPEEQARGFTEAADEAGRTALLVLYNIPHRDCGQYSEGGAADGDAYRSFVDGVAKGIGDRAATVVLEPDAVLHLVDGCTPQEFHEERYDLLKGAVAKLGALKNTKVYLDAGNAGWGHPDQIFDPLKRAGVDQADGFAVNVSNFYTTEDSIAYGKQLSAKVGGKPFVIDTSRNGNGPYTEGAPDERWCNPPGRALGETPTTKTADPLVDAYLWVKRPGESDGECKGGPKAGEWYPEYALKLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDG3</accession>
    <name>Q9RDG3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2765</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626996.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2765"/>
    <dbReference type="GeneID" id="1098199"/>
    <dbReference type="KEGG" id="sco:SCO2765"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2822"/>
    <dbReference type="eggNOG" id="ENOG5030QMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2013993_0_0_11"/>
    <dbReference type="OMA" id="MPEQNES"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="123" mass="13448" checksum="ECA5E6DD1505456C" modified="2000-05-01" version="1">MPEQNESGHKLAGRLYATMRVLKSLTEPSGPKPVGDEELAGQDSPRERVQALKLDLFNDLVATLQKGRHAKAVGEMFRAMPALVPRQSAAFDKNLGKRGLAEFNAGHRAQLAELKEAYPELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="158" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ4</accession>
    <name>Q9RDJ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO2731</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626963.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028547.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2731"/>
    <dbReference type="GeneID" id="1098165"/>
    <dbReference type="KEGG" id="sco:SCO2731"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2787"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_11"/>
    <dbReference type="InParanoid" id="Q9RDJ4"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="PhylomeDB" id="Q9RDJ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB66270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="760" mass="78287" checksum="DA0E1BA6304EF7FF" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDK7</accession>
    <name>NADD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber>2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName>NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nadD</name>
        <name type="ordered locus">SCO2579</name>
        <name type="ORF">SCC123.17c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NadD family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB66257" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.7.18"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66257.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626817.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RDK7"/>
    <dbReference type="SMR" id="Q9RDK7"/>
    <dbReference type="STRING" id="100226.SCO2579"/>
    <dbReference type="GeneID" id="1098013"/>
    <dbReference type="KEGG" id="sco:SCO2579"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2624"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RDK7"/>
    <dbReference type="PhylomeDB" id="Q9RDK7"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000181451" description="Probable nicotinate-nucleotide adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="188" mass="20581" checksum="21B78DDC6DBA3D7B" modified="2000-12-01" version="2">MGGTFDPIHHGHLVAASEVAAQFQLDEVVFVPTGQPWQKSHRAVSAAEDRYLMTVVATVENPQFSVSRIDIDRGGPTYTVDTLRDLRALNPDADLFFITGADALAQILTWRDSEELFSLAHFIGVTRPGHTLTDAGLPKGGVSLVEVPALAISSTDCRARVAKGDPVWYLVPDGVVRYIDKRHLYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDR4</accession>
    <name>Q9RDR4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626502.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028227.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2253"/>
    <dbReference type="GeneID" id="1097686"/>
    <dbReference type="KEGG" id="sco:SCO2253"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2290"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_0_11"/>
    <dbReference type="OMA" id="LRYGMIR"/>
    <dbReference type="PhylomeDB" id="Q9RDR4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="284" mass="31716" checksum="F86866C2C5D96AAD" modified="2000-05-01" version="1">MSVNGEADEPGWEVDPDDEWGVAVLTTVGRQLKLRREAVGLRAGDFGVAVGYGEDLVYKVEGGKRIPRREYLEKADQVLDAGGLIAAAWEDVKRVRYPKQVRELAKLEATAVEVSLYANHNIHGLLQTEEHMRSLFDTWLPAYTEEETESMVAARLARRSVFERSPAPTLSFVQEEATLRRPVGGRMVWRGQLERLLELGELRSVSIQVMPTDCEEHFGTGGLIEVLKFPDGTAVGRSEGAFNGRPVSDPKQLRILELRYGMIRAQALTPRESRAVIEQMLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI41</accession>
    <name>Q9RI41_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37036">
        <property type="entry name" value="T37036"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026925.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0207"/>
    <dbReference type="GeneID" id="1095631"/>
    <dbReference type="KEGG" id="sco:SCO0207"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.178"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_9_5_11"/>
    <dbReference type="InParanoid" id="Q9RI41"/>
    <dbReference type="OMA" id="WAMDEAR"/>
    <dbReference type="PhylomeDB" id="Q9RI41"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21506" checksum="AB5E056DE00D57DF" modified="2000-05-01" version="1">MEYDIAVGIDRSPASLAAAHWAAHEARRRGSGITLVHVWHRRARPTPYLRVGGTERAWAERTLEEAVRSVRSAHPGLRITERLVCDATVTALVTAADDAEMLVLGSPGPGPVGGFVTGSVSQRVVARADHPVVLVRAGRSAADEHLPAADGLAPEEIPETPYRDVVLGLRVDRPCDEVLDFAFEAARRRGSGPTCPRAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIW3</accession>
    <name>Q9RIW3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0151</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624488.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026886.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095575"/>
    <dbReference type="KEGG" id="sco:SCO0151"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.127"/>
    <dbReference type="eggNOG" id="ENOG5031QKH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2144341_0_0_11"/>
    <dbReference type="OMA" id="PWHGPPH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB58314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="112" mass="11713" checksum="193BA697D23BE47A" modified="2000-05-01" version="1">MSLGPQPWYEPPKRDDPAAGERPPPEPGQDVGSEAARLAVGLRLGLRIAAVWLLYALSAALVPAAYGTRVAGPVSLGVILAAVPLAVGVHALVVYGRRLDRLGSGPDARRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIW6</accession>
    <name>Q9RIW6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0148</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624485.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978728.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0148"/>
    <dbReference type="GeneID" id="1095572"/>
    <dbReference type="KEGG" id="sco:SCO0148"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.125"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_31_8_11"/>
    <dbReference type="InParanoid" id="Q9RIW6"/>
    <dbReference type="OMA" id="CRYLDCQ"/>
    <dbReference type="PhylomeDB" id="Q9RIW6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="8910" checksum="AFAF8C669EC2D551" modified="2000-05-01" version="1">MPIVVDIDVMLARRKMSVGELAERIGITPANLAVLKNGRAKAVRFTTLAALCEVLDCQPGDLLRWEAERLADEATPAERHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ50</accession>
    <name>SYY_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">SCO1818</name>
        <name type="ORF">SCI8.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626086.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027993.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ50"/>
    <dbReference type="SMR" id="Q9RJ50"/>
    <dbReference type="STRING" id="100226.SCO1818"/>
    <dbReference type="GeneID" id="1097252"/>
    <dbReference type="KEGG" id="sco:SCO1818"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1839"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_11"/>
    <dbReference type="InParanoid" id="Q9RJ50"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="PhylomeDB" id="Q9RJ50"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000234800" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <sequence length="422" mass="46324" checksum="9CFCD37F6C46BB14" modified="2000-05-01" version="1">MTDIVDELKWRGLFAQSTDEDALRKALADGPVTFYCGFDPTAPSLHVGHLVQVLTVRRLQQAGHRPLALVGGATGQIGDPRPTAERTLNSPETVAGWVERLRGQIEPFLSFEGENAAVMVNNLDWTEGLSAIEFLRDIGKHFRVNKMLTKDSVARRLESSEGISYTEFSYQLLQAMDFLQLYRRYGCTMQQGGSDQWGNLTAGLDLLHRLEPDASVHAYATPLMTKADGTKFGKTEGGAVWLDPEMTTPYAFYQFWLNVDDRDISTYMRILSFRSRAELEELERQTEERPQARAAQRALAEELTTLVHGAGQTAAVIAASKALFGQGELAELDEATLAAALSELPHVRVAEPAPVVDLFAEVGLVASKSAARRTVKEGGAYVNNAKVTGEDAVPAKEDLLHGRWLVLRRGKKNLAAVEITGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJE2</accession>
    <name>Q9RJE2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0750</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61543.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625053.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978111.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0750"/>
    <dbReference type="GeneID" id="1096173"/>
    <dbReference type="KEGG" id="sco:SCO0750"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.740"/>
    <dbReference type="HOGENOM" id="CLU_210464_0_0_11"/>
    <dbReference type="OMA" id="RRPETGW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61543.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="59" mass="6473" checksum="006C10BD41620B54" modified="2000-05-01" version="1">MTTDTDGKPAVRRLETGWSKARRLRSRGVMRTCVPAVEDGSTVRAPQSGQESNIVRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJF7</accession>
    <name>Q9RJF7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624796.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978389.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0477"/>
    <dbReference type="GeneID" id="1095900"/>
    <dbReference type="KEGG" id="sco:SCO0477"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.455"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_0_11"/>
    <dbReference type="InParanoid" id="Q9RJF7"/>
    <dbReference type="OMA" id="GFVKKHD"/>
    <dbReference type="PhylomeDB" id="Q9RJF7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="14098" checksum="E2EF6CE4955DA92B" modified="2000-05-01" version="1">MKINLTSVFVDDQAHALRFYTETLGFLKKHDVPVGAGGDRWLTVVSPEAPDGTELLLEPSGHPAVAPYRTALAQDGIPAASFAVDDVRAEHDRLRSLGVHFTQEPMEMGAVTTAVLDDTCGNLIQIMQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJI1</accession>
    <name>Q9RJI1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB57410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624871.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027204.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0558"/>
    <dbReference type="GeneID" id="1095981"/>
    <dbReference type="KEGG" id="sco:SCO0558"/>
    <dbReference type="eggNOG" id="ENOG50348EP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171137_0_0_11"/>
    <dbReference type="OMA" id="FMRGRVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB57410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="88" mass="9665" checksum="A61F4347CD5B043F" modified="2000-05-01" version="1">MDEVEFMRGRVYGADHDNPGPRAGRVYAHLVGGPLDGLLLDVTDLTEQERARGVTLATEIGRYGPGGHSAYTPRPGDTRRFDWRGDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJX7</accession>
    <name>Q9RJX7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625483.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977638.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096616"/>
    <dbReference type="KEGG" id="sco:SCO1193"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1192"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_3_11"/>
    <dbReference type="OMA" id="HELLMTM"/>
    <dbReference type="PhylomeDB" id="Q9RJX7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="189" mass="20688" checksum="2EC75D53C59259B8" modified="2000-05-01" version="1">MAQRRRGAALEKALLDAAWGELAERGYARFTMDGVVRRAGTSPPVLYRRWAHRDELARAAVAHVLEEARVDTPDTGTLRGDLLALMREIGTANAQLVILMYAHLAGYCQETGTSPGELLDAARGKSADALAEVYDRAVARGEARPERLTGRVRSLPFDLLRQEILATLAPVPEDVVEEIVDTIFLPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKF2</accession>
    <name>Q9RKF2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3485</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029024.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3485"/>
    <dbReference type="GeneID" id="1098922"/>
    <dbReference type="KEGG" id="sco:SCO3485"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3544"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RKF2"/>
    <dbReference type="OMA" id="ALERHWV"/>
    <dbReference type="PhylomeDB" id="Q9RKF2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="349" mass="37085" checksum="66615B1AE3D06109" modified="2000-05-01" version="1">MTSEAGAGQAKALPARARLVDVAKRAGVTKSVVSRILNDDTTLRIRPETRERVLAVAAELGYRPNVTARALSVSRTRAFALLIPDLSNSVYAAVTRGAFRRARDHGYVLLIAEDAAGDDDAAYAELVTAGRVDGLLVASSRPEHPLVERLLADRGGLAHVFLNREVQGSNRNVGMDMQGASALVVDHLHDRGHRHIGMVTGPLDLAPARSRLDGFQGRLRELGLDDTAHFAGTFSEAGGCAAAHGLLDARPELTALYASTFPQAVGVMKAVRDRGWKVPADVSLIAYDDLPMAEFLDPPLTTLAMPLATLGAAAVDALVDQIEGRVIGSRQVLGGYEIVERASVAVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKH7</accession>
    <name>Q9RKH7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC-transporter transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3455</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627659.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028996.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3455"/>
    <dbReference type="GeneID" id="1098892"/>
    <dbReference type="KEGG" id="sco:SCO3455"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3515"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_4_11"/>
    <dbReference type="OMA" id="GNAWPAT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="29199" checksum="9606DEAAC225D1C4" modified="2000-05-01" version="1">MPPRWRGLLLTAPALAVVAFAGGALLLAARGSLADGLGRGWSLSAYAGLLQDPAFADSLLLSLKIATLSTVMSAALALAVVGAVSGSRRGRAALETAARATLAVPHLLAAAAFALLLSGSGLISRLTHAAGWTDGPADFPALVAGTTPSAVVLTYVWKEAPFVTIMLLAAYTPAVRDLENAIRTLGAGRMRRMRHVTLPLLAPALTEACLLVFAFTFAAYEAPALLGATVPRALPVEAVELYRSVELADRPAALALAVVIGMVIALAALAAAAISRRLLLARTGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ0</accession>
    <name>Y2278_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein SCO2278</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2278</name>
        <name type="ORF">SCC75A.24</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB61724" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61724.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50587">
        <property type="entry name" value="T50587"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626526.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028246.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKQ0"/>
    <dbReference type="STRING" id="100226.SCO2278"/>
    <dbReference type="GeneID" id="1097711"/>
    <dbReference type="KEGG" id="sco:SCO2278"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2315"/>
    <dbReference type="HOGENOM" id="CLU_067337_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000253347" description="Uncharacterized lipoprotein SCO2278">
        <location>
            <begin position="33"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="329" mass="35281" checksum="5BCDA1FF6809C2CE" modified="2006-10-17" version="2" precursor="true">MSQDRGPRRPRRLEKCALISASATVLSLTASGCVVVHGEREVLPSATRAEAAKALERFTTAYNKADKAYDASLDADHTTGALAAIDSARLKAGAANHPDGNPAHEPLELTDAKFTIPKKAGWPRWFVADTKANKGGTARWLLVFTRDGLEETWEAAYLTLVAPGKVPEFKTDQDGWAEAVPANATDVSVPPAGLSKDYTTYLQDGGKTFADGVHTSSWRALREKRSTRPGLVTQYIDEPLTNGDYAPLALRTEDGGALVFFTSRHFEKQTAARGTSVPTPNKDVLALTDGEIKQSLTMEFVSNEVALDPADGQVSVLGRVQGLTSGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKR2</accession>
    <name>Q9RKR2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ordered locus">SCO2266</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50575">
        <property type="entry name" value="T50575"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626514.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976546.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2266"/>
    <dbReference type="MEROPS" id="M24.A06"/>
    <dbReference type="GeneID" id="1097699"/>
    <dbReference type="KEGG" id="sco:SCO2266"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2303"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKR2"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="PhylomeDB" id="Q9RKR2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="31143" checksum="94E1801801C03D32" modified="2000-05-01" version="1">MSGQSLLVPGELSPTRSVPGNIRRPEYVGKPAPTPYTGPEVQTPETVEAMRVAGRIAARAMEEAAKHIAPGVTTDALDRVAHEYMCDHGAYPSTLGYRGYPKSLCSSVNEVICHGIPDSTVLRDGDIVNLDVTAYIGGVHGDNNATYLVGEVDEESRLLVERTRESLTRAIKAVKPGRQINIIGRVIESYAKRFGYGVVRDFTGHGINTSFHSGLIVPHYDSPHATTVIQPGMTFTIEPMLTLGTHEYDMWDDGWTVVTKDRRRTAQFEHTLVVTDSGAEILTLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKU4</accession>
    <name>ALLC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable allantoicase</fullName>
            <ecNumber evidence="1">3.5.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alc</name>
        <name type="ordered locus">SCO6248</name>
        <name type="ORF">SCAH10.13</name>
        <name type="ORF">STAH10.13</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>allantoate + H2O = (S)-ureidoglycolate + urea</text>
            <dbReference type="Rhea" id="RHEA:11016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="3.5.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.4" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630348.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030765.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKU4"/>
    <dbReference type="SMR" id="Q9RKU4"/>
    <dbReference type="STRING" id="100226.SCO6248"/>
    <dbReference type="GeneID" id="1101689"/>
    <dbReference type="KEGG" id="sco:SCO6248"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6362"/>
    <dbReference type="eggNOG" id="COG4266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038797_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKU4"/>
    <dbReference type="OMA" id="MDDGWET"/>
    <dbReference type="PhylomeDB" id="Q9RKU4"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="PTHR12045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0659">Purine metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205929" description="Probable allantoicase">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00813"/>
        </source>
    </evidence>
    <sequence length="376" mass="41208" checksum="2247C0B2300C4A29" modified="2000-05-01" version="1">MTAQQNTSLASFTGDAQPYGGGDPYADYRTADLPFTQYANLADRQLGAGVVAANDEFFAQRENLLVPEPAEFDPEHFGHKGKVMDGWETRRRRGVSAEQPWPTEEDHDWALIRLGAPGVIRGIVVDTAHFRGNYPQAVSVEGASVAGSPSPEELLADDVKWTTLVPRTPVGGHAANGFAVSAEQRFTHLRLKQHPDGGIARLRVYGEVVADPAWLAALGTFDVVALENGGQVEDASNLFYSPATNTIQPGRSRKMDDGWETRRRRDKGNDWIQYRLVDRSQIRAIEIDTAYLKGNSAGWASVSVKDGEAGEWREVLPRTRMQPDTNHRFVLPEAAVGTHARVDIFPDGGISRLRLFGSLTEDGAARLAARHQELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL02</accession>
    <name>Q9RL02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0316</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624643.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027011.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0316"/>
    <dbReference type="GeneID" id="1095740"/>
    <dbReference type="KEGG" id="sco:SCO0316"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.291"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_7_0_11"/>
    <dbReference type="InParanoid" id="Q9RL02"/>
    <dbReference type="OMA" id="AYSSGEQ"/>
    <dbReference type="PhylomeDB" id="Q9RL02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="308"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB55673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="555" mass="58364" checksum="7484997C8BA6BE0A" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1P9</accession>
    <name>Q9S1P9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0242</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37157">
        <property type="entry name" value="T37157"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624574.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026951.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0242"/>
    <dbReference type="GeneID" id="1095666"/>
    <dbReference type="KEGG" id="sco:SCO0242"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.215"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_1_11"/>
    <dbReference type="OMA" id="MAYVRGP"/>
    <dbReference type="PhylomeDB" id="Q9S1P9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="15887" checksum="FB43D48068E7E371" modified="2000-05-01" version="1">MTFIRRFDHVGITVSDLEAVTAFFVSLGLEADRKMAVEGEFLDTVIGMTDARTEIVMLRPPGGGTTLELSSFTRPDHLPGSPAAPANELGLRNVAFEVHDLQAAVDHAVVDGYGLVGGIGEYEGEWRMAYVRGPEGIIVSLAERIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U2</accession>
    <name>Q9S2U2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ordered locus">SCO2043</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35072">
        <property type="entry name" value="T35072"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626303.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S2U2"/>
    <dbReference type="STRING" id="100226.SCO2043"/>
    <dbReference type="GeneID" id="1097477"/>
    <dbReference type="KEGG" id="sco:SCO2043"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2074"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_11"/>
    <dbReference type="InParanoid" id="Q9S2U2"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="PhylomeDB" id="Q9S2U2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="235"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAB51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="502" mass="54164" checksum="0BCD21DDE8983436" modified="2000-05-01" version="1">MDVTHDMDLDTFRKLAADRRVIPVSRKLLADGDTPVALYRKLAASRPGTFLLESAENGRSWSRYSFVGVRSAATLTEKDGQAHWQGTPPVGVPTDGDPLAALRATVEALHTPRDLAHDLGLPPFTGGMVGYLGYDIVRRLEKVGPGERDDLKLPELTMLLTSDLAVMDHWEGSVLLIANAINHNDLETGVDEAYADAIARLDVMEADLTRAVAQPPAALPPSELPEYTALWGGPDFQDAVEDIKERIRAGEAFQVVPSQRFETPCTASALDVYRVLRATNPSPYMYLLRLDGFDVVGSSPEALVKVEDGRAMVHPIAGTRPRGATPREDQSLADELLADPKERAEHLMLVDLGRNDLGRVCEPGSVEVVDFMSVERYSHVMHIVSTVTGRVAPGRTAFDVLTACFPAGTLSGAPKPRALQIIDELEPSRRGLYGGCVGYLDFAGDSDTAIAIRTALLRDGTAYVQAGAGVVADSDPVAEDTECRNKAAAVLRAVHTANRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S6T6</accession>
    <name>Q9S6T6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3224</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36316">
        <property type="entry name" value="T36316"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627438.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975592.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3224"/>
    <dbReference type="GeneID" id="1098658"/>
    <dbReference type="KEGG" id="sco:SCO3224"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3286"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9S6T6"/>
    <dbReference type="OMA" id="IYYKRQD"/>
    <dbReference type="PhylomeDB" id="Q9S6T6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB38595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="34090" checksum="51B8B7791DD61512" modified="2000-05-01" version="1">MITLDRLTKRYGDKTAVSDLSFEINPGKVTGFLGPNGAGKSTTMRMIVGLDAPTSGRALVGGKRYEELRHPLREVGALLDARAGHPGRSARHHLLGLARSNGIPASRVGEVLQTVGLSEVANKRIGSFSLGMGQRLGIAAALLGDPKVLLFDEPVNGLDPDGVRWVRELMRSLAAEGRTIFVSSHLMSEMQETADHLLVIGRGKIIADAPIEEVIAGSSLTAVRVRTPQPDVLRRELLEFGLRVEPNADSAPDELLVVGGTLEEIGDLAFHHRVPIHELSMRKASLEQAYMELTAASVEYGSPALSQVTEVPDHQKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Q6</accession>
    <name>IDI_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="1">IPP isomerase</shortName>
            <ecNumber evidence="1">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">idi</name>
        <name type="ordered locus">SCO6750</name>
        <name type="ORF">SC5F2A.33c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35275">
        <property type="entry name" value="T35275"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630823.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972247.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X7Q6"/>
    <dbReference type="SMR" id="Q9X7Q6"/>
    <dbReference type="STRING" id="100226.SCO6750"/>
    <dbReference type="GeneID" id="1102189"/>
    <dbReference type="KEGG" id="sco:SCO6750"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6857"/>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_2_1_11"/>
    <dbReference type="InParanoid" id="Q9X7Q6"/>
    <dbReference type="OMA" id="VEQEYNH"/>
    <dbReference type="PhylomeDB" id="Q9X7Q6"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205269" description="Isopentenyl-diphosphate Delta-isomerase">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <sequence length="197" mass="21193" checksum="2F0D98384C02AD42" modified="1999-11-01" version="1">MPITPATATPSSSNGTAEAILLELVDENGVTIGTAEKLSAHQPPGRLHRAFSVFLFDERGRLLIQQRALGKYHSPGVWSNTCCGHPYPGEAPFAAAARRTFEELGVSPSLLAEAGTVRYNHPDPASGLVEQEYNHLFVGLVQAELRPDPEEVAGTAFVSPAELTERHAQDTFSAWFMTVLDAARPAVRELTGTSAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7X3</accession>
    <name>Q9X7X3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6778</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35418">
        <property type="entry name" value="T35418"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630850.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031175.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6778"/>
    <dbReference type="GeneID" id="1102217"/>
    <dbReference type="KEGG" id="sco:SCO6778"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6887"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_27_0_11"/>
    <dbReference type="InParanoid" id="Q9X7X3"/>
    <dbReference type="OMA" id="TLYVYFD"/>
    <dbReference type="PhylomeDB" id="Q9X7X3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB39711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="25281" checksum="1088E782D091B0EE" modified="1999-11-01" version="1">MSEQLNADRPKTRRKEPAGRGSASEQKILAAAKELFLADRYDGVNLERIAARAGVSRQTVYNRFGSKETVFREMVRHHWSAFAGPGRDIAECGPDASAEEVLRGFAQSLQRFATETDQIRFAQLVVTESARLPWIADEFYRLGKGPVVVTFADCLDSLVRRGLLRCPDTHLAARQFTGLVQEFLVWPRVMAFEEEVAGQAPPEVVIEEAVLTFLARYAPAADGPGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X894</accession>
    <name>Q9X894_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3302</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36122">
        <property type="entry name" value="T36122"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028895.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3302"/>
    <dbReference type="GeneID" id="1098736"/>
    <dbReference type="KEGG" id="sco:SCO3302"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3363"/>
    <dbReference type="eggNOG" id="ENOG5033RYZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031195_0_0_11"/>
    <dbReference type="OMA" id="NPWLHAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="433" mass="47945" checksum="C6818575F2AAC9F3" modified="1999-11-01" version="1">MAAPLQLTRTHRVLIGLVVFGAVIIAGIGFAGSYAAVRELALKKGFGNFSYVFPIGIDAGICVLLALDLLLTWIRIPFPLLRQTAWLLTAATIAFNGAAAWPDPLGVGMHGVIPILFVVSVEAARHAIGRIADITADKHMEGVRLTRWLLSPVPTFLLWRRMKLWELRSYEQVIKLEQERLVYRARLRSRFGRAWRRKAPVESLMPLRLARYGVPLAQTGPAGLAAAGIEPALLPPVPRQLQETDPQAPAGEQRAELVKGPEADRPRPAEPSGPEGPSPQGAGEEDGPEQSPWFNTRQVAYQGGYDPSYDPGEQYAQWYEEQQQADEYRDQYEEEPPLQEPSPEETGSFPIPVVPGRTRELGEGAGPAEPAPTEEDYYTVFRKSIDGSYPTVAQFRGDVEATFGVPLAPREADRMVKAFSERHMRELQEEHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X896</accession>
    <name>Q9X896_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3520</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36103">
        <property type="entry name" value="T36103"/>
    </dbReference>
    <dbReference type="PIR" id="T36161">
        <property type="entry name" value="T36161"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627720.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029056.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3520"/>
    <dbReference type="GeneID" id="1098956"/>
    <dbReference type="KEGG" id="sco:SCO3520"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3577"/>
    <dbReference type="eggNOG" id="ENOG5031GTG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093800_0_0_11"/>
    <dbReference type="OMA" id="DFHPVPD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="26646" checksum="1A8260E15B32322D" modified="1999-11-01" version="1">MPSHYDVLPDLAFGHHPVHGIVAANPKNLAASTWMLKGFDFHPVPDQPTLYALADQNRDGHGRTSRAIELLRKAGYQVDVDAALDPAPAPETAQVRDRGPLGEPDVAFADHPQLGIVAALDDRVSGLSGLALVEDGWRHNSSLDIYTLPATTDRVEALGKVADATVALHRSGLQVAVQPCLAQEVTARPRPAGTPTAGRERGRGPARASPLSAAALAASPARAGIPGRAPVPASAVITAAVRPVDPRIAYSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8M9</accession>
    <name>Q9X8M9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative large ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3372</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36383">
        <property type="entry name" value="T36383"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627580.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028942.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3372"/>
    <dbReference type="GeneID" id="1098809"/>
    <dbReference type="KEGG" id="sco:SCO3372"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3435"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009117_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8M9"/>
    <dbReference type="OMA" id="YWLIRNN"/>
    <dbReference type="PhylomeDB" id="Q9X8M9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="267"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109532" checksum="A209A5785CA94400" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8P4</accession>
    <name>Q9X8P4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36517">
        <property type="entry name" value="T36517"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975312.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3627"/>
    <dbReference type="GeneID" id="1099063"/>
    <dbReference type="KEGG" id="sco:SCO3627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3686"/>
    <dbReference type="eggNOG" id="ENOG50307YJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2829439_0_0_11"/>
    <dbReference type="OMA" id="CPVHLGP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="66" mass="7069" checksum="DDE71B833F5B6E95" modified="1999-11-01" version="1">MTDRYSAASCQGPYGGENGPEDCGDPVRFEVARHLRAPLRVCPVHLGPSLLLATGVLWPPGIVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8R8</accession>
    <name>Q9X8R8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3651</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36541">
        <property type="entry name" value="T36541"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627845.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029144.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3651"/>
    <dbReference type="GeneID" id="1099087"/>
    <dbReference type="KEGG" id="sco:SCO3651"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3711"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052486_3_0_11"/>
    <dbReference type="InParanoid" id="Q9X8R8"/>
    <dbReference type="OMA" id="PGPWDDC"/>
    <dbReference type="PhylomeDB" id="Q9X8R8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB42038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="28865" checksum="A099021ED6352AAE" modified="1999-11-01" version="1">MSNEPITLTAGDAEATVLPGNGGRIGGLRVGGTELLRQGERYGCFPMVPWCGRIRDGRFSDGAVVHQMPLNSPPHAIHGTARDAAWRTARVTADEAVITYDLVDPWPYPGRVTQVVALAEDRLTLSMSVETYESSFPAQIGWHPWFNRTLDGTGVEIAFDPAWQEERGDDHLPTGNRVEPKPGPWDDCFGMPDGVDVTLTWPGLLELKVTSREQWAVVYDEQEAAVCVEPQTGPPNGLNTLPRLVTPLEPLEATTTWSWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8S5</accession>
    <name>Q9X8S5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3658</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36548">
        <property type="entry name" value="T36548"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627852.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029150.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3658"/>
    <dbReference type="GeneID" id="1099094"/>
    <dbReference type="KEGG" id="sco:SCO3658"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3718"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_0_11"/>
    <dbReference type="InParanoid" id="Q9X8S5"/>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="PhylomeDB" id="Q9X8S5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="396" mass="42786" checksum="727DBF14C347EBDE" modified="1999-11-01" version="1">MTSMSSSARPLLNRRLAEFGTTIFAEMSALAVRTGAINLGQGFPDTDGPEEVREAAVRALRDGRGNQYPPGPGVPELRAAVAGHQQRRYGLSYDPDTEVLVTAGATEAIAAALLALLEPGDEVVALEPYYDSYAACIAMAGGTRVPVTLRPHEGTFRLDLDELRDAVTDRTRLLLLNTPHNPTGTVLTRDELAAIAELAVERDLLVVTDEVYEHLVFGTAEHIPLASFPGMRERTVTIGSAGKTFSFTGWKVGWVTAAPALLTAVRSAKQYLTYVASGPFQYAVAEALALPESYFAAYRQDMEAKRDLLAAGLAEAGFGVYRPAGTYFVTTDIRPLGERDGFAFCRSLPERAGVVAVPNAVFYNHREEGAPFVRFAFCKRLPVLEEAVGRLKTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8X9</accession>
    <name>Q9X8X9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36632">
        <property type="entry name" value="T36632"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627889.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029171.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3697"/>
    <dbReference type="GeneID" id="1099133"/>
    <dbReference type="KEGG" id="sco:SCO3697"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616653_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8X9"/>
    <dbReference type="OMA" id="QASHRWA"/>
    <dbReference type="PhylomeDB" id="Q9X8X9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="406" mass="42665" checksum="BCEA511A0288E3A0" modified="1999-11-01" version="1">MTQHTDVVVIGGGQAGLAAGYHLRRQGLDFVVLDARATPGGAWRHAWDSLHLFSPAAFSSLPGRLMPAQPGEEYPEAGHVVAYLSDYEKRYGLPVRRPVQVTGVHDEGRLLRVETDSGTWHARAVISATGTWWRPFLPAVPGRGDFAGRQLHTVSYRGPQDFAGRRVIVVGGGNSGAQIAADLAYDTELTWVTRRPPRYLADDIDGRALFDAATALPHSRLRSSGGTPIAPSTPAAPAPQASHRWATSSPYRRCARPGTPGGSRRPRCSSAWTATVPSGPTARGRRSTRSSGAPASARRSRTWRPSACAAGAGTSPRWARRPRTSHACTSSATATGPAPPPPPSSASGVRPATRPALSPNSSTRQGDPRAIGRKGADTGMTTGPAGAGYRTVSSCPIAASTDGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9T9</accession>
    <name>Q9X9T9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3929</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37182">
        <property type="entry name" value="T37182"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029316.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3929"/>
    <dbReference type="GeneID" id="1099365"/>
    <dbReference type="KEGG" id="sco:SCO3929"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055820_0_0_11"/>
    <dbReference type="OMA" id="DFYAMDC"/>
    <dbReference type="PhylomeDB" id="Q9X9T9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB46967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="450" mass="50055" checksum="20BB5634FA05B143" modified="1999-11-01" version="1">MTEAAPTPAALPPHVLERADVRSAIANHDFGEVFRLAKLHGHISFAKIAEAVGYKREHIGKMARPETEGKGVRPRITQFHKVLEVIDGLRIPGHLAGVAPRPWELERPATATRTEDPSALIAQGGAGLWDVAEMLRRTEMSDINSAALESIEQGIDQLARAYPYADADYLHERTRSGLHYVTKQLESRMTLRQHQELLVDTGWLFLLNACVQYDRGQREAANLSKAAALRIGEEAGHGEIKAWAWEIEAWFALTQSRWQDMLDAVEAGHIADQTHSVGVQLYAHKARAAARMGDGRLVRDSLDAGRARLDRLPRPDHPEHHFIIDPDKWDFYEMDAYRLLGDDERAATHARSVIRISTGPDGTEISPMRAAEARLTLGVAAARTGEIDEAIGMGTTALEADRKSLPSLLLVADELDKELRSRYPRETATRDFHEQVMAIKRGSANPELPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA14</accession>
    <name>SRTE1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sortase SrtE1</fullName>
            <ecNumber evidence="7">3.4.22.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sortase E1 transpeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srtE1</name>
        <name type="ordered locus">SCO3850</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Mol. Microbiol." volume="83" first="992" last="1005">
            <title>Aerial development in Streptomyces coelicolor requires sortase activity.</title>
            <authorList>
                <person name="Duong A."/>
                <person name="Capstick D.S."/>
                <person name="Di Berardo C."/>
                <person name="Findlay K.C."/>
                <person name="Hesketh A."/>
                <person name="Hong H.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="22296345"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2012.07983.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>POSSIBLE ACTIVE SITE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF VAL-119 AND CYS-320</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="E0167763" last="E0167763">
            <title>Crystal structure of the Streptomyces coelicolor sortase E1 transpeptidase provides insight into the binding mode of the novel class E sorting signal.</title>
            <authorList>
                <person name="Kattke M.D."/>
                <person name="Chan A.H."/>
                <person name="Duong A."/>
                <person name="Sexton D.L."/>
                <person name="Sawaya M.R."/>
                <person name="Cascio D."/>
                <person name="Elliot M.A."/>
                <person name="Clubb R.T."/>
            </authorList>
            <dbReference type="PubMed" id="27936128"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0167763"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 162-352 IN COMPLEX WITH SUBSTRATE ANALOG</scope>
        <scope>FUNCTION</scope>
        <scope>POSSIBLE ACTIVE SITE</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF 82-ARG--LYS-90</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Transpeptidase that anchors surface proteins to the cell wall. Recognizes both Leu-Ala-x-Thr-Gly and Leu-Pro-x-Thr-Gly, with a preference for the former. Unlike the S.aureus sortase it cleaves not only the Thr-Gly motif but also the Ala-X bond; Ala-Glu and Ala-His bonds are better substrates than the Thr-Gly motif in vitro (PubMed:22296345, PubMed:27936128). Among its possible substrates are the chaplins ChpA, ChpB and ChpC; this enzyme is less important for ChpC attachment than is SrtE2. A double knockout mutant of srtE1 and srtE2 shows a developmental defect in aerial hyphae formation more dramatic than that due to chaplin deletion (PubMed:22296345).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>The enzyme catalyzes a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.</text>
            <dbReference type="EC" id="3.4.22.70"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Transcribed independently of the operon's upstream, overlapping gene (SCO3851); transcribed with srtE2 over the first 72 hours of growth. Part of the strE1-srtE2 operon.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The probably cytoplasmic N-terminus cannot be deleted without destabilizing the protein.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">A single srtE1 deletion, has a significant delay in aerial hyphae formation when grown on minimal medium, but no delay on rich medium. Nearly wild-type levels of ChpC are attached to the cell wall. A double srtE1-srtE2 knockout grown on minimal medium has a more severe delay in aerial hyphae formation and does not make spores, on rich medium initiates aerial hyphae formation later than wild-type and does not make spores. In the double mutant no ChpC is attached to the cell wall in liquid medium, on solid minimal medium chpD, chpF (SCO2699), rdlA and nepA are transcribed poorly or not at all (with no change in chpH), while very few spore chains or rodlets are seen on the aerial hyphae.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the bacterial sortase family. Class E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.70" evidence="7"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36719">
        <property type="entry name" value="T36719"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628038.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029270.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDB" id="5CUW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="A=162-352"/>
    </dbReference>
    <dbReference type="PDBsum" id="5CUW"/>
    <dbReference type="AlphaFoldDB" id="Q9XA14"/>
    <dbReference type="SMR" id="Q9XA14"/>
    <dbReference type="STRING" id="100226.SCO3850"/>
    <dbReference type="GeneID" id="1099286"/>
    <dbReference type="KEGG" id="sco:SCO3850"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3921"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045680_5_2_11"/>
    <dbReference type="InParanoid" id="Q9XA14"/>
    <dbReference type="OMA" id="WTNVRAH"/>
    <dbReference type="PhylomeDB" id="Q9XA14"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000445191" description="Sortase SrtE1">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="8">
        <location>
            <begin position="161"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for protein stability" evidence="4">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="site" description="Substrate recognition" evidence="8">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Wild-type function, restores sporulation to double srtE1-srtE2 knockout." evidence="4">
        <location>
            <begin position="82"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No effect, this is not the start codon." evidence="3">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Inactive, does not complement a double srtE1-srtE2 knockout. Significantly reduced in vitro peptide cleavage activity." evidence="3">
        <original>C</original>
        <variation>A</variation>
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="196"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="241"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="22296345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="27936128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="22296345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="27936128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="22296345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="27936128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="10">
        <source>
            <dbReference type="PDB" id="5CUW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="5CUW"/>
        </source>
    </evidence>
    <sequence length="352" mass="37820" checksum="D1825C3F2E580711" modified="1999-11-01" version="1">MTALRPERDSGTAGDQGSSYGQPYGDSGAFGGGRYEESAAGEENRPPLLDDETVALRIPEPPAPRTAAGTGPIGGGPDGGGRAARRKAAKRRHGRRGAPRDQAPEEEAEQAPKAPLSRVEARRQARARKPGAAVVASRAIGEIFITTGVLMLLFVTYQLWWTNVRAHAQANQAASNLQDDWANGKRSPGSFEPGQGFALLHIPKLDVVVPIAEGISSKKVLDRGMVGHYAEDGLKTAMPDAKAGNFGLAGHRNTHGEPFRYINKLEPGDPIVVETQDKYFVYKMASILPVTSPSNVSVLDPVPKQSGFKGPGRYITLTTCTPEFTSKYRMIVWGKMVEERPRSKGKPDALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAA4</accession>
    <name>Q9XAA4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0821</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36434">
        <property type="entry name" value="T36434"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625121.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027374.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0821"/>
    <dbReference type="GeneID" id="1096244"/>
    <dbReference type="KEGG" id="sco:SCO0821"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.813"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_11"/>
    <dbReference type="InParanoid" id="Q9XAA4"/>
    <dbReference type="OMA" id="FKFRGGW"/>
    <dbReference type="PhylomeDB" id="Q9XAA4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006563">
        <property type="term" value="P:L-serine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042866">
        <property type="term" value="P:pyruvate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB48898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="33966" checksum="4E1DE62D340489A7" modified="1999-11-01" version="1">MTTTTPPVTLDDVRSAAARIKGVAHRTPVLRSRTLDALVGAEVHLKCENQQRVGAFKFRGAYNAASRLTPEQLARGIAAYSSGNHAQAVALAARELGTTAVIVMPEDAPPSKRDATAGYGAEIVTYDRYTGDRVAVAEALAADRGLTLIPPYEHPHVIAGQGTAALELVEETGELDALVAPVGGGGLIAGSATAVKALHPGMRVIGVEPEAGDDTRRSLAAGRRVSVPVPRTIADGQALPTPGELTFSLNRRLLDGIVLVSDDEIRDAMRFAFERLKTVLEPSGATPLAALLNGRIDALPRRVGVILSGGNVDAARFAELCGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC1</accession>
    <name>Q9XAC1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO1935</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36007">
        <property type="entry name" value="T36007"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626200.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976883.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1935"/>
    <dbReference type="GeneID" id="1097369"/>
    <dbReference type="KEGG" id="sco:SCO1935"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1962"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAC1"/>
    <dbReference type="OMA" id="WSHHIDE"/>
    <dbReference type="PhylomeDB" id="Q9XAC1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB50760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="695" mass="74961" checksum="42005993544D13A3" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAJ9</accession>
    <name>Q9XAJ9_STRCO</name>
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        <submittedName>
            <fullName evidence="7">Putative Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3603</name>
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    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T35371"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627798.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029115.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3603"/>
    <dbReference type="GeneID" id="1099039"/>
    <dbReference type="KEGG" id="sco:SCO3603"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3661"/>
    <dbReference type="eggNOG" id="COG3263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_9_1_11"/>
    <dbReference type="InParanoid" id="Q9XAJ9"/>
    <dbReference type="OMA" id="WFDEYGE"/>
    <dbReference type="PhylomeDB" id="Q9XAJ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
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        <property type="entry name" value="NhaP"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="23"/>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB45470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="514" mass="53639" checksum="B57D049997E5AA38" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAN4</accession>
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        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6696</name>
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    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T35014"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031112.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6696"/>
    <dbReference type="GeneID" id="1102135"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="893" mass="95372" checksum="543AF9AC78A87408" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z506</accession>
    <name>Q9Z506_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1959</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36032">
        <property type="entry name" value="T36032"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626223.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028067.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1959"/>
    <dbReference type="GeneID" id="1097393"/>
    <dbReference type="KEGG" id="sco:SCO1959"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1985"/>
    <dbReference type="eggNOG" id="ENOG5031RF6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077935_0_0_11"/>
    <dbReference type="OMA" id="PFRRWVE"/>
    <dbReference type="PhylomeDB" id="Q9Z506"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="24670" checksum="BFDA87D7D3C7F6C7" modified="1999-05-01" version="1">MMDHAHDLASVRDATDRLLTAVGKLDNAFVTESSRLPGWSRGHVLAHLARNADALVNVLEGRPMYVSGEARDADIERDAPRPLDAQLADVRESAARFQDVGAAPADWTRTVELRNGVTDSASRVPFRRWAEVELHHVDLGAGYELEDLPAEFTERETDFLAARFAGHPDVPPTRLTDGTRAWTTGRESDAPEVTVTGPPADLLGWLAGRRAGSALTVEGGALPTLPPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z520</accession>
    <name>TPIS_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Triosephosphate isomerase</fullName>
            <shortName evidence="1 3">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1 2">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="synonym">tpi</name>
        <name type="ordered locus">SCO1945</name>
        <name type="ORF">SCC54.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Phys. Chem. Chem. Phys." volume="17" first="20699" last="20714">
            <title>Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins.</title>
            <authorList>
                <person name="Romero-Romero S."/>
                <person name="Costas M."/>
                <person name="Rodriguez-Romero A."/>
                <person name="Alejandro Fernandez-Velasco D."/>
            </authorList>
            <dbReference type="PubMed" id="26206330"/>
            <dbReference type="DOI" id="10.1039/c5cp01599e"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>13 / Type A</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">0.74 mM for G3P</KM>
            <text evidence="2">kcat is 5668 sec(-1) for isomerase activity.</text>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1 2"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36018">
        <property type="entry name" value="T36018"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626209.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976873.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="PDB" id="4Y9A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.29 A"/>
        <property type="chains" value="A/B/C/D=1-258"/>
    </dbReference>
    <dbReference type="PDBsum" id="4Y9A"/>
    <dbReference type="AlphaFoldDB" id="Q9Z520"/>
    <dbReference type="SMR" id="Q9Z520"/>
    <dbReference type="STRING" id="100226.SCO1945"/>
    <dbReference type="PRIDE" id="Q9Z520"/>
    <dbReference type="GeneID" id="1097379"/>
    <dbReference type="KEGG" id="sco:SCO1945"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1972"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_11"/>
    <dbReference type="InParanoid" id="Q9Z520"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="PhylomeDB" id="Q9Z520"/>
    <dbReference type="SABIO-RK" id="Q9Z520"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000090295" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="74"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="86"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="102"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="225"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="246"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="26206330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26206330"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4Y9A"/>
        </source>
    </evidence>
    <sequence length="258" mass="27736" checksum="4454F4DF07D34FFA" modified="1999-05-01" version="1">MTTRTPLMAGNWKMNLNHLEAIAHVQKLAFALADKDYDAVEVAVLAPFTDLRSVQTLVDGDKLKIKYGAQDISAHDGGAYTGEISGPMLAKLKCTYVAVGHSERRQYHAETDEIVNAKVKAAYKHGLTPILCVGEELDVREAGNHVEHTLAQVEGGLKDLAAEQAESVVIAYEPVWAIGTGKVCGADDAQEVCAAIRGKLAELYSQELADKVRIQYGGSVKSGNVAEIMAKPDIDGALVGGASLDSDEFVKIVRFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5B4</accession>
    <name>Q9Z5B4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6188</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34842">
        <property type="entry name" value="T34842"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630291.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030724.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6188"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="GeneID" id="1101629"/>
    <dbReference type="KEGG" id="sco:SCO6188"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6300"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_481377_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z5B4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008713">
        <property type="term" value="F:ADP-heptose-lipopolysaccharide heptosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB36596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="566" mass="56858" checksum="03AE1086CD5F49BD" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBT1</accession>
    <name>Q9ZBT1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6157</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34670">
        <property type="entry name" value="T34670"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630262.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030695.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6157"/>
    <dbReference type="GeneID" id="1101598"/>
    <dbReference type="KEGG" id="sco:SCO6157"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6265"/>
    <dbReference type="eggNOG" id="ENOG502ZR7F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048567_0_0_11"/>
    <dbReference type="OMA" id="AAAWFNW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="354" mass="39304" checksum="586FB11E8E2F9C09" modified="1999-05-01" version="1">MRLTDISLNWLLPGAVLLLGMLAAVAVLARGKRSSGKDAGADDSWERMEERRRRKEALYGTFSYVLLFCCAAVAAALSFHGLVGFGEQNLGLSDGWQYLVPFGLDGAAMFCSVLAVREASHGDAALGSRILVWAFAFAAAWFNWVHAPRGLGHAGAPHFFAGMSLSAAVLFDRALKQTRRAALREQGLVPRPLPQIRMVRWLRAPRETYRAWSLMLLEGVRSLDEAVEEVRDDRRQKEEKKLRRREQERLERAQLKAISRGHGHRGFPGRGGRQVEVEVQQVERGSERAAAEPAISTPEQLPAASRRPSLQPVRSGSEQMSVGTVDLTAEDDTQALPRLDSLERKLKDLEQQFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O31046</accession>
    <accession>Q9L2F5</accession>
    <accession>Q9L2L9</accession>
    <name>LEU1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="1">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuA</name>
        <name type="ordered locus">SCO2528</name>
        <name type="ORF">SCC117.01c</name>
        <name type="ORF">SCC121.31c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Microbiology" volume="145" first="2375" last="2384">
            <title>End-product control of expression of branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2): paradoxical relationships between DNA sequence and regulatory phenotype.</title>
            <authorList>
                <person name="Craster H.L."/>
                <person name="Potter C.A."/>
                <person name="Baumberg S."/>
            </authorList>
            <dbReference type="PubMed" id="10517590"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / D132</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="1"/>
    <dbReference type="EMBL" id="AF026444">
        <property type="protein sequence ID" value="AAB82586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAD55194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733575.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976275.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O31046"/>
    <dbReference type="SMR" id="O31046"/>
    <dbReference type="STRING" id="100226.SCO2528"/>
    <dbReference type="GeneID" id="1097962"/>
    <dbReference type="KEGG" id="sco:SCO2528"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2573"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_11"/>
    <dbReference type="InParanoid" id="O31046"/>
    <dbReference type="OMA" id="FGQGERT"/>
    <dbReference type="PhylomeDB" id="O31046"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000140444" description="2-isopropylmalate synthase">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB82586." evidence="3" ref="1">
        <original>E</original>
        <variation>V</variation>
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB82586." evidence="3" ref="1">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="573" mass="63323" checksum="4CD2AE8646811F74" modified="2002-05-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O69807</accession>
    <name>O69807_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6413</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28683">
        <property type="entry name" value="T28683"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630499.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030899.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6413"/>
    <dbReference type="GeneID" id="1101852"/>
    <dbReference type="KEGG" id="sco:SCO6413"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6513"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017436_2_1_11"/>
    <dbReference type="InParanoid" id="O69807"/>
    <dbReference type="OMA" id="AQLHHVS"/>
    <dbReference type="PhylomeDB" id="O69807"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="306"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="473"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="537" mass="57833" checksum="A9E7D5EFE964ECCE" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O86540</accession>
    <name>O86540_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6606</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29112">
        <property type="entry name" value="T29112"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630683.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031036.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6606"/>
    <dbReference type="GeneID" id="1102045"/>
    <dbReference type="KEGG" id="sco:SCO6606"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6712"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="InParanoid" id="O86540"/>
    <dbReference type="OMA" id="FYGGVAR"/>
    <dbReference type="PhylomeDB" id="O86540"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="32791" checksum="1A8FB3E2E49B1261" modified="1998-11-01" version="1">MMFRPALTQVFSTLEPWVAHELRTESGRMTSLSSGESAAHPDRIDTSRPHPARMYDYFLGGKDNYEVDQRAAEQFMKSAPEVREGVLANRHFMHRAVRHVVAEGGVRQILDVGTGLPTEPNVHQIARSVAPGTRVAYVDNDPIVATHSRALADDPDTAVVLADLRDPRSILEHPEVRAVIDFDRPVALLLVAVVHFVADAQDPAGIVATLRDALPAGSYLVLSHATGDVHEDRREDAAAVYNKATASLNLRSHAAVLDLFGDFSLVEPGLVRVTDWRPEEARRPDAPPIGIYGGVARKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O86639</accession>
    <name>O86639_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5719</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629845.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030411.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5719"/>
    <dbReference type="GeneID" id="1101158"/>
    <dbReference type="KEGG" id="sco:SCO5719"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5810"/>
    <dbReference type="eggNOG" id="ENOG50335W2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076821_0_0_11"/>
    <dbReference type="OMA" id="TGRPQAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="27842" checksum="F2EF84BF1490E3DB" modified="1998-11-01" version="1">MSSLSTRPADGADGRARSEAGTGSSPGARRAPRRFLKGFGLLGPRHGAHTVPAVQLDALALPLGDDGVVIGVDAEGRPAVLGVNRPTPYDVVLIAGLWTAQVIALRAAATGARVAVETGRPQAWVQLVHAMGGGQNGLAVYDVGRVPPQGASAGTPVLVVRDCGMRPPRGRVASGPWQSVLTLLPYLSPVAPRLMRQARLTGVQRVSPDEAAELGRVLALSRTETESLPSLADGMTLWCADRDRQYVMTQPTDGETGLLGTPRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O86704</accession>
    <name>O86704_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6522</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35214">
        <property type="entry name" value="T35214"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630603.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030984.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6522"/>
    <dbReference type="GeneID" id="1101961"/>
    <dbReference type="KEGG" id="sco:SCO6522"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6625"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_7_11"/>
    <dbReference type="OMA" id="AWWAPYA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="100"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="480" mass="49568" checksum="D0E75B24E1F85105" modified="1998-11-01" version="1">MGTGINERRAKHRTDGNGPDGTRARHGQAARHGQAARTARRYGMRRTDPEGLATKPAGHDPAGRHGAGPGAVGHGPVRYGPHFPDDGLPVLPELSAVLAAAAGRARGEPAGGAPALLEAASGYWDRRGLTTDPGHLAAAPGAGALLLALTAALGGDVLVPRPCAAWWAPYARLLGRPVFHVPTPAESGGVPDPYALLETVRRVRAEGGDPRLLVLSVADDPTGTVAPPELLHETVEAATGEGLHLVSDETWRDTLHDPHATVLLSPAEMLPERVTVVTDLAGALLPPAWPAAVARFPASAAGNGLHARVLDVLTALGARVAAPVAAAAGYALGEPEPVTARRAAAVRLHARVAAAAHAAVVASGATARPPQAGRHLYADLGPLREALGAEGVGDAQELEDFLTARLGLPAPGGHRFGDDLPALRVRLATGPLLDAGTDERRAECLLSPDPLELPHVQRALTGLKSVFDGLRDAQRWEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O87852</accession>
    <name>O87852_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6597</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35785">
        <property type="entry name" value="T35785"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031033.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6597"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102036"/>
    <dbReference type="KEGG" id="sco:SCO6597"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6704"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_11"/>
    <dbReference type="InParanoid" id="O87852"/>
    <dbReference type="OMA" id="GWLCTFY"/>
    <dbReference type="PhylomeDB" id="O87852"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="772"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="859" mass="89456" checksum="BD7EAFEAEA4FD59F" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O87856</accession>
    <name>O87856_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted sugar binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6601</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35789">
        <property type="entry name" value="T35789"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630680.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972377.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6601"/>
    <dbReference type="GeneID" id="1102040"/>
    <dbReference type="KEGG" id="sco:SCO6601"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6708"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="InParanoid" id="O87856"/>
    <dbReference type="OMA" id="KLEVVPW"/>
    <dbReference type="PhylomeDB" id="O87856"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174902" evidence="1">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="438" mass="45992" checksum="49B389F5C13B0949" modified="1998-11-01" version="1">MRSIRAAAVGAVTMSLALAATACGGGSSSGGGSNDSPKELTYWASNQGASVEVDKKVLQPELDKFEKETGIKVKLEVVPWSDLLNRILTATTSGQGPDVLNIGNTWSASLQATGALLPWDAKNFEKIGGRDRFVDSALGSTGVEGQDPAAVPLYSMAYALYYNKQMFADAGITKPPATWDELVETGRKISRDGKWGLGAEGSNLSNNIHQVFVLAKQHGADFFTADGKPDFTSDGAVAAVKQYVDLMAQDKVVAPGNAEYAQNQSLSDFAKGKTAMVLWQTASATFKTMGMKDDEWGVAPAPVPSGAPGAGKATNSMVAGINMAVFKNSDNLDGATKFVKFMTSDAEQKLLNKAYGSIPPVKAAQSDPAFNTQATAVLRETLATSAAALPQVPDESQFETAVGTAVKELFADAANGREVTTGSVKEKLAKAQQQMPSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>P0A345</accession>
    <accession>P40172</accession>
    <name>CH10_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">SCO4761</name>
        <name type="ORF">SC6G4.39</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Gene" volume="144" first="97" last="101">
            <title>Characterization of two groEL genes in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Duchene A.M."/>
                <person name="Kieser H.M."/>
                <person name="Hopwood D.A."/>
                <person name="Thompson C.J."/>
                <person name="Mazodier P."/>
            </authorList>
            <dbReference type="PubMed" id="7913076"/>
            <dbReference type="DOI" id="10.1016/0378-1119(94)90210-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / J1501</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="X75206">
        <property type="protein sequence ID" value="CAA53018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S37565">
        <property type="entry name" value="S37565"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628919.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974211.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A345"/>
    <dbReference type="SMR" id="P0A345"/>
    <dbReference type="STRING" id="100226.SCO4761"/>
    <dbReference type="PRIDE" id="P0A345"/>
    <dbReference type="GeneID" id="1100202"/>
    <dbReference type="KEGG" id="sco:SCO4761"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4833"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_11"/>
    <dbReference type="InParanoid" id="P0A345"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="PhylomeDB" id="P0A345"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
        <property type="term" value="P:chaperone cofactor-dependent protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000174858" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="102" mass="10946" checksum="6DF9FA68014AC8CC" modified="2005-03-15" version="1">MTTTSSKVAIKPLEDRIVVQPLDAEQTTASGLVIPDTAKEKPQEGVVLAVGPGRFEDGNRLPLDVSVGDVVLYSKYGGTEVKYNGEEYLVLSARDVLAIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKD9</accession>
    <name>Q7AKD9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6992</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631057.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031363.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6992"/>
    <dbReference type="GeneID" id="1102430"/>
    <dbReference type="KEGG" id="sco:SCO6992"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7094"/>
    <dbReference type="eggNOG" id="COG5549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873710_0_0_11"/>
    <dbReference type="InParanoid" id="Q7AKD9"/>
    <dbReference type="OMA" id="WDDEAVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="39558" checksum="E8366D74CD6068E9" modified="2012-05-16" version="1">MTARYCSLARQPAPVLPPGLAAERVAALVGGQRMWANATVLHYCFLGGDTDASVVPMPGTGRPRRGSWAGTEEQRDVVRDCFREWRDLGIGLGLEEVRDRSEAELRIGFQPGDGSWSAVGKDALGVGLNDRTMNFGWDLTAPGERATALHQIGHALGMLHEHQSPFAGILWDDEAVYAELAGPPNHWSRERTFHNILRKLDGDEANGPVWDPQSIMEYPFSSGLILEPEHYRSGLRPPGTLSAADKEFALRWYPPTGRPGPLVPFRSVPLGLGPGEQADFRVDPPETREYTVGTFGDSDAVVVVFEERDGVPRYFAGQDDGGTPLNATIRARFVKGRRYVVRVRLYSSWGAGETAVMYW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-11-28" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKI9</accession>
    <accession>O88103</accession>
    <name>WHID_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator WhiD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Transcriptional regulator WhiB3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">whiD</name>
        <name type="synonym">wblB</name>
        <name type="synonym">whiB3</name>
        <name type="ordered locus">SCO4767</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="thesis" date="1998" institute="University of East Anglia, United Kingdom">
            <authorList>
                <person name="Palframan W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Microbiology" volume="146" first="333" last="343">
            <title>Multiple paralogous genes related to the Streptomyces coelicolor developmental regulatory gene whiB are present in Streptomyces and other actinomycetes.</title>
            <authorList>
                <person name="Soliveri J.A."/>
                <person name="Gomez J."/>
                <person name="Bishai W.R."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="10708372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Mol. Microbiol." volume="36" first="1265" last="1278">
            <title>Different alleles of the response regulator gene bldM arrest Streptomyces coelicolor development at distinct stages.</title>
            <authorList>
                <person name="Molle V."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10931278"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2000.01977.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="1286" last="1295">
            <title>WhiD and WhiB, homologous proteins required for different stages of sporulation in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Molle V."/>
                <person name="Palframan W.J."/>
                <person name="Findlay K.C."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="10671449"/>
            <dbReference type="DOI" id="10.1128/JB.182.5.1286-1295.2000"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>MUTAGENESIS OF ALA-21</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="J. Biol. Chem." volume="280" first="8309" last="8315">
            <title>Evidence that the Streptomyces developmental protein WhiD, a member of the WhiB family, binds a [4Fe-4S] cluster.</title>
            <authorList>
                <person name="Jakimowicz P."/>
                <person name="Cheesman M.R."/>
                <person name="Bishai W.R."/>
                <person name="Chater K.F."/>
                <person name="Thomson A.J."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="15615709"/>
            <dbReference type="DOI" id="10.1074/jbc.M412622200"/>
        </citation>
        <scope>COFACTOR</scope>
        <scope>SUBUNIT</scope>
        <scope>MUTAGENESIS OF CYS-23; CYS-53; CYS-56 AND CYS-62</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Biochemistry" volume="48" first="12252" last="12264">
            <title>Characterization of [4Fe-4S]-containing and cluster-free forms of Streptomyces WhiD.</title>
            <authorList>
                <person name="Crack J.C."/>
                <person name="den Hengst C.D."/>
                <person name="Jakimowicz P."/>
                <person name="Subramanian S."/>
                <person name="Johnson M.K."/>
                <person name="Buttner M.J."/>
                <person name="Thomson A.J."/>
                <person name="Le Brun N.E."/>
            </authorList>
            <dbReference type="PubMed" id="19954209"/>
            <dbReference type="DOI" id="10.1021/bi901498v"/>
        </citation>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <scope>LACK OF ACTIVITY AS A DISULFIDE REDUCTASE</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="J. Am. Chem. Soc." volume="133" first="1112" last="1121">
            <title>Mechanistic insight into the nitrosylation of the [4Fe-4S] cluster of WhiB-like proteins.</title>
            <authorList>
                <person name="Crack J.C."/>
                <person name="Smith L.J."/>
                <person name="Stapleton M.R."/>
                <person name="Peck J."/>
                <person name="Watmough N.J."/>
                <person name="Buttner M.J."/>
                <person name="Buxton R.S."/>
                <person name="Green J."/>
                <person name="Oganesyan V.S."/>
                <person name="Thomson A.J."/>
                <person name="Le Brun N.E."/>
            </authorList>
            <dbReference type="PubMed" id="21182249"/>
            <dbReference type="DOI" id="10.1021/ja109581t"/>
        </citation>
        <scope>DINITROSYLATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA (By similarity). Plays a positive role in prespore maturation and the initiation of sporulation septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Anaerobically binds 1 [4Fe-4S] cluster per subunit; cluster is lost on exposure to O(2). Cluster is stabilized in the presence of mycothiol. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="5">Optimum pH is 7.0 to 8.0 for 4Fe-4S stability.</text>
        </phDependence>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">The 4Fe-4S form is a monomer; upon oxidation forms a disulfide-bonded homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2 3">Expressed in exponential phase (PubMed:10708372). Expressed from 2 promoters at the onset of sporulation, no longer expressed in mature colonies (PubMed:10671449).</text>
    </comment>
    <comment type="PTM">
        <text>Can be nitrosylated by NO, 8 NO react per cluster. These complexes are quite stable under anaerobic conditions, but degrade slowly aerobically.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Forms white aerial mycelium. Sporulation is reduced, spores are heat sensitive, lyse frequently and highly irregular in size. Septum placement and spore cell wall thickness is irregular.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AJ010601">
        <property type="protein sequence ID" value="CAA09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ239086">
        <property type="protein sequence ID" value="CAB43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35596">
        <property type="entry name" value="T35596"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628925.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974205.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7AKI9"/>
    <dbReference type="SMR" id="Q7AKI9"/>
    <dbReference type="STRING" id="100226.SCO4767"/>
    <dbReference type="GeneID" id="1100208"/>
    <dbReference type="KEGG" id="sco:SCO4767"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4839"/>
    <dbReference type="eggNOG" id="ENOG5032S23">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106245_6_0_11"/>
    <dbReference type="InParanoid" id="Q7AKI9"/>
    <dbReference type="OMA" id="WQLHGAC"/>
    <dbReference type="PhylomeDB" id="Q7AKI9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000420398" description="Transcriptional regulator WhiD">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Wbl-type">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="In whiD16; white on sporulation media, forms defective spores killed at 50 degrees Celsius." evidence="2">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Spores remain white." evidence="4">
        <original>C</original>
        <variation>A</variation>
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Spores remain white." evidence="4">
        <original>C</original>
        <variation>A</variation>
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Spores remain white." evidence="4">
        <original>C</original>
        <variation>A</variation>
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Spores remain white." evidence="4">
        <original>C</original>
        <variation>A</variation>
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="10671449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10708372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15615709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="19954209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="112" mass="11995" checksum="8948745CF2409311" modified="2012-05-16" version="1">MADFSRLPGPNADLWDWQLLAACRGVDSSLFFHPEGERGAARSARENSAKEVCMRCPVRAECAAHALAVREPYGVWGGLTEDEREELMGRARNRLVAATASASAGGEAAGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKJ6</accession>
    <name>Q7AKJ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="PH0260">
        <property type="entry name" value="PH0260"/>
    </dbReference>
    <dbReference type="PIR" id="S61365">
        <property type="entry name" value="S61365"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628592.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974557.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4425"/>
    <dbReference type="GeneID" id="1099865"/>
    <dbReference type="KEGG" id="sco:SCO4425"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4494"/>
    <dbReference type="eggNOG" id="ENOG5031T00">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_201982_0_0_11"/>
    <dbReference type="OMA" id="MDNHMPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="6682" checksum="5BDED75D1B023F99" modified="2012-05-16" version="1">MSDKMKDADATPQDNHMPTPPATEEPVTTLDNHMPSGPANEAITTMDNHMPAPPALDLDGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJJ7</accession>
    <name>Q8CJJ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7525</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAD55406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733736.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031723.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7525"/>
    <dbReference type="GeneID" id="1102963"/>
    <dbReference type="KEGG" id="sco:SCO7525"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7639"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_16_1_11"/>
    <dbReference type="InParanoid" id="Q8CJJ7"/>
    <dbReference type="OMA" id="PRSLKCH"/>
    <dbReference type="PhylomeDB" id="Q8CJJ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="120"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="648"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="764" mass="84222" checksum="67D650EA2F8A4C85" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL9</accession>
    <name>Q8CJL9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6752</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAD55388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35277">
        <property type="entry name" value="T35277"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733714.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031155.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6752"/>
    <dbReference type="GeneID" id="1102191"/>
    <dbReference type="KEGG" id="sco:SCO6752"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6861"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031116_0_0_11"/>
    <dbReference type="OMA" id="FFRAAEY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045985">
        <property type="entry name" value="DUF5941"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF5941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5941" evidence="3">
        <location>
            <begin position="273"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="605" mass="63173" checksum="7527FD4EDFE3CAB1" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJS4</accession>
    <name>Q8CJS4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4940</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2006-08" db="PDB data bank">
            <title>The crystal structure of a tetR-family transcriptional regulator from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Zhang R."/>
                <person name="Xu X."/>
                <person name="Zheng H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) IN COMPLEX WITH CALCIUM</scope>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD55220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733652.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974034.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="PDB" id="2HYJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.19 A"/>
        <property type="chains" value="A=1-200"/>
    </dbReference>
    <dbReference type="PDBsum" id="2HYJ"/>
    <dbReference type="SMR" id="Q8CJS4"/>
    <dbReference type="STRING" id="100226.SCO4940"/>
    <dbReference type="GeneID" id="1100381"/>
    <dbReference type="KEGG" id="sco:SCO4940"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5020"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_4_1_11"/>
    <dbReference type="InParanoid" id="Q8CJS4"/>
    <dbReference type="OMA" id="GCLFTTA"/>
    <dbReference type="PhylomeDB" id="Q8CJS4"/>
    <dbReference type="EvolutionaryTrace" id="Q8CJS4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2HYJ"/>
        </source>
    </evidence>
    <sequence length="200" mass="21737" checksum="7B033B4B22F71423" modified="2003-03-01" version="1">MSPRRSAAEAQATRGRILGRAAEIASEEGLDGITIGRLAEELEMSKSGVHKHFGTKETLQISTLDKAFVDFWHRVVEPALAEPPGLRRLRAVCANSVGYLEEPLLPGGCLLTAALSEYDGRPGRVRDAVAEVWSRWREQLRADLTAAVDKGELPAGFDVEQALFEIVAAGLALNAAMQLQHDRTAADRARRAIERALAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJV6</accession>
    <name>Q8CJV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3800</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAD55332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36481">
        <property type="entry name" value="T36481"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733617.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975141.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3800"/>
    <dbReference type="GeneID" id="1099236"/>
    <dbReference type="KEGG" id="sco:SCO3800"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3867"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_1_11"/>
    <dbReference type="InParanoid" id="Q8CJV6"/>
    <dbReference type="OMA" id="IEFARMM"/>
    <dbReference type="PhylomeDB" id="Q8CJV6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01153">
        <property type="entry name" value="ACAD_fadE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034188">
        <property type="entry name" value="FadE5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="471"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD55332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="608" mass="66476" checksum="F98DB97836793824" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJW1</accession>
    <name>Q8CJW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3590</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2021" name="Acta Crystallogr D Struct Biol" volume="77" first="1027" last="1039">
            <title>Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states.</title>
            <authorList>
                <person name="Maciunas L.J."/>
                <person name="Porter N."/>
                <person name="Lee P.J."/>
                <person name="Gupta K."/>
                <person name="Loll P.J."/>
            </authorList>
            <dbReference type="PubMed" id="34342276"/>
            <dbReference type="DOI" id="10.1107/s2059798321006288"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAD55326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35358">
        <property type="entry name" value="T35358"/>
    </dbReference>
    <dbReference type="PIR" id="T36699">
        <property type="entry name" value="T36699"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733611.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029105.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDB" id="7LZ9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=1-231"/>
    </dbReference>
    <dbReference type="PDB" id="7LZA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.03 A"/>
        <property type="chains" value="A=1-231"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CJW1"/>
    <dbReference type="STRING" id="100226.SCO3590"/>
    <dbReference type="GeneID" id="1099026"/>
    <dbReference type="KEGG" id="sco:SCO3590"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3646"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="InParanoid" id="Q8CJW1"/>
    <dbReference type="OMA" id="KRLGEPW"/>
    <dbReference type="PhylomeDB" id="Q8CJW1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7LZ9"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7LZA"/>
        </source>
    </evidence>
    <sequence length="231" mass="24890" checksum="CEB4311D130417B0" modified="2003-03-01" version="1">MRVLIVEDEPYLAEAIRDGLRLEAIAADIAGDGDTALELLSVNAYDIAVLDRDIPGPSGDEIAERIVASGSGMPILMLTAADRLDDKASGFGLGADDYLTKPFELQELALRLRALDRRRAHSRPPVREIAGLRLDPFRREVYRGGRYVALTRKQFAVLEVLVAAEGGVVSAEELLERAWDENADPFTNAVRITVSALRKRLGEPGIIATVPGVGYRIDTAPVSEQAGGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J65</accession>
    <name>Q93J65_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0979</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625275.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027488.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0979"/>
    <dbReference type="GeneID" id="1096402"/>
    <dbReference type="KEGG" id="sco:SCO0979"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.977"/>
    <dbReference type="HOGENOM" id="CLU_2620408_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8515" checksum="1E312DF78BBEDBF5" modified="2001-12-01" version="1">MGQLRSALHSLALEGADPAQVLTRLDAYLQSLDITLRLLAQRIKQLTGQIDPLEVWPNGRLQPSSSETLSCSMGVANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JC1</accession>
    <name>Q93JC1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative phenylacetic acid degradation NADH oxidoreductase PaaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7475</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631522.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971667.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7475"/>
    <dbReference type="GeneID" id="1102913"/>
    <dbReference type="KEGG" id="sco:SCO7475"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7586"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_14_1_11"/>
    <dbReference type="InParanoid" id="Q93JC1"/>
    <dbReference type="OMA" id="FLCGPFE"/>
    <dbReference type="PhylomeDB" id="Q93JC1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011884">
        <property type="entry name" value="PA_CoA_Oase5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02160">
        <property type="entry name" value="PA_CoA_Oxy5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC44653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="368" mass="39641" checksum="89B01AFDE089CE54" modified="2001-12-01" version="1">MAPTAPVPAAPVRTRRRPAFHRLRVAAVERLCADAAAVSFEIPDELAGEFVFAPGQSLTLRREVDGRDERRSYSICAPAGSAPRIGVRVVPGGLFSAWLVDEVRPGDTVEVMAPTGLFTPDLSTPGHHVLVAAGSGITPMVSIAESVLAADDRSTVTLFYGNRRTDTVMFADELADLKDLHPTRFHLAHVLSREPREAEVLSGRLDAGRLAALVGSLVDVERADHWWLCGPQGMVADAQQVLTGLGVPAGRVHRELFYADDEPVREVRHEESGPEGPVSEVTITLDGRSTTSSLSRERSVLDGAQQTRPDLPFACKGGVCGTCRALVTDGSVDMRRNYALETAEVDAGYVLTCQSYPVSEKLTVDYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JG9</accession>
    <name>Q93JG9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC44559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631741.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971436.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7703"/>
    <dbReference type="GeneID" id="1103141"/>
    <dbReference type="KEGG" id="sco:SCO7703"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7823"/>
    <dbReference type="eggNOG" id="COG2807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038046_1_0_11"/>
    <dbReference type="InParanoid" id="Q93JG9"/>
    <dbReference type="OMA" id="VTWLPTI"/>
    <dbReference type="PhylomeDB" id="Q93JG9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="416" mass="42867" checksum="F2A5C1CC7BA87E7D" modified="2001-12-01" version="1">MSPQPASASRRYSASETPAADRARSARPVVSVGLVVAICLVAANLRTTLTGVGALLPEIERGSGLSSSWGGLLSTLPLLTFAATSPLVARASHRWGSARLLVASLGVLAVGTVVRSLPSVVFLFTGTVILSAAIAFGNVLLPALIRRSVPAHRIQGVSALYVTVMGLMAAVSSGVSAPLAHTVPGSWRTALAWGVAFTVAAFLAWLPRMRGDKPQASTGGTHSPVPWRSRLAWQVTFFMGLQSLAFYTAVAWLPSILIDRGTSSTTAGWMLFYYQVVSLASSSLLPLLTRGRHDQRWTAAGASVLVAGGFTVLVAAPALTVLACTLLGLGGGACLVLALTFQSQRAGSSGEAAALAGMAQSIGYLVAAAGPLLLGILHDTTHSWTLPLSVLAVLGIATAVAGHGAGQDRHLRQDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JI1</accession>
    <name>Q93JI1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1981</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626243.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028076.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1981"/>
    <dbReference type="GeneID" id="1097415"/>
    <dbReference type="KEGG" id="sco:SCO1981"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2007"/>
    <dbReference type="eggNOG" id="ENOG5034141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115872_1_0_11"/>
    <dbReference type="OMA" id="DYALEWP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="15550" checksum="E24C36F961C8BA77" modified="2001-12-01" version="1">MRAASGVRPLGLDTMVRLQRGRHTAGTPRRLPVPDGMTAPLGCDAVAVPALLGQQVLPRLPRVGCVYADETHWWWIVPSDSDYALEWPAPARYATGAIVPGSTSLPALLHRSDGTVPYTPPIPLYLALCRLTNTTPTWSRTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JL4</accession>
    <name>Q93JL4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629132.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973997.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4980"/>
    <dbReference type="GeneID" id="1100421"/>
    <dbReference type="KEGG" id="sco:SCO4980"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5061"/>
    <dbReference type="eggNOG" id="ENOG503483V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852359_0_0_11"/>
    <dbReference type="OMA" id="WAGTEHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC40593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34026" checksum="7FE1445949EC2051" modified="2001-12-01" version="1">MSGDGLEGLLAAVHRLTAQRMGPPVCGTAGHGTGHVCLVPPAGAGLPGIEEAIGSRFGEPLRLVTGTTTEAAGGSAGLPLRTPFGERIVEMRAWAYGDRWIGCGTVRADDADGAVRPVVLVAERADPAAGASAPATWVDGIVAVTGWETARARAVDWPAVEARLGTPLPGDYKRLVEIFGGAGAFDGYLQLQVPDAHDRSTDLVRHTEWLGEWARTHGSRLWEPYPVYPAPGGLLQWASTEQADGFYWLTGDPDPDRWPVLAKEDVPDSWERFDGPTGEFVHRMLTEPDHPFSTARWFDVHWYQDYGPAAADEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACS4</accession>
    <name>Q9ACS4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein, MmyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mmyB</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639838.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039530.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095311"/>
    <dbReference type="KEGG" id="sco:SCP1.230"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8175"/>
    <dbReference type="HOGENOM" id="CLU_057862_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ACS4"/>
    <dbReference type="OMA" id="VHEWELA"/>
    <dbReference type="PhylomeDB" id="Q9ACS4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="34881" checksum="28CC83B2D43922CB" modified="2001-06-01" version="1">MASVDGVAKDSTVCSPKRQREALRHFLRSRRARLSPDDVGLLATGRRHTPGLRREEVAVIAGVSASWYTWLEQGRDIKVSDGVLNAISQALRLDDTERAHLYRLAGVNPPQSVPATAGQTETSRLQLIVDGWLPAPAFVVDRYWNTLAANQAARSALGVGAGDQNYLAAFFTEPTARARYLDWDKLATRLVGQFRVQAARFPEDPRFDRIARQLCATDHAFADLWARHETCDTAMTSVRVRPPGEESMRFEHLILALLENADLRLMLYMPRGAHISAEAGLRLVPADPLTRNSLLQLPGRPMTSRPVERHIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD10</accession>
    <name>Q9AD10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639713.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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            <end position="402"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="573" mass="61233" checksum="D826FC552C154B0B" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC36626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="153" mass="15779" checksum="42FAD4657F7F9D78" modified="2001-06-01" version="1">MSTPTTTSLTDKNLDAALATVQTEIGRTDGKASLLLAFTGATLAGLATLAGQPLPMPARVLGGMAVAALGAATVLLLSVVRPRLGGQDRASFPYWARLAETQIHACMHGDTRAARIRIMSGIALAKFSRLRRAVDCILTALALLALAAISAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADM5</accession>
    <name>Q9ADM5_STRCO</name>
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            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">SCO4033</name>
    </gene>
    <organism evidence="4">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
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                <person name="Taylor K."/>
                <person name="Warren T."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="96" mass="10172" checksum="B4BB157BF5ABB81A" modified="2001-06-01" version="1">MRRWYGVEWVKRARRPRTWAALADSLVSRPMANTQGPQGTNDPAGSTQMFRAFVDDAPQSRQAAAPAASSGPRVGLIVGIVAAVIVVAAVAWLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN4</accession>
    <name>Q9ADN4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="11" type="ordered locus">SCO4023</name>
    </gene>
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        <lineage>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4023"/>
    <dbReference type="GeneID" id="1099459"/>
    <dbReference type="KEGG" id="sco:SCO4023"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4086"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007261_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ADN4"/>
    <dbReference type="OMA" id="GIFHQYY"/>
    <dbReference type="PhylomeDB" id="Q9ADN4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="10">
        <location>
            <begin position="113"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="733" mass="74198" checksum="2E58AE63D0848E83" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJX8</accession>
    <name>Q9AJX8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7752</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631788.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031882.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7752"/>
    <dbReference type="GeneID" id="1103190"/>
    <dbReference type="KEGG" id="sco:SCO7752"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7874"/>
    <dbReference type="eggNOG" id="ENOG5032CKR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087620_2_0_11"/>
    <dbReference type="OMA" id="RRWNEIM"/>
    <dbReference type="PhylomeDB" id="Q9AJX8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="20516" checksum="49708DF621F27644" modified="2001-06-01" version="1">MTTKSIRRPEASTHERCACEGHAGDATDETPETPRERVNRRWNEIMQETRVAQTGVQILFGFLLSVAFTPLFHDLGTFDHAVYVTTVISGATATACLIAPVSIHRFLSGQRMKDEMVEVAHRLMMCGMLLMAVTIGCTLLLILHVVVPGHMAKLLVGGVMVWFALSWYALPLWLRHRSARRATS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK76</accession>
    <name>UPP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">SCO4041</name>
        <name type="ORF">2SCD60.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAC32312" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32312.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628223.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974921.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029400.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9AK76"/>
    <dbReference type="SMR" id="Q9AK76"/>
    <dbReference type="STRING" id="100226.SCO4041"/>
    <dbReference type="PRIDE" id="Q9AK76"/>
    <dbReference type="GeneID" id="1099477"/>
    <dbReference type="KEGG" id="sco:SCO4041"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4104"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_3_11"/>
    <dbReference type="InParanoid" id="Q9AK76"/>
    <dbReference type="PhylomeDB" id="Q9AK76"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120892" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="211" mass="22922" checksum="A49FD44B3AA2E3EC" modified="2005-03-15" version="2">MRLHVVDHPLVAHKLTTLRDQRTDSATFRRLADELVTLLAYEATRDVRTEQVDIHTPVSRTTGVKLSHPRPLVVPILRAGLGMLDGMVRLLPTAEVGFLGMVRNEETLQASTYATRMPDDLSGRQVYVLDPMLATGGTLVASIRELIKRGADDVTAVVLLAAPEGVELMERELAGTPVTVVTASVDERLNEQGYIVPGLGDAGDRMYGAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWP3</accession>
    <name>Q9EWP3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sacchrp_dh_NADP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7684</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031829.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7684"/>
    <dbReference type="GeneID" id="1103122"/>
    <dbReference type="KEGG" id="sco:SCO7684"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7805"/>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044850_1_0_11"/>
    <dbReference type="OMA" id="WYNVHPG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="383" mass="39185" checksum="EBC4371119C67262" modified="2001-03-01" version="1">MTKPVIGVLGASGAVGRAAVRELRALGHTGLRLGGRTVSTLRAVAEEGPAGHDETVWADADAPDGLRAFTEGCDIVLNCVGPTYRLRATVASAALAAAAHCVDVAGDDPAAEDLRAAGDPARDGRTVVLSAGALPGLSSLLPRWLAGQGLDGTSALTAHCGGLETCSPTVAHDLMLSLTSGGADGAAYGEALAAVRGGRRVPRALRTAEDTEHRSFPGRVALQPYLSQESERLATVLGLDRLDWYNVHPGPAVRALLNQLPGRLAAGDDPAELAGRLILAADLDLAGRKPWYVMDFELSGTVSGRPATAGLTLRAASSYRLTAAVGALAVDAVLRAGVPAGVHFACDVLDPEAVVRHLREGNVADLRPTGAAAGADRVEEGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWT6</accession>
    <name>Q9EWT6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625039.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027323.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0735"/>
    <dbReference type="GeneID" id="1096158"/>
    <dbReference type="KEGG" id="sco:SCO0735"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.725"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057076_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWT6"/>
    <dbReference type="OMA" id="HDMDLGF"/>
    <dbReference type="PhylomeDB" id="Q9EWT6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="400" mass="43368" checksum="ABC84CEC621E5282" modified="2001-03-01" version="1">MTFSIGIVGAGQFSGQFARLFRAHPGVRDVYVTDLLPERAERLAATEGLAGTFPGYEAMLESRAVDAVAIFTQRWTHGPLVLQGLAAGKHVYSAVPMAISAREIADIIDAVRATGLTYMMGETSHYHPATVHARNKIAEGAFGRLFYAEGDYVHDMDLGFYDAYRYSGGTDWKATASYPPLLYPTHSVGGVLGAWRTHAVGVSAIGVVDERGDGVFDRSVSRFDNDVSNATALFEVAGGGSFRTNEFRRVGYPSHIRESRFRFFGTEASMEQLATVALWQDKTGVADISELLEPKPTTSPDDPSLQHIAPELRAAFTSGSAPVHDRARLPRAYDRMHNGHEGSHHFLADDFVTAVNSRTLPSVNAWVAARYTLPGIVAHDSARQGGARLEIPDFGDAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWX4</accession>
    <name>Q9EWX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO1752</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626024.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977073.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1752"/>
    <dbReference type="GeneID" id="1097183"/>
    <dbReference type="KEGG" id="sco:SCO1752"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1770"/>
    <dbReference type="eggNOG" id="COG5542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036370_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWX4"/>
    <dbReference type="OMA" id="VHSNLAF"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="13">
        <location>
            <begin position="93"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="396" mass="41094" checksum="2039D75947F7FCAE" modified="2001-03-01" version="1">MTDLETRGAARRGAPGPSGALRRAAPALLGYAAVRALGLLALALWSAARDKSAYTLLTARWDSLWYTRVAELGYGYEVRLPSGDVHSNLAFFPLLPWLERLGAAVTPLSYADTGFVVSLLASLAAAWGIFAVAEHVHDRRVGVCAVLLWAVLPVGVVQSMAYSESLFTALAAWSLYAVLTGRWVTAGALAALAGLTRPVGLAVTAAVWAAAVIAFARSRSEGGAGDAGGTPGARRVLGMLLAPLGAAGYVLWVGHRTGKGPLGYLDVQAGWRNGFDGGAAFARFVAAQFTSFPGALAGVGLIVGVALLVWLYVVCVRQRQPLPLLVYAGLVTVLALCASSYFGSKPRLLLPAFPLLFPPAVGLARLRTARSAPVVCGVAVAAAVYGAFWLNGSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWZ3</accession>
    <name>Q9EWZ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, molybdopterin binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625426.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027599.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1133"/>
    <dbReference type="GeneID" id="1096556"/>
    <dbReference type="KEGG" id="sco:SCO1133"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1130"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EWZ3"/>
    <dbReference type="OMA" id="PVGDTPH"/>
    <dbReference type="PhylomeDB" id="Q9EWZ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="34371" checksum="CB65E3483806AECA" modified="2001-03-01" version="1">MREFGYQRADDVSGAVALLAADPDARFLGGGTNLVDLMKTGVERPARLVDVRELPLDAIEETADGGLRIGATVTNSDLAAHPEVRRRYPALTQAVLAGASGQLRNMATVGGNLLQRTRCGYFTDLSKPCNKRAPGSGCSAVTGEHHNHAVLGASDHCVAVHPSDMGVALAAFDAVVGYETLDGPGELPLADFYLPVGDTPHRETALPAGALITGVTLPPAPVAARSRYRKVRERASYAFAIGSAAAALDVEDGVVREARLAFGAVASRPWRARAAEAVLTGAPADGDTFAAAADAELAAARPLPDNGYKVTLMRNLAVAVLTELAEETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2J7</accession>
    <name>Q9F2J7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3784</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627974.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029232.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3784"/>
    <dbReference type="GeneID" id="1099220"/>
    <dbReference type="KEGG" id="sco:SCO3784"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3844"/>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025783_0_0_11"/>
    <dbReference type="OMA" id="WHWIREE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176655" evidence="1">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="37809" checksum="7524D69FE69435A0" modified="2001-03-01" version="1">MPGTVLLLAASPVGRGCLVDAASVLPVLAAVPPAVLSGTDTANVVELADPLEPQAVLTRLRAAAAAPGPLTVYVAGQLQLDRRQRLPHLALARTTPSTVRYTALPWHWIREELRLRPSGATTLLLDLHADHETWQWLRTSPLDSGRNNAVYGRVAPPPARRAVAVPSYMRGVATILRSGHRPPPDELHQQALARAAADAPGSGAVTGADLVLTAPGPVAGDPHAVIAAAVRSGRHGDADAFAARHERAAAHAHGPASEDALHWAEVRADLAMFAGDPVRSCRSWLTVAEARLGAGQLPQAPAVEAAVDRAHHQWGRIRDAGPARELGAALAALRGRVPGRREGALDHVQRELSRLQTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2T0</accession>
    <name>Q9F2T0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628625.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029668.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4459"/>
    <dbReference type="GeneID" id="1099899"/>
    <dbReference type="KEGG" id="sco:SCO4459"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4529"/>
    <dbReference type="eggNOG" id="ENOG50324KR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135674_0_0_11"/>
    <dbReference type="OMA" id="GGCTHTD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046151">
        <property type="entry name" value="DUF6153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19650">
        <property type="entry name" value="DUF6153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176667" evidence="1">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="134" mass="12851" checksum="2B290972B3346D14" modified="2001-03-01" version="1">MTRSTGSSSRPAGRLFALLVLAVLAGVLGMHGLAPGAMPPGQAGAGHGTVMTAADGVPHADGGCTHTDGGSSHHLDHADGTCAAAGTGSAYTPPALTGALLDAPAAPAPAGAFPGAPHDGRAPPDLAELQLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Y6</accession>
    <name>Q9F2Y6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628531.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974620.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4361"/>
    <dbReference type="GeneID" id="1099801"/>
    <dbReference type="KEGG" id="sco:SCO4361"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4429"/>
    <dbReference type="eggNOG" id="ENOG5032RPR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127141_0_0_11"/>
    <dbReference type="OMA" id="DWIIDIA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="19332" checksum="E2FE76A5D21296FD" modified="2001-03-01" version="1">MTTTEWITDIALVLVVFRQLREGRLDRKTFLIPLGIVAFVAYSYLDSVPTGGNDLVLIAALAGAGAVLGIAGGVYTRIRPLDGHLMIKAGAVSAILWVLGMGARMGFQVWVEHGGGADDVARFSVAHHITGDQAWVTAFVLMAVTEVVTRVATIYVRSRVRAGAPASAASAASSGSAAPVLDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F337</accession>
    <name>Q9F337_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5133</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030075.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5133"/>
    <dbReference type="GeneID" id="1100574"/>
    <dbReference type="KEGG" id="sco:SCO5133"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5216"/>
    <dbReference type="eggNOG" id="COG2912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063810_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F337"/>
    <dbReference type="OMA" id="NNIRAWA"/>
    <dbReference type="PhylomeDB" id="Q9F337"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="3">
        <location>
            <begin position="56"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC05763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="31743" checksum="BBD9FFE2CF8F7DC4" modified="2001-03-01" version="1">MRPPRPPRPPSPQRSAELRRRFAQEARSERPDLATLCLLVGAEADGTLDEAGLDAAQVELDRLAGELPFRPGTPRAWAVALRDLLGERYGFHGVAADYQRLESSLLHEVVRRRRGLPILLSVVWLEVARRAGAPVYGVALPGHFVVGFGGESAAASGPGSAPLGERVLVDPYDGGRLLSGTDAEALVAGATGAELRASMLEPAAPLDVVARVLNNIRAWAAARPEQSAVGLWAVELALLLPAHAARLRYERAVLLVQRGEFAAGAGELEAYAEVVEAVDEAVAEEVRGEARTARAMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3G1</accession>
    <name>Q9F3G1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4539</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029717.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4539"/>
    <dbReference type="GeneID" id="1099979"/>
    <dbReference type="KEGG" id="sco:SCO4539"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4612"/>
    <dbReference type="eggNOG" id="ENOG5032TWE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111590_0_0_11"/>
    <dbReference type="OMA" id="CAVMIEE"/>
    <dbReference type="PhylomeDB" id="Q9F3G1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21796" checksum="EA2F3DB66DD1ED6E" modified="2001-03-01" version="1">MPSFSLAVPDSWWEFDIRPEGREATVRTMVDERVRETPELAPYRADLTAMLRKMAKDAHDSGALYLGCMAENFDGVPLAATVTVSVLGAENKQGVALSTDPRAIADSLRTITARREGDAWRKVTTVDIPEVGPAARTYGVEDVPVAPGDSRTLRMALTQTYIPVPGTTEQVVLVSGASPVLDLAEAFHDIFDAVTGTFRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3H6</accession>
    <name>Q9F3H6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2805</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627035.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028595.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2805"/>
    <dbReference type="GeneID" id="1098239"/>
    <dbReference type="KEGG" id="sco:SCO2805"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2863"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_1_1_11"/>
    <dbReference type="OMA" id="HDSGRFD"/>
    <dbReference type="PhylomeDB" id="Q9F3H6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="51774" checksum="D51FF64EF651C623" modified="2001-03-01" version="1">MASSTVTSAQPERPPRPNLAFRRLRGKRSPAEFAAAVRRAAREIGERVSCDARYVGRVEAGEIRCPNYAYERVFLHMFPGRTLTDLGFAPRSSVRGRQARTPGESRGAGEPYETHDTQDVLDTQDVRDAQDLYETHDNNEESDVLRRAFMTSGATVAAASLGPLGLAVDAAAAGRPARRAGTGEAGALEEAVRRIRLLDDRHGADGLYRRAAAPLRTAYALLDAGVSRQATADRIYTGAGELAISVGWLAHDSGRFDDARSHYAEALATARMNGDAGLEAHAFCNMAFLARDAGRPREAVRAAQAAQRAARPLGSARLMSLLALREAGGWAGLADRVGCEQALVRAQTFFERGPSDTDPEWMSFYGEAELEGLEAQCWSTLGDWPRAARHARRAADLQDPHFTRNLALYSAELADDLARGGRPDEAAGAGMRVLDLLGEVQSSRIHTMLAGTARVLLPHRRASGVSTFLDRHAALPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBS7</accession>
    <name>Q9FBS7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar-binding integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7165</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631224.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971977.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7165"/>
    <dbReference type="TCDB" id="3.A.1.1.42">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="TCDB" id="3.A.1.1.43">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1102603"/>
    <dbReference type="KEGG" id="sco:SCO7165"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7266"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="PhylomeDB" id="Q9FBS7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC01654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="32949" checksum="2038CC6EF0555E16" modified="2001-03-01" version="1">MAPATAPNRRPRRPAPAPRTRRRASGTVAGTSLWRLPLLLVSASFMVIPLWLLVVNAFKSEQDIRDSPFGLPLTRLSLRPLRDAFANPDFDVVRAYGITLLFVLLVNVLSLLVSAPVSYVIARGTTRWHTALLLLFVAGTFVPSQVLLIPVVYVLKYLGLMGTVPGFVLFETALTLPVSVFLYSAYIRTIPRELDQAASVDGLGRLRTFQLVVLPLMRPMVATAVILHSLSVWNDFANPQIILGPGSGLYTVTTGVYAAVGKYSTHYAVVFPNLLLAVAPALAFFAIMQRHIISGLTSGALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC16</accession>
    <name>Q9FC16_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7068</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631130.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7068"/>
    <dbReference type="GeneID" id="1102506"/>
    <dbReference type="KEGG" id="sco:SCO7068"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7173"/>
    <dbReference type="eggNOG" id="ENOG5032H62">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123912_0_0_11"/>
    <dbReference type="OMA" id="RSKPYRL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325313" evidence="3">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="19381" checksum="BD560687C08E6039" modified="2001-03-01" version="1">MYRRPCRRRAVHMRISSPLLRSGATLAAATVLPVALAAAPAPAGPGISVSTTGTTVSVTTTACAQLNGSWGTASLLTSSQRDFAQGRQVALSGSASGQSAAWSGISPGTYTVIVMCSNNSTAGTQTVIVSSAPSPSPSRAATPTPSASPGGVMGGLGGAVQDYGTATLVAGGALVGAGVIAGAWFLRRRSKPYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J9</accession>
    <name>Q9K3J9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4821</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628977.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029889.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4821"/>
    <dbReference type="GeneID" id="1100262"/>
    <dbReference type="KEGG" id="sco:SCO4821"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4898"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097561_0_0_11"/>
    <dbReference type="OMA" id="EVWAPRH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB97424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="26383" checksum="3054BF2D1BE4B81B" modified="2000-10-01" version="1">MVPPPTTEDEGTGTQYRLAPGERLVFGRSVPGGGLRIGHDGVSRRAGEIAAHGTFWTLSNLSAHQTYVVENPEGAGEHIKVAPGRLDAPVPFEFSRIVLPAAGDLLPVEVWAPRHDYLRGEDGTDGEPTAPAFSVDRTKRYFAVLAALCEPRLRGAPHAPLPTMDQVVERLRPAWPAASRTSVQWNIDYLAVKLRLKPGPETAEPGPRLNGKKESLVSLALRFDLVREDDLVVLAAPSGQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3K1</accession>
    <name>Q9K3K1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4819</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628975.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974152.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4819"/>
    <dbReference type="GeneID" id="1100260"/>
    <dbReference type="KEGG" id="sco:SCO4819"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4896"/>
    <dbReference type="eggNOG" id="ENOG502ZPXH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1676924_0_0_11"/>
    <dbReference type="OMA" id="RWTSTAY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176720" evidence="1">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB97422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="16504" checksum="4A7CBC6DF6507919" modified="2000-10-01" version="1">MNILKPAALLLAATALAAGSTAAATAADSPGGTRVTGLQQTAGQVLADSPKPLRVTADAVEYEGLTVTDAPVTKGAQDLPCDYGHLCMVVKGTKFDFYKCQTWNLTNWTGDGPFTNNQTRGTVAKFFNKDGSVRWTSTAYQAGTASWDPIWSLRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3N6</accession>
    <name>Q9K3N6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1024</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625319.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1024"/>
    <dbReference type="GeneID" id="1096447"/>
    <dbReference type="KEGG" id="sco:SCO1024"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1019"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008749_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3N6"/>
    <dbReference type="OMA" id="TDMIEVG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASH" evidence="3">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="3">
        <location>
            <begin position="334"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="610"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB96009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="833" mass="87887" checksum="26E0B2E87DC29142" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3P1</accession>
    <name>Q9K3P1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1107</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625401.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027578.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1107"/>
    <dbReference type="GeneID" id="1096530"/>
    <dbReference type="KEGG" id="sco:SCO1107"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1104"/>
    <dbReference type="eggNOG" id="ENOG5031IDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524290_0_0_11"/>
    <dbReference type="OMA" id="ADWIEGP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046186">
        <property type="entry name" value="DUF6214"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19720">
        <property type="entry name" value="DUF6214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="16758" checksum="BC52C4FAA43A1AEA" modified="2000-10-01" version="1">MSVRHAWVVSEGSTTTSWFDVRLAFADGARVDALAVLSGAHVRVEDVRARPPLSLDDLAVLAEWLEDPLFEACVAAPARGTPAEPRRARAPWPRGREGRRLVAQEYRTAREEGGDPVLAVMRATGHSRRRSLRLIGQARDEGFLAPRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K422</accession>
    <name>Q9K422_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1077</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625371.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027561.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1077"/>
    <dbReference type="GeneID" id="1096500"/>
    <dbReference type="KEGG" id="sco:SCO1077"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1074"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_11"/>
    <dbReference type="InParanoid" id="Q9K422"/>
    <dbReference type="OMA" id="VNVPGWR"/>
    <dbReference type="PhylomeDB" id="Q9K422"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="31379" checksum="0D6BAC44D1D6886D" modified="2000-10-01" version="1">MHTDLVAALDIGGTKIAGALVDGHGRIQARAQRATPAREDGDTVMRAVEDVLAELTVSPLWGRASAVGIGSAGPVDASAGTVSPVNVPGWRDYPLVRRVQAAAGGLPVELIGDGVAITAAEHWQGAARGHDNALCMVVSTGVGGGLVLGGRLHPGPTGNAGHIGHISVDLDGDPCPCGARGCVERIASGPNIARRALEAGWLPGPDGDTSAAAVAASARLGDPVAVASFERAAQALAAGIAATATLVEIDIAVVGGGVGKAGDVLFAPLRKALTDYATLSFVQRLAVVPAQMGTDAGLVGAAAAALTRTADVTAAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K438</accession>
    <name>Q9K438_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative bifunctional protein (Secreted sugar binding protein/sugar hydrolase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1061</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625355.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027552.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1061"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="GH93">
        <property type="family name" value="Glycoside Hydrolase Family 93"/>
    </dbReference>
    <dbReference type="GeneID" id="1096484"/>
    <dbReference type="KEGG" id="sco:SCO1061"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1058"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036301_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K438"/>
    <dbReference type="OMA" id="KMVHQTT"/>
    <dbReference type="PhylomeDB" id="Q9K438"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176732" evidence="1">
        <location>
            <begin position="35"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="437"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="555" mass="58835" checksum="E78C9A88990B2786" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C1</accession>
    <name>Q9K4C1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alkanal monooxygenase (Luciferase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629529.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030217.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5390"/>
    <dbReference type="GeneID" id="1100830"/>
    <dbReference type="KEGG" id="sco:SCO5390"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5471"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_3_0_11"/>
    <dbReference type="InParanoid" id="Q9K4C1"/>
    <dbReference type="OMA" id="WVDLEVF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="342" mass="36443" checksum="7D5AF4695ABF1E7E" modified="2000-10-01" version="1">MRVGSFVLGAQFPGQGQGEALHRAVRSAEVAEEAGLDTVWLAEHHFVPYGTCPSAVTLAALLLGRTRRVRVGTAVSVLPTVHPVALGEQAALLHVTSGGRFSLGVGRGGPWVDLEVFGAGLEAYEKGFPDSLDLLLRWLREPAVGASGDRYRFREVPVVPRPSESLSEEPGPEVVVACTSPSSVRMAAERGLPMLLGMHVGDEEKAEMVALWRRHARAAGRPAAEIHGAGHVSAGVCQIADRRTDAAETLLKAMPGWLRQGLGAHVTVDGRARQMRDPHAYTELLCGLHPVGTPRLCADRLAATGERTGISRFALLVEGSGDLAATEENVRRLGAEVLPQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4K8</accession>
    <name>Q9K4K8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ordered locus">SCO7306</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.7408"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_106245_6_2_11"/>
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    <dbReference type="PhylomeDB" id="Q9K4K8"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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    </dbReference>
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    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
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    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB93744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="83" mass="9330" checksum="11CDEFF70EB5860E" modified="2000-10-01" version="1">MDNWREHAACRTEDPDLFFPIGTTGPAALQTEQAKAVCRTCPVQEQCLRWALDTGQTLGVWGGTSELERRALKRREAARRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXM0</accession>
    <name>Q9KXM0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4337</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4337"/>
    <dbReference type="GeneID" id="1099777"/>
    <dbReference type="KEGG" id="sco:SCO4337"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4408"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_11"/>
    <dbReference type="InParanoid" id="Q9KXM0"/>
    <dbReference type="OMA" id="VQVWHVY"/>
    <dbReference type="PhylomeDB" id="Q9KXM0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="44"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB93411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="459" mass="48132" checksum="50E2CB555C7BBE0A" modified="2000-10-01" version="1">MSTGSGAASAPAPDGPDTPTTPDGPTGPAAPRRTSMFASLKVRNYRLFFMGQVVSNIGTWMQRIAQDWLVLSLTGSSAAVGITTALQFLPMLLFGLYGGVLVDRLPKRPTLLVTQTAMALTALALAALTLSGHVQVWHVYVAAFAMGLATVMDNPARQTFVSELVGRDQLQNAVSMNSANFQSARLVGPAVAGLMITGVGTGWAFLANGLSFVAPLTCLLLMRARELHAGRPTPRGKGQLREGLRYVAGRPELIWTITLVGFIGTFGFNFPVFLSAFADDVFDAGAGAYSLFNTLMAVGSLAGALLAARRGTARLRVLIAAALGFGALEIVASTAPELWLFALLMVPIGVFSMTVNVTANTSIQMSTDPAMRGRVMALYMMVFLGGSPVGAPIVGWVTDTYGARVGFAAGGAVAATAALVIGLVLARVGNLRLSVGWHRGHPQVRFVPRERQEALAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXX9</accession>
    <name>Q9KXX9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative WD-40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3869</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628056.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029283.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3869"/>
    <dbReference type="GeneID" id="1099305"/>
    <dbReference type="KEGG" id="sco:SCO3869"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3943"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002352_0_2_11"/>
    <dbReference type="InParanoid" id="Q9KXX9"/>
    <dbReference type="OMA" id="QIFVLNH"/>
    <dbReference type="PhylomeDB" id="Q9KXX9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1468"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1514"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1560"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB92989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1676" mass="177267" checksum="7FBADE5C36F73D60" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY71</accession>
    <name>Q9KY71_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative NPL/P60 family secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4793</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628950.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029867.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4793"/>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="GeneID" id="1100234"/>
    <dbReference type="KEGG" id="sco:SCO4793"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4869"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034085_1_2_11"/>
    <dbReference type="InParanoid" id="Q9KY71"/>
    <dbReference type="OMA" id="GYAMQFQ"/>
    <dbReference type="PhylomeDB" id="Q9KY71"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176759" evidence="4">
        <location>
            <begin position="42"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="232"/>
            <end position="347"/>
        </location>
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            <begin position="202"/>
            <end position="231"/>
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    </feature>
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            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB92656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="347" mass="37095" checksum="57926262A4450B33" modified="2000-10-01" version="1">MGTHRRPRQRAKGGGRARTAATITLAGAATATGLGGTTVHADPQPTAAQVRAKVDKLYQEAEVATEKYNGAKEKADAAERRLEDLRDEAARKEDRLNSAREALGSVAAAQYRSGGLDPALQLALSSDPDRYLDGAAFAERAGSRRQAEVGRVRKELRDIEQLRGAARVEAASLRSRRAELKRHRETVIGKLEKARRLLSRLTTEERADVGDRASRSAPGPREGLTPSSQAPDSRAAAAVAYAYQKLGSPYVWGATGPNAFDCSGLTQAAYRAAGVSLPRTTYAQIDAGRRVSRSELLPGDLVFFYSGISHVGIYVGNGRMIHAPNPSAPVRVAPVDEMPFAGATRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH6</accession>
    <name>Q9KYH6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-hydroxyacid-family dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2696</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626930.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028521.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2696"/>
    <dbReference type="GeneID" id="1098130"/>
    <dbReference type="KEGG" id="sco:SCO2696"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2752"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_11"/>
    <dbReference type="InParanoid" id="Q9KYH6"/>
    <dbReference type="OMA" id="GGHPTTQ"/>
    <dbReference type="PhylomeDB" id="Q9KYH6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="114"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="34718" checksum="C0966FF0B365D934" modified="2000-10-01" version="1">MRLRCAVLDDYQGVATEAADWSPVADRVEVVSHGTHFPDEDALAAALADADIVVTLRERVPFPGSLIARLPRLKLLVASGMRNSVIDYAAADAHGVTVCGTASSSTPPVELTWALILGLARGIVQEANGLREGGPWQQTVGADLHGRRLGLLGLGKIGGRVAQVGLAFGMRVSAWSQNLTQERTDEVGVELASSKEELLRTADFVSVHLALGERTRGLLGPAELALLKPTAYLVNTSRAAIVDQEALLAALHEGRIAGAGVDVFDTEPLPAGHPMRTAPRLLATPHLGYVSRANYATYYGQAVEAVGAYLAGSPVRRLPVGSPPPAPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI8</accession>
    <name>Q9KYI8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-binding membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2684</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626918.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028512.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2684"/>
    <dbReference type="GeneID" id="1098118"/>
    <dbReference type="KEGG" id="sco:SCO2684"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2740"/>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016609_1_0_11"/>
    <dbReference type="OMA" id="TPWLRLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="337"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="826" mass="88427" checksum="D350D8BBBE9621B6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYJ4</accession>
    <name>Q9KYJ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6947</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631013.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031329.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6947"/>
    <dbReference type="GeneID" id="1102385"/>
    <dbReference type="KEGG" id="sco:SCO6947"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_4_1_11"/>
    <dbReference type="OMA" id="KSAISHW"/>
    <dbReference type="PhylomeDB" id="Q9KYJ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="501" mass="54035" checksum="501BA05F9620876A" modified="2000-10-01" version="1">MSDLAATLSESRIPFEGYALADGKAAKGAKDHYGTEGQPMARDRNVVLAALLREAGWSQPQAAAAVARVATECGVRELEAISRSHISMWVLGTKPSGRAPHILRETLSRRLGRRLSLADLGLEEEPTGTTDTGSDWSVDPLTALAELGSDDLDMHRRKLLATAAYSAAGLALPPTSWWVAAPAAAANRRPSSSRSVTQADVDDVRDLTVYYSARDQQRGGATGRQALASHLLDEAVPLLGGRFRTDQLRRDTHSAVAEMTYLAGWMAFDAGEHRTAQRYLTIAARIAAEAEDGPLGGHVLRALAHQAVDLGHPRRALALADASMSRDRYGQASHREKALLAIVHARALAADGDRSGTLAAISRAERDLARADTSEAPARVGFFQEASLAHETACALRDIGQPRDAEIHFKRSVATRRRQQFARTHSVTLGYLGAVQVQRGNLDEACATWNEALDAMTGVQSGRTRDVIVRIQSDLSPVRQRGGRHVTALDRRARGMLRAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYW3</accession>
    <name>Q9KYW3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3018</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627240.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975794.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3018"/>
    <dbReference type="GeneID" id="1098451"/>
    <dbReference type="KEGG" id="sco:SCO3018"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3078"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KYW3"/>
    <dbReference type="OMA" id="SRAWAWL"/>
    <dbReference type="PhylomeDB" id="Q9KYW3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="248"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="35158" checksum="4B8C3589209AF73E" modified="2000-10-01" version="1">MDPTTDNAGQSAAPGNARAALEALRAEIAKAVVGQDAAVTGLVVALLCRGHVLLEGVPGVAKTLLVRTLAAATELDTKRVQFTPDLMPSDVTGSLVYDARTTEFSFQPGPVFTNLLLADEINRTPPKTQSSLLEAMEERQVTVDGTPRLLPEPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLTVPLPTRQDEIDVLTRHAAGFNPRDLRAAGVRPVASAADLEAARAEAAKTTVSPEITAYVVDICRATRESPSLTLGVSPRGATALLSTARAWAWLTGRDYVTPDDVKALALPTLRHRVQLRPEAEMEGVTADSVINAILAHVPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ63</accession>
    <name>Q9KZ63_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3085</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028758.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3085"/>
    <dbReference type="GeneID" id="1098518"/>
    <dbReference type="KEGG" id="sco:SCO3085"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3146"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168320_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="13226" checksum="0C8F1151DD942D4C" modified="2000-10-01" version="1">MSRAGPRPPHGRGRPCDVRRGRLLRGWRLALLWKQIVTILAVGAFSFVLTWIIAKAVDVVVGFTDKEAYADVPGQEEERAYDFRTAERLDALAGAGRGTDRETLDEIRRLLREHREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZD9</accession>
    <name>Q9KZD9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631016.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031332.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6950"/>
    <dbReference type="GeneID" id="1102388"/>
    <dbReference type="KEGG" id="sco:SCO6950"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_0_0_11"/>
    <dbReference type="OMA" id="ARAFGKM"/>
    <dbReference type="PhylomeDB" id="Q9KZD9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="467" mass="50886" checksum="EC56DC62150DCC76" modified="2000-10-01" version="1">MPRPEKQLTPDASPRDWFGHELRTWRKKRGPLTHAELGAKVQVSGSLIEKIEKGTATCSKDLADRLDEVLQTGGVLTRAWGMVFGQTENGRPETESAPPGRAEVPVQVHEGSILDRGSTTPPSGSPASVDRRAFLATSGLAVIAPIDLVHLVTPAAPRETPTQIRPREIRQVKSLADVIHRQDNEYGGGGAVRELARGAIMWGASLLPVPCPESLRPELLSSIARLGIVVGASQFDAYAHDDARVSFRLAAECAEEAGEWHLRAKTYSFMARQEIWVGDPDSGLTHAEKGLVRSDRLTATERAMLHTARARAFGKMRDVANTLRAVGEADAAFEQSDPAQDPPWMAYYDYAQHHGDTAHALFDLAVHADQDPGQAARRFEIAVKGHANAFARSRAISETKLASLVMARGDDPRHAVVLGHRALDDVGKLTSCRAAEDLRELARYAGRHRNIPEASDLRERIAATVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZR9</accession>
    <name>Q9KZR9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative conserved ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2882</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627110.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975927.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2882"/>
    <dbReference type="DNASU" id="1098316"/>
    <dbReference type="GeneID" id="1098316"/>
    <dbReference type="KEGG" id="sco:SCO2882"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2942"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZR9"/>
    <dbReference type="OMA" id="TECDARE"/>
    <dbReference type="PhylomeDB" id="Q9KZR9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="182" mass="19408" checksum="C41C87A28B8D0EBA" modified="2000-10-01" version="1">MVAGGFGVGKTTLIGSVSEVRPLRMEEPITQASAGVDDLRGTPHKTTTTVAMDFGRIHMAGGRLALYLFGLPGQSRFQPLWEDLAEGALGCLVLADTRDLDASHDALGLLDGAGIPYAVAINTFPGSPSYPEAELREALALEPATPLTYCDARDRTSSLHALITLTEYLSEHRSAALLESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZZ4</accession>
    <name>Q9KZZ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4432</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628599.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029649.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099872"/>
    <dbReference type="KEGG" id="sco:SCO4432"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4501"/>
    <dbReference type="eggNOG" id="ENOG502ZECZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1234416_0_0_11"/>
    <dbReference type="OMA" id="REYHEEW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24996" checksum="936740A9BDFD4188" modified="2000-10-01" version="1">MISPKRSADELPGDPRRLNLEYRTWHFVGSAGDENGFDEWHVSVRSGRSAEIGSMKLFRLRMDERFSPFPFSDAQAYDTGLSNLVLGVYDLGRGGYRQEFRDAMTSCDGDLLVLFDIRLDPAWRGFGLGPVLAAEAVWTLADGCCAVLAATHPTEFPDAPMGEAAYRRAAEKIAALWKDVGLRWRARPLGHLLDPRSGEARDLRNERRGDLDALADAWRAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0F3</accession>
    <name>Q9L0F3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4689</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628848.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029816.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4689"/>
    <dbReference type="GeneID" id="1100130"/>
    <dbReference type="KEGG" id="sco:SCO4689"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4761"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141675_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L0F3"/>
    <dbReference type="OMA" id="SEHQNPG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="11591" checksum="0F1345A0EDE49EDB" modified="2000-10-01" version="1">MQKLSLDALAREHLERAAAGSHGRSATTVHGGHELVLRQTLLALTAGTTLAEHENPGEATVQVLRGRVRLTSGDTSWDGRAGDLILIPPARHSLEALEDSAVLLTVAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0M3</accession>
    <name>Q9L0M3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4637</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628798.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029785.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4637"/>
    <dbReference type="GeneID" id="1100078"/>
    <dbReference type="KEGG" id="sco:SCO4637"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4708"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094876_4_1_11"/>
    <dbReference type="InParanoid" id="Q9L0M3"/>
    <dbReference type="OMA" id="AEIVFNG"/>
    <dbReference type="PhylomeDB" id="Q9L0M3"/>
    <dbReference type="BRENDA" id="4.2.1.59">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB77411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="15245" checksum="F896832CB4B6A8CF" modified="2000-10-01" version="1">MQSKIAYSDVEVGTELPAQSFPVDRATLVRYAGASGDFNPIHWNERFAKEVGLPDVIAHGMFTMAEAIRVVTDWTGDPGAVVEYGVRFTRPVVVPNDDRGAVIEVSGKVAAKLDDNTVRVDLTATSAGQKVLGMSRAVVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0W0</accession>
    <name>Q9L0W0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3744</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627935.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029204.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3744"/>
    <dbReference type="GeneID" id="1099180"/>
    <dbReference type="KEGG" id="sco:SCO3744"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3805"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071058_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L0W0"/>
    <dbReference type="OMA" id="PLEVERW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="261" mass="27464" checksum="1AEB93EE4CBBB486" modified="2000-10-01" version="1">MKGAARLAPGRPSPAPAWETSDPYAAALRSGHGPLYLRRTDGWLLPLEVERWCARADAVDLDVLDRCEGAVLDVGCGPGRLVAELAARGRTVLGIDVSEAAVTRTVRLGGQSLRRSVFEPLPGEGRWDTVLLMDGNVGIGGDPRTLLGRVAALLAPGGLLIAETAGSDIDERAHVQVVDVTDGDAAGSPFPWARIGTPALLGHARDTGWRPAAQWTSGERRFVALRSSRSASSSAEPPNSTAVTSSQRARKPSADSPVTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L107</accession>
    <name>Q9L107_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1452</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625733.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977373.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1452"/>
    <dbReference type="GeneID" id="1096878"/>
    <dbReference type="KEGG" id="sco:SCO1452"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1462"/>
    <dbReference type="eggNOG" id="ENOG50335CN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080120_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L107"/>
    <dbReference type="OMA" id="ACWRPLF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="231" mass="25208" checksum="9F9E832EC9E29DAA" modified="2000-10-01" version="1">MAHCEQVPTAALTVDTVLSRLRALDTALPAGDGVAVFNRVYLAVTEAVDRHIDGGRFADASAATALDVRFAERYLAAVDAAEEDRRPPACWRPLFQFRRHPGVRPLQFALAGINAHIGHDLALAVVDTCRTLGCDPVDLEDEFDRVGDLLVSLEERVRDELMPGPDVLQIADPLTHLLGSWSLDRAREATWAAARALWALRRLPDVAGEFTVRLDAAVGFAGRMLLTPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L273</accession>
    <name>Q9L273_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1536</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625815.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1536"/>
    <dbReference type="GeneID" id="1096962"/>
    <dbReference type="KEGG" id="sco:SCO1536"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1545"/>
    <dbReference type="eggNOG" id="ENOG502Z86X">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005777_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L273"/>
    <dbReference type="OMA" id="MDLRFYH"/>
    <dbReference type="PhylomeDB" id="Q9L273"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="YetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="PTHR40081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="YetA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB70938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="822" mass="91740" checksum="F210BCA05DA3C3E7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L277</accession>
    <name>Q9L277_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625811.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027834.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1532"/>
    <dbReference type="GeneID" id="1096958"/>
    <dbReference type="KEGG" id="sco:SCO1532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1541"/>
    <dbReference type="eggNOG" id="ENOG502ZBTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053142_0_0_11"/>
    <dbReference type="OMA" id="YGRWTPP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB70934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="425" mass="44964" checksum="350DB2E7781CC609" modified="2000-10-01" version="1">MTHRPAGGGPPRPFEPLRSVRPHPADAPGDRPRDGAPPEPGTVDPAVLTALLHRHGWRRRGGAPARYGRWTPPGPAAGGASLLVPVSRAFPDRDDLLGEALLALSRSGTPAAREILLSLAVPSDEIRWERDMPTGPGATATWTAEEQLRAAARRMLLAGALATRARAGYYGARHRRAAETALESVLVGPAPDGRHLAAFLPVGTGRPLAVRLHQALYAAREAVDYRRATGGAEAFDSAVAAGVSHELTESLVALVRGTEGARIAVGWAPAAGVPEGCGTLTEPVEFSPGDLPALREAAARYLRAEPSVPVRITGTVDRMRRPGPRGPGTVRLRVLAGAEVPHVRVALDEEAYRIAGHAHLVGLPVRMLGRLESRGGFRRLTGACEITPVQVDDAERDRLLKAVQEHVEVAAFFEEACGDGGDCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2B7</accession>
    <name>Q9L2B7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5403</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629542.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973594.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5403"/>
    <dbReference type="GeneID" id="1100843"/>
    <dbReference type="KEGG" id="sco:SCO5403"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5485"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="InParanoid" id="Q9L2B7"/>
    <dbReference type="OMA" id="EMGSDDY"/>
    <dbReference type="PhylomeDB" id="Q9L2B7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB70633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24178" checksum="CE4CB5DE69947802" modified="2000-10-01" version="1">MRLLIVEDEKRLAVSLAKGLTAEGYAVDVVHDGLEGLHRAGEGVYDLVILDIMLPGLNGYRVCAALRAAGHDVPILMLTAKDGEYDEAEGLDTGADDYLTKPFSYVVLVARVKALLRRRGQGAGASPVHVHGDLRVDTAARRVFLGEDEATLTAKEFAVLEQLVVRAGQVVSKAEILEHVWDFAYDGDPNIVEVYVSALRRKLRAGLIRTVRGAGYRLETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCY1</accession>
    <name>Q9RCY1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0929</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625227.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027452.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RCY1"/>
    <dbReference type="STRING" id="100226.SCO0929"/>
    <dbReference type="GeneID" id="1096352"/>
    <dbReference type="KEGG" id="sco:SCO0929"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.923"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RCY1"/>
    <dbReference type="OMA" id="RAMEFMP"/>
    <dbReference type="PhylomeDB" id="Q9RCY1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="270" mass="29586" checksum="0F6CB958D5B8293F" modified="2000-05-01" version="1">MERPAWAPRSIDISVPSVSRIYDFYLGGSHNFEVDREAARRAMEFMPGLPKIMQANRAFMRRAVRFAAGEGIDQFLDIGSGIPTFGNVHEVAGRSRPGARVVYVDHDPVAVAHSEAVLAGHDDADVVAGDLLKPREILASPQVERLLDLNRPVALLLVAILHFVEDEDDPYAAVAELSDALAPGSLLVLTHASYEGIPLPAERAGGAVDVYKDIRNPLIMRSREDIARFFKGYDMVEPGLVPMPRWRPEGEPEEEDPYAFSGFAGVGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD05</accession>
    <name>Q9RD05_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0906</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625205.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027434.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0906"/>
    <dbReference type="GeneID" id="1096329"/>
    <dbReference type="KEGG" id="sco:SCO0906"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.900"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_3_1_11"/>
    <dbReference type="OMA" id="ERWHGWG"/>
    <dbReference type="PhylomeDB" id="Q9RD05"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="165" mass="18885" checksum="9FB4E5C607AC828C" modified="2000-05-01" version="1">MHETPRHRRPDSDPVPDHTTPRGVRMSKPPLPPEAVELLRRPNPCVMATLRKDGAPVSTPTWYVWDDDGRVLINLDAGRVRLGHLRRDPRVTLTVLSGDDWYTHVTLIGRVAEMSDDEDLSGIDRLSRHYTGNPYPNRERPRVSAWIEVERWHGWGELKDSSQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD18</accession>
    <name>Q9RD18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0892</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625191.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027421.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0892"/>
    <dbReference type="GeneID" id="1096315"/>
    <dbReference type="KEGG" id="sco:SCO0892"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.884"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RD18"/>
    <dbReference type="OMA" id="IPRRYQH"/>
    <dbReference type="PhylomeDB" id="Q9RD18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="35026" checksum="311C72DB2C07F116" modified="2000-05-01" version="1">MNVTPSVWLLTVAGLCVLVAADFFIGRKPHDVSLREAGIWTAVWVVLACLFGVGLLVFGGGGPGGEFFAGYLTEKSLSVDNLFVFVLIMAKFAVPSQYQQRVLMIGVLVALVLRAAFIAAGAAIISAFSWVFYVFGAFLIWTAWKLIQDARKDEHEQEYEENKLLKWIERRFGVADRYHGTRLWVEENGRRVMTPMLVVMLAIGFTDILFALDSIPAIYGLTQDPYIVFTANAFALMGLRQLYFLIGGLLKRLVHLSYGLSVILGFIGVKLVLHALHESGVHVPEIGIPFSLGFIVLVLAVTTATSLWATRRRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDE0</accession>
    <name>Q9RDE0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2551</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626789.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976253.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2551"/>
    <dbReference type="GeneID" id="1097985"/>
    <dbReference type="KEGG" id="sco:SCO2551"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2596"/>
    <dbReference type="HOGENOM" id="CLU_140384_0_0_11"/>
    <dbReference type="OMA" id="WSHRQKR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB66229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="12624" checksum="F9A98C244505E0BD" modified="2000-05-01" version="1">MDDLTTWLWSHRQKRGRDGVWRDALTLYQNGVRVRFVFRAGAPDSGRWTTEGGYWYEGCVGDDRGNLLNLREPGVVRALVEAAGRRALLPGPGGRPVELDGWELFPAVVAAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP1</accession>
    <name>Q9RDP1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2396</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626642.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976410.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2396"/>
    <dbReference type="GeneID" id="1097830"/>
    <dbReference type="KEGG" id="sco:SCO2396"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2437"/>
    <dbReference type="eggNOG" id="COG1764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106355_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RDP1"/>
    <dbReference type="OMA" id="TPEKGFK"/>
    <dbReference type="PhylomeDB" id="Q9RDP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="14236" checksum="CDB01349BC70E34A" modified="2000-05-01" version="1">MPIQQSEVLYTAVATAENGRDGRVATDDGRLDVVVNPPKEMGGNGAGTNPEQLFAAGYSACFQGALGVVARQEGADISGSTVTAKVGIGKNDDGFGIIVEISAEIPTVDAATARSLVEKAHQVCPYSKATRGNITVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDR6</accession>
    <name>Q9RDR6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626500.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028226.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2251"/>
    <dbReference type="GeneID" id="1097684"/>
    <dbReference type="KEGG" id="sco:SCO2251"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2288"/>
    <dbReference type="HOGENOM" id="CLU_1234414_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24665" checksum="65C22C3827C41AC4" modified="2000-05-01" version="1">MRECWFCGEETPRSWHDHVLGLHKDADTTMTPFVIVLRSTWQMETVSVPRCARCHTGHQLERTAAVLSLAALIAYAASGQLDRLLGILSPSTGERVVAAIWAAVACLPGLVWFAIRLGRLPWQRLAPRRRGYARHHPEYVELRADGWKPGAGPLHYWRSPPNPHHPPPANRPRRLIGGSFELLGAACGLAVPVAYFTGYEELAGVLIAATAGLLFVASKVKPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI86</accession>
    <name>Q9RI86_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0089</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36989">
        <property type="entry name" value="T36989"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624437.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0089"/>
    <dbReference type="GeneID" id="1095517"/>
    <dbReference type="KEGG" id="sco:SCO0089"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.77"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9RI86"/>
    <dbReference type="OMA" id="VYDEATW"/>
    <dbReference type="PhylomeDB" id="Q9RI86"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="345" mass="37143" checksum="673B9D614AE106A7" modified="2000-05-01" version="1">MYPVLDHRFAPHVSSLAVDLLRHLRIFVAVAEELHFSRAADQLGMAQPPLSQAVRRLETELGAELFDRSRRQVKLTPAGAVLLDEARSLLTGEKRLRTLARRAGDGELGTLRAGIPPGTMVATLSLLLGACAEHYPGMSVDLQEITTGEQLRLIASGGLDVGLVHQPVDITELRIGPEASVELGVVLPRISPLAQLPEVPLAHLAGQDLVLLPREQAPGWYDRILDTCRAGGFVPTGLRHASRPELLLALVSAGHGIAFGQGAVAGKEPRVVWRPLSGRPLIQRTSAVWSAVRSSHPAAPHFAELAADVLARDRTATLHGDDGAPAETGSPRPWAVVYDEATWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIU1</accession>
    <name>Q9RIU1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0966</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625263.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027477.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0966"/>
    <dbReference type="GeneID" id="1096389"/>
    <dbReference type="KEGG" id="sco:SCO0966"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.963"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_11"/>
    <dbReference type="InParanoid" id="Q9RIU1"/>
    <dbReference type="OMA" id="LGWQPKG"/>
    <dbReference type="PhylomeDB" id="Q9RIU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="32946" checksum="DCC53AB330AA0067" modified="2000-05-01" version="1">MHVFVAGGTGHSGSHIISELVAAGHEVTGLARSDAAAATLSALGAKVHRGDLQDLDGLKEAAADSDGVIHVAHRQDLLPSGGIDAVAAAELPIVRAYGEALAGTGKPLVAAGSIGSPGTGRDLGRPSTEEDPALPVGDEHKGTLRARNVVEATVIGLAERGVRSSVVRIANIAHSTADRAGFLPTLIALAKERGFAGYPGDGSNLWNAVHIRDAASLFRLALEKGPAGSYWHAVEDGGIPVREIAEAIGNRLGLPAVSVPLDELMLPGHFGFLTNIVTRSYPTSNLITRKTLGWEPARPGLLADLDNGHYFPSTDVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJN6</accession>
    <name>Q9RJN6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624920.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027242.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0608"/>
    <dbReference type="GeneID" id="1096031"/>
    <dbReference type="KEGG" id="sco:SCO0608"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.590"/>
    <dbReference type="eggNOG" id="ENOG5031BG4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075313_0_0_11"/>
    <dbReference type="OMA" id="QYSAQVA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="30232" checksum="EB9B834271BDDDAC" modified="2000-05-01" version="1">MSESTMQSATELASQYSVQVTDDLERNVKEQERVSTEITALQQQLAALQHDHALLVNMQQALGITPQPARSAPEPASSTGAATVPAPRGSAAAQSETDRRTRGRKTTTAPKRAAAAKPGAKPASKPKAKKATKSTATATTKATTKATAKTDKPADPKADPKPSTKTGTKTAPDAVTTAPATSAAKPAGKPAAKKAAARATAQPTLVELVREHLVGQREPRSAAEVTTALSEAHSGRTVKTTVVRTTLEGLVAKNQAQRTKQGTSVYYTATETPASEPKQEPAAGTQSARNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJS0</accession>
    <name>Q9RJS0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0416</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624737.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027098.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0416"/>
    <dbReference type="GeneID" id="1095839"/>
    <dbReference type="KEGG" id="sco:SCO0416"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.392"/>
    <dbReference type="eggNOG" id="COG3371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067784_0_0_11"/>
    <dbReference type="OMA" id="PPWAFRR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176910" evidence="2">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="20418" checksum="DDB2B088CADA7A43" modified="2000-05-01" version="1">MRFVPRWVLLSSGCAPVLLIAGWTGAAYAEGASYDPVSQTISVLGAYGAAGFWVMTAAFLALGVCHLLTAWGLRPAATAGRVALGGGGLAALVLVALPAPSSGGSLRHGAVVVVGFTLLAVWPVLAVNGGPAGPWALRLAPSIAVTTLMAAGGVWFLIEMRQHGDAGVAERVVTSLQSLWPFVVAASCLRHARRPGTAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJU7</accession>
    <name>Q9RJU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0363</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624686.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027054.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0363"/>
    <dbReference type="GeneID" id="1095786"/>
    <dbReference type="KEGG" id="sco:SCO0363"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.339"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059918_0_0_11"/>
    <dbReference type="OMA" id="WALPIDA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB55725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="369" mass="39350" checksum="F12CFB6607EA641B" modified="2000-05-01" version="1">MTHIGAPYRGLTWDHPRGYDALAACAGGLVHWDVQPLEGFESHPVDELCARYDLVVLDHPHLGEAVVTGCLRPLDDLFTPAELARWGAGSIGPTMRSYAMDGRQWALPLDAATQVAATRTDLVGEPPGTWDEVRRLARRAPVALSLAGPHAFLTFASVALAVGEEPAADPDQLIGDGTGLAVLDLLADLDALAPPGTRELNPIGLLELMAGTDRLAHCPLVYGYVTYADRLTFTDAPAVTAGGRPGSTLGGAGIALSARCVPSPELLAHMRWLMSPEAQGDFLPRHSGQPSARTAWTSPKTVAADFYRRTAATCEQAWVRPRHAGYIGFQTAASAAVRAALAGETGHREALDRMRALYRTSRTAKEPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJW4</accession>
    <name>Q9RJW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0346</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624669.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027038.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0346"/>
    <dbReference type="GeneID" id="1095769"/>
    <dbReference type="KEGG" id="sco:SCO0346"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.320"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_4_11"/>
    <dbReference type="InParanoid" id="Q9RJW4"/>
    <dbReference type="OMA" id="EEPDFFI"/>
    <dbReference type="PhylomeDB" id="Q9RJW4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="31453" checksum="AFE1433C03AC7B83" modified="2000-05-01" version="1">MKLVRLGDPGRERPAVIDDRGVTRDLSSLTSDIDGAFLAADGIARTRRALADDVLPPLRTEGLRFGPPVARPGAVVCIGQNYAAHAAESGSEPPTRPVIFFKPPNTVVGPNDEVEIPRGSARTDWEVELAVVIGRTARYLDSPGQALEHVAGYAVSNDVSERDFQLEHSGGQWSKGKSCATFNPLGPFLVPADEVPDVQALRLRSFVNGEPRQDSRTADMIFSVAQLVYDLSQYLVLDPGDVINTGTPEGVALSGRFPYLRPGDVMEIEIEGLGRQRQALVPARTSSQSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK22</accession>
    <name>Q9RK22_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0484</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36402">
        <property type="entry name" value="T36402"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624801.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978381.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0484"/>
    <dbReference type="DNASU" id="1095907"/>
    <dbReference type="GeneID" id="1095907"/>
    <dbReference type="KEGG" id="sco:SCO0484"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.463"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RK22"/>
    <dbReference type="OMA" id="DRPIFAL"/>
    <dbReference type="PhylomeDB" id="Q9RK22"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="41291" checksum="7D8F0B8514B3410D" modified="2000-05-01" version="1">MNSPTPAAARISIIGAGPGGLTCARVLRRHGIAVTVYDRDPDAASRDQGGSLDLHEEDGQLALREAGLLEEFFALARCESQEERRFDTAGRLLGRRLPDEGETARPEIDRGQLRGLLLESLDAGTVRWGHGLESVSGPAEGPRTLTFTDGSTVETDLVIGADGAFSRVRAAVSDAVPRYTGVGFLEAWFDDMESAHPELSELVGRGSAHVADGQRGLFAQRNSGGHMRVYVMRRVALDWMTASGLRPDDTDGIRARLLAEYAGWSPRILRMITENDGPYVDRPLFALPVPHTWRPTPGVTLLGDAAHLMPPLGVGVNLAMLDGAELALALAASATVDDAVRTYEKTMLPRSAEIAGMLEGGAGFLLEEPDAEDLARLGAPGADGGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKC0</accession>
    <name>Q9RKC0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3167</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627383.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975649.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3167"/>
    <dbReference type="GeneID" id="1098601"/>
    <dbReference type="KEGG" id="sco:SCO3167"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3227"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_25_3_11"/>
    <dbReference type="InParanoid" id="Q9RKC0"/>
    <dbReference type="OMA" id="HQFLDQR"/>
    <dbReference type="PhylomeDB" id="Q9RKC0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="22248" checksum="8E9003F1767D8441" modified="2000-05-01" version="1">MTETATARRSRITPEREAELYEAVLDLLREVGYDALTMDAVAARTRSSKATLYRQWGGKPELVVKAIRHNKPGEIGDVDTGSLRGDLHALMVREDDCTMEQNSALMRGVAMALHQNPDLRQAFREQLIEPEMAEFQRVLQRAVDRGEIRADCPALDFLVHMMVGGFATRTLLDDQPPTREFLASYIDAVILPALGVSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKR7</accession>
    <name>Q9RKR7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50570">
        <property type="entry name" value="T50570"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626509.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976551.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2261"/>
    <dbReference type="GeneID" id="1097694"/>
    <dbReference type="KEGG" id="sco:SCO2261"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2298"/>
    <dbReference type="eggNOG" id="ENOG502ZDRZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192325_0_0_11"/>
    <dbReference type="OMA" id="SSNMCWY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="85" mass="8913" checksum="DD42ADB18CA841AA" modified="2000-05-01" version="1">MRRWGTLVGTSVPPTGAVPMPRLALYALVVCVLAVAAAVVSFVQGSVVIGVVWVLLSGLSSNMCWYYAKRGRDARRAASSTSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL06</accession>
    <name>Q9RL06_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0312</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624639.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027007.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0312"/>
    <dbReference type="GeneID" id="1095736"/>
    <dbReference type="KEGG" id="sco:SCO0312"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.287"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_3_5_11"/>
    <dbReference type="InParanoid" id="Q9RL06"/>
    <dbReference type="OMA" id="ERACCFS"/>
    <dbReference type="PhylomeDB" id="Q9RL06"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="136"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="240"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB55669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="389" mass="42469" checksum="FF20581C74B53EF6" modified="2000-05-01" version="1">MPFTLTPRYDDNPRLEELVGRLRAYLTDELLPYERAHGITPESKLDRATLESVWKRSAELGFYGISLPPELGGQGLSFTELCALKEELTSSGAALSHSVLGDMGGPLRVGAIVKYATDEQRERYLLPVVRGERACCFSLTEQDAGSDVRRMRTTATPDGDSYVLNGHKVFSSAAPFADFAVVVARMADSEETYSAFLVDLDTPGCRVLDGAVPMSGQQMEGDLVFEDCRVPVANLLGEIGQGLRIGIGRITLNRLLHCPSLIGAARRAWDLSVDHAKTRVAFGQPLLALQAIQHKLADMATDLYAARSMVQATAAKADRGENIAVEANMCKLFTAEACFRTADQAVQIHGKDGLTRGHEVEQIFRSLRMFRIVTGTTEIHKNAIVKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL10</accession>
    <name>Q9RL10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624635.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027005.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095732"/>
    <dbReference type="KEGG" id="sco:SCO0308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.283"/>
    <dbReference type="eggNOG" id="ENOG502ZUBW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612385_0_0_11"/>
    <dbReference type="OMA" id="WLATTCF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="467" mass="50537" checksum="43BABFB25E1BB69A" modified="2000-05-01" version="1">MPRSDAAVRVRTRLLLMYHLTPQVHVPDDRLRPLSEALGLGRFTAHVEAAGLLLPRLVLHERVREITLPPNAARVDGADITLAVTPRQDPLLFVDVEVPDEAGDSDTIAETLYATWQDRSAIRVGGVPLTAWLDERLRAYGLTDRTADRPPLAFGRNVHQSVFPGAALAGRLLAAHVPGDAVGQDVVTIVLRGTLDSGTGATLGIRRPETLNNAGQTMVAHGRGVSLIVGYAPPVENAFGLAAAGILTAVAAVHRIRRQAFAALELDRAAAVETTDAARALVAQLSHRLNDLQLDLSFSVEVYADTILVPELLVESFHASLRDVSSLADALANTSRIVERVNAVLATRRVGLETAAQQYAEDRDRVLAAVIAAGSLLALPPALLLAYFGVNSSDVDPSRSILDFQHYGVAYAIAWSPFLLLILVGLLARRRISLRLPAPDAATSERRTRRFRRSLRSWLGRSRRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1R7</accession>
    <name>Q9S1R7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0224</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37139">
        <property type="entry name" value="T37139"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624556.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026939.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0224"/>
    <dbReference type="GeneID" id="1095648"/>
    <dbReference type="KEGG" id="sco:SCO0224"/>
    <dbReference type="eggNOG" id="ENOG5032R1X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072323_0_0_11"/>
    <dbReference type="OMA" id="AHALGYW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="345" mass="36929" checksum="23643009936285B8" modified="2000-05-01" version="1">MGTDGTLDEALERLYRTGPEFGGRLSNHGPMAVESMVRRGHARQVHRWLDLYMRRLDERPRGGCPIPAVGWRSALGDPRRLGDWLAFFDREVTEQPWRAVLEVWWPRLVPGIAAGATHGVIRTGHAVHALLAHEDGPRLAELGQALGYWAARWQQVPSAAPSGTSGPASALAGVPRIADQSADIDHRLGQLTGLSGWPAALAALRPAADAGQARDLLAGLTTAAAVRYLPNAHGSPVMLIHSATAPMAVLRTLPALPSTQWVVSLHAAWAASAAVTAAYAPAAPLPRHALPTAHRSAEETFALAVRHQDEHVIKLADTCLDVHRRTGCPDALAAVTRAIELIDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1S2</accession>
    <name>Q9S1S2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0070</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37134">
        <property type="entry name" value="T37134"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624424.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0070"/>
    <dbReference type="GeneID" id="1095501"/>
    <dbReference type="KEGG" id="sco:SCO0070"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219126_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9S1S2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="24687" checksum="66435CF4D0E35D62" modified="2000-05-01" version="1">MSGTQTVLSAAASSRRLKRLVFVSSASVYGYGNPDDWAGPEDEHRSVRELLSSVYGRMPPQFGEERRLRPLSVYANTKAFGEVQTDLILRPAGISYSVVRYFSVYGQPQVIKPGSHSWVVAWFADRAAAGLPLHLNGGGHQVRDFVRVDDIAEGTLRALTEPAADRKTVNITGAGPRSRWRRPAPGPARSGRRRTAGRGCPAAGFRQPASAARARSGRAPWPTRPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S270</accession>
    <name>Q9S270_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc-binding alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB46780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36783">
        <property type="entry name" value="T36783"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625956.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027915.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1682"/>
    <dbReference type="GeneID" id="1097113"/>
    <dbReference type="KEGG" id="sco:SCO1682"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1699"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_11"/>
    <dbReference type="InParanoid" id="Q9S270"/>
    <dbReference type="OMA" id="GVFHNTP"/>
    <dbReference type="PhylomeDB" id="Q9S270"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="191"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="358" mass="36837" checksum="1F589D2AF1661B97" modified="2000-05-01" version="1">MSAGERVPEEFVPGCVIHGAGDLRVTDVPVRPPGPGEALVAVRYGGVCGSDLHYWRHGGVGDFHLREPMLLGHEVVGTVVAYGSPDTPGPAAGTSVAVHPATPCGVCPECVDRRRNVCRDTRYLGSAARFPHVQGGFAARIVVPAGQLRPLPAGLDPRRAALAEPLSVALHAVRRAGDPAGRHVLVTGAGPIGCLVVAAAKAAGAAHVTVTDLLPAALEYARAAGADTLVRADDPDDAGWPVEVDTAVEASGVAAGLDTCLRLVRRGGVVVQLGMLPPGQSPFAGNLLVSREIELRGAFRFDGEFDDALRLLAAEPAFDALVSAVVPVRDAASAFELAADRSRSCKVLLDFGAAPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2R2</accession>
    <name>Q9S2R2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2174</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35290">
        <property type="entry name" value="T35290"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626427.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2174"/>
    <dbReference type="GeneID" id="1097607"/>
    <dbReference type="KEGG" id="sco:SCO2174"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2211"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056710_0_0_11"/>
    <dbReference type="OMA" id="FPYTSFD"/>
    <dbReference type="PhylomeDB" id="Q9S2R2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB51258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="28450" checksum="7EB611F2B0E0ACBA" modified="2000-05-01" version="1">MPGMSYVPAYVSCREPLVSATSAPSVPPVPPYGPYREDCPWCGSRRLRARLRGDGPRQGAPHRSPVERCADCRHVFRNPPLTPGPEHPLVRAGVRFRHRLAARALYRHCPEPESWLDVGTGDAEFPRTARTHFPYTAFDGLDATHRVLRARAVERVEEAFVGRLTDPHIAARLRERYDVVSLFQYLERVVDPRAELRAALRVLRPGGHLLVDVADPRRLLPVHPLGLGAELVAQGCTVLTGSRGHRVVARKDGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2S9</accession>
    <name>Q9S2S9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2060</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35089">
        <property type="entry name" value="T35089"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626320.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028122.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2060"/>
    <dbReference type="GeneID" id="1097494"/>
    <dbReference type="KEGG" id="sco:SCO2060"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2092"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080689_0_0_11"/>
    <dbReference type="OMA" id="AYASFTV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="81"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB51452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="306" mass="31171" checksum="90D19A35F200FA28" modified="2000-05-01" version="1">MRTPAAASVPVGASAPARATASNDPSEGELRDVSVVPADALRGAAPAAEGRRAAGPAALGPKARLWPSLVAVYRAQLSRARVARIPLLFVATFQSVGIMILMRGVVDGGGEARAVVAGSAVLVVAFVALNLLAQYFGQLRASGGLDHYATLPVPPAAVVLGAAGAYASFTVPGTVVTAVFGCLLFGLPMTHLWVLVAVIPLAGAALAGLGAALGLLAPRPEFATLLGQLGMSAALLLGVLPPERMPQVVRLARDLLPSTYGVEAFARTFGERPDWGFVLGDLAVCAAVGVISLAVATWAYRRAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7R7</accession>
    <name>Q9X7R7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7283</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35325">
        <property type="entry name" value="T35325"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631339.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031563.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7283"/>
    <dbReference type="GeneID" id="1102721"/>
    <dbReference type="KEGG" id="sco:SCO7283"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7385"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069623_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7R7"/>
    <dbReference type="OMA" id="WTFGESS"/>
    <dbReference type="PhylomeDB" id="Q9X7R7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="136"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="28594" checksum="E96138C195265A3D" modified="1999-11-01" version="1">MAVQPQGAPCWADAMFTDVEGAKSFYGDVLGWTFGESSTEFGNYTQCYADGKAVAAVVPPPPGHEDQSQWCLYFASPDAAATAGRIREAGGELLLEPMKVGDFGTMCLARDPSGVVFGVWQGDEHEGFEATAVPGAYCWAEVFTREPAKSDAFFPAVFSYRARQMQDDQVDFRLFDLGDDPVLGRMAMTEDFPPEVPPHINVYFTVGDCDAAVARATERGGMLRFGPVTTPFGRFAALSDPQGASFSVIDITTTEGEMPEVTDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X801</accession>
    <name>Q9X801_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO2142</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35524">
        <property type="entry name" value="T35524"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626398.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028162.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2142"/>
    <dbReference type="GeneID" id="1097576"/>
    <dbReference type="KEGG" id="sco:SCO2142"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2177"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="InParanoid" id="Q9X801"/>
    <dbReference type="OMA" id="VIFERFR"/>
    <dbReference type="PhylomeDB" id="Q9X801"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="244"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="454" mass="49976" checksum="9B460D5BF505C024" modified="1999-11-01" version="1">MAVALASVAATTRSILLRDTDQRINGLLAQEAGEFANFEEQGFDPETGRPFTDPGRLLRVFLERQYADLDEELVGLVGEVGSRPTQIIQQREIPVGRPLHEDADARRRIYASPDSTGTLERPEGEIRWAKVTVARYGGEPAAAFVVAFHPGREQARADEVFRVLLAISGVALLMTTGIAWVVAGRILKPVRLVRTTAAQLTEQDLTRRIPVHGHDDVAALAETFNAMLDRLERAFATQRRFVDDAGHELRTPITIVRGHLELMGDDPAEREETVRLVTDELDRMSRIVEDLLLLAKAERPDFVTPEPVQLAELTADVFVKARTLGEREWVLDGVADREVHLDPQRITQAMVQLAQNAVQHTTAGQRVRIGSRADGWRIELYVADSGPGVQPQDAEVIFERFRRGTARRGVRGTGAGLGLSIVRAIAEGHGGRVDLRTTAGGGATFVLTLEEARP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X814</accession>
    <name>COX2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable cytochrome c oxidase subunit 2</fullName>
            <ecNumber>7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytochrome c oxidase polypeptide II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Mtb92</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ctaC</name>
        <name type="ordered locus">SCO2156</name>
        <name type="ORF">SC6G10.29c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds a copper A center.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35538">
        <property type="entry name" value="T35538"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626412.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028168.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X814"/>
    <dbReference type="SMR" id="Q9X814"/>
    <dbReference type="STRING" id="100226.SCO2156"/>
    <dbReference type="TCDB" id="3.D.4.4.5">
        <property type="family name" value="the proton-translocating cytochrome oxidase (cox) superfamily"/>
    </dbReference>
    <dbReference type="PRIDE" id="Q9X814"/>
    <dbReference type="GeneID" id="1097590"/>
    <dbReference type="KEGG" id="sco:SCO2156"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2191"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036876_3_0_11"/>
    <dbReference type="InParanoid" id="Q9X814"/>
    <dbReference type="OMA" id="HAFMPIA"/>
    <dbReference type="PhylomeDB" id="Q9X814"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000006063" description="Probable cytochrome c oxidase subunit 2">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>A</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="319" mass="35447" checksum="EC266914F4DFA79C" modified="1999-11-01" version="1" precursor="true">MSPNGSDRSPRRPMRRKLLQALTAGLVLATATGCTYEDFPRLGMPTPTTEEAPRILSLWQGSWAAALATGVLVWGLILWSVFFHRRSRTKVEVPPQTRYNLPIEALYTMVPLVIVSVLFYFTARDESDLMSLNKKPDLTVNVVGFQWSWCFNHIEDVPGSTGDAKTSKELAGIPDRFIEDFPANAGGVYDCGTPGTENPQTGNPGPTLWLPKGKTVRFVLTSRDVIHSFWVVPFLMKQDVIPGHTNAFEVTPNKEGTFLGKCAELCGVDHSRMLFNVKVVSPERYEQHLQDLAKKGQTGYVPAGIAQTSHEKNRETNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X831</accession>
    <name>Q9X831_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable ABC transport permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6064</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35856">
        <property type="entry name" value="T35856"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630173.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030627.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6064"/>
    <dbReference type="GeneID" id="1101505"/>
    <dbReference type="KEGG" id="sco:SCO6064"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6165"/>
    <dbReference type="eggNOG" id="COG1174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_7_1_11"/>
    <dbReference type="InParanoid" id="Q9X831"/>
    <dbReference type="OMA" id="FSDGAHW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB41557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="23050" checksum="A6CD3ABAB307CACA" modified="1999-11-01" version="1">MNVLDFVNAFFSDSAHWHGYDGIPTRLLEHVQYTLMALGLAAAIGLPVGLLTGHTGRGGNAVAFVATAARALPSFGLLVLIAVVVGIGLLPVMVPLVVLAVPPILVTTYEAVRSVDPSPVDAARGMGMHESGILFRVELPVALPLVLSGLRSAAIQVVSTATIAAYVSLGGIGRYIIDGLYQRDYEKVVGGATLVAVLALVTLALFWAAGRFAVSPGVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G1</accession>
    <name>Q9X8G1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ordered locus">SCO3337</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36286">
        <property type="entry name" value="T36286"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627546.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028917.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3337"/>
    <dbReference type="GeneID" id="1098774"/>
    <dbReference type="KEGG" id="sco:SCO3337"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3397"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8G1"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="PhylomeDB" id="Q9X8G1"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="174"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="284" mass="29806" checksum="291D9889EB4AB115" modified="1999-11-01" version="1">MTPDHAHTPEGTEPMTQKVAVLGTGKIGEALLSGMIGAGWAPADLLVTARRRERADELRARHGVTPVTNAEAAKAADTLILTVKPQDMGTLLDELAPHVPADRLVISGAAGVPTSFFEERLAPGTPVVRVMTNTPALVDEAMSVISAGTHATAAHLTHTEEIFGAVGKTLRVPESQQDACTALSGSGPAYFFYLVEAMTDAGILLGLPRDKAHDLIVQSAIGAAKMLRDSGEHPVKLRENVTSPAGTTINAIRELENHGVRAALIAALEAARDRSRELATGTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Z4</accession>
    <name>Q9X8Z4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3712</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36647">
        <property type="entry name" value="T36647"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627904.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029182.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3712"/>
    <dbReference type="GeneID" id="1099148"/>
    <dbReference type="KEGG" id="sco:SCO3712"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3773"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_2_2_11"/>
    <dbReference type="InParanoid" id="Q9X8Z4"/>
    <dbReference type="OMA" id="VLFHNNA"/>
    <dbReference type="PhylomeDB" id="Q9X8Z4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="92"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB44415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="29155" checksum="49584524EC1B5446" modified="1999-11-01" version="1">MVPDATGTGGEQLREGGAADMARHGGGRGWYGKVVGAALGVTMLAVGASVWTAQADSVGGGPTPRASASATPGGEAKPVDVSIAHASDAGPNGVNITIDDGPDPAWTPQVLDLLEEYGVKATFCMTGLQAEAHPDLVKDVVAAGHRLCDHTVSHDTAMDKKSEAYQAKEILDAERMIIEASGGVRPVYYRAPGGAFTPYSRKLAASHGMRPLGWNVDTKDFERPGSDAIVATVKRELSNGPTILFHDAGGDRTQTVEALRQVLPWLKEQGRTFGFPVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-08" modified="2022-08-03" version="152" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Z9</accession>
    <name>KDPB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="1">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpB</name>
        <name type="ordered locus">SCO3717</name>
        <name type="ORF">SCH35.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:16778"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="1"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36652">
        <property type="entry name" value="T36652"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627909.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029187.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8Z9"/>
    <dbReference type="SMR" id="Q9X8Z9"/>
    <dbReference type="STRING" id="100226.SCO3717"/>
    <dbReference type="GeneID" id="1099153"/>
    <dbReference type="KEGG" id="sco:SCO3717"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3778"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X8Z9"/>
    <dbReference type="OMA" id="KSPVMFV"/>
    <dbReference type="PhylomeDB" id="Q9X8Z9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000046145" description="Potassium-transporting ATPase ATP-binding subunit">
        <location>
            <begin position="1"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="707" mass="74161" checksum="00E91CFB923E1180" modified="2003-01-17" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X915</accession>
    <name>Q9X915_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3550</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36671">
        <property type="entry name" value="T36671"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627748.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3550"/>
    <dbReference type="GeneID" id="1098986"/>
    <dbReference type="KEGG" id="sco:SCO3550"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3606"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_11"/>
    <dbReference type="InParanoid" id="Q9X915"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="PhylomeDB" id="Q9X915"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="322"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="815" mass="87724" checksum="582999636F826E09" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBI8</accession>
    <name>Q9ZBI8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transport associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6486</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35973">
        <property type="entry name" value="T35973"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630569.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030957.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6486"/>
    <dbReference type="GeneID" id="1101925"/>
    <dbReference type="KEGG" id="sco:SCO6486"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6587"/>
    <dbReference type="eggNOG" id="COG2362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086038_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBI8"/>
    <dbReference type="OMA" id="ATGVTWP"/>
    <dbReference type="PhylomeDB" id="Q9ZBI8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="29532" checksum="D7429DAF5F8AD520" modified="1999-05-01" version="1">MKILISADMEGATGVTWPADVLPGTPQWERCRSMFTSDVNAAVLGFFDGGADEVLVNEAHWSMRNLLLERLDERTEMLTGRHKALSMVEGVQHGDVDGIAFIGYHAGAGMEGVLAHTYLANQLTGVWLNDVRASEGLLNAHVVAEYGVPVVLVTGDDVACEDALGYAPEARKVAVKDHVSRYAAVCRTPARTAADIRAAAKEAAALAVRHEPVGGGPFTLAMEFDAEHLAAAATVVPGVAQVGERKVAYTHETMFEAIRTFKAVTTIVSAAVEEQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBP2</accession>
    <name>Q9ZBP2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline rich protein (Putative membrane protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6167</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35474">
        <property type="entry name" value="T35474"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630271.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030704.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6167"/>
    <dbReference type="GeneID" id="1101608"/>
    <dbReference type="KEGG" id="sco:SCO6167"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6276"/>
    <dbReference type="eggNOG" id="ENOG502ZGUI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599795_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="456" mass="50032" checksum="1293F4A97256AC57" modified="1999-05-01" version="1">MAPPVGSLARPRCRVGLLVPPGCWVPRVPVVRPWDGGGPARGVARSAAAPGRPWSGGARARHFGARPPTPGDRRRQYRPPHGNRLPEPVPGPRHRHQQRRGTPAVGTGPEAPASTTRRAGPAPAVRRAGHRSPRPTGPDRKHRTCFSRQPSPSPVSVARASSPSRPRPCPPPVPVPRPRPVHDPPPAPAPFLVRPPPPPRPYGRRPPRRRPYPVSHVVTRPDPTRSDPIRPDNRPVPGRRHPVAGEIPQAQPPPAVPDPDRERYPYLLLWRWRRNPLRRPSDRLRAWVSLGLVLAVLGAAPAAMFGVGDSAYRHYRSTAEHEARTRDHRPAVLTHDAPRHPEPGSDEAKKTRYPVPVRFTGPDGASRTGRTEVEPGLPADSTVLVWVDDQGRITEPPLTAEQIRSRTMGWAILAFLGVVVTGLAAHAATGLVLHRRNLAQWDAAWANTAPRWSRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBT5</accession>
    <name>Q9ZBT5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6153</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34666">
        <property type="entry name" value="T34666"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630258.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030691.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6153"/>
    <dbReference type="GeneID" id="1101594"/>
    <dbReference type="KEGG" id="sco:SCO6153"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6258"/>
    <dbReference type="eggNOG" id="COG1378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056943_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBT5"/>
    <dbReference type="OMA" id="VDRVPTK"/>
    <dbReference type="PhylomeDB" id="Q9ZBT5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="260"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="35032" checksum="ED12381C1F01BEE2" modified="1999-05-01" version="1">MLGVLGLEDTHEAAYRALVSVGAADVPDLARRLALGERDTERALRRLEQNGLAAQSSARPGRWVAAPPGVALGALLTQQRHELERAELAAALLAEEYRAAAAEPAVHDLVEVVTGAGAVAQRFLQLQLGASEEVCALVTDKPVAVTGMENDAEEQATGRGVRYRVVVERSVLDLPTGITELTAALGRDEQVRVVDRVPTKLIVADRSLALVPLTARSSEPAALVVHASGLLELLCGLFEAVWRDALPLRLGASGVTEQAPDGPDGTDLEILSLLLAGLTDASVAKQLDLGLRTVQRRVKRLMELTGVTTRLQLGWHAYERDWVARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBW1</accession>
    <name>Q9ZBW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative neuramidase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6557</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34999">
        <property type="entry name" value="T34999"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630638.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031005.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6557"/>
    <dbReference type="CAZy" id="GH33">
        <property type="family name" value="Glycoside Hydrolase Family 33"/>
    </dbReference>
    <dbReference type="GeneID" id="1101996"/>
    <dbReference type="KEGG" id="sco:SCO6557"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6661"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_430157_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBW1"/>
    <dbReference type="OMA" id="NSWYATG"/>
    <dbReference type="PhylomeDB" id="Q9ZBW1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177081" evidence="3">
        <location>
            <begin position="30"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="5">
        <location>
            <begin position="470"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="LAM_G_DOMAIN" evidence="4">
        <location>
            <begin position="470"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA22361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="648" mass="68216" checksum="F1CD5835276679EB" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O50515</accession>
    <name>PTHP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Phosphocarrier protein HPr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Histidine-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ptsH</name>
        <name type="ordered locus">SCO5841</name>
        <name type="ORF">SC9B10.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="Eur. J. Biochem." volume="265" first="308" last="317">
            <title>The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH.</title>
            <authorList>
                <person name="Parche S."/>
                <person name="Schmid R."/>
                <person name="Titgemeyer F."/>
            </authorList>
            <dbReference type="PubMed" id="10491187"/>
            <dbReference type="DOI" id="10.1046/j.1432-1327.1999.00727.x"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-19</scope>
        <scope>CHARACTERIZATION</scope>
        <scope>MUTAGENESIS OF HIS-15</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPr family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35877">
        <property type="entry name" value="T35877"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629964.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973180.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50515"/>
    <dbReference type="SMR" id="O50515"/>
    <dbReference type="STRING" id="100226.SCO5841"/>
    <dbReference type="TCDB" id="8.A.8.1.7">
        <property type="family name" value="the phosphotransferase system hpr (hpr) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101283"/>
    <dbReference type="KEGG" id="sco:SCO5841"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5938"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_3_2_11"/>
    <dbReference type="InParanoid" id="O50515"/>
    <dbReference type="OMA" id="RRVNVGW"/>
    <dbReference type="PhylomeDB" id="O50515"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000107882" description="Phosphocarrier protein HPr">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of phosphorylation." evidence="2">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="10491187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="93" mass="9391" checksum="6F72F379FEFFFF19" modified="2007-01-23" version="3">MAERRVNVGWAEGLHARPASIFVRAATATGVPVTIAKADGSPVNAASMLAVLGLGAQGGEEIVLASDAEGAEAALERLAKLVAEGLEELPETV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O50519</accession>
    <name>KITH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidine kinase</fullName>
            <ecNumber evidence="1">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdk</name>
        <name type="ordered locus">SCO5845</name>
        <name type="ORF">SC9B10.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35881">
        <property type="entry name" value="T35881"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629968.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973175.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50519"/>
    <dbReference type="SMR" id="O50519"/>
    <dbReference type="STRING" id="100226.SCO5845"/>
    <dbReference type="GeneID" id="1101287"/>
    <dbReference type="KEGG" id="sco:SCO5845"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5943"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_2_0_11"/>
    <dbReference type="InParanoid" id="O50519"/>
    <dbReference type="OMA" id="GTMDCGK"/>
    <dbReference type="PhylomeDB" id="O50519"/>
    <dbReference type="BRENDA" id="2.7.1.21">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0237">DNA synthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175029" description="Thymidine kinase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <sequence length="216" mass="23368" checksum="A04BA1CE8C3B4ADA" modified="1998-06-01" version="1">MPELVFFSGTMDCGKSTLALQIEHNRSARGLAGMIFTRDDRAGEGKLSSRLGLVTDAVEVGDGQDLYAHVVDHLSQGGRVDYVIADEAQFLAPDQIDQLARVVDDLDVDVYAFGITTDFRSKLFPGSQRLVELADRVEVLQVEALCWCGARATHNARTVGGVMVVEGAQVVVGDVAQSPDEIGYEVLCRRHHRRRMTSATARAAALSPDVLPVTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O54111</accession>
    <name>O54111_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5915</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34587">
        <property type="entry name" value="T34587"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630033.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973107.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5915"/>
    <dbReference type="GeneID" id="1101357"/>
    <dbReference type="KEGG" id="sco:SCO5915"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6012"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_7_1_11"/>
    <dbReference type="OMA" id="CISFTVE"/>
    <dbReference type="PhylomeDB" id="O54111"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18705" checksum="8770D6A0D3528709" modified="1998-06-01" version="1">MPHTCISFTVEATGAAVHRARHRVSTALSWWGGPVEEELRFSAELVTSELLTNGLRHAGGPMTVELTLVHDMVVVAVLDDSRELPRPRQTEADDECGRGLALIEDLSLIRGVETTSRGKRCWAVLPLRTPQERAIESAPAEEADHGFEADRERWSLAPQGSGLLASLFPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O69952</accession>
    <name>O69952_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34934">
        <property type="entry name" value="T34934"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630657.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031017.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6577"/>
    <dbReference type="GeneID" id="1102016"/>
    <dbReference type="KEGG" id="sco:SCO6577"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6682"/>
    <dbReference type="eggNOG" id="COG1099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061552_0_0_11"/>
    <dbReference type="InParanoid" id="O69952"/>
    <dbReference type="OMA" id="WAAFTIY"/>
    <dbReference type="PhylomeDB" id="O69952"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012022">
        <property type="entry name" value="UCP005295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42658">
        <property type="entry name" value="PTHR42658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005295">
        <property type="entry name" value="UCP005295_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="31356" checksum="45AF257C4A1B9AB0" modified="1998-08-01" version="1">MRIFDPHIHMTSRTTDDYEAMYAAGVRALVEPSFWLGQPRTSPDSFRDYFDALLGWEPFRAAQYGIAHHCTIALNPKEANDPRCRPVLDELPRYLVKDRVVAVGEIGYDSMTPAEDTALATQLQLAADHGLPALVHTPHRDKLAGLRRTLDAVRESALPTERVLVDHLNETTVKEAKDSGAWLGFSVYPDTKMDEARMVALLREYGPEQVLVNSAADWGRSDPLKTRKVGDLMLAEGFTDDDVDRVLWRNPVAFYGLSGRLELDVAAGDATHEGNSILRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O69968</accession>
    <name>O69968_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5792</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35112">
        <property type="entry name" value="T35112"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629916.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030457.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5792"/>
    <dbReference type="GeneID" id="1101234"/>
    <dbReference type="KEGG" id="sco:SCO5792"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5882"/>
    <dbReference type="eggNOG" id="ENOG5033WX3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112928_0_0_11"/>
    <dbReference type="OMA" id="CCAAGWG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA18329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="17555" checksum="873F64E2714C9E3C" modified="1998-08-01" version="1">MAMEAGPRDTAPSTEHGTADHGGPEPDGGALSPDGPDETPDGVADGPAPAEMYGAEVEVELRPQRRLRIWQLAPIVCLAALGSLMFAFPLAFDFGDSGAVIAMLGLLICSCAAGWGMMAARRVGYTWPGLPQRGSGRRADWRTILVYALAVAAVVVLAVWRVARLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O69975</accession>
    <name>O69975_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5799</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35119">
        <property type="entry name" value="T35119"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030463.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5799"/>
    <dbReference type="GeneID" id="1101241"/>
    <dbReference type="KEGG" id="sco:SCO5799"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5890"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="InParanoid" id="O69975"/>
    <dbReference type="OMA" id="NLMPGVQ"/>
    <dbReference type="PhylomeDB" id="O69975"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="532" mass="53555" checksum="B6749EC15B162315" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O86503</accession>
    <name>O86503_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5521</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29051">
        <property type="entry name" value="T29051"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629655.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030289.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5521"/>
    <dbReference type="GeneID" id="1100961"/>
    <dbReference type="KEGG" id="sco:SCO5521"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5608"/>
    <dbReference type="eggNOG" id="ENOG5031W5V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210476_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="43" mass="4791" checksum="BF4D986331FEAE83" modified="1998-11-01" version="1">MAETTVRRRVRHLSRTSDSDRKNAAAALQRSLDRRDNGGATGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O86564</accession>
    <name>SDHL_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>L-serine dehydratase</fullName>
            <shortName>SDH</shortName>
            <ecNumber>4.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>L-serine deaminase</fullName>
            <shortName>L-SD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sdaA</name>
        <name type="ordered locus">SCO5469</name>
        <name type="ORF">SC2A11.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAA20172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34749">
        <property type="entry name" value="T34749"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629605.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030269.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86564"/>
    <dbReference type="SMR" id="O86564"/>
    <dbReference type="STRING" id="100226.SCO5469"/>
    <dbReference type="GeneID" id="1100909"/>
    <dbReference type="KEGG" id="sco:SCO5469"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5553"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_11"/>
    <dbReference type="InParanoid" id="O86564"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="PhylomeDB" id="O86564"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000171911" description="L-serine dehydratase">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="455" mass="48601" checksum="3FE9DD03EEC4A526" modified="1998-11-01" version="1">MAISVFDLFSIGIGPSSSHTVGPMRAARMFARRLRNEELLDSVASVRVELYGSLGATGHGHGTPKAVLLGLEGDSPRTVDVESADDRVETIKSSGRISLLGDHEIAFAYDDDMVLHRRKALPYHANGMTLWAYDAEGAEVLTKTYYSVGGGFVVDEDAVGADRIVLDDTVLKYPFRTGDELLRLARETGLSISALMLENERAWRDEDEIREGLLEIWRVMRACVDRGMTREGILPGGLKVRRRAANTARKLRSEGDPQALAMEWITLYAMAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYMNFVPGADEDGVVRFLLAAGAIGMLFKENASISGAEVGCQGEVGSACSMAAGALAEVLGGSPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCIERNGMAAVKAVTAARMAMRGDGSHKVSLDKVIKTMKETGADMSVKYKETARGGLAVNIIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O86569</accession>
    <name>O86569_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5474</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAA20177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34754">
        <property type="entry name" value="T34754"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629610.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973524.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5474"/>
    <dbReference type="GeneID" id="1100914"/>
    <dbReference type="KEGG" id="sco:SCO5474"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5558"/>
    <dbReference type="eggNOG" id="ENOG502Z89T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089527_0_0_11"/>
    <dbReference type="InParanoid" id="O86569"/>
    <dbReference type="OMA" id="RLFEPDW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="144"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="27182" checksum="A0CA1B3D1D54E704" modified="1998-11-01" version="1">MDFPAQTHPHPHGGWPGNELEEVLSASLGIPSAGGRIVEVLGRSFLWVPLPNGGGPHSGPLDLPSLEIDGQAYVPVFSSEEQLRQVAGAHMAYTIAPAAEFARGLPPQVGIAVNPEGVVGIPLPPPAVAELCRAGRTPLDGPSSGGRVRLFEPDWQDDPVDFLAAASAEFAATGVVRSARRCLAAVETADPVLFVGVELTHWEGDARTLPLDALGRALAKSPLKYQVNLVLLEAAQDPVCDWMRERVRPFYDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O86604</accession>
    <name>O86604_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6335</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29421">
        <property type="entry name" value="T29421"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630427.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030836.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6335"/>
    <dbReference type="GeneID" id="1101776"/>
    <dbReference type="KEGG" id="sco:SCO6335"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6447"/>
    <dbReference type="HOGENOM" id="CLU_915015_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="304" mass="32814" checksum="AA59E368D0230004" modified="1998-11-01" version="1">MPPAEPVRIRVRRPRRYFFGTCPKASWTAVMWSDAVFEPALPGLSSAATGSRCRPVRGRRPPSGARRSASRWVRRRPPCQSPPCWAWTHRPQGRQPSGSPSDGLPRTAHTSRRCPPACAQSRRGRTRMKRPACSRRGMPVGDPEDPANSGLEPNPPVPRSSTSLSCACPASRKRSPEWAAEIAFLACPRAGLEALPVRMPGRLPGAILVPAAGRRLPRFPGSRQILRPTTVAARSPPGGGVTMRCWSACSGVSVILSPVGAKVGALRTLGPDVPFLHGLAVKTRLAVSKRRFRPEYADGPGSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O88057</accession>
    <name>O88057_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36832">
        <property type="entry name" value="T36832"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625873.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027873.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1597"/>
    <dbReference type="GeneID" id="1097028"/>
    <dbReference type="KEGG" id="sco:SCO1597"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1609"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_1_11"/>
    <dbReference type="InParanoid" id="O88057"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="PhylomeDB" id="O88057"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="29367" checksum="225FFBCF9D89AEF5" modified="1998-11-01" version="1">MRPVSPELISPRSPRVAAARRLGKRNFRGKERLFLAEGPQAVREAAGYGDMLVELFATVEAAERYADIVGAAREVGARVHLAADAVIEDISTTVTPQGLVGVCRFLDTPFDEILAARPKLVAVLAHVRDPGNAGTVLRCADAAGAEAVVLTDASVDLYNPKAVRASVGSLFHLPVAVGVPVERAVAGLREAGVRVLAADGAGEDDLDTELDAGTMGGPTAWVFGNEAWGLPEETRALTDAVLRVPIHGKAESLNLATAAAVCLYASARAQRAAGGCRSVTES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>P72396</accession>
    <name>MALR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>HTH-type transcriptional regulator MalR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Maltose operon transcriptional repressor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">malR</name>
        <name type="ordered locus">SCO2232</name>
        <name type="ORF">SC10B7.27</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Mol. Microbiol." volume="23" first="537" last="549">
            <title>Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacl-galR family of regulatory genes.</title>
            <authorList>
                <person name="van Wezel G.P."/>
                <person name="White J."/>
                <person name="Young P."/>
                <person name="Postma P.W."/>
                <person name="Bibb M.J."/>
            </authorList>
            <dbReference type="PubMed" id="9044287"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1997.d01-1878.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Transcriptional repressor of the maltosaccharide utilization operon malEFG.</text>
    </comment>
    <dbReference type="EMBL" id="Y07706">
        <property type="protein sequence ID" value="CAA68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626483.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976582.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P72396"/>
    <dbReference type="SMR" id="P72396"/>
    <dbReference type="STRING" id="100226.SCO2232"/>
    <dbReference type="GeneID" id="1097665"/>
    <dbReference type="KEGG" id="sco:SCO2232"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2269"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="InParanoid" id="P72396"/>
    <dbReference type="OMA" id="HSEFVFM"/>
    <dbReference type="PhylomeDB" id="P72396"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00356">
        <property type="entry name" value="HTH_LACI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000107970" description="HTH-type transcriptional regulator MalR">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00111"/>
        </source>
    </evidence>
    <sequence length="344" mass="36351" checksum="CAC084B6C5E32E26" modified="1997-07-01" version="2">MTTRLADIAAQAGVSEATVSRVLNGKPGVAATTRQSVLAALDVLGYERPVRLRQRSEGLVGLITPELENPIFPALAQVIGQALTRQGYTPVLATQTPGGSTEDELTEMLVDRGVAGIIYVSGLHADTTADMQRYERLRAQGVPFVLVDGFSSQVQAPFISPDDRAAMSLAVTHLVSLGHTRIGLALGPKRFVPVQRKIEGFVRTVQDQLGLSAETVEKELVQHSLYTLEGGQAAASALIGRDCTAVVCASDMMALGAIRAARQLGLDVPKDVSVVGFDDSPLIAFTDPPLTTVRKPVPAMGQAAVRTLLEEIGGTPAPHSEFVFMPELVVRGSTASAPGERGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKP6</accession>
    <name>Q7AKP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626455.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028194.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2203"/>
    <dbReference type="GeneID" id="1097636"/>
    <dbReference type="KEGG" id="sco:SCO2203"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2241"/>
    <dbReference type="eggNOG" id="ENOG5031PZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099871_0_0_11"/>
    <dbReference type="InParanoid" id="Q7AKP6"/>
    <dbReference type="OMA" id="FPVWGAP"/>
    <dbReference type="PhylomeDB" id="Q7AKP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB90850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="20841" checksum="16D69C6478091EC3" modified="2012-05-16" version="1">MGLLDILLGRSRAVGPDLDRLFALPSAAVGLEAAAGFRPTGQGAVCFATVEGAAFERTHREIRALLDADAGRTPVEPTHDSYGYSWLVSQRSPDELPLLVNDLHAVNSTLEAGGFGPRLLCSLAGFVDDEGRRLALVYLYKRGTFYPFAPLPGERRRRDNALELRVRAVLGDELPVEGDLGRWFPVWGAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJN1</accession>
    <name>Q8CJN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6412</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAD55516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34906">
        <property type="entry name" value="T34906"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733700.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030898.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6412"/>
    <dbReference type="GeneID" id="1101851"/>
    <dbReference type="KEGG" id="sco:SCO6412"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6512"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="InParanoid" id="Q8CJN1"/>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="PhylomeDB" id="Q8CJN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="427" mass="45804" checksum="1C37775DED38FB43" modified="2003-03-01" version="1">MTRDLFARHRAVLPDWLALYYEDPLEITHGEGRYVWDAAGNKYLDFFGGILTTMTAHALPEVTKAVAEQAGRIVHSSTLYLNRPMVELAERVAQLSGIPDARVFFTTSGTEANDTALLLATAYRRSNAILAMRNSYHGRSFSTVGITGNRGWSPTSLSPLQTLYVHGGVRTRGPYADLDDRDFIDACVTDLKDLLGHSRAPAALIAEPVQGVGGFTSPPDGLYAAFREVLHERGILWISDEVQTGWGRTGEHFWGWQAHARSGPPDIVTFAKGIGNGMSIGGVVARAEIMNCLDANSISTFGGTQVTMAAGLANLNHLLEHDLQGNARRVGGLLIERLRAVAAQVPHVREVRGRGLMIGVELTRPGTDEAAPEAASTVLEEARAGGLLVGKGGGHSTSVLRIAPPMSLTVAEAEEGAAILERALRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJN5</accession>
    <name>Q8CJN5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6299</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAD55507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733696.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030806.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6299"/>
    <dbReference type="GeneID" id="1101740"/>
    <dbReference type="KEGG" id="sco:SCO6299"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6413"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_3_11"/>
    <dbReference type="InParanoid" id="Q8CJN5"/>
    <dbReference type="OMA" id="MEATFRA"/>
    <dbReference type="PhylomeDB" id="Q8CJN5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="30674" checksum="7F9290DA74AB8767" modified="2003-03-01" version="1">METDDVPGGAPNADTAARVREVIAAAGVSQREFARRVVMDPSKLSRSLSGTRRFTVAELARIADEGRIDAGRLLGTRSREKATPPAAHVEGGRPLQIVRETVRLIAEHGFHAVRVADIARACATSSAAIHYHFPGRAELLEAAVRWCMDEDTARRAARLAEADDAAAELSQLIALQTPRTAQQRRQWAVWLDLWAEAARSTTVGRLHSEYYRQWRETVADVVRRGVGQGVFRAGLDPQAAALTLTALIDGLATHVLSVDGTASAGAADAMHAALTTHVNDTILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJS9</accession>
    <name>Q8CJS9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4790</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO4790"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4865"/>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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        <property type="entry name" value="DUF2154"/>
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        <property type="entry name" value="Phageshock_PspC_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="106"/>
        </location>
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    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="318"/>
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    </feature>
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        <location>
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    </feature>
    <feature type="domain" description="PspC" evidence="8">
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            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="9">
        <location>
            <begin position="367"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD55215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="473" mass="49123" checksum="5C32AC63265A1283" modified="2003-03-01" version="1">MTDHEHAATGPGPGSGPRPPQGAGPQDAAPAADAGAAGPGAAGGTDAAGPTHRFRRDRRHKSLAGVCAGLGRQCDMDPVIFRITLAVLSATGGIGLIFYGFAWLFVPYEDEEENEVRKLLTGRVDGHALAAVLFALVGCGVFLTMLRNGGVLTFAVVLSLLLAGAGYWSRHRRAPEPDPLSAQAVADAPPEAKAPPIMYTWPSWWRDPIVKDGTHDGGTGYMWGPPDSAERDIAAAVNIGRGIPGRRDRATAGDRHSWSAQTRGPRGIGGWVFLLALLAGFLGARLTWDDHPLGTSLQTGLACALAVFGLGIAVSSFLGRTGAGSIFLAVITAGLLAGSAAVPENVGTDWVRTTWKPVVAADVRDQYDLGTGSGTLDLSRLDLAEGQTVTTRADVGMGRIRVVVPPDVTVRLYVEVGVGDIQLPGDNKKDVDVAPGKHKEITLPPAEGGKSSGTLDLDLQVGVGQAEVSRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJY2</accession>
    <name>Q8CJY2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2937</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAD55458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T36160"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1098370"/>
    <dbReference type="KEGG" id="sco:SCO2937"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2995"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_2_6_11"/>
    <dbReference type="InParanoid" id="Q8CJY2"/>
    <dbReference type="OMA" id="TSLFGMV"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="248"/>
        </location>
    </feature>
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            <end position="274"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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        <location>
            <begin position="351"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="483" mass="49174" checksum="A86E0471F302F6F0" modified="2003-03-01" version="1">MTVPEPRDTDVAAPVEPALAPAAPAETVLSRAYRALSIGIVSVIVLIAFEATAVGTAMPVAARELDGVSLYAFAFSGYFTTSLFGMVLSGQWSDRRGPLAPLTTGIATFAAGLVLSGTAGAMWLFILGRAVQGFGGGLVIVALYVVVGRAYPERLRPAIMAAFAAGWVVPSVVGPLASGAVTEHLGWRWVFVGIPVLVVVPLALALPQIRSRASGPVGGGDTPASFDGRRIRLALAISLGAGLLQYAAQDLRWVSLLPGAAGVALLVPAVLGLLPRGTYRAVRGLPSVVLLRGVAAGSFIAAESFVPLMLVTQRGLSPTLAGLSLAAGGATWAGGSWLQSRPRLEPHRERLMALGMLLVAAAITTAPSVLIEAVPAWTVAVAWAFGCFGMGLVISSTSVLLLKLSAPEEAGTNSAALQISDGLSNVVLLSAGGAAFAALGGGTVSHTATEATGSHPAAFAVVFLPMAAVALAGAWVATRIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK01</accession>
    <name>Q8CK01_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-06" db="PDB data bank">
            <title>Structure of putative secreted protein DUF305 from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Ramagopal U.A."/>
                <person name="Rutter M."/>
                <person name="Adams J."/>
                <person name="Toro R."/>
                <person name="Groshong C."/>
                <person name="Sauder J.M."/>
                <person name="Burley S.K."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 38-205</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733565.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028217.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="PDB" id="2QF9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.69 A"/>
        <property type="chains" value="A/B=38-205"/>
    </dbReference>
    <dbReference type="PDBsum" id="2QF9"/>
    <dbReference type="SMR" id="Q8CK01"/>
    <dbReference type="STRING" id="100226.SCO2239"/>
    <dbReference type="DNASU" id="1097672"/>
    <dbReference type="GeneID" id="1097672"/>
    <dbReference type="KEGG" id="sco:SCO2239"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2277"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK01"/>
    <dbReference type="OMA" id="MTWMGMG"/>
    <dbReference type="PhylomeDB" id="Q8CK01"/>
    <dbReference type="EvolutionaryTrace" id="Q8CK01"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF305" evidence="1">
        <location>
            <begin position="43"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2QF9"/>
        </source>
    </evidence>
    <sequence length="208" mass="22339" checksum="74585693DA8EEBAA" modified="2003-03-01" version="1">MTAKRAGWIAGAAAAVLLAAGGITYAVAGDDGGSRIPAADSADAGFARDMSVHHQQAVEMSYIVRDRTDDEEVRRLAYDIAQTQANQRGMMIGWLDLWALPKVSSDPPMTWMGMGDAPSAGEGSLMPGMATDAEMKKLGTLDGKQAEVYYLQLMTEHHRGGVHMAKGCVERCTVGVEKRLARGMVESQESEIRLMADLLAERGAKPRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-26" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK04</accession>
    <name>LIPB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Octanoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipB</name>
        <name type="ordered locus">SCO2193</name>
        <name type="ORF">SC5F7.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35309">
        <property type="entry name" value="T35309"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733562.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976622.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8CK04"/>
    <dbReference type="SMR" id="Q8CK04"/>
    <dbReference type="STRING" id="100226.SCO2193"/>
    <dbReference type="PRIDE" id="Q8CK04"/>
    <dbReference type="GeneID" id="1097626"/>
    <dbReference type="KEGG" id="sco:SCO2193"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2230"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_2_1_11"/>
    <dbReference type="InParanoid" id="Q8CK04"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="PhylomeDB" id="Q8CK04"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000062881" description="Octanoyltransferase">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="35"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01067"/>
        </source>
    </evidence>
    <sequence length="265" mass="29618" checksum="7887FD0293ACC728" modified="2003-03-01" version="1">MSELRFVRMGFGADRVEYQEAWDEQRRVHAARFVDEVPDTVLLLEHPPVYTAGRRTEDSERPLDGTPVIDVDRGGKITWHGPGQLVGYPIQKLPRPVDVVAHVRRLEEALIRTCAEFGLETSRVEGRSGVWVLGDPVEQRPVLGGLSLDFDPRLSDDEFDPRLNGPEYAPSNAGQRREDRKIAAIGIRVAKGVTMHGFALNVNPDNKWFDKIIPCGIRDAGVASLANELGRDVTIEEVLPVAERHLRDVLENAELKPRVIEKTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK22</accession>
    <name>Q8CK22_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gluconate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1680</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAD55286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36781">
        <property type="entry name" value="T36781"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733541.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977145.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1680"/>
    <dbReference type="GeneID" id="1097111"/>
    <dbReference type="KEGG" id="sco:SCO1680"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1697"/>
    <dbReference type="eggNOG" id="COG2610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027949_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK22"/>
    <dbReference type="OMA" id="LMRIGIP"/>
    <dbReference type="PhylomeDB" id="Q8CK22"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035429">
        <property type="term" value="P:gluconate transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="465" mass="47968" checksum="9FF6BE85C11CAD1B" modified="2003-03-01" version="1">MTRLSVEMLAADPVEPITSAGHAQLGIAVLLGIAVIVLLITKFKLHAFLSLTIGSLALGAFAGAPLDKVITSFTAGLGSTVAGVGVLIALGAILGKMLADSGGADQIVDTILAKATPRSMPWTMVLIASVIGLPLFFEVGIVLLIPVVLMVAKRGNYSLMRIGIPALAGLSVMHGLVPPHPGPLVAIDAVDANLGVTLALGVLIAIPTVIIAGPVFSKYAARWVDVPAPDRMIPQRASERLDKRPSFGATLATILLPVVLMLLKALVDIIIDDPDNVVQRTFDVIGNPLIALLVSVIVGIFTLLRPAGFGKDRLSGLVEKGLAPIAGILLIVGAGGGFKQTLIDSGVGQMVLDISKDWSIPALLLAWLIAVVIRLATGSATVATVSAAGLVAPLAADMSTTHAALLVLAIGAGSLFFSHVNDAGFWLVKEYFGLNVGQTIKTWSVMETIISVVAGALVLLLSLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IY4</accession>
    <name>Q93IY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5101</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629251.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973877.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5101"/>
    <dbReference type="GeneID" id="1100542"/>
    <dbReference type="KEGG" id="sco:SCO5101"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5182"/>
    <dbReference type="eggNOG" id="ENOG5033HDE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202640_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IY4"/>
    <dbReference type="OMA" id="PWLVIRQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="7037" checksum="BBA462D68C1CA5C3" modified="2001-12-01" version="1">MNDSTVTLPWLVFRQDDNGNRYRVGRYATRAEAQEIADTLDGRGHKQLYWVEKLAAPGAGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J67</accession>
    <name>Q93J67_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625272.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027485.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0976"/>
    <dbReference type="GeneID" id="1096399"/>
    <dbReference type="KEGG" id="sco:SCO0976"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.973"/>
    <dbReference type="eggNOG" id="COG4126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_733445_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="377" mass="37526" checksum="B7E2CE426B908DBC" modified="2001-12-01" version="1">MLALLHTSAVHVAVFDALRDAGHPGLELRHHVDAGLLERARCEGPEAVADAVAAVLRRAVAEGARAVLCTCSTIGGVAEAAAAGAGVPVLRVDRPMAAAAVAAGPRVLVLAALESTLAPTAALIAEEARRADRPVEVRTLLVEGAWSRFEAGDGEGYLRRVAEAADAVTGADVIVLAQASMAPARKSTTARVPVLASPEPGLAAGAAARGDRPSTLGHPDAGVLPAGEWGGGRRVGGGQVHRADVDRLAGGQRHDEPVSGSRPARAHSRTLSRSGPGAPASAAGPGLTTGPRPGADPSAAAPGSRPATHAPAAGPRPAADPSAPRPGPAAAARSSRARAVPDPTGARARAQPRARAAPHLSEGRRTPGKGAGNGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF8</accession>
    <name>Q93JF8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030572.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5969"/>
    <dbReference type="GeneID" id="1101411"/>
    <dbReference type="KEGG" id="sco:SCO5969"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6067"/>
    <dbReference type="eggNOG" id="COG1694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110454_1_0_11"/>
    <dbReference type="InParanoid" id="Q93JF8"/>
    <dbReference type="OMA" id="KMDTNRQ"/>
    <dbReference type="PhylomeDB" id="Q93JF8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="13167" checksum="CAA04081E8F59613" modified="2001-12-01" version="1">MTDHPRDLAALRRRLAEFAAARDWQPYHTPKNLAAALSVEASELLEIFQWLTPEQSARVMTDPDTAHRVRDEVADVLAYLLQFCEVLGVDPLAALEEKIERNESRFPVAGEVGRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QB5</accession>
    <name>Q99QB5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.31</name>
        <name evidence="4" type="ordered locus">SCP1.323c</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639607.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639931.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039333.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095110"/>
    <dbReference type="GeneID" id="1095405"/>
    <dbReference type="KEGG" id="sco:SCP1.31"/>
    <dbReference type="KEGG" id="sco:SCP1.323c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7977"/>
    <dbReference type="HOGENOM" id="CLU_043034_3_0_11"/>
    <dbReference type="OMA" id="PCENTIV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010147723" evidence="1">
        <location>
            <begin position="28"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="219" mass="23719" checksum="7FC65B09168A733B" modified="2001-06-01" version="1">MVTSVLRGLVAALLAVLSITASTPAQAAQTLTVAEAVTRLPVDAESRVGYDRDAFRHWNRGDDPSDGCSTRNEVLIAEAVEPPTVGPRCRLTGGRWWSYYDQVWVASASGLDIDHMVPLAESWDSGAFAWTAKRREAYANDQGAQTSLVAVTARSNRSKADQDPAQWMPPAAAAHCRYIAEWVGTKLRWSLTADETEVAALRDAASDCPGQRVTFELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACW4</accession>
    <name>Q9ACW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639774.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039486.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095266"/>
    <dbReference type="KEGG" id="sco:SCP1.187"/>
    <dbReference type="HOGENOM" id="CLU_1474338_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="19379" checksum="ECFF3DCA12EDA4C9" modified="2001-06-01" version="1">MGRLRTPDFAASKAAKLLDSVSLILTERQSHLLAGSGPHENCGELASTNSSQRRGAHQDRGIIFTTSNGGETVAKKPNPKIARALRPRMGIPEHATEEDLLAYLRASMALSTDQPHELSRVMASLRGSSEHSNLSLQTMAIAAMTASHVAHMEEVRLPASPEDEETSPPGDVDGGVPAPSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADI3</accession>
    <name>Q9ADI3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630188.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030638.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6080"/>
    <dbReference type="GeneID" id="1101521"/>
    <dbReference type="KEGG" id="sco:SCO6080"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6182"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047694_2_0_11"/>
    <dbReference type="OMA" id="EQPEWLP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="385" mass="42134" checksum="D7FA09CD13D02E29" modified="2001-06-01" version="1">MGGATALRLAERAVADPRLTEGADATWNLLLCVDPDGLRRNEGWLTGPYTLGRYARNFFRPGFLEQPEWLPDGPDRATLPETRTLLALQDELRPFLQCSLHGVDVGGGFVELTHELPGLAQRISHTAARLGIPRELGAYDTLYWPDLGPAVYRIPPPRRGDLTAAITEAAVDSTWCHPRRHGTVTAVVEAPMWGVAAVADDSPPVDRDGVLRTVSRTLRHDTRRLRRVLARLRPHLAAVPEAAHLLAPVDDYLLVCPRLADEWDPDTDDRTDRSLPPMNTSHLVALRLAGRRLSLRTAGLLHQLVTRTGGDPAGVLAELDRLVDEGCADYRDGCGAHWIPVGRQVEYQTRVVLAAFELAGRRAAAGARSGEPGRGSEAAVPMHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN6</accession>
    <name>Q9ADN6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO4021</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628203.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029388.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4021"/>
    <dbReference type="GeneID" id="1099457"/>
    <dbReference type="KEGG" id="sco:SCO4021"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4084"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="InParanoid" id="Q9ADN6"/>
    <dbReference type="OMA" id="AMNRVES"/>
    <dbReference type="PhylomeDB" id="Q9ADN6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176615" description="Histidine kinase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="279"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC32361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="524" mass="55483" checksum="713C407E7C5043A8" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF5</accession>
    <name>Q9EWF5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate reductase delta chain NarJ3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4949</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629101.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029970.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4949"/>
    <dbReference type="GeneID" id="1100390"/>
    <dbReference type="KEGG" id="sco:SCO4949"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5029"/>
    <dbReference type="eggNOG" id="COG2180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084469_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EWF5"/>
    <dbReference type="OMA" id="HYSFVVG"/>
    <dbReference type="PhylomeDB" id="Q9EWF5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016530">
        <property type="term" value="F:metallochaperone activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="24404" checksum="7FE62B798742C48D" modified="2001-03-01" version="1">MSRSLGRAATTTNAPVVFQAAALLLAYPDRDWPRRPHTVRDTVAALPGPEIQLLLSFCDRAEREDPLAVAARYVATFDRSRRRCLYLTYYTDGDTRRRGAALARIKSVYRTHGWLPPDDELPDFLPLMLEFAARTPEAGTALLTEHRAAIEVLRYALEAHRSPYAALLQAVGRCLPGRAPASREEALRLTRTGPPTEAVGLDVLGPFPAQPRPHDDGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWJ2</accession>
    <name>Q9EWJ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031766.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7592"/>
    <dbReference type="GeneID" id="1103030"/>
    <dbReference type="KEGG" id="sco:SCO7592"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7708"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_11"/>
    <dbReference type="InParanoid" id="Q9EWJ2"/>
    <dbReference type="OMA" id="DAVFWLV"/>
    <dbReference type="PhylomeDB" id="Q9EWJ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="31513" checksum="BC249C508043B33C" modified="2001-03-01" version="1">MIVITAPTGNIGRRLLPLLLESAPARGEELRVIVRDPARLAAPVRERVEVVTGSHGDPAVVDRAFDGADAVFWLVPPDSSRTPDDAYRGFTRPAAHALVAHGVGHVVGVSALGRGTPVAARAGLVTASLAVDDLIAETGVAHRALASPSFFENLLEEADSIREHGCFTDVLDADRKSPLVAVADIASVAAGLLLDRSWTGTGSVPVLGPRDLSPNDLARIMTERLGRPVRYERHTLDDLRSTLVGYGLDKDFVDGVVDMKRAKDDGLDAGVTRTPDTATPTTFEDWVARTLGPVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWL1</accession>
    <name>Q9EWL1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631811.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031905.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1103216"/>
    <dbReference type="KEGG" id="sco:SCO7779"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7896"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_17_2_11"/>
    <dbReference type="InParanoid" id="Q9EWL1"/>
    <dbReference type="OMA" id="QIITREY"/>
    <dbReference type="PhylomeDB" id="Q9EWL1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="25473" checksum="A9FDCD5EEE2E316F" modified="2001-03-01" version="1">MAKLSTLAIVGAGPQLGRAIGRRFAVEGVDVALIARSRTTLQAVADELSDTGVRAEVFPADVTDRPALHAALTAAEERLGPIDILEYSPAPSPADLRRAPLVEATKVTVDSVLAQLDLYLLGGVAAVQHVLPGMLERGTGTILVSSGAGSGPVIAPHVANVQIATGGMRNWILNLHAALSGTGVYAAHVAIAAYIGQGGHDSQPQTIADAYWRLHTGRTEAELVIQDLPDDYLDRGLADKFVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWM1</accession>
    <name>Q9EWM1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7768</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631801.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031895.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7768"/>
    <dbReference type="GeneID" id="1103205"/>
    <dbReference type="KEGG" id="sco:SCO7768"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7885"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124277_1_2_11"/>
    <dbReference type="InParanoid" id="Q9EWM1"/>
    <dbReference type="OMA" id="MEFPFAP"/>
    <dbReference type="PhylomeDB" id="Q9EWM1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="16238" checksum="F0AB11B5F3501572" modified="2001-03-01" version="1">MHSTPEETFRRMIDLLLAKDMNAVADLWAPDGIAEFPFAAGRSPRVLRGREEVRAYLAHYPELMDMKEVAALTVRPTNRTDTVVVEWTATGRTVATSQPYLLDYIVVLTVRDGRIALFRDYWSPLSAAAAAGTLAGLIDSLERKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Y3</accession>
    <name>Q9F2Y3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628534.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974617.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4364"/>
    <dbReference type="GeneID" id="1099804"/>
    <dbReference type="KEGG" id="sco:SCO4364"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4432"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136060_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F2Y3"/>
    <dbReference type="OMA" id="DDAICDY"/>
    <dbReference type="PhylomeDB" id="Q9F2Y3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="125" mass="14127" checksum="20DDF2FDB310D441" modified="2001-03-01" version="1">MESSKVIETLWDRIQARDWAAVAGLIAEDAVVEWPISLERIVGRENFVAVNREYPEGWSIRVLKVVAEGDEVVSEVEVPHDSLGVFRAASFWTVRDGQVVRGTEYWTSMGADPRPEWRAALVEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3H2</accession>
    <name>Q9F3H2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2809</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627039.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028599.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2809"/>
    <dbReference type="GeneID" id="1098243"/>
    <dbReference type="KEGG" id="sco:SCO2809"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2867"/>
    <dbReference type="eggNOG" id="ENOG502Z9GY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543818_0_0_11"/>
    <dbReference type="OMA" id="GRSMRFR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC10118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="547" mass="59294" checksum="AA5C64E998587642" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3N1</accession>
    <name>Q9F3N1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7656</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631696.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031807.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7656"/>
    <dbReference type="GeneID" id="1103094"/>
    <dbReference type="KEGG" id="sco:SCO7656"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7776"/>
    <dbReference type="eggNOG" id="ENOG5034AYR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111966_0_0_11"/>
    <dbReference type="OMA" id="AFRAQWP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="17954" checksum="903873D99B178FB1" modified="2001-03-01" version="1">MLALLPDAEPLLRAAAAVDGSAVRPGLPAHATLLYPWLPADEVGEPELRRLRAALPVGPVPVRLATVERTGGFVGVPVPGLDQVADAVRTAFPAQVPYGGRFGPRPQVHVTVALDAAPQAAADIARRTGAVLPIATAVNTLHVVTLARAGWRGLAELPLSRQHGEPQPLAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3P4</accession>
    <name>Q9F3P4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7643</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631683.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031799.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7643"/>
    <dbReference type="GeneID" id="1103081"/>
    <dbReference type="KEGG" id="sco:SCO7643"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7763"/>
    <dbReference type="eggNOG" id="COG4430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157172_1_0_11"/>
    <dbReference type="OMA" id="KGGWTYV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC16976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="91" mass="10067" checksum="9DB933087A3E0309" modified="2001-03-01" version="1">MTMDRQFTATLLKSPNKGGWTYVVWPESVEYFGTRGLVKVRGTIDGHPFQGSFMALGDGTHKLPVRADTRRAIGKEEGDTVTVRLVERLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBP1</accession>
    <name>Q9FBP1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5036</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629188.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973941.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5036"/>
    <dbReference type="GeneID" id="1100477"/>
    <dbReference type="KEGG" id="sco:SCO5036"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5114"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_0_1_11"/>
    <dbReference type="OMA" id="HDRPLHY"/>
    <dbReference type="PhylomeDB" id="Q9FBP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="19827" checksum="F52FE9B46F1C8D88" modified="2001-03-01" version="1">MSIGHTLLGLLESGPRHGYDLKRAFDEKFGHDRPLHYGQVYSTMSRLLKNGLVVVDGIEAGGGPERKRYAITDEGITDVQRWLATPEKPEPYLQSTLYTKVVLALLTHRDAADILDTQRSEHLRSMRILTDRKRKGDLADQLICDHALFHLEADLRWLELTAARLDKLREAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBV8</accession>
    <name>Q9FBV8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7827</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37083">
        <property type="entry name" value="T37083"/>
    </dbReference>
    <dbReference type="PIR" id="T37084">
        <property type="entry name" value="T37084"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631855.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031941.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7827"/>
    <dbReference type="GeneID" id="1103265"/>
    <dbReference type="KEGG" id="sco:SCO7827"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7935"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029608_5_1_11"/>
    <dbReference type="InParanoid" id="Q9FBV8"/>
    <dbReference type="OMA" id="WHLLVNA"/>
    <dbReference type="PhylomeDB" id="Q9FBV8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC03645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="549" mass="61322" checksum="A1B03230FB17AB8E" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC71</accession>
    <name>Q9FC71_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7115</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631176.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031442.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7115"/>
    <dbReference type="GeneID" id="1102553"/>
    <dbReference type="KEGG" id="sco:SCO7115"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7215"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780634_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC71"/>
    <dbReference type="OMA" id="GSPFWLE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="366" mass="39766" checksum="299338598B1E90B3" modified="2001-03-01" version="1">MMYDSPAVLDAGPSDGVDPDEFVRAAVRWHFDPETGSRYWLDRAERLAFDPRRDVKGVDDLALFPDLSDELRQVPVADLIPRGYGGGARLLNVFDSGGTTGAPKRVVQLDDWMRHSTAQVDRRLREHGLPVGAQWLTVAPTGPHLVGDVLQRAAASLGGPGLSIDMDPRWVRKLIATGRGDEVESYTDHLVEQCRRILLTQDIGVLAATTPLLERFAREEDLLERINGSVRAIVWGGTHMDPDTRHLLATEVFPEVPLIGMYGNTMMLTALLERAGLDASQPCVFDPVSPYVFLSVVDPATGEPVAVGERGQVIVSHVSKSMLIPHNAERDTAVRVRPAGGHAGDAVADVAPVPTVKGETVIEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCC7</accession>
    <name>Q9FCC7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NLP/P60 family protein (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1240</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625528.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977591.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096663"/>
    <dbReference type="KEGG" id="sco:SCO1240"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1239"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_8_1_11"/>
    <dbReference type="InParanoid" id="Q9FCC7"/>
    <dbReference type="OMA" id="LTLYSFK"/>
    <dbReference type="PhylomeDB" id="Q9FCC7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176705" evidence="2">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="157" mass="16607" checksum="C08EE82FEDE991EA" modified="2001-03-01" version="1">MSALNRVPSLMARAGTASALTLAAVGGSVVVPGAAAEAAAASHATKALKIAASKKGAPYRWGATGPHRFDCSGLTLYSFKKAGKKLPRTAAQQYNKTSRVSVRHRKAGDLVFFHSGSSVYHVGIYAGKGRIWHAPKTGAVVRLEKIWTSSVWYGRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCF0</accession>
    <name>Q9FCF0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628395.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029511.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4220"/>
    <dbReference type="GeneID" id="1099660"/>
    <dbReference type="KEGG" id="sco:SCO4220"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4283"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCF0"/>
    <dbReference type="OMA" id="KVEIGSW"/>
    <dbReference type="PhylomeDB" id="Q9FCF0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="15344" checksum="6D15FCDEBBF5EA48" modified="2001-03-01" version="1">MTSRFTELVLDCHDPERLAAFWCAVLDFKVIDRGEGKVEIGSWEPTVEEVRTRQMPPTIVFIRVPEGKTVKNRLHLDVSPIDASTEDEAARLLALGATRVDVGQGPGRSWVVMADPEGNEFDVVRSLAPSAQRLPADCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCJ2</accession>
    <name>Q9FCJ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5196</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629344.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973780.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5196"/>
    <dbReference type="GeneID" id="1100637"/>
    <dbReference type="KEGG" id="sco:SCO5196"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5279"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057502_2_1_11"/>
    <dbReference type="InParanoid" id="Q9FCJ2"/>
    <dbReference type="OMA" id="MVAYEGF"/>
    <dbReference type="PhylomeDB" id="Q9FCJ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="24009" checksum="F06C9BCD5DFF3C52" modified="2001-03-01" version="1">MNQPLAGYAPAPAGARMENHGNHMLKVAMQTGNDLLARVGSMTAYEGFVQYEPNPPAVRQIAKDWMTGEGAPLMKCSGDGLLYLADYGANVVVINLNGDGISVNATNLLAFDAHLTWGVERVKGLAKFAGQGLWNTKISGQGWVALTSRGKPIVVDCGGGEDETYVDPDALVAWSPNLKVKGKRSFKAQSLIGRGSGEAFQMAFSGQGIVVVQPSEDSTDRLRVRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J6</accession>
    <name>FOLD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD</name>
        <name type="ordered locus">SCO4824</name>
        <name type="ORF">SC2A6.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628980.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974148.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3J6"/>
    <dbReference type="SMR" id="Q9K3J6"/>
    <dbReference type="STRING" id="100226.SCO4824"/>
    <dbReference type="GeneID" id="1100265"/>
    <dbReference type="KEGG" id="sco:SCO4824"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4900"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_3_0_11"/>
    <dbReference type="InParanoid" id="Q9K3J6"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="PhylomeDB" id="Q9K3J6"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000268527" description="Bifunctional protein FolD">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="284" mass="29790" checksum="8D9547DAC65E27F4" modified="2000-10-01" version="1">MTAQILDGKATAAAIKSELTARVAALKERGVTPGLGTVLVGDDPGSQKYVAGKHRDCAQVGIASIQRELPATATQEEIEAVVRELNEDPACTGYIVQLPLPRGIDENRILELMDPDKDADGLHPMNLGRLVLNEPAPLPCTPNGILTLLRRYGVEIKGAEVVVVGRGVTIGRPMPLLLTRRSENATVTQCHTGTRDLAAHLKRADIVIAAAGSPHLVRPEDVKPGAAVLDVGVSRNAEGKIMGDVHPGVAEVAAWISPNPGGVGPMTRAQLLVNVVEAAERSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3N2</accession>
    <name>Q9K3N2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1028</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977801.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1028"/>
    <dbReference type="GeneID" id="1096451"/>
    <dbReference type="KEGG" id="sco:SCO1028"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1023"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046285_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3N2"/>
    <dbReference type="OMA" id="ARYVHYM"/>
    <dbReference type="PhylomeDB" id="Q9K3N2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="49"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB96013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="374" mass="41352" checksum="FB6A4E44A7224E32" modified="2000-10-01" version="1">MSTDRQTGTGTTLDVDRSDASYRAWLKEAVRKVQADANRSADTHLLLFPLPEHWGIDLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIRPDRPVIEASSGSTAVSEAYFAKLVGVPFIAVMPRTTSAEKIRLIEFHGGRCHFVDDSRRMYEESARLAAETGGHYMDQFTYAERATDWRGNNNIAESIFRQLRLERYPEPSWIVATAGTGGTSATLARYVHYMQYDTRVCVADPDNSCFFEGWTTGDPDVACDRGSRIEGIGRPRMEPSFVPGAIDRMMKVPDAASVAAVRSLERAIGRRAGGSTGTGLWSALKIVAEMVAAGERGSVVTLLCDPGDRYLDKYYSDAWLAEQGLDIEPYTAAIESLLRTGSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K437</accession>
    <name>Q9K437_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1062</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625356.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027553.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1062"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1096485"/>
    <dbReference type="KEGG" id="sco:SCO1062"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1059"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_2_1_11"/>
    <dbReference type="InParanoid" id="Q9K437"/>
    <dbReference type="OMA" id="PINDNCG"/>
    <dbReference type="PhylomeDB" id="Q9K437"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="22"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="219"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="277"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="693" mass="75941" checksum="E54676BCCA33A921" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K472</accession>
    <name>Q9K472_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7213</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631269.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031514.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7213"/>
    <dbReference type="GeneID" id="1102651"/>
    <dbReference type="KEGG" id="sco:SCO7213"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7312"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037315_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K472"/>
    <dbReference type="OMA" id="IPRIFNI"/>
    <dbReference type="PhylomeDB" id="Q9K472"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017031">
        <property type="entry name" value="Pre_MeTrfase_YjhP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034653">
        <property type="entry name" value="Mtase_yjhp_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="27350" checksum="E64D8954B3EA7109" modified="2000-10-01" version="1">MDLPRIFTIRESGHRIHNPLTPDKFATLGASLRLPAGTRVLDLASGSGEMLCTWARDLGFTGTGVDIGSLFTEQARARAAELGVADRVDFIHGDAAGHVADRPVDLAACVGATWIGDGVAGTIELLERSLRPGGLILIGEPFWRQTPPDEETAQGCHATSTADFLVLHGLIEHFQDLGYDVVEMMLADQDSWDRYAAAQWLSMRRWLDENPDDEMAPQVREELGLEPARYARYGREYLGWGVFALMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4K1</accession>
    <name>Q9K4K1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7313</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631368.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031581.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7313"/>
    <dbReference type="GeneID" id="1102751"/>
    <dbReference type="KEGG" id="sco:SCO7313"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7416"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_22_1_11"/>
    <dbReference type="OMA" id="WPIVCRL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="15697" checksum="54BA46309DA89B31" modified="2000-10-01" version="1">MRDRDTIQPVVEQRGGDTGRRYRPCRPADARAAVERAVTECRGAGGRASCDPCALSDAVLVASELTTNAILHGGGITDFQVDVVGPGVRLSVCDRSHDLPVAVPATDDRGRRRLGGRGWPIVCRLAREVRVADLPSGGKCITVVVPLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXP2</accession>
    <name>SYH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">SCO1508</name>
        <name type="ORF">SC9C5.32c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625788.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977318.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXP2"/>
    <dbReference type="SMR" id="Q9KXP2"/>
    <dbReference type="STRING" id="100226.SCO1508"/>
    <dbReference type="PRIDE" id="Q9KXP2"/>
    <dbReference type="GeneID" id="1096934"/>
    <dbReference type="KEGG" id="sco:SCO1508"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1517"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KXP2"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="PhylomeDB" id="Q9KXP2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136274" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="425" mass="46508" checksum="C91C7E79DE5E5B63" modified="2000-10-01" version="1">MTRPSVSTFKAPKGTYDLLPPDSAKFLAVREAIAAPLRNSGYGYIETPGFENVELFARGVGESTDIVTKEMYVFETKGGDRLALRPETTAPVLRAVLEANLHKAGNLPVKVWYSGSQYRYERPQKGRYRHFSQVGAEAIGAEDPALDAELIILADQSYRALGLQDFRILLNSLGDQECRPVYRAALQDFLRGLDLDEETLRRAEINPLRVLDDKRPDVQKQLTEAPLLRDYLCDACKAYHEEVRELITAAGVVFEDDPKLVRGLDYYTRTTFEFVHDGLGSQSAVGGGGRYDGLSEMIGGPSLPSVGWALGVDRTVLALEAEGIELDIPSATSVFAVPLGEEARRILFAKVTELRKNGVAADFSYGGKGLKAAMKAANRSGARYTLVLGERDLAEGVVQLKDMESGEQTAIGVNEIVAELESRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXQ1</accession>
    <name>Q9KXQ1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ordered locus">SCO1499</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625779.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977327.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1499"/>
    <dbReference type="GeneID" id="1096925"/>
    <dbReference type="KEGG" id="sco:SCO1499"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1508"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_4_3_11"/>
    <dbReference type="InParanoid" id="Q9KXQ1"/>
    <dbReference type="OMA" id="TDWDPGP"/>
    <dbReference type="PhylomeDB" id="Q9KXQ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB93379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="582" mass="63706" checksum="C1303771BF070F5F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXY3</accession>
    <name>Q9KXY3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3865</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029279.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3865"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1099301"/>
    <dbReference type="KEGG" id="sco:SCO3865"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3936"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085736_0_0_11"/>
    <dbReference type="OMA" id="LLYRKWP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28358" checksum="286837E6A721E9F9" modified="2000-10-01" version="1">MNRRVVIVTAVHGPSAPFLPEAYASLCAQELPDGWEWRWVIQEDGRTQDVRPHVPDDPRVVFHQGRHGRQGGPGVARTMALAHADGAYVKVLDADDRLTPGALARDLAALEADPSIGWATSRVLDLLPDGSTAGFPGDPAHGPIERGEVLDFWRANGFRAQVHPATLLVRRDLLLAVGGWMALPASEDTGLLLALNCVSRGWFTEDVGLLYRKWEGQETGQASHVDPAERDARMTVVEARARALASFGWRLPEGTGDFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYD8</accession>
    <name>Q9KYD8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4132</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628310.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029455.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4132"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="GeneID" id="1099572"/>
    <dbReference type="KEGG" id="sco:SCO4132"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4194"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054383_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KYD8"/>
    <dbReference type="OMA" id="RFDPIDT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="204"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="35682" checksum="516F68207D31962A" modified="2000-10-01" version="1">MGDGWTMRKMWVGAGVAVALGMGFVMLLVVGVYLVAGNLAGGGAGGGAKKLAKGSVPAVYQPIVQKWGNLCPAINPALLAAQLYQESGFDPKARSAATAQGIAQFIPGTWAVHGVDGDGDGDRDVWDPEDAIPSAASYDCSLASYVKSVPGNPTENMLASYNAGPDAVIRYQGVPPYEETRNYVKTITTLEKSFAAPTTRVDPSEQAAGAIAYAQKKLGTLYLWGGNGTPEQGGRFDCSGLTKAAYESVGIKLPRVANDQYNAGPHPGRDELLPGDLVFFSDDLTNSRAIRHVGIYVGGGYMIDAPRTGAVIRFDPIETPDYFGATRVTEDGAKALPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH9</accession>
    <name>Q9KYH9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxygenase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2693</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the clavaminate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626927.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028519.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2693"/>
    <dbReference type="GeneID" id="1098127"/>
    <dbReference type="KEGG" id="sco:SCO2693"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2749"/>
    <dbReference type="eggNOG" id="COG2175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044078_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYH9"/>
    <dbReference type="OMA" id="CLRADHE"/>
    <dbReference type="PhylomeDB" id="Q9KYH9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014503">
        <property type="entry name" value="Clavaminate_syn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019543">
        <property type="entry name" value="Clavaminate_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="7">
        <location>
            <begin position="119"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR019543-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019543-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB92259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="333" mass="35272" checksum="5F68A7704EC2480E" modified="2000-10-01" version="1">MTSPSPSLSLPVGTPASLALFEAETAAVRRAAERVCRAAGGGLDDPETTAAAREGWEELPVRLRAAVRAFRRNSGECGVTLVTGLPVDEALLPPTPTADGSVRREATVPAATLLMTAAGGLGDPAAYAPEKSGALVQDVVPVPGKEDFEGNAGSTLLSFHVENAFHVHRPDFVMLLCLRADHDGAAGLRTGSIRQALPVLSERTREALFRPEFSTQPPPSFGTAAGTTPPRPVLTGDPEDPDLRVDFSATTAVTPEARRALVELEAAVDAASHTVRLTPGDLAIVDNRVTTHGRTAFRPRYDGGDRWLLRTFAVADLRRSRDHRPGDGHVLSH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI9</accession>
    <name>SSB1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-stranded DNA-binding protein 1</fullName>
            <shortName evidence="1">SSB 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ssb1</name>
        <name type="ordered locus">SCO2683</name>
        <name type="ORF">SCC61A.04c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626917.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976116.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="PDB" id="4DAM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L=1-116"/>
    </dbReference>
    <dbReference type="PDBsum" id="4DAM"/>
    <dbReference type="AlphaFoldDB" id="Q9KYI9"/>
    <dbReference type="SMR" id="Q9KYI9"/>
    <dbReference type="STRING" id="100226.SCO2683"/>
    <dbReference type="GeneID" id="1098117"/>
    <dbReference type="KEGG" id="sco:SCO2683"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2739"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_1_3_11"/>
    <dbReference type="InParanoid" id="Q9KYI9"/>
    <dbReference type="OMA" id="RPEPNWE"/>
    <dbReference type="PhylomeDB" id="Q9KYI9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051096">
        <property type="term" value="P:positive regulation of helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000096115" description="Single-stranded DNA-binding protein 1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SSB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="5"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="17"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="4DAM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16833" checksum="3B5710BFD4D7C692" modified="2000-10-01" version="1">MNETMICAVGNVATTPVFRDLANGPSVRFRLAVTARYWDREKNAWTDGHTNFFTVWANRQLATNASGSLAVGDPVVVQGRLKVRTDVREGQSRTSADIDAVAIGHDLARGTAAFRRTARTEASTSPPRPEPNWEVPAGGTPGEPVPEQRPDPVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYP9</accession>
    <name>Q9KYP9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4483</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB92104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628648.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4483"/>
    <dbReference type="GeneID" id="1099923"/>
    <dbReference type="KEGG" id="sco:SCO4483"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4553"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYP9"/>
    <dbReference type="OMA" id="PPHWHEM"/>
    <dbReference type="PhylomeDB" id="Q9KYP9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="82"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="21657" checksum="8A50F27C8A8E0908" modified="2000-10-01" version="1">MRNGSWTLPMPRRWNRGMSDEPRNSKNAEHGEHAEHAEAGADPAVSVVGPGDGETILLGTTRMRVLEDGSHTGHRLGMAESVLAPHTPGPPQHRHARHDEGFYVISGTVRFTVGDEDIDATAGTLVMVPPGAPHTFANTTGEPARMLSTFTPDLYVQYFRDLEELYAGGRTPTPEESRKTMSRYATEPATGSAGPRGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYW4</accession>
    <name>Q9KYW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3017</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627239.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028718.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3017"/>
    <dbReference type="GeneID" id="1098450"/>
    <dbReference type="KEGG" id="sco:SCO3017"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3077"/>
    <dbReference type="eggNOG" id="ENOG502ZY4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037015_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYW4"/>
    <dbReference type="OMA" id="HLVWYLP"/>
    <dbReference type="PhylomeDB" id="Q9KYW4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025646">
        <property type="entry name" value="DUF4350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14258">
        <property type="entry name" value="DUF4350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329191" evidence="1">
        <location>
            <begin position="30"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4350" evidence="2">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="387" mass="40633" checksum="F6DE33AE67652A57" modified="2000-10-01" version="1">MWTRARGIALALVLLLVGAVAIAVVRSDARHGELDPRSADPYGSRAVAELLADRGVSTRVVTALDEARAAAGPDTTLLVAVPDLLSERQQTGLHSATSGSGGRTVLIAPGGAAVERLAPGVTADPALSVDSTLAPACDLPAARRAGNADTGGIRYSTHLEADACYPSRRLATLLRIPDPSTKASAEAAPGDTVVLGARDILFNNHLDEHGNASLALQLLGSRDHLVWYLPSLSDLPDPDDERGFFDLLPSGWLWGTLQLLIAAVLAALWRARRLGPLVPEKLPVAIRASETVEGRARLYRKANARERAATALRSATRTRLAPLVGVPVAQADSPESLLPALSAHLHGAHGDGQTLHTLLFGPPPGDDAALIALADQLDALEREVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ98</accession>
    <name>Q9KZ98_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4848</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629003.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974124.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4848"/>
    <dbReference type="GeneID" id="1100289"/>
    <dbReference type="KEGG" id="sco:SCO4848"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4926"/>
    <dbReference type="eggNOG" id="ENOG5033055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168335_0_0_11"/>
    <dbReference type="OMA" id="SWVIWIT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8852" checksum="DF49EA899285BD54" modified="2000-10-01" version="1">MKLSRPVSWFLLAFGVWSWIIWITFVKNLVKDGSGLAFEDGDPTAYFWVHLLLAIVSFVLGTVVGVIGLRGVRALRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZF0</accession>
    <name>Q9KZF0_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7003</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631068.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972141.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7003"/>
    <dbReference type="GeneID" id="1102441"/>
    <dbReference type="KEGG" id="sco:SCO7003"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7105"/>
    <dbReference type="eggNOG" id="ENOG5032YW5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064093_2_0_11"/>
    <dbReference type="OMA" id="PVPWVCL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="37580" checksum="080CD2B204D38D43" modified="2000-10-01" version="1">MARDGAQPAYDPAGHDTALRSALQEVRAGRWMSMRILLEQTGTWSQWTRRTQVLAASAAGTDVVRAWLAEEPHSVAGAVMHARVVVERALRAHREAHPRTRELWLQAWHACDAATRAAPHDPVPWVCLLALARLDEGPRWEEHRMAPPEPMLPPGPWGLLAEAGKRDPYNREAHHRMLQFFHPRGGSDRLARAAGFAHWAAGSAPPGSALHVLPLYVRVERYRRSGAREAALDLHWVAEDATREARQAFDSWFTLSPLDERSLPDLNHLAHALWGALRFREANQVFDALGPYWTPLPWACRAPGDGSAGRAVEVFLQARTRSRSAARGRGHGRRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0N2</accession>
    <name>Q9L0N2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4259</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628433.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029537.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4259"/>
    <dbReference type="GeneID" id="1099699"/>
    <dbReference type="KEGG" id="sco:SCO4259"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4326"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016564_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0N2"/>
    <dbReference type="OMA" id="RYANMES"/>
    <dbReference type="PhylomeDB" id="Q9L0N2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="477"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB77353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="690" mass="73488" checksum="DF1458B061A95F5A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0P0</accession>
    <name>Q9L0P0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628425.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974724.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4251"/>
    <dbReference type="GeneID" id="1099691"/>
    <dbReference type="KEGG" id="sco:SCO4251"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4317"/>
    <dbReference type="eggNOG" id="ENOG5031S84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122416_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0P0"/>
    <dbReference type="OMA" id="VENMFAS"/>
    <dbReference type="PhylomeDB" id="Q9L0P0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="18848" checksum="ABF5C16EA7EB4AEE" modified="2000-10-01" version="1">MRRSTAKAPAAAPQTAAAGADFPRSAPAAAPTEAPAGSPAGPPAGPPVDTAPRQQMQTEFPFELPRGYVDESGTVHRDGVMRLSTARDELIPLRDVRVQENPAYLSVVLLGRVITRLGTLAMVHDGVVENMFASDLAFLQDFYRQINAEGHTRAAVECPHCSEPFEVELGGSRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0P7</accession>
    <name>Q9L0P7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Baseplate_J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628418.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974731.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4244"/>
    <dbReference type="GeneID" id="1099684"/>
    <dbReference type="KEGG" id="sco:SCO4244"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4307"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024495_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0P7"/>
    <dbReference type="OMA" id="QPPLVWE"/>
    <dbReference type="PhylomeDB" id="Q9L0P7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="398"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="652" mass="70806" checksum="C572EEA315B61A86" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0W7</accession>
    <name>Q9L0W7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3737</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627928.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029197.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3737"/>
    <dbReference type="GeneID" id="1099173"/>
    <dbReference type="KEGG" id="sco:SCO3737"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3798"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_5_2_11"/>
    <dbReference type="InParanoid" id="Q9L0W7"/>
    <dbReference type="OMA" id="ITCGGPR"/>
    <dbReference type="PhylomeDB" id="Q9L0W7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="208" mass="21498" checksum="E52A0D19B62C05D3" modified="2000-10-01" version="1">MIPRPGRVLATAALAALLVGCGGGQGDGGTAPDRPPPTTAAAPPARTPAEPVRPLARSVPVGLRIPAIGVDTPVMGLGLAADGTVEVPPVTDDDRAGWYRHSPTPGQVGPSVLLGHVTVGRYGDGVFRHLAGLRRGERIEARLENGTTAEFTVTAVRTVAKADFPTDDVYGDVAGPELRLITCGGPRDGQEYRDNVIVFAELSATKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L101</accession>
    <name>Q9L101_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative asnC-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1458</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625739.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977367.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1458"/>
    <dbReference type="GeneID" id="1096884"/>
    <dbReference type="KEGG" id="sco:SCO1458"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1467"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="InParanoid" id="Q9L101"/>
    <dbReference type="OMA" id="FVEIYCR"/>
    <dbReference type="PhylomeDB" id="Q9L101"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB76880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="150" mass="16548" checksum="B3BF66968FBE4730" modified="2000-10-01" version="1">MLNDLDERIVHALAEDARRSYADIGQSVGLSAPAVKRRVDRLRATGAITGFTVRVDPAALGWETEGFVEIFCRRNTSPETIQRGLERYQEVVAASTVTGDADAVAQVFASDMRHFERVLERIAGEPFVERTKSVLVLSPLLRRFSSGSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L187</accession>
    <name>Q9L187_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631440.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031630.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7388"/>
    <dbReference type="DNASU" id="1102826"/>
    <dbReference type="GeneID" id="1102826"/>
    <dbReference type="KEGG" id="sco:SCO7388"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7497"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019327_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L187"/>
    <dbReference type="OMA" id="WSYTHLP"/>
    <dbReference type="PhylomeDB" id="Q9L187"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="190"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="539" mass="57499" checksum="90A524D92047053B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1L4</accession>
    <name>Q9L1L4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative extracellular solute-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5430</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629568.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030241.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5430"/>
    <dbReference type="GeneID" id="1100870"/>
    <dbReference type="KEGG" id="sco:SCO5430"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5511"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_11_0_11"/>
    <dbReference type="InParanoid" id="Q9L1L4"/>
    <dbReference type="OMA" id="YEDTFLI"/>
    <dbReference type="PhylomeDB" id="Q9L1L4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176826" evidence="1">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="458" mass="49761" checksum="FDF8B66C7EB952EB" modified="2000-10-01" version="1">MRPTVRFTALFSLTALAATSLAACSSGSGSDPDTVKVSFKQSTDNSIKVMDTYLGDIKKQFEKANPGKKVELVPIKAPDSEYYTKLQQMLRSPKTAPDLVYEDTFLINSDITSGYLKPLDDYLADWKDWDQFIDTAKAAAKGEDGKTYGVPDGTDTRGLWFSKDVFAKAGLPADWQPKTWDEVLDAARTIKEKVPGVTPLNVYTGKPAGEAATMQGFEMLLYGTGTGSGGSDPLYDKGSKKWITAGQGFEDSLSFVETVYKEKLGPEVSDALDPNFGTKVRGELLPQGKLGIALDGSWLPQDWLEGSGHEWPEWSKELGLAAMPTQNGQAPGRVSMSGGWTWAIPAKAGNPDLAFEFVKTMQTKANAQKWYVANSGISVREDVAEDPAYVDAQPGIKFFTDLVADTHYRPAYPAYPKVSVAIQEAMEGVTTGDKSVEEAARGYDEALKEATDNQVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1R9</accession>
    <name>Q9L1R9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627164.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028672.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2939"/>
    <dbReference type="GeneID" id="1098372"/>
    <dbReference type="KEGG" id="sco:SCO2939"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2997"/>
    <dbReference type="eggNOG" id="ENOG5034CE0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069241_0_0_11"/>
    <dbReference type="OMA" id="RNRACAG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28308" checksum="B20252455F54CB00" modified="2000-10-01" version="1">MVARSLRRSANGSRRHADGHTFSGETMHAVTGGTTITRGAAADVRTAVPSLVTRVRLATTVEDPARTRDAARRPQASGERPSLWNTSTLMSCLLLAVSHRAEPGTSRDLPPRFLDREFGRHRVTRFEDIDFPRTLTHEPTRRFLRETGLPEDARPFRLDADDLPLPTLAEYCEEHPDQPVPPGADHLVRLGRLADGAHVAVDGTTGAVLTWRTPDGTLHPLVSDVSALALTLWALRRAGRLETSAGGGPDYREAAAGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1U7</accession>
    <name>Q9L1U7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2947</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627171.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2947"/>
    <dbReference type="GeneID" id="1098380"/>
    <dbReference type="KEGG" id="sco:SCO2947"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3005"/>
    <dbReference type="eggNOG" id="ENOG5032RRB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142113_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L1U7"/>
    <dbReference type="OMA" id="QTKERPD"/>
    <dbReference type="PhylomeDB" id="Q9L1U7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="97" mass="10352" checksum="6F008A099B5A7B2D" modified="2000-10-01" version="1">MAVMSTLEPERGTGTGTLVEPTPQTSHGDGDHERFAHYVQKDKIMASALDGTPVVALCGKVWVPGRDPKKYPVCPMCKEIYESMSGGGDEGKGGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L266</accession>
    <name>Q9L266_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1543</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625822.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977282.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1543"/>
    <dbReference type="GeneID" id="1096969"/>
    <dbReference type="KEGG" id="sco:SCO1543"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1554"/>
    <dbReference type="eggNOG" id="ENOG5033WXW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1721400_0_0_11"/>
    <dbReference type="OMA" id="MTGVVEW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB70945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="153" mass="15809" checksum="B6805BBE00CE9A57" modified="2000-10-01" version="1">MIAETVCSAVSAAGLGIAAVTAYRRRFLTAARVAAYSLVPIGLVMTGVVEWLADTAFSPVAWAGFGVLGVAWVLFMTTRAVERRRGGTRKQRKEARAAAQRDAVAPGASAPSLGSGSGSPRPAAQPASRPAKASRGGDDDFSDIEAILKKHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCU4</accession>
    <name>Q9RCU4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral-membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0867</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625167.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027403.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0867"/>
    <dbReference type="GeneID" id="1096290"/>
    <dbReference type="KEGG" id="sco:SCO0867"/>
    <dbReference type="eggNOG" id="ENOG5033YQ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075566_1_1_11"/>
    <dbReference type="OMA" id="TAGWCCR"/>
    <dbReference type="PhylomeDB" id="Q9RCU4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176856" evidence="2">
        <location>
            <begin position="34"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="24512" checksum="885FC6B6CDE767D3" modified="2000-05-01" version="1">MSAGWCLRTTRAAVFAAVCVLLAALGHVTMSDASVPWWALAVPLVICGGAAWCLAGRERGLLPVSFAVVAAQTALHEWFSYAQALSTSPMHMDGPPEFTPSGYRPGATTHTGHAVHSLTHGESAMGATDVMDPATGIGHTVSGGMSSTGMLAAHLLAAVLTGLWLAHGERATFRVLRAVAGRLAAPLRLLLALPEPSCRPRVVLSRGRSDRRPRRPLLVYVITSRGPPEGTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD13</accession>
    <name>Q9RD13_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0898</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625197.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027426.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0898"/>
    <dbReference type="GeneID" id="1096321"/>
    <dbReference type="KEGG" id="sco:SCO0898"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.891"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406472_0_0_11"/>
    <dbReference type="OMA" id="DWGPYRP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB62689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="660" mass="70522" checksum="EA9AC4C028FA8242" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI56</accession>
    <name>Q9RI56_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0190</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37021">
        <property type="entry name" value="T37021"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026914.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0190"/>
    <dbReference type="GeneID" id="1095614"/>
    <dbReference type="KEGG" id="sco:SCO0190"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.163"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169374_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RI56"/>
    <dbReference type="OMA" id="NPGYHAH"/>
    <dbReference type="PhylomeDB" id="Q9RI56"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB53414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26624" checksum="AE736B62AB508737" modified="2000-05-01" version="1">MTLLRDHDLARAFDHASHTYDGLTALNPGYRTGLLRSARRLALPADGAGLHLLDLGCGTGASTRALLRAAPRARITAVDASAGMLRRALVKPWPARVRFLHLTAEEFATTREDEGPFDAVFAAYLFRNVTDPDAVLRAVRQLLRPGGRFAAHEYSLSGSPGHRALWSAVCRGVVIPAGTLTGDRTLYRHLRRSVVAFDTAPEFAARLTRAGLTSVRVAPVAGWQTGIVHTFLARNGGPTTTEERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIU3</accession>
    <name>Q9RIU3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0964</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625261.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027475.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0964"/>
    <dbReference type="GeneID" id="1096387"/>
    <dbReference type="KEGG" id="sco:SCO0964"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.961"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1805111_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RIU3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="143" mass="15779" checksum="D1E7D9DEEA953D4D" modified="2000-05-01" version="1">MLRRTRARLRATRWPTRWPVGGWEAGALPIVPTHGRPSTFLKLIDLARRLAEPSKHGGDASDAFTVVVPSLPRYAFSPPRPALTRRVERVEVPTAVAVFSADLTQPPRSWAGRTYNITRYASMPRGGHFAAHEESGQSGLLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIU7</accession>
    <name>Q9RIU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0959</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625256.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027470.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0959"/>
    <dbReference type="CAZy" id="GH92">
        <property type="family name" value="Glycoside Hydrolase Family 92"/>
    </dbReference>
    <dbReference type="GeneID" id="1096382"/>
    <dbReference type="KEGG" id="sco:SCO0959"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.956"/>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003690_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RIU7"/>
    <dbReference type="OMA" id="WEYGFFV"/>
    <dbReference type="PhylomeDB" id="Q9RIU7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176886" evidence="1">
        <location>
            <begin position="29"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="39"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="267"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="772" mass="84257" checksum="6B5DAF10237CF460" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY5</accession>
    <name>Q9RIY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0180</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36962">
        <property type="entry name" value="T36962"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624516.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978697.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0180"/>
    <dbReference type="GeneID" id="1095604"/>
    <dbReference type="KEGG" id="sco:SCO0180"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.153"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="InParanoid" id="Q9RIY5"/>
    <dbReference type="OMA" id="CAGRNAS"/>
    <dbReference type="PhylomeDB" id="Q9RIY5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="152"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="30108" checksum="FB7B3BB62CC77839" modified="2000-05-01" version="1">MYLPLVVGVDGSEPSLRAVDWAADEAALHAVPLWVVFGDLWERYEGAALAREPGKPSTDMQADDILAAAAIRAGRRHPDLVVTTETVPDEAEHALICAGRNASMIVMGSRGRSGIADRLLGSVSRTVAAGSDCPVVVLRGNHDNRAIGGRNGRIVVGVGEVSASVLRLAFMEARLRQVPVAAVRAWRCPAHETIDHPLPAGEPARRYEERAARELEAALEDAPPDVAVRRYTVEGPARAVLPAASAEAGLLVIGRRTQGRLGRVAHAVLHRSACPVVVVPERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJC7</accession>
    <name>Q9RJC7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative secreted beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO0766</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
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    <dbReference type="STRING" id="100226.SCO0766"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1096189"/>
    <dbReference type="KEGG" id="sco:SCO0766"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.757"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RJC7"/>
    <dbReference type="OMA" id="CLHHDQG"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176899" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="8">
        <location>
            <begin position="47"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="6">
        <location>
            <begin position="205"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="7">
        <location>
            <begin position="321"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="9">
        <location>
            <begin position="645"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="10">
        <location>
            <begin position="754"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111971" checksum="3B6DC430EA10644C" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ8</accession>
    <name>Q9RJQ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0582</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624894.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027219.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0582"/>
    <dbReference type="GeneID" id="1096005"/>
    <dbReference type="KEGG" id="sco:SCO0582"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.563"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_1_11"/>
    <dbReference type="InParanoid" id="Q9RJQ8"/>
    <dbReference type="OMA" id="EWGPLEL"/>
    <dbReference type="PhylomeDB" id="Q9RJQ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="27502" checksum="72A4CFDB26E561C9" modified="2000-05-01" version="1">MTVTSQPDQHSSADAPDLAQLLRPVVRESSVSEVAKRLLDHLSAGDIRPGTRLPAERQLAEALGVARSSVRGALSALDVLGIIEIRPGSGSYVREGTSEFLPRAINWGLMLGQRRTRDLVEVRTHMEGVSARLAAERATDADVARLEEHLQHMRDAGGDVTAFIDADIAFHLETARIARNTVLSDILHSIRALLQVWMERVSDIEGTVSGTLCEHDAVLQAIRARDPEAADRAMAEHMRMAGARLRASVDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJV0</accession>
    <name>Q9RJV0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable DNA-binding, LacI family, regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0360</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624683.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0360"/>
    <dbReference type="GeneID" id="1095783"/>
    <dbReference type="KEGG" id="sco:SCO0360"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.336"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_3_11"/>
    <dbReference type="InParanoid" id="Q9RJV0"/>
    <dbReference type="OMA" id="HTRIAWL"/>
    <dbReference type="PhylomeDB" id="Q9RJV0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB55722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="34744" checksum="A075A90CD62FB955" modified="2000-05-01" version="1">MTLSDVAAAAGVSAQTVSRVVRDPLSVSDETRARVQAALTATGYVPNLAASNLASNRSRTVAALVPQINASVFADTVHAFSTALAAHGYQIFVGTTDYRPEHEEEVLRSFLGRRPDGLLMVGTRHTPGTLTLLRAAGVPVVETWGWSRDPVDLLVGFSNAAAAAAMVGHLVERGRRRITFAGRHTSGDPRAAERLDGYTGAVRDLLGGEARTVDAGPEPVTMDTGVALLDLALERYPDSDALMFSSDVFAAGALQACVRRGIDVPGRLAVAGFGDFELARHLVPALTTVAVPSARIGELGAELLLARMRGAAVDVPHRDVGHRVVAREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKA7</accession>
    <name>Q9RKA7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3181</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627396.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028814.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3181"/>
    <dbReference type="GeneID" id="1098615"/>
    <dbReference type="KEGG" id="sco:SCO3181"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3241"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_11"/>
    <dbReference type="InParanoid" id="Q9RKA7"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="PhylomeDB" id="Q9RKA7"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018315">
        <property type="term" value="P:molybdenum incorporation into molybdenum-molybdopterin complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="195"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="424" mass="43555" checksum="DBB41602A86246B7" modified="2000-05-01" version="1">MQDHLDDVLATVRPLDPIELNLLDAQGCVLVDDITVPLSLPPFDNSSMDGYAVRVTDVAGASEEFPAVLEVVGDVAAGQTDPIAVGPGQAARIMTGAPLPPGAEAVVPVEWTDGGSGEGPVAGMRARSLAPEGAEGHVQVYRPAEERAHVRAKGSDVRSGDRALAAGTVLGPPQIGLLAAIGRGTVRVRPRPRVVVLSTGSELVQPDEQLAPGQIYDSNSFALTAAARDAGAIAYRVGAVADDAETLRATIEDQLVRADLMVTTGGVSVGAYDVVKEALAHVGDEDEPGGGVDFRKLAMQPGKPQGFGSVGPDHTPLLALPGNPVSSYVSFELFVRPAIRTLMGLPDVHRPTVTASLAADKALTSPKGRRQFLRGSHAGGSVTPVGGSGSHLVAALAQANALIVVPEDTESVEPGTEVEVVLLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-01-07" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKB5</accession>
    <name>BVMO2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Baeyer-Villiger monooxygenase</fullName>
            <shortName evidence="5">BVMO</shortName>
            <ecNumber evidence="4">1.14.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3172</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="J. Microbiol. Biotechnol." volume="17" first="1083" last="1089">
            <title>The analysis and application of a recombinant monooxygenase library as a biocatalyst for the Baeyer-Villiger reaction.</title>
            <authorList>
                <person name="Park J."/>
                <person name="Kim D."/>
                <person name="Kim S."/>
                <person name="Kim J."/>
                <person name="Bae K."/>
                <person name="Lee C."/>
            </authorList>
            <dbReference type="PubMed" id="18051317"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Thus, can convert bicyclo[3.2.0]hept-2-en-6-one into the oxidative lactone products 2-oxabicyclo[3.3.0]oct-6-en-3-one and 3-oxabicyclo[3.3.0]oct-6-en-2-one. Is also able to catalyze the sulfoxidation of methyl phenyl sulfide (thioanisole).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="4"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627388.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028809.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKB5"/>
    <dbReference type="SMR" id="Q9RKB5"/>
    <dbReference type="STRING" id="100226.SCO3172"/>
    <dbReference type="GeneID" id="1098606"/>
    <dbReference type="KEGG" id="sco:SCO3172"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3232"/>
    <dbReference type="eggNOG" id="COG2072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_7_1_11"/>
    <dbReference type="InParanoid" id="Q9RKB5"/>
    <dbReference type="OMA" id="WNTGGCT"/>
    <dbReference type="PhylomeDB" id="Q9RKB5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000431627" description="Baeyer-Villiger monooxygenase">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q47PU3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q93TJ5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18051317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="18051317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAB59668.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="56673" checksum="4031FB54427A57B4" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKI0</accession>
    <name>Q9RKI0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3452</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627656.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028993.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKI0"/>
    <dbReference type="STRING" id="100226.SCO3452"/>
    <dbReference type="GeneID" id="1098889"/>
    <dbReference type="KEGG" id="sco:SCO3452"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3512"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKI0"/>
    <dbReference type="OMA" id="PVCGNTW"/>
    <dbReference type="PhylomeDB" id="Q9RKI0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="78"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="38276" checksum="69BF8D919E3D6418" modified="2000-05-01" version="1">MATTDVSTDQQAAEASVAQSVRDYYGKVLASSADLKTTACCTDVAPPPHIAAALAEVHDEVMERFYGCGSPIPPALEGATVLDLGSGSGRDVYVLSQLVGPTGRVIGVDMTEEQLAVARRHQDWHAERFGHANTDFRHGYIEDLAGAGIPDASVDVVVSNCVVNLSPDKPRVLSEIFRVLKPGGELYFSDIFSDRRLPASLLDDPVLVGECLAGALYTEDFRRALERVGCPDARTLAASPVTISDPDIEVKIGFATFTSRTIRAFKLPLEDRCEDYGQVAVYHGTIAEHPHAFDLDDHHRLHTGKPALVCGNTADMLAATRYAAHFTVTGDKSQHFGLFPCTPAEGAAAPGLGAAPGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKP3</accession>
    <name>Q9RKP3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2285</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50594">
        <property type="entry name" value="T50594"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626533.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028250.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2285"/>
    <dbReference type="GeneID" id="1097718"/>
    <dbReference type="KEGG" id="sco:SCO2285"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2322"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_11"/>
    <dbReference type="InParanoid" id="Q9RKP3"/>
    <dbReference type="OMA" id="FINYCQY"/>
    <dbReference type="PhylomeDB" id="Q9RKP3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="140"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="351" mass="37218" checksum="7C2040E9068922C5" modified="2000-05-01" version="1">MSAVTGQKVRWGILATGGMAARFTADLVDLPDAEVVAVASRTEASAKTFAERFGIPRAYGGWETLARDEDVDVVYVATPHSAHRTAAGLCLEAGRNVLCEKPFTLNAREAAELVALARENGVFLMEAMWMYCNPLVRRLKELVADGAIGEVRSLQADFGLAGPFPAAHRLRDPAQGGGALLDLGVYPVSFAQLLLGEPTDVAARAVLSEEGVDLQTGALLSYGNDALASIHCSITGGTPNSASITGSEGRIDVPNGFFFPDHFVLHRTGRDPQEFRADPADGPRESLRHEAEEVMRALRAGETESPLVPLDGTLAVMRTLDAIRDRVGVRYPGEAGSTAQGEAADPVVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ6</accession>
    <name>Q9RKQ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Binding-protein-dependent transport lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2272</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50581">
        <property type="entry name" value="T50581"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626520.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028241.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2272"/>
    <dbReference type="GeneID" id="1097705"/>
    <dbReference type="KEGG" id="sco:SCO2272"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2309"/>
    <dbReference type="eggNOG" id="COG4558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RKQ6"/>
    <dbReference type="OMA" id="PNVGYMR"/>
    <dbReference type="PhylomeDB" id="Q9RKQ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176943" evidence="2">
        <location>
            <begin position="32"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="350" mass="35337" checksum="4234EEB71EC72D07" modified="2000-05-01" version="1">MRRLRDRLAGALLSALALTLTATGCAGSSDASSDASSDASSGAGSGAAAPSAAEPVANRVEPLGRRPEPRLPVTVRSADGERVTVDRAERIVPLSGSLSEIVFTLGLGDRVVARDVTATFEQAAKLPVVTRGHDVSAESVLSLRPDLVIAETTTGPAEAVGQIRAAGVPVLFVEAAKGLADVGPRIGAVADALGVPAAGKELTRRSEQRIEAVRKGVPHGKEPRVAFLYLRGSASVYLIGGEDSGAGSLIEAAGAVDAGAASGLGKDFTAITSEALAEAAPDAILVMSKGLASVGGVDGLVRIPGVAQTPAGMDRRIVSVEDGVLLNYGPRTDQVLKSVVAQLYGEAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKR4</accession>
    <name>Q9RKR4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2264</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50573">
        <property type="entry name" value="T50573"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626512.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028234.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2264"/>
    <dbReference type="GeneID" id="1097697"/>
    <dbReference type="KEGG" id="sco:SCO2264"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2301"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_11"/>
    <dbReference type="InParanoid" id="Q9RKR4"/>
    <dbReference type="OMA" id="AMWNQTI"/>
    <dbReference type="PhylomeDB" id="Q9RKR4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="227"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="431" mass="44742" checksum="C764A10F04105441" modified="2000-05-01" version="1">MPDEPPGGLRALLPDLSPWRASPDFRRLWVSGLITNFGSFLTFVALPVQIKELTGSAAAVGAIGAVELVPLVVFGLYGGALADAWDKRRLILWTEAGQGVACAALLVNALVPSPAVWPLYVIAAFTSALGAVQRPALDSLIPRIVAHEHLPAAASLNALRWQVGGIAGPALAGVVVAYAGLGWAYAVDLVTFAASVALVVGLASSPASHEARRPSWAAIAEGARYAWSRKELLGTYAVDLAAMLLAMPLAVLPFLADELDAEWSLGLMYAAIPAGSLLVSVSSGWTSRVHRHGRMVVLAAAGWGVAIAAAGFAGNVWLVLLCFVLAGACDMVSGVFRSAMWNQTIPDELRGRLAGIELLSYSVGPQLGQVRAGGTAALTGVRASVWSGGLLCAGAVGVLALCLPTMMTYDARTNEHAVRLREKRAADAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL05</accession>
    <name>Q9RL05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0313</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624640.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027008.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0313"/>
    <dbReference type="GeneID" id="1095737"/>
    <dbReference type="KEGG" id="sco:SCO0313"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.288"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RL05"/>
    <dbReference type="OMA" id="YNEQSQM"/>
    <dbReference type="PhylomeDB" id="Q9RL05"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
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            <end position="177"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="183"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="231"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
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        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB55670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="449" mass="47020" checksum="EB03ADD8DA87160C" modified="2000-05-01" version="1">MAARSSAPPADRSARRPAVRPYDRRRAWLVTAMIVTFMVINFADKSVLGLAAVPIMDELNISNSTYGLISSSFYLFFSLSGLVVGFFASRISSRTMLFVMALLWAVAQLPVLAVAAVPTLIAGRVLLGVAEGPAASMSMHALYKWFPPERRGLPSALQIGGAAIGTLVSAPVLTWLITDFGWRSAYAVLAVVSLLWALVWRQTGHDGPFDESRPPRADAPRPGTHLPYRRLLLTGTVLGSIASAFGAAWALALAHAWLPAYLRTQLDMSPHAVATAISAISALSLVLLLTVSPLVDALKARGVSSRWSSGAVQGASVCVAGCAMAAFPFTDGAVVRLLLIAVAFGTVAVAIPLHYVTAAEVVPGARRGAVFGIVAATGTLPGLIAPFVTGRLIDTADTASSGYTTAFLIAAAVMLLAGTAAVIAIRPEHDARRLGLLHPTTDPEKGAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL34</accession>
    <name>Q9RL34_STRCO</name>
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        <submittedName>
            <fullName evidence="2">Probable secreted solute-binding lipoprotein</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">SCO0453</name>
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    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2009-07" db="PDB data bank">
            <title>Crystal Structure of probable secreted solute-binding lipoprotein from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Damodhran L."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 36-429</scope>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="PDB" id="3I3V">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D=36-429"/>
    </dbReference>
    <dbReference type="PDBsum" id="3I3V"/>
    <dbReference type="SMR" id="Q9RL34"/>
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    <dbReference type="KEGG" id="sco:SCO0453"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.431"/>
    <dbReference type="eggNOG" id="COG1653">
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    <dbReference type="HOGENOM" id="CLU_639216_0_0_11"/>
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    <dbReference type="PhylomeDB" id="Q9RL34"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="SBP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB56683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3I3V"/>
        </source>
    </evidence>
    <sequence length="429" mass="45871" checksum="2A106E31FF2B4440" modified="2000-05-01" version="1">MRSSLTRRELLAAGSGLAAAAALPALSGCSSLASADSDPDTLVVHTQLGTTAPGSPTYLAAVDRFREENPGVKIKNLVNGDDLAQVYETSRLARKEADVVMVNLYDKTLAWTDVGATVDVKPYLDDWGLRGRVLPAALADWTDDEGRVRAFPYFATNWPVAYNRALLDRAGVDAIPTTGDQLIAAARKLRAKGIAPVTVGGNDWTGQKLLAQIIQTFLSQDEARHVYSTGDFGVRGARLGIEYFAHLRDAGVFADKAQGLTSDSMTTQFNTEEAAVQSAMSSALAKVPEKVAGHTEVGGWPLADGAAHDGPTVIRAYTLIGFWISPNGVRKIEQVEKFLRFMYRPDVVARFVTESGRDMALRTDAVSTGFPLVGAAQRLGSEVSQVLLPDVYVPPAAAQPLITATSTSFTRGTSPARVRAALESAYRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL38</accession>
    <name>Q9RL38_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible secreted solute-binding lipoprotein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">SCO0449</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624769.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027125.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0449"/>
    <dbReference type="GeneID" id="1095872"/>
    <dbReference type="KEGG" id="sco:SCO0449"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.427"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RL38"/>
    <dbReference type="PhylomeDB" id="Q9RL38"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015762">
        <property type="term" value="P:rhamnose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="RhaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02637">
        <property type="entry name" value="RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
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            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="58"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="37894" checksum="13069384EF3BF625" modified="2000-05-01" version="1">MHKTPARRASVLVAAVSSLSLLTAGCGDGDGPVDDDTAANAKNAEASPNAPTKTGLTVGFLPKQVNTPYFAVADRGGERAVESLGSTFKEVGTDQGADASGQVSHINGLTEQKADAIAVSALDPDALCDALKKAMAKGVKVVTYDSDTKPECRYAFVSPASAEDIAVRQLELLGEQTGYQGDIAILSAAQTATNQNAWISSIKRELEGPRYKEMRLVDVVYGDDEAEKSYQKAEELLREHGKLKGIISPTTNGIKAAAKYLSQSEYKGEVKLTGLGAPNDMRPYIKDGTVEAFLLWDPAKLGELAGHAAVALASGQITGREGQMFLAGDMGWFQLTGNGVITLGEPTVFDAGNIDDYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Z8</accession>
    <name>Q9S1Z8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0128</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37058">
        <property type="entry name" value="T37058"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624467.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026869.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0128"/>
    <dbReference type="GeneID" id="1095552"/>
    <dbReference type="KEGG" id="sco:SCO0128"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.105"/>
    <dbReference type="HOGENOM" id="CLU_2939647_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="60" mass="6239" checksum="2B6AF467F6CCF120" modified="2000-05-01" version="1">MICSALQREVGRQARTTAVLAAAVPVRAGQVAFPCPGGDAFWVRLVDRRLAAMQAAGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S232</accession>
    <name>Q9S232_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1768</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36871">
        <property type="entry name" value="T36871"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626039.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027963.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1768"/>
    <dbReference type="GeneID" id="1097199"/>
    <dbReference type="KEGG" id="sco:SCO1768"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1785"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S232"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="PhylomeDB" id="Q9S232"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB52832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="371" mass="40795" checksum="75E212E640D3ECF0" modified="2000-05-01" version="1">MRSSSGRNSSGNNGGSRGGNSGGRGGSSGGRGNHRGAGNNRDDKQGGRPKKPRPEERRYDVGPGATQDGPKSGRGPSARGGAKGGPKRPQQRGRSAPATSREYETRAEERNRERYAGKKDVKLPKTFPGAEQEGERLQKVLARAGYGSRRACEELIEQARVEINGEIVLEQGRRVDPEKDEVKVDGLTVATQSYQFFSLNKPAGVVSTMEDPEGRQCLGDYVTNRETRLFHVGRLDTETEGVILLTNHGELAHRLTHPRYGVKKTYLAHIVGPIPRDLGKRLKDGIQLEDGYARADHFRVVEQTGKNYLVEVTLHEGRKHIVRRMLAEAGFPVDNLVRTAFGPITLGDQKSGWLRRLSNTEVGMLMQEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S289</accession>
    <name>Q9S289_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative secreted serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO1741</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36763">
        <property type="entry name" value="T36763"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626014.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027949.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1741"/>
    <dbReference type="MEROPS" id="S01.266"/>
    <dbReference type="GeneID" id="1097172"/>
    <dbReference type="KEGG" id="sco:SCO1741"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1759"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_0_1_11"/>
    <dbReference type="OMA" id="MKHRRIP"/>
    <dbReference type="PhylomeDB" id="Q9S289"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004336910" evidence="7">
        <location>
            <begin position="34"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="9">
        <location>
            <begin position="102"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="200"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB50956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="360" mass="36366" checksum="2BFE9F0066468CC5" modified="2000-05-01" version="1">MKHRRIPRRRVAVVGAGITALVAAGVTFQTANASEAPKTAAPETLSVSAAGELASTLLGDLGADAAGTYYDAQAKSLVVNVLDQSAAQTVEEAGAKARVVENSLADLKSARTALTKDATIPGTSWATDPTTNKVVVTADRTVSEAELAKLTKVVDGLGAKAELKRTKGEYKPFVAGGDAITGGGGRCSLGFNVTKGGEPYFITAGHCTESISTWSDSSGNVIGENAASSFPDNDYGLVKYTADVDHPSEVNLYNGSSQAISGAAEATVGMQVTRSGSTTQVHDGTVTGLDATVNYGNGDIVNGLIQTDVCAEPGDSGGSLFSGDQAIGLTSGGSGDCTSGGETFFQPVTEALSATGTQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2I4</accession>
    <name>Q9S2I4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35764">
        <property type="entry name" value="T35764"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626280.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976797.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2019"/>
    <dbReference type="GeneID" id="1097453"/>
    <dbReference type="KEGG" id="sco:SCO2019"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2049"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131518_0_1_11"/>
    <dbReference type="InParanoid" id="Q9S2I4"/>
    <dbReference type="OMA" id="RFKCTQQ"/>
    <dbReference type="PhylomeDB" id="Q9S2I4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009697">
        <property type="term" value="P:salicylic acid biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="CM_bact"/>
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        <property type="entry name" value="CM_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="CHORISMATE_MUT_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="116" mass="12600" checksum="E60B5FD78E8EC47A" modified="2000-05-01" version="1">MTTSNTGTGAVEPAVREELARLRDSIDNIDAAVVHMLAERFKCTQQVGHLKARHQLPPADPAREAQQIARLRTLAESAKLDPAFAEKFLNFIVAEVIHHHERIAESNAAGGAPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2S3</accession>
    <name>Q9S2S3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2067</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35096">
        <property type="entry name" value="T35096"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626327.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976748.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2067"/>
    <dbReference type="GeneID" id="1097501"/>
    <dbReference type="KEGG" id="sco:SCO2067"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2099"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_3_11"/>
    <dbReference type="InParanoid" id="Q9S2S3"/>
    <dbReference type="OMA" id="TYDAWAM"/>
    <dbReference type="PhylomeDB" id="Q9S2S3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="28612" checksum="83FADF6BEB18118A" modified="2000-05-01" version="1">MSKRNSQAAKTAARERLRQERERQAKRDKVRRQVIVAASIVGVLAIAGGISYAVVQGNKPSGWDKAAEAKVVAPANTSGKDGTTVVIGESKSDHVIHLYEDPRCPGCAAMEQSIGETVNKGMEDGDYKLSFTVGTFLDGNLGGEGSKNALSALGAALNVSPEAFVDYKTALYSTKYHPEESTDEFAKDDYLIKVADSVDALKGNKKFQDAVEKGTYDAWAMRMSKSFDKAEGVESTPTIKINDKVVETPSTPDAWQKALKDAGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8T2</accession>
    <name>Q9X8T2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative RNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3896</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36583">
        <property type="entry name" value="T36583"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975035.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3896"/>
    <dbReference type="GeneID" id="1099332"/>
    <dbReference type="KEGG" id="sco:SCO3896"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3969"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_1_11"/>
    <dbReference type="InParanoid" id="Q9X8T2"/>
    <dbReference type="OMA" id="HRHKDVY"/>
    <dbReference type="PhylomeDB" id="Q9X8T2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="270"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="483" mass="54270" checksum="D287F80CDEB64075" modified="1999-11-01" version="1">MPNANEVSPSVLSQEQHRAAREPLRVAPVADDLARRFQEAGFSLALVGGSVRDALLGRLGNDLDFTTDARPQDVLKIMRPWADAVWEVGIAFGTVGGQKDGWQIEVTTYRSEAYDRTSRKPEVSYGDSIEEDLVRRDFTVNAMAVALPEKVFIDPHGGLDDLAARVLRTPGTPEDSFSDDPLRMMRAARFAAQLDFEVAPEVVKAMHDMAGRIDIVSAERVRDELNKLILSPHPRKGLSLLVETGLAERVLPELPALRLERDEHHRHKDVYDHTLIVLEQAMALESEGPDLTLRLAALLHDIGKPRTRRFEKDGRVSFHHHEVVGAKMTKKRMIALKYSNDLVRDVSRLVELHLRFHGYGTGEWTDSAVRRYVRDAGPLLDRLHKLTRSDCTTRNKRKASALSRAYDGLEDRIAQLQEQEELDAIRPDLDGNQIMEVLGVRPGPAVGQAYKHLLELRLENGPMEHDAAVAALKEWWAQHPDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8V8</accession>
    <name>Q9X8V8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3676</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36611">
        <property type="entry name" value="T36611"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627868.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029158.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3676"/>
    <dbReference type="GeneID" id="1099112"/>
    <dbReference type="KEGG" id="sco:SCO3676"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3735"/>
    <dbReference type="eggNOG" id="ENOG5033SMI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074113_0_0_11"/>
    <dbReference type="OMA" id="PWPKALG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="181"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB44379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="350" mass="36081" checksum="CCAA14F48CDEB7E5" modified="1999-11-01" version="1">MSQLGRKGPPERPGPARHSPGPGTFEGVAGFRIGRGRDNGAPNARPQRPPYGQQAPQGPPYGGPATPQQPYPQPPYGGGAPGPGRAPGGSPWPQAPGGGHGGGPVGGHGEPEYFGDGGYGQGGPGGHPQQAPYDPYAANNPGHTQAFTVDDPYNQGDTYRAGSAPAPGPVGPRLHWKDLLKGVILAPNQTFLQMRDYAMWAPALIVTFLYGLLAVFGFDGAREEAINATLSNAIPIVLTTAVALVLSAFVLGVVTHTLARQLGGDGAWQPTVGLSMLIMSLTDAPRLVVAMFAGGDAPFVQILGWATWVAAGALLTLMVGRSHDLPWPKALGASAIQLIALLSIVKLGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X904</accession>
    <name>Q9X904_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3722</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36657">
        <property type="entry name" value="T36657"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627914.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975218.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3722"/>
    <dbReference type="GeneID" id="1099158"/>
    <dbReference type="KEGG" id="sco:SCO3722"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3782"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_11"/>
    <dbReference type="InParanoid" id="Q9X904"/>
    <dbReference type="OMA" id="MGNEMQQ"/>
    <dbReference type="PhylomeDB" id="Q9X904"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="12675" checksum="D5FB3CA26B4E279E" modified="1999-11-01" version="1">MSTPLYQLKAEFFKTLGHPARIRVLELLSEREHAVAEMLPEVGIEPAHLSQQLAVLRRANLVVSRKEGSTVYYSLTSPQVAELLRVARGILSGVLAGQAELLADLRAGQSEPGTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA18</accession>
    <name>Q9XA18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3846</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36715">
        <property type="entry name" value="T36715"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628034.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029267.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3846"/>
    <dbReference type="GeneID" id="1099282"/>
    <dbReference type="KEGG" id="sco:SCO3846"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3916"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_3_1_11"/>
    <dbReference type="InParanoid" id="Q9XA18"/>
    <dbReference type="OMA" id="THHTSTI"/>
    <dbReference type="PhylomeDB" id="Q9XA18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB45213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="51194" checksum="5D55C14CD579113A" modified="1999-11-01" version="1">MSSTTNPSTHHTSTIGAIGAPSRRNTELALLVFAVLIPVFAYANVGLAINDEVPAGLLSYGFGLGLLAGVGHLVVRKFAPYADPLLLPLATLLNGLGLVAIWRLDQSDRLQSSKLFVEAAPRQLMYSALGVALFVAVLVFLRDHRVLQRYTYISMAGALVLLLLPLVPGLGHDNFGAKIWIKIPGLGTLQPGEFAKIVLAVFFAGYLMVKRDALALASRRFMGLYLPRGRDLGPIIVVWIISILILVFETDLGTSLLFFGMFVIMLYVATERTSWIVFGLLMSAVGAVGVASFESHVQQRVQAWLDPMHEYELSRQGVFGHTEQSMQALWAFGSGGTLGSGWGQGNSDLIGFAANSDFILATFGEELGLAGLMALLLLYALIVERGVRTALAARDPFGKLLAIGLSGAFALQVFVVAGGVMGLIPLTGMTMPFLAYGGSSVIANWALIGILLRISDTARRPAPAAPANPDAEMTQVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA65</accession>
    <name>Q9XA65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3812</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36493">
        <property type="entry name" value="T36493"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628001.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975124.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3812"/>
    <dbReference type="GeneID" id="1099248"/>
    <dbReference type="KEGG" id="sco:SCO3812"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3880"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_1_11"/>
    <dbReference type="InParanoid" id="Q9XA65"/>
    <dbReference type="OMA" id="IFEMFSI"/>
    <dbReference type="PhylomeDB" id="Q9XA65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12684" checksum="D16A86761F686586" modified="1999-11-01" version="1">MLLSLDKTDTRPLHEQVAGALRRAIAEGECAPGDRLPSARDLSEALDVNVNTVLRALRGLRDEGLLEFRRGRGVTVAEGARPHSELQIRVRELLAEAARLGYSRTDLIDMIRGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI0</accession>
    <name>Q9XAI0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3622</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35390">
        <property type="entry name" value="T35390"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627817.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029123.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3622"/>
    <dbReference type="GeneID" id="1099058"/>
    <dbReference type="KEGG" id="sco:SCO3622"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3681"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAI0"/>
    <dbReference type="OMA" id="PLVPYNA"/>
    <dbReference type="PhylomeDB" id="Q9XAI0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="451" mass="48414" checksum="43CF2DD9AFA7E8AB" modified="1999-11-01" version="1">MTPQPSPQAGAAVKAADRAHVFHSWSAQELIDPLAVAGAEGSYFWDYEGKRYLDFSSGLVYTNIGYQHPKVVAAIQEQAARMTTFAPAFAVEARSEAARLIAERTPGDLDKIFFTNGGADAVEHALRMARLHTGRPKVLSAYRSYHGGTQQAVNVTGDPRRWASDSGTAGVVHFWAPFLYRSRFYAETEEQECARALEHMETTIAFEGPGTIAAIVLETIPGTAGIMMPPAGYLAGVREICDKYGIVFVLDEVMAGFGRTGTWFAADLYDVVPDLMTFAKGVNSGYVPLGGVAISAEIAATFAERPYPGGLTYSGHPLACAAAVATINVMAEEGVVEHAARLGAEVVEPALRELAERHPSVGEVRGTGMFWALELVRNRETREPLVPYNATGQAATPMSAFAASAKAHGLWPFVNMNRTHVVPPCNVSEAELKEGLAALDTALSVADEYTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4W7</accession>
    <name>TRPE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Anthranilate synthase component 1</fullName>
            <shortName>AS</shortName>
            <shortName>ASI</shortName>
            <ecNumber>4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trpE</name>
        <name type="ordered locus">SCO3214</name>
        <name type="ORF">SCE8.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Feedback inhibited by tryptophan.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36306">
        <property type="entry name" value="T36306"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627428.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028832.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z4W7"/>
    <dbReference type="SMR" id="Q9Z4W7"/>
    <dbReference type="STRING" id="100226.SCO3214"/>
    <dbReference type="GeneID" id="1098648"/>
    <dbReference type="KEGG" id="sco:SCO3214"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3274"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_11"/>
    <dbReference type="InParanoid" id="Q9Z4W7"/>
    <dbReference type="OMA" id="NISRAWH"/>
    <dbReference type="PhylomeDB" id="Q9Z4W7"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154113" description="Anthranilate synthase component 1">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="328"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>chorismate</name>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="511" mass="54829" checksum="FA3265656CA4D488" modified="1999-05-01" version="1">MTTHAAEAPTTDPQGAPGSQKTPDATEAEEAARATVPHRAAAAALAREHDVVPLHQEFLDDSVSPVTAFAQLCGPDEAGFLLESVPVSGGVARYSYVGHRPVPLEPTGGDPLTALRSHLARSVAPVPGLPPFHGGVVGYLGYEAARHFEDLPLAAGPPPGLPESAFLAADDLVVFDHATRRVLLMTLYRPARESYDDAVARIVRLNRALRRAPAPAAFSGRPLAAATPADHGTQGWTANLTEAQFTERVARAREHIAAGDAFQIVLSRRLSRPLRARPTDLYRHLRATNPSPYMYHLSLGGGRHVIGASPELLVKAEGRTVRTRPLAGTRPRHPDPAEDLRLERELRADEKERAEHVMLVDLGRNDLGRVTEPGTVRVERLMRVERFSHVMHLSSTVRGRLAEGRDALDALRSAFPAGTLSGAPKIRAMEIIAELEPEQRGVYGGALGFVGADGLTDFAIALRTMVVADGHVHVQAGAGIVADSDPAAEFRETLHKSRAMLTAVRRAEAAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z513</accession>
    <name>Y1952_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein SCO1952</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1952</name>
        <name type="ORF">SCC54.12c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>The whiA sporulation regulatory gene of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Ryding N.J."/>
                <person name="Ainsa J.A."/>
                <person name="Hartley N."/>
                <person name="Bruton C.J."/>
                <person name="Chater K.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAD42167" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB38142" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AF106003">
        <property type="protein sequence ID" value="AAD42167.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38142.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36025">
        <property type="entry name" value="T36025"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626216.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z513"/>
    <dbReference type="SMR" id="Q9Z513"/>
    <dbReference type="STRING" id="100226.SCO1952"/>
    <dbReference type="GeneID" id="1097386"/>
    <dbReference type="KEGG" id="sco:SCO1952"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1978"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z513"/>
    <dbReference type="PhylomeDB" id="Q9Z513"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000107768" description="Nucleotide-binding protein SCO1952">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="299" mass="32821" checksum="E69CE8455948B7CD" modified="2003-04-23" version="2">MSTGKETAGAHEAAIPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVELGARSQGNVARIAVVVDVRGRRFFDNLRESLADLDARGVTRRIVFLESSDDALVRRFESVRRPHPLQGDGRIVDGIAAERELLRELRGDADLVIDTSSLNVHELRAKMDAQFAGDQEPELRATVMSFGFKYGLPVDADLVVDMRFLPNPHWVPELRPFTGLNEEVSSYVLNQPGAKEFLDRYAELLQLIAAGYRREGKRYVTVAVGCTGGKHRSVAMSEKLAARLAAEGVETVVVHRDMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z517</accession>
    <name>Q9Z517_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-binding carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1948</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36021">
        <property type="entry name" value="T36021"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626212.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028058.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1948"/>
    <dbReference type="GeneID" id="1097382"/>
    <dbReference type="KEGG" id="sco:SCO1948"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1975"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012481_0_0_11"/>
    <dbReference type="OMA" id="REWITPE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177068" evidence="2">
        <location>
            <begin position="28"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB38138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="999" mass="106800" checksum="E397A5EF1457A04F" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z518</accession>
    <name>G3P_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="3">GAPDH</shortName>
            <ecNumber evidence="3">1.2.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">gap</name>
        <name type="ordered locus">SCO1947</name>
        <name type="ORF">SCC54.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text>Resistant to pentalenolactone.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36020">
        <property type="entry name" value="T36020"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626211.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976871.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z518"/>
    <dbReference type="SMR" id="Q9Z518"/>
    <dbReference type="STRING" id="100226.SCO1947"/>
    <dbReference type="PRIDE" id="Q9Z518"/>
    <dbReference type="GeneID" id="1097381"/>
    <dbReference type="KEGG" id="sco:SCO1947"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1974"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_11"/>
    <dbReference type="InParanoid" id="Q9Z518"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="PhylomeDB" id="Q9Z518"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000145701" description="Glyceraldehyde-3-phosphate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P54226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P9WN83"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="336" mass="36268" checksum="91C17A1EB1EE3C18" modified="1999-05-01" version="1">MTIRVGINGFGRIGRNYFRALLEQGADIEIVAVNDLGDTATTAHLLKYDTILGRLKAEVSHTEDTITVDGKTIKVLSERNPADIPWGELGVDIVIESTGIFTKKADAEKHIAGGAKKVLISAPAKDEDITIVMGVNQDKYDPANHHVISNASCTTNCVAPMAKVLDENFGIVKGLMTTVHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKLDGIAMRVPVPTGSATDLVVELQREVTKDEVNAAFKKAADDGDLKGILFYTEDAIVSSDITGDPASCTFDSSLTMVQEGKSVKILGWYDNEWGYSNRLVDLTVFVGNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBK0</accession>
    <name>Q9ZBK0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6474</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35961">
        <property type="entry name" value="T35961"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630557.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972504.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6474"/>
    <dbReference type="GeneID" id="1101913"/>
    <dbReference type="KEGG" id="sco:SCO6474"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6574"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBK0"/>
    <dbReference type="OMA" id="EAIFPDH"/>
    <dbReference type="PhylomeDB" id="Q9ZBK0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="29751" checksum="7BF0CB87826C0AE6" modified="1999-05-01" version="1">MSQPAKSSRTSATPDAPESAAGSRAAAQRLKMRRELAAAAMELFATKGYEATTVDEIAAQAGVARRTFFRHFRSKEEAIFPDHDDTLVRAEAVLNAAPAHEHPLDTVCRGIKEVMKMYAARPEISVARYKLTREVPTLREAEIASVARYERLFTRYLLGHFDEHAHDDDANDDPLLAEVAASAVVTAHNHVLRRWLRADGQGDVEAELDHAFAIVRRTFGTGIGAGRSTASTARPAVSSSASVQGEVLVTVARTDAPLHEVMRTIEQALKER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O50490</accession>
    <name>O50490_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5772</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35142">
        <property type="entry name" value="T35142"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629897.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030444.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5772"/>
    <dbReference type="GeneID" id="1101214"/>
    <dbReference type="KEGG" id="sco:SCO5772"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5862"/>
    <dbReference type="eggNOG" id="COG5553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102185_1_0_11"/>
    <dbReference type="InParanoid" id="O50490"/>
    <dbReference type="OMA" id="EAWLIGW"/>
    <dbReference type="PhylomeDB" id="O50490"/>
    <dbReference type="BRENDA" id="1.13.11.20">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="O50490"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174825" evidence="3">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA15878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="182" mass="19716" checksum="2A5CE277F0764305" modified="1998-06-01" version="1">MSLPSVSPASPVSASASTPAPTQAQLLDFVRRAAADAQLVASLPLDPEGRTWMRLAGPGGSEAWLIGWPPGTGTGWHDHADSVGAFVTAAGELKENALAARLPTDGWKTLELSDGVDRERRLSVGTGRAFGRHHVHEVLNESSDRHAVSVHAYYPPLPQIRRYSRSGQTLRLEQVERPQDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O54115</accession>
    <name>O54115_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5919</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34591">
        <property type="entry name" value="T34591"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630037.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030532.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5919"/>
    <dbReference type="GeneID" id="1101361"/>
    <dbReference type="KEGG" id="sco:SCO5919"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6017"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151990_0_0_11"/>
    <dbReference type="OMA" id="HDGRCEG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA16456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="134" mass="14279" checksum="A89F22BE1027833E" modified="1998-06-01" version="1">MTPGQLQDRSVGALPLRGTVADVMDAAGPQVWYDMTVEVALSVMAAARAEHLVVCDEDARCVGLVTQARLTAVRDSSRYTDRLRLGDITDDSEPFVSPSATREEAEDAVPFGRLGLVPVVDEHGSALGVLALSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O54134</accession>
    <name>DUT_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dut</name>
        <name type="ordered locus">SCO5868</name>
        <name type="ORF">SC2E9.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34820">
        <property type="entry name" value="T34820"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629990.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973153.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54134"/>
    <dbReference type="SMR" id="O54134"/>
    <dbReference type="STRING" id="100226.SCO5868"/>
    <dbReference type="GeneID" id="1101310"/>
    <dbReference type="KEGG" id="sco:SCO5868"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5967"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_3_11"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="PhylomeDB" id="O54134"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182910" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="183" mass="19084" checksum="73A1AF674C64F293" modified="1998-06-01" version="1">MSRAGLEVLIRRVDPDVPLPAYAQPGDAGADLRTTVERELAPGERAVLPTGVSVALPEGYAAFVHPRSGLAARCGVALVNAPGTIDAGYRGEIKVIVVNLDPRESVRFERFDRIAQLVVQQVERVRFRQVAELPGSARAEGGFGSTGGHAGLDPASGTSGQVAEGGPTGGNRYASVVSDREGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O54190</accession>
    <name>CBIM_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalt transport protein CbiM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Energy-coupling factor transporter probable substrate-capture protein CbiM</fullName>
            <shortName evidence="1">ECF transporter S component CbiM</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbiM</name>
        <name type="ordered locus">SCO5961</name>
        <name type="ORF">SC7H1.31c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbiM family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAA16218" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16218.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35726">
        <property type="entry name" value="T35726"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630078.2">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030567.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54190"/>
    <dbReference type="SMR" id="O54190"/>
    <dbReference type="STRING" id="100226.SCO5961"/>
    <dbReference type="GeneID" id="1101403"/>
    <dbReference type="KEGG" id="sco:SCO5961"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6058"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_3_0_11"/>
    <dbReference type="InParanoid" id="O54190"/>
    <dbReference type="PhylomeDB" id="O54190"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01462">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00123">
        <property type="entry name" value="cbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0171">Cobalt transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000411149" description="Cobalt transport protein CbiM">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="232" mass="24456" checksum="D195D029569BCB95" modified="2011-07-27" version="2">MHIAEGFLPPAHAIAWGVASAPFVVHGVRSLTREVREHPESTLLLGASGAFTFVLSALKLPSVTGSCSHPTGTGLGAILFRPPIMAVLGTITLLFQALLLAHGGLTTLGANVFSMAIVGPWAGYGVYRLLRRWDVPLMVTVFFGAFVADLSTYCVTSVQLALAFPDPSSGFLGALGKFGSIFAVTQIPLAVSEGLLTVIVMRLLVQSSKGELTRLGVLLTRTGERKQEAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O70003</accession>
    <name>O70003_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5827</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35201">
        <property type="entry name" value="T35201"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629950.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5827"/>
    <dbReference type="GeneID" id="1101269"/>
    <dbReference type="KEGG" id="sco:SCO5827"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5924"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_3_11"/>
    <dbReference type="InParanoid" id="O70003"/>
    <dbReference type="OMA" id="RATTWIQ"/>
    <dbReference type="PhylomeDB" id="O70003"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043879">
        <property type="term" value="F:glycolate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006847">
        <property type="term" value="P:plasma membrane acetate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
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        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA18525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="54929" checksum="3368854A30C98BDB" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O70008</accession>
    <name>O70008_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5832</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAA18530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T35206"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629955.1">
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    </dbReference>
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    <dbReference type="GeneID" id="1101274"/>
    <dbReference type="KEGG" id="sco:SCO5832"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5929"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_11"/>
    <dbReference type="InParanoid" id="O70008"/>
    <dbReference type="OMA" id="LTYCGYD"/>
    <dbReference type="PhylomeDB" id="O70008"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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    </dbReference>
    <dbReference type="GO" id="GO:0006099">
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    </dbReference>
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        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA18530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="390" mass="41378" checksum="36365F025C7E097A" modified="1998-08-01" version="1">MSVNRTAAAATPVEVPRGLAGVVVADTEVGDVRGLEGFYHYRQYSAVELARSRGFEDVWHLLVHGELPDARTGAAFAAETAALRRLPDAVRAALPAIAEAGAGSGPLAGMRTGLSLLGAALGFRPVYDLSVDQRRQDTLVAAAAVPTLLTALHRLGRGLEPVEPREDLSYAANYLYMLTGQEPDEACTRAIEQYLISTIDHGFNASTFTARVIASTGADVAACLAGAVSALSGPLHGGAPSRALDTLDAIGTPDRIDAWIRERVLAGDRIMGFGHAVYRTEDPRSRMLREVAQSFGGPRVEFAVEVERQVEAILAELKPGRELHTNVEFYAGVVMELCGLPREMFTPTFAAARVVGWSANILEQASDSKIIRPAARYVGPGAPVGVPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O86607</accession>
    <name>O86607_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6338</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29424">
        <property type="entry name" value="T29424"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630430.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030839.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6338"/>
    <dbReference type="GeneID" id="1101779"/>
    <dbReference type="KEGG" id="sco:SCO6338"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6451"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_33_0_11"/>
    <dbReference type="InParanoid" id="O86607"/>
    <dbReference type="OMA" id="GARTNIT"/>
    <dbReference type="PhylomeDB" id="O86607"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="95" mass="10626" checksum="50659326945D1322" modified="1998-11-01" version="1">MGTSKYSPEFRADAVALYHASPGGTYASVAKDLGVNHETLRTWVRDAEQAGRPGAVEATAMDKENRQLRARVKELELEREILRRAAKYFAAETSW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O86624</accession>
    <name>O86624_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6355</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29446">
        <property type="entry name" value="T29446"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630447.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030852.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6355"/>
    <dbReference type="GeneID" id="1101796"/>
    <dbReference type="KEGG" id="sco:SCO6355"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6467"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_2_0_11"/>
    <dbReference type="InParanoid" id="O86624"/>
    <dbReference type="OMA" id="WSVGHRP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="91"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="28296" checksum="094EF3A0E790D4C7" modified="1998-11-01" version="1">MKRGDVAELAGSCGLGAWTAFGVLTMAVVGHDGMALFADADILAWSVGHRPDVAVAFARGLTDTGTGLVPYALAVLAALIAGRTPRQRALAIPLCLGCLGAGQALRYAVMALVARPRPPLTDWATHASGWSFPSGHTTTAALTAGLLIIAVRVRGPRGTTPLTLVIGGWGASVGLTRVYLGVHWFTDVVGGWLFALGWLGLCLWAVAHWLPDRWTPGTTDTDTDSARGTAEPTGSTAGGRTHTAPEQTDVARGQREGHAPDDPGRRGRSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>O86646</accession>
    <name>O86646_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5727</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T10922">
        <property type="entry name" value="T10922"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629853.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030419.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5727"/>
    <dbReference type="GeneID" id="1101166"/>
    <dbReference type="KEGG" id="sco:SCO5727"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5817"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1365520_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="22641" checksum="1C4CD5C5D0E4418A" modified="1998-11-01" version="1">MTDKRFLFCRIWIAPEDTVEDWVPGKPAELDRLIKRLGGAAAHFREGAEKLRKLNTDPCRARLSRSSARRSRNCPRNSMVPRTRSLRRASPYSPTAKCLRVQRLTRQILDHEAPTARDLSRQYARAVDDYYVAIKAGDTKLPTRPPETNPGRTAKAELIERINSAQGEVTEAAGIAKRTLHKAAGRVVPEVTGFQSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>O86759</accession>
    <name>O86759_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5640</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35458">
        <property type="entry name" value="T35458"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629770.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030356.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5640"/>
    <dbReference type="GeneID" id="1101079"/>
    <dbReference type="KEGG" id="sco:SCO5640"/>
    <dbReference type="HOGENOM" id="CLU_1694487_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="17110" checksum="9B6E7E703D8A6403" modified="1998-11-01" version="1">MTREVEQVLADLEAWAGAVESNTPSFKSSLTAQQMRAVSVRVANQLRDPSQKLHDSGVRFAETAEKADAVMNSIKDQISRVSDQEQRDALKAVVIPADRSTDLNEVANNMAELLDSMTSVEMMSAPLRKSLKPARIGITKIQDAARIVNRWLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O86760</accession>
    <name>O86760_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1863 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5639</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35459">
        <property type="entry name" value="T35459"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629769.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030355.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5639"/>
    <dbReference type="GeneID" id="1101078"/>
    <dbReference type="KEGG" id="sco:SCO5639"/>
    <dbReference type="eggNOG" id="ENOG5030DRP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115337_0_0_11"/>
    <dbReference type="OMA" id="RKHVDWE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015032">
        <property type="entry name" value="MTH538_TIR-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08937">
        <property type="entry name" value="DUF1863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1863" evidence="1">
        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="176" mass="20433" checksum="18665FD150A58E60" modified="1998-11-01" version="1">MEIAQVRRKCFISYHHEDEREVHQFIQKFDHVRDIFIARGIGAGMPGDVLNSNNRDYIMRRVRALYLGNSTVTIVMVGKCTWARRYVDWEIASTLRDDVRNKRGGLLGIVLPSAVNSPKAPPRLKDNLESGYAEWYHYPTSAAQLSRMIETAYSAREELKPKNDRLLFSYNRECRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O86777</accession>
    <name>O86777_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35561">
        <property type="entry name" value="T35561"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628890.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029828.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4732"/>
    <dbReference type="GeneID" id="1100173"/>
    <dbReference type="KEGG" id="sco:SCO4732"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4803"/>
    <dbReference type="eggNOG" id="ENOG5033WXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071800_0_0_11"/>
    <dbReference type="OMA" id="QSQWDPW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="31038" checksum="32543C0C1AA10E95" modified="1998-11-01" version="1">MSFGQGGPQSQWDPWTPQSQQPPSQQPWNSGNSDDTPDWAALAEASEARAKRRRLFFIGGGALATVAIAGAVAVAVVSANGSDQASDGGSSQLPTTAEIPSATATEPSFAPTSAPPPLDPKDFVSSVKKDKAPLSPDLLFPGTQLTMGETVYKKGPTADTRTCGSAAQGTLPKVLDANRCTRLIRVTYTQGDTAVTVGVAVFDTEAQAAKAKKDADKKSIVRSLSGGGVKSFCTGAVCRSTTNSYGRYAYFTVAGFTGAKDVTEKSTGVFRAGDDLAEFAFRQIRRRGEAQASAAAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O87841</accession>
    <name>O87841_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">SCO6586</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35774">
        <property type="entry name" value="T35774"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630665.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031023.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6586"/>
    <dbReference type="GeneID" id="1102025"/>
    <dbReference type="KEGG" id="sco:SCO6586"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6691"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_11"/>
    <dbReference type="InParanoid" id="O87841"/>
    <dbReference type="OMA" id="GEGMKHT"/>
    <dbReference type="PhylomeDB" id="O87841"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA19779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="308" mass="31427" checksum="161BD149DBBB31EB" modified="1998-11-01" version="1">MAIYLTKESKVLVQGMTGAEGMKHTRRMLAAGTDVVGGVNPRKAGRTVDFDNRTVPVFGSVREGIERTGADVTVVFVPPAFAEAAVVEAADAGVGLAVVITEGIPVHDSVALTAHARAKGTRVIGPNCPGLITPGQSNAGIIPPDITKPGRIGLVSKSGTLTYQLMYELRDIGFSTCVGIGGDPVVGTSHIDCLAAFEDDPDTELIVLIGEIGGDAEERAAAHIRAHVTKPVVAYIAGFTAPEGRTMGHAGAIVSGSSGTARAKKEALESVGVRVGSTPTETARHVLQALDVPGGAAPDGAARDGARA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O88011</accession>
    <name>RIBA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="1">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribA</name>
        <name type="ordered locus">SCO6655</name>
        <name type="ORF">SC5A7.05</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="1"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35154">
        <property type="entry name" value="T35154"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630730.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031080.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O88011"/>
    <dbReference type="SMR" id="O88011"/>
    <dbReference type="STRING" id="100226.SCO6655"/>
    <dbReference type="GeneID" id="1102094"/>
    <dbReference type="KEGG" id="sco:SCO6655"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6761"/>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_1_11"/>
    <dbReference type="InParanoid" id="O88011"/>
    <dbReference type="OMA" id="GQGFILY"/>
    <dbReference type="PhylomeDB" id="O88011"/>
    <dbReference type="BRENDA" id="3.5.4.25">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000151777" description="GTP cyclohydrolase-2">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <sequence length="221" mass="24087" checksum="DF84EB1B3EEDAA32" modified="1998-11-01" version="1">MTEKIGVLGKKTTQRTDVERIVVTPLPTVYGKFRAFGYFDHERGDEQVALVHGDLGAEDVLTRLHSECLTGDAFGSQHCECGAQLASALRQVADAGSGIVVYLRGHEGRGIGLLAKLRAMALQAEGLDTVEANLALGLPVDARDYGVAARILDDLGVRSVRLMSNNPRKREALVRHGIRVAEQVPLLIPPCESNITYLRTKRERLDHHLPHLDAAMAHVSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>P40183</accession>
    <name>HSPR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative heat shock protein HspR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hspR</name>
        <name type="ordered locus">SCO3668</name>
        <name type="ORF">SCH44.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Microbiol." volume="17" first="663" last="674">
            <title>The dnaK operon of Streptomyces coelicolor encodes a novel heat-shock protein which binds to the promoter region of the operon.</title>
            <authorList>
                <person name="Bucca G."/>
                <person name="Ferina G."/>
                <person name="Puglia A.M."/>
                <person name="Smith C.P."/>
            </authorList>
            <dbReference type="PubMed" id="8801421"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1995.mmi_17040663.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Binds to three inverted repeats (IR1-IR3) in the promoter region of the dnaK operon.</text>
    </comment>
    <comment type="induction">
        <text>By heat shock.</text>
    </comment>
    <dbReference type="EMBL" id="L46700">
        <property type="protein sequence ID" value="AAB29454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB91159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S70209">
        <property type="entry name" value="S70209"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975271.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40183"/>
    <dbReference type="SMR" id="P40183"/>
    <dbReference type="STRING" id="100226.SCO3668"/>
    <dbReference type="GeneID" id="1099104"/>
    <dbReference type="KEGG" id="sco:SCO3668"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3726"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_7_1_11"/>
    <dbReference type="InParanoid" id="P40183"/>
    <dbReference type="OMA" id="GRRYSEH"/>
    <dbReference type="PhylomeDB" id="P40183"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000098127" description="Putative heat shock protein HspR">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00254"/>
        </source>
    </evidence>
    <sequence length="151" mass="16939" checksum="A0675EB251CCD4EC" modified="1997-11-01" version="2">MDGRRRNPYELTEDTPVYVISVAAQLSGLHPQTLRQYDRLGLVSPDRTAGRGRRYSARDIELLRQVQQLSQDEGINLAGIKRIIELENQVAELQARAAELAAALDGAATAMRQREAAVHASYRRDLVPYQEVQQTSALVVWRPSRRGQSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKR4</accession>
    <name>Q7AKR4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0777</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625079.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978084.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKR4"/>
    <dbReference type="STRING" id="100226.SCO0777"/>
    <dbReference type="GeneID" id="1096200"/>
    <dbReference type="KEGG" id="sco:SCO0777"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.768"/>
    <dbReference type="eggNOG" id="COG0435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_1_0_11"/>
    <dbReference type="InParanoid" id="Q7AKR4"/>
    <dbReference type="OMA" id="PWANRAI"/>
    <dbReference type="PhylomeDB" id="Q7AKR4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="157"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="38106" checksum="6F3732F0D48A70DC" modified="2004-07-05" version="1">MSGDDGTPGNSGYGKKAFKRSRSHFADRITADGRDGWPVEAGRYRLVVSRACPWASRALVSRRLLGLEDALSLAVADPVQDDRSWRFTLDPDGRDPVLGIRYLGEAYDRRETGYPGGVSVPAVVDVPSGALVTNDYQQITLDLATEWTALHRPGAPDLYPRALRDEIDEVMAGVYEDVNNGVYRAGFATGQEEYEAACAGVFRRLEQLTPRLERQRYLVGDTITEADIRLFTTLVRFDAVYHGHFKCNRWKLTENPVLWAYVRDLFQTPGFGDTVDFDHIKRHYYQVHTGINPTGIVPLGPDLAGWLTPHHRQELGGRPFGEGTPPEPVRAEEEVPARGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKR5</accession>
    <name>Q7AKR5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0775</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978086.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0775"/>
    <dbReference type="GeneID" id="1096198"/>
    <dbReference type="KEGG" id="sco:SCO0775"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.766"/>
    <dbReference type="eggNOG" id="COG4405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114921_1_0_11"/>
    <dbReference type="InParanoid" id="Q7AKR5"/>
    <dbReference type="OMA" id="NPVWYYN"/>
    <dbReference type="PhylomeDB" id="Q7AKR5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="149" mass="16702" checksum="6AC715481A3C6761" modified="2004-07-05" version="1">MPLDGEYEPSPTQWVREQVERYESSGGTEGTTLMDTGLPVIVLTTRGARSGKLRKTPLMRVEHEGRYAVVASLGGAPKHPVWYFNVKADPRVELQDGPVKQDMTAREVTGAEKARWWERAVAAYPSYADYQKKTEREIPVFVLEPSHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJR9</accession>
    <name>Q8CJR9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5277</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAD55346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733659.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030147.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5277"/>
    <dbReference type="GeneID" id="1100718"/>
    <dbReference type="KEGG" id="sco:SCO5277"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5362"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_0_1_11"/>
    <dbReference type="InParanoid" id="Q8CJR9"/>
    <dbReference type="OMA" id="RISAVCG"/>
    <dbReference type="PhylomeDB" id="Q8CJR9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="34164" checksum="803A20E14D905F36" modified="2003-03-01" version="1">MPEPRILPYSRVVAQDELKLALELHHVVPRIGGVLMAGPRGTAKSTLVRAFALMAHGELPVTLPINATDDRVVGGWDLDALIRGEPRPQPGLLEDAADKGLLYVDEVNLLDDHLVDIILDVAATGVLSVQREGLDTAKYLSFGLVGTMNPEEGGLRPQLLDRFGLMVTAETLDATARHLLLRTVLDFELELEREDSAWLSAARRDDARTRDRLTAARRRVRDVDVPDHVLELCARAAERTEAVGQRGEIVAVLAARALAALEDADRVTPGHLRRVLPMALRHRRPEAVHGDTFDWEPDDEARLQDLFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJT8</accession>
    <name>Q8CJT8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="3">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purU</name>
        <name evidence="5" type="ordered locus">SCO4403</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurU family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="3"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAD55482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733636.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974579.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4403"/>
    <dbReference type="GeneID" id="1099843"/>
    <dbReference type="KEGG" id="sco:SCO4403"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4471"/>
    <dbReference type="eggNOG" id="COG0788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_11"/>
    <dbReference type="InParanoid" id="Q8CJT8"/>
    <dbReference type="OMA" id="HADHHTD"/>
    <dbReference type="PhylomeDB" id="Q8CJT8"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="32830" checksum="74D2F5C42FB497F6" modified="2003-03-01" version="1">MNAQSSAAVPSADAPADQYVLTLSCPDKQGIVHAVSSYLFMTGCNIEDSQQFGDHDTGLFFMRVHFSAGEPVTVDKLRASFTAIGDAFHMDWQINRADAKTRIVLMVSRFGHCLNDLLFRARIGALPVEIAAVVSNHTDFAELVGSYDIPFHHIPVTKDTKPEAEARVLEIVREENVELVVLARYMQVLSDDLCKALSGRIINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVERVGHDVTPDQLVAIGRDVECQALARAVKWHAERRILLNGRRTVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJU8</accession>
    <name>Q8CJU8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4109</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAD55471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733626.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974864.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4109"/>
    <dbReference type="GeneID" id="1099546"/>
    <dbReference type="KEGG" id="sco:SCO4109"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4169"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="InParanoid" id="Q8CJU8"/>
    <dbReference type="OMA" id="HVDREGT"/>
    <dbReference type="PhylomeDB" id="Q8CJU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="33371" checksum="AFAC7C80149ADF44" modified="2003-03-01" version="1">MTSLRKLGSSDLEVFPLALGGNVFGWTADRDRSFAVLDAYTAAGGNFVDTADSYSAWVDGNSGGESETVLGQWFAARGNRDDVVLATKVSQHPEYPGLSAANIKAAADASLRRLGTDHIDLYYTHFDKPEVPVEEIIGALDELVKAGKVRHIAASNISAERLAASLEFSDREGLARYVALQPHYNLVSRDTYEGELRDLAEQAGLAAVPYYALAAGFLTGKYRPGTEVDSPRAGGAAKHLETERGRRVLAALDEIAAAHEAPVATVALAWLAARPTVAAPIASARTVEQLPALLGVAELILTDDEVGRLTRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJV8</accession>
    <name>Q8CJV8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3723</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAD55330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36658">
        <property type="entry name" value="T36658"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733615.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029190.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3723"/>
    <dbReference type="GeneID" id="1099159"/>
    <dbReference type="KEGG" id="sco:SCO3723"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3783"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_8_11"/>
    <dbReference type="InParanoid" id="Q8CJV8"/>
    <dbReference type="OMA" id="GHLIHHP"/>
    <dbReference type="PhylomeDB" id="Q8CJV8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="105"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="275"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="498" mass="52761" checksum="BB703FAFDB0C4B35" modified="2003-03-01" version="1">MMAEERRHAPDEPASADVDSGGGSAADSAAELPEGPGSGPAQGSGEGPAAAPGRGGDDEPYASLLDLPLSSDLNRIGEQLHALARAQRTLQELLQAVVNITGELELPAVLRRIVRTAMDLVGARYGAMGVLDQEGRLLEEFIPLGLTTKELADLEGVELPRGRGLLGHLIHHPEPLRVKDISRHPESAGFPPGHPPMRSLLGVAISVRGRIYGNLYLSERKDGQPFDRHDEGVIRALAGTAGVAIENARLYQQVRNSSEQFQRLLLPRLPDLRPFTAGAAYRPASAPAAVGGDWYDAMLLPGGACAAVIGDVVGHDLRAAADMSQIRNMLRALYYDPGAAPSTSLARLDRIMNAALDEAPVATALLARLEPADGTWQLRWSSAGHPPPLVLLPDGRVRYLDMEPGLPLGVAPDLPRPDHCRPLPVDSTVILFTDGLVEVPGQPLDRGLDALAVTASRLVGLAPEDLCHALVAHRPGNGHDDKAVIALRTPPLTSYGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWE5</accession>
    <name>Q8VWE5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.04c</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639748.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039581.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095048"/>
    <dbReference type="KEGG" id="sco:SCP2.04c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8298"/>
    <dbReference type="HOGENOM" id="CLU_852362_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="35276" checksum="B7610017F9492845" modified="2002-03-01" version="1">MSRRSLALPSTRSTEPDDADELEAAPEEKLAAARSAGVVASLTGADLSTPLTVAQLPTPYDVAETVTAPLNDQERGYLDVCEQALHGFRKSVVVAGKALEVINRGRLYRETHETFADYVTEVWDMKRAHAYRMIEGWRPADLVSPIGDINEGQARELAPVLKEYGPEVTVTLYRGVKELRGDRRVTAADLSEARAALPPPKHLARPDQVRDVLTVAAAEGRAPRLAPAEPKVPAQAADEHQAEQVDEGGVSQDQVDEGAEAIATLEAAVAQQRQIYDRVGGGTLAAALLYDPGRGDHLRRELRQYAQRTAYRARDTSGEQVADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IY1</accession>
    <name>Q93IY1_STRCO</name>
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        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5104</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030059.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5104"/>
    <dbReference type="GeneID" id="1100545"/>
    <dbReference type="KEGG" id="sco:SCO5104"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5185"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_3_11"/>
    <dbReference type="InParanoid" id="Q93IY1"/>
    <dbReference type="OMA" id="LYRREHE"/>
    <dbReference type="PhylomeDB" id="Q93IY1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
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    <dbReference type="InterPro" id="IPR036890">
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    <dbReference type="InterPro" id="IPR035965">
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    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
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        <property type="entry name" value="PPM-type_dom_sf"/>
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        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08448">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="880" mass="94779" checksum="4EB9867390CB436E" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF3</accession>
    <name>Q93JF3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane ion exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5974</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630090.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030576.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5974"/>
    <dbReference type="GeneID" id="1101416"/>
    <dbReference type="KEGG" id="sco:SCO5974"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6072"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_0_11"/>
    <dbReference type="InParanoid" id="Q93JF3"/>
    <dbReference type="OMA" id="CAWATTA"/>
    <dbReference type="PhylomeDB" id="Q93JF3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="16"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC44588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="431" mass="43894" checksum="59FF6A51E8CA875F" modified="2001-12-01" version="1">MSPDALITHFVGASALILVAAHSGGWLARRLGQPYIVGQLATGIALGPSLLGSMAPDAYAALFPAAIGPALTGLAQFSLVVFLFAVGYELDLKMLGVRARSSVNVALASFAVPMAVGSGCALLFGDALHDLGMPGDLSPGMVVFAGVALATTAVPVLTAIVRENGLSRTVPGVVAVSAAGVLDAICWTVLAGALLEAGGGDGAGGGLGWPWRVLLTVGYVALMACAARPLLRLLLWRTRLEPSLRMALLIGFALGSAWVTHALGLHVIFGALLAGVVVPREAGGTLDPDLLRPLLSVASLLLPFFFVLSGQSVALNSMTGTGWAALAVVTLLAVVTKIGSGAAAAGLGGLDRHDAWTVGILLNTRGLTELIALNAGLDAGLLSAPLYTVLVFMALATTLLTQPLLLLNARLATRERRPESARSTAVKPYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RT6</accession>
    <name>Q93RT6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630402.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030812.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6305"/>
    <dbReference type="GeneID" id="1101746"/>
    <dbReference type="KEGG" id="sco:SCO6305"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6419"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_1_2_11"/>
    <dbReference type="InParanoid" id="Q93RT6"/>
    <dbReference type="OMA" id="TTNYKAI"/>
    <dbReference type="PhylomeDB" id="Q93RT6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC37526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="347" mass="37355" checksum="0A4648EDDA84A06B" modified="2001-12-01" version="1">MPTPAVPTPAANAPAVHTPTVDVHAHVLLPEVEALVAGLPGHAGAREMDARRIGPAALAVNGPMVRDRVPRMTDVALRLAAMDTQGVDVQLVSPSPSHYHYWTDEDTAEKLYRLANEAVAAHCSAAPERLRGLGLVPLQHPEQAVRALDHALEQGLAGVEISSHAPDRELSDPAYESFWTRAGETGAIIFLHPFGCTLDERLDQWYLSNTVGQPTENAVALSHLIFSGVLDRHPRLRLIAAHGGGYLPTHIGRSDHAWSARSDAGAGCAHPPSSYLKRLYFDSLVHDRHVLRELIRAAGADRVLLGSDFPFDMGTEDPVGALRAARLTDSDFHAVRGGNAAALLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q99PZ8</accession>
    <name>Q99PZ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.11c</name>
        <name evidence="3" type="ordered locus">SCP1.343</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639587.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639951.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039313.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095090"/>
    <dbReference type="GeneID" id="1095425"/>
    <dbReference type="KEGG" id="sco:SCP1.11c"/>
    <dbReference type="KEGG" id="sco:SCP1.343"/>
    <dbReference type="HOGENOM" id="CLU_1123996_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="28067" checksum="E848A5CA8F91BB55" modified="2001-06-01" version="1">MIPSGFSLKGGVSPIRQHDRRERHAALEVAMRKPHDPHEQTLPAHLVAIVDAAIRRRAGKEPCAPDDLGIRDQRYARRPLDGSAGYHLWSPTHGLGFCNRHARRRGFLPYWRDEELGPPMAAVHVPPEQRCGGWVAPRYLPRPWIGPLPERWPEERIPIWYAWWRLHDIQDGTCATCSAPAYAIDHDHHTGLVRGLLCVSCNKREGTCRRRAQEGTHPGRPCFQPYWDDPPAAPLRWMHGKSSLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QQ0</accession>
    <name>Q99QQ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.22c</name>
        <name evidence="2" type="ordered locus">SCP1.332</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639598.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639940.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039324.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095101"/>
    <dbReference type="GeneID" id="1095414"/>
    <dbReference type="KEGG" id="sco:SCP1.22c"/>
    <dbReference type="KEGG" id="sco:SCP1.332"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7968"/>
    <dbReference type="HOGENOM" id="CLU_2636370_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="8345" checksum="09E84C0E92B34F08" modified="2001-06-01" version="1">MADVTYRGYGVIGTGHWGNPLDRIVDLANLALKFGEATLRIRTEHDNGVTITFQTLKFSPAGVEAVEASSVLEPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACP2</accession>
    <name>Q9ACP2_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.277</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011039578.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095360"/>
    <dbReference type="KEGG" id="sco:SCP1.277"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8221"/>
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    <dbReference type="OMA" id="MIDPTWP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="71" mass="7545" checksum="FB71E0EE19FF6C12" modified="2001-06-01" version="1">MRPDGTVLDPTWDDAPGRAYVGIPIADSSLWPIDGGGLLDDFDRTLPLLRDGFSRHALADLGRPLTAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD54</accession>
    <name>Q9AD54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.96</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639669.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039395.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095174"/>
    <dbReference type="KEGG" id="sco:SCP1.96"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8044"/>
    <dbReference type="HOGENOM" id="CLU_191540_0_0_11"/>
    <dbReference type="OMA" id="DTGELMP"/>
    <dbReference type="PhylomeDB" id="Q9AD54"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8401" checksum="A6C919E706A6089A" modified="2001-06-01" version="1">MNRTTTTATGTRLPDSLCTHTPKCPTADSPDREAARTTASHPEQGWSLLCNGIFLFEDTGELLPDGRAVAPHRPVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJY0</accession>
    <name>Q9AJY0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7750</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631786.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971387.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7750"/>
    <dbReference type="GeneID" id="1103188"/>
    <dbReference type="KEGG" id="sco:SCO7750"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7872"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_4_11"/>
    <dbReference type="OMA" id="FTDLAFC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14290" checksum="ACC4C4D29BB2D501" modified="2001-06-01" version="1">MTTRPDHHLQPTTVDSQDSLRIEVRGDLDYASADLLVAEVTAGLSGQPALTDLHLSCAGLGAVDSMGLSALLMIGRRTTAAGVRLHLDDRPANLNRLLELTGTLEHLTAPSPVGAEETPGTGDSTVKARPTGQDANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF8</accession>
    <name>Q9EWF8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4957</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629109.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974019.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4957"/>
    <dbReference type="GeneID" id="1100398"/>
    <dbReference type="KEGG" id="sco:SCO4957"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5037"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064093_0_0_11"/>
    <dbReference type="OMA" id="WCEKWHG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="372" mass="40745" checksum="1073CE0306CE2752" modified="2001-03-01" version="1">MEILWVLMALVMLGFVLLQVSRRRRGAVGLVEPGHPDAADPANYGFAREEELDIRMPGPDQDLLDVLDLVQRTQDYRGAMQLLAGTEAEGERRWQRVQAFAGAASLELRQRPGGVGETPGGQWLRVWRAEAPKDAGGAAVHAEFLVQQAWRTSTPGSDDFRIIMEEARAACGEAALLAPGDPVPYIVELSVARGLGYSREEFEQLWLKILDRAPNHMGAHLAALQYWCEKWHGSRQLAYSFAEAAAARAPRGSLLAAMPLFAVFEHLPEVNLVSGFYQSEVVTKAVHGALHAVHSARPDDPMQAHVRHLLVFFLVRGERWAEAMNQLTVIDGHVGALPWTLSTDPAAEFAVYRALAVAGYEANGGSPATLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2U5</accession>
    <name>Q9F2U5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4617</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628779.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029766.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4617"/>
    <dbReference type="GeneID" id="1100057"/>
    <dbReference type="KEGG" id="sco:SCO4617"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4690"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025569_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2U5"/>
    <dbReference type="OMA" id="MRLCNFA"/>
    <dbReference type="PhylomeDB" id="Q9F2U5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="490" mass="53789" checksum="46BCD7DAC178FBAB" modified="2001-03-01" version="1">MSEDEKTPAREIITDYAQAHFRYFRTADGTVYAQRNGHPVARPIRSQGTTGSHRQELMVGLFKDGIGVFNGTAMKEALDLIEALALTEDVQPVHIRVAPGFDGATWLDLGRDDGRSVRIHPTGWDIAIPDPREVCWRRTQLTGELPVPIKDTDGKGIDLLLRLCNFATAETECLAIAWLIGCLGPSVPVPAPFLTGPQGAGKSTGGRMLVRIIEGMTGDLRRAPKDEENLIAAVAAGWVTALDNLSHMTPDLSDAMCCIVTGAENVKRALFTDGDVFRARYRRPLLLTGIDVGVIRPDLAERLLPLRLERPKVRRTEAELWTEYAEVLPVVLGSLLDLAVKVRAVEVETPTDLRMADFAHLCAQLDAATGFGALAAYRAALDDLNDDVIEGDLLAQTVLRHAADLEPGTTQRMTSTEWLHCLSQLYTGEEFRPLPKGWPTTGKVLSDRLKRLQPTLAARGVLIDSGRTYEGRYLEMTRAPATPSPQQQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2W4</accession>
    <name>Q9F2W4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4597</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628759.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029752.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4597"/>
    <dbReference type="GeneID" id="1100037"/>
    <dbReference type="KEGG" id="sco:SCO4597"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4669"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="InParanoid" id="Q9F2W4"/>
    <dbReference type="OMA" id="LTYPLWF"/>
    <dbReference type="PhylomeDB" id="Q9F2W4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="46"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="262"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC08298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="455" mass="48838" checksum="BE77FCF0DC6452AA" modified="2001-03-01" version="1">MATEYGQGYGLGSGSGFPGHTGKRHHRLPAGLRAPFEARSWREFGYVLVGLPVGILLFTYAVTMVSLGAGLLVTFLGVPVLAAALAGCRGFGAMERARARALLGLRVSEPEPLRLKKQGAMGWMGAVLKSGASWRSLLYAVLQFPWSVFSFVVAVNVWAFGWAMLTYPLWFWVFPMYAGQDGLQLYGDETHRVYLDNPFEIAVTALVGLLFTLATPWLVRALTTVDRVMVHGLLGPSRLATRVVELESDRGVVVDTAAADLRRIERDLHDGAQARLVNLAMDLGLAKEKLKEDPRAAAVMVGEAHGEVKTALQELRDLARGIHPAVLTDRGLDAALSSVASRCTVPVRVEVDLAERPASAIEGIAYFTVSELLQNVSKHARATSAAVEVWRVENRLMLQVVDNGVGGADASAGSGLAGLAERLDAVDGILVVDSPAGGPTRITAELPWRNEPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3B2</accession>
    <name>Q9F3B2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter solute binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7563</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031748.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7563"/>
    <dbReference type="GeneID" id="1103001"/>
    <dbReference type="KEGG" id="sco:SCO7563"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7677"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_11"/>
    <dbReference type="InParanoid" id="Q9F3B2"/>
    <dbReference type="OMA" id="TYYGRFV"/>
    <dbReference type="PhylomeDB" id="Q9F3B2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004326293" evidence="1">
        <location>
            <begin position="38"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="85"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="516" mass="55840" checksum="7B880CB9D988D126" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3F0</accession>
    <name>Q9F3F0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7607</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631648.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031777.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F3F0"/>
    <dbReference type="STRING" id="100226.SCO7607"/>
    <dbReference type="GeneID" id="1103045"/>
    <dbReference type="KEGG" id="sco:SCO7607"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7724"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_3_11"/>
    <dbReference type="InParanoid" id="Q9F3F0"/>
    <dbReference type="OMA" id="ENVHRAG"/>
    <dbReference type="PhylomeDB" id="Q9F3F0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="393" mass="42234" checksum="A54AA5D1B3F122D2" modified="2001-03-01" version="1">MHNGFKSMPRSRRRTGERTPAVSDALDPEVLDAAVENVHRAGMPGLFAEVRDGDQVWRGAAGVADVDTGRPVTADLRHRVGSITKTFTAAAVLQQVEQGRIVLDAPIGRYLPGLLPDGRGEAVTVRMLMNHTSGLAEYLPHAYSSLKAFPALADTGPQSLDDHRFTRFDPAELIALGVAAPAVGPPGGAPGLYSNTNYLLLGKLLEEVTGTSAERCITRNVIERAGLRDTELPTGPYVGEPHSRLYESWFGMIDPPRDYSVYDMSWVGPSASLISTVSDLNRFFGMLLAGEIVSPSSLAQMRRTVPVVSQEGRTIEYGLGLHPTQAPGQDTFWGHGGTAWGAGALAVISADGRRRVAVAVNLQRWNALDSAGRPRPHPIDDALAAFHRVAMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC05</accession>
    <name>Q9FC05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7177</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631235.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7177"/>
    <dbReference type="GeneID" id="1102615"/>
    <dbReference type="KEGG" id="sco:SCO7177"/>
    <dbReference type="eggNOG" id="COG1378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288258_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="23260" checksum="6C6B960625502418" modified="2001-03-01" version="1">MAEADAPMALVGLDADTEAVYRELLTRGGGTADSLVTAFGLNRSQAVAQLDRLHRSGLLSRRSSGEYQTVDPRHALAALVESRTRQLAAVRDAASSLGELFDEARRSGTPQPDTRTISGAEEVGDCYYRLKQAARREICELHARPTCWLPTSRWTRPQSAAGCGYGPSTPPPASTTTVAGRTSAAWSPVARRPEWCPRCPSSSSWSTARWPWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCC5</accession>
    <name>Q9FCC5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1242</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977589.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1242"/>
    <dbReference type="GeneID" id="1096665"/>
    <dbReference type="KEGG" id="sco:SCO1242"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1241"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="WHQSKVS"/>
    <dbReference type="PhylomeDB" id="Q9FCC5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="286" mass="30970" checksum="0006579AD1B1EEE8" modified="2001-03-01" version="1">MQHGPVVRRRKLGAELRALRTSAGITSGEAARLVGWHQSKVSRIETGTSGAKPADVRLLLDAYGVTDEQLRGLLVMLAHSEDAGGRNHWWHAYRGVLPPTYRDFISLESQAAAMRTLETTVVPGLLQTPEYARAVTRAAVDGMPAERLDTLVEVRLARQDVLRGEPPLELSAVLDEAVLRRVVGGPGVMSRQLTRLVEAAQLPHVRIQVLPFAAGAHIGVTGPFVIFSFSSTSDLDVVVLDHLTSSLHLERKEDLEAYTEAFNALLIHALSPEDSLDFIAATAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Q4</accession>
    <name>Q9K3Q4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1094</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625388.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977736.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1094"/>
    <dbReference type="GeneID" id="1096517"/>
    <dbReference type="KEGG" id="sco:SCO1094"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1091"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_0_11"/>
    <dbReference type="InParanoid" id="Q9K3Q4"/>
    <dbReference type="OMA" id="KGCFTIA"/>
    <dbReference type="PhylomeDB" id="Q9K3Q4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB95981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="20941" checksum="54AEFDA6FF959E74" modified="2000-10-01" version="1">MARTREFDTEAAVSRAMELFWTRGYEATSVRDLTGHLGIGQGSLYAAFGDKDGLYRAALEHYRTTLAAAALRSLEEGTDARSAIRTMLVERIRIAVDDNGRGCLAVNAACERLPEDAATRRTVRDMQDAGRDALTEVLRVAAERGEIAKRHDPHTLAAFLVTFLNGLLVSSKITPDVRALEPLVEVALAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Q6</accession>
    <name>Q9K3Q6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1092</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625386.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977738.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1092"/>
    <dbReference type="GeneID" id="1096515"/>
    <dbReference type="KEGG" id="sco:SCO1092"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1089"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160046_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3Q6"/>
    <dbReference type="OMA" id="EMWIADP"/>
    <dbReference type="PhylomeDB" id="Q9K3Q6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="14307" checksum="A1916A56D17EECC5" modified="2000-10-01" version="1">MVHVLSSRTLLRPTDPDRSRAFYGEQLGLAVHREFGTGPERGTVYFLGNGFLEVSGRSDTPLTPGLALWIQVEDAAAAHEELGAKGVEIVRPPVKEPWGLVEMWIADPDGTRIVLVEVPAEHPLRYRPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3R1</accession>
    <name>Q9K3R1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1087</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625381.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027566.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9K3R1"/>
    <dbReference type="STRING" id="100226.SCO1087"/>
    <dbReference type="GeneID" id="1096510"/>
    <dbReference type="KEGG" id="sco:SCO1087"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1084"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049619_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3R1"/>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="PhylomeDB" id="Q9K3R1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB95974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="356" mass="39108" checksum="9BC43F91B4ACAFF2" modified="2000-10-01" version="1">MNPPKTDARRHHDPEVRGFASDNYAGAHPEVLAALALANGGHQVAYGEDDYTENLQRVIRSHFGSGAEAFPVFNGTGANVVALQAVTDRWGAVICAESAHINVDEGGAPERMGGLKLLTVPTPDGKLTPELIDRQAYGWDDEHRAMPQVVSITQSTELGTLYTPDEIRAVCEHAHAHGMKVHLDGSRIANAAASLDVPMRTFTNAVGVDLLSLGGTKNGALFGEAVVVLNQDAVRHMKHLRKLSMQLASKMRFVSVQLEALLAKDLWLRNARHSNEMAQRLAEGVRAVHGVEILYPVQANAVFARLPHEVSERLQKRFRFYFWDEAAGDVRWMCAFDTTENDVDAFVSALKEEMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3W5</accession>
    <name>Q9K3W5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="558" mass="59043" checksum="452894F38682AE6A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
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        <name evidence="3" type="ordered locus">SCO1353</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB95810.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1353"/>
    <dbReference type="GeneID" id="1096776"/>
    <dbReference type="KEGG" id="sco:SCO1353"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1361"/>
    <dbReference type="eggNOG" id="COG2197">
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    <dbReference type="HOGENOM" id="CLU_056943_1_0_11"/>
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    <dbReference type="OMA" id="TRFQAGM"/>
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    <dbReference type="Proteomes" id="UP000001973">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    </dbReference>
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        <location>
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            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="36356" checksum="F18ABCEAD31AD499" modified="2000-10-01" version="1">MAPIGHHGTGRADNRLMANEKLGESLRVLGLDPTACRVYLALLELSPAPLEAIGAATGLSGARLAAAYATLADTGLASAAAGGADVVAPVPPAAGLEVLARHRAAELEESRIAVGGAFESFRRRRLAAYNDGLVEVVTGEDVGPRMRHAWASAREQIRQFESPPYVHLAGATDDALATLARGVTQRVVYARESLERPGQLENVIEPCIEAGEQARVLPSVPVKLLIIDEAFALVSLSIKDADVHNTMLVVQPCGLLSALAALFEQTWRDAVPLHGPAARPAGLPAADRRLLRLLAGGATDEAAARELGISRRTLFRRLQILMARLGAANRFQLALQAQRAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXI6</accession>
    <name>Q9KXI6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626581.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028289.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2334"/>
    <dbReference type="GeneID" id="1097768"/>
    <dbReference type="KEGG" id="sco:SCO2334"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2371"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017262_1_0_11"/>
    <dbReference type="OMA" id="GWNRQLD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
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            <end position="229"/>
        </location>
    </feature>
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            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="551" mass="59486" checksum="6DF4A5BE234D8E9E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXN2</accession>
    <name>Q9KXN2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAB93399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974650.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4325"/>
    <dbReference type="GeneID" id="1099765"/>
    <dbReference type="KEGG" id="sco:SCO4325"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4394"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125944_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXN2"/>
    <dbReference type="OMA" id="QRVEFGM"/>
    <dbReference type="PhylomeDB" id="Q9KXN2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001072">
        <property type="term" value="F:transcription antitermination factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13558" checksum="EFB573D9E305F393" modified="2000-10-01" version="1">MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPAGVESLKPGQRVEFGVVAGQRGDQALSLALLDPAPSVAAAQRKKPDELASIVQDLTTLLENITPMLERGRYPEKTAGKKIAGLLRAVADQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXT3</accession>
    <name>Q9KXT3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4308</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628480.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974666.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4308"/>
    <dbReference type="GeneID" id="1099748"/>
    <dbReference type="KEGG" id="sco:SCO4308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4376"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KXT3"/>
    <dbReference type="OMA" id="VPFIHRS"/>
    <dbReference type="PhylomeDB" id="Q9KXT3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="150"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="32563" checksum="972A2BF68FE74706" modified="2000-10-01" version="1">MNASGGRRATGGGSAPPAPPAPPAPAALAAKVRTLGPSMTRSMQRVAEAVAGDPAGCAALTVTGLAELTGTSEATVVRTARLLGYPGYRDLRLALAGLAAQQQSGRAPAITTDIAVDDPIADVVAKLAYDEQQTLADTAAGLDTVQLGAAVAALTAARRTDVYGIGASNLVAQDLTQKMLRIGLIAHAPGDPHLAVTNAVQLRAGDVALAITHSGSTGDVIEPLRVAFERGATTIAITGRPDSPVTQYADHVLTTSTARESELRPAAMSSRTSQLLVVDCLFVGVAQRTYESAAPALAASYEALAHRHGALRGVAGDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXY8</accession>
    <name>Q9KXY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative secreted arabinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2427</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626671.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976379.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2427"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="GeneID" id="1097861"/>
    <dbReference type="KEGG" id="sco:SCO2427"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2468"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_5_1_11"/>
    <dbReference type="InParanoid" id="Q9KXY8"/>
    <dbReference type="OMA" id="GHLWAPD"/>
    <dbReference type="PhylomeDB" id="Q9KXY8"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176749" evidence="7">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR026534-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR026534-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB92901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="34237" checksum="3943074A5FCD98D9" modified="2000-10-01" version="1">MRRRRAALLALPTAALLALVPSTASAYPNPGRVTGSVVTHDPTMIRTSSGQYRLYATGGGISSKASSDRTAFSAGADAFGSRPGWWSRYSSVPEAWAPDISYHGGKYLMYYSVSSFGSNTSAIGLAGSTTGAPGSWSDYGIVYTSGSASDYNAIDPNLFVDDDGTWWLSFGSWWTGIKMIRIDPATGKQLASDTARRSLASRPTGTKAVEAPYVVKRNGYYYLFASYDTCCAGTGSTYKVKVGRATSVTGPYRDRNGVAMTDNGGTPVLESHGSVIGPGGQSIMNDVDGDLIVYHYYDGNDNGTPKLGINLLDWSSGWPVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYG9</accession>
    <name>Q9KYG9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2703</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626937.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976097.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2703"/>
    <dbReference type="GeneID" id="1098137"/>
    <dbReference type="KEGG" id="sco:SCO2703"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2758"/>
    <dbReference type="eggNOG" id="ENOG5031PCZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178596_0_0_11"/>
    <dbReference type="OMA" id="EPIDVMP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176768" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="100" mass="9870" checksum="0D770ED1D46F938A" modified="2000-10-01" version="1">MKSLKAAAVVAGSLVAAGSAVPAFAYDASDAAALTPTSLNGAVNALTAEPIDVMPIKHQSEARSDALDTENKDSVLHTVKGATTKLNSAKGLLGGLPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI2</accession>
    <name>Q9KYI2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2690</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626924.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028516.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2690"/>
    <dbReference type="TCDB" id="2.A.1.2.89">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="GeneID" id="1098124"/>
    <dbReference type="KEGG" id="sco:SCO2690"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2746"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_5_11"/>
    <dbReference type="InParanoid" id="Q9KYI2"/>
    <dbReference type="PhylomeDB" id="Q9KYI2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="11"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB92256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="454" mass="47695" checksum="AD3AFA5AA039019A" modified="2000-10-01" version="1">MISLGLPRIPQRGRIFSSVFIDTFGWGLFAPLAFLYFSYNTGLSFSAIGSAVSAGTLATLPTALLAGWLVDRFSPKAVLVSSNLVTALGYGLYPFASEWTLIAVATFLVMAGDRLYWASWPVIVVDLASGRKLDATYAAVGTIKNFTVATGALASSGLTVVLGHGAADLVLALNVVTSLVAAVLLAGVRIPATRPGPEPGATEEEQENPGRPAPGWRDAFTDHAFTGFCFFFMLLTFAWALPSTILPAYSVEIMELPDWTPALFLGINSVAIMLAQMPVTARVSHVPRQRLIVRSGLIFVVVFTGLYLVTKVPATTAIVVLVPVMLTFTLGEMISLPAANALVASSAPAAIRGRYMSLFQLSWAVSGLFIPLLAGFVLDRGALWVCAAFGGIALLAAIGIQATAYRIAPADRPGPTPRGAKTGAPGPDHPSDQAASLDPGPSESTRPVSTKDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYQ4</accession>
    <name>Q9KYQ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3666</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB91157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975273.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3666"/>
    <dbReference type="GeneID" id="1099102"/>
    <dbReference type="KEGG" id="sco:SCO3666"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3724"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056943_0_1_11"/>
    <dbReference type="OMA" id="ISVRTCR"/>
    <dbReference type="PhylomeDB" id="Q9KYQ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB91157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="394" mass="42899" checksum="00EAD4D38348B8B7" modified="2000-10-01" version="1">MSARFHGDRAFRPQPALFGLRPPRSLVAEPVPAAHSCAAEEPEPGVGWAMAGHGAQEHPHGADRLCAAGDRVYSRAVRRGRVPRRDAEPVPCLLELALLHPDPDDMDWLVPTSPQEVMTRLLRGVHDEVSASQRRVGSAVEAFEWYADLGRLLQTPAGTESTAIRVLDGLSRIQAAMDEATQACTTEVLTVQPGGIRREHELSEGLHRALALRGRGVRMRDLYTHVARHGQGLLNYLELMGDAVEARTLDEVIDRLILFDRTVAFIPANTDRTMALELRHPALISYLVTVFERLWRLAIPLTAPLPDTGIEGISHREQSIAALLAEGHQDAVIAERLGISVRTARAHIARLSETLGAASRTQLGVRIAQAGLDGSPRGAPSPVMLPGRESPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYV3</accession>
    <name>Q9KYV3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3192</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627406.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3192"/>
    <dbReference type="GeneID" id="1098626"/>
    <dbReference type="KEGG" id="sco:SCO3192"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3252"/>
    <dbReference type="eggNOG" id="COG4292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045667_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYV3"/>
    <dbReference type="OMA" id="HMAERCA"/>
    <dbReference type="PhylomeDB" id="Q9KYV3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329870" evidence="3">
        <location>
            <begin position="40"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB90976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="440" mass="47054" checksum="A5DBF6FBCA716692" modified="2000-10-01" version="1">MDDVPCAPPAPAKRGARKHVRAPSAVLGAMMSSPSSASAPSGPPPDGHPPVRRLKARHRHESHRAATPLELFFDLCFVVAIAQAGVQLVHAVAEGHAGEGVLNYAMVFFAIWWAWMNFTWFASAYDNDDVLYRVVTLVQIAGVLVLAAGVSRAFEDHDWVAVVIGYLIMRVAMAAQWLRAGRSAAPPESTMARSYSVGVLLCQIGWLGILFLPEDDRGWLFLVMVVLELCVPAYAERKHPSSWHPHHIAERYGLLTIIVLGETIAAATVAVKSGIEENDALGEVLPIAAGGLLIVFAAWWIYFVVPVHSYLRSSRQSFLWGYGHYLVFASAAAIGAGLEVTVEQAVGKAHISAVAAAAAVTLPTAVFLLTVWALHARHFKVGIAEQLVLPTAALLVLGCTFLGAEAVLVAGIVLALTVAAGVALTARRTERERRAAAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYW2</accession>
    <name>Q9KYW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3019</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627241.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028719.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3019"/>
    <dbReference type="GeneID" id="1098452"/>
    <dbReference type="KEGG" id="sco:SCO3019"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3079"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048408_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYW2"/>
    <dbReference type="OMA" id="RVMKMPF"/>
    <dbReference type="PhylomeDB" id="Q9KYW2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="192"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="436" mass="47146" checksum="26550C9B8C94321E" modified="2000-10-01" version="1">MALTGRAALIAALASVPVGIWDPSWTGILAVNAPLAAACACDFALAAPVRRLGLTRSGDTSARLGDTADVTLTVTNPSGRPLRARLRDAWPPSSWQPGTETAASRHSLTVPASERRRVTTRLRPTRRGDRQADRVTIRSYGPLGLLTRQGTHRVPWTVRVLPPFTSRKHLPSKLSRLRELDGRTSVLTRGEGTEFDSLREYVPGDDTRSIDWRATARHSTVAVRTWRPERDRHILLVLDTGRTSAGRVGDAPRLDASMDAALLLAALASRAGDRVDLLAYDRRVRALLQGRTAGDLLPSLVNAMASLEPELVETDARGLTATALRSTPRRSLIVLFTTLDAAPIEEGLLPVLPQLTQRHTVLVASVADPHISAMAEARGHTDAVYEAAAAAQAQSERRHIADQLRRHGVTVVDATPDELPPALADAYLELKAAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYZ3</accession>
    <name>Q9KYZ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO7536</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631580.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031731.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7536"/>
    <dbReference type="GeneID" id="1102974"/>
    <dbReference type="KEGG" id="sco:SCO7536"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7650"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KYZ3"/>
    <dbReference type="OMA" id="AWWIPAW"/>
    <dbReference type="PhylomeDB" id="Q9KYZ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176780" evidence="8">
        <location>
            <begin position="37"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB90894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="739" mass="76120" checksum="93F4E980D502A4B7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ53</accession>
    <name>Q9KZ53_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative insertion element transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7078</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631140.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031419.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7078"/>
    <dbReference type="GeneID" id="1102516"/>
    <dbReference type="KEGG" id="sco:SCO7078"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_4_2_11"/>
    <dbReference type="InParanoid" id="Q9KZ53"/>
    <dbReference type="OMA" id="DEIDWIR"/>
    <dbReference type="PhylomeDB" id="Q9KZ53"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15832" checksum="56B1B7F83E48A58D" modified="2000-10-01" version="1" fragment="single">SWIVPDGLWETAKPLIPPSKVRPRGGGTQDTPDETLFAAIIYVLVSGCAWHALPPCFGTSKSTAHRRFLIWSRAGVRGRLHEAVLHRLDDAGLIDVTRAVLDTAHVRARRGANTQVRAPWTTSPPPAPGEGLWWWPSRGRAGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZB2</accession>
    <name>Q9KZB2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4834</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628989.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029896.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4834"/>
    <dbReference type="GeneID" id="1100275"/>
    <dbReference type="KEGG" id="sco:SCO4834"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4910"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_11"/>
    <dbReference type="InParanoid" id="Q9KZB2"/>
    <dbReference type="OMA" id="ITVINGW"/>
    <dbReference type="PhylomeDB" id="Q9KZB2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="16058" checksum="65EB3D9D08E85D24" modified="2000-10-01" version="1">MTARTQLLDREVGKALSALSAAAKKGLGDPVLAELVMIRASQLNHCAFCLDMHLALARKNGEGEERLGLLAAWEEAADLYDGRERAALALTEAMTVLTEGFVPDEVYEEAAVHFDDGELAHLIGLITVINSWNRLMVSRRVPPGGYTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L012</accession>
    <name>GCH1L_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2301</name>
        <name type="ORF">SCC30.09c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626549.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028263.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L012"/>
    <dbReference type="SMR" id="Q9L012"/>
    <dbReference type="STRING" id="100226.SCO2301"/>
    <dbReference type="GeneID" id="1097735"/>
    <dbReference type="KEGG" id="sco:SCO2301"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2338"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L012"/>
    <dbReference type="OMA" id="ISMHTNF"/>
    <dbReference type="PhylomeDB" id="Q9L012"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000147335" description="GTP cyclohydrolase 1 type 2 homolog">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AFP6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="285" mass="30203" checksum="EA2CB7DE9E1DA3E6" modified="2000-10-01" version="1">MPRLSEVITALDALWPAERAESWDAVGTVVGEPDQEVSRVLFAVDPVQETVDEAVGLGADLLVTHHPLYLRGTTTVAASTFKGRVVHTLIKNDIALHVAHTNADTADPGVSDALAGALDLNVVRPLVPDPSDPEGRRGLGRVCELTHPLTVRELAARAAERLPATAQGIRVAGDPEATVRTVAVSGGSGDSLFDHVRAAGVDAFLTADLRHHPVSEARAHNPLALLDAAHWATEWPWCELGAAQLDEISDRHGWDLRVHVSKTVTDPWTAHVASAPTSSAMGAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L072</accession>
    <name>Q9L072_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2782</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627012.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028583.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L072"/>
    <dbReference type="STRING" id="100226.SCO2782"/>
    <dbReference type="GeneID" id="1098216"/>
    <dbReference type="KEGG" id="sco:SCO2782"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2839"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_11"/>
    <dbReference type="InParanoid" id="Q9L072"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="PhylomeDB" id="Q9L072"/>
    <dbReference type="BioCyc" id="MetaCyc:SCO2782-MON"/>
    <dbReference type="BRENDA" id="4.1.1.18">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="480" mass="52321" checksum="F43C9787D15095EC" modified="2000-10-01" version="1">MRSHLLNDTTAEQYRRSVTEGVERVAAKLATTDRPFTGVTVDALSPRIDAIDLDEPLHDTAAVLDELEDVYLRDAVYFHHPRYLAHLNCPVVIPALLGEAVLSAVNSSLDTWDQSAGGTLIERKLIDWTCARIGLGPAADGVFTSGGTQSNLQALLLAREEAKAEDFADLRIFASEASHFSVRKSAKLLGLGPDAVVSIPVDRDKRMQTVALARELERCARDGLVPMAVVATGGTTDFGSIDPLPEIAGLCEQYGVWMHVDAAYGCGLLASLKYRDRITGIERADSVTVDYHKSFFQPVSSSAVLVRDAATLRHATYHAEYLNPRRMVQERIPNQVDKSLQTTRRFDALKLWMTLRVMGADGIGVLFDEVCDLAAEGWKLLAADPRFDVVVQPSLSTLVFRHIPADVTDPAEIDRANLYARKALFASGDAVVAGTKVAGRHYLKFTLLNPETTPADIAAVLDLIAGHAEQYLGDSLDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0F9</accession>
    <name>Q9L0F9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4683</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628842.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029813.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4683"/>
    <dbReference type="GeneID" id="1100124"/>
    <dbReference type="KEGG" id="sco:SCO4683"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4755"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0F9"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="PhylomeDB" id="Q9L0F9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="218"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB82051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="461" mass="49482" checksum="BC97D997DE83DB1F" modified="2000-10-01" version="1">MPAVPERAPVTTRSETQSTLDHLLTEIELRNPAQPEFHQAAHEVLETLAPVVAARPEYAEPGLIERLVEPERQVMFRVPWQDDQGRVRVNRGFRVEFNSALGPYKGGLRFHPSVNLGVIKFLGFEQIFKNALTGLGIGGGKGGSDFDPHGRSDAEVMRFCQSFMTELYRHIGEHTDVPAGDIGVGGREIGYLFGQYRRITNRWESGVLTGKGQGWGGSLIRPEATGYGNVLFAAAMLRERGEDLEGQTAVVSGSGNVAIYTIEKLTALGANAVTCSDSSGYVVDEKGIDLDLLKQIKEVERGRVDAYAERRGASARFVPGGSVWDVPADLALPSATQNELDENAAATLVRNGVKAVSEGANMPTTPEAVHLLQKAGVAFGPGKAANAGGVAVSALEMAQNHARTSWTAARVEEELADIMTSIHTTCHETAERYDAPGDYVTGANIAGFERVADAMLAQGVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Z5</accession>
    <name>RPE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpe</name>
        <name type="ordered locus">SCO1464</name>
        <name type="ORF">SCL6.21c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625745.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977361.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0Z5"/>
    <dbReference type="SMR" id="Q9L0Z5"/>
    <dbReference type="STRING" id="100226.SCO1464"/>
    <dbReference type="GeneID" id="1096890"/>
    <dbReference type="KEGG" id="sco:SCO1464"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1473"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0Z5"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="PhylomeDB" id="Q9L0Z5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044262">
        <property type="term" value="P:cellular carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000171581" description="Ribulose-phosphate 3-epimerase">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <sequence length="228" mass="24309" checksum="18DA0CBEF85350C4" modified="2000-10-01" version="1">MAAQINPSILSADFARLADEAKAVEGADWLHVDVMDNHFVPNLTLGVPVVESLARATDTPLDCHLMIEAPDRWAPQYVEAGAGSVTFHAEAAAAPVRLAREIRAKGARASMALKPATPVEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELIKKHGLELWLQVDGGVSAATIERCADAGADVFVAGSAVYGASDPAEAVRALRTQADAATAEASWSCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L162</accession>
    <name>Q9L162_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7453</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631501.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971689.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7453"/>
    <dbReference type="GeneID" id="1102891"/>
    <dbReference type="KEGG" id="sco:SCO7453"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7564"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778245_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L162"/>
    <dbReference type="OMA" id="VWGIAQE"/>
    <dbReference type="PhylomeDB" id="Q9L162"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176814" evidence="1">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="55"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="356" mass="36624" checksum="0DB8A8FBADC311B0" modified="2000-10-01" version="1">MKKCHVVYLVCTAAMIGTGLGAAPASSVPRTHLVHPGESIQKAVDAAEPGDTVLVTTGTYRESVKVSTPRLTLRGMGRSTVIRPSTQKAAANTCAEGGNGICAIGTKDENVKGITVSDLTVTGFTRTGVFSMATDGLTVRNVNAVKNGVWGIAQERSVHGVFRGNTARDNGDAGIFLANNIKAEEGAADTEGTLVAHNRLEGNRIGVTVRRLRNLAVAGNHITGNCAGVFVVGDENTPKAGDLVVRDNRVLRNNKSCPKTDRLEALQGSGIVLTGVEKVLVADNTVEGNSGKSSMSGGIVLASSMVGTANAKNEVNGNRLSRNSPADLVNAGTGDTGRSNTFTGNTCGASKPAGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L192</accession>
    <name>Q9L192_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7383</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631435.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971759.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102821"/>
    <dbReference type="KEGG" id="sco:SCO7383"/>
    <dbReference type="eggNOG" id="ENOG5032CCN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980249_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13709" checksum="8B36C736317306BD" modified="2000-10-01" version="1">MDGASHGHPCRAGWLIVCSPAGVRPPRAAEVAVTRMDPERYWSRPNRCLLECVSGVQAGRPIMYEMCVGPEKAGGALVWHVLSKQAAATLCGQQLRERIEASDGERARHCPDCMASFEKLMATTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1D6</accession>
    <name>Q9L1D6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1546</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625824.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977279.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1546"/>
    <dbReference type="GeneID" id="1096972"/>
    <dbReference type="KEGG" id="sco:SCO1546"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1557"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_4_0_11"/>
    <dbReference type="InParanoid" id="Q9L1D6"/>
    <dbReference type="OMA" id="VPWTRNE"/>
    <dbReference type="PhylomeDB" id="Q9L1D6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB76065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="273" mass="28976" checksum="966E2D0A1BBC9B28" modified="2000-10-01" version="1">MKIWLDGGLQDIGSARVSVLDHGLTVGDGIFETVKAVDGRPFALTRHLDRLTRSARGLGLPAPDHDEVRRACAAVLEANPMPLGRLRVTYTGGHGPLGSDRGEHGPTLVVALGETGRRPDSTAVITVPWTRNERGALTGLKTTSYAENVVALARARERGATEALFGNTVGRLCEGTGSNVFVVLDGEIHTPPVASGCLAGITRALAAEWTGARETDLPLDVLGRADEVFLTSTLRDVQAVHRIDDRELPGAPGPVTAKAMRIFQERSGDDLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1E2</accession>
    <name>Q9L1E2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629600.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030266.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5463"/>
    <dbReference type="GeneID" id="1100903"/>
    <dbReference type="KEGG" id="sco:SCO5463"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5547"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052806_1_0_11"/>
    <dbReference type="OMA" id="FTDRRVE"/>
    <dbReference type="PhylomeDB" id="Q9L1E2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="304" mass="32967" checksum="313B91B0B4090F10" modified="2000-10-01" version="1">MTDDGTGLMTIGELARTTGLTVRTIRYWSDEGALPPHARSAGGYRLYDAASVARLELIRTLRELGLGLDAVRRVLAGETTVAQVAAAHVSALDAQIAALRVTRAVLSTVARRGSTAEETTLMNKLARLSTTERRRIIEDFMAEVFAGIDTADPDIRTRLRFAAADLPDDPTAEQVDAWVELAELIQDPEFRVTMRRMIEFNAADRGPDVPAGSSLWFMSRLVRLAGDAVREGVAPDSPRAAGIVRTLIGDADPAVVLERLTAVANVRLARYRELSAIVNGLEPPSAHEDQFRWVVAALSARKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1P5</accession>
    <name>Q9L1P5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031255.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6870"/>
    <dbReference type="GeneID" id="1102309"/>
    <dbReference type="KEGG" id="sco:SCO6870"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6982"/>
    <dbReference type="eggNOG" id="ENOG5030UJS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121961_0_0_11"/>
    <dbReference type="OMA" id="WDTDPRT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="205" mass="21933" checksum="F7D32B3EA83E56AC" modified="2000-10-01" version="1">MPLIDPEKIPLSVRSFIARPTTGTGYCGIHVQLDGVPSHHLPLLLAAYQYRFGRDVEAMARHLIDDVTVGWDELGTDLLDGAPPALVTTLTGGEHWPSRTLDRLVTPDGSPPMRMTVTDATADAQDLQWGYVLHAEGIEVISILHADNGPLVDWAIDPRTAFNDHPAAWSPGPVPPRRGPRAAASANAPAAAPVKAGSPRSVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2B8</accession>
    <name>Q9L2B8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Asp-rich hydrophilic protein (Putative membrane protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5402</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629541.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030224.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5402"/>
    <dbReference type="GeneID" id="1100842"/>
    <dbReference type="KEGG" id="sco:SCO5402"/>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096493_0_0_11"/>
    <dbReference type="OMA" id="GTWHSVR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176837" evidence="2">
        <location>
            <begin position="24"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="3">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="26375" checksum="1C1F4061653A9607" modified="2000-10-01" version="1">MKRNIVIAAVTAAALIGGGTATALATTGDDDRGTASRADVADVADAPAVTVSDDGGVRDEADDRDDDRRDDDRRDDSRAAAAKVTAADAVAAALADTPGTAVSAELDDEDDDGDDGDDRRERAAWEVDVLAGDGTWHSVRVDPATGKVLGSERDDDEDDTAEVRAALKGASVDAAEAAKAAAGHGTVTSVELDDDGDHGDGRPAWEVETRASGEGGQDWRVDLKTGKVTADRSDEAHGSHDSDDADDSGSSDDTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="150" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2I4</accession>
    <name>Q9L2I4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transport ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2499</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626739.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028388.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2499"/>
    <dbReference type="GeneID" id="1097933"/>
    <dbReference type="KEGG" id="sco:SCO2499"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2544"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_0_1_11"/>
    <dbReference type="InParanoid" id="Q9L2I4"/>
    <dbReference type="OMA" id="PKAARYG"/>
    <dbReference type="PhylomeDB" id="Q9L2I4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cation_ATPase_C" evidence="8">
        <location>
            <begin position="1290"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1472" mass="151650" checksum="A71389768FE4D28A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-28" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2L4</accession>
    <name>YBEY_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">SCO2533</name>
        <name type="ORF">SCC117.06</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626772.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976270.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L2L4"/>
    <dbReference type="SMR" id="Q9L2L4"/>
    <dbReference type="STRING" id="100226.SCO2533"/>
    <dbReference type="GeneID" id="1097967"/>
    <dbReference type="KEGG" id="sco:SCO2533"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2578"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_2_11"/>
    <dbReference type="InParanoid" id="Q9L2L4"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="PhylomeDB" id="Q9L2L4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000102538" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="165" mass="18033" checksum="0F16529B74D89548" modified="2000-10-01" version="1">MSIDVNNESGTEVDEQAILDIARYALARMRIHPLSELSVIVVDAEAMEQLHIQWMDLPGPTDVMSFPMDELRPPSKDEEEAPQGLLGDIVLCPEVAAKQGAEAPTEHSMDEELQLLTVHGVLHLLGYDHEEPDEKAEMFGLQAAIVDGWRAEKGLTGPSPAPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCX5</accession>
    <name>Q9RCX5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0935</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625233.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027455.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0935"/>
    <dbReference type="GeneID" id="1096358"/>
    <dbReference type="KEGG" id="sco:SCO0935"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.930"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RCX5"/>
    <dbReference type="OMA" id="IVICWDY"/>
    <dbReference type="PhylomeDB" id="Q9RCX5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="23161" checksum="85DC6B90636C5FE1" modified="2000-05-01" version="1">MYDSELAEEEERRRKRAPWGVIALVLLTGLALIRNGSGEFDVGPPQPASAAASDTRSAVGDGAAAGVTPLPYSVPDQVSIPAIQVDAPVMGVGLDADGWVDAPPPEDPNLAGWFTGAVSPGEKGTAVVVGHVDNQQGPAVFYGLGALKKGNKVEVHRQDGKTAVFEIYGIEVFEKNNFPGDRVYGSKGSPELRVITCGGGFTKQNGYDGNVVAFARLVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDA6</accession>
    <name>Q9RDA6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GntR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627074.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028616.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2845"/>
    <dbReference type="GeneID" id="1098279"/>
    <dbReference type="KEGG" id="sco:SCO2845"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2904"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2119669_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="12633" checksum="681FED56A1015D1D" modified="2000-05-01" version="1">MPKQHAVKARIDRLVGELGEGSAIPTERDLSERHGVARETVRQALRELLPEGRLRRRERGTVVAGPKPAQPLSLVGRTEGVRRQGRTPGRALVTLDRFHCCADAQDHHPRPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY8</accession>
    <name>Q9RIY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein SCJ1.26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0177</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36959">
        <property type="entry name" value="T36959"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026904.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0177"/>
    <dbReference type="GeneID" id="1095601"/>
    <dbReference type="KEGG" id="sco:SCO0177"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.149"/>
    <dbReference type="eggNOG" id="ENOG50346AD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084215_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RIY8"/>
    <dbReference type="OMA" id="VWLWRWR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="193" mass="20752" checksum="8C91E04DF35CE8E0" modified="2000-05-01" version="1">MRAGTTIRRSLWRWRRNPLRRREDVLEAWILLIVWLVVALAGPVAGVLAAHASAHGAAQRRAERHSATATLVSDVSGSPLSTGTAGGRIEATVRWTAPDGTRHSGKIPVDEAMKAGSRVTVWTDHRNQLTTAPPTTAQAGVDAAFMGAASSFAVVTAAAAGYYGARVVLNRRRRAAWEHEWQDIGSQWGRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ65</accession>
    <name>Q9RJ65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1636</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625911.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027894.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1636"/>
    <dbReference type="GeneID" id="1097067"/>
    <dbReference type="KEGG" id="sco:SCO1636"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1651"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ65"/>
    <dbReference type="OMA" id="LPMCGTS"/>
    <dbReference type="PhylomeDB" id="Q9RJ65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="3">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="154"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="360" mass="39034" checksum="B34CF27A941BD200" modified="2000-05-01" version="1">MAGKPVRPVNAIDQTRRMLSLVTYLRERPGARVEDVARAFGITEDELVSDLDVLPMCGTSFRGGDLLDIDTDGERIWWHNPAALGADAAEPLRLAADEATALLVAARAVATLPGLRESDRQALLRATAKVEASAGEAAGASSRLSVTFESEGGVFADVDRAISERRRLWIRYYSPARDEVTEREIDPIRLVSVGHTYVEAWCRRSEARRTFRLDRVAEIRILDEPSAPPEVELRDLSEGLVQPAAEDPEVVVEVGPGGRWVAEYYPHDSADERPDGGLRITLRTPDPASLRRLALRLGRDGRIVSPPALADSARRAAREALAAYDGIEAAGAHGGVDTAEGARDGAAAAEGRHDRQEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJN0</accession>
    <name>Q9RJN0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0614</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624926.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978247.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096037"/>
    <dbReference type="KEGG" id="sco:SCO0614"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.595"/>
    <dbReference type="HOGENOM" id="CLU_159388_1_0_11"/>
    <dbReference type="OMA" id="RWLEQAY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="10118" checksum="BFB275963A514C04" modified="2000-05-01" version="1">MHPTTVPTAAAPTHSRSRDTGGDFLLQPPDPARRVPCRVDPVDLRRLDLLALLTAAGIAPSAGDRAAIEQLSVLPGSVHTALHRWLEQAYGFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ3</accession>
    <name>Q9RJQ3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0587</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624899.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027224.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0587"/>
    <dbReference type="GeneID" id="1096010"/>
    <dbReference type="KEGG" id="sco:SCO0587"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.568"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RJQ3"/>
    <dbReference type="OMA" id="GVRHSMT"/>
    <dbReference type="PhylomeDB" id="Q9RJQ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="15994" checksum="AC6ECD8440929C6D" modified="2000-05-01" version="1">MTATPGTTVPAPIMQTTDNSLTWLLQNLLDRTPGTRHALVLSRDGLRLCWTEHLTLDRADQLAAICSGIQALAQGASVEFGNGTGGVRHSMTEFHGGLLFIVEAGEGAHLAVVAVEDADPGVVGHQMTELVEQIGEHLRAEPRHAVPGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJS8</accession>
    <name>Q9RJS8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0408</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624729.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027093.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RJS8"/>
    <dbReference type="STRING" id="100226.SCO0408"/>
    <dbReference type="GeneID" id="1095831"/>
    <dbReference type="KEGG" id="sco:SCO0408"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.384"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RJS8"/>
    <dbReference type="OMA" id="QDEQVEC"/>
    <dbReference type="PhylomeDB" id="Q9RJS8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="28929" checksum="2938CECA3BFC3242" modified="2000-05-01" version="1">MLRQFASRRATWPTVTSSQLWTRETADRYDAEEAESGMGSAAVLGPTVDFLAELAGEGRALEFAIGTGRVGVPLRERGVPVAGIELSEHMAAVLRRKAAEETLPVTLGDMATTVVPGEFTLVYLVYNTITNLLTQDEQVECFRNAARHLGPGGRFVIELGVPPLRFLPPGQVAVPFDVSERHLGFDTFDLVEQILVSNHFTRDPGDGSYRRDNSRHRYAWPAELDLMARIAGLELERRVADWDGAPFTADSAKHISVWRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK92</accession>
    <name>Q9RK92_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0270</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624600.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026975.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0270"/>
    <dbReference type="GeneID" id="1095694"/>
    <dbReference type="KEGG" id="sco:SCO0270"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.244"/>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049438_0_1_11"/>
    <dbReference type="OMA" id="CHGWAGA"/>
    <dbReference type="PhylomeDB" id="Q9RK92"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04793">
        <property type="entry name" value="LanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033889">
        <property type="entry name" value="LanC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="466" mass="49047" checksum="567F8227E4261096" modified="2000-05-01" version="1">MSGTTEGGSPEHTMDGFSGSGTREAPAGESPRALRERAGAVSAEILDRLADPAATVAATRIPAQAADDGVAEPIWAELTLGSGSPGLALAFAGASRDAARQVPRAHAYLTAGTRAVSGRPGTAGGVFKGPGALAFAVLLAHRTTGGYVSALQRFDAYQRDLVRTVLPPVEDRPLPTIGHYEVVRGLTGVGRYLLARAESCEEPLTAVLDYLVRLSLGTVEHQGADVPRWWALDAPRIGSEAAFPGGHLNLGLSHGVAGPLALLALAWEQGVRVPRQREAMEATAALLRTWAVADRYGLFWPGYLSFAQWQRGPAAYDGTAKWPAWCYGAPGVSRALQLAGRALGRADFSDLARASVERLLVLPRPAWGIDDHALCHGWAGALHQLGRLNEGWQDSRLAELRDGIAADLVSAFDPELPFGLRFTMTKVPFGSDVSGYLDGAAGVALALDSYAAAGTPADWDMPLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKH5</accession>
    <name>Q9RKH5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627661.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028998.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3457"/>
    <dbReference type="GeneID" id="1098894"/>
    <dbReference type="KEGG" id="sco:SCO3457"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3517"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RKH5"/>
    <dbReference type="OMA" id="WANQNDI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="205" mass="21111" checksum="9CF9D64D638D67D7" modified="2000-05-01" version="1">MLDVRARAALSGPLDRAAAMLDRPAVTPNRLTALGLLTGLASAGSAAAGWWPAAAALWLLSRLADGLDGPLARRRGTANSSGAGGFLDISADFLVYGAFVVGVAVGVGGPALPFLLVLLTYYVNGTAFLAFSSIAERTGRRGDGRLSGGRSLNFLGGLAEGGETIAVHTLWCLLPGFAHTIAWVWAAVVAVTAAHRVVTGYRQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKK1</accession>
    <name>Q9RKK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4083</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628264.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029421.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4083"/>
    <dbReference type="GeneID" id="1099520"/>
    <dbReference type="KEGG" id="sco:SCO4083"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4142"/>
    <dbReference type="eggNOG" id="ENOG5030QNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626875_0_0_11"/>
    <dbReference type="OMA" id="CEIFSTE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="437" mass="46426" checksum="841C835FCA4BFAE4" modified="2000-05-01" version="1">MLDLSEAGGTITHRKLDDDSFDPDTEIPHDCEIFSTEAGERAGTDTGTRWFFTGAMGVLPADQPRIADAPMNGPLDILGRATYPPQPLGGDIAGRVTGSSVTVQLPCEEGTAEDKSVRALWARAEVMPRRGSQVSGHDRDILADTAVETANNLADRLGRAERLPNAPDHVPALTAGPVPAARAEGTCAWYGKTGLADRSPYPDEVVESRTDGRVWDESCGLVLSLGHANRVYEKLADAHDWLPTPDMPGEWFVSLHTYTGPVAENLRLTSADDGETPEPAVPGKAGRGATDPIWWASSVCDGRPQVHTMTLGHPGYAKLVASRMEDVFRAYVDDVTTRRHCTDVVRPGHATFRADWGESQRADWGESGGTDWLGSPPCRPPGNAPAPTTPPAPVPPSSPSSATYGRPSAPSPPSSSACRPGSGAGPCGSWSRTSGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL33</accession>
    <name>Q9RL33_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0454</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624774.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978412.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0454"/>
    <dbReference type="GeneID" id="1095877"/>
    <dbReference type="KEGG" id="sco:SCO0454"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.432"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="OMA" id="MLQFLWT"/>
    <dbReference type="PhylomeDB" id="Q9RL33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB56684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="33365" checksum="2AE7FAEDF5AC56B0" modified="2000-05-01" version="1">MTTLTTTPDGSAARRSVPPPSPAPAAGRRRQGGTVLAVPALVWYLVFMVGPLLAIFVIAALHWPGMLQPVSFAGLDNARVVLDDPVFWDAVRNTAVQLAVAVPVMIVCAFMLGYYVAQRPPGHRVIRYLLFIPGLISTPAKAMVFYAALSPDGLLNGGLESVGLGSLADAWLASPSTALACLIALDIWAGIGFTAVLFAARLGSVPDELGEAAQLDGAGHWRTMWSVHFPVIRDYVGVVTMLQFLWTLFGSAQHVLLLTQGGPGTSSTTLSFLVYQKAFIAADLGYSQTVGVLLFLAGLVGLLTIRRVFRQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1P5</accession>
    <name>Q9S1P5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO0246</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37161">
        <property type="entry name" value="T37161"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624578.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026955.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0246"/>
    <dbReference type="GeneID" id="1095670"/>
    <dbReference type="KEGG" id="sco:SCO0246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.218"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="InParanoid" id="Q9S1P5"/>
    <dbReference type="OMA" id="FMIMTYL"/>
    <dbReference type="PhylomeDB" id="Q9S1P5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="224"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB53286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="445" mass="47094" checksum="0DD50D8617331CAC" modified="2000-05-01" version="1">MSAVEAWLGVLAVFVLTAGTGYFVAQEFAYVSADRLALARQAEEGDKKAARALRVLERLSFMLSGAQLGITVTGLVVGFIAEPSVSALLRPVLSGVGIPDGAVTGISVVLAFVLATVVQMVLGELAPKNLAIAVPERLAKALAGSTLGYLKVVGPVVRIFDGAANRLLRGVGIEPVEELHHGATLEELGHLIGESHEQGELPRGTAQLLDHALEFSERTLHEVMVPRADAVFVRKDATAAEAVTLIARHGHSNYPVLGDHPDDVAGVLGVRELMGLPAGQFTATTAGAAARRPLLLPDTLPLPDAVERMREDDDEFAVVLDEHGGVAGVVTYEDIAEELVGDIADESDTVTAVAVADGEGWLVDAGRRLDEVAEATGVELPEEDDYETVAGLVVDRLGRFPAIGDRLTVELRGGGSAVIDVRTLDRHVPERIRIEWLAEKAEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1X7</accession>
    <name>Q9S1X7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0016</name>
        <name evidence="3" type="ordered locus">SCO7831</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37079">
        <property type="entry name" value="T37079"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624377.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026779.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095450"/>
    <dbReference type="GeneID" id="1103269"/>
    <dbReference type="KEGG" id="sco:SCO0016"/>
    <dbReference type="KEGG" id="sco:SCO7831"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.15"/>
    <dbReference type="eggNOG" id="ENOG5032K9B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2810444_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC03649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="7225" checksum="FB3234C9786B8BCD" modified="2000-05-01" version="1">MTTPSDDTARPVPAVLPAGPVPGHPQQEAAARLWRRRQTHTGRVYLLGPPSHRGIEDGGVEAAEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2H3</accession>
    <name>Q9S2H3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2908</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36131">
        <property type="entry name" value="T36131"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627134.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975902.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2908"/>
    <dbReference type="GeneID" id="1098341"/>
    <dbReference type="KEGG" id="sco:SCO2908"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2967"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S2H3"/>
    <dbReference type="OMA" id="HIPPWTD"/>
    <dbReference type="PhylomeDB" id="Q9S2H3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042779">
        <property type="term" value="P:tRNA 3'-trailer cleavage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="26989" checksum="9F4354F8E5B532BA" modified="2000-05-01" version="1">MKLTVVGCSGSFPSAESACSSYLVEADGFRLLLDMGNGALGELQRHCGLYDLDAIFLSHLHADHCIDMCAYFVARYYRHDGGRCAPLPVYGPEGTEHRLTTAYADTPSASSMSEVFDFHTVKPSTFEVGPFTVHTERVAHPVEAYAVRVEHGGRSLTYSGDTGATPVLDELARDTDLFLCEAAFTHGKENIPDLHLNGREAGQSAARAGARRLVLTHIPPWTDPAVNLADAREVYDGTVEVAAAGAVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2P0</accession>
    <name>Q9S2P0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2196</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35312">
        <property type="entry name" value="T35312"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626448.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976619.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2196"/>
    <dbReference type="GeneID" id="1097629"/>
    <dbReference type="KEGG" id="sco:SCO2196"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2233"/>
    <dbReference type="eggNOG" id="ENOG502ZA9M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089257_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2P0"/>
    <dbReference type="OMA" id="GDLMSNM"/>
    <dbReference type="PhylomeDB" id="Q9S2P0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="25002" checksum="59909E2D234DB52C" modified="2000-05-01" version="1">MARKEPAADAANPGRLKQIALTYKMTRKADKKIGLVLAGVGIVVFGVLLAIGFWIGHPIYLGILGLLLAFLATAIVFGRRAERAAFGQMEGQPGAAAAVLDNIGRGWTTTPAVAMNRNQDVVHRAVGKAGIVLVAEGNPNRVKSLLAAEKKKMNRIVADVPVHDLLVGTGEGQVELKKLRTTMLKLPRVLSGPQVTVTNDRLRALGDLMSNMPLPKGPMPKGMRMPRGGNPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X874</accession>
    <name>Q9X874_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3518</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36101">
        <property type="entry name" value="T36101"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627718.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029054.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3518"/>
    <dbReference type="GeneID" id="1098954"/>
    <dbReference type="KEGG" id="sco:SCO3518"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3576"/>
    <dbReference type="eggNOG" id="ENOG5030S5W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199242_0_0_11"/>
    <dbReference type="OMA" id="EGWHYAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="23092" checksum="3B149D0E961F1F2C" modified="1999-11-01" version="1">MAWRRHLPALASAAAGINEACDAWDAVSDSLCDADGWPLDDKVYGGGKVKRDAEAWKHAEVFLDHGPEVLAGVRAAADGPDYVEGPISDDLRRIRGIDTTLFRAQELRHEWADVMALMDGSQPSVLHLYKERAEEHRNTEGRHYSHELGSKGPALVRVGEYLAHRADTERPTQTERARVALTRSTHNTPGVSPASPQLPPASQPPAPGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8J3</accession>
    <name>Q9X8J3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36340">
        <property type="entry name" value="T36340"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627620.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975419.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3414"/>
    <dbReference type="GeneID" id="1098851"/>
    <dbReference type="KEGG" id="sco:SCO3414"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3477"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_2_6_11"/>
    <dbReference type="InParanoid" id="Q9X8J3"/>
    <dbReference type="OMA" id="IDRVPGC"/>
    <dbReference type="PhylomeDB" id="Q9X8J3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="15972" checksum="C500209D34DCAC4D" modified="1999-11-01" version="1">MSHVTPAFVDLVRVETRLYNAVSSRLRDEQGVSLGQFEFLEIIDRVPGCRVLDIVGELAITVGAVSKAVDRLVAAGWCVRAVNPQDRRSSVLRLTSEGDRRLAACRPVVESALASLTEVVPPDDLHRIASALAVLRAHLEAGSHGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8J7</accession>
    <name>Q9X8J7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3418</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36344">
        <property type="entry name" value="T36344"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627624.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028963.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3418"/>
    <dbReference type="GeneID" id="1098855"/>
    <dbReference type="KEGG" id="sco:SCO3418"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3481"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9X8J7"/>
    <dbReference type="OMA" id="RGRTEVW"/>
    <dbReference type="PhylomeDB" id="Q9X8J7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="33308" checksum="62C8721D36723A7A" modified="1999-11-01" version="1">MTVADAAITVEGARKEYGSKSALDGLDLTVTRGTVHGVLGPNGAGKTTLVRILSTLLRPDAGRVEVAGHDVVAEAYAVRLRIGLLGQHAALDEELGGRQNLEMFGRLHHLGARGARARADELLVRFGLSDTGRKPVGAYSGGMRRRLDLAASLITEPEVLFLDEPTTGLDPRGRAEVWDSVRSLVGAGTTVLLTTQYLEEADQLADRISVVDAGRVVADGTADELKAATGGDRVDVVLRDAGHLGAAVALLPLTGVRVDPDRRLLSAPVTDRMAALSGVVRALEEAGIEAEDVALRRPTLDEVFLHLTDRTKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Q9</accession>
    <name>Q9X8Q9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3642</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36532">
        <property type="entry name" value="T36532"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627836.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029136.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3642"/>
    <dbReference type="GeneID" id="1099078"/>
    <dbReference type="KEGG" id="sco:SCO3642"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3702"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039835_0_0_11"/>
    <dbReference type="OMA" id="MTIFLWH"/>
    <dbReference type="PhylomeDB" id="Q9X8Q9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="49"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="420" mass="44676" checksum="62F48197E9D2DE65" modified="1999-11-01" version="1">MPDLDPTPTPTPTSTPTATPTGTPSLARGALRGAAARVDAATPAGRDRAVDALRAFAILGVVLGHWLVTALVADGSSLHAASPLGEMPWLAPVSWAFQTLAVFFLVGGHVATRGYASARARGESYGRWLTARLSRLFRPVLAVLALWTVTAALLLCTGADFVTVHTLVKLALSPMWFLLVFAALTAATPLVTRLHPLWPLVVVLHIDLLRFGLGAPSWLGWVNLAAGWLVPYTLGAAWSRGELDRRRSGWILLTGGTAATAALVAWAGYPASMVGVPGASVSNLDPPTLAAVTFGLAQCGLALLLRERLRRAMRRPVAWAAIALANLSAMTIFLWHQTALMATTATGLLAGRLPGLHTRPDGLDWVAARIAWLPVFALVLAGCWATFRSCEQHGPGRRRTRVVRAHRPRRPATTAGARHV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W8</accession>
    <name>Q9X8W8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3686</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36621">
        <property type="entry name" value="T36621"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975252.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099122"/>
    <dbReference type="KEGG" id="sco:SCO3686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3744"/>
    <dbReference type="eggNOG" id="ENOG5033GYC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100184_2_0_11"/>
    <dbReference type="OMA" id="WPRSRDI"/>
    <dbReference type="PhylomeDB" id="Q9X8W8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="18814" checksum="6867A8B76E3BCCC9" modified="1999-11-01" version="1">MSDPDPPRVTRLLPDAVHQAVPRPGSAVVRLQTTHDRKGALDGAWWPRSRDITGELPSLVSALSKYLGPVTRVGLDRDAWDGLPTRMTIDGRVVHIDSFPVGDDTVLITRGGTDLFSLLVIPPHTALDAARAAMAAAVRAGSQTPAEQILIDTGTEGVGSAHAPHAVSRHGRHEPGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-25" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X913</accession>
    <name>HPPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="2 3">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="2">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hppA</name>
        <name type="ordered locus">SCO3547</name>
        <name type="ORF">SCH5.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2009" name="J. Biochem." volume="146" first="617" last="621">
            <title>Functional enhancement by single-residue substitution of Streptomyces coelicolor A3(2) H+-translocating pyrophosphatase.</title>
            <authorList>
                <person name="Hirono M."/>
                <person name="Maeshima M."/>
            </authorList>
            <dbReference type="PubMed" id="19628678"/>
            <dbReference type="DOI" id="10.1093/jb/mvp114"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MUTAGENESIS OF PHE-388 AND ALA-514</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2 3"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36668">
        <property type="entry name" value="T36668"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627745.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029076.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X913"/>
    <dbReference type="SMR" id="Q9X913"/>
    <dbReference type="STRING" id="100226.SCO3547"/>
    <dbReference type="GeneID" id="1098983"/>
    <dbReference type="KEGG" id="sco:SCO3547"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3603"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_11"/>
    <dbReference type="InParanoid" id="Q9X913"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="PhylomeDB" id="Q9X913"/>
    <dbReference type="BRENDA" id="7.1.3.1">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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            <end position="122"/>
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            <end position="183"/>
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            <end position="214"/>
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    </feature>
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            <end position="284"/>
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            <end position="341"/>
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            <begin position="365"/>
            <end position="385"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="528"/>
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        <ligand>
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        <ligand>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        <ligand>
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        <location>
            <position position="259"/>
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            <position position="723"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Increased PPase activity and H(+) pump activity. The coupling ratio is approximately two-fold that of the wild-type." evidence="3">
        <original>F</original>
        <variation>Y</variation>
        <location>
            <position position="388"/>
        </location>
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    <feature type="mutagenesis site" description="Increased PPase activity and H(+) pump activity. The coupling ratio is approximately two-fold that of the wild-type." evidence="3">
        <original>A</original>
        <variation>S</variation>
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19628678"/>
        </source>
    </evidence>
    <sequence length="794" mass="80650" checksum="1525557A88198CA8" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X930</accession>
    <name>Q9X930_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">SCO3565</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB38502.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
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    <sequence length="162" mass="16776" checksum="09679EA2141BA17B" modified="1999-11-01" version="1">MSAPDGSPVGTERSIGQLFASATTEMSALVHDEIALAKAQLKQDVKRGATSGGAFSAAGLLLLFSLPMLSFALAYGIRTWSGWNMAVCFLLSFAANVLVAGLLALIGIVFAKKAKKGRGPQKVAASVKQSAGVLQNAKPHPRPELPADRSPEAIEAVARSSS</sequence>
</entry>
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            <fullName evidence="3">Putative DNA-binding protein</fullName>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein ORF9</fullName>
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        <name evidence="2" type="primary">ORF9</name>
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    <organism evidence="2">
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="4353" last="4364">
            <title>An additional regulatory gene for actinorhodin production in Streptomyces lividans involves a LysR-type transcriptional regulator.</title>
            <authorList>
                <person name="Martinez-Costa O.H."/>
                <person name="Martin-Triana A.J."/>
                <person name="Martinez E."/>
                <person name="Fernandez-Moreno M.A."/>
                <person name="Malpartida F."/>
            </authorList>
            <dbReference type="PubMed" id="10400594"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">J1501</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
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                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="PubMed" id="12000953"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="190" mass="20620" checksum="F7B201A403574D2D" modified="1999-11-01" version="1">MDAATDDVLDAVGPRLRTLRRERGITLAHLSAATGVSESTLSRLESGQRRATLELLLPLARIYDVPLDDLVGAPRTGDPRIHLKPVRRFGMVFVPLSRRPGGTQAFKMIIPSRPAPLEPTPQTHEGSEWLYVLSGRLRLLVGERDLTLSPGEAAEFDTSLPHWLGSADGGAVELLVLFGLQGVRAHVHSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9V6</accession>
    <name>DAPD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="1">THDP succinyltransferase</shortName>
            <shortName evidence="1">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapD</name>
        <name type="ordered locus">SCO1916</name>
        <name type="ORF">SCI7.34c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36930">
        <property type="entry name" value="T36930"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626182.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976903.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X9V6"/>
    <dbReference type="SMR" id="Q9X9V6"/>
    <dbReference type="STRING" id="100226.SCO1916"/>
    <dbReference type="GeneID" id="1097350"/>
    <dbReference type="KEGG" id="sco:SCO1916"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1942"/>
    <dbReference type="eggNOG" id="COG2171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057490_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X9V6"/>
    <dbReference type="OMA" id="TVLDTWF"/>
    <dbReference type="PhylomeDB" id="Q9X9V6"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000412269" description="2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <sequence length="329" mass="33932" checksum="987355AF69F640F5" modified="1999-11-01" version="1">MTDTTAPRTSGAVAAGLATIAADGTVLDTWFPAPELSDEPGPSGTERLTAEQAAELLGGGATAAVGPDARRGVEVVAVRTVISSLDEKPVDTHDVYLRLHLLSHRLVKPHGQSLDGIFAHLANVAWTSLGPVAVDDIEKVRLNARAEGLHLQVTSIDKFPRMTDYVAPKGVRIADADRVRLGAHLSAGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDGSDIGGGASTMGTLSGGGNVRIVIGERCLVGAEAGVGIALGDECVVEAGLYVTAGTRVTMPDGQVVKARELSGASNILFRRNSVTGTVEARPNNAVWGGLNEILHSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9X5</accession>
    <name>Q9X9X5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1897</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36911">
        <property type="entry name" value="T36911"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626163.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976922.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1897"/>
    <dbReference type="DNASU" id="1097331"/>
    <dbReference type="GeneID" id="1097331"/>
    <dbReference type="KEGG" id="sco:SCO1897"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1923"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_11"/>
    <dbReference type="InParanoid" id="Q9X9X5"/>
    <dbReference type="OMA" id="LATVDHW"/>
    <dbReference type="PhylomeDB" id="Q9X9X5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB46398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27442" checksum="DF0415F48B89A42F" modified="1999-11-01" version="1">MSTRTRTTEERRHEIVRVARATGSVDVTALAAELGVAKETVRRDLRALEDHGLVRRTHGGAYPVESAGFETTLAFRATSHVPEKRRIASAAVELLGDAETVFVDEGFTPQLIAEALPRDRPLTVVTASLPVAGALAEAGDTSVLLLGGRVRSGTLATVDHWTTKMLAGFVIDLAYIGANGISREHGLTTPDPAVSEVKAQAVRAARRTVFAGAHTKFGAVSFCRFAEVGALEAIVTSTLLPSAEAHRYSLLGPQIIRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ7</accession>
    <name>NUOD2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit D 2</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit D 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit D 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoD2</name>
        <name type="ordered locus">SCO4565</name>
        <name type="ORF">SCD16A.18c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34621">
        <property type="entry name" value="T34621"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029734.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAQ7"/>
    <dbReference type="SMR" id="Q9XAQ7"/>
    <dbReference type="STRING" id="100226.SCO4565"/>
    <dbReference type="GeneID" id="1100005"/>
    <dbReference type="KEGG" id="sco:SCO4565"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4637"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_11"/>
    <dbReference type="InParanoid" id="Q9XAQ7"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="PhylomeDB" id="Q9XAQ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000357940" description="NADH-quinone oxidoreductase subunit D 2">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <sequence length="440" mass="48444" checksum="3B9EEEA384BC34F2" modified="1999-11-01" version="1">MSTSHASPRETTEGTVYTVTGGDWDEVVQSAARADDERIVVNMGPQHPSTHGVLRLILEIDGETVTEARCGIGYLHTGIEKNLEYRTWTQGTTFVTRMDYLTPFFNEAAYCLGVEKLLGIDDQIPDRATIIRVLLMELNRLSSHLVAIATGGMELGATTIMIYGFRDRELILDIYELITGLRMNHAYIRPGGLAQDLPPGAVDQIREFVKKMNKNLPEYDKLATGNPIFKARMQDVGYLDLAGCMALGATGPVLRSTGLPHDLRKTQPYCGYETYDFDVPTADTCDSYGRFLIRLEEMRQSLRIVEQCLDRLQPGPVMVADKKIAWPAQLALGPDGLGNSLDHIKKIMGTSMEALIHHFKLVTEGFRVPPAQVYTAVESPKGELGVHVVSDGGTRPFRVHFRDPSFTNLQAMAAMCEGGQVADVIVAVASIDPVMGGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y4</accession>
    <name>Q9Z4Y4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl CoA oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3247</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36195">
        <property type="entry name" value="T36195"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627459.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028855.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3247"/>
    <dbReference type="GeneID" id="1098681"/>
    <dbReference type="KEGG" id="sco:SCO3247"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3311"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_473140_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z4Y4"/>
    <dbReference type="OMA" id="GYLLDWI"/>
    <dbReference type="PhylomeDB" id="Q9Z4Y4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="PTHR10909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="258"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="600" mass="64042" checksum="A3796581F6D518FD" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y5</accession>
    <name>FABH2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2</fullName>
            <ecNumber evidence="1">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase III protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketoacyl-ACP synthase III 2</fullName>
            <shortName evidence="1">KAS III 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabH2</name>
        <name type="ordered locus">SCO3246</name>
        <name type="ORF">SCE29.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36194">
        <property type="entry name" value="T36194"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627458.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975567.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z4Y5"/>
    <dbReference type="SMR" id="Q9Z4Y5"/>
    <dbReference type="STRING" id="100226.SCO3246"/>
    <dbReference type="GeneID" id="1098680"/>
    <dbReference type="KEGG" id="sco:SCO3246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3310"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_0_11"/>
    <dbReference type="InParanoid" id="Q9Z4Y5"/>
    <dbReference type="OMA" id="VDACRQM"/>
    <dbReference type="PhylomeDB" id="Q9Z4Y5"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000110484" description="3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="1">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <sequence length="330" mass="33703" checksum="18E520075B8CE00A" modified="1999-05-01" version="1">MSAARGGRAGAVVTGVGTCLPETVVDNDEVSRHLDTDHAWIHSRTGIERRRRVSPGTTTGDLAVTAGAAALKSAGRDDCDLVLLATTTPDRRCPATAPRVASRLGLRAAAAFDLSAVCSGFVYGLSVASAMITAGTCDRALVIGADVYSSIVDPDDRGTAVVFGDGAGAVLLERGDTGDPGAVLHTELGSDGTGDELITIPPDGAYLTMRGSDVYTRAVTTMAESARSTAAHAGWDLADVDAFVGHQANLRILTSVAKRLRLPPERVVSNIADVANTAAASIPLALADAAAQGRIGSGDRLLLTAFGGGLTWGSAAVVWSGAEPVQDQRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z521</accession>
    <name>SECG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">secG</name>
        <name type="ordered locus">SCO1944</name>
        <name type="ORF">SCC54.04c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36017">
        <property type="entry name" value="T36017"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626208.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z521"/>
    <dbReference type="SMR" id="Q9Z521"/>
    <dbReference type="STRING" id="100226.SCO1944"/>
    <dbReference type="GeneID" id="1097378"/>
    <dbReference type="KEGG" id="sco:SCO1944"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1971"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_7_1_11"/>
    <dbReference type="InParanoid" id="Q9Z521"/>
    <dbReference type="OMA" id="WFACIVV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000157250" description="Protein-export membrane protein SecG">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="102" mass="10716" checksum="C3B4D9BD0EA70CDA" modified="1999-05-01" version="1">MVACCHRAPVVHRRSSESEEVGPAVVLGFSIALIVFSLLLMLLVLMHKGKGGGLSDMFGGGMQSSVGGSSVAERNLDRITVVVGLAWFACIMVLGLLMKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z533</accession>
    <name>Q9Z533_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative peptide transport permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5714</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35981">
        <property type="entry name" value="T35981"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629841.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973312.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5714"/>
    <dbReference type="GeneID" id="1101153"/>
    <dbReference type="KEGG" id="sco:SCO5714"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5804"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_11"/>
    <dbReference type="InParanoid" id="Q9Z533"/>
    <dbReference type="OMA" id="TDWFLVM"/>
    <dbReference type="PhylomeDB" id="Q9Z533"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="111"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB37469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="33556" checksum="0D5D8E0C82FACC24" modified="1999-05-01" version="1">MSAETTETTESTSGPPAKSGAPGPRALARRRRRASVARFWKEYRKHRAGVFGLATLVLFVLVALTAPLTVGSDVDSVTDAPGQPLESPSGRFPLGTDQFGRSLLGLLIWGSRVSLLVGLLAAVLSVLIGALIGITAGHFRGWYATVMMRITDWFLVMPTLVLAIVLATVLSRSLGTIVLAIGVTTWPTTARLVRAQTLAVESRPYIERAKALGGGHWHIMSRHVLPNVMPLILAQTTLIISSAILAEATLAFLGLGDPAVVSWGGLLQDAREAGSVSSGDWWYLVPPGIGIAVVALAFTLCGRAVEAVLNPRLGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBG0</accession>
    <name>Q9ZBG0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transport permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6453</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35940">
        <property type="entry name" value="T35940"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630538.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030932.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6453"/>
    <dbReference type="GeneID" id="1101892"/>
    <dbReference type="KEGG" id="sco:SCO6453"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6553"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_5_4_11"/>
    <dbReference type="InParanoid" id="Q9ZBG0"/>
    <dbReference type="OMA" id="VLMVPHA"/>
    <dbReference type="PhylomeDB" id="Q9ZBG0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="105"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA22762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="312" mass="33163" checksum="C0417CF9CF843049" modified="1999-05-01" version="1">MTSRRLRSACGVVSVAETTAGKPEGAAPAWRSRGDDRRSHRTLRLRTSAVLLTATVLAVLLVPPLVQLDQQAVDLAAKLQAPGWAHPFGTDDVGRDLLLRCVYGLRVSLLVGMAAALTATVVGTAVGATAGALGGWVDRGVMRVVDALSSVPHLLLGIFIVAMFRPGVWPVVASVALTHWLSTARIVRAEVLSLRARPHIDAAVSGGASRWRVTVRHLLPGVLPQAALAAVLMVPHAMWHESALSFLGLGLPTHTASLGNLIQEARGSLLAGQWWPTLFPGLFIIVPTLAVAGLAGAWRERINPRRRSELML</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN6</accession>
    <name>Q9ZBN6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative permease SC6C5.09</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6173</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35480">
        <property type="entry name" value="T35480"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630277.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030709.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6173"/>
    <dbReference type="GeneID" id="1101614"/>
    <dbReference type="KEGG" id="sco:SCO6173"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6283"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBN6"/>
    <dbReference type="OMA" id="WPQAMGM"/>
    <dbReference type="PhylomeDB" id="Q9ZBN6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA22507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="485" mass="49989" checksum="A2D3E18F28E7F36D" modified="1999-05-01" version="1">MTQQSVEPEITAEDAGAGSRVPGGRSWLDRYFHISHRGSTVAREVRGGITTFMAMAYIVLLNPVILSGKDAAGDTLGQKALITATAFAAALTTLLMGFVGKVPLALAAGLSVSGVIAGQVVPQMTWPQAMGMCVMYGVVIMLLVVTGLREMIMNAIPLALKHGITMGIGLFIAIIGLVKGGFVHAGEATPLTLGPAGELAGWPVLLFAGTLLLIFMLQARNMPGAILIGIVTGTIVAAILNATGVIDPEQWANGAPELHGSAVSMPDFSLFGDLEFGGWGEVGAMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLADDKGRMPGLSKALFIDGAGGAIGGVAGGSGQTVFVESATGVGEGARTGLASVVTGLFFAACLFFTPITAIVPQEVASAALVVIGAMMMMNARHVDWADRATAIPVFLTVVLMPFTYSITAGVAAGVISYVAIKVAQGRAREIGAFMWALTVIFVVYFALNPIESWLGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBV6</accession>
    <name>Q9ZBV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6562</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35004">
        <property type="entry name" value="T35004"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630643.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031008.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6562"/>
    <dbReference type="GeneID" id="1102001"/>
    <dbReference type="KEGG" id="sco:SCO6562"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6666"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_6_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBV6"/>
    <dbReference type="OMA" id="AIWHKAG"/>
    <dbReference type="PhylomeDB" id="Q9ZBV6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="34384" checksum="1A064FD69A3DDCB1" modified="1999-05-01" version="1">MKVAVLGAGAIGAYVGAALHRAGADVHLIARGPHLAAMRQYGVRVRSPRGDFTAHPRATDDPAEVGPVDYVFLGLKANSYAACGPLIEPLLHRTTAVVAAQNGIPWWYFHRHGGPYDGRRLESVDPAGAVSAVLAPERAVGCVVYAATELEQPGVVRHVEGTRFSIGEPGREVSPRCLALSEAMQSGGLKCPVEPDLRNDIWLKLLGNISFNPISALVRATMRQMCRHGGTREVIETMMTETLAVAAALGCEIGVSIERRLAGAERVGDHRTSTLQDLERGKPLELDVLLAAVVELAEITGVPVPTLRTVHALSDLLALRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-04-07" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O54125</accession>
    <name>O54125_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5929</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34601">
        <property type="entry name" value="T34601"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630047.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030538.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1101371"/>
    <dbReference type="KEGG" id="sco:SCO5929"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6026"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_8_11"/>
    <dbReference type="OMA" id="IAHPAFF"/>
    <dbReference type="PhylomeDB" id="O54125"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="28194" checksum="E1A4E953F2708D34" modified="1998-06-01" version="1">MHGTTRSTKRRLGNDTMRWDNHRVVITAAGRDFGRTLAIRLADLGAEVFLSARRLAAAQRVRDEIRDRGHQRVHAFACDLTDPASIRDFASGVAEHTDRVDVLVNNGSRYLTGPDLLSATDADVVDTIASGATGTVLTTRSFLPLLLNSDTPDVVTMVSACGTPGHHRSDAHDAFYAAKSAQAGFTEILSKRLRAQGVRVISLYPPDFDNADPLSEEWATTSREAEDALTAQSLVECILFAVAQPRDCFIKAFHFEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O54145</accession>
    <name>O54145_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RedV protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34908">
        <property type="entry name" value="T34908"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630003.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030511.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5882"/>
    <dbReference type="GeneID" id="1101324"/>
    <dbReference type="KEGG" id="sco:SCO5882"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5981"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_737252_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="395" mass="42550" checksum="EC84688BF5FC3790" modified="1998-06-01" version="1">MTTRRTDHMAAAVSTFAQALETAAGTAALSPSSHNCQPWGLGRATSTTARRSAADLTGADADEYLVLALDRERELTALAAHAVEMEVSCGVYWRILLRTLAAQGWTTAAVRVLDGDADPGAAGLPGGGRPFGAGWPTAWTPLCVVALRPGPLSGERPADLHESALARRTHRGPYGREPVAPGLLRDLEEPATPGATAHPVHLRHLTERRDLRAFAAFVARHAGRDFGHRAAWRETHSFVRRDTADATARGDGFTLEQLFGPMSRPRRAAMRLALAPTTMHLLGKVGYHRVLAAGLADVVRRTPAVVTMGFAGQAPTRAEQLEGGARLADYWWRATRHGLSLHPISIVLQHDDLRGRLERELSLPGRTFFVSRVGVAGSPAPRSHRRADAAVHVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O54162</accession>
    <name>O54162_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5933</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35698">
        <property type="entry name" value="T35698"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630050.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030542.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5933"/>
    <dbReference type="GeneID" id="1101375"/>
    <dbReference type="KEGG" id="sco:SCO5933"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6030"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045535_1_1_11"/>
    <dbReference type="InParanoid" id="O54162"/>
    <dbReference type="OMA" id="YACHRRI"/>
    <dbReference type="PhylomeDB" id="O54162"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA16190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="391" mass="40921" checksum="82FFB59F34D65513" modified="1998-06-01" version="1">MSRPSRAAPAPAEDGADQGDGISIRTPPTRVVALVTVAATVVTVVLGAVTGTAVLLIGLLVFLPAFASALCTPRQTTLVSAWVSIVVIVPVALSTEQLADRVTLALFALGFGALAVYGSWLRITREGTLVRLRSTAAAMQRQILRPLPLLTDDVLVDGVYEPVQQDKLVGGDIYDVAATPWGTRVLIGDVQGKGLPAIGMAIDVVGAFREAAHREPTVTALVDSLEAAVVRHNGYAEQRGEPERFVTAVVLGVDTGAETQLVTCGHIPPYLLHDGTVTAVGAGTEHAPLGLADLVDEPRTVSWFPFPAGATLLLCTDGLTEARSPAGAFYPLETRLAGHVDITAGRLTHALVDDVHAFTEGPQQDDLAVLTVRRSPHRMRSPSVGEVSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O69898</accession>
    <name>O69898_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5610</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34795">
        <property type="entry name" value="T34795"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629744.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030336.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1101051"/>
    <dbReference type="KEGG" id="sco:SCO5610"/>
    <dbReference type="eggNOG" id="ENOG50302KG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048348_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="120" mass="13125" checksum="A3D459EA528334E9" modified="1998-08-01" version="1">MSEIPAIRRRRASQFDHIDCGRADECPVHEPLLGHPTRKVPSQLDGAMTLAILAVAGVVSIFLFALKGVLDQVPDVIDSASRARDAWQRFKRKANEPPSPTVLRELPPPAEDEQEPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O86571</accession>
    <name>O86571_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5476</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAA20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34756">
        <property type="entry name" value="T34756"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629612.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973522.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5476"/>
    <dbReference type="TCDB" id="3.A.1.5.34">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100916"/>
    <dbReference type="KEGG" id="sco:SCO5476"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5560"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_11"/>
    <dbReference type="InParanoid" id="O86571"/>
    <dbReference type="OMA" id="VPTYFRM"/>
    <dbReference type="PhylomeDB" id="O86571"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="123"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="35744" checksum="E40DB75EF7D93CAC" modified="1998-11-01" version="1">MTAPLHEPTAEAAPSAAEEAAVAGAEAKSVQGRSLGRIAWERLKRDKLALAGGIVVLVLIVVAVFAPLITSLYGQDPNAYNEDMIDPLFGTPTGSLGGLGGEHWLGVEPVNGRDIFARIVHGARISLLVGFLSAMVAVVLGTVLGVLAGFFGGWVDSLICRIMDGLLAFPQLLFIIALVSVMPDNMLGLSGTGVRLLMMIVVIGFFGWPYIGRVVRGQTLSMREREYVEAARSLGAGRFYILFKELLPNLVAPIIVYTTMMIPTNILTEAALSFLGVGVKPPTSSWGQMLSSAIDYYKSDPMYMVVPGVAIFITVLAFNLFGDGVRDALDPKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O86736</accession>
    <name>O86736_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5663</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35435">
        <property type="entry name" value="T35435"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629793.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973362.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5663"/>
    <dbReference type="GeneID" id="1101102"/>
    <dbReference type="KEGG" id="sco:SCO5663"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5749"/>
    <dbReference type="eggNOG" id="ENOG5033A46">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107609_0_0_11"/>
    <dbReference type="OMA" id="VHDQQTV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="121"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="22634" checksum="E8F72C499F76C839" modified="1998-11-01" version="1">MTDAIRPEGEPSGGHDPWAPPESGPSLDKGPAADAGQPQQPPRQSQPPASDAPPPWQPPPGVHDQATVTSMPGAGFTGPESAVPPPPLAPGGAGVPGGYGYPGYGQGYGWPGMRTPPQNGLGTASMVLGILACALFCLYGVVSLVLGVLAVVFGIKGRRKAESGLADNHGQAQAGFVMGIVGIVLGVAVIVLIAIGITAAINEDSDGYDPYYGSARPVPVAVTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O86819</accession>
    <name>O86819_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5759</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA19860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35692">
        <property type="entry name" value="T35692"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629884.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973265.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5759"/>
    <dbReference type="GeneID" id="1101201"/>
    <dbReference type="KEGG" id="sco:SCO5759"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5848"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_6_0_11"/>
    <dbReference type="InParanoid" id="O86819"/>
    <dbReference type="OMA" id="ERWWGPP"/>
    <dbReference type="PhylomeDB" id="O86819"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="17959" checksum="EAFF4162240F1216" modified="1998-11-01" version="1">MSVTSLDKDLDNLTLTLVADFAAPVERVWQLWSDPRQLERWWGPPAYPATVEEHDLTPGGDVTYFMTGPEGEKFRGWWRVATVDAPRSLEFTDGFADEDGVPNAAMPTTANRVTLTERDGGTRMEMRAVFDTREQMEQLMTMGMAEGLREAAGQMDALLAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>P72392</accession>
    <name>FABH1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1</fullName>
            <ecNumber evidence="1">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] synthase III protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-ketoacyl-ACP synthase III 1</fullName>
            <shortName evidence="1">KAS III 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabH1</name>
        <name type="ordered locus">SCO2388</name>
        <name type="ORF">SC4A7.16</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="3946" last="3952">
            <title>Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant.</title>
            <authorList>
                <person name="Revill W.P."/>
                <person name="Bibb M.J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="7608065"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="J. Bacteriol." volume="183" first="3526" last="3530">
            <title>Beta-ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Revill W.P."/>
                <person name="Bibb M.J."/>
                <person name="Scheu A.-K."/>
                <person name="Kieser H.J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="11344162"/>
            <dbReference type="DOI" id="10.1128/JB.183.11.3526-3530.2001"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Essential enzyme that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="1"/>
    <dbReference type="EMBL" id="X86475">
        <property type="protein sequence ID" value="CAA60200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976418.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P72392"/>
    <dbReference type="SMR" id="P72392"/>
    <dbReference type="STRING" id="100226.SCO2388"/>
    <dbReference type="GeneID" id="1097822"/>
    <dbReference type="KEGG" id="sco:SCO2388"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2429"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_0_11"/>
    <dbReference type="InParanoid" id="P72392"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="PhylomeDB" id="P72392"/>
    <dbReference type="BRENDA" id="2.3.1.180">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000110483" description="3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="1">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11344162"/>
        </source>
    </evidence>
    <sequence length="343" mass="35982" checksum="7838429F06A1AF21" modified="1997-02-01" version="1">MSKIKPSKGAPYARILGVGGYRPTRVVPNEVILEKIDSSDEWIRSRSGIETRHWAGPEETVAAMSVEASGKALADAGIDASRIGAVVVSTVSHFSQTPAIATEIADRLGTDKAAAFDISAGCAGFGYGLTLAKGMVVEGSAEYVLVIGVERLSDLTDLEDRATAFLFGDGAGAVVVGPSQEPAIGPTVWGSEGDKAETIKQTVSWDRFRIGDVSELPLDSEGNVKFPAITQEGQAVFRWAVFEMAKVAQQALDAAGISPDDLDVFIPHQANVRIIDSMVKTLKLPEHVTVARDIRTTGNTSAASIPLAMERLLATGDARSGDTALVIGFGAGLVYAATVVTLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q59829</accession>
    <accession>Q9S1N0</accession>
    <name>CYSA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative cystathionine gamma-lyase</fullName>
            <ecNumber>4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cysA</name>
        <name type="ordered locus">SCO3920</name>
        <name type="ORF">SCQ11.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1995-10" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Strohl W.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / 1147</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="136" last="142">
            <title>Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Strohl W.R."/>
            </authorList>
            <dbReference type="PubMed" id="8550407"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-205</scope>
        <source>
            <strain>A3(2) / 1147</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + L,L-cystathionine = 2-oxobutanoate + L-cysteine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="4.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1"/>
    <dbReference type="EMBL" id="U37580">
        <property type="protein sequence ID" value="AAC43615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37173">
        <property type="entry name" value="T37173"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628105.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029309.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59829"/>
    <dbReference type="SMR" id="Q59829"/>
    <dbReference type="STRING" id="100226.SCO3920"/>
    <dbReference type="GeneID" id="1099356"/>
    <dbReference type="KEGG" id="sco:SCO3920"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3994"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_2_11"/>
    <dbReference type="InParanoid" id="Q59829"/>
    <dbReference type="OMA" id="GPYTYGR"/>
    <dbReference type="PhylomeDB" id="Q59829"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044540">
        <property type="term" value="F:L-cystine L-cysteine-lyase (deaminating)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114755" description="Putative cystathionine gamma-lyase">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1 and 3." evidence="3" ref="1 3">
        <original>P</original>
        <variation>R</variation>
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC43615." evidence="3" ref="1">
        <original>L</original>
        <variation>V</variation>
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="392" mass="41368" checksum="0B4A25355B1732C9" modified="2000-12-01" version="2">MSDSATTDSAGTGGERSASAPGDGTRAVRAGLPEPVKHEPTLPGPVFAAHFHLPGDPTGPYTYGRDENPTWTRLESAIGELEAPGEAGVETLVFASGMAAISSVLFSQLRAGDTAVLPDDGYQALPLVRAQLEAYGIEVRTAPTGRDAQLDVLDGAKLLWIETPSNPGLDVCDVRRLVEAAHAGGALVAVDNTLATPLGQRPLELGADFSVASGTKQLTGHGDVLLGYVAGRDAGAMAAVRRWRKIVGAIPGPMEAWLAHRSIATLQLRVDRQDSTALKVAEALRTRPEITGLRYPGLPDDPSHKVASQQMLRYGCVVSFTLPSRARADRFLDALRLVEGATSFGGVRSTAERRGRWGGDAVPEGFIRLSVGAEDPDDLVADLLRALDETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJM0</accession>
    <name>Q8CJM0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6691</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAD55387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35009">
        <property type="entry name" value="T35009"/>
    </dbReference>
    <dbReference type="PIR" id="T35551">
        <property type="entry name" value="T35551"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031109.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CJM0"/>
    <dbReference type="STRING" id="100226.SCO6691"/>
    <dbReference type="GeneID" id="1102130"/>
    <dbReference type="KEGG" id="sco:SCO6691"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6796"/>
    <dbReference type="eggNOG" id="COG3511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008770_1_0_11"/>
    <dbReference type="InParanoid" id="Q8CJM0"/>
    <dbReference type="OMA" id="YHCSFIG"/>
    <dbReference type="PhylomeDB" id="Q8CJM0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176124" description="Phospholipase C" evidence="7">
        <location>
            <begin position="30"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="8">
        <location>
            <begin position="497"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="8">
        <location>
            <begin position="602"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD55387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="687" mass="75714" checksum="F0A61BD354A9CF3C" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJQ3</accession>
    <name>Q8CJQ3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5860</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAD55236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34812">
        <property type="entry name" value="T34812"/>
    </dbReference>
    <dbReference type="PIR" id="T35896">
        <property type="entry name" value="T35896"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030503.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5860"/>
    <dbReference type="GeneID" id="1101302"/>
    <dbReference type="KEGG" id="sco:SCO5860"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5959"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_1_11"/>
    <dbReference type="InParanoid" id="Q8CJQ3"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="PhylomeDB" id="Q8CJQ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="28693" checksum="0747698FC0D4FB3E" modified="2003-03-01" version="1">MTDVTPDPLRADLLKIAQEAAHRAGELLRDGRPADLAVAATKSSPIDVVTEMDIAAEKLITGLIAERRPDDGFLGEEGAAMEGTSGSRWVIDPLDGTVNYLYGLPTWAVSIAAEQDGERVAGVVVAPMRGESYHAVLGGGAWATGAWEGERRLVCRSAAPLDQALVSTGFNYVADVRAEQAEIARRLIPLVRDIRRGGSAAIDLCDVAAGRLDGYYERGLHPWDLAAGDLIAREAGAVTGGRPGERPTGALTIAATPAVFEPLQRLLTDFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJU9</accession>
    <name>Q8CJU9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible amino acid/metabolite permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4097</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAD55470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733625.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974876.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4097"/>
    <dbReference type="GeneID" id="1099534"/>
    <dbReference type="KEGG" id="sco:SCO4097"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4156"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_2_11"/>
    <dbReference type="InParanoid" id="Q8CJU9"/>
    <dbReference type="OMA" id="CGMASVT"/>
    <dbReference type="PhylomeDB" id="Q8CJU9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD55470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="511" mass="54926" checksum="289D6F0B7832106B" modified="2003-03-01" version="1">MTEDAKASGLSDEERLAQLGYTQVLARRMSAFSNYAVSFTIISVLSGCLTLYLFGMNTGGPAVITWGWVAVGLMTLFVGLAMAEICSAYPTSAGLYFWAHRLAPPRTAAAWAWFTGWFNVLGQVAVTAGIDFGAASFLGAYLNLQFDFEVTPGRTILLFAAILILHGLLNTFGVRIVGLLNSVSVWWHVLGVAVIVGALTFAPDHHQSASFVFGEFVNNTGWGSGVYVVLIGLLMAQYTFTGYDASAHMTEETHDASTAGPKGIVRSIWTSWIAGFVLLLGFTFAIQSYDGALTSPTGAPPAQILLDALGATAGKLLLLVVIGAQLFCGMASVTANSRMIYAFSRDGALPYSHIWHSVNPRTRTPVAAVWLAALAALVLGLPYLINVTAYAAVTSIAVIGLYIAYVIPTLLRVRKGAAFERGPWHLGRWSQLVGVVAVTWVGVITVLFMLPQVSPVTWETFNYAPIAVLAVLGFAATWWLVSARHWFLNPDHERTRTRAAARASAPEPVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJV4</accession>
    <name>Q8CJV4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAD55463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36733">
        <property type="entry name" value="T36733"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029278.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3864"/>
    <dbReference type="GeneID" id="1099300"/>
    <dbReference type="KEGG" id="sco:SCO3864"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3935"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_3_11"/>
    <dbReference type="OMA" id="ATEHDTG"/>
    <dbReference type="PhylomeDB" id="Q8CJV4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="29428" checksum="2AD8FE230017FB13" modified="2003-03-01" version="1">MPKAYEVIADDLRRSIRVGERRPGDRLPSEADLAHHYRRSVPTVQNALRLLSDEGLIDKRHGLGTFVRRPRTPAVRDNRRHQWEKDRARRPLATRAETGATEHDTGLRGGDLVFHAEYRELKASGELAEAFGVPEGTVLLQRAFRTRYSAEPAPFSLVTSYLVRDLVAANPDLLDEANEPWPGGTQHQLYTVGVELDRVEERLTARPPTPEEAAALDLPPGTSVILLRKTSYDTGGRVVDVSDVTLPGDRTELLFTTRLERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWC8</accession>
    <name>Q8VWC8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.28c</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639797.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039600.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095067"/>
    <dbReference type="KEGG" id="sco:SCP2.28c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8322"/>
    <dbReference type="HOGENOM" id="CLU_2810443_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="6982" checksum="03A298921146AF04" modified="2002-03-01" version="1">MTGRRPPRRLTVREAAAVLVLTVHATAWLAVSIVQPSVPTVLTCLSAYGAALATLALVLTAGRDGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J81</accession>
    <name>Q93J81_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627045.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028601.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2816"/>
    <dbReference type="GeneID" id="1098250"/>
    <dbReference type="KEGG" id="sco:SCO2816"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2874"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_9_0_11"/>
    <dbReference type="InParanoid" id="Q93J81"/>
    <dbReference type="OMA" id="HHNMPSV"/>
    <dbReference type="PhylomeDB" id="Q93J81"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="366" mass="38820" checksum="15E471A6E778E5F1" modified="2001-12-01" version="1">MPADAAEEIRGTAHGTAPVPLSVLDLVTVGAGRTATDALRTGVDIVRLAEARGFQRYWVAEHHSMPGVASSSPAVILAHLAAHTDRIRLGSGGVMLPNHAPLVIAEQFGTLEAMAPGRVDLGLGRAPGTDGATAAALRRTDRLNEGADDFPQQLAELIRFLDDDFPDGHPYARIHAVPGPVQATSPGGVQSAHRPPVWLLGSSGFSARLAGTLGLPFAFAHHFSAQNTIPALDLYRESFRPSAVLDAPYALIGVSALATDDEKEARRQVLAAALNMVRLRTGRPGLVPTPEEAEAYDFSPMEQDFIQSWNANVIHGTADEVRSGLDDLHKRTGADELMLTANAHGGDVRLRSYELIADAYGLPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RT1</accession>
    <name>Q93RT1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630407.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972616.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6310"/>
    <dbReference type="GeneID" id="1101751"/>
    <dbReference type="KEGG" id="sco:SCO6310"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6424"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_1_2_11"/>
    <dbReference type="InParanoid" id="Q93RT1"/>
    <dbReference type="OMA" id="LFGCPAD"/>
    <dbReference type="PhylomeDB" id="Q93RT1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC37531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="447" mass="48354" checksum="8A9D50C904507E5F" modified="2001-12-01" version="1">MDATTPAVPPPGCPAHADARIPLYGPDFAADPHAYYDYARSYGPSAPVELAPGVDASLVTDYATALRLLQDNGTFRKDARRWKAFNEGLIPADSPVVPLLAYRPNAMFSDGAEHLRLRQAITDAMARIDTARLARSTEQISDYLISQFGSRGSADLMADYAKQLPLFVFNELFGCPADIGDRILFGISGMFDGVNAERAAEVLFGAVGELVALKRSRPGEDVTSWLMQHETRMTDEEMVYQLSLILGAGADPLRNLIGNTLHRILIHDEYARQGGLIDEAMEDTLWENPPVPNLAPHYPAADVEFAGQKFEAGELIMVSFAAANNSPSLAAARQSGSNRSHLAWSAGPHACPSKDPARQITMAAVENLLNRIPDIAAAVPEDSLTWRPGPFTRGLTALPARFTPLPAPDRTPAPAQAPAGERAEQSGTARKAAGTGRWSQFLNWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RT4</accession>
    <name>Q93RT4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cyclase SCIF3.09c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6307</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630404.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030814.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6307"/>
    <dbReference type="GeneID" id="1101748"/>
    <dbReference type="KEGG" id="sco:SCO6307"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6421"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_0_0_11"/>
    <dbReference type="InParanoid" id="Q93RT4"/>
    <dbReference type="OMA" id="DVIAMPL"/>
    <dbReference type="PhylomeDB" id="Q93RT4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC37528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="34117" checksum="8429B84132ADEA43" modified="2001-12-01" version="1">MTLDRTDPEGAIARAAKAYSNWGRWGEDDVLGTLNFLDGAKRREGAALVRRGVSFSLSQRFDMNGPQKGWRRRTNPVHTMLDTGTDAALGNQGFPHGIGGADDVIAMPLQCSTQWDGLGHIFDHGKAWNGRPAEQVVTSDGDLVTGIEHMAPHVAGRGVLLDVGRVVGEDGELPDGFAITEEHLAATAGAHGVRVGRGDIVLVRTGRLARARREGWGDYAGGPAPGLSFTTAGWLHGTEVAAIATDTWGFEVRPNEFEHAFQPLHQVAIPHIGLLIGEMWDLDALAEDCAEDGEYGFWLTAAPLPITGAVGSPVNPIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD03</accession>
    <name>Q9AD03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCP1.147</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639720.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039446.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095225"/>
    <dbReference type="KEGG" id="sco:SCP1.147"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8094"/>
    <dbReference type="HOGENOM" id="CLU_362049_0_0_11"/>
    <dbReference type="OMA" id="IWAYIIT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323101" evidence="3">
        <location>
            <begin position="44"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="772" mass="82298" checksum="AB5016ED840DD91B" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADD8</accession>
    <name>Q9ADD8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5069</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629220.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030035.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5069"/>
    <dbReference type="GeneID" id="1100510"/>
    <dbReference type="KEGG" id="sco:SCO5069"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5148"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="InParanoid" id="Q9ADD8"/>
    <dbReference type="OMA" id="CEHANLK"/>
    <dbReference type="PhylomeDB" id="Q9ADD8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="33897" checksum="0DBD1038714C9658" modified="2001-06-01" version="1">MRAVQFDRFGPPDVLRVNDVPAPRPGPGEVLVEVRAASVDAGETAFRAGRMRRVTRVRFPRGLGSDFAGRVAALGSGVRAWSVGDAVWGLMPHLTFGAIADYVAVPEQRLARAPQNLDLLEAAALPVVGTTAMTALSGKARLQPGERLLVRGATGGVGSVAVQLGKALGAHVTALAAARNLDWITRLGADEAVDYRTTRPEDLDRFDVIVDVVGTDLGAYRKRLARGGRLVALSFDSDRVVSSMLGIALRAAATPRRVKMFSNNPSADRIAELTRAVEAGTIRPVVDTVFPMRDIAAVHQRLEAGGVRGKYVVDLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADH3</accession>
    <name>Q9ADH3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative antibiotic resistance macrolide glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630198.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972830.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6090"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101531"/>
    <dbReference type="KEGG" id="sco:SCO6090"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6193"/>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_7_1_11"/>
    <dbReference type="InParanoid" id="Q9ADH3"/>
    <dbReference type="OMA" id="MFSIAAH"/>
    <dbReference type="PhylomeDB" id="Q9ADH3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDPGT" evidence="3">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="418" mass="45683" checksum="CC7209D7CA4C32DB" modified="2001-06-01" version="1">MKRKELHETSRLAYGRRMTTRPAHIAMFSIALHGHVNPSLEVIRELVARGHRVTYAIPPLLADKVAEAGAEPKLWNSTLPGPDADPEAWGSTLLDNVEPFLADAIQSLPQLAQAYEGDEPDLVLHDIASYTARVLGRRWEVPVISLSPCMVAWEGYEQEVGEPMWEEPRKTERGQAYYARFHAWLEENGITDHPDPFIGRPDRSLVLIPKALQPHADRVDETTYTFVGACQGDRTAEGDWARPEGAEKVVLVSLGSAFTKQPAFYRECVRAFGELPGWHTVLQVGRHVDPAELGDVPDNVEVRTWVPQLAILQQADLFVTHAGAGGSQEGLATATPMIAVPQAADQFGNADMLQGLGVARTLPTEEATAKALRTAALALVDDPEVAARLKEIQARMAQEGGTRRAADLIEAELAAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADJ4</accession>
    <name>Q9ADJ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7465</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971677.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7465"/>
    <dbReference type="GeneID" id="1102903"/>
    <dbReference type="KEGG" id="sco:SCO7465"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7576"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_3_0_11"/>
    <dbReference type="OMA" id="RAIWELC"/>
    <dbReference type="PhylomeDB" id="Q9ADJ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="125" mass="13454" checksum="92815CCCA1236692" modified="2001-06-01" version="1">MTGHDGWQPEAPELVRPYVITKGRGLPDEDDLSLITLVTAAAGQPQRPARLSPEEQSLLDLCSAGYLSVAEIAGHTHFPLGVVRILLASLMEGGHLVTRPPVARARLADKEILEEVLNGLRAKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJY3</accession>
    <name>Q9AJY3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631783.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031879.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7747"/>
    <dbReference type="GeneID" id="1103185"/>
    <dbReference type="KEGG" id="sco:SCO7747"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7868"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043255_0_0_11"/>
    <dbReference type="OMA" id="AAPHEIF"/>
    <dbReference type="PhylomeDB" id="Q9AJY3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="172"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="392" mass="42962" checksum="DE5C8291CDBCB120" modified="2001-06-01" version="1">MERPSAVERSLREAAPHEIFDVLRSAVEHRHRARTVDLLLADYAMTRLQPVGVLPHTSAPVSIHDSAPGRAFGAQEPHCVYDRSASEVTVHLPVSVRGDRLGILSVTLPESDGPAPDVLEDLQGCADALAHEVVVAERDTDLFLRARRVERLTLAAEMQWQLLPGRSCSRPEYSLGAQLEPAYAIFGDSFDWSASADDLYVTVSNGMGEGIDAALLTNLAVNALRNARRAGLSLSDQACLADQAVYGQYKGSRYLSTLLFRFHLPTGHVEIVDAGSPKVWRVRRGVVETIEMEEQMPLGMFEDTEYVPQHFQVEPGDRLLFISDGVYDALSPGGERYSVRALAASINNTRLLPAAQVPRVMLQELLGHRGATPAADDSLVLCLDWHGPSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJZ0</accession>
    <name>Q9AJZ0_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7738</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631776.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031872.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7738"/>
    <dbReference type="GeneID" id="1103176"/>
    <dbReference type="KEGG" id="sco:SCO7738"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7859"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_1_11"/>
    <dbReference type="InParanoid" id="Q9AJZ0"/>
    <dbReference type="OMA" id="PELHHGY"/>
    <dbReference type="PhylomeDB" id="Q9AJZ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901565">
        <property type="term" value="P:organonitrogen compound catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC22746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13325" checksum="015EEA9476FD4A9D" modified="2001-06-01" version="1">MTRSVITTDNAPSLPAPLSQGIRKGPVLQISGQLPFDPYTGAVVGTTVAEQTAQVLRNVTAVLEAGGAGLEDVVMLRVYLTDPAHLPELNDAYATAVGEPFPARTTVYMQLPPGLLVEIDALAVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWD3</accession>
    <name>Q9EWD3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4874</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629028.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029920.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4874"/>
    <dbReference type="GeneID" id="1100315"/>
    <dbReference type="KEGG" id="sco:SCO4874"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4954"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330064_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWD3"/>
    <dbReference type="OMA" id="NLMWLDS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="961" mass="99176" checksum="D384831147F4FFA4" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWD4</accession>
    <name>Q9EWD4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4873</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629027.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029919.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4873"/>
    <dbReference type="GeneID" id="1100314"/>
    <dbReference type="KEGG" id="sco:SCO4873"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4952"/>
    <dbReference type="eggNOG" id="ENOG5033PX7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902893_0_0_11"/>
    <dbReference type="OMA" id="DPPNDEI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC17661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="312" mass="33401" checksum="1254BC7D058EA3DC" modified="2001-03-01" version="1">MNSRSLLHSSVSRRLLRPVADLIDQRIERQVRSAVRRSAAPATADTARLVRDVEALRHRQLTVELLLGPGGRGISRMVGEASLEHLYAEVAALSGDRDAAERNVAAAFRLLVALESLGVGRIAGGTMNICGKLGTIPLLDPPNDEILEIGTLYGMFSAGLVRMMERDGRNPNLTIVDPFAGVQLQPGTDQRPDPTGAPVDEHAVRTNLALAGPAGAAARIRQGFSEDPETRAAVSDRDYGVIVVDGDHSAEGVAKDLEWAEEIAAPGAIVVLDDYDDPSWPGIKDALDDRLKGSTRFTFLGKAARSAYLRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWE9</accession>
    <name>Q9EWE9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4942</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2007" name="Nat. Methods" volume="4" first="1019" last="1021">
            <title>In situ proteolysis for protein crystallization and structure determination.</title>
            <authorList>
                <person name="Dong A."/>
                <person name="Xu X."/>
                <person name="Edwards A.M."/>
                <person name="Chang C."/>
                <person name="Chruszcz M."/>
                <person name="Cuff M."/>
                <person name="Cymborowski M."/>
                <person name="Di Leo R."/>
                <person name="Egorova O."/>
                <person name="Evdokimova E."/>
                <person name="Filippova E."/>
                <person name="Gu J."/>
                <person name="Guthrie J."/>
                <person name="Ignatchenko A."/>
                <person name="Joachimiak A."/>
                <person name="Klostermann N."/>
                <person name="Kim Y."/>
                <person name="Korniyenko Y."/>
                <person name="Minor W."/>
                <person name="Que Q."/>
                <person name="Savchenko A."/>
                <person name="Skarina T."/>
                <person name="Tan K."/>
                <person name="Yakunin A."/>
                <person name="Yee A."/>
                <person name="Yim V."/>
                <person name="Zhang R."/>
                <person name="Zheng H."/>
                <person name="Akutsu M."/>
                <person name="Arrowsmith C."/>
                <person name="Avvakumov G.V."/>
                <person name="Bochkarev A."/>
                <person name="Dahlgren L.G."/>
                <person name="Dhe-Paganon S."/>
                <person name="Dimov S."/>
                <person name="Dombrovski L."/>
                <person name="Finerty P."/>
                <person name="Flodin S."/>
                <person name="Flores A."/>
                <person name="Graslund S."/>
                <person name="Hammerstrom M."/>
                <person name="Herman M.D."/>
                <person name="Hong B.S."/>
                <person name="Hui R."/>
                <person name="Johansson I."/>
                <person name="Liu Y."/>
                <person name="Nilsson M."/>
                <person name="Nedyalkova L."/>
                <person name="Nordlund P."/>
                <person name="Nyman T."/>
                <person name="Min J."/>
                <person name="Ouyang H."/>
                <person name="Park H.W."/>
                <person name="Qi C."/>
                <person name="Rabeh W."/>
                <person name="Shen L."/>
                <person name="Shen Y."/>
                <person name="Sukumard D."/>
                <person name="Tempel W."/>
                <person name="Tong Y."/>
                <person name="Tresagues L."/>
                <person name="Vedadi M."/>
                <person name="Walker J.R."/>
                <person name="Weigelt J."/>
                <person name="Welin M."/>
                <person name="Wu H."/>
                <person name="Xiao T."/>
                <person name="Zeng H."/>
                <person name="Zhu H."/>
            </authorList>
            <dbReference type="PubMed" id="17982461"/>
            <dbReference type="DOI" id="10.1038/nmeth1118"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629094.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029965.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="PDB" id="2PZ9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A=1-226"/>
    </dbReference>
    <dbReference type="PDBsum" id="2PZ9"/>
    <dbReference type="SMR" id="Q9EWE9"/>
    <dbReference type="STRING" id="100226.SCO4942"/>
    <dbReference type="GeneID" id="1100383"/>
    <dbReference type="KEGG" id="sco:SCO4942"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5022"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_1_2_11"/>
    <dbReference type="InParanoid" id="Q9EWE9"/>
    <dbReference type="OMA" id="ITWANLE"/>
    <dbReference type="PhylomeDB" id="Q9EWE9"/>
    <dbReference type="EvolutionaryTrace" id="Q9EWE9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2PZ9"/>
        </source>
    </evidence>
    <sequence length="226" mass="24517" checksum="503F76A0AFD1A83A" modified="2001-03-01" version="1">MVAYPGPMPRSPSPGQTPDAPTSGGGSTDSTRQRIVAAAKEEFARHGIAGARVDRIAKQARTSKERVYAYFRSKEALYAHVAERETTALIEATQLDPADLPGYAGILFDHFAARPDHYRLITWGRLELAESADNTSGPLQATIAGKLDKLRDAQRIGLLDPAWDPVDVLALINQIAMTWAGQPEIAAAAADQAVDPSVTARRAALVTAVEHMFPRPDRDQRPNRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWH6</accession>
    <name>Q9EWH6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2998</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC18735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028706.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2998"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="1098431"/>
    <dbReference type="GeneID" id="1098431"/>
    <dbReference type="KEGG" id="sco:SCO2998"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3057"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499277_0_0_11"/>
    <dbReference type="OMA" id="FSAQAYC"/>
    <dbReference type="PhylomeDB" id="Q9EWH6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC18735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="573" mass="64470" checksum="585BE23E34CA6C83" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWJ0</accession>
    <name>Q9EWJ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7594</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631636.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971549.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1103032"/>
    <dbReference type="KEGG" id="sco:SCO7594"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7710"/>
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            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="348" mass="38441" checksum="CFF77941897D9C1F" modified="2001-03-01" version="1">MNHVADPSRYDGSMHYRRTGRSGLDLPALSLGYWHNFGDDKPFETQRRIALRAFDLGITHHDLANNYGPPYGSAEINFGRIMRQDLAPYRDELVVSTKAGWDMWPGPYGQGGGSRKYVLASLDQSLKRTGLDYVDIFYSHRLDASTPLEETMTALDTAVRQGKALYVGISSYDAERSRQAAAILRDLGTPLLIHQPSYNMLNRWIETEGLLDAAADEGFGVIGFTALAQGLLTGRYLDGVPEGSRATQGKSFATGWLTDDTVRRLRALNDIAARRGQSLAQMALAWALRDPRVTSLVIGASRPEQLEENVAALANPSFDDDELAEIDEYAVVDGDVDLWRRARTGDLG</sequence>
</entry>
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    <accession>Q9F2K5</accession>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
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    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO3776"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3836"/>
    <dbReference type="eggNOG" id="ENOG5031N61">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF6479"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="19324" checksum="7404B2984423772A" modified="2001-03-01" version="1">MPTGYQPPARPNRAFARQDTGTDTGADTGTDPGSGTGRDIDRDISGALSHLGVHNQNMSTAMYVLLAAPSGGAKVTVVFIIGLVIAGALVWAVRVGMRVMDREPDRPRADEQPHLPDTGAVHEEREMREPDEIPLNNDGSPRLMPYELHHSGSRRGEDQKRRRWLPGSSGAFGSGGPGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2P0</accession>
    <name>Q9F2P0_STRCO</name>
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        <submittedName>
            <fullName evidence="10">Putative ABC transport system integral membrane protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="10" type="ordered locus">SCO3110</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028773.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3110"/>
    <dbReference type="GeneID" id="1098544"/>
    <dbReference type="KEGG" id="sco:SCO3110"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3174"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2P0"/>
    <dbReference type="OMA" id="KYAMLGF"/>
    <dbReference type="PhylomeDB" id="Q9F2P0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176659" evidence="7">
        <location>
            <begin position="40"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="297"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="499"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="756"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC09551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="854" mass="89272" checksum="DED0D7CED3ABFA57" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2T9</accession>
    <name>Q9F2T9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4623</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628785.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029772.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4623"/>
    <dbReference type="GeneID" id="1100063"/>
    <dbReference type="KEGG" id="sco:SCO4623"/>
    <dbReference type="HOGENOM" id="CLU_3085022_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="52" mass="5735" checksum="4DAE183721D0682C" modified="2001-03-01" version="1">MMGFRRRAVRREGDGVGVVVTAVRELHHANVLRQLFAGFSLVRAARVAAWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2W5</accession>
    <name>Q9F2W5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4596</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628758.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974351.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4596"/>
    <dbReference type="GeneID" id="1100036"/>
    <dbReference type="KEGG" id="sco:SCO4596"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4668"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="InParanoid" id="Q9F2W5"/>
    <dbReference type="OMA" id="HDVVRKG"/>
    <dbReference type="PhylomeDB" id="Q9F2W5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="24104" checksum="63DB5F4B0FE7085F" modified="2001-03-01" version="1">MEDRVRVVIAEDSVLLREGLTRLLTDRGHEVVAGVGDGEALVKTITELDAQGELPDVVVADVRMPPTHTDEGVRASVRLRKAHPGLGVLVLSQYVEERYATELLAGSSRGVGYLLKDRVAEVREFVDAVVRVAQGGTALDPEVVAQLLGRSRKQDVLAGLTPREREVLGLMAEGRTNSAIARQLVVSDGAVEKHVSNIFMKLGLSPSDGDHRRVLAVLTYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F341</accession>
    <name>Q9F341_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5129</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629278.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973848.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5129"/>
    <dbReference type="GeneID" id="1100570"/>
    <dbReference type="KEGG" id="sco:SCO5129"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5212"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9F341"/>
    <dbReference type="OMA" id="EVAMCLA"/>
    <dbReference type="PhylomeDB" id="Q9F341"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC05759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="33373" checksum="60C11E604108D115" modified="2001-03-01" version="1">MTRTTAVGFDRVTKGYGDVRAVDGLTLALHPGETVALLGPNGAGKSTTLDLLLGLRRPDAGTVHVFGGEPREAVVAGRVGAMLQSGGLMDEVTVAELVRLGCALHPRAYPAADVLARAGLTKIADRRVDKLSGGQAQRVRFALATAGDSDLIVLDEPTTGMDVTARQAFWATMREQADQGRTVLFATHYLEEADAIADRVLVLHRGRLLADGTAAEIKARAGTRRISFDLDGGPDASPDASPDGSRNGTVDEATLRALPHLTALDVSGRTVRIQSADADATVYALYGLGLYPRNLEVAGLGLEQAFVALTAAEEAKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3E2</accession>
    <name>Q9F3E2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7615</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631656.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031781.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7615"/>
    <dbReference type="GeneID" id="1103053"/>
    <dbReference type="KEGG" id="sco:SCO7615"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7733"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="ACAPFTY"/>
    <dbReference type="PhylomeDB" id="Q9F3E2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="32391" checksum="57954A173E0924E3" modified="2001-03-01" version="1">MSEARSGAGTSAPTVLRMILGRRLHDMRQSAGASLADAARALRVTPLTIRRLEKAEVALKPLYVEKLLQTYGSGQQEIDEFVALAEQANKPGWWHAYRDVLPTWFTAYVSLETGAGTLRTYEPHYVTGLLQTPAYARGVLGGGFPNGSDEELERRVGLRLRRQSLLERENAPTLWVVMEEAVLHRVVGGPDVMREQIDRLLEASELEHVSIDILPFAVGAHVGACAPFTYFRFEEPELPDVVYSEILSASMYLDERADVVAHLEAHNRMSLLTSTRASKALLNRMRKEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L2</accession>
    <name>Q9F3L2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5252</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629398.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973718.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5252"/>
    <dbReference type="GeneID" id="1100693"/>
    <dbReference type="KEGG" id="sco:SCO5252"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5337"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F3L2"/>
    <dbReference type="OMA" id="IWLYGGA"/>
    <dbReference type="PhylomeDB" id="Q9F3L2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="194" mass="21372" checksum="E5BE98124B0DCDA3" modified="2001-03-01" version="1">MRKLTYFVACSIDGFIGGPDGDASFMVPFVDEEFFEFLKSEYPETLPTHGRRPLGIDDLPNKRFDTIVQGRASYDLALKEGVTSPYAHLREYVASRTLTESPDPNVEIISTDLVGRVRELKAEDSAFGIYLCGGSAVAGELVDEVDELVVKTYPVVLGTGMPMFGSGFEVSAFVPDSVRTFGNGVVVRTYHRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L9</accession>
    <name>Q9F3L9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5242</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629388.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030132.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5242"/>
    <dbReference type="GeneID" id="1100683"/>
    <dbReference type="KEGG" id="sco:SCO5242"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5326"/>
    <dbReference type="eggNOG" id="ENOG5033KSC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124994_2_0_11"/>
    <dbReference type="OMA" id="WSRGPAI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="15245" checksum="59E245A63491BFF1" modified="2001-03-01" version="1">MSSEQTPTPASATAEETTPRPGRLTAAAAIAALEGLALVVGGGWMLVEGLTGHPDDRTSAVTGGVTLIVLALLPLLAARGLIARRGWSRGPAVITQIMALPVAYNMVRADSLAVPAGIVLGVVAVTALVLLVNPTTTQALGIRGPGNAGKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3Q4</accession>
    <name>Q9F3Q4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative secreted endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO7633</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631673.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031790.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F3Q4"/>
    <dbReference type="STRING" id="100226.SCO7633"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="1103071"/>
    <dbReference type="KEGG" id="sco:SCO7633"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7752"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073784_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F3Q4"/>
    <dbReference type="OMA" id="TQIRPLQ"/>
    <dbReference type="PhylomeDB" id="Q9F3Q4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016289">
        <property type="entry name" value="Endo-Fsp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001103">
        <property type="entry name" value="Endo-b-N-acetylglucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176688" evidence="6">
        <location>
            <begin position="32"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="32683" checksum="3719112957C8D655" modified="2001-03-01" version="1">MKFTPVRSRVRRAALALSAVAALAVGTTATAATTGAAAAPAPRKQGPTSVAYIEVNNNSMLNAGKYTLADGGGNVFDVAVIFAANINYDTGTKSAYLHFNENVQRVLDNAATQIRPLQQKGIKVVLSVLGNHQGAGFANFPSQQAASAFARQLSDAVAEYGLDGIDFDDEYAEYGNNGTAQPNDSSFVHLVTALRANMPDKIISLYNIGPAASRLSYGGVDVSTDFDYAWNPYYGTWQVPGIALPQSKLSPAAVEIGRTSQSTSAELARRTVDGGYGVYLTYNLDGSDRSADVSAFTRELYGSEAVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBN2</accession>
    <name>Q9FBN2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5047</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629199.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973930.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5047"/>
    <dbReference type="GeneID" id="1100488"/>
    <dbReference type="KEGG" id="sco:SCO5047"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5127"/>
    <dbReference type="eggNOG" id="COG1494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBN2"/>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="PhylomeDB" id="Q9FBN2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC05892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="36552" checksum="DC147AD62CF15AAA" modified="2001-03-01" version="1">MTEHHLPSELDVPSEAPDRNLAMELVRVTEAAAMAAGRWVGRGDKNGADGAAVRAMRTLVHTVSMNGVVVIGEGEKDEAPMLFNGERVGDGTGAEVDIAVDPIDGTTLTANGMTNAIAVLAAAERGSMFDPSAVFYMDKLVTGPEAADFVDINAPVAVNIRRIAKAKRRTPEDVTVVILDRPRHQGLIKEVRETGARIKLISDGDVAGSILALREGTGIDLLLGIGGTPEGIISACAVKCLGGTIQGKLWPKDAEERQRAVDAGHDLDRVLTTDDLVSGDNVFFVATGITDGELLRGVRYRSETATTDSIVMRSKSGTVRRIDSEHRLSKLRAYSAVDFDRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC28</accession>
    <name>Q9FC28_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972088.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7056"/>
    <dbReference type="GeneID" id="1102494"/>
    <dbReference type="KEGG" id="sco:SCO7056"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7160"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124002_0_0_11"/>
    <dbReference type="OMA" id="HDQYARP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="27417" checksum="231FD9D9FA5ACA73" modified="2001-03-01" version="1">MARTTPHDPSPADPAPADAPPPLYRRVADQLLGELRDGTVPPGERLPGERRLAEHFGVSRETVRQALDVLRRDGLLTTDRRGSHVALPGPPAGSAAPLVFPVGARAAEPRTGDRATVVWGTPPPEHAAALGLVPGRPTLMHHYTSATAAGNGRRTAVTSFSAVALAEVEELARYRDRADGIACAQLRRAYDWMRRAGLTLHHRDTITLQPDTASVRVVRRVHDQYARPLEITDLLVDTRQDALVYEFTLPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC51</accession>
    <name>Q9FC51_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7135</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631196.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031452.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102573"/>
    <dbReference type="KEGG" id="sco:SCO7135"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7236"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_4_0_11"/>
    <dbReference type="InParanoid" id="Q9FC51"/>
    <dbReference type="OMA" id="CPIHKLM"/>
    <dbReference type="PhylomeDB" id="Q9FC51"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14352" checksum="6F80261CFA6AA387" modified="2001-03-01" version="1">MTTRIVTVAEGVRLTRSVSIGTHHLTADEPEPIGADEGPTPGELVLAALGSCTSMAVRALADRHEWPLERIDVAVRFGKQGEIVKNVGLTGDLEPAQREQLLAAAGRCPVHRLLAREAKIVTVPALLAEPEASHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC77</accession>
    <name>Q9FC77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7109</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631170.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031437.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7109"/>
    <dbReference type="GeneID" id="1102547"/>
    <dbReference type="KEGG" id="sco:SCO7109"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7209"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_8_1_11"/>
    <dbReference type="InParanoid" id="Q9FC77"/>
    <dbReference type="OMA" id="FMDTIEG"/>
    <dbReference type="PhylomeDB" id="Q9FC77"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="4">
        <location>
            <begin position="447"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC04215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="576" mass="62526" checksum="E127703D7547A2EE" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3L0</accession>
    <name>Q9K3L0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA protection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2014" name="Cell. Mol. Life Sci." volume="71" first="4911" last="4926">
            <title>A tale of tails: deciphering the contribution of terminal tails to the biochemical properties of two Dps proteins from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Hitchings M.D."/>
                <person name="Townsend P."/>
                <person name="Pohl E."/>
                <person name="Facey P.D."/>
                <person name="Jones D.H."/>
                <person name="Dyson P.J."/>
                <person name="Del Sol R."/>
            </authorList>
            <dbReference type="PubMed" id="24915944"/>
            <dbReference type="DOI" id="10.1007/S00018-014-1658-4"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 28-200 IN COMPLEX WITH IRON</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625345.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977779.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="PDB" id="4CYB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.78 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L=28-200"/>
    </dbReference>
    <dbReference type="PDBsum" id="4CYB"/>
    <dbReference type="SMR" id="Q9K3L0"/>
    <dbReference type="STRING" id="100226.SCO1050"/>
    <dbReference type="GeneID" id="1096473"/>
    <dbReference type="KEGG" id="sco:SCO1050"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1045"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_0_1_11"/>
    <dbReference type="InParanoid" id="Q9K3L0"/>
    <dbReference type="OMA" id="KKYHWDV"/>
    <dbReference type="PhylomeDB" id="Q9K3L0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="4">
        <location>
            <begin position="53"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB96035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="4CYB"/>
        </source>
    </evidence>
    <sequence length="200" mass="22518" checksum="78863EA01B6ECF80" modified="2000-10-01" version="1">MSSPKPKPPSSAEHRSDGSQPWLHQKGRTIQEFGTVKQFPVALTMDTRLYSCQRLNKVLADTRILHDLYKKYHWLMRGATFYQLHLLLDKHAGEQLELIDTVAERVQTLGGVAVGDPRHVAEITTVPRPPDGVEEVPSMLSRLLEAHELILTECHDAAARTQEYGDDGTNDLLVSEVLRTNELQAWFVAEHLVDTPLVHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3T8</accession>
    <name>PTH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">SCO3125</name>
        <name type="ORF">SCE66.04</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627342.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975689.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3T8"/>
    <dbReference type="SMR" id="Q9K3T8"/>
    <dbReference type="STRING" id="100226.SCO3125"/>
    <dbReference type="GeneID" id="1098559"/>
    <dbReference type="KEGG" id="sco:SCO3125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3189"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_2_2_11"/>
    <dbReference type="InParanoid" id="Q9K3T8"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="PhylomeDB" id="Q9K3T8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187826" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="200" mass="21583" checksum="AC97B9847856295E" modified="2000-10-01" version="1">MDVTTDAGAPWLVAGLGNPGPEYASNRHNVGFMVADLLAERIGARFKRHGKAQAQVVEGRIGPPGPANRRVILAKPMSFMNVSGGPVTALRDFYKVPVGNIVAVHDELDIDYGVLRLKLGGGDNGHNGLKSITKSLGADYHRVRFGIGRPPGRMPVADFVLRDFSSTERKELDYFVDRAADAVEALVIEGLERAQSAYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K442</accession>
    <name>Q9K442_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1057</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027549.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1057"/>
    <dbReference type="GeneID" id="1096480"/>
    <dbReference type="KEGG" id="sco:SCO1057"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1054"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="InParanoid" id="Q9K442"/>
    <dbReference type="OMA" id="FMSTVKI"/>
    <dbReference type="PhylomeDB" id="Q9K442"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB95276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="34937" checksum="49384EF3A715847B" modified="2000-10-01" version="1">MTTPMPTSTVGAQTPAKASEPASAPDPARIARRRRLTQWGFVAPAVVFMLLFFGYPLVRNVVMSFQDYTPKTFFTGEAPFNGADNWSNVFQDALFGKALWHTLVFTAGSLLGQFCIGLALAVFFSRRFPLNGVLRSLILLPWLVPMVVSGIVWRRILDQDTGVLNSFLDTLGIGGHTPWLTSPEMALLSVILVNIWIGIPFNMVILYGGLQEIPKELHEAAALDGASAWRTFRSVTLPMLKPVVTVVLVLGFMSTVKILDLILALTDGGPADATQTLGTLTYQNSFVQLDFGAGAVVGNVLILISAVFAVFYLRANRTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4B0</accession>
    <name>Q9K4B0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5209</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB94594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030115.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5209"/>
    <dbReference type="GeneID" id="1100650"/>
    <dbReference type="KEGG" id="sco:SCO5209"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5293"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088557_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K4B0"/>
    <dbReference type="OMA" id="TGCWSER"/>
    <dbReference type="PhylomeDB" id="Q9K4B0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="21209" checksum="B924F30208AA0C31" modified="2000-10-01" version="1">MPAARESLLDAAYTALARRPWSAVRMVDVAASAGVSRQTLYNEFGSKEGLARALVRREADGYLAGVERALSGPSDPRERLTATAEWMMSAARDNALVRAMLTGCWNERLPAPALTAVPSSCAVPAQRRADGPLPSPGDFVGLVRDRAVAVLGGAGPLPPPDAAELARSCELTVRLALSCVAAPPAEGGVADLVRTALPRRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXI5</accession>
    <name>Q9KXI5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO2335</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626582.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2335"/>
    <dbReference type="CAZy" id="GT87">
        <property type="family name" value="Glycosyltransferase Family 87"/>
    </dbReference>
    <dbReference type="GeneID" id="1097769"/>
    <dbReference type="KEGG" id="sco:SCO2335"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2372"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5650">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368383_0_0_11"/>
    <dbReference type="OMA" id="GFWLYPL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045140">
        <property type="term" value="F:inositol phosphoceramide synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="9">
        <location>
            <begin position="541"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB93455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="761" mass="81220" checksum="6EF1191014EA9F08" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXI9</accession>
    <name>Q9KXI9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626578.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028286.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2331"/>
    <dbReference type="GeneID" id="1097765"/>
    <dbReference type="KEGG" id="sco:SCO2331"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2368"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_4_3_11"/>
    <dbReference type="OMA" id="YRQHRAL"/>
    <dbReference type="PhylomeDB" id="Q9KXI9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14942" checksum="6B084533E40ACAE8" modified="2000-10-01" version="1">MATDLEVLGQAIKRAQYRNHRAMDAALRETGVSLVQWDALRAIERMPGASGHELAVATFQSDQAFGTLANRLVERGLITRSAGRGRRLDHALTESGRAALAEGRQLATGVLRDLFAPLGEEQRAQLLRALRDLTEGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXQ4</accession>
    <name>AROC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate synthase</fullName>
            <shortName evidence="1">CS</shortName>
            <ecNumber evidence="1">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroC</name>
        <name type="synonym">aroF</name>
        <name type="ordered locus">SCO1496</name>
        <name type="ORF">SC9C5.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="1">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625776.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977330.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXQ4"/>
    <dbReference type="SMR" id="Q9KXQ4"/>
    <dbReference type="STRING" id="100226.SCO1496"/>
    <dbReference type="GeneID" id="1096922"/>
    <dbReference type="KEGG" id="sco:SCO1496"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1505"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KXQ4"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="PhylomeDB" id="Q9KXQ4"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000140653" description="Chorismate synthase">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="317"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <sequence length="394" mass="41577" checksum="4603A034A35174B8" modified="2000-10-01" version="1">MSRLRWLTAGESHGPALVATLEGLPAGVPITTEMVADHLARRRLGYGRGARMKFERDEVTFLGGVRHGLTMGSPVAVMVGNTEWPKWEQVMAADPVDPEVLAGLARNAPLTRPRPGHADLAGMQKYGFDEARPILERASARETAARVALGAVARSYLKETAGVEIVSHVVELASAKAPHGVYPTPADVERLDADPVRCLDADASKAMVAEIDQAHKDGDTLGGVVEVLAYGVPVGLGSHVHWDRKLDARLAGALMGIQAIKGVEIGDGFELARVPGSRAHDEIVGTPDGIRRVSGRSGGTEGGLTTGELLRVRAAMKPIATVPRALKTVDVATGEAAQAHHQRSDVSAVPAAGIVAEAMVALVLADAVAEKFGGDSVTETRRNVRSYLDNLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXS4</accession>
    <name>Q9KXS4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029576.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4317"/>
    <dbReference type="GeneID" id="1099757"/>
    <dbReference type="KEGG" id="sco:SCO4317"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4385"/>
    <dbReference type="eggNOG" id="ENOG5031WV0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189258_0_0_11"/>
    <dbReference type="OMA" id="HGDMSAA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7542" checksum="BCC1FFE40AA1CD07" modified="2000-10-01" version="1">MPVGGWRSHHGDMSAATISPAPAPGRASGATPVAGSHRHRLGDTLRAVRVFAGAAFDVVVLGEYGEEAGVRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYD9</accession>
    <name>Q9KYD9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4131</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628309.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974839.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4131"/>
    <dbReference type="GeneID" id="1099571"/>
    <dbReference type="KEGG" id="sco:SCO4131"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4193"/>
    <dbReference type="eggNOG" id="ENOG5033XVZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2105723_0_0_11"/>
    <dbReference type="OMA" id="GNEARVM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="102" mass="10413" checksum="1111BE860ECA8A4F" modified="2000-10-01" version="1">MLFAADEGDINTIIGGIAPDWGPFGALGTEAKTMVQVVMAVAILLCLGIAIWGAAKQRIGATALRDTFSAEQGKGLIIAGLTGVFIIGSLGTLFTIVYGMAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH3</accession>
    <name>CHPG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaplin-G</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Chaplin-F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">chpG</name>
        <name evidence="11" type="synonym">chpF</name>
        <name type="ordered locus">SCO2699</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1714" last="1726">
            <title>A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Rink R."/>
                <person name="de Jong W."/>
                <person name="Siebring J."/>
                <person name="de Vreugd P."/>
                <person name="Boersma F.G."/>
                <person name="Dijkhuizen L."/>
                <person name="Wosten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="12832396"/>
            <dbReference type="DOI" id="10.1101/gad.264303"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1727" last="1740">
            <title>The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Elliot M.A."/>
                <person name="Karoonuthaisiri N."/>
                <person name="Huang J."/>
                <person name="Bibb M.J."/>
                <person name="Cohen S.N."/>
                <person name="Kao C.M."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12832397"/>
            <dbReference type="DOI" id="10.1101/gad.264403"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="433" last="443">
            <title>The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Stokroos I."/>
                <person name="Deelstra H.J."/>
                <person name="Penninga N.A."/>
                <person name="Bormann C."/>
                <person name="Salas J.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Woesten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="15228525"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04143.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="64" first="602" last="613">
            <title>SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Capstick D.S."/>
                <person name="Willey J.M."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="17462011"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2007.05674.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="1128" last="1140">
            <title>Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose.</title>
            <authorList>
                <person name="de Jong W."/>
                <person name="Woesten H.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Claessen D."/>
            </authorList>
            <dbReference type="PubMed" id="19682261"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06838.x"/>
        </citation>
        <scope>FUNCTION IN GROWTH SUBSTRATE ATTACHMENT</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E18839" last="E18839">
            <title>The assembly of individual chaplin peptides from Streptomyces coelicolor into functional amyloid fibrils.</title>
            <authorList>
                <person name="Sawyer E.B."/>
                <person name="Claessen D."/>
                <person name="Haas M."/>
                <person name="Hurgobin B."/>
                <person name="Gras S.L."/>
            </authorList>
            <dbReference type="PubMed" id="21526199"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0018839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2013" name="J. Struct. Biol." volume="184" first="301" last="309">
            <title>Chaplins of Streptomyces coelicolor self-assemble into two distinct functional amyloids.</title>
            <authorList>
                <person name="Bokhove M."/>
                <person name="Claessen D."/>
                <person name="de Jong W."/>
                <person name="Dijkhuizen L."/>
                <person name="Boekema E.J."/>
                <person name="Oostergetel G.T."/>
            </authorList>
            <dbReference type="PubMed" id="24012833"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2013.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="4491" last="4501">
            <title>Surface modification using interfacial assembly of the Streptomyces chaplin proteins.</title>
            <authorList>
                <person name="Ekkers D.M."/>
                <person name="Claessen D."/>
                <person name="Galli F."/>
                <person name="Stamhuis E."/>
            </authorList>
            <dbReference type="PubMed" id="24413917"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5463-z"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 6 7 8">One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins (PubMed:12832396, PubMed:12832397, PubMed:15228525, PubMed:17462011). Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation (PubMed:17462011). Chaplins are also involved in cell attachment to a hydrophobic surface (PubMed:19682261). Forms amyloid fibrils in vitro probably composed of stacked beta-sheets, at low extracellular concentrations individually restores the ability to form aerial hyphae to a chaplin-deficient strain (PubMed:21526199). A small chaplin extract (ChpD, ChpE, ChpF, ChpG and ChpH) self-assembles into 2 different amyloids; small fibrils at the air-water interface form an amphipathic membrane that resembles spore-surface structures involved in aerial hyphae formation, and hydrophilic fibrils in solution that resemble the fibers that attach cells to a hydrophobic surface. At the air-water interface the hydrophilic surface is in contact with water (probably equivalent to the peptidoglycan layer), while the hydrophobic face is exposed to the air, making the surface of the aerial hyphae hydrophobic (PubMed:24012833). A small chaplin extract applied to a chaplin-deficient strain restores aerial hyphae formation (PubMed:12832396, PubMed:12832397). The small chaplin extract forms an amyloid-like structure similar to that seen on the surface of cells without rodlets (rdlA-rdlB deletions), and is highly surface active, reducing surface tension from 72 to 26 mJ/m(2), which probably allows escape of hyphae from an aqueous environment into air (PubMed:12832396). ChpF and ChpG are sufficient to restore the rodlet layer and hydrophobicity to a strain deleted for the other 6 chaplin genes (PubMed:15228525).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3 14">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 3">Secreted</location>
            <location evidence="2 3">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2 14">Present in aerial hyphae of sporulating cultures (at protein level).</text>
    </comment>
    <comment type="induction">
        <text evidence="3 5 12">Not expressed while still submerged, accumulates during aerial hyphae formation on minimal medium, no transcript detected during sporulation. Strongly expressed in aerial hyphae (at protein level) (Probable). During aerial hyphae formation and early sporulation on rich medium, under control of ECF sigma factor BldN (PubMed:12832397). Expression depends on bldB but not bldA, bldD or bldH (at protein level) (PubMed:17462011).</text>
    </comment>
    <comment type="mass spectrometry" mass="5994.0" method="MALDI" evidence="2"/>
    <comment type="mass spectrometry" mass="5988.63" method="MALDI" evidence="3"/>
    <comment type="disruption phenotype">
        <text evidence="4 5 6">A strain deleted of chpF and chpG makes rodlets (PubMed:15228525). Deletion of all 8 chaplin genes on minimal medium leads to severely disrupted aerial hyphae that collapse on the colony surface and are not hydrophobic. A few spore chains can still be made, but they have neither rodlets or amyloid-like fibers. rdlA and rdlB mRNA are down-regulated (PubMed:15228525, PubMed:17462011). Deletion of all 8 chaplin genes on rich medium leads to a reduced abundance of aerial hyphae without rodlets and occasional spore chains on surface hyphae. A complete chaplin-negative plus ram-negative strain (deletion of ramR or the ramC-ramS-ramA-ramB operon) leads to the complete loss of robust aerial hyphae (PubMed:17462011). Deletion of all 8 chaplin genes significantly reduces cellular attachment to a hydrophobic substrate; thin fibrils instead of fimbrae are detected. The long chaplins (ChpA, ChpB and ChpC, as seen by near wild-type attachment of the hextuple chpA-chpB-chpC-chpD-chpE-chpH knockout) are not essential but may contribute to attachment (PubMed:19682261).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="9">The small chaplin mixture (a cell wall extract of an rdlA-rdlB knockout) forms a stable coat on a number of surfaces (including Teflon and cotton) and emulsifies oil-water mixtures, which could be useful in medical and technical applications.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the chaplin family. Short chaplin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626933.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028524.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KYH3"/>
    <dbReference type="STRING" id="100226.SCO2699"/>
    <dbReference type="DNASU" id="1098133"/>
    <dbReference type="GeneID" id="1098133"/>
    <dbReference type="KEGG" id="sco:SCO2699"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2754"/>
    <dbReference type="eggNOG" id="ENOG50348JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145456_3_0_11"/>
    <dbReference type="OMA" id="CANVEMH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0034">Amyloid</keyword>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2 3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004328512" description="Chaplin-G">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="15228525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="19682261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="24012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="24413917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="90" mass="8468" checksum="BB575924572758B3" modified="2000-10-01" version="1" precursor="true">MSRIAKAAGVALGTGAVVLSGTGMAMADAGAAGAAVGSPGVLSGNVVQVPVHVPVNLCGNTIDVIGLLNPAFGNACENGDDDDKSGGYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYL7</accession>
    <name>Q9KYL7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7370</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631423.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031616.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7370"/>
    <dbReference type="GeneID" id="1102808"/>
    <dbReference type="KEGG" id="sco:SCO7370"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7475"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_11"/>
    <dbReference type="InParanoid" id="Q9KYL7"/>
    <dbReference type="OMA" id="TISEVWH"/>
    <dbReference type="PhylomeDB" id="Q9KYL7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB92213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="346" mass="35688" checksum="9A99BBE52A48290F" modified="2000-10-01" version="1">MMPMAAFSPRGESRTPWGRVLVTGGAGFLGSHLCTRLLDAGAEVDCLDNLSTGRAEKVAHLAGRPGFRFLERDISAPGCADALTGPYDLVLHLAGPASPAARPDRPVEALDAGSLGTRTALSVAGRDGARFLLASSPPAGPGTRGDAPDDADPVGPHRACAEAVRFAEALVAAHAGANGSNAGIVRLFDGYGPGMRTDGAGTPAALIEAALTGRPVTVPGDGSGTYPLCYVDDMVDGVLLVAAGRSVRPVDIGGDEEPTAAEIARLVIELTGSDSPLAFVEDAGDGRPRPRPVTGFAREIFGWLPSVAWQDGLERTVAAFRDRPDPVPTATREPAGERMGEWWAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ33</accession>
    <name>Q9KZ33_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7099</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631160.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031429.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7099"/>
    <dbReference type="GeneID" id="1102537"/>
    <dbReference type="KEGG" id="sco:SCO7099"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7199"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ33"/>
    <dbReference type="OMA" id="ETYRRWY"/>
    <dbReference type="PhylomeDB" id="Q9KZ33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="32523" checksum="24DCF8789B260A36" modified="2000-10-01" version="1">MGGTGDTTPLAELLDERQHLIDVARWMLGAGTTAEEAVTETYRRWYGLTDAERSGISDPRVWLTRNTGTICLARLSAPARRPPGPGGAGDGIGTEPDRALSKEVSDVLLSALDALSPSERAVFVLNDVFAMPPRTVADIVGRTPHECAELAESARRSLRADGARPTPSDQHDRIVRAVRQACVLNDARHLVSLLSRHAIAFFDGGGKIRALTRPVHGDQHVARTLLTLLAPRPRTVLHLQAANGRTAIVVRHHDRVAAVISFDITDQRVTHVWAVLNPDKLRGWNRPHPPADGHGAVGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ56</accession>
    <name>Q9KZ56_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component response regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7075</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89747.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631137.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972069.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7075"/>
    <dbReference type="GeneID" id="1102513"/>
    <dbReference type="KEGG" id="sco:SCO7075"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7181"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="InParanoid" id="Q9KZ56"/>
    <dbReference type="OMA" id="LMLTARC"/>
    <dbReference type="PhylomeDB" id="Q9KZ56"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB89747.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="25772" checksum="69FE46AEC523CD49" modified="2002-10-01" version="2">MRIMIADDDAAIRASLERVLQVEGYDTSTVANGFAVLDEVGGADGDTLDLLLLDVMMPRLGGLETCRRLRAAGRDLPVLMLTARDQVSDRVTGLDAGADDYLPKPFATEELLARVRALLRRRTPADEESHILSFADVRLDSDRFEAWRGRRPLHLTRTEFSLLEVLLCNATRVLTRDALFEAIWGFGMSSTANNLQVYVSYLRRKMEAEGEPRLIYTVRGLGYTLRETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ66</accession>
    <name>Q9KZ66_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3082</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627302.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975729.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3082"/>
    <dbReference type="GeneID" id="1098515"/>
    <dbReference type="KEGG" id="sco:SCO3082"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3143"/>
    <dbReference type="eggNOG" id="ENOG503302F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181596_0_0_11"/>
    <dbReference type="OMA" id="IPHCTGR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="76" mass="9029" checksum="2C3F1A9B401D9494" modified="2000-10-01" version="1">MSQVFSEETHRNLLARIPQCTGREISDWLRAVEDGPALFRFEEKVSWLRHEHNLSYGHAKAIVHEYDLRRAARKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZJ1</accession>
    <name>Q9KZJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1154</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625446.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027615.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1154"/>
    <dbReference type="GeneID" id="1096577"/>
    <dbReference type="KEGG" id="sco:SCO1154"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1152"/>
    <dbReference type="eggNOG" id="ENOG5033V4B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061801_0_0_11"/>
    <dbReference type="OMA" id="FYVNRYR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045652">
        <property type="entry name" value="DUF6397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19934">
        <property type="entry name" value="DUF6397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="35343" checksum="8383A74C93590149" modified="2000-10-01" version="1">MSGNTITHDVAAAGERTGTTRGTSVTHHRAARELGLRRSEFDLAVHLGRVRTVPDDAGGGRRVPRDEIDRVRAADGFPEALRAAVRAVGTTEGAALMDVTTARFTRLARLGLLVPVKFYVNRYRAVVWLYLAAELQQFRTDEHNTALLKGRTPEGLREQLGEGLDLRPRNWRGRHLGFLLRQADDSWARAAAVASLLDAAEISDVVTDPYERSHLRRFRPARVVHGSPGSPAAQLAEEIVTAGDPDEVDWLRSDLAAAVATARRHRPAPRPATHGVPHPPGPEPLPRETAEPVPPEGENAAPRAARQPGRLSGLFGRLRRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZL0</accession>
    <name>Q9KZL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3035</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627257.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028726.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3035"/>
    <dbReference type="GeneID" id="1098468"/>
    <dbReference type="KEGG" id="sco:SCO3035"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3095"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102185_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KZL0"/>
    <dbReference type="OMA" id="TTRWYHR"/>
    <dbReference type="PhylomeDB" id="Q9KZL0"/>
    <dbReference type="BRENDA" id="1.13.11.20">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q9KZL0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17861" checksum="8E3E332579118394" modified="2000-10-01" version="1">MNSDSDLQIAGDILEVPHLLQAPREHPATVAEFAGLLRSVAADRSEWGHLVRYDATTRWYHRLRTGPGYEVWLLSWVPGQGSGRHDHGPSSGVWTVLEGTLTEHTERGTRALDAGTQRVFAPGYVHEVVNDALGPAVSLHVYYPGLTEMPMHSPQCSAAAVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZM4</accession>
    <name>Q9KZM4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3020</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S03775">
        <property type="entry name" value="S03775"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627242.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3020"/>
    <dbReference type="GeneID" id="1098453"/>
    <dbReference type="KEGG" id="sco:SCO3020"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3080"/>
    <dbReference type="eggNOG" id="COG1300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069787_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZM4"/>
    <dbReference type="OMA" id="QVWTNNA"/>
    <dbReference type="PhylomeDB" id="Q9KZM4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="36228" checksum="B3B283792A2F80B4" modified="2000-10-01" version="1">MDLDVFVSAHRAEWDRLDALLRRRRRLTGPETDELVALYQRTATHLSLIQSSAPDPQLTGRLSQLVARARSVVTGTRRASWRDVTRFLTQQFPAAVYRARHWWVPTALLSTAVAALLGWWIGTHPEVQSTIAAPSELRELTRPGGQYETYYSSNPAASFAAQVWTNNAWAAALCLILGVFLGLPVIWILFQNMLNLGVGFGLMSSAGRLDTFLGLVLPHGLLELTAVFVAAGTGLRLGWTLIDPGPRTRRIALAEEGRAAIGMAVGLALVLFVSGAIEGFVTPSGLPTWARITIGVLAELAFLAYVYVLGGRAVRDGETGDVEAAERSATVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZX0</accession>
    <name>Q9KZX0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4456</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628623.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029665.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4456"/>
    <dbReference type="GeneID" id="1099896"/>
    <dbReference type="KEGG" id="sco:SCO4456"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4526"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023173_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9KZX0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="528" mass="56920" checksum="F727674F9FF4D44D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0D9</accession>
    <name>RL4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">SCO4703</name>
        <name type="ORF">SCD31.28</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628862.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974266.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0D9"/>
    <dbReference type="SMR" id="Q9L0D9"/>
    <dbReference type="STRING" id="100226.SCO4703"/>
    <dbReference type="GeneID" id="1100144"/>
    <dbReference type="KEGG" id="sco:SCO4703"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4774"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_0_11"/>
    <dbReference type="InParanoid" id="Q9L0D9"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="PhylomeDB" id="Q9L0D9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129287" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="219" mass="23643" checksum="F2FAC3DCF1855075" modified="2000-10-01" version="1">MSTVDILSPAGEKTGSVELPAEIFGVEKISIPLIHQVVVAQNAAARQGTHKTKRRGEVRGGGKKPYRQKGTGRARQGSTRAPQFAGGGVVHGPQPRDYSQRTPKKMKAAALRHALTDRARHNRIHVVTGVIEGENPSTKAARTLFGKISERKNLLLVVDRADEAAWLSARNLPQIHILEPGQLNTYDVLVSDDVVFTQAAFESFVSGPNKAVDTEGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0N3</accession>
    <name>Q9L0N3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4258</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628432.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029536.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4258"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1099698"/>
    <dbReference type="KEGG" id="sco:SCO4258"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4325"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045395_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0N3"/>
    <dbReference type="PhylomeDB" id="Q9L0N3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="327"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB77352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="485" mass="52597" checksum="269122D1B6A4D6FA" modified="2000-10-01" version="1">MSLWTSLEPASATVDPGSSTRVRLRVRNTGDVVDEYRFEPVGDVAPWTTVEPQTLRLYPGTTGTVELTFAPPRTSDAVAGPNPYAVRILPTEHPDAVTVPEGNLTITAFTEVRAELVPPTVKGRFRGRPRLAVDNLGNTKVTASIAGSDHGDHLSYEVRPGNVQIEPGRAAFVETTLKPKRIIWFGAKEERPYTLAVRRSGVDPTEIEGTYVQRGFLPRWLATFFGIFLALAIAFVMIWIAYKPQVRTSATEQTEQAGVALAPSPSATPETLPSSAESAPVEQPQVQQPPGTQEPEKDKGDGDGGDKGGGGEAKKPAKPAAKPVVPAQNILLRNTTSHMCAELPGREKGELDGPVQQAVCDDTDGDNQIWNLEVKYAKAGPGGTDLFQIRNIKDQYCMDLPYHGAVAVGTPVTEFKCDSTSATDNQFWWVDKQESGAYWIRNFSSNQKCLGVEGANGGALFSKMVLDNCSNVDDQEWEIIHPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0N7</accession>
    <name>Q9L0N7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628428.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029532.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4254"/>
    <dbReference type="GeneID" id="1099694"/>
    <dbReference type="KEGG" id="sco:SCO4254"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4321"/>
    <dbReference type="eggNOG" id="ENOG503088D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308571_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="PTHR15746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="866"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="956" mass="101196" checksum="F67B04C6D615F00B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0W5</accession>
    <name>Q9L0W5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3739</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627930.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029199.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3739"/>
    <dbReference type="GeneID" id="1099175"/>
    <dbReference type="KEGG" id="sco:SCO3739"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3800"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_11"/>
    <dbReference type="InParanoid" id="Q9L0W5"/>
    <dbReference type="OMA" id="GPRMPRD"/>
    <dbReference type="PhylomeDB" id="Q9L0W5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="334" mass="35153" checksum="F4983A3F730C9270" modified="2000-10-01" version="1">MRVLVTGSAGFIGSHVVEALREHGHEPVGYDVREDPGADVRDPAALARALAGVDAVCHQAAMVGLGNGFADAAEYVSRNDLGTAVLLAATAGAGVRRLVLAGSMVVYGEGRYTCARHGVVRPGPRAVADLDAGRFEPTCPRCGADLAPGLVGEDAPADPRNVYATTKLAQEHLAAAWARTTGATAVSLRYHNVYGPRMPRDTPYAGVASFFRSALARGEAPRVFEDGRQRRDFVHVRDVAAANVAALESARPPEGALSAYNTGSGEPHTVGEMAVALSAAHGGPEPVVTGEYRLGDVRHITADSARLRTDLDWRPRVGFAEGMREFARDGLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L156</accession>
    <name>Q9L156_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport protein, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7459</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631507.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031676.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7459"/>
    <dbReference type="GeneID" id="1102897"/>
    <dbReference type="KEGG" id="sco:SCO7459"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7570"/>
    <dbReference type="eggNOG" id="COG1119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="InParanoid" id="Q9L156"/>
    <dbReference type="OMA" id="MDEPCAG"/>
    <dbReference type="PhylomeDB" id="Q9L156"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB76322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="279" mass="30491" checksum="36C39CAD8401E436" modified="2000-10-01" version="1">MTAQTARSQADEDEAAVLRLQDVSVRRFTPDQLILDGVNWTVRPGEHWALLGANGAGKTTLLRLLGALMHPTTGTVEVLGSRLGRVDVRELRARIGHVNSAQRVPQDLTAHAVVLTGHSGTVQPLWRTYGEEVRLRARDLLLELGVKELADRPYGVCSGGQRARVLIARALMANPALLLLDEPFNALDLPSREDLVEAMHQLAERRPRLATVTVTHHLEELSPAVSHALLLREGRILSRGAVDEVLTGSLLTSCFGRDITVARRDGRWSAYSGRRVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1A7</accession>
    <name>Q9L1A7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1574</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027857.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1574"/>
    <dbReference type="GeneID" id="1097005"/>
    <dbReference type="KEGG" id="sco:SCO1574"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1586"/>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065810_0_0_11"/>
    <dbReference type="OMA" id="DITAVRM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="21350" checksum="165564D7FCE2D71B" modified="2000-10-01" version="1">MAAQSPQGGRGAGAGTVTGDAARTQYGPVQVRLTVSGGKITGAEAVQAPKGGQSDQVTADAVPKLNRAAVAAGSADIDAVSGATYTSAGYVKSLQSALDKAAAAAGPAAQESSGADSGSGGGGRSEGDAGQGTQVLTGDAAQTQYGPVQVRVTVSGGRITDVEALQAPKGGRSDQVTADAVPRLNRAAVAAGTADIDAVSGATYTSAGYTQSLQSALDRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1I9</accession>
    <name>Q9L1I9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2728</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626961.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976072.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2728"/>
    <dbReference type="GeneID" id="1098162"/>
    <dbReference type="KEGG" id="sco:SCO2728"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2784"/>
    <dbReference type="eggNOG" id="ENOG50343N9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048455_0_0_11"/>
    <dbReference type="OMA" id="CHKSARR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB75317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="15640" checksum="3838A65417619187" modified="2000-10-01" version="1">MWHSCHKSARRVTHVTRTRVFRHTRERALTVRHPASFTRNRLGDRQRSARLPPAAVPGRRRGARREVRLVTDRRLWSYKDIAAHIKVQPDTVRSYRKHGLLPPPDHVEGGKPYWYAETVRAWVASRPRNRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1M4</accession>
    <name>Q9L1M4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6891</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630961.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031276.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6891"/>
    <dbReference type="GeneID" id="1102330"/>
    <dbReference type="KEGG" id="sco:SCO6891"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7001"/>
    <dbReference type="eggNOG" id="ENOG503189D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139806_0_0_11"/>
    <dbReference type="OMA" id="ERRFAMS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17086" checksum="E575D7D33A0C7386" modified="2000-10-01" version="1">MTDGISEESADVVGVLTERIEARFDMGMDQLKAAVAAAPTANPDATDVVKWHGLLVEAQSVLERAEDDLLAALQPRPSEVDDPTMGLAHRVNAAVTVRDGRAMVVRWLLDPDAPGKKDLAAQRLARLRPRSGPAVQTIAPNRPAGTPAPASTWRPARSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Q8</accession>
    <name>Q9L1Q8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6856</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630926.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031241.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6856"/>
    <dbReference type="GeneID" id="1102295"/>
    <dbReference type="KEGG" id="sco:SCO6856"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6966"/>
    <dbReference type="eggNOG" id="ENOG50321PW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244741_0_0_11"/>
    <dbReference type="OMA" id="DYHRLPH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="22724" checksum="A7F9D7E5D5FB8BE6" modified="2000-10-01" version="1">MNQTEPNFWVLEYVTITKDSRTGLVVAIGGTEQAADILQRTGGFVTAPGPRGDYHRLPHGLPIEQQRLKATGASHALLTAGHSVHLDPALNMLATPDGDRDAALRYLTQLAERASAAETSSAVAEVLTEVAAPVHGLLPLTREVVARAWITASNLQGAAPGEEPEPIARLGSTTNSLSEAARAMLHARNHAARPTQPPPTAPAPGRAQSPVSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1U2</accession>
    <name>Q9L1U2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2953</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2953"/>
    <dbReference type="GeneID" id="1098386"/>
    <dbReference type="KEGG" id="sco:SCO2953"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3012"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056526_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1U2"/>
    <dbReference type="OMA" id="PKWGYGI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB72199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="27256" checksum="5B57B229F82B24A6" modified="2000-10-01" version="1">MQGTPAPNEHETVGAYALGILDDAEATAFEAHLATCEWCAQQLDELAGMEPMMAALADLPGTGTPAVAESLTVKPSARLSEKLVDEVAERRASKRRRNFYLVGTAAALIIGGPFAAVATTGGGGGGGDDGGGRRAEATQQAASPAESAFAAMPDRVTATDPGTQVSATVALEKKAWGTETVLELKNLKGPQKCSLIAVGKNGERETLTSWSVPDWGYGIPGATTEKAKKPLYVHGGAAFEPNQISHFEVMTFDGKRLVEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L210</accession>
    <name>Q9L210_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6822</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630894.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031209.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102261"/>
    <dbReference type="KEGG" id="sco:SCO6822"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6931"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q9L210"/>
    <dbReference type="OMA" id="VMFYLPI"/>
    <dbReference type="PhylomeDB" id="Q9L210"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="13"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB71269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="521" mass="52863" checksum="A65AD81A0726AEA7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2G0</accession>
    <name>Q9L2G0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2523</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB69744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626763.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2523"/>
    <dbReference type="GeneID" id="1097957"/>
    <dbReference type="KEGG" id="sco:SCO2523"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2568"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="FHRWTRQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of cell division"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="305" mass="33634" checksum="0623CEA865195A57" modified="2000-10-01" version="1">MLVFAASDKGGTGRSVTSANLAYQRALTGDHVAYVDFDFGSPTAAAVFDVPSAMRGTQERGLHSYLEGDTSEPVRIDVWRETEHPLLRARPNQSGRLVLFPGDAGGGEFATGEEALERCVDLLLKLNAEFDVTFVDLSAGRSYAVDMVLDATAHPRMRNTPFRWLVFHRWTRQHVIAASGLVHAEHGIIGGGVERGHDEDDLRAAIRFVRAAVPDPESPLWSQGSTAQATWMQACDEALRRLAAEQRIGDSVVLGIVPLEPILQWQEQLITEEDVLSTQIANKETLEALEEIARRLTDDTHWGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2J4</accession>
    <name>Q9L2J4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0715</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625020.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978147.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096138"/>
    <dbReference type="KEGG" id="sco:SCO0715"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.703"/>
    <dbReference type="eggNOG" id="ENOG5033YYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151275_0_0_11"/>
    <dbReference type="OMA" id="WFRWSDE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="123" mass="13824" checksum="9497D5DCDC869205" modified="2000-10-01" version="1">MGFEGEVWHVRRAPDAGGAADAESADIGEIRIDEADFPWLSGRFRAGPAYGAVRDLFARELALAQADDAEHWTRWEAVHDEIERRVRLVSPDGPVAEFLLHIKGDRAWFRWSDEPFGPARPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDD1</accession>
    <name>Q9RDD1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2560</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626798.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028427.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2560"/>
    <dbReference type="GeneID" id="1097994"/>
    <dbReference type="KEGG" id="sco:SCO2560"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2605"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014270_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RDD1"/>
    <dbReference type="OMA" id="WCAVWLE"/>
    <dbReference type="PhylomeDB" id="Q9RDD1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="551"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="792" mass="81805" checksum="EFE7CC6D66852D3D" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDE7</accession>
    <name>Q9RDE7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative IclR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2544</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626782.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028419.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2544"/>
    <dbReference type="GeneID" id="1097978"/>
    <dbReference type="KEGG" id="sco:SCO2544"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2589"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_3_11"/>
    <dbReference type="InParanoid" id="Q9RDE7"/>
    <dbReference type="OMA" id="GRRQGYY"/>
    <dbReference type="PhylomeDB" id="Q9RDE7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="79"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB66222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="28638" checksum="C53577C61E389252" modified="2000-05-01" version="1">MSETGDATPGGVREVKSAARTVELLEVLAARGDRPARLQELADELGVPRSSMYALLQTLISRGWVRTDVTGSLYGIGIHALLTGTSYLDSDPRVRAVRPYLDEASEALGETIHLGRLDGHDVAYLATRESHEYLRTISRVGRRLPAHVGALGKALLAERPDADLPEGPYEAFTPNTHTGREALAADLARTRERGYSVDREEGVAGIVGFGFALRYDVPALDAVSCSVPVARLTPDHEARIVAVMREIRAKLEATVPVGGGSIHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ1</accession>
    <name>Q9RDJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2734</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626966.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028550.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2734"/>
    <dbReference type="GeneID" id="1098168"/>
    <dbReference type="KEGG" id="sco:SCO2734"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2790"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OMA" id="PYLAAWP"/>
    <dbReference type="PhylomeDB" id="Q9RDJ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="344" mass="36944" checksum="7D19B9E549383411" modified="2000-05-01" version="1">MERREIEIFLTVGEELHFGRSAERLHVSVAMVSKTVQKLERSVGAALFERTSRRVAFTAIGRRLFEDLKPAHQAVLDAFARAVAAGRGVDGVLRVGFLGTATAEFVVRAAELLRTRHPGCEVRLHESRFTDGTAPLRDDVIDVLLIDNFAAPLSTLAPEHGAGPVLFREAPMLAVSARHPLARREAVDVAELARYEVLRPRAAAEQSVRASTPGQAARWVAPEGAERLFAAGRADAPSFPLGGAPGGRAAGRSTEFGSVQEMWALVGAGHGVFPVPTHASVYDARPDVAFVPVEGAPAYEWRLVWLAAADNNRVRAFSEAACDYVAAHPDPLTATARAPRGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDL8</accession>
    <name>Q9RDL8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2568</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626806.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028432.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2568"/>
    <dbReference type="GeneID" id="1098002"/>
    <dbReference type="KEGG" id="sco:SCO2568"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2613"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDL8"/>
    <dbReference type="OMA" id="YRTGAND"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB66246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="36853" checksum="E1E9D0A574CCABDE" modified="2000-05-01" version="1">MALRSRSRTASATSGPGRAPASDGRLAHRRAPGSRTHARHRSHARHGRRHAAPEELRRRAETLFAERAEGYDHAGHEGAHGETGKGPPLPGLDAPARQGSPLPGLDAPTGPGTAWRERAGSALRERMPLWLQTRCGLERRSVAALSVLLVVAAVFAVQHFWTGRTHPVAAPEVVREAAAYGAGKPEPTAEDRDTAGGSGPKAAATATAGPEIVVDVGGKVRDPGVHSLPAGSRVADALRAAGGVRPGTKTDGLNRARFLVDGEQVIVGAPAPVPRPGAGPAPDGPTGAAGPAAPVSLSTATTDQLDTLPGVGPVLAQHIIDYRTQHGGFRSVDELREVNGIGERRFADLRDLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB6</accession>
    <name>Q9RJB6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0648</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624957.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027271.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RJB6"/>
    <dbReference type="STRING" id="100226.SCO0648"/>
    <dbReference type="GeneID" id="1096071"/>
    <dbReference type="KEGG" id="sco:SCO0648"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.632"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RJB6"/>
    <dbReference type="OMA" id="AWDSFFH"/>
    <dbReference type="PhylomeDB" id="Q9RJB6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="63"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="231" mass="24973" checksum="B96560B63C9F5C36" modified="2000-05-01" version="1">MPGHRLTAPKGPTVVTDDQEHPRAAAAFDALGVEYEKAFAASKTHRRSLEWLLARLAPGSRVLDVGSGTGRPTAETLAGAGHEVLGVDVSPVMVELAARQVPAATFRCADIRDVPLADESFDAVCVYFSLLQLDRAEQKDLVRRLVRLLRPGGHLVLATVPLDVEGVDATFMGQPVRVTSFPAQELIALAEEAGLEVLAQEASMFTPVHPDARPEPHLFLHCRRPQPPRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJL1</accession>
    <name>Q9RJL1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0377</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027067.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0377"/>
    <dbReference type="GeneID" id="1095800"/>
    <dbReference type="KEGG" id="sco:SCO0377"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.353"/>
    <dbReference type="eggNOG" id="ENOG502ZQAQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100227_0_0_11"/>
    <dbReference type="OMA" id="HGYAHYI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="18030" checksum="9A6CCB7495F68C69" modified="2000-05-01" version="1">MPEGAGRGSAGGVAPRGILRRRPERWLFKGIYGLVLASALVAALDVPGEAANPGQDALWVLLTALTSGAAHGYAHVIAQRASGDGTAGPSRLRAVLAEWPLAVAVLPTVMMLLAAEAGWWAEETAADTALVLNTVLLFALGTSAARTAGLGRLSSCRAGALDMLIGLVIIAADALIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJV1</accession>
    <name>Q9RJV1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027051.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0359"/>
    <dbReference type="GeneID" id="1095782"/>
    <dbReference type="KEGG" id="sco:SCO0359"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.335"/>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100195_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJV1"/>
    <dbReference type="OMA" id="AGWHGGI"/>
    <dbReference type="PhylomeDB" id="Q9RJV1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="26314" checksum="92E77E6C84645815" modified="2000-05-01" version="1">MRPHRGHVERAEGAWREQHMSMRKALVVRGGWEGHDPVGCTESVMPALERAGFEVEIAEDLAVYEDPGLLAATDLVVHSWSAGGLTADQEANLVDAVEAGTGFAGWHGGVVATNVANPRYLRMVGGRFLWHPDGFKEFTVRIRATPDRDGEIVEGVTDYDVQTEHYWVLTDSLNTVLATSVLTPGPADPWDEPVEFPVVWTRRWGAGRVFICTLGHRVADLRVPQTAAIVGRGLVWAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJX4</accession>
    <name>Q9RJX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1196</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625486.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027645.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1196"/>
    <dbReference type="GeneID" id="1096619"/>
    <dbReference type="KEGG" id="sco:SCO1196"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1195"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031561_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RJX4"/>
    <dbReference type="OMA" id="QRVRFWA"/>
    <dbReference type="PhylomeDB" id="Q9RJX4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176915" evidence="1">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="31471" checksum="E6DAE809024502C3" modified="2000-05-01" version="1">MALTTRRRALTTLGAALTGAVALPAGTALASQGGHGPRPLWRAHAHNDYEHPRPLLDALDHRFGSVEADIYLVGGQLLVAHDPEDLDPSRTLESLYLDPLAARVRAHHGRVYRRDRGSLQLLIDIKTEGEATYLELDRRLRRYKNLFTSYAHGRVFPGAVTAVVSGDRAARAPMAAQRSRRAFYDGRLTDLGTVAPASFVPLISDNWTLNFTWQGVGTFPAAERRRLRDIVGAAHARGQRVRFWATPDVAGPARDAVWAELLAAGVDHLNTDDLAGIEAFLDAHRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKB8</accession>
    <name>Q9RKB8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3169</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627385.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975647.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3169"/>
    <dbReference type="GeneID" id="1098603"/>
    <dbReference type="KEGG" id="sco:SCO3169"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3229"/>
    <dbReference type="eggNOG" id="ENOG5031SBM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186185_1_0_11"/>
    <dbReference type="OMA" id="QQGKEQM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="75" mass="9096" checksum="B23638B4D328C89A" modified="2000-05-01" version="1">MGMKDQFQDKAERMQQQGKQRAEQARDQFQNRDRRRDEDEIDPSSPASRRRESEHQDPSSRRRDEDERLQDSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKF3</accession>
    <name>Q9RKF3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3484</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029023.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3484"/>
    <dbReference type="DNASU" id="1098921"/>
    <dbReference type="GeneID" id="1098921"/>
    <dbReference type="KEGG" id="sco:SCO3484"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3543"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_11"/>
    <dbReference type="InParanoid" id="Q9RKF3"/>
    <dbReference type="OMA" id="PIREECT"/>
    <dbReference type="PhylomeDB" id="Q9RKF3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="436" mass="46258" checksum="A0998896BB831621" modified="2000-05-01" version="1">MTKPVVPSGVSRRGFLGGSLGVAGAVLLAACSGGGNSSQGSGGSKFAFWDMPWGSPGPDYLAAGKEISAAFSGGSATYQSISWDGWLQTFSSAIAAGTGPAISTGGAFQSLQYYVQDAVHPADGVIAKLRSKGQLDDFLPGTLDVFKYKGAYTALPWNVDSRLLWYRKSLLEKAGVEEPRSWDDLYRVGVALKKNDVYGMVASGGAGGNAYQTFLSFVFNNGGGLFDKDGEPQCVTDANVEAVEFLMKLAKDGIMDPGSVSYTVANLNDQFSSGAAALSILPPDIANSFEDPRLKADITLGSPLTSPNGTKGTMAYTSDLILYTGDWDTDVVEDFAVYYLDAMSAYWKKGVLNKVPVRQSILDLPEVQAQPNLVKATKEWLPVGKSLTQLAGEPFPEINAVDGGQAITQWAQQVIQAKSSGEQTLRTLQDGIEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKI2</accession>
    <name>Q9RKI2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3450</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627654.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028991.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3450"/>
    <dbReference type="GeneID" id="1098887"/>
    <dbReference type="KEGG" id="sco:SCO3450"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3511"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RKI2"/>
    <dbReference type="OMA" id="PHLTRYA"/>
    <dbReference type="PhylomeDB" id="Q9RKI2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="134"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB61858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="22216" checksum="B3DD9D7D90B194B7" modified="2000-05-01" version="1">MECGSGRGGFRRVEDEVTAPPDSADPRGQAFAAYVLPEVEVLLRVAMTLTAQPADAEDLVQDTLLRAYRAIDRFDGKHPRAWLLTIMRRAEINRHRRRRPHLLDDPDADLDRLSSTGPSGSAEEIVVGEAFDEVVDEALGALPDKHRQVVQLVDIDGLTYAEAAHLLDVPEGTVMSRLHRARKRIRARLATAGLAPKRGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL00</accession>
    <name>Q9RL00_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624645.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027013.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0318"/>
    <dbReference type="GeneID" id="1095742"/>
    <dbReference type="KEGG" id="sco:SCO0318"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.293"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_2_11"/>
    <dbReference type="InParanoid" id="Q9RL00"/>
    <dbReference type="OMA" id="QLWGPRV"/>
    <dbReference type="PhylomeDB" id="Q9RL00"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-keto sterol reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="338" mass="35799" checksum="D90DBA1D4EF37099" modified="2000-05-01" version="1">MGESVLLTSTPPEHKESVIVSSAPQSRPWDVHRLPSAEGRNFLVTGGNAGIGYFTAEQLAATGALVVIGSRNPAKADAALASIRSRVPGARVRHLHLDLADLSTLKSAVDGLALDLGRLDAVVHNAGGALDDPPRRETEDGHELMFGTNHLGHYALTRWLAPLLSAAPAGRVVTVGSFAARSERLDLDDLQSTRDYRPKRTYGRSKLAQMCFGFELDRRLRAAGSTVLSAVAHPGGALDSLTPPRPPVGAPTPGERLRGLPAALMVQGKDAGAWPVVRAVLDSDVQGGQLWGPRVFGLRGQPRREPVPAHMADPAVAARLWAASAELTGTTDPHLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL54</accession>
    <name>Q9RL54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable secreted peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0432</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624753.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027111.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0432"/>
    <dbReference type="GeneID" id="1095855"/>
    <dbReference type="KEGG" id="sco:SCO0432"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.409"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007528_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RL54"/>
    <dbReference type="OMA" id="QRFGWRP"/>
    <dbReference type="PhylomeDB" id="Q9RL54"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017296">
        <property type="entry name" value="Peptidase_S8A_SAM-P45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037852">
        <property type="entry name" value="Subtilisin_rel_SAV5721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176953" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="232"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB56662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1245" mass="130896" checksum="74EE92DB9CA1DE60" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1R1</accession>
    <name>Q9S1R1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37145">
        <property type="entry name" value="T37145"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624562.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978637.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0230"/>
    <dbReference type="GeneID" id="1095654"/>
    <dbReference type="KEGG" id="sco:SCO0230"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.203"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_32_0_11"/>
    <dbReference type="InParanoid" id="Q9S1R1"/>
    <dbReference type="OMA" id="SATCEHI"/>
    <dbReference type="PhylomeDB" id="Q9S1R1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="22414" checksum="51BA45F372EBBF13" modified="2000-05-01" version="1">MPGRPSPLGRRGIERKGDVRERAILDTCEALLADKGYDAMTVGDIAQGAGITRGALYFYFGSKHEVVAALVARTVEHLWERSRVTAQTDEPRQAIAAAMHRTVELWNEHGLVMRTAIDLSLTVPEIGELWSHTADLFIAAITAVLERAGIQSGTAPEQASAMARALCWMIERTFYHASQESREKLQEASATCEHIWLVSAGLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Y5</accession>
    <name>Q9S1Y5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0009</name>
        <name evidence="2" type="ordered locus">SCO7838</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">A3</strain>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37071">
        <property type="entry name" value="T37071"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624370.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631866.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026772.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0009"/>
    <dbReference type="GeneID" id="1095441"/>
    <dbReference type="GeneID" id="1103276"/>
    <dbReference type="KEGG" id="sco:SCO0009"/>
    <dbReference type="KEGG" id="sco:SCO7838"/>
    <dbReference type="HOGENOM" id="CLU_2156856_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC03656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="12621" checksum="29282AE16A1B0446" modified="2000-05-01" version="1">MCGRRPFETQLSECCQLLLGELVPPRPGVRYPYTQFHDYRLHPAVDHDLFAVAARNRPMAFPFDPLCESRETSLESLLRLSRALRRATSCRTGQRCFGGLDTQCGQPLPLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Q7</accession>
    <name>AMPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="1">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucine aminopeptidase</fullName>
            <shortName evidence="1">LAP</shortName>
            <ecNumber evidence="1">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepA</name>
        <name type="ordered locus">SCO2179</name>
        <name type="ORF">SC5F7.22</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="1"/>
    <dbReference type="EC" id="3.4.11.10" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35295">
        <property type="entry name" value="T35295"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626432.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028182.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2Q7"/>
    <dbReference type="SMR" id="Q9S2Q7"/>
    <dbReference type="STRING" id="100226.SCO2179"/>
    <dbReference type="GeneID" id="1097612"/>
    <dbReference type="KEGG" id="sco:SCO2179"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2217"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_11"/>
    <dbReference type="InParanoid" id="Q9S2Q7"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="PhylomeDB" id="Q9S2Q7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000165800" description="Probable cytosol aminopeptidase">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <sequence length="517" mass="51997" checksum="D643F385D3B53CBD" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2X1</accession>
    <name>Q9S2X1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2080</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34950">
        <property type="entry name" value="T34950"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626339.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028129.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2080"/>
    <dbReference type="GeneID" id="1097514"/>
    <dbReference type="KEGG" id="sco:SCO2080"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2113"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2X1"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="PhylomeDB" id="Q9S2X1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB51989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="25257" checksum="0E6B5B8856B25F40" modified="2000-05-01" version="1">MTDRKHELAANLAKVEQRITDACAAAGRPRQDVTLIVVTKTYPADDVRILSELGVRHVAENRDQDAAPKAAACSDLPLSWHFVGQLQTNKVRSVVGYADVVQSVDRARLVTALSKEAVRAGREVGCLLQVALDAEEGGRGERGGVPPAGIEELADLVAGSEGLRLDGLMTVAPLSGEYAGRQQAAFEHLMDLSTRVRRTHPAANMVSAGMSADLEQAVAAGATHVRVGTAVLGVRPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2X6</accession>
    <name>Q9S2X6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2075</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34945">
        <property type="entry name" value="T34945"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626334.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028128.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S2X6"/>
    <dbReference type="STRING" id="100226.SCO2075"/>
    <dbReference type="GeneID" id="1097509"/>
    <dbReference type="KEGG" id="sco:SCO2075"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2107"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2X6"/>
    <dbReference type="OMA" id="RATLCMT"/>
    <dbReference type="PhylomeDB" id="Q9S2X6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB51984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="25225" checksum="CBA8EF69305854D8" modified="2000-05-01" version="1">MVAKKKTTAAKQSAAEESAAEQDPARKKAAEKTAAKKSPARKTAAKKSPAEKTAAKKSTAKKSTAKKVGAAEAAEQTGATTVVAKKTPGTATAAKTAVPKARGTAAVPGDLAVRPGEEPWTPQEVEEARGELQSEADRLRTEIDTSERSLQGMMRDSGDGAGDDEADTGSKNITREHELALAATAREVLSQTERALDRLDAGTYGLCENCGNPIGKARMQAFPRATLCVECKQKQERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8V5</accession>
    <name>Q9X8V5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron-sulphur-binding reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3673</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36608">
        <property type="entry name" value="T36608"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627865.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029156.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3673"/>
    <dbReference type="GeneID" id="1099109"/>
    <dbReference type="KEGG" id="sco:SCO3673"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3732"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X8V5"/>
    <dbReference type="OMA" id="EMHRHKE"/>
    <dbReference type="PhylomeDB" id="Q9X8V5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB44376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="760" mass="83320" checksum="C8D5DCEE8F48DFAD" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W9</accession>
    <name>Q9X8W9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36622">
        <property type="entry name" value="T36622"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627879.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029164.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3687"/>
    <dbReference type="GeneID" id="1099123"/>
    <dbReference type="KEGG" id="sco:SCO3687"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3745"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078525_3_0_11"/>
    <dbReference type="OMA" id="GRTHRMK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="20693" checksum="3BE15607CF4E2148" modified="1999-11-01" version="1">METETQATLAAALAAGYALGRTKKGKVAIGAASVLAGQGLLSPKELLNRALRKAYGSPQAAQLLEQMRGELMGAARSALSATADRRLAALAASLQQRTDSLVSRPGDEAEESSEGTEPDDEEEEGDEEKEREEATGEGEGEEPQVSPRRSRAKKSPAKRSAPRTAPAKKVAAGRKAAGSAPAKKNGASGKASTRGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA01</accession>
    <name>Q9XA01_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3863</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36732">
        <property type="entry name" value="T36732"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628051.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975071.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3863"/>
    <dbReference type="GeneID" id="1099299"/>
    <dbReference type="KEGG" id="sco:SCO3863"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3934"/>
    <dbReference type="eggNOG" id="ENOG502ZRT7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148066_0_0_11"/>
    <dbReference type="OMA" id="SCRHRPL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045925">
        <property type="entry name" value="DUF6344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19871">
        <property type="entry name" value="DUF6344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177035" evidence="2">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="129" mass="13117" checksum="42F73611E559326C" modified="1999-11-01" version="1">MARNKVLTLWTSIVTAFLALCTALGLVTTTAAAAVPQTGTHSNSESASPEAAPAAALPLPRSRTGSLPPTMKQRIRAEAHGAAPSCRHHPLADAAAASAATTAATTTTGLPCDDTAVESRAQHTIPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA49</accession>
    <name>Q9XA49_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3829</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36510">
        <property type="entry name" value="T36510"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628018.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029255.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3829"/>
    <dbReference type="GeneID" id="1099265"/>
    <dbReference type="KEGG" id="sco:SCO3829"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3898"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_11"/>
    <dbReference type="InParanoid" id="Q9XA49"/>
    <dbReference type="OMA" id="PWVHRGE"/>
    <dbReference type="PhylomeDB" id="Q9XA49"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB46952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="491" mass="50552" checksum="CBACD8F118EC637C" modified="1999-11-01" version="1">MAHASDGHVLEFKLPDLGEGLTEAEIVRWLVEVGDVVAVDQPVVEVETAKAMVEVPCPYGGVVTARFGEEGTELPVGAPLVTVTVGGGGAAADGPARDSGTDAGAAGTPVAGTPAAAAAETSPAAETKAEGSGNVLVGYGTSEAPARRRRVRPGRQAATGASGRANGRVRGAGAVDGPVRTAEPADGPVPVISPLVRRLARQHDLDLRELTGSGPDGLILRADVEYALRAAAAQGGRTADPEAGTGRVPDAAPAAVSSAPRSDGTRVPLKGVRGAVADKLSRSRREIPDATCWVDADATELMRARTAMNASGGPKISLVALLARICTAALARFPELNSTVDTDAREVVRLDRVHLGFAAQTDRGLVVPVVRDAHTRDAEALTAEFARLTEAARAGRLTPGELTGGTFTLNNYGVFGVDGSTPIINHPEAAMLGVGRIVPKPWVHEGELAVRQVVQLSLTFDHRVCDGGTAGGFLRYVADCVEQPAVLLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA94</accession>
    <name>Q9XA94_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0831</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36444">
        <property type="entry name" value="T36444"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625131.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978028.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0831"/>
    <dbReference type="GeneID" id="1096254"/>
    <dbReference type="KEGG" id="sco:SCO0831"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.823"/>
    <dbReference type="eggNOG" id="ENOG5033RBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847076_0_0_11"/>
    <dbReference type="OMA" id="YDITHTV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB48908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="306" mass="34206" checksum="006E650DAC0ABB6A" modified="1999-11-01" version="1">MTDTRLIHRVGADALEWLWAHRDGFRLEPDVDPEIGFLERFKPIGELALICTVLFREGVAGSRQAQLARQLLDHTWRETLDGGRMLVRAQRVEPFSPVPFEVYLPFKELGHSQPEIEHATVLNHRLDSWARLPVTPTRRLGLSAFQRRFGLTARPPEADLVPSTWLAGTPEPWTVEGHTAYDITHTVFHLTDWGENPGGLPPGVADYLATWLPVWIDDWLDLQRWDLLGELLVVDACLPRPALDEAAWRGFAAAQQPDGAMPAVRTMPEGDPDTVFDVVYHPTLVAAFASLLATSRALAELAHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAB1</accession>
    <name>Q9XAB1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative rhamnose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0814</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36427">
        <property type="entry name" value="T36427"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978046.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0814"/>
    <dbReference type="GeneID" id="1096237"/>
    <dbReference type="KEGG" id="sco:SCO0814"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.806"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_11"/>
    <dbReference type="InParanoid" id="Q9XAB1"/>
    <dbReference type="OMA" id="MPDLFNY"/>
    <dbReference type="PhylomeDB" id="Q9XAB1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="71"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="255"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB48891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="484" mass="51117" checksum="15928DABC49FE469" modified="1999-11-01" version="1">MSTAIDTKAFAAVDLGASSGRVMVGRVGADRLELTEAHRFPNRPVRTPDGLRWDVLALYAGVLDGLRAAGRVDSVGVDSWAVDHGLLDADGVLLGNPVHYRDARTEGVAERVWASLPAGELYAATGLQYAPFNTLYQLVAARGTAQFAAARRLLLIPDLLTYWLTGEQGTELTNASTTQLIDPRTRDWSREVADRLGIDLGLFAPLRRPGDPAGLLRPEVLEETGLAGPVPVTAVGSHDTASAVAAVPASGERFAYICTGTWSLAGLELSAPVLTQESRAANFTNELGLDGTVRYLRNIMGLWLLQESVRAWGDPDLGELLLAAARVPALRSVVDAGDAGFLAPGRMPERIAEACRASGQPVPETPAEVTRCILDSLALAHRAAVGEAQRLAGHPVDVVHVVGGGTRNALLCQLTADACGLPVVAGPTEAAALGNVLVQARAHGLVGDLAGMRRLVARTQSLTRYEPRGDPARWQAAAARLAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAD2</accession>
    <name>Q9XAD2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1924</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35996">
        <property type="entry name" value="T35996"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626189.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976895.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1924"/>
    <dbReference type="GeneID" id="1097358"/>
    <dbReference type="KEGG" id="sco:SCO1924"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1950"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_6_0_11"/>
    <dbReference type="InParanoid" id="Q9XAD2"/>
    <dbReference type="OMA" id="HAVWIGD"/>
    <dbReference type="PhylomeDB" id="Q9XAD2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB50749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="394" mass="41807" checksum="55AA82B7D75BDBD9" modified="1999-11-01" version="1">MAEAQNIPVGSTTAGQIAVAAESTVATRMSAPASFDVADFPVPHGREEEWRFTPLERLRGLHDGTAVATGDGVKVDVEAPEGVVVETVGRDDARIGRAGTPVDRVAAQAYSAFEKAGVITVPKETVLTEPIRIAVHGEGGTAYAHQVVELGAFAEAVVVIDHTGDAVLAANVDYVLGDGAKLTVVSVQDWDDKAVHVGQHNALVGRDATFKSFVVTFGGDLVRLHPRVAYAGPGGEAELFGLYFTDAGQHQEHRLLVDHNVPHCKSNAVYKGALQGDDAHAVWIGDVLIEAAAEGTDTYEMNRNLVLTDGARVDSVPNLEIETGEIVGAGHASATGRFDDEQLFYLMARGIPELDARRLVVHGFFAELVQQIGVADIEERLLAKIAQELEASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z550</accession>
    <name>Q9Z550_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6122</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35905">
        <property type="entry name" value="T35905"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630228.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030667.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6122"/>
    <dbReference type="TCDB" id="9.B.15.2.2">
        <property type="family name" value="the 4 tms ybhq (ybhq) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101563"/>
    <dbReference type="KEGG" id="sco:SCO6122"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6225"/>
    <dbReference type="eggNOG" id="ENOG50330Y1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111152_1_3_11"/>
    <dbReference type="OMA" id="ENRPADW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="16230" checksum="A52D458B9448E1D3" modified="1999-05-01" version="1">MLNALEVFTTVIVGLMVGVEFSVAFVMNRIFNALPEDSGQLARAHGGRMLGALMPFWYIGSLVLSAVWAVAGWDRSGAGLVVIAAALLIVSVIMSLLLLVPINDRGKTWTPENRPADWKEQMNRWDRYHYVRVAVIVAAFACLVTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBF1</accession>
    <name>Q9ZBF1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6462</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35949">
        <property type="entry name" value="T35949"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630547.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030939.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6462"/>
    <dbReference type="GeneID" id="1101901"/>
    <dbReference type="KEGG" id="sco:SCO6462"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6562"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBF1"/>
    <dbReference type="OMA" id="INNPKSC"/>
    <dbReference type="PhylomeDB" id="Q9ZBF1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA22771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17929" checksum="F87FEC98AABB20FD" modified="1999-05-01" version="1">MKQHTVIDSPYGALTLVAEDGALCGLYMTDQRHRPDEETFGARDERPFAETEEQLEAYFSGELKDFTLGLRLNGTPFQRMVWTQLRKIPYGETRSYGELAAALGNPAASRAVGLANGRNPIGIIVPCHRVIGASGGLTGYGGGLERKQRLLDFERGTAVPEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBG8</accession>
    <name>Q9ZBG8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6445</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35932">
        <property type="entry name" value="T35932"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972533.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6445"/>
    <dbReference type="GeneID" id="1101884"/>
    <dbReference type="KEGG" id="sco:SCO6445"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6545"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_6_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBG8"/>
    <dbReference type="OMA" id="EDFLMEQ"/>
    <dbReference type="PhylomeDB" id="Q9ZBG8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA22754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="30072" checksum="4AB69DF313F847E7" modified="1999-05-01" version="1">MIEDNETIDEFLARHTGDVEEAVRKAAAQEIMPRWRRLAAHEVDQKAGPHDLVTDADRKAELYLTEVLPRLLPGSVVVGEEAVHANPASYGAIRGEAPVWIVDPVDGTRQFVRGEEGFCTLVALAHRGVVHASWTYAPAGDRLATAARGGGAFLDGERLYAGPPEPGRDLRVATSHPDYTTDEQKRDLLALRTPGVAPRPCGSAGLEYLAVARGESDATAFSWEAAWDHAAGLLLVEEAGGTHLTRTGEPFRITGGNELPFTAARDAATARQVVALLSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O50512</accession>
    <name>O50512_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5838</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35874">
        <property type="entry name" value="T35874"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629961.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030488.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5838"/>
    <dbReference type="GeneID" id="1101280"/>
    <dbReference type="KEGG" id="sco:SCO5838"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5935"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_11"/>
    <dbReference type="InParanoid" id="O50512"/>
    <dbReference type="OMA" id="WAFPAPE"/>
    <dbReference type="PhylomeDB" id="O50512"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="39"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="191"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA15795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="462" mass="48910" checksum="4A28CB7E7E4CC660" modified="1998-06-01" version="1">MTELATMEFHAQPQAGEPKPWAFPAPERGSLDNGLTVLRCHRPGQQVVAVEVLLDAPLDAEPAGLDGVATIMARAFSEGTDKHSAEDFAAELERCGATLDAHADHPGVRLSLEVPASRLGKALGLLADALRAPAFADGEVERLVRNRLDEIPHELANPSRRAAKELSKELFPADARMSRPRQGTEETVETIDSAAVRAFYERHVRPATATAVVVGDLTGVDLDALLADTLGAWTGSAAEPRPVPPVTADDRGRVVIVDRPGAVQTQLLIGRTGADRHDRVWPAQVLGTYCLGGTLTSRLDRVLREEKGYTYGVRAFGQVLRSAPDGTGAAMLAISGSVDTPNTGPALEDLWTVLRKLAAEGLTDAERDVAVQNLVGVAPLKYETAAAVASTLADQVEQHLPDDFQATLYRQLAATGTVEATAAVVNAFPVDRLVTVLVGDAAQIKEPVEALGIGEVTVVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O50513</accession>
    <name>O50513_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5839</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35875">
        <property type="entry name" value="T35875"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629962.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030489.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5839"/>
    <dbReference type="GeneID" id="1101281"/>
    <dbReference type="KEGG" id="sco:SCO5839"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5936"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_12_0_11"/>
    <dbReference type="InParanoid" id="O50513"/>
    <dbReference type="OMA" id="DGTYTQY"/>
    <dbReference type="PhylomeDB" id="O50513"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174829" evidence="2">
        <location>
            <begin position="45"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="142"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="25787" checksum="869D212ECF2AE29F" modified="1998-06-01" version="1">MAFTRATGKHRRPGRVHRTTVRAAGVAALATTGVVGTLAAPALAAEPEAEQTGLTPVVTIGDSIADEIDAQALAQKQAAADAAAREAARERAAEAAKEAREAKERAAREAERERLNTFVAPITASYVSTAYQAGSSLWSSGSHTGIDFHASSGTSVHSVGVGTVVEAGWGGAYGNQVVIRMHDGTYTQYGHLSSIGVSVGQSVEPGQQIGVSGATGNVTGPHLHFEARTSPEYGSDMDPVAYLRSHGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O50530</accession>
    <name>O50530_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5856</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35892">
        <property type="entry name" value="T35892"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629979.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030500.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5856"/>
    <dbReference type="GeneID" id="1101298"/>
    <dbReference type="KEGG" id="sco:SCO5856"/>
    <dbReference type="eggNOG" id="ENOG5032Y91">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046283_1_0_11"/>
    <dbReference type="OMA" id="SKHTAMI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA15813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="28497" checksum="1BD03D0C0891512C" modified="1998-06-01" version="1">MRERSDDAGVADVGSKGESRRIDLSVPQVAGSALAAVVAAKLASSFGVYGTIAGAGLISVVATCGGSVLQHFFKRTGEQIRVKRTVAAVRIDGRTASVPAATPDPNPASASGDFTEGTVYRTRTRGWRRPLVAAALVFGVTMAGITVYEVASGQNLSGGHSTTVGSAFTGHGKSAADSGESGESGDSGGTEDPQDGRDSGDSGDANDSGSGSEAPAPTPSGSPDATDGSPSSGAGSTEGGGTESSPTPTRDAGGDEEAGGTGAPDPDASATAPEPGASSRSGTGGQGQDGPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O69907</accession>
    <name>O69907_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5619</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34804">
        <property type="entry name" value="T34804"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629753.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030345.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5619"/>
    <dbReference type="GeneID" id="1101060"/>
    <dbReference type="KEGG" id="sco:SCO5619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5708"/>
    <dbReference type="eggNOG" id="ENOG5031KYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585508_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="17934" checksum="72063B195040BD6E" modified="1998-08-01" version="1">MAAKKTETAEATPCECSMYDALPADLTEEQVASGDFEVLTTGCTATTKRQFAPGHDAKLKSALIRWGALGLEIRRNEGGVATSASPAKHAARYAFAHMVTAGVKRAEAKAAEKAERAAARAAKKAAPAPEVIKAKVGRVTYQGRMDGDHFVYEVKGQERRTLKFQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="157" xmlns="http://uniprot.org/uniprot">
    <accession>O69998</accession>
    <name>O69998_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5822</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35196">
        <property type="entry name" value="T35196"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629945.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973199.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5822"/>
    <dbReference type="GeneID" id="1101264"/>
    <dbReference type="KEGG" id="sco:SCO5822"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5919"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_11"/>
    <dbReference type="InParanoid" id="O69998"/>
    <dbReference type="OMA" id="DKLMEFQ"/>
    <dbReference type="PhylomeDB" id="O69998"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="480"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA18520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="707" mass="77270" checksum="1A5427EB8EFB6661" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O86627</accession>
    <name>O86627_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6358</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29451">
        <property type="entry name" value="T29451"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030855.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6358"/>
    <dbReference type="GeneID" id="1101799"/>
    <dbReference type="KEGG" id="sco:SCO6358"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6470"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_1_1_11"/>
    <dbReference type="InParanoid" id="O86627"/>
    <dbReference type="OMA" id="HTELDRD"/>
    <dbReference type="PhylomeDB" id="O86627"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="129" mass="14305" checksum="DB7D51F5D0F75C21" modified="1998-11-01" version="1">MTEARDKTDARDERRPAGELEAAVMAALWAAGAPLTPGRVQTELGSGLARTTVATILTRLHEKGVVDRERQGRGYAYFPVQDAPGLTARRMHTELDRDTDRETVLARFVAQLGPGDEQHLRRLLEGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O86766</accession>
    <name>O86766_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TraSA:integrase fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5633</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35465">
        <property type="entry name" value="T35465"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629765.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5633"/>
    <dbReference type="GeneID" id="1101073"/>
    <dbReference type="KEGG" id="sco:SCO5633"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5721"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_363662_0_0_11"/>
    <dbReference type="PhylomeDB" id="O86766"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="163"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="440"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="544"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA19919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="768" mass="84366" checksum="A31267CA1D308194" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O86775</accession>
    <name>RL17_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">SCO4730</name>
        <name type="ORF">SC6G4.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35559">
        <property type="entry name" value="T35559"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628888.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974243.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86775"/>
    <dbReference type="SMR" id="O86775"/>
    <dbReference type="STRING" id="100226.SCO4730"/>
    <dbReference type="GeneID" id="1100171"/>
    <dbReference type="KEGG" id="sco:SCO4730"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4801"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_0_11"/>
    <dbReference type="InParanoid" id="O86775"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="PhylomeDB" id="O86775"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000175543" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="168" mass="18131" checksum="3C25C584F4C9462E" modified="1998-11-01" version="1">MPKPSKGARLGGSAAHEKLLLANLAKSLFEHGRITTTEAKARKLRPYAERLVTKAKKGDLHNRRQVLQVITDKSIVHTLFTEIGPRYENRPGGYTRITKIGNRRGDNAPMAVIELVEALTVAQQATGEAEAATKRAAKDAEGSAEVSEAKVDTTKADDEAAAEESKDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O86840</accession>
    <name>THYX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name type="ordered locus">SCO5743</name>
        <name type="ORF">SC9A10.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35843">
        <property type="entry name" value="T35843"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629868.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86840"/>
    <dbReference type="SMR" id="O86840"/>
    <dbReference type="STRING" id="100226.SCO5743"/>
    <dbReference type="GeneID" id="1101182"/>
    <dbReference type="KEGG" id="sco:SCO5743"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5831"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067790_0_0_11"/>
    <dbReference type="InParanoid" id="O86840"/>
    <dbReference type="OMA" id="EWARLMP"/>
    <dbReference type="PhylomeDB" id="O86840"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175577" description="Flavin-dependent thymidylate synthase">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ThyX" evidence="2">
        <location>
            <begin position="17"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="ThyX motif" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00661"/>
        </source>
    </evidence>
    <sequence length="246" mass="27785" checksum="9F1A003121485EB2" modified="1998-11-01" version="1">MTDIPADDPKIELRSDITVELVKSAATDSDVLFAARVSTAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQPVFYAPDASRKLVQQGRPGKYVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLPVGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAFNANGRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O88008</accession>
    <name>O88008_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35151">
        <property type="entry name" value="T35151"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031078.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6652"/>
    <dbReference type="GeneID" id="1102091"/>
    <dbReference type="KEGG" id="sco:SCO6652"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6757"/>
    <dbReference type="eggNOG" id="COG2263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047561_1_0_11"/>
    <dbReference type="OMA" id="EAFNDHQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="461" mass="47141" checksum="BCD336CCF686756E" modified="1998-11-01" version="1">MNTSRPAPPTERTVPSPAESAVPASTESAVLARTGGAVPAPAESVGPSPAGGTGPVRLGPPDATGSRIAVVPVSGPARSDAGRPVERPASGLGGGPGEGRALPSADRAEGGAARPATQRPGGADERTEDRAEQPSAGPVAEGQGQGRFGAGRPSAGSVADGLEQSSGERATVRLRGAPVREHPAEPPRYAPEWLRLREPADAAARAHDLLDPLRIRLADLPGRADGLVVHDLGCGTGSMGRWLAPLLDGAQHWVLHDRDPYLLHFAAAGAPHTAADGSRVTVETRRGDLAHLTPDALNGAGLVTASALLDVLTTEEVGKLAAACTAAGCPALLTLSVAGRVDLTPGHPLDTEITEAFNDHQRRTGMLGPGAVTVATEAFAGHGATVRAQPSDWRLGPGEAGLTAQWLRGWVGAAVEQRPELRARADRYLEERLAACAAGELRVVVHHTDLLALCRPTGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKI7</accession>
    <name>Q7AKI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase complex B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42208">
        <property type="entry name" value="T42208"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629079.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029952.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKI7"/>
    <dbReference type="STRING" id="100226.SCO4926"/>
    <dbReference type="GeneID" id="1100367"/>
    <dbReference type="KEGG" id="sco:SCO4926"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5005"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_11"/>
    <dbReference type="InParanoid" id="Q7AKI7"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="PhylomeDB" id="Q7AKI7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="57159" checksum="3CD6380087CFA431" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKK7</accession>
    <name>Q7AKK7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4011</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628193.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974952.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4011"/>
    <dbReference type="GeneID" id="1099447"/>
    <dbReference type="KEGG" id="sco:SCO4011"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4074"/>
    <dbReference type="eggNOG" id="ENOG5030PCJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843968_0_0_11"/>
    <dbReference type="OMA" id="RCREMPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046201">
        <property type="entry name" value="DUF6234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19747">
        <property type="entry name" value="DUF6234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="157" mass="15743" checksum="A8464A779F1938EF" modified="2004-07-05" version="1">MCPFRVRARVADMDLPVAPPAFDATTGSGRRRRADLGADIGAGCGLVVLELIALVVVLGLWFLSGFNLDPAESAAPDPLWNYVAAVGGVGAFAGVAAAVAARAGAVVTVVGQAVVVGLVCAVVFGGVALQSHQDQRCREMPAATGCTGSGRGGSPLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX6</accession>
    <name>GLMU_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name type="ordered locus">SCO3122</name>
        <name type="ORF">SCE41.31</name>
        <name type="ORF">SCE66.01</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="1"/>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733593.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975692.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8CJX6"/>
    <dbReference type="SMR" id="Q8CJX6"/>
    <dbReference type="STRING" id="100226.SCO3122"/>
    <dbReference type="GeneID" id="1098556"/>
    <dbReference type="KEGG" id="sco:SCO3122"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3186"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_11"/>
    <dbReference type="InParanoid" id="Q8CJX6"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="PhylomeDB" id="Q8CJX6"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000233860" description="Bifunctional protein GlmU">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="260"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="394"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="482" mass="49796" checksum="7443E7BDB2B6347B" modified="2003-03-01" version="1">MSAIRPAAVVVLAAGEGTRMKSATPKVLHELCGRSLVGHVLAAAGELDPENLVAVVGHAREKVTAHLAEVAPDVRTAVQEQQNGTGHAVRMGLEAMGGAVDGVVVVVCGDTPLLTGETLKALAATHTADGNAVTVLTAEVPDATGYGRIVRDGASGAVTAIVEHKDASESQRAIREINSGVFAFDGQLLADALGKVRTDNSQGEEYLTDVLGILREAGHRVGASVAGDHREIAGINNRVQLAEARRILNDRLLTGAMLAGVTVVDPATTWVDVTVTFEQDVVVHPGTQLHGTTHLAEGCEVGPNTRLTDTRVEAGARVDNTVANGAHVGPQASVGPYAYLRPGTRLGLKSKIGTFVEAKNSSIGEGTKVPHLSYMGDATVGDFTNIGAASVFVNYDGQDKHHTTIGSHCRTGSDNMFVAPVTVGDGAYTAAGSVITKDVPPGSLAVARGQQRNIEGWVARKRPGSAAAKAAEAVSREADGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IV5</accession>
    <name>Q93IV5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative siderophore binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1315</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625601.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977514.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1315"/>
    <dbReference type="GeneID" id="1096738"/>
    <dbReference type="KEGG" id="sco:SCO1315"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1318"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_4_0_11"/>
    <dbReference type="InParanoid" id="Q93IV5"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="PhylomeDB" id="Q93IV5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="18100" checksum="5DE922BB7F4A4394" modified="2001-12-01" version="1">MTQKALITGIGGKDPKVDAEVFVAPTASVVGDVTLHAGASVWYGAVLRGDVERISVGADSNVQDNCTLHADPGFPVTVGERVSIGHNAVVHGATVEDDCLIGMGATVLNGAVIGAGSLVAAQALVPQGMRVPPGSLVAGVPAKVKRELTEEERQGVTLNGTMYAALAGQHRDAVGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J79</accession>
    <name>Q93J79_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2818</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627047.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028602.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2818"/>
    <dbReference type="GeneID" id="1098252"/>
    <dbReference type="KEGG" id="sco:SCO2818"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2876"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038711_1_0_11"/>
    <dbReference type="InParanoid" id="Q93J79"/>
    <dbReference type="OMA" id="DGKGDWD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004320042" evidence="1">
        <location>
            <begin position="41"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="436" mass="47133" checksum="852D77C0489C2EF6" modified="2001-12-01" version="1">MHKLGAVSRQPRPEVHVPRQLPRTRLRSTAAVCTTMSALAATSLITAPSVAEPFSPEPCALQRTAVHHSEGLDTWNATYPRPARTLDAVMVFLSFPDSQPLTAPAELAADHFPATGDFFRRASYGAFTLRPHPLRDWIRMPSPSTSYAIRRDWSPEHRAAYLRDALTAADRYVDFSRYDVVYFVADPDAPGVDSDATKVVNLDTPLRADGTDIRRVVTVFENHPPDRLVLAHETGHVFDLPDLYHRPADGEGDWDTHVGDWDLMGSQFGLSPDLFGWHKWKLGWLRPRQVACVRGSEPTRLTLEPLGAGPGVVVTGAAGAPAFGLGRGTKLAVVRTGAGSALAFEVRTPVGNDAASCRAGVLVYRVHSGAESGGGPIEVVDAHPDTEACWADSVYPPLADAPVSLGESFTVPGDGVRVEVEDRTESGTWTVQITPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J83</accession>
    <name>Q93J83_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2814</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627043.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975986.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2814"/>
    <dbReference type="GeneID" id="1098248"/>
    <dbReference type="KEGG" id="sco:SCO2814"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2872"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_5_11"/>
    <dbReference type="InParanoid" id="Q93J83"/>
    <dbReference type="OMA" id="GVMFFED"/>
    <dbReference type="PhylomeDB" id="Q93J83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="29897" checksum="A8B64AB626949E23" modified="2001-12-01" version="1">MPDIVNTEQAQAWNGPEGAHWARNQDRWNAVNEGFDEPLLDAAGITGEDRVLDLGCGSGQTTRRAALRAPRGHVLGLDLSGPMLAEARSRAEREGVANVSFAQGDAQVHPFGAGAFDAAVSRYGVMFFADPVAAFGNVGRALRPGGRLAFVCPADAALNGWVTAMASLREVLPVGDFGQPGLPGMFSLAAPDRIGDVLTAAGFAGIDVNQVQAHGTWGRDAEDAAEFLLGTGPGRHLMERADPTARARARGILTDHLRTHEAADGTVRLLSTSWLTTATRPAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JG2</accession>
    <name>Q93JG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7710</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC44566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631748.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031845.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7710"/>
    <dbReference type="GeneID" id="1103148"/>
    <dbReference type="KEGG" id="sco:SCO7710"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7830"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127198_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JG2"/>
    <dbReference type="OMA" id="VLWRKPP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="26535" checksum="AF7111CED87E9F3B" modified="2001-12-01" version="1">MDEVEVVVAHSERATLRVGDVFLKVDADQARIDAEIEAMSRVPVPTPQVLWHQPPVLAITALPGTTLGRLGGPSTGSPAGWAAAGAAIRKLHDAPLPPWRGRAGRSVAALAAELDDECASLVTNGVLPADLVTRNRRVAEAALRPWTAAFTHGDLQIAHVFVDGDEVTGIIDWSEAGQGDPLYDLATFTLGHEEHLGDVIAGYGADIDIDVIHAWWSLRSLLAVRWLSEHGFDPFAPGCEVDVLRSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK1</accession>
    <name>Q93JK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative metal ion transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4993</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629145.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029990.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4993"/>
    <dbReference type="TCDB" id="2.A.55.3.4">
        <property type="family name" value="the metal ion (mn(2+)-iron) transporter (nramp) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1100434"/>
    <dbReference type="KEGG" id="sco:SCO4993"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5074"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_6_3_11"/>
    <dbReference type="InParanoid" id="Q93JK1"/>
    <dbReference type="OMA" id="MCMFGTT"/>
    <dbReference type="PhylomeDB" id="Q93JK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC40606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="456" mass="49882" checksum="60D4ADCBC8C0474A" modified="2001-12-01" version="1">MHALLSHRRPWAFLTPMADTTGNTSDAGVSVGADQAPRKSSWRYIGPGIVVAATGVGAGDLVATLIAGSNFGYTLLWAAVIGCLVKISLAEACGRWHLATGRTLFDGWASIGSWTTWFFAIYAVIWGFVYGAAAMSSSALPLQALFPDVMDLEWWGIACGLVGLVFVWFNKYNVFEKVMTVLVGVMFVITVYLAIRVTPNLGDAFAGLLPVLPDEKDSVLNTLGLIGGVGGTITLAAYGYWVNAKGWTTTGWMKVMRLDNRVAYATTGIFVVAMLLVGAELLHSANIAIASGDKGLIQLGDILEQEYGTATGKLFLIGFFATSFTSLIGVWHGVSLMFADFLARRRGEREARGDELASGRRERSWAFRAYLLWLTFPPMILLFQDEPFRLIIIYGVLGAAFMPFLALTLMWLLNSSRTPREWRNGSLSNGMLAMAGLLFLVLCVKQIWDQPWSEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RY4</accession>
    <name>Q93RY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6288</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630386.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972637.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6288"/>
    <dbReference type="GeneID" id="1101729"/>
    <dbReference type="KEGG" id="sco:SCO6288"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6403"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_0_1_11"/>
    <dbReference type="InParanoid" id="Q93RY4"/>
    <dbReference type="OMA" id="WFHGRLI"/>
    <dbReference type="PhylomeDB" id="Q93RY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC37890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="276" mass="30952" checksum="239CAB4986065C88" modified="2001-12-01" version="1">MGPFEIVGDDGRVHLPTTPKVCQTLALLLTRPNEIVAADSVIQELWGDDPPRSAHATVQTYIHQARRMFRDRRLTDDERRPLATHAPGYLIRVADEEVDSTVFQRLVDRSRTELDQGRPQSAADSARTALALWRGPVLSNVPVGRALTARVVHLEEVRIRALELALEADRRLGRERGSIPELRSLVHDFPLNEWFHGRLIRALHRAGRRAEALEAYQCLYRILDTELGLEPSPEIQRLQSEVLDPPPGIGPSLLGSDDLLAPYDGHRDRVGAPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q93S05</accession>
    <name>Q93S05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6284</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630382.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972641.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6284"/>
    <dbReference type="GeneID" id="1101725"/>
    <dbReference type="KEGG" id="sco:SCO6284"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6400"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_11"/>
    <dbReference type="InParanoid" id="Q93S05"/>
    <dbReference type="OMA" id="FICGPEV"/>
    <dbReference type="PhylomeDB" id="Q93S05"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="277"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC37885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="57334" checksum="E25F52E1D9035D40" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACZ1</accession>
    <name>Q9ACZ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCP1.160c</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="15">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639733.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039459.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095238"/>
    <dbReference type="KEGG" id="sco:SCP1.160c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8106"/>
    <dbReference type="HOGENOM" id="CLU_014881_0_0_11"/>
    <dbReference type="OMA" id="RGACHHP"/>
    <dbReference type="PhylomeDB" id="Q9ACZ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC36681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="525" mass="54871" checksum="66419213D9D875BE" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD78</accession>
    <name>Q9AD78_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4931</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629084.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029957.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4931"/>
    <dbReference type="GeneID" id="1100372"/>
    <dbReference type="KEGG" id="sco:SCO4931"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5010"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037940_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AD78"/>
    <dbReference type="OMA" id="YCHQRVA"/>
    <dbReference type="PhylomeDB" id="Q9AD78"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="204"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="366" mass="39322" checksum="6BF6F19C6DC971DB" modified="2001-06-01" version="1">MAAAHSAREAWRAAAVGGCLALGGSFAALSVWERELGRLRVLVNVGRRAEDEEEFPEDESYPVHQFAEITEFLHERWAGGGEPDAWVETARGPAAGRPGYVHQRVAALRRRGRGCCVVAPIVLHGRAWGELYVARPVGERVFERGDADFATVLASVVAAGIAQTERLEEVRRLAYTDALTGLANRRAVDAALDEAVERHREEDVVVSLVVCDLNGLKRVNDTHGHAVGDRLLERFGSVLSLCGAMLPGALAARLGGDEFCLLAVGPPADAVVKAAEELCRRAAELELGDGVACGVASTEDPVGPVRSARRLFRLADAAQYRAKAERAAGPVVAGREGPDDPVVRLADEPSRAEDGERRRFRGRHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD96</accession>
    <name>Q9AD96_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1671</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC36374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625946.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027909.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1671"/>
    <dbReference type="GeneID" id="1097102"/>
    <dbReference type="KEGG" id="sco:SCO1671"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1688"/>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007524_2_1_11"/>
    <dbReference type="OMA" id="LRHGWAV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_4" evidence="3">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD_C_2" evidence="2">
        <location>
            <begin position="689"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="772" mass="78150" checksum="F53A8690531787FF" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-04-16" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADB2</accession>
    <name>KHSE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine kinase</fullName>
            <shortName evidence="1">HK</shortName>
            <shortName evidence="1">HSK</shortName>
            <ecNumber evidence="1">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrB</name>
        <name type="ordered locus">SCO5356</name>
        <name type="ORF">SCBAC5H2.25</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="1"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629496.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030204.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ADB2"/>
    <dbReference type="SMR" id="Q9ADB2"/>
    <dbReference type="STRING" id="100226.SCO5356"/>
    <dbReference type="GeneID" id="1100796"/>
    <dbReference type="KEGG" id="sco:SCO5356"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5436"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_1_11"/>
    <dbReference type="InParanoid" id="Q9ADB2"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="PhylomeDB" id="Q9ADB2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0791">Threonine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156617" description="Homoserine kinase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <sequence length="309" mass="31820" checksum="0FB4932009555839" modified="2001-06-01" version="1">MAGPAFRAAAVRVRVPATSANLGPGFDALGLALGLYDDVVVRVADSGLHIDIAGEGSETLPRDEKHLLVRSLRTAFDLLGGQPRGLEIVCANRIPHGRGLGSSSAAICAGIVAARAVTIGGEARLDDAALLDLATEIEGHPDNVAACLLGGFTLSWMESGAARAIRMEPSDSIVPVVFVPGKPVLTQTARGLLPRSVPHVDAAANAGRAALLVEALTRRPELLLPATEDRLHQEYRAPAMPESTALVERLRGDGIPAVISGAGPTVMALADADTADKVEALAGTDWAANRLGLDQQGATVLPLATASDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADD7</accession>
    <name>Q9ADD7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629225.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973904.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5074"/>
    <dbReference type="GeneID" id="1100515"/>
    <dbReference type="KEGG" id="sco:SCO5074"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5153"/>
    <dbReference type="eggNOG" id="ENOG5033N7K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288257_0_0_11"/>
    <dbReference type="OMA" id="CYPDPNP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176608" evidence="1">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="23134" checksum="9B74022F613B8F72" modified="2001-06-01" version="1">MTSSLHHAIRLTTASAIALGGLVTLGTSAHAASVAVPYECRTWVQGNTHPVYDYARGFDVSVPASVRAGKKFKATYDPDPITAFAEYNQIVNDVRIAYRIPDGAKVHKVRLTGGSGLGDSDVRVQVKGRDIVVSASGPFQGGVEFDLPTLKVTYKAPKTTGPLNFVSGGSGYEDPGFYWYRYQPILDEWGPFECFPDPAKPEAVLASTQVKKHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK82</accession>
    <name>DPO4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase IV</fullName>
            <shortName evidence="1">Pol IV</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dinB</name>
        <name type="ordered locus">SCO1380</name>
        <name type="ORF">SC10A9.22c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAC32304" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32304.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625664.2">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027755.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9AK82"/>
    <dbReference type="SMR" id="Q9AK82"/>
    <dbReference type="STRING" id="100226.SCO1380"/>
    <dbReference type="GeneID" id="1096803"/>
    <dbReference type="KEGG" id="sco:SCO1380"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1388"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_0_11"/>
    <dbReference type="InParanoid" id="Q9AK82"/>
    <dbReference type="PhylomeDB" id="Q9AK82"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0515">Mutator protein</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173953" description="DNA polymerase IV">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="479" mass="50700" checksum="6F711DA31198AFEB" modified="2002-08-02" version="2">MRTAPTILHLDMDAFFASVEQASKPSLRGKAVVVGGLGPRGVVATCSYEARVFGVHSAMPMGQARRLAPHAAYLVPRFELYRSISEQVMRLLRELSPLVEPLSLDEAFVDLDAGGAARDAETARLAGTKLRTDIRTVTGLTGSVGLAASKMLAKIASEAAKPDGLVLIPPGTERAMLEPMTVRTLPGVGPATGDHLRRAGITTVGEIAEAGEDELVRLLGKAHGHALYAMALARDERPVVAERETKSVSVEDTYDVDIHDRVRVGVEVGRLADRCVRRLRASGLSGRTIVLKVRRYDFSTLTRSETLRGPTDDPAVVREAAARLLDSVDTTGGVRLLGVGVSGLADYTQEDLFAQAAGDRAEEPAEEPGTEPAEAHSPSPAERRWPSGHDVRHTELGHGWVQGSGLGRVTVRFETPYSGVGRVRTFLVDDPELTPADPLPLVADTEGGAGQPSSGPLPLPASLPKSWSGGGGAAATSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK91</accession>
    <name>Q9AK91_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1371</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625655.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027752.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9AK91"/>
    <dbReference type="STRING" id="100226.SCO1371"/>
    <dbReference type="GeneID" id="1096794"/>
    <dbReference type="KEGG" id="sco:SCO1371"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1379"/>
    <dbReference type="eggNOG" id="COG0384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_2_1_11"/>
    <dbReference type="InParanoid" id="Q9AK91"/>
    <dbReference type="OMA" id="DWALRWF"/>
    <dbReference type="PhylomeDB" id="Q9AK91"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="28477" checksum="910B32AA778EC989" modified="2001-06-01" version="1">MRIRIVDAFTDRPFAGNPAGVLLLDAFPDDDRLQRVALEVNHSETAFAHRLPAGGEADWALRWFTPATEVAMCGHATLATAHVLHTTGAHEGPVRFATRSGVLVATPREDGSFTLDFPTAPLTPVEAPPGIAAALGAEPRTVLDTGPNIGDLLVEVADEETVRGLSPDLGALAAHSERGIIATARAEDPARGYDYVSRCFFPNVGIDEDPVTGSAHTALAPFWSERLGRPDLIGLQASSRSGRVRTELRGGRTLLSGHAVTVIDGELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWH9</accession>
    <name>Q9EWH9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO2995</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC18732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627218.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975816.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2995"/>
    <dbReference type="GeneID" id="1098428"/>
    <dbReference type="KEGG" id="sco:SCO2995"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3054"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_4_0_11"/>
    <dbReference type="InParanoid" id="Q9EWH9"/>
    <dbReference type="OMA" id="ELNPLYH"/>
    <dbReference type="PhylomeDB" id="Q9EWH9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="72"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC18732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="34410" checksum="1D6CF69197133A2D" modified="2001-03-01" version="1">MSQVLDPPPPTRASTQAAPFTTESGPAAGSDLAALAARHGLTVSGARPSLPQYVRDLWARRHFIGAFSTAKLTAQYSQAKLGQLWQVMTPLLNAAVYYFIFGLLMDTKRGVEDFVPFLVTGVFVWTFTQSSIMAGTRAISGNLGLVRALHFPRAALPVSFCLQQLQQLLFSMAALLVILLAFGVPPAPSWVLALPALVLQFLFNAGVAMVMARVGSKIPDMAQLMPFLLRTWMYASGVMFSIEHMTGPDSGLPSWVGTALQLNPAVVYIDLMRFALIDTFGGSQLPPHVWALAVGWALVAGIGGFVYFWKAEETYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWK5</accession>
    <name>Q9EWK5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7788</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031911.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7788"/>
    <dbReference type="GeneID" id="1103225"/>
    <dbReference type="KEGG" id="sco:SCO7788"/>
    <dbReference type="eggNOG" id="ENOG5031VA8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206668_0_0_11"/>
    <dbReference type="OMA" id="MTTRCGA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="65" mass="6990" checksum="AD83904FF2652857" modified="2001-03-01" version="1">MLNSLVRKNLAIGLVITAVMTTLSVFMADDGSRMAEFKMSLMVGFLVTGAVTGGTWLVQRKRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWT2</accession>
    <name>Q9EWT2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0739</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625043.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027325.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0739"/>
    <dbReference type="GeneID" id="1096162"/>
    <dbReference type="KEGG" id="sco:SCO0739"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.729"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_14_1_11"/>
    <dbReference type="InParanoid" id="Q9EWT2"/>
    <dbReference type="OMA" id="PADVTGY"/>
    <dbReference type="PhylomeDB" id="Q9EWT2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="308" mass="33485" checksum="D7BD8D12D812832B" modified="2001-03-01" version="1">MTGSSKGPLAGRVALVAGATRGAGRGIAVELGAAGATVYVTGRSTRVRRSEYDRPETIEDTADLVTEAGGHGVAVPADHLDPDQVAAVVDRIASEQARLDILVNDIWGGETLFEWDSPVWEHDLDKGLRLLRLAVETHAITSHHALPLLLRRPGGLVVEVTDGTDAYNRDHYRNSFFYDLAKTSVLRMAFSLGHEVGPRGATAVALTPGWLRSEIMLDHFGVREENWRDALDRVPHFAISETPRYVGRAVTALAADPGVARFNGRSFSSGSLAREYGFTDLDGSRPDAWRYLVEVQDADKPADVTGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2S5</accession>
    <name>Q9F2S5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4464</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628630.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029673.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4464"/>
    <dbReference type="DNASU" id="1099904"/>
    <dbReference type="GeneID" id="1099904"/>
    <dbReference type="KEGG" id="sco:SCO4464"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4534"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_3_11"/>
    <dbReference type="InParanoid" id="Q9F2S5"/>
    <dbReference type="OMA" id="WHKSNAL"/>
    <dbReference type="PhylomeDB" id="Q9F2S5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="25276" checksum="5708F63DED129EE5" modified="2001-03-01" version="1">MSYTEEWVTARARGAYEHGRASFDVRPERTALLVIDMQDEFVRPGWSPYWVPAATRMAPRLRRLIEGCRSAAVPVIWSIFDDTHLGLDRPKALGYLPHADTDWRRPGPAEVWDQMGRRPDEALIRKPSYGAFYDTPLDTMLRNLGRDTVIVTGTLTNYCCGTTARQAYERGYKVVFGADVTATDDESRQEPELAVLRKGFALVLTAEEITNQLAAGAHVRHGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2V3</accession>
    <name>Q9F2V3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">SCO4608</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628770.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029760.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4608"/>
    <dbReference type="GeneID" id="1100048"/>
    <dbReference type="KEGG" id="sco:SCO4608"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4680"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_1_11"/>
    <dbReference type="OMA" id="YYLQWTA"/>
    <dbReference type="PhylomeDB" id="Q9F2V3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC08261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="515" mass="53489" checksum="53E74FFB6A4AD2EE" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F352</accession>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
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    <dbReference type="InParanoid" id="Q9F352"/>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3A0</accession>
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        <submittedName>
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        </submittedName>
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        <lineage>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7575"/>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="GeneID" id="1103013"/>
    <dbReference type="KEGG" id="sco:SCO7575"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7690"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_0_3_11"/>
    <dbReference type="InParanoid" id="Q9F3A0"/>
    <dbReference type="OMA" id="SWPAIWM"/>
    <dbReference type="PhylomeDB" id="Q9F3A0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176675" evidence="1">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="30479" checksum="6977A032A1A31451" modified="2001-03-01" version="1">MASPRLLRSCLLATLSATLVAAAAVSPAQAERGPETAAAVTFSDTFDGPAGSGVDAAKWQLETGDNVSNHERQYYTPGTDNAKLDGRGNLVIEARRENPGNYQCWYGTCEYTSARLNTSGKFTATYGHVEARMKIPRGQGIWPAFWMLGQDIGEVGWPDSGEIDVMENVGFEPSTVHGTIHGPGYSGSGGIGAAYTLPNGEAFADAFHTFAVDWAPDRITWSVDGNVYQTRTPADLGGKAWVFDKPFFLILNLAVGGYWPGDPDGSTTFPQQLVVDEVKVTTSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3B7</accession>
    <name>Q9F3B7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO7558</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631601.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031744.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7558"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102996"/>
    <dbReference type="KEGG" id="sco:SCO7558"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7672"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F3B7"/>
    <dbReference type="OMA" id="WHVCEHG"/>
    <dbReference type="PhylomeDB" id="Q9F3B7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="437"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC16438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="52190" checksum="43466D931EE6AF39" modified="2001-03-01" version="1">MVTAAHRTASAPDAARTFPKGFLWGSATASYQVEGAAAEDGRTPSIWDTYARTPGRVRNGDTGDVATDHYHRRSEDVALMAELGLGAYRFSLAWPRIQPTGRGPAVQKGLDFYRRLVDELLEKGIQPVATLYHWDLPQELEDAGGWPERATAERFAEYAALAADALGDRVRTWTTLNEPWCSAFLGYGSGVHAPGRTDPVAALRAAHHLNLAHGLAVQALRERVRADAQVSVTLNIHHVRPLTGSEGDADAARRIDALANRVFTGPMLNGAYPEDLLKDTAELTDWSFVQDGDLRQAHQPLDFLGVNYYTPTVVSETDGSGAHTSDGHGNSSHSPWPGADRVAFHQPPGDTTAMGWAVDPTGLYDLLRRLSADFPRLPLVITENGAAFDDYADPEGQVNDPARIAYVRGHLAAVHQAILDGADVRGYFLWSLLDNFEWAHGYSKRFGAVYVDYPTGTRIPKASARWYSEVARTGVLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBJ2</accession>
    <name>Q9FBJ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5166</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629314.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030093.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5166"/>
    <dbReference type="GeneID" id="1100607"/>
    <dbReference type="KEGG" id="sco:SCO5166"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5249"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_27_0_11"/>
    <dbReference type="InParanoid" id="Q9FBJ2"/>
    <dbReference type="OMA" id="VANIEQH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="212"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC01367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="879" mass="92468" checksum="AA9B7FAB52823EF9" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC98</accession>
    <name>Q9FC98_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1215</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625504.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.1214"/>
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    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC01497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34591" checksum="E085DB7F34EA6E4C" modified="2001-03-01" version="1">MDHSGHGMTMDLPPFTLGRGLAWSADPFFLVACLLGLALYGWGVARLVRRGDKWPVGRTVAFVAGVLSVALMMCTKLNDYGMVMFSVHMVQHMVISMVSPILLLLGAPITLALRALPPAGRGRKGPRELLLMLLHSRYMRIITHPAFTIPLFIASLYALYFTPLFDTLMGSQAGHIGMMVHFLAVGVVFFWPIMGVDPGPHRPGYLMRMLELFAGMPFHAFFGIALMMASSPMVETFKNPPASLGIDALSDQNAAGGIAWAFSEVPSVLVLLALLFQWYASEERQARRSDRAADRDGDKELAAYNAYLASLNTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCJ9</accession>
    <name>Q9FCJ9_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5189"/>
    <dbReference type="GeneID" id="1100630"/>
    <dbReference type="KEGG" id="sco:SCO5189"/>
    <dbReference type="eggNOG" id="ENOG503493M">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153264_0_0_11"/>
    <dbReference type="OMA" id="EPWSDPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14163" checksum="2485E443AE0A1E88" modified="2001-03-01" version="1">MLYLHIRGLVRPSPPRRREEASPVISIKSSFIVSSTAKMTDRSAVSLCMLGASHSGTGLSGIRAVRPAAAAAAPAGLPVRERNERPTKALEAAVAAQAQAYAFTATGAGFRKQTTQHHLMWAFRGPEPWSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K2W6</accession>
    <name>Q9K2W6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase ECF sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1276</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1276"/>
    <dbReference type="GeneID" id="1096699"/>
    <dbReference type="KEGG" id="sco:SCO1276"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119079_0_0_11"/>
    <dbReference type="OMA" id="CDEDFGR"/>
    <dbReference type="PhylomeDB" id="Q9K2W6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB99156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="22531" checksum="881855988ECCA3A4" modified="2000-10-01" version="1">MAEQMESRPRFSLLNPRDNGLQSTMVRHSTCQSPAECSWEEIFQHQDRLMRLVRRRLPSFQDAEDCVQETMARAAAHAALDRNRLGAFLTSVALRLCIDFYRDMERRSRLLQRAALAETPGTTEEDVCDEDFGRWLLGQVQHLRGREQEVILARAKGISTAEFARIHNISVKAAEAAFTRGRARLKNVCAKALEGCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K455</accession>
    <name>Q9K455_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7230</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631286.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971915.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7230"/>
    <dbReference type="GeneID" id="1102668"/>
    <dbReference type="KEGG" id="sco:SCO7230"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7330"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="InParanoid" id="Q9K455"/>
    <dbReference type="OMA" id="HLEDKDR"/>
    <dbReference type="PhylomeDB" id="Q9K455"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB94653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="25127" checksum="3223E87AF7165971" modified="2000-10-01" version="1">MPRVLIIEDDRAVRDGVRLALRRQGHEVAAAATGEDGLEQLRSFRPDAVVLDLMLPGMSGLEVCRRIRAHDQVPIIMATARGDDTDIVVGLEAGADDYVVKPVRARILDARIRAVLRRVGGTADDQGTPRTEHHGDLVIDRAGLTVTHQGRPVALGPSELRLLLTLSASAGQVFSRQQLLEAVWEHNYHGDARLVDACVKRLRSKIGESPGSPRYVHTVRGFGYRFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4A3</accession>
    <name>Q9K4A3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5218</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629365.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030117.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5218"/>
    <dbReference type="GeneID" id="1100659"/>
    <dbReference type="KEGG" id="sco:SCO5218"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5302"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_14_11"/>
    <dbReference type="InParanoid" id="Q9K4A3"/>
    <dbReference type="OMA" id="VFAQYHR"/>
    <dbReference type="PhylomeDB" id="Q9K4A3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="220"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB94603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="47486" checksum="909A03B803678457" modified="2000-10-01" version="1">MDAVPARARVYVAVVALTALLCLRPLPAVRAPWWAVLLLAGLYAGSELVARSRFVGTCYPVLLAGAFLLPPPAAALVALPGALLAPVPRRPLGLRRVWRAAQLTLAVWAAACVHWRLGGRDAVVEPAFPYALVPAGAAVLAFCLVLTVLDGGILTLADHVPPSRAWRGLLSRSLAPIAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVAWWAFAQYHRERAAHQATIRALVQAVDIKDGYTRGHSERVGQASMMIARELGMDDERVETLRFAGILHDVGKLGVPTRLLRKDGPLTPEERRVIELHPEYGHEMVRGIRFLGEARAAVLHHHERLDGSGYPYGLAGDRIPESARVVAVADAFDAMTSTRSYSRARPVATALAELQRCAGGQFDPRMVRALVRALGRHGWRPSVTADSPLTRTAGPAPDRGEDARDSVGRGAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4D6</accession>
    <name>ATPD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name type="ordered locus">SCO5370</name>
        <name type="ORF">2SC6G5.14</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629509.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4D6"/>
    <dbReference type="SMR" id="Q9K4D6"/>
    <dbReference type="STRING" id="100226.SCO5370"/>
    <dbReference type="GeneID" id="1100810"/>
    <dbReference type="KEGG" id="sco:SCO5370"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5450"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088880_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4D6"/>
    <dbReference type="OMA" id="FRFGRIV"/>
    <dbReference type="PhylomeDB" id="Q9K4D6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
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        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
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        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
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        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
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        <property type="entry name" value="ATP_synt_delta"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000371171" description="ATP synthase subunit delta">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <sequence length="274" mass="29183" checksum="7F85F7268B7BBBB9" modified="2000-10-01" version="1">MSGMHGASREALAAARERLDALTDSTSVDAGSLADELAAVTALLHREVSLRRVLTDPAQSGEAKAELAQRLLGTQVSGTAVDLVAGTVRSRWSQSRDLVDALEQLANIADLTAAQKRGRLDNVEDELFRFGRIISSNTELRAALTSRSATTAAKSELLAGLLGSRAERTTERLVTRLVTAPRGRSLESGLESLSKLAADRRDRMVAVVTSAVPLSDTQKQRLGAALAKVYGRPMHLNLDVDPEVLGGIRVQVGDEVINGSIADRLEDAGRRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4G1</accession>
    <name>Q9K4G1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4177</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628353.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4177"/>
    <dbReference type="GeneID" id="1099617"/>
    <dbReference type="KEGG" id="sco:SCO4177"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4242"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_0_1_11"/>
    <dbReference type="OMA" id="VEIAVAW"/>
    <dbReference type="PhylomeDB" id="Q9K4G1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="89" mass="9484" checksum="4D3EE8592EF83D3D" modified="2000-10-01" version="1">MSWRRSSYSNSSGGNCVEVSDDLLRAADWRKSSYSNPDGGNCVEVAAGLPSLVPIRDSKDPARGALLFAAPAWAAFLDGVRREEPGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXZ2</accession>
    <name>Q9KXZ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2423</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626667.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028343.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2423"/>
    <dbReference type="GeneID" id="1097857"/>
    <dbReference type="KEGG" id="sco:SCO2423"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2464"/>
    <dbReference type="eggNOG" id="ENOG5033US4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304286_0_0_11"/>
    <dbReference type="OMA" id="AGACKFT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176752" evidence="1">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="20618" checksum="13CB0447192DD615" modified="2000-10-01" version="1">MKKNMRRSALVVCAAASALGLAAVPSSAVPSTVWTVNPSPAAFKAVNVGNIVLTATIPMTCTTSTAAGTMASATGNPGDVADITTMNFGASGSPCTSVLGNVTTTSVTPWDVVGVDYNSSTGVTKGYVGNVKANVTAGACKFTVTGKASGTYTNSTGVLAINSTAGELAVSNPVNCGAIVTTATKPTFKGNYAVTVASTGAIPTIVGSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYE1</accession>
    <name>Q9KYE1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4129</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628307.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974841.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4129"/>
    <dbReference type="GeneID" id="1099569"/>
    <dbReference type="KEGG" id="sco:SCO4129"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4191"/>
    <dbReference type="eggNOG" id="ENOG5032SPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636029_0_0_11"/>
    <dbReference type="OMA" id="ASAMIYR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="420" mass="42627" checksum="5D30D92C45AB8B89" modified="2000-10-01" version="1">MFSARAFAEPSPTPTKDDPCSLIAGPAKDYCERGEGGGSGGGGGTPDTLPSTLDPLSSLAKGCADAAAWTVDTLSDAVKNTADVDFTNDTFLKQYAVVFAASAFLTLILWLLAVAKRAVRGVPLTTALSEAVGFLWLTVLASAFTPLILYTVVSATDAVTDVLAKGTGDQTDTFFGTFSQALKQGNDIGGGPIMLILVSFVSIIAAGVLYLELYLRAVLLYVGALLGVVVYAGLVDKNLWGHVRRWAGIMIAVIMVKPVIVIVLGLAGALTTADGPDSVAAIVSGLAIILLAIFASAMIYRFVPGFGDEIANGRNNRIMQGAEGKAAAVISSPANLVAQGIRTHSSRHNGDGGGGQSSSSAAARPSNPASGGVAAHSSRPSNGGGGNVPSAAPAPRSGSPVNTPHASNTRNSQSTGGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYE4</accession>
    <name>Q9KYE4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4126</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029453.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4126"/>
    <dbReference type="GeneID" id="1099566"/>
    <dbReference type="KEGG" id="sco:SCO4126"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4188"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041672_0_0_11"/>
    <dbReference type="OMA" id="GYGLFWG"/>
    <dbReference type="PhylomeDB" id="Q9KYE4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="495" mass="53116" checksum="4DAFCC8C1AEE3799" modified="2000-10-01" version="1">MRPDDRRDQRPAQGGIPDGLLIGILAFLLGMTLLVWTATGLSALFAHGAWPDGVSFTGTPQAMRQLIAEPHDIPGAWPDAPEGALSGYGLFWGLFIGQLMVLVVLTVFVMGTVARWRAVRQRHREQPTPAPAPAPPAAPVAQETPVQEPPRHEVPTPRAPHQDPALETEPPASAANGKRLGGWETHRAEGAVHYGPGESRHSTAVQTLRDAEGAALVITSNPALWSETKDARAKLGPTHLYDPNHLCDTPARVHWSPTGGCEDRQTATARAAALLTPVRPTARLDQAIGDTAELLLRSYLHAAAIDGRTIRHVHRWSQGLQVQDAVRILRTHPKAAPGSAGELEGSLTAHPERRDMAQQLTARALAALSTVNIREACTPNRTDALALDSFVHEQGTLYVVGESIEDPRTSPGAMPLLTALVSSVVERGRRMAERSSSGRLDPPMTLVLDDVAAVAPLPQLPDLLAGGTDAGMPTLALLRSREQGRARWPHDELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYM5</accession>
    <name>Q9KYM5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7360</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971783.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7360"/>
    <dbReference type="GeneID" id="1102798"/>
    <dbReference type="KEGG" id="sco:SCO7360"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7463"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KYM5"/>
    <dbReference type="OMA" id="PLTQGWE"/>
    <dbReference type="PhylomeDB" id="Q9KYM5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="21971" checksum="060857BE91BB48F8" modified="2000-10-01" version="1">MHPDNPQPRSIAQVADSVRSGALIAYPTDSCYALGCRLGSRDGIDRIRSIRQLDNRHHFTLVCQDFAQLGQFVQIDNDVFRAIKASTPGSYTFILPATREVPRALQHPKKKTVGVRIPDHVVTQALLAELGEPLLSSTLLLPDEEEPMTQGWEIKDRLDHVLDAVVDSGDCGTEPTTVVDFSGGEAEIVRHGAGDTTRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYX3</accession>
    <name>Q9KYX3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3008</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627230.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975804.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KYX3"/>
    <dbReference type="STRING" id="100226.SCO3008"/>
    <dbReference type="GeneID" id="1098441"/>
    <dbReference type="KEGG" id="sco:SCO3008"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3067"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9KYX3"/>
    <dbReference type="OMA" id="VYAMREK"/>
    <dbReference type="PhylomeDB" id="Q9KYX3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="252" mass="27404" checksum="E0C6F9E7906A6436" modified="2000-10-01" version="1">MADSFGPMRGAGVDHGIDDGVAGMGPDAGSAREEPIRVLVVDDHALFRRGLEIVLAAEEDIQVVGEAGDGAEAVEKAADLLPDIVLMDVRMPKRGGIEACTSIKEVAPSAKIIMLTISDEEADLYDAIKAGATGYLLKEISTDEVATAIRAVADGQSQISPSMASKLLTEFKSMIQRTDERRLVPAPRLTDRELEVLKLVATGMNNRDIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ15</accession>
    <name>Q9KZ15_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative iron-sulfur oxidoreductase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2222</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626473.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028209.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2222"/>
    <dbReference type="GeneID" id="1097655"/>
    <dbReference type="KEGG" id="sco:SCO2222"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2259"/>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_17_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ15"/>
    <dbReference type="OMA" id="VACESSC"/>
    <dbReference type="PhylomeDB" id="Q9KZ15"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB90870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="39360" checksum="6E0C92A3361594A8" modified="2000-10-01" version="1">MSPNPSPRPTPKRTTALLLAAGTAGAALVVRRALRRRVQGSPLWPLPALDPPVSGRPRSRALTLLVTAHERLADGVVRLRLEGTDLPRWEPGAHLDLVLPSGLVRQYSLCGDPEDTSSYTVAARLVEDGRGGSREVHEQVQEGTELEVRGPRNRFPLVEAPAYAFVAGGIGITPLLPMLRALPEGTDWRLLYGGRTRASMPFLEEIEKLDPDGGRVVLVAEDEDGRPGLDAFLADLPEGAAVYCCGPEGLMAAVEERLPAGAALHLERFAPRTTADGDAEFEVELRRSGRTLTVPGDSSVLAAVRTELPNTPYSCEQGWCGTCQQKVLEGEIDHRDELLTDSERGDSMLICVSRCLGTRLVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ93</accession>
    <name>Q9KZ93_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629008.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974118.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4853"/>
    <dbReference type="GeneID" id="1100294"/>
    <dbReference type="KEGG" id="sco:SCO4853"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4931"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_3_11"/>
    <dbReference type="OMA" id="SARVWLE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="15015" checksum="99D32D78B6EB2E2B" modified="2000-10-01" version="1">MSDDESYELLGFDNVLLPVGDLAEAVGFYERAGFPVAYRLDEAGIALLKVGVETPGLLLRAEEEFGRQPPMWPSARVWLEVTDARAAARELREAGVPPLDEPFPVATGWTVEFADPWGNVIGLTDYSKRPELGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZG3</accession>
    <name>Q9KZG3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6989</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631054.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031360.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6989"/>
    <dbReference type="GeneID" id="1102427"/>
    <dbReference type="KEGG" id="sco:SCO6989"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7089"/>
    <dbReference type="eggNOG" id="COG3450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1609858_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZG3"/>
    <dbReference type="PhylomeDB" id="Q9KZG3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_3" evidence="1">
        <location>
            <begin position="98"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="176" mass="18903" checksum="75F89C244F8AB86E" modified="2000-10-01" version="1">MAGRTRAAEPHDVRAPRPLGEFCSRSSAAFGRDEVSAGRAGCPTPCLPRRPARPGYRRAMTHSFVVHVPDAELEPEPLDPGQILSGTPEVTGRVVWESPDGRRVRGVWQITPGVVTDTEADEMFVVLSGSATIEVAGGPTLTVGPGDLAVLREGDRTTWTVHETLRKAYAIDLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN9</accession>
    <name>Q9KZN9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1393</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027760.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1393"/>
    <dbReference type="GeneID" id="1096819"/>
    <dbReference type="KEGG" id="sco:SCO1393"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1401"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_11"/>
    <dbReference type="InParanoid" id="Q9KZN9"/>
    <dbReference type="OMA" id="WYSSTGW"/>
    <dbReference type="PhylomeDB" id="Q9KZN9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="100"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="658" mass="72138" checksum="34AF9A24FF22F11D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L018</accession>
    <name>Q9L018_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626543.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028258.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2295"/>
    <dbReference type="GeneID" id="1097729"/>
    <dbReference type="KEGG" id="sco:SCO2295"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2332"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079903_1_0_11"/>
    <dbReference type="OMA" id="RHYHHLG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="27380" checksum="A9B4829D5A5967E2" modified="2000-10-01" version="1">MRIGELADTVGVTTRTVRHYHHQGLLPEPERLANGYRTYTLRHVVVLARIRRLTELGLGLAEVRDVLADDAGKDLAEVLEELDSDLARQEAAIRERRTRLRALLGTEGGVPPEGPVSPELAELFAGIGDVSGSPMALRDREMLVLLESTVAPEERAGLLAAMRGALGSPEAAARARRTYELLDELADAGADDPRVAEAARVLADCMPAELLPEEGFDLDPGHGLLRALYADFAPAQAEAVRRAMEIAARGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0I5</accession>
    <name>Q9L0I5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4772</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628930.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029853.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4772"/>
    <dbReference type="GeneID" id="1100213"/>
    <dbReference type="KEGG" id="sco:SCO4772"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4845"/>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_3_11"/>
    <dbReference type="InParanoid" id="Q9L0I5"/>
    <dbReference type="OMA" id="WNECVAK"/>
    <dbReference type="PhylomeDB" id="Q9L0I5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="191"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="319"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="406" mass="44822" checksum="56382BC358EF91BA" modified="2000-10-01" version="1">MAQAGADETGRHVRYTYRLRVSSAARASLAAEWGRCRWLWNECVAKSRAVHLRNRATGEKATCGPAQLDRMLTEARARTPWLREGSCVPQQQVIRDFGRSRAKAHKDITEGLPVARRAGMPTWKTRRESPATLNYTRRGFRLKDGRLHLAGGIVLNVVWSRELPDEPSSVRVYQDSLGHWYCSFVVPAHVQPLPATGRVLGVDWGVRETATTTSDAHDLPHPSHGGKARARLARYDRMMARRRRKKGTAASSGYRAAKRLRAKAYKKVARQRADTGRKWAKKVVRDHDAVAVEDFRPKFLARSTMARKAADAAIGATKAALIEMGRKHGRDIRLVHPAYTTMDCAQCGARAKHALPLGERTHTCTACGTTSPRDKNSARVMLARAGLNPAGAEGGRPPGAPLQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0M1</accession>
    <name>Q9L0M1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4639</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628800.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4639"/>
    <dbReference type="GeneID" id="1100080"/>
    <dbReference type="KEGG" id="sco:SCO4639"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4710"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107158_0_0_11"/>
    <dbReference type="OMA" id="EANCAKG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB77413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21058" checksum="49EEBBCD3D2E09C2" modified="2000-10-01" version="1">MPTGVHLRDARRQLFDAAERVLLRDGPNGLTSRAVTDEAGCAKGVLHRHFADFDAFLVALVLDRAAQLDAQALTLREAVGSGTVADNLTGALTALFGPVPVAIIPLITFRDELRARLRQTVPGGGIAILAQVAAAVSAYLSEERARGRISADADIDSLTLSLVGGGHLLFADRDPGHPPAAAAVGKLVDTVLAGVVRRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Y4</accession>
    <name>Q9L0Y4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="11" type="ordered locus">SCO1475</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625756.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027807.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1475"/>
    <dbReference type="GeneID" id="1096901"/>
    <dbReference type="KEGG" id="sco:SCO1475"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1484"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015485_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L0Y4"/>
    <dbReference type="OMA" id="CTVEAAQ"/>
    <dbReference type="PhylomeDB" id="Q9L0Y4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="10">
        <location>
            <begin position="54"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="716" mass="75897" checksum="0141E771926137AF" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L103</accession>
    <name>Q9L103_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1456</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB76878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    <dbReference type="GeneID" id="1096882"/>
    <dbReference type="KEGG" id="sco:SCO1456"/>
    <dbReference type="HOGENOM" id="CLU_2060026_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="11405" checksum="0C321B11AE7778F3" modified="2000-10-01" version="1">MAAHGGLGRQRGVEGEGDVVPRRPVRLGGAGQGGGLPRGGPSCGLPSGPAATAAPVVAGVSSRAAQSAATVGAASHGGRPPWTEAGEPNGHHGPGAAPAPHRARDGSRLRRAAGRAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L133</accession>
    <name>Q9L133_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631475.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031656.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7426"/>
    <dbReference type="GeneID" id="1102864"/>
    <dbReference type="KEGG" id="sco:SCO7426"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7536"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131559_0_0_11"/>
    <dbReference type="OMA" id="LTWLPHG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15086" checksum="EDD0CAF37850BDED" modified="2000-10-01" version="1">MAAEDGGSPGTAGPPLPRVLCDTAELLSLGGDAPAGALWKLAEPGRQLDANVVRLPAGGRVDTHTEPDLDVLLLVLEGAARLDSSDGEHPLRAGVLTWLPHGSTRAVLAGPDGVTYLTVHRRRPGMRIQPPEAADRLRRSLGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1F7</accession>
    <name>Q9L1F7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO5448</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629585.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030252.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5448"/>
    <dbReference type="GeneID" id="1100888"/>
    <dbReference type="KEGG" id="sco:SCO5448"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5532"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="InParanoid" id="Q9L1F7"/>
    <dbReference type="OMA" id="ARWARYV"/>
    <dbReference type="PhylomeDB" id="Q9L1F7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB76002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="583" mass="60720" checksum="5603BFFF927E82FA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1V9</accession>
    <name>Q9L1V9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6826</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630897.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007445820.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6826"/>
    <dbReference type="GeneID" id="1102265"/>
    <dbReference type="KEGG" id="sco:SCO6826"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6935"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_2_0_11"/>
    <dbReference type="OMA" id="WHQGPDG"/>
    <dbReference type="PhylomeDB" id="Q9L1V9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="246"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB71914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="346" mass="37020" checksum="C6C6EAFA201D2C7E" modified="2000-10-01" version="1">MKTTDIRIAGLGTYIPEIVDARKAVALGLYDADDYEFYGWTGAAVADDMPAPDMAVAAARQAMERSALHPHDIDFHIHACGHEQGPEGWSPQHYILRHLTDRDVPSFRVWQACSGLIGSLELAACYLKAVPERSAALLTGADNVGTPNFNRWAFGIQNGVLGDGGSAILLSKSEGFASLLSINTGSTAEVEEQYRGTEPLFPPSLTVGRGMDFKERLAAAGGLEETVAEVVRRQGELRTEIALRTLAEAGLEPGDVTRVCHVFTGQESYLKVILDPMGLSPDQGLLDFGRNLGHMTVNDQIVGLTHLVETGQVGPGDHVLIVAHGGGVSITCAVVRIDQRPDWAAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-10" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L214</accession>
    <name>GPMI_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-independent PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">iPGM</shortName>
            <ecNumber evidence="1">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmI</name>
        <name type="ordered locus">SCO6818</name>
        <name type="ORF">SC1A2.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="1"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630890.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031205.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L214"/>
    <dbReference type="SMR" id="Q9L214"/>
    <dbReference type="STRING" id="100226.SCO6818"/>
    <dbReference type="GeneID" id="1102257"/>
    <dbReference type="KEGG" id="sco:SCO6818"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6927"/>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_11"/>
    <dbReference type="InParanoid" id="Q9L214"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="PhylomeDB" id="Q9L214"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044262">
        <property type="term" value="P:cellular carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212217" description="2,3-bisphosphoglycerate-independent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="511" mass="53353" checksum="0CD5E60F887587C3" modified="2000-10-01" version="1">MSTPEPVLAGPGILLVLDGWGSADAADDNALSLARTPVLDELVAQHPSTLAEASGEAVGLLPGTVGNSEIGHMVIGAGRPLPYDSLLVQQAIDSGALRSHPRLDAVLNEVAATSGALHLIGLCSDGQIHAHVEHLSELLAAAATHQVERVFIHAITDGRDVADHTGEAYLTRVAELAAAAGTGQIATVIGRGYAMDKAGDLDLTERAVALVADGRGSPADSAHSAVHSSERGDEWVPASVLTEAGDARVADGDAVLWFNFRSDRIQQFADRLHEHLTASGRTVNMVSLAQYDTRTAIPALVKRADASGGLADELQEAGLRSVRIAETEKFEHVTYYINGRDATVRDGEEHVRITGEGKADYVAHPHMNLDRVTDAVVEAAGRVDVDLVIANLANIDVVGHTGNLAATVTACEATDAAVDQILQAARNSGRWVVAVGDHGNAERMTKQAPDGSVRPYGGHTTNPVPLVIVPNRTDTPAPTLPGTATLADVAPTILHLLGHKPGPAMTGRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD00</accession>
    <name>Q9RD00_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="4" type="ordered locus">SCO0911</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625210.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027439.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0911"/>
    <dbReference type="GeneID" id="1096334"/>
    <dbReference type="KEGG" id="sco:SCO0911"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.905"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_9_2_11"/>
    <dbReference type="InParanoid" id="Q9RD00"/>
    <dbReference type="OMA" id="CRGTFRN"/>
    <dbReference type="PhylomeDB" id="Q9RD00"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB62702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="446" mass="49886" checksum="014A2ECE659B130C" modified="2000-05-01" version="1">MTDPTDAPATTTAEALRERALTTLVTARERTTLLTSCVEGPDLTAQVSPLMSPLVWDLAHIGNQEEQWLLRAVAGQEAIRPEIDSLYDAFEHPRSERPSLPLLSPAEARRYASDVRGRALDVLEATAFDGTRLTEAGFAFGMIAQHEQQHDETMLITHQLRKGPQALTAPDPDPVPLFTGPAEVLVPGGPFAMGTSTEPWALDNERPAHRREVAPYFIDTVPVTNGAYRAFIDDGGYDDPRWWTPEGWDHIRRHAVTAPLFWRRDGGQWLRRRFGVTEAVPADEPVLHVCWYEADAYARWAGRRLPTEAEWEKAARYDPAGDRAMRYPWGDADPGPEHANLGQRHLRPAPAGSYPAGESPLGVRQLIGDVWEWTSSDFTPYPGFRAFPYKEYSEVFFGPEYKVLRGGSFAVDAVACRGTFRNWDYPVRRQIFSGFRTARSASAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD17</accession>
    <name>Q9RD17_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0893</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625192.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027422.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0893"/>
    <dbReference type="GeneID" id="1096316"/>
    <dbReference type="KEGG" id="sco:SCO0893"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.885"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039510_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RD17"/>
    <dbReference type="OMA" id="TVAWAQG"/>
    <dbReference type="PhylomeDB" id="Q9RD17"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="2">
        <location>
            <begin position="27"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="44087" checksum="6197BA4E7F339769" modified="2000-05-01" version="1">MTLRPSPPHPDRRGPRIGVLGSYGGFNTGDEAILTCVLGCLRGRRPDAHLVVLSRNAEHTRAHHPDADEVVAWEGVSRNHVLDVLPGLDLLVLGGGGILYDGEARRYLRLVRAAQTRHVPTFAYAVGAGPLTDPEDRDAVRTVLAEMADVVVRDEESRLVLEEVGLEREVAVTADPALLLAPEPFTEAMMRDEGIPSGTRLVGMSVREPGRAAEKLDEGGYHALLADVADFLVRRLDARVVFLPMERHDVRHAHAVLSHMTAPDQGRILHGDYSPGQVLGFMRHLDVAVGMRLHFVIFAALTGVPVLPLPYSGKVFDFARRLGAPALVGVAREQAGLLLAEVDRLWDEYPRRRDDLRGRMGELSASARETCERCGALLDEIAAARGPGGTPAAGAGPCRAEPRPLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD76</accession>
    <name>Q9RD76_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0801</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625102.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027365.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RD76"/>
    <dbReference type="STRING" id="100226.SCO0801"/>
    <dbReference type="GeneID" id="1096224"/>
    <dbReference type="KEGG" id="sco:SCO0801"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.793"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_4_11"/>
    <dbReference type="InParanoid" id="Q9RD76"/>
    <dbReference type="OMA" id="HEPNWQL"/>
    <dbReference type="PhylomeDB" id="Q9RD76"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="527" mass="57742" checksum="4A612C1B7A894780" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDC9</accession>
    <name>LEPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">SCO2562</name>
        <name type="ORF">SCC77.29c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626800.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976242.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RDC9"/>
    <dbReference type="SMR" id="Q9RDC9"/>
    <dbReference type="STRING" id="100226.SCO2562"/>
    <dbReference type="GeneID" id="1097996"/>
    <dbReference type="KEGG" id="sco:SCO2562"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2607"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_11"/>
    <dbReference type="InParanoid" id="Q9RDC9"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="PhylomeDB" id="Q9RDC9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176351" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="622" mass="68378" checksum="83F5C76FA2A80C7C" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDQ5</accession>
    <name>Q9RDQ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2379</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626625.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976424.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2379"/>
    <dbReference type="GeneID" id="1097813"/>
    <dbReference type="KEGG" id="sco:SCO2379"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2420"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_35_1_11"/>
    <dbReference type="InParanoid" id="Q9RDQ5"/>
    <dbReference type="OMA" id="QVMIDSM"/>
    <dbReference type="PhylomeDB" id="Q9RDQ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16823" checksum="49602FBD55D81E34" modified="2000-05-01" version="1">MSLVRRAVAEDAEEVLRLRQVMIASMSPDAPTDWQAGSLPGLRSRLADPGGDFAAFVVDHPDRPDALAALVVGTLEYRIGGPDRPGGLLGYVFSVATDPDARRRGYARACMDELLAWFRERGAGHVMLTASPDAEPLYASMGFTRDATPSMRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI35</accession>
    <name>Q9RI35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative nitrate/nitrite transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0213</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37042">
        <property type="entry name" value="T37042"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624546.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026930.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0213"/>
    <dbReference type="GeneID" id="1095637"/>
    <dbReference type="KEGG" id="sco:SCO0213"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.184"/>
    <dbReference type="eggNOG" id="COG2223">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="197"/>
        </location>
    </feature>
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        <location>
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            <end position="243"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB53437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="41632" checksum="D65C575D5ED45E14" modified="2000-05-01" version="1">MLQPSTQHSEITSQSVPGRAWLMLALATLGFALNFWAWALLSPLGPRFKDSLDLSSFQQSLLVAVPVVVGSLGRIPVGALTDRFGGRVMFPLVSAATIVPVLYLGLAGHSSLTALLVGGFLLGIGGTAFAVGVPFTSAWFPPERRGLAIGIFGAGMGGTAISALTTVKLVDAYGMANPFLVTAAVLAVYAVVAALLLRDAPGRTVPAESLGHRMAATCKLGITWQASALYAVAFGGYVAFSVYLPTYLKTGYGLTQADAANRMAGFVLLAVAMRPMGGWLSDRLGPVKVLAGSLAVVLAGALAQSPTPALMPVGTIAFLAMAAALGAGSGAVFALVAFLSPANKVGSVTGMVGAAGGLGGFLPPLVMGTLYGSFGSYAIGLILLAAVAAAALAFTGTGLSHAVSRRATAHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI59</accession>
    <name>Q9RI59_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0119</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="100226.SCO0119"/>
    <dbReference type="GeneID" id="1095543"/>
    <dbReference type="KEGG" id="sco:SCO0119"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.96"/>
    <dbReference type="eggNOG" id="ENOG5031HMV">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176882" evidence="1">
        <location>
            <begin position="31"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="18531" checksum="8D4FF37DBD639FD0" modified="2000-05-01" version="1">MSVSRTARRAVLTAAVVCVSTLAVPSTAQAAPLPPACQEALLETLDKFPVVDFTVPDKVKNTMTAQVLGMSEADQAVFTEVACAAWNTWATQNGQAVATDLDSRYRNAAGPVCNKFARSALATIKKHSPNVPAETREMERVAKTVWRDSMEKLAADATNADCRTAYNAVKAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI95</accession>
    <name>Q9RI95_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0080</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36980"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095509"/>
    <dbReference type="KEGG" id="sco:SCO0080"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.68"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YfbM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18928" checksum="BFBA897AFCA2A8AF" modified="2000-05-01" version="1">MGIHCEYVRLSLAKLQRSLSDPSWAQDHIDELGDAWAEEDSLPPEKAPYFSIEKSWHKLHHLIAAHGGMPVDVIHGGAELPLEDDMDYGPARYLTPEDVARASGCLATTPFDELARHYDLAAMRSAEIYLLPESETGVPSDLDTLRHRYEELARFFSTVATAGDGVVLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB7</accession>
    <name>Q9RJB7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0647</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624956.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027270.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0647"/>
    <dbReference type="GeneID" id="1096070"/>
    <dbReference type="KEGG" id="sco:SCO0647"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.631"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RJB7"/>
    <dbReference type="OMA" id="TWATPRW"/>
    <dbReference type="PhylomeDB" id="Q9RJB7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="27675" checksum="D89487AC6507F8C8" modified="2000-05-01" version="1">MDGSRPLALVTGASSGIGYELAALFAEHGYDLVVNAEDERLEHAARRLRETGVRVRAVRADLRHPDGVDHLIAALTGLAVDVAALNAGVGQGGAFVDTDLADDQSVIDLDVTATVRLAKPLLRDMVARGVGRLMFTSSVAATMPGSFQSVYNASKSFVQSFAQALQEEVAGTGVTVTSFMPGPTETDFFRRAGMVDTKVGTMPKDDPAQVARQAFDAVMKGRGKLVTGSAKTKAQGVAAKVLPDRVKAAVHRRTAEPGTARGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJL7</accession>
    <name>Q9RJL7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0516</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624830.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027176.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0516"/>
    <dbReference type="GeneID" id="1095939"/>
    <dbReference type="KEGG" id="sco:SCO0516"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.496"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060745_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJL7"/>
    <dbReference type="OMA" id="WLKPHYA"/>
    <dbReference type="PhylomeDB" id="Q9RJL7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176907" evidence="2">
        <location>
            <begin position="33"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB58276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="392" mass="39917" checksum="7F4AF65AA51A854A" modified="2000-05-01" version="1">MNRRSLAGRLAALAAVTATLGGCAPDGGDDGAASPVSAPPGSTAQRTPGSGGTSARTPQGTLLVTDFGADTVTFVDPAGRGAAADLGSVRVGTAPYGIALGEDGTAWVATAEGVAAVDTRTRVRTALVPHRTDTGPVTTGEYRGGGMGIALSPDGSRVYVGVNVPGGKGTLEVVDTERREVTRVVPVGRRPFDVDVSRDGRQVYATNHDSFDVSVVDTGDWTARRIEVAPYGTEGGLGSWLKPHYAAVRPSDGALLLPFEGERLAVVDPGTGRVRTEDMTANTHQHGVTAGADGTLYVVGTGPIDPSEDDGPSLTVRTPEGDERVVPLDGPHETVALSADGRTAYVSGGFTRDGYWNGLSAVDVATGRVTRLPVGERPLAVAVLGGQGTGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ7</accession>
    <name>Q9RJQ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0583</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624895.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027220.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0583"/>
    <dbReference type="GeneID" id="1096006"/>
    <dbReference type="KEGG" id="sco:SCO0583"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.564"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RJQ7"/>
    <dbReference type="OMA" id="IHGQPFR"/>
    <dbReference type="PhylomeDB" id="Q9RJQ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036199">
        <property type="term" value="F:cholest-4-en-3-one 26-monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="44917" checksum="86320B142522C788" modified="2000-05-01" version="1">MSTAQQVPDILSPEFAANPYPAYRTMRDSAPLIRHEATQSWIVSRYEDVERVFKDRAGQFTTENYDWQIEPVHGRTILQLSGREHAVRRALVAPAFRGADLQERFLPVIERNSRELIDAFRHTGRADLVADYATRFPVNVIADMLGLDKADHDRFHGWYTSVIAFLGNLSGDQEVAAAGARTRTEFAEYMIPVIRERRENPGDDLLSTLCAAEVDGVRMSDEDIKAFCSLLLAAGGETTDKAIAGIFANLLAHPEQLAAVREDRSLIPRAFAETLRYTPPVHMIMRQTATDVTLSGGTIPAGATVTCLIGAANRDETRYRDPDRFDIMRDDLTTTTAFSAAADHLAFALGRHFCVGALLAKAEVEIGVGQLLDALPGLRTEDGFEVVERGVFTRGPQSLPVRFTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK54</accession>
    <name>Q9RK54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0323</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624649.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027018.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095747"/>
    <dbReference type="KEGG" id="sco:SCO0323"/>
    <dbReference type="HOGENOM" id="CLU_1365519_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="22076" checksum="0DCBBEC5585803B5" modified="2000-05-01" version="1">MDAVPRALRVGQYRPRCVAPAHVSVRGAQFLEAGGQLRPTVLGGGGKLEVDSVLHRLRVRDADEVDADRGRVRPVEAHGFQVRDARPLARRAPAERLRPEAAERRVVPGLEVHPYKLRRHPEPPALPRPRAARPSPRGPGRTGPDRPRRGAQQVRPVYQAPSMSELDPIQVTPGTTHRSLLGPQSSISMTMCEPSEVQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL32</accession>
    <name>Q9RL32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding-protein dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0455</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978411.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0455"/>
    <dbReference type="GeneID" id="1095878"/>
    <dbReference type="KEGG" id="sco:SCO0455"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.433"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="WNEYLYS"/>
    <dbReference type="PhylomeDB" id="Q9RL32"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB56685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="29893" checksum="31728C2D46D8C736" modified="2000-05-01" version="1">MKLGKRWLPAHILVWTYAVLLVVPLYYFLASAFKSNDEIFAHPFAPPSSLGLGNFRTAFESADLGLAVVNSALVTVFSLALTLLLAIPASFALARSTGRLAGVVEKVFSLGFLIPTFAALFPTFLLAAATGLFHTRIFMVLFLPATALPLSVVILVQFMRTIPPEMEEAARLDGASTFAVLRHVYTPMCLPGIATVLLLNFLTFWNEYLYSLVIIGPDPAQRTVQVALPTLKSITGTDYGVLTAGTVLTLVPVWLVYTLLQKRMQQALVSGAVKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-20" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL48</accession>
    <name>PCP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber>3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Pyroglutamyl-peptidase I</fullName>
            <shortName>PGP-I</shortName>
            <shortName>Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pcp</name>
        <name type="ordered locus">SCO0438</name>
        <name type="ORF">SCF51A.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624759.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027116.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RL48"/>
    <dbReference type="SMR" id="Q9RL48"/>
    <dbReference type="STRING" id="100226.SCO0438"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="GeneID" id="1095861"/>
    <dbReference type="KEGG" id="sco:SCO0438"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.415"/>
    <dbReference type="eggNOG" id="COG2039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RL48"/>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="PhylomeDB" id="Q9RL48"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <feature type="chain" id="PRO_0000184738" description="Pyrrolidone-carboxylate peptidase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="216" mass="22041" checksum="32D00F89C5149CE1" modified="2000-05-01" version="1">MTRVLITGFAPFGGERVNPSWQAASLVAAEPPAGLAVTAAELPCVFGESLDALRDAIRADNPDLVLCLGQAGGRPGVTVERVGINVDDARIPDNAGGQPIDEPVVPDGPAAYFSTLPVKACVAAMREAGVPAAVSNTAGTFVCNHVAYGLGHLIATEFPHLRGGFAHVPWAPEQVPDGTAPALPPATVAHGLRALLAAAARTPAEQDLKVTEGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U9</accession>
    <name>Q9S2U9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative citrate lyase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2033</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35062">
        <property type="entry name" value="T35062"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626293.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028109.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2033"/>
    <dbReference type="GeneID" id="1097467"/>
    <dbReference type="KEGG" id="sco:SCO2033"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2064"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044864_0_2_11"/>
    <dbReference type="InParanoid" id="Q9S2U9"/>
    <dbReference type="OMA" id="WDIHYLD"/>
    <dbReference type="PhylomeDB" id="Q9S2U9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="28469" checksum="514F1E7A7E6FB198" modified="2000-05-01" version="1">MTAPPLTWLYVPGDRPRVVAKALAAGADVVVVDLEDAVAADRKEYARDATAELLTEPQPVPVHVRVNALDGPLAAGDLAALAALPGLSGLRLPKVTAPEQVTGVAALTGGPPLYALLETALGVERAYRIAAAHPALRGIALGEADLRADLGVRGDAGLDWSRSRVVVAARAAGLAPPSQTVHPDTRDLEGLAASCAHGRALGFLGRAAIHPRQLPIIERAYLPTERELEEAETIVKAATVQPGAQALPDGRFIDAAVVATARRTLSLARRPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX25</accession>
    <name>Q9WX25_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3308</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36256">
        <property type="entry name" value="T36256"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627518.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028900.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3308"/>
    <dbReference type="GeneID" id="1098742"/>
    <dbReference type="KEGG" id="sco:SCO3308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3369"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032305_1_0_11"/>
    <dbReference type="OMA" id="CNGDAVP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="464" mass="47609" checksum="BE154984C9386713" modified="1999-11-01" version="1">MAGDDFAALLRELKERSGLSYGALGKRLHMSGSTLHRYVSGEVVPVEFAPVERLARVCRATPDELLELHRRWIRADALRGVKKDEAEGAEGSDGGETAEGAEGAAADSTASARAPSAAPPVPDTTPVPATPVPAAPVMATPVPVTPDATPAPGSVPPARDASGPARRRVPRAALYAATGVVAVSAAVALVANLVASPDDDGRHGPAGAVAQTSASVSGTATGPGSTSPGPSASTSAPSASASVSGTSSASPSRPATAAPSRQAPAGPPLTVSTTPYYWEVPCDHAFLVDRSPKNVPKPPPQQGAVGWAAPLKAVSANRQEVVLTVQGTGPETVVLEDLHVRVVSSGPALDWNQYVMGNGCGGQVDTASFDVSLDLGTPTAVPIGGQRDFPYSVTESDTEVFHATAHTSGQDVSWYLELEWSSGGRHGMTRVDDHGKPFRTSASRDDSYYAYPLGSDHWELVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7N6</accession>
    <name>Q9X7N6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35255">
        <property type="entry name" value="T35255"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630803.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031139.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6730"/>
    <dbReference type="GeneID" id="1102169"/>
    <dbReference type="KEGG" id="sco:SCO6730"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6837"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_5_0_11"/>
    <dbReference type="InParanoid" id="Q9X7N6"/>
    <dbReference type="OMA" id="LEPQFMQ"/>
    <dbReference type="PhylomeDB" id="Q9X7N6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="398" mass="41746" checksum="622A780F34364CD3" modified="1999-11-01" version="1">MPEAKTPTRTPGTEGPLAGVRVVELAGIGPGPFAAMFLADLGADVVRVDRPGGPGLGIDPAHDVTNRNKRSVVVDLKAPDGPARVLDLAERADVLIEGYRPGVAERLGVGPRDCHARNPRLVYGRMTGWGQEGPLARRAGHDIGYIALTGTLGMTGAPDVPPAAPANLLGDYAGGSLYLVVGILAALHHAREDGTGQVVDAAIVDGTAHLSAMIHGMLAAGAWQDRRGANLLDGGCPFYGTYETADGRYMAVGALEPQFYAEFMRLLGIPDLAPARDDPARWPELRAAVAARFKSRTRDEWTAVFADSDACTAPVLSLREAPHHPHLAARSTFTEHDGITQPAPAPRFSATPTTVRTGPALPGADTEAVVRDWGLPRAWGGPAPASLPNPNPAVHNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7S8</accession>
    <name>Q9X7S8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7272</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35336">
        <property type="entry name" value="T35336"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631328.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031557.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7272"/>
    <dbReference type="GeneID" id="1102710"/>
    <dbReference type="KEGG" id="sco:SCO7272"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7374"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125060_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7S8"/>
    <dbReference type="OMA" id="GHHDTAR"/>
    <dbReference type="PhylomeDB" id="Q9X7S8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13660" checksum="F8E673CB7771C727" modified="1999-11-01" version="1">MSAPTRRYEDAVARYFEAWNAGPDAVAKAVAAAWTEDGGYTDPLADVRGHERIAAVIVAAHEQFPGFSFRLAGPVDGHHDTARFSWELVSDAEEGLAPVAGFDVITLDGEDRIRSVFGFLDRVPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Y8</accession>
    <name>Q9X7Y8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2129</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35511">
        <property type="entry name" value="T35511"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626385.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976686.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2129"/>
    <dbReference type="DNASU" id="1097563"/>
    <dbReference type="GeneID" id="1097563"/>
    <dbReference type="KEGG" id="sco:SCO2129"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2164"/>
    <dbReference type="eggNOG" id="COG2867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128243_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7Y8"/>
    <dbReference type="OMA" id="MLGMIKR"/>
    <dbReference type="PhylomeDB" id="Q9X7Y8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB39856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="15895" checksum="6B99BFEF72E2D56B" modified="1999-11-01" version="1">MAEHTSSSITIEAAPADVMAVIADFARYPDWTGEVKEAQVLATDEQGRAEQVRLVMDAGAIKDDQTLGYTWTGEHEVSWTLVKSQMLRSLDGSYLLRPAGTGTEVTYRLTVDVKIPMLGMIKRKAEKVIIDRALAGLKKRVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8B5</accession>
    <name>Q9X8B5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3435</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36201">
        <property type="entry name" value="T36201"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627640.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028976.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3435"/>
    <dbReference type="GeneID" id="1098872"/>
    <dbReference type="KEGG" id="sco:SCO3435"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3497"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_11"/>
    <dbReference type="InParanoid" id="Q9X8B5"/>
    <dbReference type="OMA" id="FERYGKR"/>
    <dbReference type="PhylomeDB" id="Q9X8B5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="32338" checksum="792FB5B23BAC0768" modified="1999-11-01" version="1">MDLLSLRYFQSVARHQHISRAAEELRVAQPSVSRTIIRLESELGTPLFDRRGRRIRLNEHGAAFLVRVERALAELEDARREVADAGRGGPGRVAVAAETLLQLAGVLSAFRELRPGVGVRLFQAPVDSMRRHLRSGEVDFALASQPLTGPEVCSAELAREEVLLAVPVGHRLAGRERVAVAELADEDFVSTRPGHWQRALLERLFAREGLAPRVVCEGDEAAATPELVGAGVGIGLMPAVARRVLGEDGPVGWLRLDAPDCHRTLTLVWRRDAYLSPAALDFRRLAGERLMPDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8D5</accession>
    <name>Q9X8D5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36222">
        <property type="entry name" value="T36222"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627474.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028869.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3262"/>
    <dbReference type="REBASE" id="22995">
        <property type="entry name" value="ScoA3III"/>
    </dbReference>
    <dbReference type="GeneID" id="1098696"/>
    <dbReference type="KEGG" id="sco:SCO3262"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053447_0_0_11"/>
    <dbReference type="OMA" id="YACGPCN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="27727" checksum="E3218953908F8159" modified="1999-11-01" version="1">MIPLKRPGISANLEKRLTGKTKTLTDNLADPKNAREAWKSARTIRRDLKVLLASMAAGFARCMYCGDSLGTDIDHFKPIARDPLSAFIWANHFLACSHCNSNKKRDQYPCSPSGECLLVNPSKEDPYEHMNLNLPTGKYQGQTQKGKETIRVFGLSRPDLELGRAHAYVRCESMLRDWSTRVGNGQEEAASAVLKSLMIQPFADVLYAMIKKSEAPGAPNLFEADVLTALRSVRERIETQDVAASFRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G7</accession>
    <name>Q9X8G7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3343</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36292">
        <property type="entry name" value="T36292"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627552.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3343"/>
    <dbReference type="GeneID" id="1098780"/>
    <dbReference type="KEGG" id="sco:SCO3343"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3405"/>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160050_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8G7"/>
    <dbReference type="OMA" id="WNYTERT"/>
    <dbReference type="PhylomeDB" id="Q9X8G7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13053" checksum="DBCB6068ADC5DA93" modified="1999-11-01" version="1">MPRESRGVFNGGSFFMSVDQVQNIGGGEEGEKTGGEGVVAAAALRSYPVAPGYRLNVRSGPGTNYSTVRVLAEGSRVTINCQRTGQWVSGPYGTSNIWDNIGGGQYVSDAYILTGSDGWVAPRC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8H1</accession>
    <name>Y3348_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO3348</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3348</name>
        <name type="ORF">SCE7.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GppA/Ppx family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36297">
        <property type="entry name" value="T36297"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627557.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028926.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8H1"/>
    <dbReference type="SMR" id="Q9X8H1"/>
    <dbReference type="STRING" id="100226.SCO3348"/>
    <dbReference type="GeneID" id="1098785"/>
    <dbReference type="KEGG" id="sco:SCO3348"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3410"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_4_11"/>
    <dbReference type="InParanoid" id="Q9X8H1"/>
    <dbReference type="OMA" id="YVPKIGL"/>
    <dbReference type="PhylomeDB" id="Q9X8H1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000194310" description="Uncharacterized protein SCO3348">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="309" mass="33197" checksum="53FD6FFD37E16F0E" modified="1999-11-01" version="1">MRLGVLDVGSNTVHLLVVDAHPGARPLPAHSHKVELRLAQLLDEDGAIGPDGVDQLAAVVREALQAAEDKGVEDLLPFATSAVREASNADDVLARVRAETGVELTVLTGAEEARLTFLAARRWFGWSAGRLLVLDIGGGSLEIAYGMDEEPDAAVSLPLGAGRLTAARLPDDPPHPDDVRALRRHVRTEIARTVGEFSRLGAPDHVVATSKTFRQLARITGAARSAEGLYVQRELKRASLEAWVPRLAAMTSTERAELPGVSEGRAHQLLAGALVAEGAMDLFRVESLEICPWALREGVILRRLDHMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8N4</accession>
    <name>Q9X8N4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3378</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36389">
        <property type="entry name" value="T36389"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028944.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3378"/>
    <dbReference type="GeneID" id="1098815"/>
    <dbReference type="KEGG" id="sco:SCO3378"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3441"/>
    <dbReference type="eggNOG" id="ENOG502ZW1G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198401_0_0_11"/>
    <dbReference type="OMA" id="MAVAFTC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="59" mass="6190" checksum="A93CFBE955526C6D" modified="1999-11-01" version="1">MDYVSALLPPAVMAVFFIGLIRVIVKTQGGANKAKEDAVVDAALARAEGARQQSPHPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Q2</accession>
    <name>Q9X8Q2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3635</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36525">
        <property type="entry name" value="T36525"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627829.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029131.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1099071"/>
    <dbReference type="KEGG" id="sco:SCO3635"/>
    <dbReference type="HOGENOM" id="CLU_1905510_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14194" checksum="5C09B0B92DF41615" modified="1999-11-01" version="1">MPLRAVRGPPQPYGAHDARRRHQAPATRHRVSLHAHEDAVAPAPVSPRGRGHALRVGRLVQEGHAVAGESVHVVQVVPRPGGPDRAEVPLDRPRVVDDQHLRRGGERLEGVGDRPGAEDVGAGPGVVDLARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Z5</accession>
    <name>Q9X8Z5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3713</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36648">
        <property type="entry name" value="T36648"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627905.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029183.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3713"/>
    <dbReference type="GeneID" id="1099149"/>
    <dbReference type="KEGG" id="sco:SCO3713"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3774"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2994584_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="57" mass="6040" checksum="CA3A6B8E7030DF1C" modified="1999-11-01" version="1">MTADDRAVRGALTGRIAALYKELVCKSAAWGVANPTLGMPTRRRPVVAHVPEPAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X911</accession>
    <name>Q9X911_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3545</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36666">
        <property type="entry name" value="T36666"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975390.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3545"/>
    <dbReference type="GeneID" id="1098981"/>
    <dbReference type="KEGG" id="sco:SCO3545"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3601"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022532_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X911"/>
    <dbReference type="OMA" id="TYRDGGM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="167"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="505" mass="53867" checksum="E4DFBA5931438353" modified="1999-11-01" version="1">MSNASLSPLPSADRPDVATRLRDALLGASFTADGLLELLGAPAYAALSRSETVPALRATRGDTPLELLVRLFLLQQPVPHARVADVLPVDACLESGWLDHAGDDEVTATVDVRPYGGPGGEDWFVVSDLGCAVGGAGGIGNHAEGVVLGVGGASTTLAGLTVRTPVSAALDLGTGSGIQALHAAAHATRVTATDVNPRALHITALTLALSGAPAADLREGSLYEPVADDETYDLIVSNPPFVISPGARLTYRDGGMGGDDLCRSLVQQTGERLNEGGFAHFLANWQHVEGEEWTDRLRSWVPHGCDAWIVQREVQDVTQYAELWLRDAGDHRGDPADYQARYDAWLDEFEARKVKAVGFGWITLRRTGAADPSVVAEEWPHPVEQPLGETVRAHFDRVDYLRSHDDAALLEAHFTLSGEVVQEQVGLPGAEDPEHVVLRQNRGMRRATRVDTVGAGFAGVCDGTMSAGRILDAIAQLVGEDPVALRDRTPAQIRLLVEQGFLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X918</accession>
    <name>Q9X918_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36674">
        <property type="entry name" value="T36674"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627751.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029080.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3553"/>
    <dbReference type="GeneID" id="1098989"/>
    <dbReference type="KEGG" id="sco:SCO3553"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3609"/>
    <dbReference type="HOGENOM" id="CLU_157938_2_1_11"/>
    <dbReference type="OMA" id="TINWIRS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="75" mass="7814" checksum="904439457D13AE7D" modified="1999-11-01" version="1">MYQMVRARVGALVGGVLGAVRRRAARRDAGMVTSEYAMGIVAAVAFAVVLYKVVTSGTVSAELQGIVKGALDARM</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9X0</accession>
    <name>Q9X9X0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical hydrophilic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1902</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36916">
        <property type="entry name" value="T36916"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626168.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028039.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1902"/>
    <dbReference type="GeneID" id="1097336"/>
    <dbReference type="KEGG" id="sco:SCO1902"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1928"/>
    <dbReference type="eggNOG" id="ENOG5032ZZ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1947564_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="129" mass="13884" checksum="39271F87E6ADC636" modified="1999-11-01" version="1">MPPPGEFEDEAVQAERRGSGGGSPQGREGTERDGKGRGGGAKTRGNAAPTTRTLPRMPKPNGFAYTATASGTVHITHHNRPATTLNGSRAARFLEEVTAGDPQLVMARWTGTYKHGNERTARNHPRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA97</accession>
    <name>Q9XA97_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alkaline phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0828</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36441">
        <property type="entry name" value="T36441"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625128.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978031.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0828"/>
    <dbReference type="GeneID" id="1096251"/>
    <dbReference type="KEGG" id="sco:SCO0828"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.820"/>
    <dbReference type="eggNOG" id="COG3540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015982_2_1_11"/>
    <dbReference type="InParanoid" id="Q9XA97"/>
    <dbReference type="OMA" id="YEHMPIR"/>
    <dbReference type="PhylomeDB" id="Q9XA97"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD_N" evidence="2">
        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="181"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB48905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="553" mass="60566" checksum="DF2D89159CFDA08E" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAK0</accession>
    <name>Q9XAK0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3602</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35370">
        <property type="entry name" value="T35370"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627797.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975337.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3602"/>
    <dbReference type="GeneID" id="1099038"/>
    <dbReference type="KEGG" id="sco:SCO3602"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3659"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_4_1_11"/>
    <dbReference type="InParanoid" id="Q9XAK0"/>
    <dbReference type="OMA" id="KWSAKER"/>
    <dbReference type="PhylomeDB" id="Q9XAK0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="13"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="403" mass="40876" checksum="E1B1CAC30702449D" modified="1999-11-01" version="1">MHNTTAVLIELGAIILALGLLGRIAGRVGFSPIPLYLLAGLAFGHGGMLPMQASEEFTATGAEIGVILLLLLLGLEYSASELVTNLKTQYPSGAVDFVLNAVPGAVAALVLGWGPVAAVALAGVTWISSSGVIAKVLGDLGRLGNRETPVVLGVLVIEDLAMAVYLPILTALLAGVSLAGGAVTLLISLGTVGAVLYLALRHGRLISRAVSSDSAETLLLVVLGLTLVVAGLAQELQVSAAVGAFLVGIALSGEVAEGASSLLTPLRDLFAAVFFVFFGLSTNPADIPPVLVPALLLAAVTALTKVATGWYAAHRAGLRGAGRWRAGGTLVARGEFSIVIAGLAVGVEPRIGPLATAYVLILVVIGPLTARFTEPLARRLTRGPRKAAPATATTPAESTHANA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAN3</accession>
    <name>Q9XAN3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6697</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35015">
        <property type="entry name" value="T35015"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630770.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031113.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6697"/>
    <dbReference type="ESTHER" id="strco-SC4C6.07C">
        <property type="family name" value="Carboxymethylbutenolide_lactonase"/>
    </dbReference>
    <dbReference type="PeroxiBase" id="4672">
        <property type="entry name" value="ScoHCMDn01"/>
    </dbReference>
    <dbReference type="GeneID" id="1102136"/>
    <dbReference type="KEGG" id="sco:SCO6697"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6804"/>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_54_1_11"/>
    <dbReference type="InParanoid" id="Q9XAN3"/>
    <dbReference type="OMA" id="AYAACCD"/>
    <dbReference type="PhylomeDB" id="Q9XAN3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026968">
        <property type="entry name" value="PcaD/CatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02427">
        <property type="entry name" value="protocat_pcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="CMD" evidence="3">
        <location>
            <begin position="282"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="375" mass="39873" checksum="67176A8F3E61EECC" modified="1999-11-01" version="1">MTTMLNHLSEGPASAPPLLLGPSLGTSYALWDAVAPELSVRHRVIRWDLPGHGGSRADLIGPGATVGDLADLVLALADSLGVERFAHAGVSLGGAVGLHLAVHHPERVSSLAVVCSSAHFNGAKPWEERAAQVRTEGLARLADSADARWFVPGFTVPRLVRDHREADPGAYAACCDALAAFDLRERVGEISAPTLLVAGREDPATPPSHLREIADAVPGATLTEIPGASHLAPAERPEAVLTALRAHFDGAARRGMAVRREVLGDAHVDRAQARQSPFTARFQDFISRYAWGEIWTDETLSRRERSMVTLTALVAHGHYEELAMHVRAARRNGLTPDEIGAVLLQTAVYCGVPAANSAFATAQRVLAEEADGTAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4V8</accession>
    <name>YOEB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Toxin YoeB</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Endoribonuclease YoeB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Putative mRNA interferase YoeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">yoeB</name>
        <name type="ordered locus">SCO2236</name>
        <name type="ORF">SCBAC17D6.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Microbiology" volume="145" first="2313" last="2322">
            <title>Nitrogen metabolism in Streptomyces coelicolor A3(2): modification of glutamine synthetase I by an adenylyltransferase.</title>
            <authorList>
                <person name="Fink D."/>
                <person name="Falke D."/>
                <person name="Wohlleben W."/>
                <person name="Engels A."/>
            </authorList>
            <dbReference type="PubMed" id="10517584"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with YefM which inhibits its toxin activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="Y17736">
        <property type="protein sequence ID" value="CAB38326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC37262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T51757">
        <property type="entry name" value="T51757"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626486.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976577.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z4V8"/>
    <dbReference type="SMR" id="Q9Z4V8"/>
    <dbReference type="STRING" id="100226.SCO2236"/>
    <dbReference type="PRIDE" id="Q9Z4V8"/>
    <dbReference type="GeneID" id="1097669"/>
    <dbReference type="KEGG" id="sco:SCO2236"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2274"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_11"/>
    <dbReference type="InParanoid" id="Q9Z4V8"/>
    <dbReference type="OMA" id="KCRFHYD"/>
    <dbReference type="PhylomeDB" id="Q9Z4V8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016892">
        <property type="term" value="F:endoribonuclease activity, producing 3'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903507">
        <property type="term" value="P:negative regulation of nucleic acid-templated transcription"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="chain" id="PRO_0000404327" description="Toxin YoeB">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="84" mass="9986" checksum="6AD38B9AA0158871" modified="1999-05-01" version="1">MRITFTSHGWEDYVHWAESDRKVTKRINRLIADIARDPFKGVGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDQLVIVQARYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z553</accession>
    <name>Q9Z553_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6119</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35902">
        <property type="entry name" value="T35902"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630225.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030664.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6119"/>
    <dbReference type="GeneID" id="1101560"/>
    <dbReference type="KEGG" id="sco:SCO6119"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6222"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066193_3_1_11"/>
    <dbReference type="InParanoid" id="Q9Z553"/>
    <dbReference type="OMA" id="RSGYADQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="23641" checksum="B3E0891DB0BB3BB4" modified="1999-05-01" version="1">MYAERASRLSGAVVWTDTPSGPGPGRVLPDGCMDLLWYDGRLLVAGPDTRAHVTEGGAGAWAGVRFCPGTAPALLGVPADALRDRRVELTDLWPTARARRLAARVNAAADPATGLDEAALARAAEAGPPDPLLARVVAALDAGRPVAATADALGIGARRLHRRSLAAFGYGPKTLARVLRLQRALALARNGTPLAETAARTGYADQAHLTRDVRELAGATPLELLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBF2</accession>
    <name>Q9ZBF2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ADA-like regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6461</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35948">
        <property type="entry name" value="T35948"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630546.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972517.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6461"/>
    <dbReference type="GeneID" id="1101900"/>
    <dbReference type="KEGG" id="sco:SCO6461"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6561"/>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_6_11"/>
    <dbReference type="InParanoid" id="Q9ZBF2"/>
    <dbReference type="OMA" id="RWPDAFP"/>
    <dbReference type="PhylomeDB" id="Q9ZBF2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA22770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="490" mass="53137" checksum="859C87FE03D18692" modified="1999-05-01" version="1">MHTDTERCVRAVQSKDARFDGWFFTAVLTTGIYCRPSCPVVPPKPGNMTFYPSAAACQQAGFRACKRCRPDTSPGSPEWNRRADLTARAMRLIADGVVDREGVPGLASRLGYSTRQVERQLLAELGAGPLALARAQRAQTARLLIETTPLPMADIAFAAGFSSIRTFNDTVREVYALSPSELRTRAPRNRRAATAPGALSLRLPFRAPLNPDNLFGHLAATAVPGVEEWRDGAYRRTLRLPYGHGIVALTPNPDHIACRLTLSDLRDLTVAISRCRRLLDLDADPTAIDDQLRADPLLAPLVDKAPGRRVPRTVDEAEFAVRAVLGQQVSTAAARTHAARLVTAHGDPVDDPEGGLTHLFPSTEALAAVDPETLAMPRTRRTTFTTLVAHLADGSVNPGVESDWAETRARLLALPGFGPWTADVIAMRALGDPDAFLPTDLGIRRAAAELGLPSTPAALTARAAAWRPWRAYAVQYLWATDDHPINFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBF8</accession>
    <name>Q9ZBF8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6455</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35942">
        <property type="entry name" value="T35942"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972523.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6455"/>
    <dbReference type="GeneID" id="1101894"/>
    <dbReference type="KEGG" id="sco:SCO6455"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6555"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9ZBF8"/>
    <dbReference type="OMA" id="CDRTVHW"/>
    <dbReference type="PhylomeDB" id="Q9ZBF8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24022" checksum="C1E11AC94A937BB3" modified="1999-05-01" version="1">MLELRTVTAGYARNAPVFRDVSLTVAPGEAVGLLGPSGCGKSTLARVAALLHQPDAGALHLDGTPVRHWRHRAPREQRTAFGVVFQQARLSADPRLRLADLIAEPLRATGRREGAADRVAELSATVGLTADLLTRRPHEVSDGQLQRACLARALVLRPRWLVCDEMTAMLDASTTAALVRVVEDYRAATGAGLLAVGHDRVLLDRWCDRTVEWASLVSAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBP6</accession>
    <name>Q9ZBP6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO5583</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35667">
        <property type="entry name" value="T35667"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629718.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030319.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5583"/>
    <dbReference type="GeneID" id="1101024"/>
    <dbReference type="KEGG" id="sco:SCO5583"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5674"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBP6"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="PhylomeDB" id="Q9ZBP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072488">
        <property type="term" value="P:ammonium transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAA22426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="46323" checksum="19BCB35AD6ECED5F" modified="1999-05-01" version="1">MAPAITLAAETELSAANTGFMLICSALVMLMTPALAFFYGGMVRVKSTLNMLMMSFISLGIVTVLWVLYGFSMAFGTDSGSVVGWNSDWVGLSDIGLTELWDGYTIPVFVFLVFQLMFAVLTPALISGALADRVKFTAWALFIALWATIVYFPVAHWVWGAGGWAFELGVIDFAGGTAVHINAGAAALGVILVIGKRVGFKKDPMRPHSLPLVMLGAGLLWFGWFGFNAGSWLGNDDGVGALMFVNTQVATGAAVLGWLAYEKIRHGAFTTLGAASGAVSGLVAITPAGGAVSPLGAIAVGLVAGVVCAMAVGLKYRFGYDDSLDVVGVHLVGGILGSLLIGFFASGKGQSDVEGLFYGGGLDQFWKQCAGVFGVLAYSLVVSAVLAFLLDKTIGMRVSEDVEVAGIDQAEHAETAYDFSGAGGGAARTTATPAASTAGSAPSKKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ9</accession>
    <name>Q9ZBQ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5570</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35654">
        <property type="entry name" value="T35654"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629705.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973424.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5570"/>
    <dbReference type="GeneID" id="1101011"/>
    <dbReference type="KEGG" id="sco:SCO5570"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5659"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ9"/>
    <dbReference type="OMA" id="RLDHRNP"/>
    <dbReference type="PhylomeDB" id="Q9ZBQ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="23540" checksum="28E5FA887DAA8984" modified="1999-05-01" version="1">MVLNARLDHRDPLVFDTHELGRRPGALQRLTRTVDAPKDFGLQGVIGVPEGAPVELDLRLESVMEGVLVTGTARARAAGECVRCLEPLEQQLEADFQELFSYPDADDRGRPVAEPGDDAEDDEDRFFVEDGLIGLEPVLRDAVVLALPMQPVCQEDCRGLCSQCGVRLSDDPDHHHDAVDIRWAALQGLAGSLGDGEKDEMSGDGADSADAAEKQEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>O08333</accession>
    <name>PFP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="1">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pfkA1</name>
        <name type="synonym">pfk1</name>
        <name type="synonym">pfkA</name>
        <name type="synonym">pfp</name>
        <name type="ordered locus">SCO2119</name>
        <name type="ORF">SC6E10.13c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Appl. Environ. Microbiol." volume="63" first="956" last="961">
            <title>Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic pathway of the actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Alves A.M.C.R."/>
                <person name="Euverink G.J.W."/>
                <person name="Bibb M.J."/>
                <person name="Dijkhuizen L."/>
            </authorList>
            <dbReference type="PubMed" id="9055413"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / 1109</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Biol. Chem." volume="283" first="25186" last="25199">
            <title>Antibiotic overproduction in Streptomyces coelicolor A3(2) mediated by phosphofructokinase deletion.</title>
            <authorList>
                <person name="Borodina I."/>
                <person name="Siebring J."/>
                <person name="Zhang J."/>
                <person name="Smith C.P."/>
                <person name="van Keulen G."/>
                <person name="Dijkhuizen L."/>
                <person name="Nielsen J."/>
            </authorList>
            <dbReference type="PubMed" id="18606812"/>
            <dbReference type="DOI" id="10.1074/jbc.M803105200"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">No effect.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3 4">Was originally characterized as ATP-dependent phosphofructokinase (PubMed:9055413). However, inspection of the original N-terminal sequence showed that the characterized enzyme was not pfkA1 (SCO2119), but pfkA2 (SCO5426) instead, another isozyme in S.coelicolor (PubMed:18606812).</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="1"/>
    <dbReference type="EMBL" id="U51728">
        <property type="protein sequence ID" value="AAC45135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35500">
        <property type="entry name" value="T35500"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626376.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976696.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08333"/>
    <dbReference type="SMR" id="O08333"/>
    <dbReference type="STRING" id="100226.SCO2119"/>
    <dbReference type="GeneID" id="1097553"/>
    <dbReference type="KEGG" id="sco:SCO2119"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2154"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_11"/>
    <dbReference type="InParanoid" id="O08333"/>
    <dbReference type="OMA" id="TNRDNPF"/>
    <dbReference type="PhylomeDB" id="O08333"/>
    <dbReference type="BRENDA" id="2.7.1.11">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="O08333"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000111986" description="Pyrophosphate--fructose 6-phosphate 1-phosphotransferase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18606812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="18606812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="9055413"/>
        </source>
    </evidence>
    <sequence length="342" mass="36664" checksum="CEEFC7B74092AB34" modified="1997-07-01" version="1">MKVGVLTGGGDCPGLNAVIRAVVRKGVQEYGYDFTGFRDGWRGPLEGDTVPLDIPAVRGILPRGGTVLGSSRTNPLKQRDGIRRIKDNLAALGVEALITIGGEDTLGVATRLADEYGVPCVGVPKTIDNDLSATDYTFGFDTAVGIATEAIDRLHTTAESHMRVLVVEVMGRHAGWIALHSGLAGGANVILIPEQRFDVEQVCSWVTSRFRASYAPIVVVAEGAMPRDGDMVLKDESLDSYGHVRLSGVGEWLAKQIEKRTGNEARTTVLGHVQRGGTPSAFDRWLATRFGLHAVDCVHDGDFGKMVALRGTDIVRVPIAEATARLKTVDPALYEEVGVFFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-09-18" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O50499</accession>
    <name>NGCE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacetylchitobiose binding protein NgcE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ngcE</name>
        <name evidence="7" type="ordered locus">SCO6005</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2018" name="Microbes Environ." volume="33" first="272" last="281">
            <title>NgcESco acts as a lower-affinity binding protein of an ABC transporter for the uptake of N,N'-diacetylchitobiose in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Iinuma C."/>
                <person name="Saito A."/>
                <person name="Ohnuma T."/>
                <person name="Tenconi E."/>
                <person name="Rosu A."/>
                <person name="Colson S."/>
                <person name="Mizutani Y."/>
                <person name="Liu F."/>
                <person name="Swiatek-Polatynska M."/>
                <person name="van Wezel G.P."/>
                <person name="Rigali S."/>
                <person name="Fujii T."/>
                <person name="Miyashita K."/>
            </authorList>
            <dbReference type="PubMed" id="30089751"/>
            <dbReference type="DOI" id="10.1264/jsme2.ME17172"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex NgcEFG-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Binds (GlcNAc)2. Can also bind GlcNAc.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of two ATP-binding proteins (MsiK), two transmembrane proteins (NgcF and NgcG) and a solute-binding protein (NgcE).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Constitutively expressed. Slightly induced by GlcNAc, (GlcNAc)2 and chitin. Repressed by DasR.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Disruption of the gene delays (GlcNAc)2 consumption, but does not affect GlcNAc consumption ability. Deletion reduces the level of chitinase activity induced in the presence of (GlcNAc)2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35670">
        <property type="entry name" value="T35670"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630119.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030591.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50499"/>
    <dbReference type="SMR" id="O50499"/>
    <dbReference type="STRING" id="100226.SCO6005"/>
    <dbReference type="GeneID" id="1101447"/>
    <dbReference type="KEGG" id="sco:SCO6005"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6103"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047233_0_0_11"/>
    <dbReference type="OMA" id="VYGVWYS"/>
    <dbReference type="PhylomeDB" id="O50499"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022386">
        <property type="entry name" value="Chitin_NgcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03851">
        <property type="entry name" value="chitin_NgcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" description="Tat-type signal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004159544" description="Diacetylchitobiose binding protein NgcE" evidence="1">
        <location>
            <begin position="38"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="30089751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="30089751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="30089751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAA15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="469" mass="50611" checksum="E1C4B383BA8C8B52" modified="1998-06-01" version="1" precursor="true">MTIRAGSLDRRTLLRGAIATAAMGSFAVACSSPSSEDKESDSGPKGEKSANNPFGAAANSTVEAAIFDGGYGTDYVDYANQVLGSQVKGLKVQVKPVVDIAPQLQPRFVGGNPPDLIDNSGEDQIGFLGILDQLEELDDLFEASTYEGKKIADIVYPGVKDPGTFKDKFVALNYVMTVYGVWYSKTLFEENGWTPPKTWDEALDLGQEAKKKGKYLFVHGKEAATYYRTLLIDSAIKEGGDEVRLALENLEKGCWSHPAVQGVIKVMETMVKQKMFVPGGSGTQFQKAQAIWSNDQKALLYPSGGWIENEMKKATKADFQMTGIPSMTLTDKPALPYEALRAAAGEPFIVPKQGKNPAGGKEVLRAMLSEKAAANFSKTKLAPTIVKGTVPADGYGSTALVSQTKMLEAAGTNIFNYMFVETYGLNTDQLVPWNSFLAGDLDGKGLTSALQKISDKVREDDSVDKVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O54113</accession>
    <name>O54113_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5917</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34589">
        <property type="entry name" value="T34589"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630035.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973104.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5917"/>
    <dbReference type="GeneID" id="1101359"/>
    <dbReference type="KEGG" id="sco:SCO5917"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6014"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_7_4_11"/>
    <dbReference type="OMA" id="QRINAEF"/>
    <dbReference type="PhylomeDB" id="O54113"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="112" mass="12563" checksum="887740745A07778E" modified="1998-06-01" version="1">MTADDSYGRLDDDDYPAYTMGRAAEMLGTTPAFLRAVGEARLITPLRSEGGHRRYSRYQLRIAARARELVDQGTPVEAACRIVILEDQLQEARRINEELQRRPAGLVDKAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O69862</accession>
    <name>O69862_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34712">
        <property type="entry name" value="T34712"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630143.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030606.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6032"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="DNASU" id="1101473"/>
    <dbReference type="GeneID" id="1101473"/>
    <dbReference type="KEGG" id="sco:SCO6032"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6132"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_11"/>
    <dbReference type="InParanoid" id="O69862"/>
    <dbReference type="OMA" id="AICVGGE"/>
    <dbReference type="PhylomeDB" id="O69862"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="39"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="506" mass="51745" checksum="A93A3B4075BA8161" modified="1998-08-01" version="1">MSSSKHSSELRRLALSVLQPGFVGTEAPDWVLRDIGDGLASVVLFSRNIVSTEQVARLTAQLRAENPDLIVAIDEEAGDVTRIESATGSSRPGNFALGTVDDPALTEAVAADLGRQLRAAGVSLDYAPSADVNSNPDNPIIGVRSFGSDPEVVARHTTAWIRGLQSSGVAACAKHFPGHGDVAVDSHHDLPAYTAGRDEIAAQALPPFRAAVAAGVRAVMSGHLLVPAHDPELPATLSRRILHDLLREELGFDGLVVSDAIEMGAVTRRYGIDGATVKAVGAGVDAICVGGESAEEATVALLVKALTAAVTGGELPEERLAGAAGRVREFARWSAGLRASGAAGEAAGDGIGHVAARRAVRLTGAARAALPLTAAPHVVELAPVTNMAIGKETPWGVAEPLRERLPGTTSVRVRGQELEEGTVALESCALEPAAGRPLVIVARDAARHAWMSRAVTGLTAARPDAIVVEMGLPGAGAAAAAQIFTHGASAASGVAAAEALTQAPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O69896</accession>
    <name>O69896_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34793">
        <property type="entry name" value="T34793"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629742.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030334.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5608"/>
    <dbReference type="GeneID" id="1101049"/>
    <dbReference type="KEGG" id="sco:SCO5608"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5700"/>
    <dbReference type="eggNOG" id="ENOG502ZPHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103770_0_0_11"/>
    <dbReference type="OMA" id="QDTHGRE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25572" checksum="ABFC5043C7D35586" modified="1998-08-01" version="1">MATTDGDEPPEEREFLTGDTPFVRVREALERLAALNEGPRVEQRVDRVDQIQNVFIGQGQDTHGREVAERAATRLAEQRQKFHFDFLNHALKQAEWTFRLSVWFMTGGALVILAGAVLALVHAGNPDLSYLPLVTSLTGALITVGGGALALHSKRAMANLTKAAEDNENKIDIDHKLEVATTFIDRVQDSQAKDRLNSAAALKALGMDAQPETMVNRLLPDPQTKEIDPGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O69905</accession>
    <name>O69905_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5617</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34802">
        <property type="entry name" value="T34802"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629751.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030343.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5617"/>
    <dbReference type="GeneID" id="1101058"/>
    <dbReference type="KEGG" id="sco:SCO5617"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5706"/>
    <dbReference type="eggNOG" id="ENOG5030DR8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2132122_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="138" mass="15143" checksum="9DF48626A2148E5E" modified="1998-08-01" version="1">MSNRDFSEDVQGPRSTDGPSVDDLRAEMYGGQVAGRFHYRESRTERDSAVIQGTPVLGDGTMTDDQAAEIRKSFGIGADLRHAAQAAESYMDRRDPTSGHTIRTYGNGRVVDLDAEPTQTGSDRVEYPRVWYGDDPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O69957</accession>
    <name>O69957_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5781</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35101">
        <property type="entry name" value="T35101"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629905.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5781"/>
    <dbReference type="GeneID" id="1101223"/>
    <dbReference type="KEGG" id="sco:SCO5781"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5871"/>
    <dbReference type="eggNOG" id="COG4696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097934_1_0_11"/>
    <dbReference type="InParanoid" id="O69957"/>
    <dbReference type="OMA" id="GPNYFKP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023292">
        <property type="entry name" value="NTP_PyroPHydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="18749" checksum="18BFBA91FB24EFC8" modified="1998-08-01" version="1">MAVATVVGMSSTPPAESGPPSAEGRTPPDQGRTSPDQGRTSPADLVRAFHLAFGLDARSTPTEVPPALAAHRGELLAEEAAEVAEVSVRGPLDRLAHELADVVYVAYGTALVHGIDLDAVIAEVHRSNMTKLGPDGRVSRRADGKVLKGDHYEIPDVSGVLRRQGWTPRTPDAPEPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-06-02" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O86606</accession>
    <name>O86606_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6337</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29423">
        <property type="entry name" value="T29423"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630429.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030838.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6337"/>
    <dbReference type="GeneID" id="1101778"/>
    <dbReference type="KEGG" id="sco:SCO6337"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_2_11"/>
    <dbReference type="InParanoid" id="O86606"/>
    <dbReference type="OMA" id="DEVKCRI"/>
    <dbReference type="PhylomeDB" id="O86606"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="115"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="310" mass="33156" checksum="F098B6829282FDF3" modified="1998-11-01" version="1">MTPSASSGCAGYSRSRGPASTGGWPARTRGPAGRGRTPSSPNASPGSIRNRTAPTGSARVTAELKDSGRRVNHKRGERVMRKFHIVGLHLRKKVRTTIPEPSATPVPDLLQRGIAAQMPNTKNVGDITCLPVGNGQFLYLATVLDLCSKRLTGWSIADHMPTSLVTDVLRAAARARGGDGLRGAISHSGNGAQYVSKEFAQVCSELGVTRSRGAVGTSADKAAAESLNTTMKRGTLQGRKRWNGASEARLAVFRWATRYNTRRRTPASARSARSPTNGDQLRWPPPHDNRCPRSQGRPSSVRAGGWPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O86726</accession>
    <name>O86726_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6544</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35236">
        <property type="entry name" value="T35236"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630625.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030998.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6544"/>
    <dbReference type="GeneID" id="1101983"/>
    <dbReference type="KEGG" id="sco:SCO6544"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6648"/>
    <dbReference type="eggNOG" id="ENOG502ZWHS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224187_0_0_11"/>
    <dbReference type="OMA" id="WESEESI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174888" evidence="2">
        <location>
            <begin position="46"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="23416" checksum="8FFF07237853D956" modified="1998-11-01" version="1">MNTNFTPPPMPSYGPSPVPPPPPPRKNRTLLVAVAAAVVAAAVSAAVTAGVTGDDEAGPAPTVTVTETASVGGGDTPAAEEESAEEAPAASEDTDDGVHALDETVTYEPDVEVSLSGFERTVSSEYAMPEKTPYARFTVKVRNSGTKTLDTTLLTVNCSYGKEGRSSESVFDSDTGLDGTPQTKLLAGRSINVPWGCELPKGEKLIQIEVAPDFDSETAIFTGPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O86790</accession>
    <name>O86790_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4749</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35578">
        <property type="entry name" value="T35578"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628907.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974224.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4749"/>
    <dbReference type="GeneID" id="1100190"/>
    <dbReference type="KEGG" id="sco:SCO4749"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4821"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440297_0_0_11"/>
    <dbReference type="OMA" id="ADGDAMW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174892" evidence="2">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="18992" checksum="8DC2E66D9F5182A8" modified="1998-11-01" version="1">MASRSAGIVTGLTTAALVTIGVLAHQASDSVPAGLDRTHATTSPAPGAAKAPRDRRHPDALPAMSGQGERVVYSVDDDRVWLVGPGNRVRRTFEVTPSTVDPAPGAYTVTSRSNRITGSDGIPVEHVVRFTGAQGVAIGFSAAVDGSTAAPDPDRPTGGIRESRADGDAMWKFATIGRQVVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O88050</accession>
    <name>O88050_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1590</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36825">
        <property type="entry name" value="T36825"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625866.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027868.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1590"/>
    <dbReference type="GeneID" id="1097021"/>
    <dbReference type="KEGG" id="sco:SCO1590"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1602"/>
    <dbReference type="eggNOG" id="COG1649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019247_0_1_11"/>
    <dbReference type="InParanoid" id="O88050"/>
    <dbReference type="OMA" id="YGPWSEY"/>
    <dbReference type="PhylomeDB" id="O88050"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003790">
        <property type="entry name" value="GHL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02638">
        <property type="entry name" value="GHL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174905" evidence="2">
        <location>
            <begin position="26"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GHL10" evidence="3">
        <location>
            <begin position="43"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="414" mass="45765" checksum="0DFCA7FF2B355E7D" modified="1998-11-01" version="1">MGGVSRRAFTVAALSAFTLVPEASAATPGPAKPAPPRSAAAGMRGMWLATVANRDWPTRAGLRAAEQRAELIEHLDNAVRHRLNTVILQVRPTADALWPSAHEPWSQYLSGSQGRDPGWDPLGTAVKEAHARGLHLHAWFNPYRVATHDDPARLVSSHPARKNPGWVVPYGGQLYYNPGLPEVRAFVQDAIMDAVTKYEVDGVHFDDYFYPYPVAGQSFDDGGTFGTFGSGFATQADWRRDNIDRLVRETAQRVKDVRPAARFGVSPFGVWRNAATDERGSDTRAGVQTYDDLYADTRKWVREGWIDYVVPQLYWNIGLDGADYAKLLPWWAETARGSRTQLYVGEALYKSGDPAQPAAWQDPAELSRHLTLAARYPEVHGHVYFSAKDVADDRGGAMTRLAADHYTQPAAAPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>P43414</accession>
    <accession>O86771</accession>
    <accession>Q9L0C1</accession>
    <name>KAD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <shortName evidence="1">AK</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk</name>
        <name type="ordered locus">SCO4723</name>
        <name type="ORF">SC6G4.01</name>
        <name type="ORF">SCD31.48</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Loriaux A."/>
                <person name="Brans A."/>
                <person name="Dusart J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="X83011">
        <property type="protein sequence ID" value="CAA58138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD55214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S50007">
        <property type="entry name" value="S50007"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733646.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029826.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P43414"/>
    <dbReference type="SMR" id="P43414"/>
    <dbReference type="STRING" id="100226.SCO4723"/>
    <dbReference type="GeneID" id="1100164"/>
    <dbReference type="KEGG" id="sco:SCO4723"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4794"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_11"/>
    <dbReference type="InParanoid" id="P43414"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="PhylomeDB" id="P43414"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000158856" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA58138." evidence="2" ref="1">
        <original>LKRD</original>
        <variation>PSAN</variation>
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="217" mass="23985" checksum="D330797711DD2BDC" modified="2001-10-18" version="3">MRIVLVGPPGAGKGTQATRLAETLHIPHISTGDLFRANISQQTELGKLAKSYMNAGNLVPDEVTIAMAKDRMEQPDAEGGFLLDGFPRNVSQAEALDELLETEGMKLDAVLDLEAPEDEVVKRIAGRRVCRNEPKHVFHVTYTPPKKEGVCDVCGGELYQRDDDSEETVRKRLEVYHTQTEPIIDYYKSQGLVATIAATGPVDEVTRRALEALKRDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q53915</accession>
    <accession>Q9L1S3</accession>
    <name>RF2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Peptide chain release factor 2</fullName>
            <shortName>RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">prfB</name>
        <name type="ordered locus">SCO2972</name>
        <name type="ORF">SCE59.31c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="5342" last="5345">
            <title>Properties of peptide chain release factor 2 from Streptomyces coelicolor A3(2): conserved primary structure but no frameshift regulation.</title>
            <authorList>
                <person name="Ogawara H."/>
                <person name="Urabe H."/>
                <person name="Ohtaki R."/>
                <person name="Nakamura Y."/>
            </authorList>
            <dbReference type="PubMed" id="7545157"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="D86821">
        <property type="protein sequence ID" value="BAA13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627196.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975840.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q53915"/>
    <dbReference type="SMR" id="Q53915"/>
    <dbReference type="STRING" id="100226.SCO2972"/>
    <dbReference type="GeneID" id="1098405"/>
    <dbReference type="KEGG" id="sco:SCO2972"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3030"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_11"/>
    <dbReference type="InParanoid" id="Q53915"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="PhylomeDB" id="Q53915"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166852" description="Peptide chain release factor 2">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA13170." evidence="2" ref="1">
        <original>QM</original>
        <variation>RV</variation>
        <location>
            <begin position="320"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="368" mass="41085" checksum="278071BE1A26C493" modified="2001-10-18" version="2">MAVVDVSEELKSLSSTMESIEAVLDLDRLRADIAVLEEQAAAPSLWDDPEAAQKITSKLSHLQAEVRKAEALRGRIDDLGVLFEMAEEEDDPDTRAEAESELAAVRKALDEMEVRTLLSGEYDAREALVNIRAEAGGVDAADFAEKLQRMYLRWAEQHGYKTEVYETSYAEEAGIKSTTFAVQSPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEILPVVEQTDHIEIDESELRVDVYRSSGPGGQGVNTTDSAVRLTHIPTGIVVSCQNERSQIQNKATAMNVLQAKLLERRRQEEQAKMDALKGDGGNSWGNQMRSYVLHPYQMVKDLRTEHEVGNPEAVFNGEIDGFLEAGIRWRKQREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKC9</accession>
    <name>Q7AKC9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7361</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631414.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031609.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7361"/>
    <dbReference type="GeneID" id="1102799"/>
    <dbReference type="KEGG" id="sco:SCO7361"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7464"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_542800_0_0_11"/>
    <dbReference type="OMA" id="CPAMDGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="427"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="509" mass="54399" checksum="7BB074DAAE0F1867" modified="2012-05-16" version="1">MAGRQDGGRQRTSGAGEPAGWAQELLDHLRPAGRDLNRVVAWLAGIARAAVALQDDTGRLLAGTRVPLDDVLVADLTSGRIASAALEDRGRHLRLVRVERSRPAPAAVLAVAREEPFDRRVSDIVTHAAQVLELLLAGHESTAAGHRLRRATSDLRLAILQLLMVEDTVSARRVAAGLWPGLLDTDTACVYVVESSPAERDRLAEECLSATGERALVVRCPAVDGHVIVLAPRDTAGQELRTLVGRRPGVFVGGSARQGLARTAAAYGQAVSALAVARFRPEKAALYAERTRPERLMDPAALHDWTADVLSPLDRLSHHTRAELIATTRLGLEFTAVNAAKVLGVSRNTVRARMDRVESLLRTDFADLTVRAAVHLALNAQVGLAEPPPGAGARAGAARLTDLLAGPALRTWAVDLLGRLDPDGRDLRRTLRTWIAAGGNAERAAQQLGMHAQTVREHVRSAEPVLERQLLAAGSDLYEVVLAHLAAGDLGQPLLHGTKPGHPDSPVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKE1</accession>
    <name>Q7AKE1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6861</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630931.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031246.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6861"/>
    <dbReference type="MEROPS" id="C14.A07"/>
    <dbReference type="GeneID" id="1102300"/>
    <dbReference type="KEGG" id="sco:SCO6861"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6971"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_482244_0_0_11"/>
    <dbReference type="InParanoid" id="Q7AKE1"/>
    <dbReference type="PhylomeDB" id="Q7AKE1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="298"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB72366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="565" mass="60370" checksum="7FFB28A79055CD5A" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q7BUY9</accession>
    <accession>O54595</accession>
    <name>Q7BUY9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Jag</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Jag-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">jag</name>
        <name evidence="6" type="ordered locus">SCO3884</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1992" name="J. Bacteriol." volume="174" first="3220" last="3226">
            <title>Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome.</title>
            <authorList>
                <person name="Calcutt M.J."/>
                <person name="Schmidt F.J."/>
            </authorList>
            <dbReference type="PubMed" id="1577691"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="1998" name="Gene" volume="217" first="83" last="90">
            <title>Gene organization in the trxA/B-oriC region of the Streptomyces coelicolor chromosome and comparison with other eubacteria.</title>
            <authorList>
                <person name="Gal-Mor O."/>
                <person name="Borovok I."/>
                <person name="Av-Gay Y."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
            </authorList>
            <dbReference type="PubMed" id="9795152"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(98)00357-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">3A</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="1999-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kim H.-D."/>
                <person name="Calcutt M.J."/>
                <person name="Schmidt F.J."/>
                <person name="Chater K.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="1313" last="1320">
            <title>Partitioning of the linear chromosome during sporulation of Streptomyces coelicolor A3(2) involves an oriC-linked parAB locus.</title>
            <authorList>
                <person name="Kim H.-J."/>
                <person name="Calcutt M.J."/>
                <person name="Schmidt F.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="10671452"/>
            <dbReference type="DOI" id="10.1128/JB.182.5.1313-1320.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="5">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">A3</strain>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF031590">
        <property type="protein sequence ID" value="AAC03486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF187159">
        <property type="protein sequence ID" value="AAF16007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36571">
        <property type="entry name" value="T36571"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628070.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029290.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3884"/>
    <dbReference type="GeneID" id="1099320"/>
    <dbReference type="KEGG" id="sco:SCO3884"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3957"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_3_0_11"/>
    <dbReference type="OMA" id="MLDIASW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC03486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF16007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB42701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="18352" checksum="5CC0D51EC8358A30" modified="2004-07-05" version="1">MTEGTISAAAEGADTLTRLEQEGEIAADYLEGLLDIADLDGDIDMDVEADRASVSIISDSKSRDLEKLVGRDGEVLEALQELTRLAVHRETGDRSRLMLDIAGYRADKRAELSELGAKAAAEVRSSGESVQLKPMTPFERKVVHDAVKAAGLRSESEGEEPERFVVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJJ6</accession>
    <name>Q8CJJ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7547</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAD55529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733737.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031740.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7547"/>
    <dbReference type="GeneID" id="1102985"/>
    <dbReference type="KEGG" id="sco:SCO7547"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7661"/>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006332_9_2_11"/>
    <dbReference type="InParanoid" id="Q8CJJ6"/>
    <dbReference type="OMA" id="DHGELHG"/>
    <dbReference type="PhylomeDB" id="Q8CJJ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="411"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="533" mass="59945" checksum="98EAA24150DFF00A" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK8</accession>
    <name>Q8CJK8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7173</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733725.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031478.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7173"/>
    <dbReference type="GeneID" id="1102611"/>
    <dbReference type="KEGG" id="sco:SCO7173"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7273"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="InParanoid" id="Q8CJK8"/>
    <dbReference type="OMA" id="WPFARAR"/>
    <dbReference type="PhylomeDB" id="Q8CJK8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="835"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="908" mass="98459" checksum="C3D5B12D49623331" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJR1</accession>
    <name>Q8CJR1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO5520</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAD55356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29050">
        <property type="entry name" value="T29050"/>
    </dbReference>
    <dbReference type="PIR" id="T35836">
        <property type="entry name" value="T35836"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733667.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973476.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5520"/>
    <dbReference type="GeneID" id="1100960"/>
    <dbReference type="KEGG" id="sco:SCO5520"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5607"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_11"/>
    <dbReference type="InParanoid" id="Q8CJR1"/>
    <dbReference type="OMA" id="WKPSPFA"/>
    <dbReference type="PhylomeDB" id="Q8CJR1"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="55"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD55356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="546" mass="59363" checksum="C77FF21A82C58A1F" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJT1</accession>
    <name>RPOC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">SCO4655</name>
        <name type="ORF">SCD40A.01</name>
        <name type="ORF">SCD82.27</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD55212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733644.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974308.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8CJT1"/>
    <dbReference type="SMR" id="Q8CJT1"/>
    <dbReference type="IntAct" id="Q8CJT1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="MINT" id="Q8CJT1"/>
    <dbReference type="STRING" id="100226.SCO4655"/>
    <dbReference type="PRIDE" id="Q8CJT1"/>
    <dbReference type="GeneID" id="1100096"/>
    <dbReference type="KEGG" id="sco:SCO4655"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4726"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_0_11"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="PhylomeDB" id="Q8CJT1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000067806" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="972"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144604" checksum="1A13B8CF7BCAE66F" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JD2</accession>
    <name>Q93JD2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5995</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630111.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030588.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5995"/>
    <dbReference type="GeneID" id="1101437"/>
    <dbReference type="KEGG" id="sco:SCO5995"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6094"/>
    <dbReference type="eggNOG" id="ENOG503402Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155842_0_0_11"/>
    <dbReference type="OMA" id="HRDIRHP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176581" evidence="2">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="24983" checksum="27D701FA15CE86A6" modified="2001-12-01" version="1">MSPSSSSPWLRRQLSRRGSAAVRSALLMSALAAVFVAGCTDGGGTTRSGAAEGKPTASAPSDASAPSFPPSPPAAAGCAGEMLDHRDIRHPDLGPVRVFLVRRSGSDGPAGCVAAVTGSGRALAPVEVDVNWSMEDPLRFAAPATDSTKNLFVVYNPGRYDGVLVLVPTADGFADIGWRSPDEHYSGGRFAFYYARPVGPGKDGEYAIVHYIKGCDPSCAEGATAKVTLRWDGHDYLPTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JG0</accession>
    <name>SEPF3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein SepF 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sepF3</name>
        <name type="ordered locus">SCO5967</name>
        <name type="ORF">SCBAC16H6.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630083.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93JG0"/>
    <dbReference type="SMR" id="Q93JG0"/>
    <dbReference type="STRING" id="100226.SCO5967"/>
    <dbReference type="GeneID" id="1101409"/>
    <dbReference type="KEGG" id="sco:SCO5967"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6065"/>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1926362_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JG0"/>
    <dbReference type="OMA" id="MHRVDRN"/>
    <dbReference type="PhylomeDB" id="Q93JG0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000334120" description="Cell division protein SepF 3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <sequence length="136" mass="14665" checksum="7C340AC57062D51A" modified="2001-12-01" version="1">MKSGEPVNSHDVTDEQWEGLAQVVPLRGRDAWPSAVGHRAMPEAETERRRRFVVLRINVFADAREVAETLMAGIPVLLDLTSAEGEVAKRVLDFSTGVVFGLASGMHRVDRNVFLLTPAGTEVNGLMESAAGVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JL3</accession>
    <name>Q93JL3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4981</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629133.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029985.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4981"/>
    <dbReference type="GeneID" id="1100422"/>
    <dbReference type="KEGG" id="sco:SCO4981"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5062"/>
    <dbReference type="eggNOG" id="COG4282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599798_0_0_11"/>
    <dbReference type="OMA" id="HIEVRGE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="466" mass="49864" checksum="D9A5930717DE1C5B" modified="2001-12-01" version="1">MSSIHDFATWEPLLRLVRASHPERLAGPGGHVMGQIGLGGWSVPVRRPHPAPGRASLVEDMQDEFTAVEAVQAALRAHGRQSVSFMVETRVDGRTALHVVDSGPAVEHGLVSPFVGTLVLVEGAVPEPWRRLPEAVPGALPAPSADPALLERTLRERLPDAVGATEAEIAEAQTRLGVTLPDELKALYRVVRARWQDWRGDYAAQERVVDAVGCELLPLDQLYVADARSRPCLWQFAATDAAVTAPDAAVQGLVGSPGWIAFGDNGGGDRLALDLTPGPGGHTGQVVMIGHEDSIGAGLLAESLTDMVVNGRAEWHPGRDWDRPPVVARLNVLGDDVSAVARPELEVLVLGGREGEPRSLAPLAGLPRLRTLHACPGALADPLEIAGLTRLEYLRLGPEEWRVLLDAGAVPRSLLAAHIEVRGEHHPPRIIALANELLSLWDRPLISRTVLEGDLDTDRTAQGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q41</accession>
    <name>Q99Q41_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.28c</name>
        <name evidence="2" type="ordered locus">SCP1.326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
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        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
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            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <dbReference type="EMBL" id="CAC36851.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="117" mass="12697" checksum="C1CC204FA891C361" modified="2001-06-01" version="1">MGHTPGALLITPEADIVPIDLPANSHERLTVMRSVIRCARVDVVALTSQMDMWLDDEGIYNHPVNKLASLLAVRFGFTHQPYHGPVLLTGGADNDGETVPLTKDKIVALLTSITDLL</sequence>
</entry>
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    </organism>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
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                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">A3</strain>
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    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
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    </evidence>
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    <sequence length="151" mass="16930" checksum="3751367AF04DA009" modified="2001-06-01" version="1">MMRPMRDDTVRDQIRFLRDCLDGEEALALVAGDGWPEPTGEVVSALRAGGFTDEQIRTIFTWGPGRAAVYADLLQRILDQLATLSSVRRPAHKEAVRRGIHSLLYLYRNAPGWEPKWGPDFPYARLSRVTRERAVELLADREQRAAGGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACQ6</accession>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
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                <person name="James K.D."/>
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                <person name="Howarth S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
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                <person name="Chen C.W."/>
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                <person name="Howarth S."/>
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                <person name="Murphy L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="87" mass="9641" checksum="05C7F8C54846D55A" modified="2001-06-01" version="1">MPSRTKTGLDEDEERVTRAQRLLIGLGAALVHTPFDTTTHDRLRSFLTDDADEVLTSLEALRRRPEAELRARIAELCGHSLLAEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN1</accession>
    <name>Q9ADN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti sigma factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4027</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628209.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974935.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4027"/>
    <dbReference type="GeneID" id="1099463"/>
    <dbReference type="KEGG" id="sco:SCO4027"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4090"/>
    <dbReference type="eggNOG" id="ENOG5032N5Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048492_0_0_11"/>
    <dbReference type="OMA" id="EPCDPPG"/>
    <dbReference type="PhylomeDB" id="Q9ADN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13462" checksum="EAADD89E9338905F" modified="2001-06-01" version="1">MTFRPQPWEPCEPCDPPGCAVLAMPSEIDFCNASGLLPLITTAVQQRSDGLRLLVLDLSGTRFMDSQGVRLIAAVRCRLPGGTLLRVVAAPKSVPSRVLELSGLRRDVPVHDNVAEALRAESGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK04</accession>
    <name>Q9AK04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631762.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7724"/>
    <dbReference type="GeneID" id="1103162"/>
    <dbReference type="KEGG" id="sco:SCO7724"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7846"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032305_1_0_11"/>
    <dbReference type="OMA" id="QDFAPVE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="471" mass="49466" checksum="DE8BF86C2CF08908" modified="2001-06-01" version="1">MGCLGCRPGLDRGSTRTGRPVPAQHDSDSTDAVDEFAALLRELKEHTDRSYGSLARRLGMNTSTLHRYCAGDTVPLDFAPVERFAALCGASPGQRLELHRRWLLAVAARHRPRTAEPGQGAPGTAEADTEQETDGGTDATPQPTGAPSAETAPVPPPPRRPWYRRRPLVAGTACVCAVLATLGALSALPDRQRASADGPAPASGPTASGTARARGSEPRDASPGPSGSPTAGTSEQPRGPAAPKQQPGTSRPHGTTAAPSPGEQPTGLPLTWSVNSQAWKLGCGHDYVIAKPPSQVPPPPAPQDAAPWAATQNAVHGKETLVQLSVQGRSDTAVVLEDLRVRVTGRAAPVEGNAYAMDQGCGGSITPRSFAVDLDKDRPIARAVAGNDSGTPIPAVRMPYRVSAKDPEVLLVTATAGACDCRWYLELDWSSQGRTGTVRIDDDGRPFRTTAIEGLPRYMYDTLGRTWGSYG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWW3</accession>
    <name>Y4941_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO4941</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4941</name>
        <name type="ORF">2SCK31.01c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC21613.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629093.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029964.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9EWW3"/>
    <dbReference type="SMR" id="Q9EWW3"/>
    <dbReference type="STRING" id="100226.SCO4941"/>
    <dbReference type="GeneID" id="1100382"/>
    <dbReference type="KEGG" id="sco:SCO4941"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5021"/>
    <dbReference type="HOGENOM" id="CLU_2234976_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205352" description="Uncharacterized protein SCO4941">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="105" mass="10992" checksum="4B5033296CAB1BB1" modified="2003-08-15" version="2">MTEALTHVIDHEGQGTPATVRLTVLPSGHTRVGVTDPDPRVPPLLPGPAGVTDESGRGLALLDAPAPRWGVEQRGDRRAVRCEPAGEPPLDDVRTPAAPAVRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX46</accession>
    <name>Q9EX46_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0992</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625288.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027501.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0992"/>
    <dbReference type="DNASU" id="1096415"/>
    <dbReference type="GeneID" id="1096415"/>
    <dbReference type="KEGG" id="sco:SCO0992"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.990"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_11"/>
    <dbReference type="OMA" id="VRHELYD"/>
    <dbReference type="PhylomeDB" id="Q9EX46"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="6"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="37709" checksum="EEDE87039D215BC7" modified="2001-03-01" version="1">MIHPHIADALKVPDLVRLNDDLVLIRFESMKIYSALAAVRHLLERGTIRPGQTLIDSSSGIYAYALALACHRYGMRCHVVASTTVDTTTRAQLEILGATVEQVRPSRNLKLDQELRVRRVREILADHPDWHWMRQYHDDVHYLGYQEVADRITTAFPSTPLTVVGGVGSGASTGGLVERLRATDPSVRLVGVQPFGSVTFGSQAHHDPEAIIAGIGSSIVFDNVRHHLYDAVHWLDFTHAMSGTIALLRERAVFAGLSTGAGYLAATYEARRHPDRLHLVIGADTGHRYVERVFARHTEALDPAPLKPVEVSAPEEMSMPWSRMAWRRTACPAGRKERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2X3</accession>
    <name>Q9F2X3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4588</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628750.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029746.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4588"/>
    <dbReference type="GeneID" id="1100028"/>
    <dbReference type="KEGG" id="sco:SCO4588"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4660"/>
    <dbReference type="eggNOG" id="ENOG503370G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023624_1_0_11"/>
    <dbReference type="OMA" id="HELIALW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="508" mass="53194" checksum="6D2B41146F56CEAB" modified="2001-03-01" version="1">MRIGSERRDSKQVHDRHDRLWTAGNGNRRRKPPMSGGTMSRLGRDKQREHERAEGSPGPATTPIDVHVPDGDSGVRGASVDGSRVVAAPGEEIQNAVLNRLHRLALAAGRPVLATIHDRRLGYSVPLRVDPDGSSHLAAEPVPTAAEAAREGAREEAAVVAPVEAPARYDRPTHVLRSVVPARDGTPTFPLPAVSGTERERSGSASAPTFTLRALPEPARGTPPGTVAPPTGAFGPPPRMDGAATTGTARDAAPRPTYGPFAAPGPIPAPEPVPEPVPGPLLERVLELKPEPEAAPAPAPSPAPTPTPAPAPAPKPIPDPYSDPDPKPTPARGFDAVAEAVLGDAPLTAPGDATTPALLAEPTARINEAVKEGRTEAAARLAEQTVTEASRTLGPEHAEVLRLRELTAYIAYLSGDPDRAFQLSLDLARIHRRSGDAESAYGNVQSAATAWRAVRDPARGLELGNDLVGLWSELAAEDGPAAEDAEELESARTRMGRLTERAARAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Z5</accession>
    <name>Q9F2Z5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4352</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628522.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974629.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4352"/>
    <dbReference type="GeneID" id="1099792"/>
    <dbReference type="KEGG" id="sco:SCO4352"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4420"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F2Z5"/>
    <dbReference type="OMA" id="QQGWAYY"/>
    <dbReference type="PhylomeDB" id="Q9F2Z5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="36117" checksum="5733CFEF9F7BEEA5" modified="2001-03-01" version="1">MKYTQLGRTGLKVSRLVLGTMNFGPQTDESTSHDIMDAALDAGLNFVDTANVYGWGENKGRTEEIIGTWFAQGGGRRDRTVLATKVYGNMAGDGDVWPNHDKLSAVNIRRAVDASLKRLQTDYIDVYQFHHIDRSTPFEEIWQAIDVLVQQGKILYAGSSNFPGYKIAQANEIAARRGGTIGLVSEQCLYNLAERRAEMEVIPAARDYGLGVIPWSPLHGGLLGGVIKKEATQGRRASGRAADALKDTKTREQIQAYEDLLDKHGLQPGEAALAWLLTRPGVTGPIVGPRTQEQLDSALRALELELSEELLTSLDEIFPGPGPSPEAFAW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F305</accession>
    <name>TRMB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">SCO4111</name>
        <name type="ORF">SCD17A.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC08407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974862.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F305"/>
    <dbReference type="SMR" id="Q9F305"/>
    <dbReference type="STRING" id="100226.SCO4111"/>
    <dbReference type="GeneID" id="1099548"/>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.4171"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_0_1_11"/>
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    <dbReference type="OMA" id="PDPWHKS"/>
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    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
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    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
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    </dbReference>
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        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000171401" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="271" mass="29912" checksum="8E9A7A05BA6E2829" modified="2001-03-01" version="1">MSDSHHTPEAASASLRHVRAKGEPRFPDGPKADPAGSHFERRIRSFQPRRSRVTAGQADALQRLWPLWGLDIDGRRVVDLAELFGNARPVVLEIGFGMGETTARMAAADPDTNILAADVHTPGQGNLLGLAERQELPNIRVANGDAIILLREMLAPGSLAGLRVYFPDPWPKKRHHKRRLIQPEFLTLAATRLAPGAVVHCATDWEPYAEQMLDVLTAHPDFENTVPGGGFAPRPEHRPLTRFEGQGLDKGHVVNDLLFRRVQHKEPPPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F368</accession>
    <name>Q9F368_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4420</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC08429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO4420"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="103" mass="11387" checksum="55C2B80589EB75B5" modified="2001-03-01" version="1">MRMRMRMRMRMRAGMDAGHNVGRAGGCSPSGVVTVLNFEALDVVPVRPRGRGTVAEFERSADGGARLELRRCRAAEMQSWGDAELGRCRAAEVRRAANAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3H5</accession>
    <name>Q9F3H5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2806</name>
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    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2806"/>
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    <dbReference type="KEGG" id="sco:SCO2806"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2864"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_13_1_11"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC10115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21823" checksum="4A95D408A3D29CC8" modified="2001-03-01" version="1">MAPRILLARHGQTEWSLSGRHTGRTDVPLLEEGRRGAKLLGERLHRAPWDGLDGVEVRTSPLVRASETCELAGFGERARAWDTLMEWDYGAYEGMTPEQIQAVRPGWLIWRDGAPEGEGVADVTARADEVVAWAREAERDVLVFAHGHVLRAIGARWLGLPVSFGARIRLSPTSLSVLGWAYGEPAVESWNDLGHLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L4</accession>
    <name>Q9F3L4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5250</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629396.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973720.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5250"/>
    <dbReference type="GeneID" id="1100691"/>
    <dbReference type="KEGG" id="sco:SCO5250"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5335"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_11"/>
    <dbReference type="InParanoid" id="Q9F3L4"/>
    <dbReference type="OMA" id="WRVFGTT"/>
    <dbReference type="PhylomeDB" id="Q9F3L4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC05969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="386" mass="40235" checksum="B326E1D039A92C3E" modified="2001-03-01" version="1">MTETRRGATATCRPTGAPERHGPIGTQREKEPGEPSDGQGEAVVEGHEAALLLSESRASVDPELRSAIATLPESMRRVALYHFGWQHADGTPAAGNAGKAIRPALVLTAAAALGGPGARAAAVRAAAAVELVHNFTLLHDDVMDRDATRRHRPTAWTVFGDADAILAGDALQALALRLFAADPHPASAAAATRLADCVMELCEGQHADTAMERRPPDEVTLDETLVMAEAKTGALLGCACAVGALYAGAATEDVEALDAFGREAGMAFQLIDDVIGIWGDPRHTGKPAGADLAARKKSLPVVAALTSGTPAAAELAELYTGPYDENKEDLERTALAVERAGGRDWAQAQAADRMARAMQELARAVPEPEAAGGLLALAEFVTRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3M7</accession>
    <name>Q9F3M7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7661</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631701.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031810.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7661"/>
    <dbReference type="GeneID" id="1103099"/>
    <dbReference type="KEGG" id="sco:SCO7661"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7780"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F3M7"/>
    <dbReference type="OMA" id="EIFAAHW"/>
    <dbReference type="PhylomeDB" id="Q9F3M7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325316" evidence="2">
        <location>
            <begin position="29"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RibD_C" evidence="3">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC16994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="23246" checksum="588BBC3951CED2BC" modified="2001-03-01" version="1">MRSTRRRRERTMRKIIVCTFLTLDGVMQAPGGPDEDAESGFEHGGWQKPVDDDEVGTAIAGWYEDSDAMLLGRKTYDIFASYWPTADPDNPFTHRMNSMHKYVASRTLTSLDWQNSTLLEGDTVDAVRRLKASDGGNLNVVGSGDLAQTLMRHGLVDEYRLTIHSVIIGTGKRLFADGAIPTALEPVSVSVTKGGTVVGVYRPSGAPSYDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBY9</accession>
    <name>Q9FBY9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2012-08" db="PDB data bank">
            <title>DyP-type peroxidases from Stretptomyces and Thermobifida can modify organosolv lignin.</title>
            <authorList>
                <person name="Lukk T."/>
                <person name="Hetta A.M.A."/>
                <person name="Jones A."/>
                <person name="Solbiati J."/>
                <person name="Majumdar S."/>
                <person name="Cronan J.E."/>
                <person name="Gerlt J.A."/>
                <person name="Nair S.K."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) IN COMPLEX WITH HEME</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631251.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031498.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="PDB" id="4GU7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B/C/D=1-316"/>
    </dbReference>
    <dbReference type="PDBsum" id="4GU7"/>
    <dbReference type="SMR" id="Q9FBY9"/>
    <dbReference type="STRING" id="100226.SCO7193"/>
    <dbReference type="GeneID" id="1102631"/>
    <dbReference type="KEGG" id="sco:SCO7193"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7292"/>
    <dbReference type="eggNOG" id="COG2837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044178_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBY9"/>
    <dbReference type="OMA" id="CAEPNLH"/>
    <dbReference type="PhylomeDB" id="Q9FBY9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Heme</name>
            <dbReference type="ChEBI" id="CHEBI:17627"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
            <note>axial binding residue</note>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4GU7"/>
        </source>
    </evidence>
    <sequence length="316" mass="34147" checksum="CC3369AEB02A8820" modified="2001-03-01" version="1">MGGEVEEPEPQMVLSPLTSAAIFLVVTIDSGGEDTVRDLLSDVASLERAVGFRAQPDGRLSCVTGIGSEAWDRLFSGARPAGLHPFRELDGPVHRAVATPGDLLFHIRASRLDLCFALATEIMGRLRGAVTPQDEVHGFKYFDERDMLGFVDGTENPTGAAARRAVLVGAEDPAFAGGSYAVVQKYLHDIDAWEGLSVEAQERVIGRRKMTDVELSDDVKPADSHVALTSVTGPDGSDLEILRDNMPFGSVGREEFGTYFIGYARTPEVTETMLERMFLGTASAPHDRILDFSTAVTGSLFFTPAADFLEDLPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC41</accession>
    <name>Q9FC41_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative marR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7042</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631104.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972102.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7042"/>
    <dbReference type="GeneID" id="1102480"/>
    <dbReference type="KEGG" id="sco:SCO7042"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7146"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_2_4_11"/>
    <dbReference type="InParanoid" id="Q9FC41"/>
    <dbReference type="OMA" id="VHARTMC"/>
    <dbReference type="PhylomeDB" id="Q9FC41"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14883" checksum="1DF0496F496877D4" modified="2001-03-01" version="1">MGARTAGAPLEERWRDILSVHARTMCEIDRALHPHGLGASDFEVLDLLVTGAPDDGDRCRVQNLVGRVHLSQSALSRLIARLEKDGLVRRSMCAEDRRGVYVTPTSRGRELHAEILPLQRAALARTLGDDEGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL1</accession>
    <name>Q9FCL1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5177</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629325.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973799.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5177"/>
    <dbReference type="GeneID" id="1100618"/>
    <dbReference type="KEGG" id="sco:SCO5177"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5260"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060605_2_0_11"/>
    <dbReference type="InParanoid" id="Q9FCL1"/>
    <dbReference type="OMA" id="RPDPHCL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="27165" checksum="17E1321CA63CE061" modified="2001-03-01" version="1">MSYLTSTKAGVASTGVHTGLGVPGLAHPLLAPDEWAGLTCPGTPLHWVVLNIADGPGAHPDPRCLEAAGRLRNAGIRVLGHLDTAYGARSLGEQISDARRYLDWYQVDGFLLAHCPSDRAALPEVRRTVTTLRAIRDDAHIVLGHGTHPCPGYAENADQLVTFSGTWADYRWSQAAEWSADYPPERFCHFVHGLPRGHLEEALRIARWQGAATICFTDRTDHGGRADPWETMPGYWDEIVSRVGTGVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3G4</accession>
    <name>Q9K3G4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1277</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625564.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977554.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1277"/>
    <dbReference type="GeneID" id="1096700"/>
    <dbReference type="KEGG" id="sco:SCO1277"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1276"/>
    <dbReference type="eggNOG" id="ENOG5030PX2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123997_0_0_11"/>
    <dbReference type="OMA" id="NMADSGK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB99157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="22951" checksum="EE32ABD76146881B" modified="2000-10-01" version="1">MGNSKNVQDIFKDLVGDMTDSWKEAFDDLLNRDDDSGSSRGSGSSRDSGNAVSTLAGLPPNALAALAGAVNPATALAGVTNPLAALGGIGAAGNPLAGLAAGAAGPLGNIAGAAQNPLAALTGAAGGGNPLAAALGGAGNPLAALGGAANPLAAVGGAAGALGGLGQLAGGLGHAASGAGDLMALPAQLTQLLQVLPKLLEAVQGLQNLTNLPAQAGQQGLAALQGLTGQQGPGGKPSQGGQSSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3T6</accession>
    <name>Q9K3T6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative fatty acid desaturase (Membrane)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3128</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627345.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975685.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3128"/>
    <dbReference type="GeneID" id="1098562"/>
    <dbReference type="KEGG" id="sco:SCO3128"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3192"/>
    <dbReference type="eggNOG" id="COG1398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K3T6"/>
    <dbReference type="OMA" id="SCGESWH"/>
    <dbReference type="PhylomeDB" id="Q9K3T6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="63"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB95921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="37734" checksum="50A17D918BD78348" modified="2000-10-01" version="1">MTTSSDVIPDAPQPAGDAAGPSATLGGEQKRSIEQITLLLFITLPFLALVAAVPLAWGWGVSWLDLGLLVFFYFLGCHGITIGFHRHFTHGSFKAKRPLKIALAIAGSMAVEGPLVRWVADHRKHHKFSDDEGDPHSPWRYGETVPALIKGLWWAHIAWMFDEEQTPQEKYAPDLIKDPALRAVSRQFILWTVVSLALPALIGGLVTMSWWGAFTGFFWGSLVRVALLHHVTWSINSICHAVGKRPFKSRDRSGNVWWLAILSCGESWHNLHHADPTSARHGVMRGQLDSSARLIRWFEQLGWAYDVRWPSRSRIDSRRNTDQDGARRRKETAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K404</accession>
    <name>Q9K404_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1329</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625614.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977499.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1329"/>
    <dbReference type="GeneID" id="1096752"/>
    <dbReference type="KEGG" id="sco:SCO1329"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1332"/>
    <dbReference type="eggNOG" id="ENOG5031XDE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2636371_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="8417" checksum="A965937A3BDBC987" modified="2000-10-01" version="1">MTIWRKLLTALKDDRLDEAERDVLLAQAAVRIAADRCAPTRRPTADEVVTVAREEFAALIDPGQARAALATWGRGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K415</accession>
    <name>Q9K415_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1084</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625378.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977746.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1084"/>
    <dbReference type="GeneID" id="1096507"/>
    <dbReference type="KEGG" id="sco:SCO1084"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1081"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091304_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K415"/>
    <dbReference type="OMA" id="DWCGPCA"/>
    <dbReference type="PhylomeDB" id="Q9K415"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13286" checksum="6E1F2490B6F24FCD" modified="2000-10-01" version="1">MPRWRRNGGALVRGQDDGKRSEGTAVRVDAADLGAELGPRATLVQFSSAFCAPCRATRRVLGEVAGLVPGVAHVEIDAEGHLELVRALDVLKTPTVLVLDADGRVVRRATGQPRRADVIAALGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C4</accession>
    <name>Q9K4C4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5387</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629526.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030216.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5387"/>
    <dbReference type="GeneID" id="1100827"/>
    <dbReference type="KEGG" id="sco:SCO5387"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5468"/>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018922_0_0_11"/>
    <dbReference type="OMA" id="QAYFHHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="874" mass="89269" checksum="531A98230E14DC2D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXS6</accession>
    <name>Q9KXS6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628487.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029574.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4315"/>
    <dbReference type="GeneID" id="1099755"/>
    <dbReference type="KEGG" id="sco:SCO4315"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4383"/>
    <dbReference type="eggNOG" id="COG3142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050555_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KXS6"/>
    <dbReference type="OMA" id="CRWTFHR"/>
    <dbReference type="PhylomeDB" id="Q9KXS6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="23918" checksum="E898B98E9571E7D7" modified="2000-10-01" version="1">MSKRAVLEVIALDAEDAVAAQAGGADRLELVTDMAADGLTPSAATVAAIRAAVDIDVRVMLRLADGFAAGDVERLTRVARDMREAGATQFVLGFLDAQGDVDLGAVERIAEVLDGCRWTFHRAIDRAASRDALRKQLADFPGLDTYLTAGAAGGVDDGLSVLLAEARRRGEPGYEQQLLVGGGLRLDHVPGLLDAGIDGFHIGGAARPAGWAGPVSADAVSQWRRVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXZ3</accession>
    <name>Q9KXZ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC-transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2422</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626666.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976384.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KXZ3"/>
    <dbReference type="STRING" id="100226.SCO2422"/>
    <dbReference type="GeneID" id="1097856"/>
    <dbReference type="KEGG" id="sco:SCO2422"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2463"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KXZ3"/>
    <dbReference type="OMA" id="GMVFQYS"/>
    <dbReference type="PhylomeDB" id="Q9KXZ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB92896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="36701" checksum="5F1407EAB4AAC3E8" modified="2000-10-01" version="1">MASAGGDMGIEVVVEGLTKSFGKQSIWRDVSLTLPAGEVSVMLGPSGTGKTVFLKSLIGLLKPEKGRVLINGVDMVNSPERDIYETRKLFGLMFQDGALFGSMSLFDNIAFPLREHTRKKESEIRRIVMERIEVVGLLGAEGKLPGEISGGMRKRAGLARALVLDPQIILCDEPDSGLDPVRTAYISQLLIDLNAQLDATMLIVTHNLDIAATVPDNMGMLFLRQLVTFGPREVLLTSDEPVVAQFLGGRREGPIGMSEEKDAATLAAEADAAPAAPAAPRVIVPQLEPSPGLPPRRAVARRRKRVMGMIDTLPPAARSAIRDTYARDSEAATLPMPAAGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY89</accession>
    <name>Q9KY89_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5013</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629165.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030003.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5013"/>
    <dbReference type="GeneID" id="1100454"/>
    <dbReference type="KEGG" id="sco:SCO5013"/>
    <dbReference type="eggNOG" id="ENOG5031WU6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110728_0_0_11"/>
    <dbReference type="OMA" id="CWRADQL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21097" checksum="DE06826B50468C15" modified="2000-10-01" version="1">MYSSQRDAGQAFPIYITVVAGLLFLALAYFAVGQAATNRNGAQTAADAAALAAAQETRDQLAGEWVDNLSDPASWERIFDGLGTGPSDSCWRASELAAQNDAQVDSCEPDGPLGFKVEVTSDDPVGDSIVPGTEDKHAQASATAVIEPNCEFELPDGDGKDDVLPRITCDDQDWELDPEDLPELPKPQDLFDVHLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ35</accession>
    <name>Q9KZ35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MarR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7097</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631158.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031427.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7097"/>
    <dbReference type="GeneID" id="1102535"/>
    <dbReference type="KEGG" id="sco:SCO7097"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7197"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_5_11"/>
    <dbReference type="InParanoid" id="Q9KZ35"/>
    <dbReference type="OMA" id="SITTRDW"/>
    <dbReference type="PhylomeDB" id="Q9KZ35"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="21881" checksum="071A1314BC8C501A" modified="2000-10-01" version="1">MNDPCVSPNLSPSAEESAPRPAVQPCPDRGDSVDAMLRQWEERRPGVDVSSSEVLARLLRAARLAEELFEERLRRQPGRTITNVGDFDLLQTLRRAAPGHALTPGQLMRHLVVSSAGLSGRLNRLERDGWIVRTASPDDRRRSLVSLTVQGREEFDRRLEGHLAVERELLSVLDARERVVVVGALRKLLLVLEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZB8</accession>
    <name>Q9KZB8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6971</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631037.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031346.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6971"/>
    <dbReference type="GeneID" id="1102409"/>
    <dbReference type="KEGG" id="sco:SCO6971"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7070"/>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098653_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZB8"/>
    <dbReference type="OMA" id="ARHGWIM"/>
    <dbReference type="PhylomeDB" id="Q9KZB8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="28535" checksum="292C18E795EF8756" modified="2000-10-01" version="1">MRTIHVIGIGAGDPEQLTLQAVRALRGTDVFFVLDKGEAKSDLVRLRRDMLEAHVPEGTYRVAEARDPERDRSAGGAAYSPAVGDWRSARAGIYERLIAEELGEDETGAFLVWGDPALYDSTLGILEEILERGSVAFEYDVVPGISSVSSLVARHRTGLNRVARPVQITTGRRLAEGFPEDADDVVVMLDAHQAFRRYADQDIDIYWGAYLGTPDEILDSGPIAEAAPRIERLRAEARERKGWIMDTYLLRRNPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZG9</accession>
    <name>Q9KZG9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6983</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631048.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031354.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6983"/>
    <dbReference type="GeneID" id="1102421"/>
    <dbReference type="KEGG" id="sco:SCO6983"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7082"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_17_2_11"/>
    <dbReference type="InParanoid" id="Q9KZG9"/>
    <dbReference type="OMA" id="LEKQMWG"/>
    <dbReference type="PhylomeDB" id="Q9KZG9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14670" checksum="E6FD6F4DFF59412B" modified="2000-10-01" version="1">MSSRLNPYLSFDGDARQAMEFYGQVFGGTPALNTFGSAGMPDPAYTDKIMHGMLETPSGFTLMGADTPPGMEYTPGNTFAVSLSGDDATELRGYWEKLSAGGSVAVPLEKQMWGDVFGMCTDRFGVTWMVNISEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZH4</accession>
    <name>Q9KZH4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631043.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972167.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6978"/>
    <dbReference type="GeneID" id="1102416"/>
    <dbReference type="KEGG" id="sco:SCO6978"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7077"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_11"/>
    <dbReference type="InParanoid" id="Q9KZH4"/>
    <dbReference type="OMA" id="AIVKQGP"/>
    <dbReference type="PhylomeDB" id="Q9KZH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="34096" checksum="4E3A3F7163C34FB8" modified="2000-10-01" version="1">MAESVPRFDLITMGRIGVDLYPLQTGVPLAEVETFGKFLGGSASNVAVAAARLGRATAVITRTGDDPFGGYLHDALKEFGVDDRWVTPVAAYPTPVTFCEIFPPDDFPLYFYRRPKAPDLEIHPEELDLDAIRAASIFWMTGTGLSEEPSRTATLSALAHRAKSGTTVFDLDWRPMFWADPDQARPYYAEALAHATVAVGNLDECEIATGVREPRACAEALLAAGVELAVVKQGPKGVLAAHRDGRSAEVPPVPVEVVNGLGAGDAFGGSLCHGLLSGWELERIMRYANAAGALVASRLACSSAMPTEAEVDDLLARATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZI7</accession>
    <name>Q9KZI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977673.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1158"/>
    <dbReference type="GeneID" id="1096581"/>
    <dbReference type="KEGG" id="sco:SCO1158"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1156"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KZI7"/>
    <dbReference type="OMA" id="QWYDNEA"/>
    <dbReference type="PhylomeDB" id="Q9KZI7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14481" checksum="2A1C879160ADFBB3" modified="2000-10-01" version="1">MTDDITGGDREGPGSQWYDNEAGPLVRPYAMTGGRTRPGPAGARFDLIALVTRAVGAPDADDTVLGPEHRTLIDLCRTETQSVAELAADADLPVGVVRVLLGDLAELGCVTVSRPVPPAQLPDERILREVIDGLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZU0</accession>
    <name>Q9KZU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4162</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628339.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029476.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4162"/>
    <dbReference type="GeneID" id="1099602"/>
    <dbReference type="KEGG" id="sco:SCO4162"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4227"/>
    <dbReference type="eggNOG" id="ENOG5033RA4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036486_0_0_11"/>
    <dbReference type="OMA" id="DERMYGL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="437" mass="45168" checksum="87D3B2F1E81B39B6" modified="2000-10-01" version="1">MTDQPHQQYDPNQPYDPGRQYDPGRQYDPGRQYDPNQPYDPGRQYGRDQQYEGYDAQAWPGQQPYQSHQGYGEPQPDPNAGQYTQQWQGQTWETQVQPPVSAEETAYLPPLAQPQPEPQPYASQGYGQPQPQPQQYAPQPQPQPQPQPAPAPYAHVTAAPSPAPTPTPAPSTSGDPGYGPATVAGNTRITDAQRARAEGRSPIIDPGMQPAGLTALLGLLLSGAAALGTYALLVPVVVLQAVTAAGWFRLNGMWPARQGIALGFAGALAADAALLVSDRSPAAILGTLGVWVLLSLVLQLRSHADPDERMYGLMATIAAAALAVVAGGYLAADADAVTVGGIAVAVAAVARALPLPTPASVVVALLAAAGAGIAAGSMTDFGASGALLGAGAAVCALIGLRVAAYDYPSRFVHFTAGVALPLAAAAPAVYLLGRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0A1</accession>
    <name>Q9L0A1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha</fullName>
            <ecNumber evidence="8">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">SCO2445</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="8"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028357.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L0A1"/>
    <dbReference type="STRING" id="100226.SCO2445"/>
    <dbReference type="GeneID" id="1097879"/>
    <dbReference type="KEGG" id="sco:SCO2445"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2486"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0A1"/>
    <dbReference type="OMA" id="WATPDSY"/>
    <dbReference type="PhylomeDB" id="Q9L0A1"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="237"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAB86110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="458" mass="47180" checksum="E5E4086CB29B69C1" modified="2000-10-01" version="1">MTERLTAREFLALVTDDATFSELPHADGPWRPDGPLGWPGYDASRARAAERTGEAESVVCGTGLVEGTRAVLVSFEFGFLGGSLGHRTGDRLEAAYAYAREHRLPVVPLVATGGSRMQEGMLALTQLQRVARQSALTRAAGLAQIAVVRDPATGGGWATLGAGADVVLALPGAQVGFAGSRVRPPDADPAAYTAEAQVAAGSADAVVPPGELRATLGRWLRLLTAPSGGPAPVPEPLGARDLPAGGWEAVRRARDPGRPRAGAYLDAYFTDRVALSGDRCGGRDPEGMLCGFGSHAGRTVAYAAQTGTATRPAGYRTATRLIHLADRLGIPVLTLVDTPGAANDAEAERAGAGPAIADLFGAVASARTPVTTLVIGEGGSGGALALAAPGSTWATPDSYFSVIAPEHAAAILKRPPAEVEATAGQLRLRPQDLAALGVIRTSEQLFPGTGDRRSEERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0B0</accession>
    <name>Q9L0B0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2436</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626679.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028351.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2436"/>
    <dbReference type="GeneID" id="1097870"/>
    <dbReference type="KEGG" id="sco:SCO2436"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2477"/>
    <dbReference type="eggNOG" id="ENOG5033IXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042795_2_1_11"/>
    <dbReference type="OMA" id="IHNALGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB86101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="394" mass="41182" checksum="B61CFC9792FB8B04" modified="2000-10-01" version="1">MNSLINYLSCAALWLGLAVRAPDLLRHRHDPYLRAICAVLGLAGLCFALGAPPTVGAVNRLSGVPNLAAPITYAAITGYCAASQVLVVHWRGGPRVRRTARRWTLAYAVVVLGIALTFALGEAPVERRTDLDTYYATTPFIAQMIVLYLVAHLTAATVTTVSALRWARQVRGGLRAGLTLIGAGSLCGAGYSATKLVAVGARWSGRDWSALGTTVSPAAAGLGALLVVVGVLVPLVTPRVAEWRRAGRAYARLGPLERALDDLLVRRALRLPRPRSASPATLLMWRRTSIHNALGHLDAYCDRDLYDRTRADTLTATGDPALAGAHAWAAVIVDALRHEAGAGEAPPPAAGTGRPLAPSPDPAALARISDVLAGAVRVPAASPAPSGRTTAGTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-10" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0D4</accession>
    <name>RS3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">SCO4708</name>
        <name type="ORF">SCD31.33</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628867.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974261.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0D4"/>
    <dbReference type="SMR" id="Q9L0D4"/>
    <dbReference type="STRING" id="100226.SCO4708"/>
    <dbReference type="GeneID" id="1100149"/>
    <dbReference type="KEGG" id="sco:SCO4708"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4779"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_11"/>
    <dbReference type="InParanoid" id="Q9L0D4"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="PhylomeDB" id="Q9L0D4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130206" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="277" mass="30274" checksum="5831536E64018135" modified="2000-10-01" version="1">MGQKVNPHGFRLGITTDFKSRWYADKLYKDYVKEDVAIRRMLTSGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADKIRGQLEKLTGKQVQLNILEVKSPETDAQLVAQAVAEQLSSRVSFRRAMRKSMQGTMKAGAKGIKIQCGGRLGGAEMSRSEFYREGRVPLHTLRANVDYGFFEAKTTFGRIGVKVWIYKGDVKNIAEVRAENAAARAGNRPARGGGNDRPARGGRGGERRGRKPQQQSAPAAEAPKAEAPAAAAPAESTGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0W9</accession>
    <name>Q9L0W9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627926.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029196.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3735"/>
    <dbReference type="GeneID" id="1099171"/>
    <dbReference type="KEGG" id="sco:SCO3735"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3796"/>
    <dbReference type="eggNOG" id="ENOG502ZCXU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130441_0_0_11"/>
    <dbReference type="OMA" id="DYLGPPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="16114" checksum="F48AFC785A6141BB" modified="2000-10-01" version="1">MLRPGADFLGPPPGRYEAIRRAASRRRLLRAAAGAAATAAAAALIALPLNLAAPAPPARPTPPLAPAPAAPTPEATPSPAPPSESTRAPDTGPALPTGESAPPGATPSPSEPSPSTPSSEPSAEPSDPPVRQAPTNAPGTVVPTPSAHGPAEQGGPAVTDGTAATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0X6</accession>
    <name>Q9L0X6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3728</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627919.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029192.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3728"/>
    <dbReference type="GeneID" id="1099164"/>
    <dbReference type="KEGG" id="sco:SCO3728"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3788"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095351_0_0_11"/>
    <dbReference type="OMA" id="HRWIANG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="26854" checksum="0CCC7210AEDF5B4C" modified="2000-10-01" version="1">MGTDGFATWTRRFEDERERRAAQGDPDWERGAVLHRAVWAGIQRFQVGEDGDGANLVAKAEEAGDADYARAVRLFVAEEQNHARLLARLLAAGDRPALSGHWSDTVFVRLRRLLGLRTELLVLMIAEVVALRYYRALRDGTDDALTSEVAGRILADERRHVPFHCERLHHSLAELPAVTRRPVMVLWRLLLLAATVVVAADHGAGLRRLGVGRRRFAADVMASASEVAEAVLTPRPDAWSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L121</accession>
    <name>Q9L121_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7439</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631488.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031666.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7439"/>
    <dbReference type="GeneID" id="1102877"/>
    <dbReference type="KEGG" id="sco:SCO7439"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7549"/>
    <dbReference type="eggNOG" id="COG3340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067063_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L121"/>
    <dbReference type="OMA" id="LFPMPNV"/>
    <dbReference type="PhylomeDB" id="Q9L121"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26231" checksum="B901487D58902E4D" modified="2000-10-01" version="1">MTAPQPTILATSGGHRAGGRTMVAFDALVHHAVDLSGAHGRRPRVLYVGTAIGDAEHFTARMTEAARVAGFDLTPLHLFPMPNVEDVEETVLAQDVVWVMGGSVANLLAVWRVHGLDRVMRKAWEAGVVLSGVSAGSLCWFRGGATDSFGPELRPITDALDFLPYGNGVHYDVDPGRRPLIHRLVADGTLPTAHCTDDGVGLVYRGTELAEAVTEVPGKGAYVVARDGDTAVEERIEPRELPGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L164</accession>
    <name>Q9L164_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7451</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="398" mass="43112" checksum="8D2705D9C03791DC" modified="2000-10-01" version="1">MTTTSTPASGPLSSEALASGAIAPEPLTRQLSHQVSQSVFDGSRLRVVLLVEVYDGAQQQFLETYENLRSHVESVPGHLGEQLCQSIENPSQWLITSEWESAPPFLNWVSSEEHVRMVKPLHSCVRDTRSLRFHVVRETGHPSTGADPARGGLQAAPRVGDGVIRHALTFTVKPGSEEAVGKILADYASPEPQVDDTTRLCRTSLFLHGNRVVRAIEVRGDLLAALRHVAEQPEVRAVEEAINPYLEQDRDLGDPESARVFYTRAALPAVHHVTAGEGQDGAQRHALSYPARPGCGMRLAQLLAERDEAAARDPRSPVLCSTIFQRDDVVVRLVDVRGDLHEGDPAVTLGLPDPGRVSELTTLLDGFTDAGSPTGGGLVRALEGARMELVTDRRAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1F5</accession>
    <name>Q9L1F5_STRCO</name>
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        <submittedName>
            <fullName evidence="11">Putative ABC transporter</fullName>
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    <gene>
        <name evidence="11" type="ordered locus">SCO5450</name>
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    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
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            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO5450"/>
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    <dbReference type="InParanoid" id="Q9L1F5"/>
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    <dbReference type="PhylomeDB" id="Q9L1F5"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="224"/>
        </location>
    </feature>
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            <end position="348"/>
        </location>
    </feature>
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            <begin position="387"/>
            <end position="621"/>
        </location>
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        </location>
    </feature>
    <feature type="binding site" evidence="6">
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            <begin position="420"/>
            <end position="427"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB76004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="627" mass="66951" checksum="2966C4829D27483E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1L1</accession>
    <name>Q9L1L1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AfsR-like regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="1100873"/>
    <dbReference type="KEGG" id="sco:SCO5433"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5515"/>
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    <dbReference type="InParanoid" id="Q9L1L1"/>
    <dbReference type="OMA" id="VALCHEC"/>
    <dbReference type="PhylomeDB" id="Q9L1L1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="596"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB72409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="761" mass="81400" checksum="4DBBAC753A158696" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L211</accession>
    <name>Q9L211_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO6821</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630893.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031208.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6821"/>
    <dbReference type="GeneID" id="1102260"/>
    <dbReference type="KEGG" id="sco:SCO6821"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6930"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081279_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L211"/>
    <dbReference type="OMA" id="PFLGTCG"/>
    <dbReference type="PhylomeDB" id="Q9L211"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="26059" checksum="46B59D7AE73A8583" modified="2000-10-01" version="1">MSVSARPRLALVGDRGNHDEPSHPKIDAMREQWDLTTEWIPTTDIHDVSVLDGFDGIWVVPGAPYFNQKGVHVAVRHARENGLPFLGTCGGFFSALIEHAQNVLHLPEAAGVDEDPEKLMPLVTPLKCSFRGEKAPLTVMENSRLAGIYGTTEVEEIFHCDYGLTDTFMNAANQGSLRLSAWDSDGAPRALEITGHPFFLGSLFQPELSSAPGSEHKILKAFLAAVSAKADTDALPMPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L238</accession>
    <name>Q9L238_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6794</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630866.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031188.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6794"/>
    <dbReference type="GeneID" id="1102233"/>
    <dbReference type="KEGG" id="sco:SCO6794"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6904"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017312_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L238"/>
    <dbReference type="OMA" id="ETHIRPQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="290"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="650" mass="67761" checksum="8F8074928397BC5B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2D4</accession>
    <name>Q9L2D4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2485</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028380.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2485"/>
    <dbReference type="GeneID" id="1097919"/>
    <dbReference type="KEGG" id="sco:SCO2485"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2527"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_0_11"/>
    <dbReference type="InParanoid" id="Q9L2D4"/>
    <dbReference type="OMA" id="YAYGFIM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB69773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="25996" checksum="DA0F43E1197BACE1" modified="2000-10-01" version="1">MPDISLTTVVLLCLAALAAGWIDAVVGGGGLLLLPALLLGLPSGTPAAHALGTNKAVAIVGTTGAAVTYARKAPVDVRTAVRIGLAALAGSSGGAFFAAGMSTEVLKPVIMVVLLAVAAFVIFRPAFGTAPATGPATRRRILAAIGLAGLGIGFYDGLVGPGTGTFLVLALTALLHLDLVTASATAKIVNCCTNAGALATFAWQGAVLWQLAVPMAAFNLAGGMFGAHTALKRGSGFVRVVLLTVVFALVANLAWEQWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2I8</accession>
    <name>Q9L2I8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0721</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625026.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027316.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0721"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="GeneID" id="1096144"/>
    <dbReference type="KEGG" id="sco:SCO0721"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.710"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_2_11"/>
    <dbReference type="InParanoid" id="Q9L2I8"/>
    <dbReference type="OMA" id="EAYCIPF"/>
    <dbReference type="PhylomeDB" id="Q9L2I8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="5">
        <location>
            <begin position="327"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="6">
        <location>
            <begin position="704"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="592"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="792" mass="87250" checksum="76E24E523D18992E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2K0</accession>
    <name>Q9L2K0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched-chain amino acid ABC transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0708</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625013.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027308.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0708"/>
    <dbReference type="GeneID" id="1096131"/>
    <dbReference type="KEGG" id="sco:SCO0708"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.695"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L2K0"/>
    <dbReference type="OMA" id="VAGIMWG"/>
    <dbReference type="PhylomeDB" id="Q9L2K0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB69680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="30175" checksum="E52AD030AB96B6E8" modified="2000-10-01" version="1">MTGFLDSLLGGLALGSVYALIALGFVTIFKASGVLSFTHGSLLLLGGYLVAVLHDDLGFAGALAVAVLVTAAVAGALDRLVLQRVGGSDPHAAHVQTIVTIGVDIVLVTDLARRIGGDLLPLGDPWGSAVTDLGPVTVADSRIAAILVSAVAIGGAFALFRYTPWGLSLRAAAEDREAAALMGVRLTRVRTAAWCLAGALAALAAVFLVAFPAPGLERTTGQIALKAFPAAILGGMTSPVGALVGSMLIGLTEAFVAGYQSDLHVLGEGFGDVAPYAVMVLVLLVRPAGLFAAKGAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCU7</accession>
    <name>Q9RCU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable ECF-family sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0864</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB65645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625164.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027400.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0864"/>
    <dbReference type="GeneID" id="1096287"/>
    <dbReference type="KEGG" id="sco:SCO0864"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.856"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_5_11"/>
    <dbReference type="InParanoid" id="Q9RCU7"/>
    <dbReference type="OMA" id="PRIAHGA"/>
    <dbReference type="PhylomeDB" id="Q9RCU7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB65645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21664" checksum="6A39EF8175FFE553" modified="2000-05-01" version="1">MTPALPTATDDTVTAWALAAAAGDSEAVDRFVRELQRDVRRYVAYLADDVQAADDLTQDTFLRALTALPRFEGRSSARVWLLSIARRAVVDSLRRAACRPRTACTDDWQAAAERAQPTGLPGFDEGIALWELVDSLPGERREAFVLTQLLGLPYAEAAEMSRCPVGTVRSRVSRARTALAEWAADESVPRHPVERAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD43</accession>
    <name>Q9RD43_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0640</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624950.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027265.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0640"/>
    <dbReference type="GeneID" id="1096063"/>
    <dbReference type="KEGG" id="sco:SCO0640"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.624"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119090_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RD43"/>
    <dbReference type="OMA" id="MADERHA"/>
    <dbReference type="PhylomeDB" id="Q9RD43"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="15435" checksum="4B4F53736BAB1BCC" modified="2000-05-01" version="1">MSLRKTIGGGRRRAVTDDRRPRRRGQGELEALVLSALREADGPATAGWVQERLGGDLAYTTVITILTRLLEKGAVSRERAGRSFAWTPAADQAGLAARKMRKVLDAESDREAVLASFVTGLDPDDERLLREVLGHARAAEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDD9</accession>
    <name>Q9RDD9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2552</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626790.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976252.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2552"/>
    <dbReference type="GeneID" id="1097986"/>
    <dbReference type="KEGG" id="sco:SCO2552"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2597"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDD9"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="PhylomeDB" id="Q9RDD9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB66230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="26130" checksum="1A5AD4B31E2520C1" modified="2000-05-01" version="1">MTAPVFVVDSLRPQDLPAGEYVLDGPEGRHAVSVKRLRAGEDVVLTDGRGHWAEGTVKAAEGKDRLVVTVPGGVREEPAEQPRITVVQALPKGDRGELAVETMTEVGVDAIVPWAASRCITQWKGERGLKALGKWRATAREAGKQSRRVRFPDVADAASSKQVASLLAAADFAAVLHESGDVPLSDAELPASGDIVLVVGPEGGVSPDELALFAEAGADPYRLGRSVLRTSTAGTAATAVLLARTGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ2</accession>
    <name>Q9RDJ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2733</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626965.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028549.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2733"/>
    <dbReference type="GeneID" id="1098167"/>
    <dbReference type="KEGG" id="sco:SCO2733"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2789"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_6_11"/>
    <dbReference type="InParanoid" id="Q9RDJ2"/>
    <dbReference type="OMA" id="WFMQNFS"/>
    <dbReference type="PhylomeDB" id="Q9RDJ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="279" mass="28965" checksum="A59B3DA1BC0AE95D" modified="2000-05-01" version="1">MTSPALTLVLGGTGKTGRRVVRRLTGRGHVVRIGSRTGGIPFDWNDSTTWQPALTGVDAVYVSYQPDLAVPGAPEAIGAFAELAVRTGARRLVLLSGRGEPEAEACEKALAASGAQWTVLRASFFAQNFSEGDFLGPVLEGELALPVGDVQEPFVDADDIAEVAATVLAEGGHTGRTYDLTGPRLLTFAQATAAIGAATGREIGYVTVPAEAYAAELAAHGVPDTVTDLLTYLFTSVLDGRNAYLGDGVRQVLGRPARDFTDHVAEAAATGVWTPGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJY7</accession>
    <name>Q9RJY7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1183</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625473.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977648.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1183"/>
    <dbReference type="DNASU" id="1096606"/>
    <dbReference type="GeneID" id="1096606"/>
    <dbReference type="KEGG" id="sco:SCO1183"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1182"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065561_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJY7"/>
    <dbReference type="OMA" id="RLLGYWD"/>
    <dbReference type="PhylomeDB" id="Q9RJY7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="100"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="389" mass="41517" checksum="035DDDD4BBA991E7" modified="2000-05-01" version="1">MTTTLSPDTARQIVPPEERYAAELAFLAAYDDGPRPPAWRLTPRAVVTFVMGSDGRALRLPEGAETPEGVPRRLTVEGKFVGDRSLVERCVVTLAGERGLLLVGEPGTAKSMLSELLSAAVCGTSGLVVQGTAGTTEDQLKYGWNYALLLAQGPSRTALVPSPVLTAMARGGIARVEEVTRCLPEVQDALVSLLSERRIAVPELSGTDDALAHAAPGFNLIATANLRDKGVSEMSAALKRRFNFETVGPIPDLDAETALVRSQARASVERAGAPFKVDEAVLEALVVAFRDLREGRSTEGWEVERPSTVMSTAEAVSVAGALGLAAAYFPGDRDVLGLLPGHLLGVVRKDDPADAARLRGYWDGPVRRRAEQGSATWRTLWDLRTVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL09</accession>
    <name>Q9RL09_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0309</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624636.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027006.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0309"/>
    <dbReference type="GeneID" id="1095733"/>
    <dbReference type="KEGG" id="sco:SCO0309"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.284"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030169_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RL09"/>
    <dbReference type="OMA" id="CCIASNA"/>
    <dbReference type="PhylomeDB" id="Q9RL09"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="362" mass="38846" checksum="8846C9977649BF8C" modified="2000-05-01" version="1">MPSRRVWRGRGGPGDLPASPPGALDGLGVTGSYGRTLTLDQLLAEAETDALLVLHRGRLVHEEYRHGYEAHVPHFNASAAKSYLGLLAATLAHEGHLDRGARVARYVPELSGTAFGDAQVDHLMHMGTRMSYAGRPYDKALEAQRYFAVLAPRLRPYGYSGPATIREHLATARATGEPGTEFRYENGNVEALAEVLRRITGLSTSALMSEMIWSRIGAEEDAYYLVDADGAEAACGGFSATARDVARLGELVRCGGAVGDRQVLPEAVTAPARSVPDGCPRRVRFPAAPADSPATLSYHDLWWILNDPYGSFMASGIHGQRLFVSPALDLVVVHYASQVVSPAVPQVPLVQAFLSIGAHLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL24</accession>
    <name>Q9RL24_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0293</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624621.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026995.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0293"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095717"/>
    <dbReference type="KEGG" id="sco:SCO0293"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.267"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RL24"/>
    <dbReference type="OMA" id="GPTINTQ"/>
    <dbReference type="PhylomeDB" id="Q9RL24"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="688"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="796" mass="83992" checksum="1DA7E12463E4A584" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Q9</accession>
    <name>Q9S1Q9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0232</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37147">
        <property type="entry name" value="T37147"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624564.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026944.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0232"/>
    <dbReference type="GeneID" id="1095656"/>
    <dbReference type="KEGG" id="sco:SCO0232"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.205"/>
    <dbReference type="HOGENOM" id="CLU_209263_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="61" mass="6190" checksum="B41F9C27F76AC62B" modified="2000-05-01" version="1">MRLRCSEGASWIVTPALTESVAASVRVGLPVPAGDLTPTEAVAARRAGADAVKLFPASIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1W6</accession>
    <name>Q9S1W6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37090">
        <property type="entry name" value="T37090"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624384.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978788.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095459"/>
    <dbReference type="KEGG" id="sco:SCO0026"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.23"/>
    <dbReference type="eggNOG" id="ENOG5031WH3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1561963_0_0_11"/>
    <dbReference type="OMA" id="EAYAPNE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176960" evidence="2">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18284" checksum="8A005823971A42CE" modified="2000-05-01" version="1">MRRLGLSAVMISILAVTGCGGSQDGDAAAAKPAKSKAASASPATQKSKAPERNLQQVERDLRFAVAPHKPQMQPLQSGSCIVHGVAPTRRVLSKAEFEAIVGRLQKRGWSPLGPLRYSDDETYGKMSYLRLQSGEWEISLGSAPMPSEMREAYAPNEGSIIAAISWKCTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Y4</accession>
    <name>Q9S1Y4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0010</name>
        <name evidence="4" type="ordered locus">SCO7837</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37072">
        <property type="entry name" value="T37072"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624371.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631865.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026773.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095439"/>
    <dbReference type="GeneID" id="1103275"/>
    <dbReference type="KEGG" id="sco:SCO0010"/>
    <dbReference type="KEGG" id="sco:SCO7837"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7944"/>
    <dbReference type="eggNOG" id="ENOG5033KHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821166_0_0_11"/>
    <dbReference type="OMA" id="SAWTHEG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC03655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="363" mass="40953" checksum="79901ED5A27431AD" modified="2000-05-01" version="1">MTGRTLRFLGYALATGCGSLLLKHFVIAPGPPVGHIPWVLRLLIMLGILEGGWLVFRASRRVVVRGRRHRVRVLTGFEELRGERYILYLRPFALDIRMSLPPPEAPGWWMRSPYELPGLTMEDFLVRQFTRHGRVVAVGEPGEELPLLGAQRGYLPLEGWERTVSELIQGAHSVLMSVAPGPGTVWEFTEALRTMPPERLVLMVCCGPEEYDAFRSAVVEKYAVRKSEEPGSTWAPLPRLPDCPARPPASKREWQSPLRAFVTFDQQWQPSLHWFVVTVPRIRHVWTMRRLVRERIDALVGAWAALPQRQASPGTIPPPAPVVTTPPPPPVLSPLPQQPLLGSTVVGLNVRPPERRTRRRGRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-09-18" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2H4</accession>
    <name>PTWC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PTS system N-acetylglucosamine-specific EIIC component</fullName>
            <shortName evidence="6">PTS system GlcNAc-specific EIIC component</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GlcNAc-specific transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">N-acetylglucosamine permease IIC component</fullName>
            <shortName evidence="6">GlcNAc permease IIC component</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nagE2</name>
        <name evidence="7" type="ordered locus">SCO2907</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="61" first="1237" last="1251">
            <title>The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development.</title>
            <authorList>
                <person name="Rigali S."/>
                <person name="Nothaft H."/>
                <person name="Noens E.E.E."/>
                <person name="Schlicht M."/>
                <person name="Colson S."/>
                <person name="Mueller M."/>
                <person name="Joris B."/>
                <person name="Koerten H.K."/>
                <person name="Hopwood D.A."/>
                <person name="Titgemeyer F."/>
                <person name="van Wezel G.P."/>
            </authorList>
            <dbReference type="PubMed" id="16925557"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05319.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2010" name="Mol. Microbiol." volume="75" first="1133" last="1144">
            <title>The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control.</title>
            <authorList>
                <person name="Nothaft H."/>
                <person name="Rigali S."/>
                <person name="Boomsma B."/>
                <person name="Swiatek M."/>
                <person name="McDowall K.J."/>
                <person name="van Wezel G.P."/>
                <person name="Titgemeyer F."/>
            </authorList>
            <dbReference type="PubMed" id="20487300"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.07020.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine (GlcNAc) transport (PubMed:16925557, PubMed:20487300). High-affinity permease, which exhibits a narrow specificity for GlcNAc (PubMed:20487300). Essential for C-signaling between vegetative growth and development (PubMed:20487300).</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">2.6 uM for GlcNAc</KM>
            <Vmax evidence="4">0.55 nmol/min/mg enzyme</Vmax>
        </kinetics>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3 4">Induced by GlcNAc (PubMed:20487300). Transcriptionally activated by AtrA (PubMed:20487300). Expression is repressed by DasR in the absence of glucosamine 6-P (GlcN6P) (PubMed:16925557).</text>
    </comment>
    <comment type="domain">
        <text evidence="2">The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3 4">Mutant is unable to grow on GlcNAc, while growth on glucose, fructose, xylose, mannose, sucrose or galactose is not impaired (PubMed:20487300). Mutant is insensitive to GlcNAc (PubMed:16925557, PubMed:20487300).</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36130">
        <property type="entry name" value="T36130"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627133.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028657.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2H4"/>
    <dbReference type="SMR" id="Q9S2H4"/>
    <dbReference type="STRING" id="100226.SCO2907"/>
    <dbReference type="TCDB" id="4.A.1.1.20">
        <property type="family name" value="the pts glucose-glucoside (glc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1098340"/>
    <dbReference type="KEGG" id="sco:SCO2907"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2966"/>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2H4"/>
    <dbReference type="OMA" id="ETDATIM"/>
    <dbReference type="PhylomeDB" id="Q9S2H4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090587">
        <property type="term" value="F:protein-phosphocysteine-glucosamine phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090563">
        <property type="term" value="F:protein-phosphocysteine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015764">
        <property type="term" value="P:N-acetylglucosamine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000447882" description="PTS system N-acetylglucosamine-specific EIIC component">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16925557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="20487300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="16925557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAB50988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="416" mass="44168" checksum="5A9240CDDDBD1572" modified="2000-05-01" version="1">MSTATDTAAPAKKRGSGLFQGLQKVGRSLQLPIAVLPAAGIMVRLGQDDIFGKDGLGWDKVAAVFNNAGGALTGSLPILFCIGVAIGFAKKADGSTALAAVVGFLVYSKVLEAFPVTEAVVQDGADVAATYNDPGVLGGIIMGLLAAVLWQRYHRKKLVDWLGFFNGRRLVPIIMAFVGIVVGVFFGLVWEPIGDGISNFGEWMTGLGSGGAALFGGVNRALIPVGMHQFVNTVAWFQLGDFTNSAGDVVHGDITRFLAGDPSAGIFQAGFFPIMMFGLPAAALAMAHTARPERRKAVLGMMISLAATSFVTGVTEPIEFSFMFIAPVLYVLHAVLTAISMAITWGLGVHAGFNFSAGFIDYALNWHLATKPWLIIPIGLVFAAIYYVTFRFAIVKFNLKTPGREPEEEVEDLTKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2H9</accession>
    <name>IXTPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2902</name>
        <name type="ORF">SCE19A.02c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36125">
        <property type="entry name" value="T36125"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627128.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028655.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2H9"/>
    <dbReference type="SMR" id="Q9S2H9"/>
    <dbReference type="STRING" id="100226.SCO2902"/>
    <dbReference type="GeneID" id="1098335"/>
    <dbReference type="KEGG" id="sco:SCO2902"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2961"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_1_11"/>
    <dbReference type="InParanoid" id="Q9S2H9"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="PhylomeDB" id="Q9S2H9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000178238" description="dITP/XTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <sequence length="200" mass="20890" checksum="AB1F41B4C448620C" modified="2000-05-01" version="1">MTRLILATRNAGKITELRAILADAGLPHDLVGADAYPHIPDVKETGVTFAENALLKAHALAEATGLPAVADDSGLCVDVLNGAPGIFSARWAGRHGDDQANLDLLLAQIADIADEHRGAHFACAAALALPDGTERVVEGQLKGTLRHAPAGTGGFGYDPILQPEGETRTCAELTAEEKNAISHRGKAFRALVPVVRELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Y0</accession>
    <name>Q9S2Y0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2071</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34941">
        <property type="entry name" value="T34941"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626330.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028126.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2071"/>
    <dbReference type="GeneID" id="1097505"/>
    <dbReference type="KEGG" id="sco:SCO2071"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2103"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_11"/>
    <dbReference type="InParanoid" id="Q9S2Y0"/>
    <dbReference type="OMA" id="ETVVMWW"/>
    <dbReference type="PhylomeDB" id="Q9S2Y0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="10"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB51980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="528" mass="57164" checksum="8E812F4040880AF1" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX04</accession>
    <name>Q9WX04_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3330</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36278">
        <property type="entry name" value="T36278"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627540.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028913.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3330"/>
    <dbReference type="GeneID" id="1098764"/>
    <dbReference type="KEGG" id="sco:SCO3330"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3390"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_11"/>
    <dbReference type="InParanoid" id="Q9WX04"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="PhylomeDB" id="Q9WX04"/>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="His_deacetylse_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB45364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="367" mass="38987" checksum="D855D339A177621F" modified="1999-11-01" version="1">MDPVRLALTRSLVGALGLDREVEVVAARPAGESTLRLVHREDYIDAVRAASADPRSADGSYGLGTVDDPAFAGMHEVSALIAGQSVGAAEAVWRGDALHAVNFAGGLHHAMPGAASGFCVYNDAALAIARLLELGAERVAYVDVDVHHGDGVQAAFWEDPRVLTVSLHEHPATLFPQTGWPEETGADCAEGSAVNVALPAGTGDAGWLRAFHAVVPEVLADFRPQVLVTQHGADTHFEDPLAHLAVSLDAQRAVQVACHELAHEYAGGRWVALGGGGYAVVEVVPRSWAHLVGVAAGRPVEPETVIPEGWRQEVYARTRQLGPMRMTDGRWPVSYASWEAGYDPADRLDQAVRAARRAVFPLRGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7T8</accession>
    <name>Q9X7T8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35347">
        <property type="entry name" value="T35347"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631317.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971883.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7261"/>
    <dbReference type="GeneID" id="1102699"/>
    <dbReference type="KEGG" id="sco:SCO7261"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7363"/>
    <dbReference type="eggNOG" id="ENOG5032UXB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124842_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X7T8"/>
    <dbReference type="OMA" id="RMYGLSW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="15561" checksum="F4A00BA7BF68FCB2" modified="1999-11-01" version="1">MANVSHSRGDITSHPDAPEMQARYARVLGGRDVALVDGPVFLLGLYCAVSPWILHFTTSQPSLVAHNLIVGVAIGLLALGFTRAPERMYGLSWAMCAIGVWMIISPWIVGSSPDAGVIWNNIVIGALALLLGMVCAGTAARSAPRRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7W2</accession>
    <name>ISPG1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) 1</fullName>
            <ecNumber evidence="1">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispG1</name>
        <name type="synonym">gcpE</name>
        <name type="synonym">ispG</name>
        <name type="ordered locus">SCO6767</name>
        <name type="ORF">SC6A5.16</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="ChemBioChem" volume="5" first="311" last="323">
            <title>A proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments.</title>
            <authorList>
                <person name="Brandt W."/>
                <person name="Dessoy M.A."/>
                <person name="Fulhorst M."/>
                <person name="Gao W."/>
                <person name="Zenk M.H."/>
                <person name="Wessjohann L.A."/>
            </authorList>
            <dbReference type="PubMed" id="14997523"/>
            <dbReference type="DOI" id="10.1002/cbic.200300743"/>
        </citation>
        <scope>3D-STRUCTURE MODELING OF 271-375</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35407">
        <property type="entry name" value="T35407"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630839.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031167.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X7W2"/>
    <dbReference type="SMR" id="Q9X7W2"/>
    <dbReference type="STRING" id="100226.SCO6767"/>
    <dbReference type="GeneID" id="1102206"/>
    <dbReference type="KEGG" id="sco:SCO6767"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6876"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7W2"/>
    <dbReference type="OMA" id="MRIAEQM"/>
    <dbReference type="PhylomeDB" id="Q9X7W2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000190635" description="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) 1">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <sequence length="384" mass="40594" checksum="62D8EA4CF30DBC32" modified="1999-11-01" version="1">MTAIPLGLPGVPVRPIAERRVSRRIQVGPVAVGGGAPVSVQSMTTTRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIAKAAKDHGTPIRIGVNAGSLDRRLLQKYGRATPEALAESALWEASLFEEHDFRDIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSTPPVEEIKVGIQILESLNLRQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGEVVKTVPESKIVETLIEEAMRIAEQMEKDGASGAPAVTVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X853</accession>
    <name>NUOD1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit D 1</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit D 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit D 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoD1</name>
        <name type="ordered locus">SCO3392</name>
        <name type="ORF">SCE126.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36080">
        <property type="entry name" value="T36080"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627599.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975441.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X853"/>
    <dbReference type="SMR" id="Q9X853"/>
    <dbReference type="STRING" id="100226.SCO3392"/>
    <dbReference type="GeneID" id="1098829"/>
    <dbReference type="KEGG" id="sco:SCO3392"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3455"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_11"/>
    <dbReference type="InParanoid" id="Q9X853"/>
    <dbReference type="OMA" id="GGRMHYM"/>
    <dbReference type="PhylomeDB" id="Q9X853"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000357939" description="NADH-quinone oxidoreductase subunit D 1">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <sequence length="383" mass="42128" checksum="99DF5A7C0C32867A" modified="1999-11-01" version="1">MTPTTETTVGIGGAAESTDMVLNIGPQHPSTHGVLRLKLVLDGERITSAEPVIGYMHRGAEKLFEARDYRQIIMLANRHDWLSAFSNELGVVLAVERMLGMEVPTRAVWTRTLLAELNRVLNHLMFLGSYPLELGGITPVFYAFREREVLQNVMEEVSGGRMHYMFNRVGGLKEDLPAGWTTRARGAVAAVRSRMDVFDDLVLGNEIFRGRTRGVGALSAEAVHAYGVSGPVARASGVDFDLRRDEPYLAYGELQDTLKVVTRTDGDCLARFECLLAQTHNALDLADACLDRLAELAPGPVNQRLPKVLKAPEGHTYAWTENPLGINGYYLVSKGEKTPYRLKLRSASYNNIQALAELLPGTLVADMVAILGSLFFVVGDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X886</accession>
    <name>Q9X886_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3294</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36114">
        <property type="entry name" value="T36114"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627505.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028890.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3294"/>
    <dbReference type="GeneID" id="1098728"/>
    <dbReference type="KEGG" id="sco:SCO3294"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3355"/>
    <dbReference type="eggNOG" id="ENOG5033KHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651987_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="48960" checksum="8B2DA96F2FA45A3B" modified="1999-11-01" version="1">MSRPQPGQSPDRLPEKPLPRWFPAALPVSVLVAVLWGPVYAAVLCGVAAVAVAYATTRKPELWHLAAGTGLCAAGVLAQAFAYYLILRDGSLGPHGSAAVLFLLGLQFFLHGRKVRRAAQLTLSALRRHREENGLLRAAEPLGERRPGARRVPFAMTSVFGAVVSGLGSLFLCFTLLALRDLLTTGGNPWWASLVVAALCAQAVLFIGLGNTILRTGVQYYDTVVSSPDDLAGRQYVLYLRSFRDDHRLSRPHRIPLAGAWLAAAVSLGQGEEERIADALSWAGPLVGVGAPGERVPRAGARRMYLPPDDWQRPVSTMMRGAALVVIVLGKGPGTLWEIREAMRILPPERLLLLVPMKEKAYDEFRELAGDLAPGVLPAYRRSRALSSRVRGIIHFEPDWTARFVALRRPPPLEDPLVGSLDRAMWPAMVRLTELELERRADGRRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA11</accession>
    <name>Q9XA11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36722">
        <property type="entry name" value="T36722"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628041.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029272.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3853"/>
    <dbReference type="GeneID" id="1099289"/>
    <dbReference type="KEGG" id="sco:SCO3853"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3924"/>
    <dbReference type="eggNOG" id="COG3879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040273_2_0_11"/>
    <dbReference type="InParanoid" id="Q9XA11"/>
    <dbReference type="OMA" id="IKVMDQR"/>
    <dbReference type="PhylomeDB" id="Q9XA11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="25761" checksum="3013049C648BF4BD" modified="1999-11-01" version="1">MRVLTAAVFALAGLIFFTSFDTAKGTNIRTDSSLLKLSDLIHERSRENGVLEESNGALREDVESLAERDDGRTKSEDDKLAALEEKAGTQKLTGEAITVTLDDAPPDATAKLPGYPEPQPDYLVIHQQDLQAVVNALWQGGAEGIKVMDQRLISTSAVRCVGNTLILQGRVYSPPYKIQAVGDPERLKKALAKSPAIQNYMVYVNVYGLGWKVEDDGRATLPGYSGTADLHYAQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA20</accession>
    <name>Q9XA20_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3844</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36713">
        <property type="entry name" value="T36713"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628032.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975090.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3844"/>
    <dbReference type="GeneID" id="1099280"/>
    <dbReference type="KEGG" id="sco:SCO3844"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3914"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131367_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA20"/>
    <dbReference type="OMA" id="GQWIVED"/>
    <dbReference type="PhylomeDB" id="Q9XA20"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="18670" checksum="65FD377211ECB097" modified="1999-11-01" version="1">MSELTLTVMRLGFLAVLWLFVIVAVQVIRSDLFGTRVTQRGARRDAARPQQTATRQGQAPPPQRQQSGGGRGRRGAPTKLVVTEGTLTGTTVALQGQTITLGRAHDSTIVLDDDYASSRHARIYPDQNGQWIVEDLGSTNGTYLDRARLTTPTPIGPGAPIRIGKTVIELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA35</accession>
    <name>Q9XA35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3578</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36563">
        <property type="entry name" value="T36563"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029096.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3578"/>
    <dbReference type="GeneID" id="1099014"/>
    <dbReference type="KEGG" id="sco:SCO3578"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3634"/>
    <dbReference type="eggNOG" id="COG0003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044079_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA35"/>
    <dbReference type="OMA" id="DAMMLDM"/>
    <dbReference type="PhylomeDB" id="Q9XA35"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="481" mass="50941" checksum="306DE8625ECF6FC5" modified="1999-11-01" version="1">MSPDDPARHQKGSPAGHQKGDRARHQEGARRLTPARVLDVDALLEDPHNRIVVCCGSGGVGKTTTAAALGLRAAERGRKVVVLTIDPARRLAQSMGIDSLDNTPRRVKGVDDSAGGELHAMMLDMKRTFDEIVESHADPERAAAILGNPFYQSLSAGFAGTQEYMAMEKLGQLRSRDEWDLIVVDTPPSRSALDFLDAPKRLGSFLDGKLIRVLLAPAKVGGRAGMKFLNVGMSMMTGVLGKVLGGQFLKDVQTFVAAMDSMFGGFRTRADATYKLLQAPGTAFLVVAAPERDALREAAYFVQRLAAEDMPLAGLVLNRVHGSGADRLSAERALAAAENLEDPRIVDQDGGKAGLRTSSGNSPDTYGSSGPADSEPGDSAPDTSPGASAASPEASDTSPEVSDTAERSVDALAAGLLRLHAERMHLLAREQRTRDRFTARHPEVAVTEVAALPGDVHDLAGLRDIGARLATGRPELPEPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA63</accession>
    <name>Q9XA63_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3814</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36495">
        <property type="entry name" value="T36495"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628003.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029245.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3814"/>
    <dbReference type="GeneID" id="1099250"/>
    <dbReference type="KEGG" id="sco:SCO3814"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3882"/>
    <dbReference type="eggNOG" id="COG3617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993657_0_0_11"/>
    <dbReference type="OMA" id="VHRVNEC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01040">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51750">
        <property type="entry name" value="BRO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="35795" checksum="816EE533FFADA12C" modified="1999-11-01" version="1">MNEPSERKNFAKQNDAIDVSDFVYAATGARVRRLTMPGGSHWFPAADVCKELGYTTTRKALLDHVPEEHRDSLETVTGSHSLSIPAGRKWRRDLQLIDLQGLILLVNACTKPACAPFKQWVAEVVETVQREGSYSLDEAEVQPTEPGAPVAYAMPDQVADAIVRLEAHNLKLDEELAEGQRTSIALQREMLATQQATLAVQQSTLAVQQAMVHALERIAGRFDTLVLHQGSPRGHLAPVPTTESVLADWRQRLSVTEDVWTVARAIAPVLVEKGELREPLESIAGRTGLSVRRVNECLRLLRTHACIRSRGGAEDGAPVYVLHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAK5</accession>
    <name>Q9XAK5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35365">
        <property type="entry name" value="T35365"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627792.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029112.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3597"/>
    <dbReference type="GeneID" id="1099033"/>
    <dbReference type="KEGG" id="sco:SCO3597"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3654"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_3_0_11"/>
    <dbReference type="InParanoid" id="Q9XAK5"/>
    <dbReference type="OMA" id="NPCSGYL"/>
    <dbReference type="PhylomeDB" id="Q9XAK5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042779">
        <property type="term" value="P:tRNA 3'-trailer cleavage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="270" mass="27866" checksum="C2D1CE09B55D90C6" modified="1999-11-01" version="1">MKGDLRFTVLGSASPYPRAGNPCSGYLVEGGGGGGGGGGEGGGGVTRLWMDAGSGTLGALREHIRLDQLDGIWISHLHADHCADLLTAYYGLLYAEVELAAPVPLLAPPGIADRLADFLTNGPARSPVEDAFRVVELHDRHRARIGGLTLTSRAVSHGMPAFGVRVETEDGARLAYSGDSAPCEALTQLADDCTVLLCEADSAQAPPAGTEAVHHTPEEAGTTAATAGAHRLVVTHLGPFLEPSAALDRAAARYQGPVEYAAPGRTFVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAM1</accession>
    <name>Q9XAM1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6709</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35027">
        <property type="entry name" value="T35027"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630782.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972287.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6709"/>
    <dbReference type="GeneID" id="1102148"/>
    <dbReference type="KEGG" id="sco:SCO6709"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6816"/>
    <dbReference type="eggNOG" id="COG3285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAM1"/>
    <dbReference type="OMA" id="TTAWWKE"/>
    <dbReference type="PhylomeDB" id="Q9XAM1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="38531" checksum="FDCD0127B1AB662E" modified="1999-11-01" version="1">MAEAVELEAGGRSVRLSSPGKVFFPEHGYTKLDVARYYQAVAPGVLRALRERPTTLQRYPDGITGEWFYQKRAPKGMPDWIPTAHITFPSGRSADEMCPTEEAAVLWAAQYGTLTFHPWPVRRDDVDHPDELRIDLDPQPGTDYDDAARAAHELRAVLEEFGGLRGWPKTSGGRGIHVFVPIEPRWTFTQVRRAAIAVGREMERRMPERVTIKWWKEERGERIFIDYNQTARDRTIASAYSVRPRPNAPVSAPLTWDEVGVAHPRDFDITTMPARFAELGDVHAGMDDTRYSLDALLELATKDEHDHGLGDLPYPPEYPKMPGEPSRVQPSRARKKAPGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAM3</accession>
    <name>Q9XAM3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6707</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35025">
        <property type="entry name" value="T35025"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630780.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031122.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6707"/>
    <dbReference type="DNASU" id="1102146"/>
    <dbReference type="GeneID" id="1102146"/>
    <dbReference type="KEGG" id="sco:SCO6707"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6814"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_4_1_11"/>
    <dbReference type="InParanoid" id="Q9XAM3"/>
    <dbReference type="OMA" id="AGFRWHK"/>
    <dbReference type="PhylomeDB" id="Q9XAM3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006266">
        <property type="term" value="P:DNA ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_ligase_A_C" evidence="4">
        <location>
            <begin position="215"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="39874" checksum="7A995A55116077B1" modified="1999-11-01" version="1">MDLPVMPPVKPMLAKSVAKIPPGMHYEAKWDGFRAIVYRDGDEVELGSRTGKPLTRYFPELVVAVRERLPERCVVDGEIVIARDGHLDFDALTERIHPADSRVRTLAERTPASLVAFDLLALDDASLLDVGLADRRALLVRALSGVTPPVHVAPATDDIEVARRWFEQYEGAGLDGVVAKPLDLRYRQDERAMYKIKHERTADVVVAGYRFHKSGPVVGSLLLGLYDDRGLLQHVGVSAAFTMKRRAELVAELEPLRMDDARGHPWAAWAEEAAHESARLPGAPSRWSGKKDLSWVPLRPERVVEVAYDHMENGARFRHTARFRRWRPDRTPESCTYAQLEEPVRYDLAEILGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4X7</accession>
    <name>Q9Z4X7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 4-hydroxyphenylpyruvic acid dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2013" name="Angew. Chem. Int. Ed." volume="52" first="9677" last="9681">
            <title>Inversion of enantioselectivity of a mononuclear non-heme iron(II)-dependent hydroxylase by tuning the interplay of metal-center geometry and protein structure.</title>
            <authorList>
                <person name="Pratter S.M."/>
                <person name="Konstantinovics C."/>
                <person name="Di Giuro C.M."/>
                <person name="Leitner E."/>
                <person name="Kumar D."/>
                <person name="de Visser S.P."/>
                <person name="Grogan G."/>
                <person name="Straganz G.D."/>
            </authorList>
            <dbReference type="PubMed" id="23881738"/>
            <dbReference type="DOI" id="10.1002/ANGE.201304633"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36247">
        <property type="entry name" value="T36247"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627442.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028841.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="PDB" id="3ZGJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=1-371"/>
    </dbReference>
    <dbReference type="PDBsum" id="3ZGJ"/>
    <dbReference type="SMR" id="Q9Z4X7"/>
    <dbReference type="STRING" id="100226.SCO3229"/>
    <dbReference type="GeneID" id="1098663"/>
    <dbReference type="KEGG" id="sco:SCO3229"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3292"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_1_1_11"/>
    <dbReference type="InParanoid" id="Q9Z4X7"/>
    <dbReference type="OMA" id="LYTPNIM"/>
    <dbReference type="PhylomeDB" id="Q9Z4X7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="178"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mandelate</name>
            <dbReference type="ChEBI" id="CHEBI:17656"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mandelate</name>
            <dbReference type="ChEBI" id="CHEBI:17656"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="99"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB38519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="3ZGJ"/>
        </source>
    </evidence>
    <sequence length="371" mass="40198" checksum="E3CA2C2C05E91753" modified="1999-05-01" version="1">MLPPFPFLHWRAAMPPSDIAYAELYVADDREASGFLVDSLGFVPLAVAGPATGTHDRRSTVLRSGEVTLVVTQALAPDTPVARYVERHGDSIADLAFGCDDVRSCFDRAVLAGAEALQAPTPSHRAGQDAWFATVSGFGDIRHTLVPAADGDGAGLLPPDRDWALLPAATGRTGPRPLLDHVAVCLESGTLRSTAEFYEAAFDMPYYSSEYIEVGEQAMDSIVVRNAGGGITFTLIEPDDTRVPGQIDQFLSAHDGPGVQHLAFLVDDIVGSVRSLGDRGVAFLRTPGAYYDLLTERVGAMADAIEDLRETNVLADRDEWGYLLQIFTRSPYPRGTLFYEYIQRNGARGFGSSNIKALYEAVEREREVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y1</accession>
    <name>Q9Z4Y1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3250</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36198">
        <property type="entry name" value="T36198"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627462.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028858.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3250"/>
    <dbReference type="GeneID" id="1098684"/>
    <dbReference type="KEGG" id="sco:SCO3250"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3314"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_1_11"/>
    <dbReference type="InParanoid" id="Q9Z4Y1"/>
    <dbReference type="OMA" id="NGWEYRI"/>
    <dbReference type="PhylomeDB" id="Q9Z4Y1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="67"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB38894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="384" mass="44029" checksum="2A4C13625B1A3F17" modified="1999-05-01" version="1">MAGPRKRNPNGAGTITKRKDGRYQCAVYVLQPDGTRARKFAYGKTWAECDVKRRELLAKVDQGVPVPTKSAKLSEWMPYWLDNVIKPRRKLSTYDKYEAHVRLYLVPLLGAKRLESLGVADVRRFLVRLEKETTAATAKESHRVLRSALTSACREELITRNVAKLVEPPRTDSRELKPWTLDETLDFLAASRKDPLYAAFVLAIAMGLRRGEIIGLRWSDLDLDNRVLYVRQQTQRRRGVLYDDDPKSRRRRAVPLPALCIAPLRWHRMRQAAARIKAGEQWQESGYVFTTRTGRQVEPRNVYRSFTRVAESAGLRVIRLHDARHGTATLLTAAGVAPRVVMEILGHSQISITMDVYTHVVQDTQREAMSHMDRLLRKRRPDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z549</accession>
    <name>Q9Z549_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative quinone binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35906">
        <property type="entry name" value="T35906"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630229.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030668.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101564"/>
    <dbReference type="KEGG" id="sco:SCO6123"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6226"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_3_11"/>
    <dbReference type="InParanoid" id="Q9Z549"/>
    <dbReference type="OMA" id="WDAFWGQ"/>
    <dbReference type="PhylomeDB" id="Q9Z549"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="13800" checksum="1FC4F5F371F68168" modified="1999-05-01" version="1">MTPQFNAISLIVSDMAASVAFYRRLGFAFPEGSEGQPHAEAALPGGIRLLLDTEESIRSFTPGWEPPAGGGRHSLALLCDTPAEVDAFYAELTGAGCKGEREPWDAPWGQRYAVLGDPDGHGVDLFAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z587</accession>
    <name>Q9Z587_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5492</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB37568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35808">
        <property type="entry name" value="T35808"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973506.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5492"/>
    <dbReference type="GeneID" id="1100932"/>
    <dbReference type="KEGG" id="sco:SCO5492"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5576"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="InParanoid" id="Q9Z587"/>
    <dbReference type="OMA" id="SHVDEWR"/>
    <dbReference type="PhylomeDB" id="Q9Z587"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB37568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="232" mass="24455" checksum="9387C218509C9328" modified="1999-05-01" version="1">MAGMATHVITGAGSGIGAAVARRLHERGDEVVLHARDAGRAKELAAALPGAKTLVGDLSDPGKLSWALSHQSLPDRVDSLLHIAGVVDLGPVGDLTPKTWLHQLSVNLVAPAELTRLLLPQLRVAQGQVIFVNSGSGLNAHAGWAAYGASKHGLKALADALRQEEHANGVRVTSVYPGRTASPMQAKVHQQEGKDYDPAKWIDPESVATTILMALDLPRDAEVNDLTVRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBH6</accession>
    <name>Q9ZBH6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6437</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35924">
        <property type="entry name" value="T35924"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630522.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030918.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6437"/>
    <dbReference type="GeneID" id="1101876"/>
    <dbReference type="KEGG" id="sco:SCO6437"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6537"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_6_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBH6"/>
    <dbReference type="OMA" id="YAADVCR"/>
    <dbReference type="PhylomeDB" id="Q9ZBH6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="118"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="424" mass="44744" checksum="0480ABC85718ABDE" modified="1999-05-01" version="1">MHIAFVDSNPAALEAIRLAKEAGHRVTYLQSADPFYPPTERNLRIVGSVDHLVDNLVTTDAETVTRVLAARHAADPIDVVTAQLELSAEAVAVACRELGLRGTATDGVLTARRKDRCRAALDEAGLASARHALAETEEAALAAAEEIGYPVILKPPSGADSLLSYVATNPEEAAAGCRGVLTGLDAVPVQWHEQFTRGILVEEYLVGTLVSVELGAKDGEFFPFAVSGRFRWAEDEVVELGSYIPAALSEEQTGACVAYAADVCRAIGLDLGVFHLEIMVTERGPVLVEVNPRVMGGALPTIYRHATGADIFSGLLAILEPGAEVALPGTLDGCVGGRKVMARDGGTLAPGASLDRIADLPGVLEVVGFDSYGTGPGRTVNAGQIVARFMLRGPDHPSVVRTAEQILRRLEEDLGIALMIGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN5</accession>
    <name>Q9ZBN5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35481">
        <property type="entry name" value="T35481"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630278.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030710.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6174"/>
    <dbReference type="GeneID" id="1101615"/>
    <dbReference type="KEGG" id="sco:SCO6174"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6284"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041115_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBN5"/>
    <dbReference type="OMA" id="HTPIHHD"/>
    <dbReference type="PhylomeDB" id="Q9ZBN5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="206"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="395" mass="40658" checksum="E65AF45FA936EEAE" modified="1999-05-01" version="1">MLDIAEELHRWVEQGRDFAVATVVAVGGSAPRPTGAALAVDAGGTVVGSVSGGCVEGAVYELCRQALQDGETVLERFGYSDEDAFAVGLTCGGVIDVLVTPVRAADPVRPALAAALAAAARGETAAVARVVSGPAQLLGRALVVRADGSRTGGFGGHPELDRTAAAEAGAFLDAGRTGTLETGERGSRCGALLTLLIESSVPAPRMIVFGAIDFASALARAGKFLGHHVTVCDARPVFATPARFPDADEVVVEWPHEYLARTAVDARTVLCVLTHDAKFDIPLLRLALRLPVAYVGAMGSRRTHLDRAARLREAGVSDLELSRLRSPIGLDLGARTPEETALSIAAEIVAVRRGGTGTSLTGAHTPIHHDGPPAGWSLAHPRGGAGPLVGRTGPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O50487</accession>
    <name>RECA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">SCO5769</name>
        <name type="ORF">SC4H8.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35139">
        <property type="entry name" value="T35139"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629894.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030442.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50487"/>
    <dbReference type="SMR" id="O50487"/>
    <dbReference type="STRING" id="100226.SCO5769"/>
    <dbReference type="GeneID" id="1101211"/>
    <dbReference type="KEGG" id="sco:SCO5769"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5858"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_11"/>
    <dbReference type="InParanoid" id="O50487"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="PhylomeDB" id="O50487"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000122853" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="374" mass="39582" checksum="53FB852B15CA5AC8" modified="1998-06-01" version="1">MAGTDREKALDAALAQIERQFGKGAVMRMGDRTNEPIEVIPTGSTALDVALGVGGIPRGRVVEVYGPESSGKTTLTLHAVANAQKAGGQVAFVDAEHALDPEYAKKLGVDIDNLILSQPDNGEQALEIVDMLVRSGALDLIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKITSALNQSKTTAIFINQLREKIGVMFGSPETTTGGRALKFYASVRLDIRRIETLKDGTDAVGNRTRVKVVKNKVAPPFKQAEFDILYGQGISREGGLIDMGVENGFVRKAGAWYTYEGDQLGQGKENARNFLKDNPDLANEIEKKIKQKLGVGVHPEESATEPGADAASAAPADAAPAVPAPTTAKATKSKATAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>O69822</accession>
    <name>O69822_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO6428</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class A bacterial acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28698">
        <property type="entry name" value="T28698"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630514.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030909.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="O69822"/>
    <dbReference type="STRING" id="100226.SCO6428"/>
    <dbReference type="CAZy" id="CBM6">
        <property type="family name" value="Carbohydrate-Binding Module Family 6"/>
    </dbReference>
    <dbReference type="CAZy" id="GH92">
        <property type="family name" value="Glycoside Hydrolase Family 92"/>
    </dbReference>
    <dbReference type="GeneID" id="1101867"/>
    <dbReference type="KEGG" id="sco:SCO6428"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6528"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231981_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03397">
        <property type="entry name" value="PAP2_acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001011">
        <property type="entry name" value="Acid_Pase_classA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018296">
        <property type="entry name" value="Acid_Pase_classA_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01157">
        <property type="entry name" value="ACID_PHOSPH_CL_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174848" description="Acid phosphatase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1596"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="1689"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="797"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1600"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1674"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1761"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2269"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1761"/>
            <end position="1792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAA18915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="2314" mass="242149" checksum="DF4F9B3735FE39D7" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O70006</accession>
    <name>O70006_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5830</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35204">
        <property type="entry name" value="T35204"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629953.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030485.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5830"/>
    <dbReference type="GeneID" id="1101272"/>
    <dbReference type="KEGG" id="sco:SCO5830"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5927"/>
    <dbReference type="eggNOG" id="COG4759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050357_1_0_11"/>
    <dbReference type="InParanoid" id="O70006"/>
    <dbReference type="OMA" id="RDRCCAL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010350">
        <property type="entry name" value="Aim32/Apd1-like_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035042">
        <property type="entry name" value="UCP035042_thirdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA18528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="32980" checksum="3373A25A7562B920" modified="1998-08-01" version="1">MSTCSTVSRDLDEPVSGTAPVARTWLLLEQPGPWGAKALTSSHLDPALGRALDAAAKGTGVRVALVRRPGRHADRGTTAARRVYAAHTVPGNVWLHGATLKDPRRLLGLDFAALGRGDHRAFDSVLDGRAHAGDPLALVCTNGKRDRCCALLGRPLAAELAASGAHGVWEVTHLGGHRFSPTVLVLPHGYVYGRVQAHTVKGILHGAREDRIVIEGCRGNSAWDRPGQAAELALRSALGEDAAQALTVVRTDGAAPRWEVTLAHRDGRYWRVTVVQGASVPPRPESCTASVLGSPARMEATAVRALPVAAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O86721</accession>
    <name>O86721_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6539</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35231">
        <property type="entry name" value="T35231"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630620.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030996.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6539"/>
    <dbReference type="DNASU" id="1101978"/>
    <dbReference type="GeneID" id="1101978"/>
    <dbReference type="KEGG" id="sco:SCO6539"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6642"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083309_0_0_11"/>
    <dbReference type="InParanoid" id="O86721"/>
    <dbReference type="OMA" id="VDRHWNL"/>
    <dbReference type="PhylomeDB" id="O86721"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="30305" checksum="A790B7BC5122A016" modified="1998-11-01" version="1">MTALVSGTSPATDRGVGPMLRAWRERRRVSQLELALRADSSARHISFVETGRSRPSEEMVLRLAEHLDVPVRERNALLLAAGYAPHYPETPLDDPALGALREGMERLIRGYEPYPALVVDATYRVLAANRGIAMLMDGVAEHLLTPPLNAIRLTLHPDGLAPRIRNLREWRGHLLEQMERQIALHRSRPLRELYDEVAAYPVPESVPGAEPDEPVPYFALPMQIEHEGHVLSFISSISTFNTPMDVTVAELAIETLLPADPATVKYLQTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O86752</accession>
    <name>O86752_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5647</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35451">
        <property type="entry name" value="T35451"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629777.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030361.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5647"/>
    <dbReference type="GeneID" id="1101086"/>
    <dbReference type="KEGG" id="sco:SCO5647"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5730"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_5_2_11"/>
    <dbReference type="InParanoid" id="O86752"/>
    <dbReference type="OMA" id="PLYLFQL"/>
    <dbReference type="PhylomeDB" id="O86752"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="348"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="553" mass="59086" checksum="CAE1B32EE20787A3" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O86805</accession>
    <name>O86805_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4766</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35595">
        <property type="entry name" value="T35595"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628924.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029852.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4766"/>
    <dbReference type="GeneID" id="1100207"/>
    <dbReference type="KEGG" id="sco:SCO4766"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4838"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="InParanoid" id="O86805"/>
    <dbReference type="OMA" id="FATDDYP"/>
    <dbReference type="PhylomeDB" id="O86805"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="306" mass="32042" checksum="1D962F02C629ACF3" modified="1998-11-01" version="1">MIEARHLRVLRAVASTGSFSAAGRELGCTQPAVSQQMKALESSVGTPLLVRTGREMRLTQAGEALVRHAAGIIAGLTAAEEEVAAIAGLRAGRVRLVSFPSGSSTLVPTALAALRAAHPGTRVFLEESEPPKSVELLREGDCDVALAFRYEGAAGAEEWDDLVVRPLLTDRLVALVPEGHRLARSEGVGSVAIGELARESWIAGCPRCRGQLVEVCEGAGFTPRIDFATDDYPAVVGLVGAGLGVAVLPQLAVDSVRPRGVRTVTLEPAVRREIVALTLPDLAQVPAVTATLDELARAGARQSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O86813</accession>
    <name>O86813_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">SCO5753</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA19854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35686">
        <property type="entry name" value="T35686"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973271.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5753"/>
    <dbReference type="GeneID" id="1101195"/>
    <dbReference type="KEGG" id="sco:SCO5753"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5842"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_0_11"/>
    <dbReference type="InParanoid" id="O86813"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="PhylomeDB" id="O86813"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAA19854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="27302" checksum="E8F336C4A96C327E" modified="1998-11-01" version="1">MTGVPASAAGGSSSARRTGPRGASGAAQEPAGRTTSGGAVERDAGERRGATEGGAGARGGKIAAAAVNQASVWNVANLLTMLRLLLVPAFVALMLGNGGYDPAWRSFAWAAFAIAMITDLFDGHLARTYNLVTDFGKIADPIADKAIMGAALICLSALGDLPWWVTAVILGRELGITVLRFVVIRYGVIPASRGGKLKTLIQGIAVGMYVLALTGPLATLRFWVMAAAVVLTVATGLDYVKQAIVLRRRGIAERRAALKETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O86839</accession>
    <name>O86839_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35842">
        <property type="entry name" value="T35842"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629867.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973285.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5742"/>
    <dbReference type="GeneID" id="1101181"/>
    <dbReference type="KEGG" id="sco:SCO5742"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5830"/>
    <dbReference type="eggNOG" id="ENOG50347AB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194655_0_0_11"/>
    <dbReference type="OMA" id="FRSNVAP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8555" checksum="268CB8C019F6B2B8" modified="1998-11-01" version="1">MIRRREPVPFAFVAEADRFRSNVTPPPRERASFGQLAGRWLLGMTVVAGLVGSLVIGMPALSADQPSPHKQPSQASEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O87848</accession>
    <name>O87848_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6593</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35781">
        <property type="entry name" value="T35781"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630672.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031029.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6593"/>
    <dbReference type="GeneID" id="1102032"/>
    <dbReference type="KEGG" id="sco:SCO6593"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6700"/>
    <dbReference type="HOGENOM" id="CLU_008412_0_0_11"/>
    <dbReference type="OMA" id="DHATHIS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005506">
        <property type="entry name" value="DUF312"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03752">
        <property type="entry name" value="ALF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1147" mass="119042" checksum="E201811347BFDD65" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>P41108</accession>
    <accession>Q9L0L1</accession>
    <name>Y4650_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative lipoprotein SCO4650</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4650</name>
        <name type="ORF">SCD82.21</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Mol. Microbiol." volume="12" first="375" last="385">
            <title>Synthesis of ribosomal proteins during growth of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Blanco G."/>
                <person name="Rodicio R."/>
                <person name="Puglia A.M."/>
                <person name="Mendez C."/>
                <person name="Thompson C.J."/>
                <person name="Salas J.A."/>
            </authorList>
            <dbReference type="PubMed" id="7545948"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1994.tb01027.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-285</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L24552">
        <property type="protein sequence ID" value="AAC36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S49534">
        <property type="entry name" value="S49534"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628811.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974313.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P41108"/>
    <dbReference type="SMR" id="P41108"/>
    <dbReference type="STRING" id="100226.SCO4650"/>
    <dbReference type="GeneID" id="1100091"/>
    <dbReference type="KEGG" id="sco:SCO4650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4721"/>
    <dbReference type="eggNOG" id="ENOG50333DA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076599_0_0_11"/>
    <dbReference type="OMA" id="VDIWVDD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018233" description="Putative lipoprotein SCO4650">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="285" mass="29906" checksum="9E481A98E1EA2C10" modified="2001-10-18" version="2" precursor="true">MTGTTARRTVVSVAVSAALACVTACTGPGGSDDAGHSTGPTGSARPSASAPASSRAPALTGPSADALRKVERATGRAGSARVESTTVMGRELSLEAAGALGWDDGLTGTLTITYTGGTTAETMRRLGTTAMEARYLPDAYYARMGDEFAERVGGRHWIKYVYEDLEDLGGGAGAGFADQMRNTTPNQAVKLLLSAQDVRRVGEETTRGRRTTHWSGTMGGATAQSVDIWVDDRDLLVKKVERGRTETGELTQTAYYSDYGVRVLAERPPAADTADFKELLASQGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>P60515</accession>
    <accession>O54209</accession>
    <name>IF1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">SCO4725</name>
        <name type="ORF">SC6G4.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Loriaux A."/>
                <person name="Brans A."/>
                <person name="Dusart J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-65</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83011">
        <property type="protein sequence ID" value="CAA58140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35554">
        <property type="entry name" value="T35554"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628883.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948620.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P60515"/>
    <dbReference type="SMR" id="P60515"/>
    <dbReference type="STRING" id="100226.SCO4725"/>
    <dbReference type="GeneID" id="1100166"/>
    <dbReference type="GeneID" id="58470379"/>
    <dbReference type="GeneID" id="67399256"/>
    <dbReference type="KEGG" id="sco:SCO4725"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4796"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_11"/>
    <dbReference type="InParanoid" id="P60515"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="PhylomeDB" id="P60515"/>
    <dbReference type="PRO" id="PR:P60515"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000095877" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="73" mass="8411" checksum="C17FB7C2DD0D7912" modified="2004-03-01" version="1">MAKKQGAIEIEGTVVESLPNAMFKVELQNGHQVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q53876</accession>
    <name>GLMM_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="1">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmM</name>
        <name type="ordered locus">SCO4736</name>
        <name type="ORF">SC6G4.14</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35565">
        <property type="entry name" value="T35565"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628894.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974237.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q53876"/>
    <dbReference type="SMR" id="Q53876"/>
    <dbReference type="STRING" id="100226.SCO4736"/>
    <dbReference type="GeneID" id="1100177"/>
    <dbReference type="KEGG" id="sco:SCO4736"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4807"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_11"/>
    <dbReference type="InParanoid" id="Q53876"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="PhylomeDB" id="Q53876"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000147983" description="Phosphoglucosamine mutase">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <sequence length="452" mass="46896" checksum="1C341741D668E80D" modified="1999-05-01" version="2">MGRLFGTDGVRGVANADLTAELALGLSVAAAHVLAEAGTFAGHRATAVVGRDPRASGEFLEAAVVAGLASAGVDVLRVGVLPTPAVAHLTGALGADLGVMLSASHNAMPDNGIKFFARGGHKLADELEDRIESVYADHRTGAPWDRPTGSGVGRVRDYDEGLDQYVAHLVGVLPNRLDGLKIVLDEAHGAASRVSPEAFARAGAELVTIGAVPDGLNINDGCGSTHLDLLKAAVVEHGADLGIAHDGDADRCLAVDHTGAEVDGDQILAVLALAMREREALRSDTVVATVMSNLGFKLAMEREGIRFVQTGVGDRYVLEEMKEHGYALGGEQSGHVIILDHATTGDGTLTGLMLAARVAQTGRTLRDLASVMERLPQVLVNVPDVDKSRVTSSAELATAVAEAERELGSTGRVLLRPSGTEPLVRVMVEAADIEQARSVAGRLADSVKSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJN4</accession>
    <name>Q8CJN4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6325</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAD55511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34639">
        <property type="entry name" value="T34639"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733697.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6325"/>
    <dbReference type="GeneID" id="1101766"/>
    <dbReference type="KEGG" id="sco:SCO6325"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6438"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_4_0_11"/>
    <dbReference type="OMA" id="WWALAHA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="131"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="302" mass="30993" checksum="0BE2A3E7294A24EA" modified="2003-03-01" version="1">MVGPRDDEPRASGGRGGHSAARAHVTLLLLLGTVLAPLVAAGLRSVLWALFGSAGLALAAIGVWWALAHSGVVRVAAAILSVATPVAVLALYATAGLLGPALLSLGLLILAVIAARWALAPAPTTGEQVAEAPHHPWVLVNRLSGGGKVDRFALVDKARNAGCRVRELDRDQDVTTLARQAVADGADLLGAAGGDGTQALVADVAARHHVPFAVIPAGTRHHFALDLGLDRDDPVAALEALTGGVELRVDLGYAADRVFVNNASFDTYAFVVDDPAYRGAKTRTILQNLPGLLTGEAAPDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IX4</accession>
    <name>Q93IX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1296</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625582.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027703.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1296"/>
    <dbReference type="GeneID" id="1096719"/>
    <dbReference type="KEGG" id="sco:SCO1296"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1297"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018914_3_0_11"/>
    <dbReference type="InParanoid" id="Q93IX4"/>
    <dbReference type="OMA" id="MPVDEIH"/>
    <dbReference type="PhylomeDB" id="Q93IX4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="562" mass="62548" checksum="6242808E13A1E501" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IX8</accession>
    <name>Q93IX8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625578.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027700.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1292"/>
    <dbReference type="GeneID" id="1096715"/>
    <dbReference type="KEGG" id="sco:SCO1292"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1293"/>
    <dbReference type="eggNOG" id="ENOG5033SDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016093_0_0_11"/>
    <dbReference type="OMA" id="DCAERSG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045472">
        <property type="entry name" value="DUF6493"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20103">
        <property type="entry name" value="DUF6493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="26"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6493" evidence="1">
        <location>
            <begin position="698"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="907" mass="96787" checksum="D149FDB39C7B53D0" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J74</accession>
    <name>Q93J74_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2823</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975977.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2823"/>
    <dbReference type="GeneID" id="1098257"/>
    <dbReference type="KEGG" id="sco:SCO2823"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2881"/>
    <dbReference type="eggNOG" id="COG3473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068086_2_0_11"/>
    <dbReference type="InParanoid" id="Q93J74"/>
    <dbReference type="OMA" id="WKVNYRT"/>
    <dbReference type="PhylomeDB" id="Q93J74"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="31221" checksum="4203C7823BAB60E9" modified="2001-12-01" version="1">MDISFLGGPAPQRGVGVVAPFDFALDRELWRWVPDDVSLHMTRTPFVPVEVSLDLARMVSEHETLGEAVRTLNAIAPEVVAYACTSGSFVGGIAGERAMCEAMTWAGAVPSVTTSGALLDALAELGVRRVALVTPYTVSVTRALEAYVAEAGVTVTGCAFMGLTRHIWKVPYRDVADMARQAVPAPGAADALFISCTNLPTYDVIPQLEAELRIPVISANQVTMWAALRRLGTPAVGPYQALTDPAARLGPAATGAVGPAVVGPPGPVDPAVAGPVGPAAVDMPGVGDVPDTEQQQEGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RU6</accession>
    <name>Q93RU6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative secreted pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1880</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626147.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028028.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1880"/>
    <dbReference type="CAZy" id="PL1">
        <property type="family name" value="Polysaccharide Lyase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1097314"/>
    <dbReference type="KEGG" id="sco:SCO1880"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1905"/>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_3_0_11"/>
    <dbReference type="InParanoid" id="Q93RU6"/>
    <dbReference type="OMA" id="GNWNSQY"/>
    <dbReference type="PhylomeDB" id="Q93RU6"/>
    <dbReference type="BRENDA" id="4.2.2.2">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176595" evidence="4">
        <location>
            <begin position="35"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Amb_all" evidence="5">
        <location>
            <begin position="138"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="444" mass="47732" checksum="862FB8F3CF1E0818" modified="2001-12-01" version="1">MSTQRWHGHATKRAAALVGCTALVLSLTAATAEARPGHHHPRDTARQTLPAGDGWASQGPGTTGGSAADAEHVYTVSTWAEFRAALAADGTAPRIIKVKGTVDAVSEGCEAFAAPGYDFDAYLEKYSPENWGMDTDLSAEPDDSPEGLRRVSAARQDRTIKANVPSNTTIIGVGRGAALKGASLQIKGVDNVIVRNLTFESPVDCFPQWDPTDGDRGNWNSEYDSAVVYGSTHVWLDHNTFTDGEHPDSAAPTYFGMLYQQHDGQLDIVKGADYVTASWNVFTEHDKTILIGNSDSESTAAVDRGHLRATFHHNLFKNLVERAPRVRFGQVDVYNNHFVASDDYAYSFGVGKESALVAEHNAFTLPAGVSPAKVLKRWNDSPLSAAHNRVNGRTVDLIAAHNAENPDAVLRSGAGWTPSLRTKVLPARAVPFVVDHGAGAGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q93S08</accession>
    <name>Q93S08_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6281</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630379.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030793.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6281"/>
    <dbReference type="GeneID" id="1101722"/>
    <dbReference type="KEGG" id="sco:SCO6281"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6397"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_2_0_11"/>
    <dbReference type="InParanoid" id="Q93S08"/>
    <dbReference type="OMA" id="WIQLVTH"/>
    <dbReference type="PhylomeDB" id="Q93S08"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176600" evidence="2">
        <location>
            <begin position="36"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="70"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC37882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="545" mass="58522" checksum="4D72C37A5433B76A" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q82</accession>
    <name>Q99Q82_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.284</name>
        <name evidence="2" type="ordered locus">SCP1.69c</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="17510" last="17515">
            <title>2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining.</title>
            <authorList>
                <person name="Corre C."/>
                <person name="Song L."/>
                <person name="O'Rourke S."/>
                <person name="Chater K.F."/>
                <person name="Challis G.L."/>
            </authorList>
            <dbReference type="PubMed" id="18988741"/>
            <dbReference type="DOI" id="10.1073/pnas.0805530105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639644.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639894.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039370.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095148"/>
    <dbReference type="GeneID" id="1095367"/>
    <dbReference type="KEGG" id="sco:SCP1.284"/>
    <dbReference type="KEGG" id="sco:SCP1.69c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8018"/>
    <dbReference type="HOGENOM" id="CLU_2107566_0_0_11"/>
    <dbReference type="OMA" id="GPAYRKC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010147722" evidence="1">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="11827" checksum="9BDCE28C847EE8CC" modified="2001-06-01" version="1">MLAAVVAVLAVTPAAAAPSVAAPSAASVPNAKACAKKWEVIGSKVAVRMPEGNKPVASPDSPVVRYLHRGDVVTSCVEALARTQSGPAYRKCGKDGHVWRIVRGGQVPATCLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACR4</accession>
    <name>Q9ACR4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.254c</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639864.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039556.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095337"/>
    <dbReference type="KEGG" id="sco:SCP1.254c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8199"/>
    <dbReference type="HOGENOM" id="CLU_116750_0_0_11"/>
    <dbReference type="OMA" id="DEWFFEV"/>
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        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="207" mass="22966" checksum="DD85BA8797CD9FA6" modified="2001-06-01" version="1">MQHQGVCTRADMLRFRGEDEWFFEVTGYLQNWSVQAARDAIAADTDLLLPLVDDSDPTMRIAAAYALAAASARAQTIVSVFQTRLLCEDVPAVRAGLVLAIAQLARVHQNSNTVVWMQACWSDHVQPREVRVSAALGWMCLTDLPVPDELAALLDHLATHETAQLMAPLPWMRAAEHAAGNGLQRCLRTMLHPDTPDAEDRRDDPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACY7</accession>
    <name>Q9ACY7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.164c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639737.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095242"/>
    <dbReference type="KEGG" id="sco:SCP1.164c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8110"/>
    <dbReference type="HOGENOM" id="CLU_046006_6_1_11"/>
    <dbReference type="InParanoid" id="Q9ACY7"/>
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    <dbReference type="PhylomeDB" id="Q9ACY7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="14100" checksum="81C6ADF2B6F7BE7D" modified="2001-06-01" version="1">MEASLSFVHHLGVFASDFEASERFYTAALEPLGISAGYRADGVAEYWHPKRDTPSLSLERAEKVTAATRGMHIAFTAGSRDAVDAFHVAAVAAGGTSRHAPRSWSEYRAYCSFVSDPDGNNIEAVHKEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD04</accession>
    <name>Q9AD04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="1095224"/>
    <dbReference type="KEGG" id="sco:SCP1.146"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8093"/>
    <dbReference type="HOGENOM" id="CLU_015591_1_0_11"/>
    <dbReference type="InParanoid" id="Q9AD04"/>
    <dbReference type="OMA" id="MAANIRW"/>
    <dbReference type="PhylomeDB" id="Q9AD04"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015040">
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="848" mass="92501" checksum="0B3946C8850F6B64" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD18</accession>
    <name>Q9AD18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.132c</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639705.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039431.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095210"/>
    <dbReference type="KEGG" id="sco:SCP1.132c"/>
    <dbReference type="HOGENOM" id="CLU_1509724_0_0_11"/>
    <dbReference type="OMA" id="RIDEVFW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="19229" checksum="0880F079548F6C46" modified="2001-06-01" version="1">MSLDWATTITTVGGVAATLIGVVSGSLLTSRTNRMHWSRDKQIDACSAIVAESTRIQLALRRAWKHGDSVDWVPWNVALGTIWLVGSPAVAKAAARIDEVFWEYSDQFIQQTASSEQTWGRARDQMEAARLAFINTARLYVDPQHTPLDQAPVARPPLPGTGTSVITSDPEAGAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD19</accession>
    <name>Q9AD19_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.131</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639704.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039430.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095209"/>
    <dbReference type="KEGG" id="sco:SCP1.131"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8079"/>
    <dbReference type="HOGENOM" id="CLU_1045515_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="29085" checksum="3FB2F8482B8B91E5" modified="2001-06-01" version="1">MPDFAHDEATARRALDVIDQLLAARDRVVSGVDGIAFLREYEAVAPVAWSWWMLITDSARVVAEAAKNGDGFVVAPVMRNLMTHAVAMAWLVDGGDAAVQAVDAYSDDQLLRLIANAKRAGWDVEGDEVEARVRAAVAERTATPDPDVVRLTNEIRNTADLMSAFGLQEGYLPYRHLSSYSHTTRETAQLYLHRTESGGWALRGKPRESGLNDVIWTAVCLIQAGRILDSILTGQPLTESLDRTTAHLGVLGDIVPRRRARRGAGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADA4</accession>
    <name>MSHC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName>L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber>6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Mycothiol ligase</fullName>
            <shortName>MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mshC</name>
        <name type="synonym">cysS2</name>
        <name type="ordered locus">SCO1663</name>
        <name type="ORF">SCI52.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Mol. Microbiol." volume="68" first="861" last="870">
            <title>Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and sigma(R) in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Park J.H."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="18430082"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06191.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Gradually induced by thiol-oxidant diamide, under (probably indirect) control of SigR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC36366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625938.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977162.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ADA4"/>
    <dbReference type="SMR" id="Q9ADA4"/>
    <dbReference type="STRING" id="100226.SCO1663"/>
    <dbReference type="GeneID" id="1097094"/>
    <dbReference type="KEGG" id="sco:SCO1663"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1680"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADA4"/>
    <dbReference type="OMA" id="HAWPASE"/>
    <dbReference type="PhylomeDB" id="Q9ADA4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035446">
        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01697">
        <property type="entry name" value="MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017812">
        <property type="entry name" value="Mycothiol_ligase_MshC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03447">
        <property type="entry name" value="mycothiol_MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159491" description="L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'ERGGDP' region">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18430082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="409" mass="44186" checksum="F0A2F56AD7C84579" modified="2001-06-01" version="1">MHAWPASEVPALPGQGRDLRIHDTATGGPVTLDPGPVARIYVCGITPYDATHMGHAATYNAFDLVQRVWLDTKRQVHYVQNVTDVDDPLLERAVRDGVDWTALAEQETALFREDMTALRMLPPQHYIGAVEAIPGIVPLVERLRDAGAAYELEGDVYFSVEADPHFGGVSHLDAATMRLLSAERGGDPDRPGKKNPLDPMLWMAAREGEPSWDGGTLGRGRPGWHIECVAIALDHLGMGFDVQGGGSDLAFPHHEMGASHAQALTGEFPMAKAYVHAGMVGLDGEKMSKSKGNLVFVSQLRREGVDPAAIRLTLLAHHYRSDWEWTDQVLQDALARLDRWRAAVSRPDGPPAEALVEEIREALANDLDSPAALAAVDRWAALQQESGGTDIGAPGVVSRAVDALLGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADF9</accession>
    <name>Q9ADF9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630212.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972816.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6104"/>
    <dbReference type="GeneID" id="1101545"/>
    <dbReference type="KEGG" id="sco:SCO6104"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6207"/>
    <dbReference type="eggNOG" id="ENOG502ZC09">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570970_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADF9"/>
    <dbReference type="OMA" id="VWYQDKL"/>
    <dbReference type="PhylomeDB" id="Q9ADF9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176611" evidence="1">
        <location>
            <begin position="37"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="437" mass="46246" checksum="71A00E5AE5E5B120" modified="2001-06-01" version="1">MKQRGRHRRRRRGRALRAALTGAALALTGAATLISASQATVADDPGALKPLTSAAETDALRLTEHRVPTAWLDRLSAAMGDPVGVDTVLESADHTLRDAADCTAGEREALPVSPAATRAYCWDEADTDGWRPGAVTTSGDADEDGRWGAHRVILSAWSRDDGTPQGGLARVSFVDADDPGRLGYASALLAVPVDGGHDYRGLASPVTGMVWYQDKLLVTTAAGDRDALYVYDVERVQRATTAADAVGRVPGGWAAGGHRYVLPAIASYRLPDTDGAARPAAISLDRGTSPDSLVATERVAADGDRPTRLWRYALRTATDPDRTGLPATDPSGRVDAVEAYETGAAEVGGVLSHRPPGATRSDWYLGRAAGGQEGRGTLWRQDTEGARAAECGADRSQQCWSGPAGSMSYWERTGEVWSQSGRMLFALPLTSIEDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWG7</accession>
    <name>Q9EWG7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4971</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629123.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029980.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9EWG7"/>
    <dbReference type="STRING" id="100226.SCO4971"/>
    <dbReference type="GeneID" id="1100412"/>
    <dbReference type="KEGG" id="sco:SCO4971"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5051"/>
    <dbReference type="eggNOG" id="COG4630">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_9_0_11"/>
    <dbReference type="InParanoid" id="Q9EWG7"/>
    <dbReference type="OMA" id="AFHKIAK"/>
    <dbReference type="PhylomeDB" id="Q9EWG7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012175">
        <property type="entry name" value="Xanth_DH_ssu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036557">
        <property type="entry name" value="XdhA_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="213"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD30956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="497" mass="52554" checksum="66F8B9BB40A532D0" modified="2001-03-01" version="1">MVTARITVNGKESPIAPAAPHTTVLDFLRERGLTGTKEGCAEGECGACSVLVARPGVNKPTDWVPVNACLVPVAALDGQEVVTSEGLATVEAPGTPPVLHPVQEEMAVRGGSQCGYCTPGFVCSMAAEYYRPDRCAHADPGPDATAAADGAEGGDAEHGPNGFDLHALSGNLCRCTGYRPIRDAAFAVGTPTDEDPLARRREQDPPAPVATEYRQDDSAFLRRSTLAETLRLLRERPQAVVVAGSTDWGVEVNIRSRRADCVVAVDRLPELRDLRVESDHVEIGAALTLTEIERRLDGSVPLLAQLFPQFASRLIRNGATLGGNLGTGSPIGDSPPVLLALEASLVLADADGEREVPLADYFTGYRQSVRRPGELIRAVRVPLPLSPVTAFHKIAKRRFDDISSLAVAFALDVEGGTVRKARIGLGGVAATPVRALATEAALEGRPWTTGTAEAAAEVLRGEGTPMSDHRASARYRAAMLGQSLLKLYAQTTEAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWK2</accession>
    <name>Q9EWK2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7791</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031914.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7791"/>
    <dbReference type="GeneID" id="1103228"/>
    <dbReference type="KEGG" id="sco:SCO7791"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7907"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EWK2"/>
    <dbReference type="OMA" id="FPFADRP"/>
    <dbReference type="PhylomeDB" id="Q9EWK2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="401" mass="43512" checksum="06C5C70456CAFE58" modified="2001-03-01" version="1">MTAMQKRALVVGLGIAGMSAAIGLRRAGWTPVIVERAPERRTGGYFVGLFPEGRQAAVDLGIADHLHTRNPERAAGTNAWSVDRRGRRRPALGFLDQPGGPAAVLRGDIEAALWQSITGVEVRFATTPVAITEGPAEAQVLLEHADTGGQYRESFDLVIGADGMRSSVRRMVFGPHEDHLTTWNAMICAFQLKEQAPTYEASDSIIIARAKRAVWVFGLADHAPTALLTYRTTDIQEQFSGSRLERLRAVFSGMDDPTVRHVLDSLEEAPDHVFDSVHQVRMPRWSTGRVVLVGDAAWCMNLYSGMGATSSLRGGAALGAALQEHPDDLAAALDAWEAGLRPFITKHQRAARLKQQMFVPSSRRAEALRSVLVGLARRVRGRQSATESGGPQDVALSGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWK6</accession>
    <name>Q9EWK6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7787</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631817.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031910.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7787"/>
    <dbReference type="GeneID" id="1103224"/>
    <dbReference type="KEGG" id="sco:SCO7787"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7904"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2235076_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="122" mass="13632" checksum="EAA7470EF39FF49C" modified="2001-03-01" version="1">MERRPCTFRRSNGITLSVSLVHPVVTGEIGWSAAAMAKQGHVPLVTFWWCRDQLSEAAARISVSVQFLVQWDDERVPRVQSLALFDALASTERTSHANPGKHGETPAFELESTLRFFARHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWV1</accession>
    <name>Q9EWV1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4915</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629068.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029946.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4915"/>
    <dbReference type="GeneID" id="1100356"/>
    <dbReference type="KEGG" id="sco:SCO4915"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4994"/>
    <dbReference type="eggNOG" id="ENOG50332AI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086376_0_0_11"/>
    <dbReference type="OMA" id="KYQLWAI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="24703" checksum="7E13DF556AEC229F" modified="2001-03-01" version="1">MTTPEPQSSSPQPSGPVSKDRAYRSPAGISGGVLVLALALWLGIDALVTGEGDTRWKALAALVFLVPLVAAYTVRPAVFANDDRMRVRNPFRVIVLPWAQVESFRSAYSNEVFTEGGDKFQLWSVPVSLRGRKKAARQEDRRLAGGTGGRRRGSVLGGVGQFGSRGGGAGASAVEGEGPVRAEADKVMDELRELWEARKAAEGSQGGVTVRWAYEIVVPVVAGAVALGVLFGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX05</accession>
    <name>Q9EX05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1121</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625414.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027588.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1121"/>
    <dbReference type="GeneID" id="1096544"/>
    <dbReference type="KEGG" id="sco:SCO1121"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1118"/>
    <dbReference type="eggNOG" id="COG3652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079636_0_1_11"/>
    <dbReference type="OMA" id="LWSYADR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025419">
        <property type="entry name" value="DUF4142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13628">
        <property type="entry name" value="DUF4142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176647" evidence="2">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4142" evidence="3">
        <location>
            <begin position="54"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC13073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26309" checksum="BD3EFFCC928EF4B8" modified="2001-03-01" version="1">MRITRTTAGTAFVAGALVLTLTALAYPAMLGVQNAGSDQARVVTNTRYGPLTEQDRDFVVKVRAAGLWEHPLGLMAIERGTTPEMREAGEHLVVGHSRLDATCRRIAPELGITLPNLASPQQQQFVSTVNGTTGKQFDTTAVNIMRITHGQIFPAIANIRANTKNSLVRQLADQANDTVLDHITVLEKTGLVNFDQVNFQQTAPPNLPTAQLTPPAPQPGEPVLSLTAPPGLEVNTSAPTPSPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2M4</accession>
    <name>Q9F2M4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3757</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627947.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029215.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3757"/>
    <dbReference type="GeneID" id="1099193"/>
    <dbReference type="KEGG" id="sco:SCO3757"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3817"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9F2M4"/>
    <dbReference type="OMA" id="HHMSVIT"/>
    <dbReference type="PhylomeDB" id="Q9F2M4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC10295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="47917" checksum="D5CF4D2674B571B0" modified="2001-03-01" version="1">MRPSRRRLFRRRRGAHRAPRLVPMIPVEAERPRALLAGASRRWVRLLPWAVAFVLCVALLPTTIVVLTADYGLNGGLASALAVAQAAPLLLAVVRPLQAWYVVFVADVAGALALLTVDFQERLLWPFPPMEIVGYVGLCLALGLRERRRTLLLVWLATAGANVGLGFAAPHGTGAKDLLLTILGGVALLLGGALRERYEVQRRLAEQETISEAERGRRTLLEERARIARELHDVVAHHMSVITVQADTAEYRLAALPPDVREEFTSIAATARESLGEMRRLLGVLRNEEAHGELVPQPGLAQIGQLVEATARTVGPVDFTGCDAEVPEAVGLSAYRIVQEALANVVRHAPGAATHVSLSVARPAGGQGDGQTDGQREGPGGERLTVLVVNEPPPEPPAGPLEVGGTGHGLVGMRERVRLVGGTLDVGPLPDGGFRVAAQLPLTEEDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3D0</accession>
    <name>Q9F3D0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RibD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7627</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631668.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031787.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7627"/>
    <dbReference type="GeneID" id="1103065"/>
    <dbReference type="KEGG" id="sco:SCO7627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7746"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_1_11"/>
    <dbReference type="InParanoid" id="Q9F3D0"/>
    <dbReference type="OMA" id="GPEYLAW"/>
    <dbReference type="PhylomeDB" id="Q9F3D0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="193" mass="21253" checksum="31306E1DC1424B2A" modified="2001-03-01" version="1">MASLMVDFIISLDGYAAADGWPGFWGMEGPEYLAWLDGDAEKQHTSLMGATTYRLMSGFAREMPDDPGFEGITAMPKVVFSSTLRTPLSWDNTELVPGDPVPAVRDMKRHGTRPLRTLGSLTLCRSLLRAGLVDRFRVVVFPVITGATGRERIFDQYPDVTLDLVGSRTFDGRLQLLEYVPTVLDGPPGADQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3K2</accession>
    <name>Q9F3K2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5263</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629409.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030137.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5263"/>
    <dbReference type="GeneID" id="1100704"/>
    <dbReference type="KEGG" id="sco:SCO5263"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5347"/>
    <dbReference type="eggNOG" id="ENOG5033F1S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090963_2_1_11"/>
    <dbReference type="OMA" id="HIGDEHI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC05956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="188" mass="20201" checksum="0951EFC4CA27FC36" modified="2001-03-01" version="1">MFERFTKDARAVVQGAVGHAEEARAETVEPEHLLLALLDREGSRASFALAALGVGEHRDAVRRELGDARRRAGLSQSETEALAGLGIDVTEIVARVEEAHGVGAMSADDRKRGRRWSGHRSFSRGAKEVLEKALRVAVARRDRHIGDEHLLLALALRPGVPAEVLADHGVTHASLSRVLDEGAGKSCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-31" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBM1</accession>
    <accession>Q9ADE9</accession>
    <name>ISPH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="1">HMBPP reductase</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH</name>
        <name type="synonym">lytB</name>
        <name type="ordered locus">SCO5058</name>
        <name type="ORF">SCBAC20F6.01</name>
        <name type="ORF">SCK7.31</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD55221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733653.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973920.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FBM1"/>
    <dbReference type="SMR" id="Q9FBM1"/>
    <dbReference type="STRING" id="100226.SCO5058"/>
    <dbReference type="GeneID" id="1100499"/>
    <dbReference type="KEGG" id="sco:SCO5058"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5137"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FBM1"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="PhylomeDB" id="Q9FBM1"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:terpenoid biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="lytB_ispH"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LYTB"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
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    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
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        <ligand>
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            <position position="83"/>
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        <ligand>
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        <location>
            <position position="105"/>
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        <ligand>
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        <ligand>
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            <position position="203"/>
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            <name>[4Fe-4S] cluster</name>
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        </ligand>
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        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="338" mass="36609" checksum="07EDFF4D2D938E98" modified="2002-01-31" version="2">MGAMTASPGRRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPVYVRHEIVHNKYVVQTLEKKGAIFVERTEEVPEGNIVMFSAHGVAPVVHEEAERGKLATIDATCPLVTKVHKEAVRFANDDYDILLIGHEGHEEVIGTSGEAPDHIQLVDGPEDVAKVEVRDPSKVVWLSQTTLSVDETMETVDALKDKFPQLISPPSDDICYATQNRQLAVKQMGAEAELVIVVGSRNSSNSKRLVEVAKQAGSRAAYLVDFADEIDETWLDGVTTVGVTSGASVPDVLVEQVLEWLSRRGFEDVEIVKAAEESIIFSLPKELRRDLREEAASLVAERGGSGTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC14</accession>
    <name>Q9FC14_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC01568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="CAZy" id="GH75">
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO7070"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7175"/>
    <dbReference type="eggNOG" id="COG3409">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC01568.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="39748" checksum="356E064460C77267" modified="2001-03-01" version="1">MGDDHSEGLRMLSHRTAELPAASGKFGPVARGPLSSPSRAGAGGRAGRSRNRPGPPAPGPAPPTHRAHGGRAPSGPAQGGRAGVSGTDEAECPSMPPRRGHIVRVQSLTLVAASAALLAPTTFPGAPPPPLPEPPAQLLLPGAPDRPGPLRADRSGVRIGPVPHVPAGQPAPHVRQRTDSGPEAGPRAQRDASGSPVRAADLLARVRDCDPVSRGRYRSDAGAPADIPVCGTKEAVYWKADLDVDCDGRPGDRCNSGTDPHFSPATAYTGSDGRPLDAERLPYVVVPGPSDTWDHREDGVRGGSLAALVHGDRVRYAVVGDVGPSDLIGEASYAAARSLGIPADPEGGGVASDVTYIVFKGSQVEPIDDTAAAEKAGERLARRFVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCA3</accession>
    <name>Q9FCA3_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1210</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC01492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1210"/>
    <dbReference type="GeneID" id="1096633"/>
    <dbReference type="KEGG" id="sco:SCO1210"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1209"/>
    <dbReference type="eggNOG" id="COG1309">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_1_11"/>
    <dbReference type="InParanoid" id="Q9FCA3"/>
    <dbReference type="OMA" id="GMMHAAG"/>
    <dbReference type="PhylomeDB" id="Q9FCA3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
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        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="23891" checksum="3808D1E22055D842" modified="2001-03-01" version="1">MNTTQRADQQTSADRRRRELLEAADRVVLRDGPHASMNAIAAEAGITKPILYRHFGDKGGLYAALAVRHTDALLASLRAALDAPAQRRQRVEATLDTYLAAIEARPQVYRFLMHPAESAGTPGDQSEQGFDVGKHSAPLLRRMGEELAQVIEERLDVGPGTQQLARVWGHGIVGMMHAAGDWWLGERPCPREELVRTLADLLWGRLAEAGDKEGGPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3I9</accession>
    <name>Q9K3I9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycine betaine ABC transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4831</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB97434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628987.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029894.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4831"/>
    <dbReference type="GeneID" id="1100272"/>
    <dbReference type="KEGG" id="sco:SCO4831"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4907"/>
    <dbReference type="eggNOG" id="COG4176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023562_0_3_11"/>
    <dbReference type="OMA" id="MQVLPAF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005275">
        <property type="term" value="F:amine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015226">
        <property type="term" value="F:carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015871">
        <property type="term" value="P:choline transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
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            <begin position="143"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="457"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB97434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="648" mass="67234" checksum="A39E44E3B8AE3F5C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3S1</accession>
    <name>Q9K3S1_STRCO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3143</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB95936.1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="55" mass="5716" checksum="0090BAF72875629A" modified="2000-10-01" version="1" fragment="single">TDSAPFRGRTPPGAPPTHPPDKPRYPHPHHPAQAAAGTPAQPPEAPARSSNPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4B8</accession>
    <name>Q9K4B8_STRCO</name>
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        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding subunit</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="ordered locus">SCO5393</name>
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    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5393"/>
    <dbReference type="GeneID" id="1100833"/>
    <dbReference type="KEGG" id="sco:SCO5393"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5474"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9K4B8"/>
    <dbReference type="OMA" id="HVTIGGH"/>
    <dbReference type="PhylomeDB" id="Q9K4B8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB94564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="423" mass="44002" checksum="32100C18FABB6466" modified="2000-10-01" version="1">MIEAVGLTKRYGDKTAVYNLSFQVRPGAVTGFLGPNGSGKSTTMRMILGLDNPTAGHVTIGGHPYRRLPNAARHVGALLDAKAVHGGRAARNHLLSLAQLSGIPARRVDEVLGVVGLQDVAKRRSKGFSLGMGQRLGIAAALLGDPQVLLFDEPVNGLDPEGIHWVRNLMKALAAEGRTVFVSSHLMSEMALTADHLIVIGRGQLMADMSVTDFISANSADFARVRTPDTEPQLREKLTSALTEAGGHVLPEQDGALRVTGLALPRISDIAHDTDVRLWELSPHQASLEEAYMRMTQGAVDYRSTADQKAGLQQPLPPGAQPPMPVAGQGQPGWYAPPPPQQGGQPFAAPQGAPGQAPAGPYGAPVAPGAVPGGQPANPYAARQAPQAPPMPQAPAGAPTPPAAGPAPAAAPVTDPTKPEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4H2</accession>
    <name>Q9K4H2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628342.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029477.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4166"/>
    <dbReference type="GeneID" id="1099606"/>
    <dbReference type="KEGG" id="sco:SCO4166"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4231"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160043_0_0_11"/>
    <dbReference type="OMA" id="EWWDELD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="97" mass="10929" checksum="E651D0725927E628" modified="2000-10-01" version="1">MSGPGVRTYAGGMYARRRHVYFAMMGTCIVLFVLAWGVVRLWSVPAAVGLCVFTMLIPPVAAMVANRRGPDDRWWDDPSGDAQSDEWWDELDGKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4H3</accession>
    <name>Q9K4H3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4165</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628341.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974805.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4165"/>
    <dbReference type="GeneID" id="1099605"/>
    <dbReference type="KEGG" id="sco:SCO4165"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4230"/>
    <dbReference type="eggNOG" id="ENOG5032Y6I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154652_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4H3"/>
    <dbReference type="OMA" id="MCTAPKQ"/>
    <dbReference type="PhylomeDB" id="Q9K4H3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="95" mass="9685" checksum="1277AC0B6BCD1903" modified="2000-10-01" version="1">MCGAKAGGPDASTIKPGETTIQGQVTRDGEPVTGYVRLLDATGEFTAEVPTSATGQFRFYAAEGTWTVRALIPGGTADRTVVAQQGGLAEVAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4H8</accession>
    <name>Q9K4H8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7247</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631303.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971898.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7247"/>
    <dbReference type="GeneID" id="1102685"/>
    <dbReference type="KEGG" id="sco:SCO7247"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7347"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_2_3_11"/>
    <dbReference type="InParanoid" id="Q9K4H8"/>
    <dbReference type="OMA" id="VHVRQYA"/>
    <dbReference type="PhylomeDB" id="Q9K4H8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="154"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="31307" checksum="9D6ED50657C8157B" modified="2000-10-01" version="1">MSTLPVIAAVDGSDDGLRALDWALDAAHRRGAPLRVVHVRQYAAWAQTDVLVAGPPDTAEDPALDQARAHLQGRAFAVPTEYVGMEGVPGALLPELGADAQLLVLGSRGRGGFAGLLLGSNGMAAARDAQCPVVVVPRPGREVHGEAPAEPGPRVVVGLHVDSPDDATLSFAFTEAELRGARLQVVAAYPWPVQTWAAAGQMMPLVIDEVSIESETRVLADGLLAPYRGRHPDVRADTHAVPGDAAGNLVASSKDADLIVVGRHRRRLLAPARMMGSVTHAVLLHAAAPIAVVPPAPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXJ3</accession>
    <name>Q9KXJ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2327</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626574.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976486.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2327"/>
    <dbReference type="GeneID" id="1097761"/>
    <dbReference type="KEGG" id="sco:SCO2327"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2364"/>
    <dbReference type="eggNOG" id="ENOG5031WYH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157317_0_0_11"/>
    <dbReference type="OMA" id="HRANFET"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB93447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="128" mass="13857" checksum="25DAB33DAE155487" modified="2000-10-01" version="1">MILHHLVLDAPTLVALSGNRQVSALIHRANFETETRLWVPALSVLEAERELLGITEHVGQLDVMHTVDLDYPAVLAVAQLSRDGVPPGIGAAIHAARHLPEWGADALIATVAPKAYEERGLPVLDLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXJ7</accession>
    <name>Q9KXJ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2323</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626570.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028280.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2323"/>
    <dbReference type="TCDB" id="3.A.1.32.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1097757"/>
    <dbReference type="KEGG" id="sco:SCO2323"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2360"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033425_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXJ7"/>
    <dbReference type="OMA" id="AWWLWAL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB93443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="39360" checksum="CDDEB75B5ED7D068" modified="2000-10-01" version="1">MGAGGTPSAPASVPTPARHQRRGALHPGAWWLWALGLGTAATRTTNPLLLTLLVTVSAYVVVTRRPHAPWSRSYGAFVKLALAVLLIRLLFTTLLGSPIPGTHTLLTLPEVPLPDWAQGIRLGGRVTAEGLTFALYDAMKLATLLICVGAANALANPARLLKSLPGALYEMGVAVVVALTFAPNLIADVQRLRAARRLRGRPDRGVRGLLQVGLPVLEGALERSVALAAAMDARGYGRTAHVPAPVRRTTAALTLGGLLGVCAGTYGLLTAAGGTYGIPVLLAGVAAAVAGLWLGGRRTVRTRYRPDRWDARAWLVTASGATVAALLFLAAARDPAALHPGVVPLEAPTLPLWPAAAVLVGLLPAFITPVPEAAVKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXM4</accession>
    <name>Q9KXM4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628504.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029585.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4333"/>
    <dbReference type="GeneID" id="1099773"/>
    <dbReference type="KEGG" id="sco:SCO4333"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4403"/>
    <dbReference type="eggNOG" id="ENOG5033M5J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150710_1_1_11"/>
    <dbReference type="OMA" id="QLPFYGW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="86" mass="9607" checksum="F8CBF8AAAB667DF0" modified="2000-10-01" version="1">MTKWTPTHEAPEPLEGPVVPTIVGGTILWFVLFLVQLPFYGWFDDHGHTWWVWTCLAGAGLGLIGIWYVRGRDAAIRRDTAAGAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXN4</accession>
    <name>Q9KXN4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4323</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628494.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029580.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KXN4"/>
    <dbReference type="STRING" id="100226.SCO4323"/>
    <dbReference type="GeneID" id="1099763"/>
    <dbReference type="KEGG" id="sco:SCO4323"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4392"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_22_0_11"/>
    <dbReference type="InParanoid" id="Q9KXN4"/>
    <dbReference type="OMA" id="AKYEPNA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB93397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="22977" checksum="F9654CA740B32F92" modified="2000-10-01" version="1">MASTTRPAPTVGFDLDMTLIDSRPGIRACYVELSARTGTYVDADLAVTRLGPPLAEELANWFPAEEIEAVADLYREIYPAYAIEPTLALPGAREAVTAVRGAGGRAVVVTAKYEPNAKLHLAHLGIEPDAVIGGLWAEQKAVALREHDADVYVGDHVGDVRGARAAGARSVAVASGPCDAGELRAAGADVVLADLTAFPEWLAAYRDGEGDAEGLDAARA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-13" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXQ6</accession>
    <name>AROB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate synthase</fullName>
            <shortName evidence="1">DHQS</shortName>
            <ecNumber evidence="1">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroB</name>
        <name type="ordered locus">SCO1494</name>
        <name type="ORF">SC9C5.18c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625774.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027813.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXQ6"/>
    <dbReference type="SMR" id="Q9KXQ6"/>
    <dbReference type="STRING" id="100226.SCO1494"/>
    <dbReference type="PRIDE" id="Q9KXQ6"/>
    <dbReference type="GeneID" id="1096920"/>
    <dbReference type="KEGG" id="sco:SCO1494"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1503"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_3_11"/>
    <dbReference type="InParanoid" id="Q9KXQ6"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="PhylomeDB" id="Q9KXQ6"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000140790" description="3-dehydroquinate synthase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <sequence length="363" mass="38170" checksum="7F0CF03C6AB0566D" modified="2000-10-01" version="1">MSEAVTRIQVGGTAGSEPYEVLVGRQLLGELGGLIGAKAKRVAVIHPEALAETGDALRADLAAQGYEAIAIQVPNAEEAKTAEVAAYCWKALGQSGFTRTDVIVGVGGGASTDLAGFVAATWLRGVRWIAVPTTVLSMVDAAVGGKTGINTAEGKNLVGSFHPPAGVLCDLAALDSLPVNDYVSGLAEVIKAGFIADPAILDLIEADPQAARTPAGPHTAELIVRSIKVKAEVVSSDLKEAGLREILNYGHTLGHAIEKNERYKWRHGAAVSVGMHFAAELGRLAGRLDDATADRHRSILEAVGLPLHYRYDQWPKLVENMKVDKKSRGDLLRFIVLDGLAKPTVLEGPDPAVLLAAYGEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY10</accession>
    <name>Q9KY10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631382.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971813.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7328"/>
    <dbReference type="GeneID" id="1102766"/>
    <dbReference type="KEGG" id="sco:SCO7328"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7431"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_22_0_11"/>
    <dbReference type="OMA" id="GGIGWHL"/>
    <dbReference type="PhylomeDB" id="Q9KY10"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="15875" checksum="6B234CBA82FDACFE" modified="2000-10-01" version="1">MAAESRWDRTLASEEITNRTASFTGELHNVTGARLVAEEFLHDLARAAPPAAPEHWDDILLVVTELAANAVQYAPGPFQLRLRRTFDGVHVVMHDTNTTEPAPRPFHPSKGGGGIGWHLIHTLSDQVSVVTGERGKDIHVFLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYD2</accession>
    <name>Q9KYD2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6898</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630967.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031283.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6898"/>
    <dbReference type="GeneID" id="1102337"/>
    <dbReference type="KEGG" id="sco:SCO6898"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7007"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_6_2_11"/>
    <dbReference type="InParanoid" id="Q9KYD2"/>
    <dbReference type="OMA" id="SVECVTY"/>
    <dbReference type="PhylomeDB" id="Q9KYD2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="405" mass="42989" checksum="16D94E62E983012C" modified="2000-10-01" version="1">MLVVAPGDESYRGYCLEQVADAYDVVLLTGAEPSWEKPHITDHAVVDLSDPAALLAGGRALAGRHDLAGVMTWDEWSVVPTARLARQLGLTTTAPEVMQGCRNKATARSLFARHGVPSAASVSVCTRQEAEAAAERIGYPVVLKPASHAGAIGVRRVDDRDQLTAAYRAAERTAGQGTESTSVLVEEFLDGPEISVECVTYRGTTTVVAVNRKAISPPPHFEQLAHSVDADDPLRETVAPAARAAINALGITDGVSHIEMRLVEGRPRLIEVNARLAGDMIGHLVRLATGIDLVRAAADIACDRAPELTPTRSSAAAIHLLYPDTSGTLTRLTYDGPSSNWLDRVQFQCRPGDQLLLPADGGNLYTGRIGYLITTATTGQQARTRADQAARAVTAVLDQTPGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYD7</accession>
    <name>Q9KYD7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4133</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628311.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974837.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4133"/>
    <dbReference type="GeneID" id="1099573"/>
    <dbReference type="KEGG" id="sco:SCO4133"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4195"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_8_0_11"/>
    <dbReference type="InParanoid" id="Q9KYD7"/>
    <dbReference type="OMA" id="VYMGVHY"/>
    <dbReference type="PhylomeDB" id="Q9KYD7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="69"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="25211" checksum="763AA9728C2EB15A" modified="2000-10-01" version="1">MAGLAESGSNPDVELLYDINGLAKDAPHWFDRVMEFVGEYGLLFAIVLLVLWCWWGVRRRGGEDAAPNVAALVWAPLAAGVAVLVNVPIRGFVERPRPFKSHEGLEVLVEGKNDFSFVSDHATLCMALAVGLFVANRKFGIAAIVLALFGGFARVYMGVHYPTDVVGGFALGTAVALLLSPVAMALLTPLTRAVERSPRVGWLISARGRSGAAGRGAVIPGARKESGAETSGERDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYE3</accession>
    <name>Q9KYE3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4127</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974843.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4127"/>
    <dbReference type="GeneID" id="1099567"/>
    <dbReference type="KEGG" id="sco:SCO4127"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4189"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024859_2_0_11"/>
    <dbReference type="OMA" id="AWHIINS"/>
    <dbReference type="PhylomeDB" id="Q9KYE3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="471" mass="51769" checksum="8C112B62B9214932" modified="2000-10-01" version="1">MRDPLTVLTDAFTSFLFGKVETTRLPVRTSTGQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYIYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVLRQLRFRDRQVVVLDAQGEDGVGEWNLIAEELGITPIRLDPMAALDHGIRLNPLDPAITTTGQLALLRTIIEVAMGHGLDERSGFALKVAHAYVNETIVERQPVLTDIVERLRHPEPESAEAMNVAIDDVRAWGLDVALVLDRLVDGDLRGMFDGPTTVGIDLDAPLIVFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAREAAAILKMASTRTIYAQKADEARATGRVLGLPRWAVEIIPSLTPGIAVWDVNGNVQVVKHLITETERPLVFTDRAMTESSADHLTDDALRAAELEAEERAAAFMEQHIGDSSESTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYP5</accession>
    <name>Q9KYP5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO4488</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB92109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628653.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029690.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4488"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1099928"/>
    <dbReference type="KEGG" id="sco:SCO4488"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4558"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029615_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYP5"/>
    <dbReference type="OMA" id="THGASAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF50370"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="10">
        <location>
            <begin position="507"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB92109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="626" mass="63134" checksum="6FD66E3D3A1E44FE" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYS3</accession>
    <name>Q9KYS3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5692</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB91128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO5692"/>
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    <dbReference type="OMA" id="PITEMPV"/>
    <dbReference type="PhylomeDB" id="Q9KYS3"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
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        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
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        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB91128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="36036" checksum="CCE95FE4C28327A8" modified="2000-10-01" version="1">MVTLAEVAQHAGVSASTVSYVLSGKRSISTTTRQRVEESIRKLGYHPNAGARALASSRSNIIALMIPLRTDMYVPVMMEIAIAVAAGARTHGYDILLLTGEEGPDAVRRVTGSGLADAMILMDVELDDERLPLLRDTHQPSVLIGLPADTEGLTCVDLDFRATGALCVEHLAQLGHRDIAVIGEAAAVYERHTGFAERTLDGLRTRARELGLRLLHRPCEGGYDAMSATLARVFDERPDTTGFVVQNESAVEPLLALLRQQGRAVPEDVSVVAVCPEQVATQASVRLTSVAVPAQEMGRRAVEQLVAKLDGRGSDEVVLLAPELTVRASSGPAPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZA3</accession>
    <name>Q9KZA3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628998.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974128.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4843"/>
    <dbReference type="GeneID" id="1100284"/>
    <dbReference type="KEGG" id="sco:SCO4843"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4919"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_7_1_11"/>
    <dbReference type="InParanoid" id="Q9KZA3"/>
    <dbReference type="OMA" id="QWAGVAV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="17378" checksum="698FD09D8B878218" modified="2000-10-01" version="1">MDDLDDMDHRIVSALRARGTDPRVAGAARALSWAGEHGALWLAAGLTAAAVDAPRRTAWLRGTALTAGAHVVSMGVKRVVRRPRPAHVVPLVRTAGRHSFPSSHATSAAAAAVVFGTLGVRAAWPLAAAVCASRLVVGVHYPSDVAAGAALGALTARLGADWMRGGTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZB0</accession>
    <name>Q9KZB0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gntR-family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4836</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628991.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029898.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4836"/>
    <dbReference type="GeneID" id="1100277"/>
    <dbReference type="KEGG" id="sco:SCO4836"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4912"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KZB0"/>
    <dbReference type="OMA" id="VEEPSYW"/>
    <dbReference type="PhylomeDB" id="Q9KZB0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="462" mass="48832" checksum="DF0ECDA651E13317" modified="2000-10-01" version="1">MANSWATLGVDLHLEPTGPGLRRGLTDALREAVRTGRLGPGTRLPSSRVLAADLGIARNTVADAYADLVAEGWLTARQGSGTRVADRVAAPPAEASARRPREPARPLHDLRPGSPDLASFPRVEWLRAARRAVTAAPNEAFGYGDPRGHPELRGALSAYLARARGVRAAPDHLLICGGVAHALVVLAAVLRARGVRTVAVESYGLHVHRDLLEAAGLRTVPLPVDDRGADPGALTDAGAVLLTPAHQFPTGVPLHPDRRAAVVDWARRTGALILEDDYDGEFRYDRQPVGALQGLAPDHVVYLGTASKSLAPGLRLAWAVLPPGLADEITATRGGSDTCGVLEQLTLAEFLASGAYDRHVRASRLRYRRRRDALVAALAGRVPEVRIAGIAAGLHAVLGLPPGTEQQVLRSAAWQGLGLHGLSVFRHPRATTDPLDAVVVGYGTPPDHAWTGALDALCRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZI0</accession>
    <name>Q9KZI0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625457.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027623.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1165"/>
    <dbReference type="GeneID" id="1096588"/>
    <dbReference type="KEGG" id="sco:SCO1165"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1163"/>
    <dbReference type="eggNOG" id="ENOG5032X99">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949687_0_0_11"/>
    <dbReference type="OMA" id="WDCGMEY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="305" mass="31184" checksum="16BBFEEA49BB1E36" modified="2000-10-01" version="1">MAGTDEDAVAAADDALYVLTAVLLTPAKFPSVLGDDYPEACAALGLPPLADGYGLVLGQDGDGARWTVVIDDVSLVAVAVASWDCGMEYDLSPDERTVVTALPGWPLAVAVAAPGVPVPHDPGPEVTDQPALCPPDTTVWGPPQRRLGADEIALQWAQWREQIDDADFSAPGGGAGSMEGAPGEGGEGDAGTGAGAPADTADQSVATDGRSGAKVSRHGGVRRVLAEARAYVDTPPPLGRVRSSFAPGDARTLRADGPGWSLVARTDDIAFILLDEEPGEVLPVGRGPSLPGLLEALDKMAVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZM8</accession>
    <name>Q9KZM8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1404</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027768.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1404"/>
    <dbReference type="GeneID" id="1096830"/>
    <dbReference type="KEGG" id="sco:SCO1404"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1414"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011855_0_0_11"/>
    <dbReference type="OMA" id="DCEACEI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1001" mass="108260" checksum="6F4165C35DE7EF2F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZV2</accession>
    <name>Q9KZV2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transport system transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4149</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628326.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029466.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4149"/>
    <dbReference type="GeneID" id="1099589"/>
    <dbReference type="KEGG" id="sco:SCO4149"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4213"/>
    <dbReference type="eggNOG" id="ENOG5033SX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041668_0_0_11"/>
    <dbReference type="OMA" id="GRPAAWH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="509" mass="53222" checksum="B735F91ABE431D29" modified="2000-10-01" version="1">MSAVLTEEAVPARTPAQDGPDHGTRAVLALARFEARRLLLSIPVLIAFAAYVAWIVWRTRTSWDGSPALQDADRATQSMPMLVGLAVLLCAARAVLRSERHGTEHHFSVLVLQPWRRTAAHALSVVPAALLTTLCVAGQFTWEALKPGAIGHASPAELAVGPLTVLVFGALGVLLGRLVRSAIAAPLLVVVLLFVFVLGTGPSEGSGLSWLAPVVSVTGPDTLPSDLLGRPAAWHALYLAGAALSVAFLAMAVSGGRGILVRVGLALSLAGAVTGGVLQAGGVTPSPELTAARERASVRPELTCSEHGRSRYCAFPEWAPRTGTWAAVVDHVQSLSGGSAHDRPLVVRQRIDARYGLGTDTALPASTEPHRVTVGTAWGGNRVPEFSSAVAAVLVAGTEAAGSELCDGRMVTVMWLSLSWQDDPMDALRRVRLDDSVTGSAIVLSPTNPLSMTEGQTDVVRRLLEDPPTGTGARVKEHWAELTAPGVPTARVAELLGVAGPEKADSCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0K1</accession>
    <name>Q9L0K1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO4664</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628824.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029797.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4664"/>
    <dbReference type="GeneID" id="1100105"/>
    <dbReference type="KEGG" id="sco:SCO4664"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4736"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0K1"/>
    <dbReference type="OMA" id="LAPAWFT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="602"/>
        </location>
    </feature>
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        <location>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="301"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="611" mass="61744" checksum="8F959720773AEDF9" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0T3</accession>
    <name>Q9L0T3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4511</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628675.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4511"/>
    <dbReference type="GeneID" id="1099951"/>
    <dbReference type="KEGG" id="sco:SCO4511"/>
    <dbReference type="HOGENOM" id="CLU_1969321_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="14428" checksum="419133939415717F" modified="2000-10-01" version="1">MIWKPGPGETLLARAPVTFATGAAMRVRGRRWFRDEERNDIQGELDGWPAGPVHRARSTGVGAVWAALRISGLAVGALIVAALPTGTAVGTASAPRTTGNRATNSRTSPSCGPRPAPSLAPCPGGWTRPAPTRDALGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0U6</accession>
    <name>Q9L0U6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative proton transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4498</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628662.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974451.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4498"/>
    <dbReference type="GeneID" id="1099938"/>
    <dbReference type="KEGG" id="sco:SCO4498"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4568"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019375_7_1_11"/>
    <dbReference type="InParanoid" id="Q9L0U6"/>
    <dbReference type="OMA" id="YFCTTII"/>
    <dbReference type="PhylomeDB" id="Q9L0U6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006835">
        <property type="term" value="P:dicarboxylic acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB77289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="440" mass="46458" checksum="52E4BCF787AAD989" modified="2000-10-01" version="1">MSVSSPSSFTKYLKVPFWAQILAGLVLGVLLGWLARSQDISWLVTTLEKVGDTFIGLLKLAVAPLVFFAILVSITNLRKVNNAARLASRTLLWFMITSLIAVAIGLVIGLVTNPGAGTGLTAADGAKPEHTGSWIDFLTGIVPTDVITPFTELNVLQIVFMAAVAGIAALQLGEKAQPILNLSESILELLQKALWWVIRLAPLGTVGLIGKAIATYGWDLIGKYATFTADIYVGCALVMFVVYPTLLATVAKASPLQFFKGAWPAIQLAFVSRSSVGTMPLTQKVTERLGVPKEYASFAVPFGATTKMDGCAAIYPAIAAIFVAQIFDIQLGVGDYLLIAFVSVVGSAATAGLTGATVMLTLTLSTLGLPMEGVGLLLAIDPILDMMRTATNVAGQALVPVIVSAREGLLDRKAYDEAHASPIDEPEREKQASEPVPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L158</accession>
    <name>Q9L158_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7457</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB76320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1102895"/>
    <dbReference type="KEGG" id="sco:SCO7457"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7568"/>
    <dbReference type="HOGENOM" id="CLU_1915840_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="13791" checksum="D5BBF6B3912D774B" modified="2000-10-01" version="1">MDRLLVDEPVEPARDVEAPAEGPAEPDALVETMDTEVRETGGIAARTGRAFHRVRAQVRGIGAAADGEEPARMHAGTVEAVRAGGAKAAEAAEAAVRRHFDDIRGRLSQHGRARAPVAPRSCEEGPGCPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L169</accession>
    <name>Q9L169_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB76309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7446"/>
    <dbReference type="GeneID" id="1102884"/>
    <dbReference type="KEGG" id="sco:SCO7446"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7556"/>
    <dbReference type="eggNOG" id="ENOG502ZEEN">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_22_2_11"/>
    <dbReference type="OMA" id="QISCARD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="15600" checksum="55D2D1E19BCDECA4" modified="2000-10-01" version="1">MDGAARTGDRLKDGSVKVSAEYPGMPGDIARGRELARRFLARVRAAQGAQVSERTVEVVQLVVSELLTNACKYAPGPSLVDLELAEDRVEVTVWDSAPVLPVPGPADPTRVGRHGLEIVMAVCESFEVHREPVGKRMRAAVGLAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L184</accession>
    <name>Q9L184_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7393</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631443.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031631.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7393"/>
    <dbReference type="GeneID" id="1102831"/>
    <dbReference type="KEGG" id="sco:SCO7393"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7503"/>
    <dbReference type="eggNOG" id="ENOG50337FI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061390_1_1_11"/>
    <dbReference type="OMA" id="NCQGTIG"/>
    <dbReference type="PhylomeDB" id="Q9L184"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176819" evidence="2">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="26450" checksum="D409F487CC4C636A" modified="2000-10-01" version="1">MRTGKVATAVATASVSVALLAGCGGDSGDEGKPFEGQSADDIAAKAVEATRQAKSVHVKGDTRLEDGSTVTIDVSVDQEKNCQGTIGAGETRADVRHTDATLYLRGDEQYWRTALEQQPDAARKMAPKLQDKWVRMPANDASTAGVCDKQGFIAAMDEDESERRGMKRGSTTEVNGEEALKLTKDASGGEKLTLYVATEGEPYILKTTTEGGENPGGVTFSEYGKTVDPQQPPADETVDMKELAGEQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1G8</accession>
    <name>Q9L1G8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2609</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626846.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976190.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2609"/>
    <dbReference type="GeneID" id="1098043"/>
    <dbReference type="KEGG" id="sco:SCO2609"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2655"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109835_0_0_11"/>
    <dbReference type="OMA" id="MRVNRIL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB75390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="22888" checksum="799DA099800BADFC" modified="2000-10-01" version="1">MRVNRILLSVALVVVALVIQVSVLARLHLPGAVPDLLLLTVLGLALVYGHVGGALVGFGAGLLADLAPPADHAAGRYALVLCVIGYLAGLARPDNGRLRSATGPMVVVVAAAVGTTLLYAGVGALVGDTAARHVGLPSLLFTAALYDLLLAPFVVPGIMALARRAEHDPLADTNSAAQSPDISSGWLSSGTGLRIGRQRNALRVKTARARVARAGRIKGVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCW1</accession>
    <name>Q9RCW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0850</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB65631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978009.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0850"/>
    <dbReference type="GeneID" id="1096273"/>
    <dbReference type="KEGG" id="sco:SCO0850"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.842"/>
    <dbReference type="eggNOG" id="ENOG5032S5B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119494_0_0_11"/>
    <dbReference type="OMA" id="AKDVWLV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="14733" checksum="3D5CFDCDF0DB0DE0" modified="2000-05-01" version="1">MRLPIELRHVAPRLATGAFILNSGLAKRGADEQTAAMMHGMAKNTYPFLGRLRPATFLRLLSAGEITLGAALLLPVVPTAVAGIGLTAFSAGLVGLYLRTPGMREEGSLRPTQDGTALAKDTWMLGIGIGFVVDGATSRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD38</accession>
    <name>Q9RD38_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO0871</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625171.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027406.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0871"/>
    <dbReference type="GeneID" id="1096294"/>
    <dbReference type="KEGG" id="sco:SCO0871"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.862"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_11"/>
    <dbReference type="InParanoid" id="Q9RD38"/>
    <dbReference type="OMA" id="PAAYMSK"/>
    <dbReference type="PhylomeDB" id="Q9RD38"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="297"/>
            <end position="515"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB62662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="531" mass="57958" checksum="3EF4C6C331000C73" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD57</accession>
    <name>Q9RD57_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="1096048"/>
    <dbReference type="KEGG" id="sco:SCO0625"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.607"/>
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    <dbReference type="OMA" id="GAPMYIN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
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        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="413"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB62754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="426" mass="44035" checksum="34AAC280A49C6037" modified="2000-05-01" version="1">MGVVILLVMAAGVAAMLTRKLPTAFALVLLAVVIAFLSGAPLTGKNSVLDTVLQEGAPALAATMVAIILGSWLGKLLDETGIAGTLVRKIVEFGGDRPTVVALGVLAVSALVGTVTGSAPAAMLAGIIGIPAMVAVGVPKVTAAGTVLMGIAVGVPFELPVWQFFSTALDLPVDTVRGFMVKLFPFALVAAVAYVVIENRRRGTEHAWSLKSVSARPAPRRERLGDAPWYALLAPVIPLVLALGLDVAIIPSMLAGVLYALVTTTRPGEMNKRLLRTLYGGFEVAAPPLALFVAIGILLAAVKLPGAVDALEPLMKAVSPQNPVLFVIVFTVLVPLCLYRGPLNVFGLGAGIAGVLIATGIYPAVAVLGMATSYNQVFGVADPTSTQTVWAAQYAGVSPQQVMVRTLPYVWLVALGGMCVTAALYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDF0</accession>
    <name>Q9RDF0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2541</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAB66219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626779.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028416.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2541"/>
    <dbReference type="GeneID" id="1097975"/>
    <dbReference type="KEGG" id="sco:SCO2541"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2586"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDF0"/>
    <dbReference type="OMA" id="VYYFSMW"/>
    <dbReference type="PhylomeDB" id="Q9RDF0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031224">
        <property type="term" value="C:intrinsic component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="17"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB66219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="456" mass="48941" checksum="20EB7C6C5ED0B5FA" modified="2000-05-01" version="1">MHSPAVQSAVRKIFRRVVPLFFVMFVANYMDRVNLGFAQDELRADVGLSAAAFGLGAGIFFIAYAIFEVPSNMLMERFGAKVWLTRIMISWGVVATAMAFVDSVEMFYALRFLLGVAEAGFFPAVIYYFSRWLPDSHRGRATSIFLMGSGTATVIVGPVSGALMELHGIWGHAGWQWMFFIEGVFSVVYRFLDSGVEQATWLTDEEKSGLVAAIDAEQDERDARRGGKAARVSRWKLLADPQMLLFLWIYFAINVALYAVTFWLPSIVDDIGGVSDFQVGLLTAVPWLCALAALFVSGRVSDRIGRRRPVLVVLLLLGGCGTLLAVFVSPWVGLGALCLAAMGFKPASPVFWTIPQSYLDARAAAPGIALINSIGNLGGFVAPTAFGIIEDTTGSTKGGLVGLTVVGFLAALSVLLVRGGGRNDRVRTRPAKAVAAPAPETTPGAARTAQPGPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDH3</accession>
    <name>Q9RDH3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626985.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2754"/>
    <dbReference type="GeneID" id="1098188"/>
    <dbReference type="KEGG" id="sco:SCO2754"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2810"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_6_3_11"/>
    <dbReference type="InParanoid" id="Q9RDH3"/>
    <dbReference type="OMA" id="WEYEKRW"/>
    <dbReference type="PhylomeDB" id="Q9RDH3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="268" mass="28321" checksum="B0FF1A2FC6C5EBBD" modified="2000-05-01" version="1">MGMKLAFSTLGVPGLPLTDVLGLATTHGYHGVELRAHPEEPVHPGLGPDERAAVAAEFRAAGVEPLGLAGYARVAAPGDDEPVLAEIRGLLDLARDLGAPYVRVFPGGGTEQSAEEADATAARRLGTAAEYAAERGVSILLETHDSHRTGADAMRVLGPVGHLRAGALWDVMHTWLGGEQPSETYAALAPHLGYVQVKDIASAEDTTPLALGAGVLPLTEVVDVLSRHGWDGWLCWEYEKRWYEAAAPLPELLGTGREHLARLLTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDI2</accession>
    <name>Q9RDI2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable LacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2745</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626976.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976055.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2745"/>
    <dbReference type="GeneID" id="1098179"/>
    <dbReference type="KEGG" id="sco:SCO2745"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2801"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RDI2"/>
    <dbReference type="OMA" id="MVFVDRW"/>
    <dbReference type="PhylomeDB" id="Q9RDI2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB66284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="347" mass="36847" checksum="78CC5D4C099AC008" modified="2000-05-01" version="1">MASIKDVAAEAGVSVATVSRALNGHPSVSAAARARVLAAVETLGYRPNALARSLRTDQTRTLGLVISDVMNPYFTELARSVEEEARALGYSVIIGNADERPDLQDHHVTTLLDRRIDGLLVSPTDGGSPRMLDAARAGTPMVFVDRWIPGVNVPVVRSDGRAAVRDLVAHLHGLGHRRLAIIAGPAATTTGRERVDAFREALGAYGLPLPDAYIGQGDFQAGSGRRVTEGFLDLPEPPEVVFAADNLMALGALDAVRARGLRVPEDVGLAAFDDIPWFVHTDPPVTAIAQPTRELGRAAVRALVERIAGRAGESVTLPARLVVRRSCGEPPSEPHPPSPSPVRRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI28</accession>
    <name>Q9RI28_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37049">
        <property type="entry name" value="T37049"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624553.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026936.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0220"/>
    <dbReference type="GeneID" id="1095644"/>
    <dbReference type="KEGG" id="sco:SCO0220"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.194"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133309_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RI28"/>
    <dbReference type="OMA" id="RPFYWDV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="16027" checksum="88B694CDDD270B32" modified="2000-05-01" version="1">MPSTTDSATVLTGMYAAEAEYLAAGGPGEASFDLLAPFFAPDVELHQADALPYGGTWRGHQGMTQFFLMMGEAWESFDMVEQEFLATGETAVVLTQVRARARATGRELSFPILQAITVKDGRITEVRPFYWDTRAIAEVCAVPTPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI45</accession>
    <name>Q9RI45_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane protein SCJ12.13c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0201</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37032">
        <property type="entry name" value="T37032"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624536.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978665.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0201"/>
    <dbReference type="GeneID" id="1095625"/>
    <dbReference type="KEGG" id="sco:SCO0201"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.173"/>
    <dbReference type="eggNOG" id="ENOG502ZZP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114557_0_0_11"/>
    <dbReference type="OMA" id="MGFVFLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB53425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="23359" checksum="ACECDE7D90A17B3F" modified="2000-05-01" version="1">MSGTNRILSEGVTVMAMHQSTHRGSGFHLPSSRRNGAVSVPGAADSVEAGALTARAFVFASARVLMGFVFLWAFLDKTFGFGYATASGKGWIDGGSPTEGFLGHVAVGPMESTFHSWAGAAWADWLFMLGLLGVGLALTAGVALRPAAVAGTVMMALMWAAEWPPAKHLSDGSASMSTNPFADYHVLYAVLLIALAAVSAGDALGLGRLWARLPIVRDHAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI70</accession>
    <name>Q9RI70_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative aminoglycoside nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0107</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37007">
        <property type="entry name" value="T37007"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0107"/>
    <dbReference type="GeneID" id="1095532"/>
    <dbReference type="KEGG" id="sco:SCO0107"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112803_1_0_11"/>
    <dbReference type="OMA" id="GGWGIDA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="20294" checksum="B08AEFD1F4B12C31" modified="2000-05-01" version="1">MRCRSDLYLRTVSHYAMSAEDALALLERLHAHGVDACVGGGWSVDALLGKQTRDHSDLDLWVPAVHLDPLFVAFGEAGVDRIFPWPGDRPWNFVLHDGVGLRVDLHLYEALADGSLHYGSVVDGAAFPAEALAGHGFIAGTAVRCESAEWAVRSHTGYPARDVDRHDVPLLCRKFEIPLPESFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI90</accession>
    <name>Q9RI90_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA_LIGASE_A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0085</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36985">
        <property type="entry name" value="T36985"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624433.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026836.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0085"/>
    <dbReference type="GeneID" id="1095513"/>
    <dbReference type="KEGG" id="sco:SCO0085"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634456_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006266">
        <property type="term" value="P:DNA ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="18254" checksum="D489972076969DD0" modified="2000-05-01" version="1">MNGELVVWESGRLAFERLQQRLARRRGAGALAAARACPAHLVVFGLMRQGSTDLPPWPCSRRRTALEELFAETRMTAPLTLCPSTADPDTARQWLTWTSTGQEGLVFKPLRAPYRAGARARGKYKICITEDRRRRSRHRPRHRGGGAGQSGVRLVYRSRSAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ15</accession>
    <name>Q9RJ15_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO1853</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626121.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028010.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1853"/>
    <dbReference type="GeneID" id="1097287"/>
    <dbReference type="KEGG" id="sco:SCO1853"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1877"/>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076014_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RJ15"/>
    <dbReference type="OMA" id="MEYPVTT"/>
    <dbReference type="PhylomeDB" id="Q9RJ15"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB59469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="25102" checksum="3F9F52363FBBAEA6" modified="2000-05-01" version="1">MSSTLIGVGVGPGDPELVTVKGVNALRGADVVVVPVMDTGERGRAEATVLHYVGAEKIMRVVFALNERTDRARREAAWDAAGERVAGLLREHAAVAFATIGDPNVYSTFTYLAQTVGALVPGTVVQTVPGITAMQDLAARSGAVLTEGTEPLTLVPVTAGSAVLKEALHGPGTVVAYKFGRQAAEVAEALRESGRLDDAVWGSALGLPEESVRPAGELDGAPLPYLSTLIAPARREGGRGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ30</accession>
    <name>Q9RJ30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1838</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626106.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028003.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1838"/>
    <dbReference type="GeneID" id="1097272"/>
    <dbReference type="KEGG" id="sco:SCO1838"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1860"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ30"/>
    <dbReference type="OMA" id="QEAFTWW"/>
    <dbReference type="PhylomeDB" id="Q9RJ30"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="28146" checksum="1FFB10951856878A" modified="2000-05-01" version="1">MASPAHDPGPALDQDGVRLTVDDAIATVTLTNPAKRNAQSPALWRALAEAGRRLPGSVRAVVLRAEGKSFSAGLDRQAFTPEGFDGEPSFIDLARGADAELDATIAEYQEAFTWWRRSDLVSVAAVQGHAIGAGFQLALACDLRVVADDVQFAMRETSLGLVPDLTGTHPLVSLVGYARALEICATGRFVAAEEAVSTGLANLAVPADQLDPAVHDLVSAILAAPRDAVVETKALLQGAQTRDYEAQRTAERAAQGRRLRDLAGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ77</accession>
    <name>Q9RJ77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1624</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625899.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027890.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1624"/>
    <dbReference type="GeneID" id="1097055"/>
    <dbReference type="KEGG" id="sco:SCO1624"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1639"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_4_11"/>
    <dbReference type="InParanoid" id="Q9RJ77"/>
    <dbReference type="OMA" id="HDMHLHA"/>
    <dbReference type="PhylomeDB" id="Q9RJ77"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:peptide-serine-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017198">
        <property type="term" value="P:N-terminal peptidyl-serine acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="21706" checksum="EC6B0207B37D640A" modified="2000-05-01" version="1">MPSMPFLTRPVLAAGTFSGAPQPTLPTGDGLVLRPWRTEDAPAVHVAFQDPVMHQWHARAADSEEEVRGWITEWQGAWERERGVQWAVADAADDRLLGRVALREWVLGDGVAEVAYWTTADARGRGVAARATRTLAHWALDEIGFQRLELLHAVANDASCRVAQKTGFALEGTKRKAVLHPDGWHDMHLHARVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJC9</accession>
    <name>Q9RJC9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0764</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625067.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027339.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0764"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1096187"/>
    <dbReference type="KEGG" id="sco:SCO0764"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.755"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018974_0_0_11"/>
    <dbReference type="OMA" id="KFREGCV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="378"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="535" mass="56382" checksum="5B67400BF5D7B5FB" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKA9</accession>
    <name>Q9RKA9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3179</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627394.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028812.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3179"/>
    <dbReference type="GeneID" id="1098613"/>
    <dbReference type="KEGG" id="sco:SCO3179"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3239"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_4_1_11"/>
    <dbReference type="InParanoid" id="Q9RKA9"/>
    <dbReference type="OMA" id="CGVAGQT"/>
    <dbReference type="PhylomeDB" id="Q9RKA9"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="18"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="17706" checksum="AF8408CD6BF9460B" modified="2000-05-01" version="1">MTPDAGVGGALLGPYAALVVTASNRAAAGVYEDRGGPLIAEGLRRFGFAVDGPQVVPDGDPVRAALRAGVEAGFDVIVTTGGTGISPTDRTPEATRAVIDREVPGIAEAIRAYGRDKVPAAALSRGLAGVAGGTLIVNLPGSSGGVKDGLAVLEPLLKHAVDQIRGGDHPRPASGGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKW7</accession>
    <name>Q9RKW7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1408</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625690.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027772.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1408"/>
    <dbReference type="GeneID" id="1096834"/>
    <dbReference type="KEGG" id="sco:SCO1408"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1418"/>
    <dbReference type="eggNOG" id="ENOG502ZKIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072537_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKW7"/>
    <dbReference type="OMA" id="MAFPRPE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="293" mass="31054" checksum="696ABAF8E9F31ED8" modified="2000-05-01" version="1">MTEYVDRSEPEAGAAPATAAVTPADAADAARLVAFGLQPKLLPARDQEYADLLRRYREDPPFARLADAVAAGLGLIVLEVSPRAGMAVSAAEDSVFAVRMGDYARRAATDSGDRFLHGLAHLAVAAMAYPRPEDLADDGYIGRVTVNGVDAFVRQACRRLEERAEQQGENTDPATDAPGLEAAWRIWVRRSATGATKDARRLPGSTTGIVGKAAGFLTESGFLQRTGDDHGGTYRTTARYQLQVRDMAGSAALTELLDLGVVPVTDGTATLLPAEETDDLELVADAGLPFHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKY6</accession>
    <name>Q9RKY6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1427</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027781.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096853"/>
    <dbReference type="KEGG" id="sco:SCO1427"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1437"/>
    <dbReference type="eggNOG" id="ENOG5031WDT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2411941_0_0_11"/>
    <dbReference type="OMA" id="LMRTWAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="105" mass="11366" checksum="00D277F31DD41FB3" modified="2000-05-01" version="1">MTPTYSSTGSRRRVFVPVPAGPVPPAPQIPDPPIYRDLMRTWADGGRTLPGRHDPEWVRLAEPPRGLGDFFATGDFFTTGDFRGGGDFAVAADLSAPRDPRGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S218</accession>
    <name>Q9S218_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1782</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36885">
        <property type="entry name" value="T36885"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626053.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027974.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1782"/>
    <dbReference type="TCDB" id="1.C.109.1.2">
        <property type="family name" value="the bacterial hemolysin a (tlya) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1097213"/>
    <dbReference type="KEGG" id="sco:SCO1782"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1801"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S218"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="PhylomeDB" id="Q9S218"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="28455" checksum="87D3A01DB831BEDF" modified="2000-05-01" version="1">MAGVARRRLDAELVRRKLARSREHASQLIAAGRVTVGKTVATKPATQVETAAAIVVTADDNDPDYVSRGGHKLAGALAAFVPHGLVVEGRRALDAGASTGGFTDVLLRAGAAHVVAVDVGYGQLAWSLRQDERVTVKDRTNVRELTPEAIDGEPVDLVVGDLSFIPLALVLPALVRCTRPGADLVMMVKPQFEVGKERLGSGGVVRSAQLRAEAVRGVARKAWELGLGVKGVTASPLPGPSGNVEYFLWLRAGAGELDPADVDRAVAEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S264</accession>
    <name>Q9S264_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1688</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB46786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36789">
        <property type="entry name" value="T36789"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625962.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027919.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1688"/>
    <dbReference type="GeneID" id="1097119"/>
    <dbReference type="KEGG" id="sco:SCO1688"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1705"/>
    <dbReference type="eggNOG" id="ENOG5031J0W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150487_0_0_11"/>
    <dbReference type="OMA" id="VCALCCA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB46786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="113" mass="11471" checksum="5536F191AB2076BF" modified="2000-05-01" version="1">MNGADAAPDAAPPDRDPGLQPERTRLAWRRTTLSGTVVAVLAAKAALHGGATPLSVLAVSLCCVLWLAFLLIAHGRIRTLASANRPPALPPPHAAAAALCTLALAVCGALLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2H8</accession>
    <name>Q9S2H8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2903</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36126">
        <property type="entry name" value="T36126"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975907.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2903"/>
    <dbReference type="GeneID" id="1098336"/>
    <dbReference type="KEGG" id="sco:SCO2903"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2962"/>
    <dbReference type="eggNOG" id="ENOG50340A2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127710_0_0_11"/>
    <dbReference type="OMA" id="GLTTGCD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176972" evidence="1">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="134" mass="14183" checksum="CB164CC6864621E3" modified="2000-05-01" version="1">MAASRHRRLRRTVTAVATVATIALTAGLTTGCDAVDKALDCVRTADAIADSVTELQQAVENADDPTQWEESLNSIDKNLDRIGDQTDNTDVNKAVDDLGKAVDNVRTSVENGDETPDLSPVTDAAGELTKVCTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2T7</accession>
    <name>HIS6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber>4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>ImGP synthase subunit HisF</fullName>
            <shortName>IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hisF</name>
        <name type="ordered locus">SCO2048</name>
        <name type="ORF">SC4G6.17c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35077">
        <property type="entry name" value="T35077"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626308.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976768.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2T7"/>
    <dbReference type="SMR" id="Q9S2T7"/>
    <dbReference type="STRING" id="100226.SCO2048"/>
    <dbReference type="GeneID" id="1097482"/>
    <dbReference type="KEGG" id="sco:SCO2048"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2079"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_11"/>
    <dbReference type="InParanoid" id="Q9S2T7"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="PhylomeDB" id="Q9S2T7"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000142243" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="251" mass="26557" checksum="8CDE0C1F2924A3D3" modified="2000-05-01" version="1">MTLAVRVIPCLDVDNGRVVKGVNFQNLRDAGDPVEMAKVYDAEGADELTFLDITASSGNRETTYDVVRRTAEQVFIPLTVGGGVRTAEDVDKLLRAGADKVGVNTAAIARPDLIREIAERFGRQVLVLSVDARRTEAGTFEVTTHGGRRGTGIDAVEWAHRAAELGAGEILLNSMDADGTKDGYDLEMLAAVRKHVSVPVIASGGAGSLAHFAPAVEAGADAVLAASVFHFGDLRIGEVKTTLREAGHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7V6</accession>
    <name>Q9X7V6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6761</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35401">
        <property type="entry name" value="T35401"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630833.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031163.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6761"/>
    <dbReference type="GeneID" id="1102200"/>
    <dbReference type="KEGG" id="sco:SCO6761"/>
    <dbReference type="HOGENOM" id="CLU_3085023_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045960">
        <property type="entry name" value="DUF6380"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19907">
        <property type="entry name" value="DUF6380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB39694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="52" mass="5717" checksum="71243D0CBF624140" modified="1999-11-01" version="1">MDTPGTLDTRDPYKTGGGQWRATLRWRSASLTETVSRTPFKHRGGRTGKGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X803</accession>
    <name>Q9X803_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2144</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35526">
        <property type="entry name" value="T35526"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626400.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028163.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2144"/>
    <dbReference type="GeneID" id="1097578"/>
    <dbReference type="KEGG" id="sco:SCO2144"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2179"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_10_0_11"/>
    <dbReference type="InParanoid" id="Q9X803"/>
    <dbReference type="OMA" id="NFSICLM"/>
    <dbReference type="PhylomeDB" id="Q9X803"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177009" evidence="6">
        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB39871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="469" mass="47730" checksum="0AC85936C05AA5B7" modified="1999-11-01" version="1">MNLRLAAALCAALSLCAVLAVPANFPALGGDARLTLAVFALATCAWIGTPIDDTYIALGAGLALTATGVISSDTLFGTLGEDTVWLLICAFVLAAAVARTGLAGRAAAFLVGGARTVRQLVHLTTAALVVTAFAMPATSGRAALALPVFLALAKVLADRKRLVVMLALLFPTVILLSAVATLIGAGAHLITVSVLWEATGDRIGFTQWLLLGLPLAVASSHLAAETVLLTTTRRADRAGPVRITAEEIQRHSESPVTGPWTQAEKRCALLLATVVALWCSEPLHRVSPAVVALIGAVVASSPALGTVRLKDALKTVPWSLLLFMAATMAMGVALADSGAAGWLVSGLPADVAPAVFLGVVVAVSTAAHLVLQSRSARSSVLVPLVIAAAVGAGVNPVAAALASTAAAGFCHTLPASAKPVTLFSDVPGVPTYTPRDLLRLSAVLAPLTALLVLFFAAAVWPLLGVPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8B0</accession>
    <name>Q9X8B0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative large ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3534</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36175">
        <property type="entry name" value="T36175"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627734.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029070.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3534"/>
    <dbReference type="GeneID" id="1098970"/>
    <dbReference type="KEGG" id="sco:SCO3534"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3591"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017355_0_0_11"/>
    <dbReference type="OMA" id="CCPACEA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="840" mass="90383" checksum="664490BD9E022F08" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8P7</accession>
    <name>Q9X8P7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36520">
        <property type="entry name" value="T36520"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627824.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029127.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3630"/>
    <dbReference type="GeneID" id="1099066"/>
    <dbReference type="KEGG" id="sco:SCO3630"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3689"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918032_0_0_11"/>
    <dbReference type="OMA" id="PWLRTCQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="30585" checksum="BAD3DEEDA3B3A77A" modified="1999-11-01" version="1">MAEVATSASSSANSSARSVSLLVVVDPVARRLDGESVRIAKDVLSAGASHTKVCLPDDPEEFARALGRRGSRRPVVIGDDSALLRAVALLHRRRELAGCALSVVPVGSALGLARSLGLPTGAVAAARAVLDGAERRLDLLVDDSDGVVLGTVGIPPVPAPVPVRAEAGSGPQGAASVRPWLRTCQSLVRTLASSRTARTAVAPGTPGPARLRVEVDGVTLVDLDQPVEGVSVTPGAAGVAVVEVRPLSVGAQASPLTASGRTVTVSGAHFRYRADAVVSGPVGTRTWVAREGAWGLTLPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA42</accession>
    <name>Q9XA42_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3571</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2007-05" db="PDB data bank">
            <title>The crystal structure of the N-terminal domain of a transcriptional regulator from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Xu X."/>
                <person name="Zheng H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A.M."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-145</scope>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36556">
        <property type="entry name" value="T36556"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627768.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975365.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDB" id="2PQQ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C/D=1-145"/>
    </dbReference>
    <dbReference type="PDBsum" id="2PQQ"/>
    <dbReference type="SMR" id="Q9XA42"/>
    <dbReference type="STRING" id="100226.SCO3571"/>
    <dbReference type="DNASU" id="1099007"/>
    <dbReference type="GeneID" id="1099007"/>
    <dbReference type="KEGG" id="sco:SCO3571"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3627"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_11"/>
    <dbReference type="InParanoid" id="Q9XA42"/>
    <dbReference type="OMA" id="VLCRDFG"/>
    <dbReference type="PhylomeDB" id="Q9XA42"/>
    <dbReference type="EvolutionaryTrace" id="Q9XA42"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2PQQ"/>
        </source>
    </evidence>
    <sequence length="224" mass="24675" checksum="D987F8AD782041A3" modified="1999-11-01" version="1">MDDVLRRNPLFAALDDEQSAELRASMSEVTLARGDTLFHEGDPGDRLYVVTEGKVKLHRTSPDGRENMLAVVGPSELIGELSLFDPGPRTATGTALTEVKLLALGHGDLQPWLNVRPEVATALLRAVARRLRKTNDAMSDLVFSDVPGRVARALLDLSRRFGVQSEEGIHVVHDLTQEELAQLVGASRETVNKALADFAQRGWLRLEARAVILLDVERLAKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA53</accession>
    <name>Q9XA53_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3825</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36506">
        <property type="entry name" value="T36506"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628014.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975109.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3825"/>
    <dbReference type="GeneID" id="1099261"/>
    <dbReference type="KEGG" id="sco:SCO3825"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3894"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="InParanoid" id="Q9XA53"/>
    <dbReference type="OMA" id="VMITMYT"/>
    <dbReference type="PhylomeDB" id="Q9XA53"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
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    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="42"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB46948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="31046" checksum="56C1924DBB81E6D3" modified="1999-11-01" version="1">MSTATSSENKDLSPVSTESLAALLVTRERPPRPSALSTSLTFGWRAILKIKHVPEQLFDVTAFPIMNLLMFTYLFGGALAGSPRDYIQFVLPGILVMSVVMITMYTGVSVNIDIEKGVFDRIRSLPIWRPSAMVGYLLGDALRYTIASVVMLSVGLLLGYRPDGGFVGVVAGIALLLLFSFAFSWIWTMFGLMLRTEKSVMSVSMMVIFPLTFLSNVFVDPKTMPGWLQAFVNNSPITHLASAVRGLMAGDWPGAEIAWTLGWAALFLLVFGPVTMRLYNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC7</accession>
    <name>Q9XAC7_STRCO</name>
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        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO1929</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36001">
        <property type="entry name" value="T36001"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626194.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976890.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1929"/>
    <dbReference type="GeneID" id="1097363"/>
    <dbReference type="KEGG" id="sco:SCO1929"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1955"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_4_1_11"/>
    <dbReference type="InParanoid" id="Q9XAC7"/>
    <dbReference type="OMA" id="LGWSPHG"/>
    <dbReference type="PhylomeDB" id="Q9XAC7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="41"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB50754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="27506" checksum="31CA5346A5DD9B82" modified="1999-11-01" version="1">MTTTTGTPGNTGTPGAAGTYAPRPGAAPLGRMIAAQAVLETKMLLRNGEQLLLTVIIPTLLLVLFSSVDIIDTGAGEAVDFLAPGILALAVMSTAFTGQAIATGFERRYGVLKRLAASPLPRWALMTAKTASVLVTEVLQIVLLTVIALALGWSPHGNPAAVLLLLVLGTAAFSGLGLLMAGTLKAEATLAAANLVFLLLLVGGGVIVPLDRFPDAAQDVLGLLPISALSDGLRDVLQHGAAMPWGDLGILAGWAVAGLAAAGKFFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAL6</accession>
    <name>Q9XAL6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB45588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35032">
        <property type="entry name" value="T35032"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630787.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031127.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9XAL6"/>
    <dbReference type="GeneID" id="1102153"/>
    <dbReference type="KEGG" id="sco:SCO6714"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6821"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069623_2_0_11"/>
    <dbReference type="InParanoid" id="Q9XAL6"/>
    <dbReference type="OMA" id="WLPYFEV"/>
    <dbReference type="PhylomeDB" id="Q9XAL6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="27276" checksum="F9A9F43F8E4976F9" modified="1999-11-01" version="1">MLTTRFVTGAPNWLDVGTSDLDGATSFYGGLFGWRFRSAGPEAGGYAFFELDGRIVAGGMGTTEEQGPPSWTVYFQAPDARAAAQASGEAHGGVLVQPMDVMDQGTMAILADRAGLPFGIWQPGQRAGLDVTGESGALCWVELHTADIAAAAAYYRAVLGLETSGVSFPGGSYTCVNPAGEGEDAMFGGLVPLAEDPADTDADAGWLPYFAVDDADTAVARTTELGGTVRMPATDIEGVGRVARLADPYGARFAVLRPAPRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z571</accession>
    <name>Q9Z571_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-05" db="PDB data bank">
            <title>Structural and Enzymatic Characterization of a Thermostable PQQ-dependent Soluble Aldose Sugar Dehydrogenase.</title>
            <authorList>
                <person name="Southall S.M."/>
                <person name="Doel J.J."/>
                <person name="Oubrie A."/>
                <person name="Richardson D.J."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 104-447 IN COMPLEX WITH ARABINOSE AND CALCIUM</scope>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35824">
        <property type="entry name" value="T35824"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629643.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030285.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="PDB" id="3DAS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A=104-447"/>
    </dbReference>
    <dbReference type="PDBsum" id="3DAS"/>
    <dbReference type="SMR" id="Q9Z571"/>
    <dbReference type="STRING" id="100226.SCO5508"/>
    <dbReference type="GeneID" id="1100948"/>
    <dbReference type="KEGG" id="sco:SCO5508"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5593"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z571"/>
    <dbReference type="OMA" id="RLWRIPL"/>
    <dbReference type="PhylomeDB" id="Q9Z571"/>
    <dbReference type="EvolutionaryTrace" id="Q9Z571"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="131"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Arabinose</name>
            <dbReference type="ChEBI" id="CHEBI:46987"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Arabinose</name>
            <dbReference type="ChEBI" id="CHEBI:46987"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Arabinose</name>
            <dbReference type="ChEBI" id="CHEBI:46987"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Arabinose</name>
            <dbReference type="ChEBI" id="CHEBI:46987"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Arabinose</name>
            <dbReference type="ChEBI" id="CHEBI:46987"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB37584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3DAS"/>
        </source>
    </evidence>
    <sequence length="447" mass="46718" checksum="01D72AC1DC201A5B" modified="1999-05-01" version="1">MRPAAPGRPESGAGVRGSRLAVRGSRFAARGSGFGDREPGERLRCMTGRTRRVEGTKIVQRRAVPAVLTAALLLTAGCSSGSSDGADPSKTDRGASPTSTAAQSSPAGSPTEQAPPAKGSVKVLRTVATGLNSPWGLAPLPGGDLLVSSRDEATITRVDAKTGRKTELGEVPGVSPSGEGGLLGIALSPDYASDHMVYAYFTSASDNRIVRMLYDEKKPSGEQLGAPDTVFRGIPKGVIHNGGRIAFGPDKMLYAGTGESGDTGLSQDRKSLGGKILRMTPDGEPAPGNPFPGSPVYSYGHRNVQGLAWDDKQRLFASEFGQDTWDELNAIKPGDNYGWPEAEGKGGGSGFHDPVAQWSTDEASPSGIAYAEGSVWMAGLRGERLWRIPLKGTAAAADPQAFLEGEYGRLRTVAPAGGDKLWLVTSNTDGRGDAKGGDDRILELEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBI6</accession>
    <name>Q9ZBI6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyl-peptide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6488</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35975">
        <property type="entry name" value="T35975"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630571.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972490.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6488"/>
    <dbReference type="ESTHER" id="strco-SCO6488">
        <property type="family name" value="PMH_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.072"/>
    <dbReference type="GeneID" id="1101927"/>
    <dbReference type="KEGG" id="sco:SCO6488"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6589"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012236_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBI6"/>
    <dbReference type="OMA" id="EVWCVLE"/>
    <dbReference type="PhylomeDB" id="Q9ZBI6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="436"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="655" mass="70834" checksum="91C0ECABFA8D3FB3" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ6</accession>
    <name>FPG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName>Fapy-DNA glycosylase</shortName>
            <ecNumber>3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName>AP lyase MutM</shortName>
            <ecNumber>4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mutM</name>
        <name type="synonym">fpg</name>
        <name type="ordered locus">SCO5573</name>
        <name type="ORF">SC7A1.17</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23"/>
    <dbReference type="EC" id="4.2.99.18"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35657">
        <property type="entry name" value="T35657"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629708.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973422.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBQ6"/>
    <dbReference type="SMR" id="Q9ZBQ6"/>
    <dbReference type="STRING" id="100226.SCO5573"/>
    <dbReference type="GeneID" id="1101014"/>
    <dbReference type="KEGG" id="sco:SCO5573"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5662"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ6"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="PhylomeDB" id="Q9ZBQ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000170867" description="Formamidopyrimidine-DNA glycosylase">
        <location>
            <begin position="2"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FPG-type">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="1">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="286" mass="32511" checksum="C98F08045A9F386B" modified="2007-01-23" version="3">MPELPEVEVVRRGLERWAAHRTVADVEVLHPRAVRRHVAGPDDFAHRLKDHRIGTPSRRGKYLWLPLEDTDQAVLAHLGMSGQLLVQPHETPAEKHLRIRVRFADALGTELRFVDQRTFGGLSLHDTSADGLPDVIAHIARDPLDPLFDDEAFHHALRRKRTTIKRALLDQSLISGVGNIYADEALWRARLHYERPTATLTRPRTTELLGHVRDVMNAALAVGGTSFDSLYVNVNGESGYFDRSLDAYGREGMPCRRCATPMRRRPWMNRSSYFCPKCQRPPRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBR8</accession>
    <name>Q9ZBR8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35645">
        <property type="entry name" value="T35645"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629696.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973433.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5561"/>
    <dbReference type="GeneID" id="1101002"/>
    <dbReference type="KEGG" id="sco:SCO5561"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5650"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBR8"/>
    <dbReference type="OMA" id="TCPVVHF"/>
    <dbReference type="PhylomeDB" id="Q9ZBR8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="8267" checksum="05371CD52A3602EF" modified="1999-05-01" version="1">MVQAYILIQTEVGKASTVAETISKLPGVIQAEDVTGPYDVIVRAQSDTVDELGRMVVAKVQQVDGITRTLTCPVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBV5</accession>
    <name>Q9ZBV5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6563</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35005">
        <property type="entry name" value="T35005"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630644.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972416.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6563"/>
    <dbReference type="GeneID" id="1102002"/>
    <dbReference type="KEGG" id="sco:SCO6563"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6667"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_11"/>
    <dbReference type="InParanoid" id="Q9ZBV5"/>
    <dbReference type="OMA" id="IGMASPM"/>
    <dbReference type="PhylomeDB" id="Q9ZBV5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA22367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="446" mass="47069" checksum="F638F01131F3C636" modified="1999-05-01" version="1">MSPPVAPPGWSRWLVPPAALSVHLSIGQAYAWSVFKPPLESALDLSGTQSALPFQLGIVMLGLSAAFGGTLVERHGPRWAMTVALICFSSGFLLSALGAAAGQYWLIVLGYGFVGGIGLGIGYISPVSTLIKWFPDRPGMATGIAIMGFGGGALIASPWSAQMLKSFGTDNSGIALAFLVHGLTYAVFMLLGVLLVRVPRPRERADGRPAPLEGVQVSARSAVRTPQFWLLWIVLCMNVTAGIGILEKAAPMITDFFSDTSTPVSVTAAAGFVALLSAANMAGRFGWSSASDLIGRKNIYRVYLGVGALMYTLIALFGDSSKPLFVLCALVVVSFYGGGFATAPAYLKDLFGTYQVGAIHGRLLTAWSLAGVLGPLIVNWIADHQEEAGRHGSALYGTSFLIMIGLLVVGFVANELVRPVHARHHQPATPTQQEGNDVTRPQPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O54112</accession>
    <name>O54112_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5916</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34588">
        <property type="entry name" value="T34588"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630034.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030531.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5916"/>
    <dbReference type="GeneID" id="1101358"/>
    <dbReference type="KEGG" id="sco:SCO5916"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6013"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101798_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA16453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="19355" checksum="F4AEB4D0951A60CF" modified="1998-06-01" version="1">MGCLRFSGCERALGRLSRDAVRSAPWGPQDDPVSDRWHLWKNLCDKALAEVRSHSACWTTANTPRPVGVHEQTTRERWHQLHDLLGKGVGLLECARRLNLSLNTVKRYPRTRDPEALRPVKQLFREVQEQGCTGSFTLLYRSTQGRAEGDRPVGGSRLDAHRIHHWNGDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O54189</accession>
    <name>CBIN_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalt transport protein CbiN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Energy-coupling factor transporter probable substrate-capture protein CbiN</fullName>
            <shortName evidence="1">ECF transporter S component CbiN</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbiN</name>
        <name type="ordered locus">SCO5960</name>
        <name type="ORF">SC7H1.30c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbiN family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35725">
        <property type="entry name" value="T35725"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030566.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54189"/>
    <dbReference type="STRING" id="100226.SCO5960"/>
    <dbReference type="GeneID" id="1101402"/>
    <dbReference type="KEGG" id="sco:SCO5960"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6057"/>
    <dbReference type="eggNOG" id="COG1930">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136197_2_0_11"/>
    <dbReference type="InParanoid" id="O54189"/>
    <dbReference type="OMA" id="TEIEPDY"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00330">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003705">
        <property type="entry name" value="CbiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38662">
        <property type="entry name" value="PTHR38662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02553">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01165">
        <property type="entry name" value="cbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0171">Cobalt transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000134699" description="Cobalt transport protein CbiN">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="118" mass="12271" checksum="54927C086E905C13" modified="1998-06-01" version="1">MSRNTRINALLLLAVAALAVLPLVLGLGDHKEEPFAGADAEAETAITEIEPDYEPWFSPLHEPPSGEVESALFALQAALGAGVLAYYFGLRRGRRQGEERASAASGAAAAPGDAPEGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O54569</accession>
    <name>YIDC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">yidC</name>
        <name type="ordered locus">SCO3883</name>
        <name type="ORF">STH24.05</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Bacteriol." volume="174" first="3220" last="3226">
            <title>Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome.</title>
            <authorList>
                <person name="Calcutt M.J."/>
                <person name="Schmidt F.J."/>
            </authorList>
            <dbReference type="PubMed" id="1577691"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Gene" volume="217" first="83" last="90">
            <title>Gene organization in the trxA/B-oriC region of the Streptomyces coelicolor chromosome and comparison with other eubacteria.</title>
            <authorList>
                <person name="Gal-Mor O."/>
                <person name="Borovok I."/>
                <person name="Av-Gay Y."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
            </authorList>
            <dbReference type="PubMed" id="9795152"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(98)00357-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF187159">
        <property type="protein sequence ID" value="AAF16008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF031590">
        <property type="protein sequence ID" value="AAC03487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36570">
        <property type="entry name" value="T36570"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628069.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029289.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54569"/>
    <dbReference type="SMR" id="O54569"/>
    <dbReference type="STRING" id="100226.SCO3883"/>
    <dbReference type="GeneID" id="1099319"/>
    <dbReference type="KEGG" id="sco:SCO3883"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3956"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_3_1_11"/>
    <dbReference type="InParanoid" id="O54569"/>
    <dbReference type="OMA" id="ERYKNDR"/>
    <dbReference type="PhylomeDB" id="O54569"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000124756" description="Membrane protein insertase YidC">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="431" mass="47373" checksum="6E6D2E04D3EC4D65" modified="1998-06-01" version="1">MDTIASLFSFITWPVSWVIVQFHTVYGAIFGPDTGWAWGLSIVSLVILIRICLIPLFVKQIKATRGMQTLQPEMKKIQERYKNDKQRQSEEMMKLYKETGTNPLSSCLPILAQSPFFFALYHVLNGIASGDTIGKINQPLLESAQKAHIFGAPLAAKFTDGASKVESLGASLTDVRVITAVMIVLMSASQFFTQRQLMTKNVDTSVKTPFMQQQKMLMYVFPVMFAVFGINFPVGVLVYWLTTNVWTMGQQMYVIRNNPTPGSKAQASYLERLHKSVTEHGRTRRRGEKAIVKAIVAKGRDRNEAERKFINGLNKAGLAAQADGNVVKNDAAVAVQSEDGSTVTTTAQPKRQQPKRQSKSQRQAKPAGETEPKTSLTKSDEPQDAEPAGKQDAKPAAGAKKPAQKSGGGGRSKAQSGQRKGPQRPKSPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O69868</accession>
    <name>O69868_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6038</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34718">
        <property type="entry name" value="T34718"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630149.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030611.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6038"/>
    <dbReference type="MEROPS" id="S54.027"/>
    <dbReference type="GeneID" id="1101479"/>
    <dbReference type="KEGG" id="sco:SCO6038"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6138"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_5_1_11"/>
    <dbReference type="InParanoid" id="O69868"/>
    <dbReference type="OMA" id="LWIGQQF"/>
    <dbReference type="PhylomeDB" id="O69868"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="213"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA19250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="383" mass="41319" checksum="7A194F6EA648F763" modified="1998-08-01" version="1">MGRPARGAQPVAHRLVQRHRPLHLRRQPPRLLTEAGDVLPGEDEGDLGLAVGQGVHRRSRCDPFVHRLFLTSSPRPAFPGPRAVERAYVHTDGGVQRGGPVHRRPGGQYCLVVIPVHDVNPARRTPWVTYALILANVLVFLFTPGMAGSASGDGSLAQMCDLQAFLDHWAAVPQELLQHRMPRLVPTGAVGVGPQGPGCVVAPPGYDKSPELSVLTAMFLHGGWLHLLGNMLFLWIFGNNVEDRMGHVPFLLFYGVCGYAATYGFALLDADSGAPLIGASGAIAGVLGAYLVLYPRARVWVLVPFLVFLPLRLPAWLVLGFWFGLQAVYSSGGAVSDAGTVAYVAHVVGFVVGMLIAWPLRRGTPRPPQPPGLLFGRRARPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O69870</accession>
    <name>O69870_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6040</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34720">
        <property type="entry name" value="T34720"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630151.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030613.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6040"/>
    <dbReference type="GeneID" id="1101481"/>
    <dbReference type="KEGG" id="sco:SCO6040"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6141"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_0_1_11"/>
    <dbReference type="InParanoid" id="O69870"/>
    <dbReference type="OMA" id="WDAFVTM"/>
    <dbReference type="PhylomeDB" id="O69870"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004159618" evidence="3">
        <location>
            <begin position="44"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="34165" checksum="F8228B1E0462A6F8" modified="1998-08-01" version="1">MMQARRQATGRTAAPRSVPPARALAGLLLVTALALTGCSASDAGSDAGGNAKAAAPQQGSQAAGSQADGTTGAAGEGGSDGAGASTPPKLAPAHIIRTVSLSVQVKDTPRALDAARTATENAGGYVGDESTTRDAEGHERTEVTLRVPVERYEDVLDDLEGAGKLLRRDAKAEDVTDQVVDVDSRVKSQRASVARVRELMDRATRLSDVVSLEGELSTRQAELEALLARQAALKDRTSLATITLSLSETPVKHEEKKEDEDPGFTDALAGGWDAFVAMLRWVAVVLGAVAPFAAMAALLALLWLRVVRPRLPRRPKGPRGAEPGARD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O86696</accession>
    <name>O86696_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO6650</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2008" name="Acta Crystallogr. F Struct. Biol. Commun." volume="64" first="875" last="879">
            <title>Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Spoonamore J.E."/>
                <person name="Roberts S.A."/>
                <person name="Heroux A."/>
                <person name="Bandarian V."/>
            </authorList>
            <dbReference type="PubMed" id="18931427"/>
            <dbReference type="DOI" id="10.1107/S1744309108027048"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 2-132</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35059">
        <property type="entry name" value="T35059"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630726.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031076.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="PDB" id="3D7J">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.45 A"/>
        <property type="chains" value="A/B/C/D/E/F=2-132"/>
    </dbReference>
    <dbReference type="PDBsum" id="3D7J"/>
    <dbReference type="SMR" id="O86696"/>
    <dbReference type="STRING" id="100226.SCO6650"/>
    <dbReference type="GeneID" id="1102089"/>
    <dbReference type="KEGG" id="sco:SCO6650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6755"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_3_11"/>
    <dbReference type="InParanoid" id="O86696"/>
    <dbReference type="OMA" id="ESHVAWA"/>
    <dbReference type="PhylomeDB" id="O86696"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="EvolutionaryTrace" id="O86696"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAA20561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="3D7J"/>
        </source>
    </evidence>
    <sequence length="132" mass="14401" checksum="06886D0BB55EFAF9" modified="1998-11-01" version="1">MFSITVRDHIMIAHSFRGDVFGPAQRLHGATFLVDATFRREQLDEDNIVVDIGLATQELGAVVGALNYRNLDNEPDFAGVNTSTEFLAKVIADRLAERVHKGALGEGARGLAGLTVTLHESHVAWASYERAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O86776</accession>
    <name>TRUA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="ordered locus">SCO4731</name>
        <name type="ORF">SC6G4.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35560">
        <property type="entry name" value="T35560"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628889.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974242.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86776"/>
    <dbReference type="SMR" id="O86776"/>
    <dbReference type="STRING" id="100226.SCO4731"/>
    <dbReference type="GeneID" id="1100172"/>
    <dbReference type="KEGG" id="sco:SCO4731"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4802"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_2_11"/>
    <dbReference type="InParanoid" id="O86776"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="PhylomeDB" id="O86776"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000057460" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="284" mass="31312" checksum="D2F10B0416F5ECE1" modified="1998-11-01" version="1">MSDEVEAGFVRVRLDLSYDGSEFSGWAKQAGGRRTVQGEIEDALRTVTRSRETYELTVAGRTDAGVHARGQVAHVDLPREVWAEHHVKLLKRLAGRLPRDVRVWALREAPSGFNARFSAVWRRYAYRVTDNPGGVDPLLRGHVLWHDWPLDVDAMNAAARGLLGEHDFAAYCKKREGATTIRTLQELSLVRGEDGIVTATVRADAFCHNMVRSLIGALLFVGDGHRGPEWPAKVLAAGVRDSAVHVVRPHGLTLEEVGYPADELLAARNKEARNKRSLPGAGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O88028</accession>
    <name>O88028_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6672</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35171">
        <property type="entry name" value="T35171"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630747.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031095.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6672"/>
    <dbReference type="GeneID" id="1102111"/>
    <dbReference type="KEGG" id="sco:SCO6672"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6778"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057759_1_0_11"/>
    <dbReference type="InParanoid" id="O88028"/>
    <dbReference type="OMA" id="PEFAMWC"/>
    <dbReference type="PhylomeDB" id="O88028"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="33530" checksum="1310B965896B3A26" modified="1998-11-01" version="1">MTTRAGAPGKLWAISDLHVGYEENRALVERTRPESDDDWLLVAGDVAETVADIRWALGILADRFRRVVWAPGNHELWTHPKDAVDLRGVARYEHLVEMCRELGVTTPEDPYPVWEGAGGPAVVAPLFLLYDYSFLPAGCATKAEGLEYAQGTGVVCSDEYLLHPDPYPSREDWCRARVAETERRLAAIPADLPTIPVNHYPLHRHPTDVLWYPEFAMWCGTSLTADWHRRFRVETMVYGHLHIPRTTWHEGVRFEEVSVGYPREWRKRPGPPGQLRRILPSTRASAAPSHQEVTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>P46789</accession>
    <name>RL30_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">SCO4720</name>
        <name type="ORF">SCD31.45</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1994-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Loriaux A."/>
                <person name="Brans A."/>
                <person name="Dusart J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="X83011">
        <property type="protein sequence ID" value="CAA58134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S50004">
        <property type="entry name" value="S50004"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628879.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974250.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P46789"/>
    <dbReference type="SMR" id="P46789"/>
    <dbReference type="STRING" id="100226.SCO4720"/>
    <dbReference type="GeneID" id="1100161"/>
    <dbReference type="KEGG" id="sco:SCO4720"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4791"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_0_11"/>
    <dbReference type="InParanoid" id="P46789"/>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="PhylomeDB" id="P46789"/>
    <dbReference type="PRO" id="PR:P46789"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000104614" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="60" mass="6888" checksum="990FEFC98BE5780A" modified="1995-11-01" version="1">MAQLKITQVKSYIGSKQNHRDTLRSLGLKGINTQVVKEDRPEFRGMVHTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q05943</accession>
    <name>GLNR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulatory protein GlnR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">glnR</name>
        <name type="ordered locus">SCO4159</name>
        <name type="ORF">SCD84.26c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Gene" volume="130" first="145" last="150">
            <title>The Streptomyces coelicolor glnR gene encodes a protein similar to other bacterial response regulators.</title>
            <authorList>
                <person name="Wray L.V. Jr."/>
                <person name="Fisher S.H."/>
            </authorList>
            <dbReference type="PubMed" id="7688332"/>
            <dbReference type="DOI" id="10.1016/0378-1119(93)90359-B"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Activates the transcription of the glnA gene.</text>
    </comment>
    <dbReference type="EMBL" id="L03213">
        <property type="protein sequence ID" value="AAA02838.1"/>
        <property type="molecule type" value="Unassigned_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JN0831">
        <property type="entry name" value="JN0831"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628336.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029474.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q05943"/>
    <dbReference type="SMR" id="Q05943"/>
    <dbReference type="STRING" id="100226.SCO4159"/>
    <dbReference type="GeneID" id="1099599"/>
    <dbReference type="KEGG" id="sco:SCO4159"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4223"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="InParanoid" id="Q05943"/>
    <dbReference type="OMA" id="SPMEIRN"/>
    <dbReference type="PhylomeDB" id="Q05943"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <feature type="chain" id="PRO_0000081105" description="Transcriptional regulatory protein GlnR">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="267" mass="28887" checksum="54069CDB07C1BFB1" modified="1994-10-01" version="1">MSSLLLLTNALQPSTEVLPALGLLLHNVRVAPAEGPALVDTPGADVILVDGRRDLPQIRSLCQLLRSTGLSCPLVLIVTEGGLAAVTADWGIDDVLLDTAGPAEVEARLRLATGRQQLGGDDSPMEIRNGDLSVDEATYSAKLKGRVLDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYRFVTPEKPEKGEKSDKSEKAERAEKAERAETPGKAAAETNEAAGARSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKH0</accession>
    <name>Q7AKH0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogen peroxide sensitive repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5206</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629353.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973766.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKH0"/>
    <dbReference type="STRING" id="100226.SCO5206"/>
    <dbReference type="GeneID" id="1100647"/>
    <dbReference type="KEGG" id="sco:SCO5206"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5290"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_0_11"/>
    <dbReference type="InParanoid" id="Q7AKH0"/>
    <dbReference type="OMA" id="QRMEIIK"/>
    <dbReference type="PhylomeDB" id="Q7AKH0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="138" mass="15319" checksum="8E8D9B97027ED15D" modified="2012-05-16" version="1">MSDLLERLRGRGWRMTAQRRVVAEVLDGEHVHLTADEVHSRAVDKLPEISRATVYNTLGELVSLGEVLEVATDKRAKRYDPNAHRPHHHLVCARCGAIRDVHPTGNPLADLPDSERFGFTVSDVEVTYRGTCPNCAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKN1</accession>
    <name>Q7AKN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative permease binding-protein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2933</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36156">
        <property type="entry name" value="T36156"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627159.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028669.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2933"/>
    <dbReference type="GeneID" id="1098366"/>
    <dbReference type="KEGG" id="sco:SCO2933"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2991"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038355_1_0_11"/>
    <dbReference type="InParanoid" id="Q7AKN1"/>
    <dbReference type="OMA" id="APMNNTY"/>
    <dbReference type="PhylomeDB" id="Q7AKN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176021" evidence="2">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="47"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="34536" checksum="7ABF55AA01743C64" modified="2012-05-16" version="1">MRRRTCWALAAALLSASAGCGLTSGSPMVDDVEPGSIGRGKPLDGADLTVTSKEFTEQLVLGAIMGIAFEAAGAEVLDRTGIQGSVGTRAAVENGDADATYEYTGTAWITYLGNSRPIPDPEQQWKAVKEADAKKGLTWLEPARLNNTYALAMNQANYKKYRTKTLSEVTALSKSDPGAVTLCVEGEFANRADGLPGLEKAYGMSLPAGNITQMDTGIIYTQTAKGACTYGEVYTTDGRIKSMNLVVMEDDKKFFPNYNAAPMVRTATLKKWPAIASVLDPVTRALTNDVAQTLNAKVDMDGQDPHQVALDWMKEKGFVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKP2</accession>
    <name>Q7AKP2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Glutamine synthetase</fullName>
            <ecNumber evidence="6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2210</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626461.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028199.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKP2"/>
    <dbReference type="STRING" id="100226.SCO2210"/>
    <dbReference type="GeneID" id="1097643"/>
    <dbReference type="KEGG" id="sco:SCO2210"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2248"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_11"/>
    <dbReference type="InParanoid" id="Q7AKP2"/>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="PhylomeDB" id="Q7AKP2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="89"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB90858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="37192" checksum="3D491607C934AAE9" modified="2012-05-16" version="1">MTFKAEYIWIDGTEPTAKLRSKTKIITAAPAGLDALPVWGFDGSSTNQAEGSSSDCVLKPVFSCPDPIRGGEDILVLCEVLDTDMTPHPSNTRAALAELSERFAAQEPVFGIEQEYTFFKGTRPLGFPEGGFPAAQGGYYCGVGSDEIFGRDVVEAHLENCLKAGLGISGINAEVMPGQWEFQVGPLAPLEVSDQLWVARWLLYRTAEDFEVSATLDPKPVKGDWNGAGAHTNFSTKAMREGYDAIITAAESLGEGSKPMDHVKNYGAGIDDRLTGLHETAPWNEYSYGVSDRGASVRIPWQVEKDGKGYIEDRRPNANVDPYVVTRLLVDTCCTALEKAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKR6</accession>
    <name>Q7AKR6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625074.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978089.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0772"/>
    <dbReference type="GeneID" id="1096195"/>
    <dbReference type="KEGG" id="sco:SCO0772"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.763"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_23_1_11"/>
    <dbReference type="InParanoid" id="Q7AKR6"/>
    <dbReference type="OMA" id="LFPAKEQ"/>
    <dbReference type="PhylomeDB" id="Q7AKR6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="20557" checksum="7DBAA07EBBA8DDFC" modified="2004-07-05" version="1">MDSEVARERALDAAEGLFYARGVRAVGMDEVRGASGVSLKRLYQLFPAKEQLVVACLDRRDLRWRGRLAEYVGRHEEPGARVLAVFDWLGVWFAEPGFRGCAWINAYGELGPASPAVAERVRAHKAAFRAFLDTLAAGAGLPAALGGQLFLLAEGAMVTAGVTGEAEPARQAREAARVLLGAAGVSRPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL0</accession>
    <name>Q8CJL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7137</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031454.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7137"/>
    <dbReference type="GeneID" id="1102575"/>
    <dbReference type="KEGG" id="sco:SCO7137"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7238"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="InParanoid" id="Q8CJL0"/>
    <dbReference type="OMA" id="GHECREL"/>
    <dbReference type="PhylomeDB" id="Q8CJL0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="863"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="924" mass="98646" checksum="BD130414E19AD767" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL4</accession>
    <name>Q8CJL4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acetolactate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6975</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAD55394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031347.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6975"/>
    <dbReference type="GeneID" id="1102413"/>
    <dbReference type="KEGG" id="sco:SCO6975"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7074"/>
    <dbReference type="eggNOG" id="COG3962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_6_0_11"/>
    <dbReference type="InParanoid" id="Q8CJL4"/>
    <dbReference type="OMA" id="RQYHLEY"/>
    <dbReference type="PhylomeDB" id="Q8CJL4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="224"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="420"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAD55394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="624" mass="66358" checksum="F7440BEAE11CA8D6" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJM5</accession>
    <name>Q8CJM5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6566</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAD55380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34923">
        <property type="entry name" value="T34923"/>
    </dbReference>
    <dbReference type="PIR" id="T35008">
        <property type="entry name" value="T35008"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733706.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031010.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6566"/>
    <dbReference type="GeneID" id="1102005"/>
    <dbReference type="KEGG" id="sco:SCO6566"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6671"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="InParanoid" id="Q8CJM5"/>
    <dbReference type="OMA" id="LGHINQP"/>
    <dbReference type="PhylomeDB" id="Q8CJM5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="460" mass="47320" checksum="307B116C1398BEB3" modified="2003-03-01" version="1">MSGAVPCRTLLCPLSGESSQQFVRDFFPHPAPTATFPPKASHADKSRTWPETGGPKADRGGEGLVRRMTARPANTHQARLLQLLRDGGPNSRAQLGDQVDLSRSKLAVEVDRLLETGLVVADGLAASRGGRRSHNVRLNPELRFLGVDIGATSVDVAVTNAELEILGHINQPLDVREGPVAVFEQVLSMAAKLRASGLAEGFDGAGIGVPGPVRFPEGVPVAPPIMPGWDGFPVREALSQELGCPVMVDNDVNLMALGEQHAGVARTQHDFLVVKIGTGIGCGIVVGGEVYRGTTGSAGDIGHIQAVPDGRQCACGNRGCLEAHFSGAALARDATEAAEQGQSAELANRLEANGGLSAADVAAAAAAGDATALDLIREGGRSTGQVIAGLVSFFNPGLVVIGGGVTGLGHNLLAAIRTQVYRQSLPLATGNLPIVLGELGPTAGVIGAARLISDHLFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK25</accession>
    <name>Q8CK25_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1545</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAD55282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733537.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1545"/>
    <dbReference type="GeneID" id="1096971"/>
    <dbReference type="KEGG" id="sco:SCO1545"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1556"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000846_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK25"/>
    <dbReference type="OMA" id="VLRGWGC"/>
    <dbReference type="PhylomeDB" id="Q8CK25"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="30174" checksum="AD620F9295B35B67" modified="2003-03-01" version="1">MMTTTLRPTEPLQRAADGTRSRHYQVCVNSRPVGVLHLGTSPTLGDSVAVIHKLHVDEPDRGRGRGTVAALAAEEVARSWGCRQIEAGVDGDAEAGTRLAQALGYAVRNRTMAKPLGDTPPALPAGSRARPMTPEDFAAWHAYESERYARTWMERGVPEADAHAKARRDHEVLLPQGEATENMLFSVLEHEGERVGTLWLALREDRAFVFDVEADAQHRGRGHGRTLMLLAEAQAITAGRHLIGLNVFAGNTAAERLYESLGYETTRYSYCKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JL1</accession>
    <name>Q93JL1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4983</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629135.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973994.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4983"/>
    <dbReference type="GeneID" id="1100424"/>
    <dbReference type="KEGG" id="sco:SCO4983"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5064"/>
    <dbReference type="eggNOG" id="ENOG50340XE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843992_0_0_11"/>
    <dbReference type="OMA" id="DFPHRSR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="14930" checksum="0D7E447D015D19B0" modified="2001-12-01" version="1">MYEPIRSKSVHSTMAGTTTDFPGRSRDDELDIQLAGHLAALLAVTDELRALAPDTGLDAAAERLAEQVTRLRGGQAPVRLQVAATRQEPRPAALHRRAHTLAARALVVAASRADTAVAILTAERMDAHSAALEPRPLASR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RW0</accession>
    <name>ECTC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-ectoine synthase</fullName>
            <ecNumber evidence="1">4.2.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyldiaminobutyrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ectC</name>
        <name type="ordered locus">SCO1866</name>
        <name type="ORF">SCI39.13</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine</text>
            <dbReference type="Rhea" id="RHEA:17281"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58515"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="4.2.1.108"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ectoine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.108" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626133.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976954.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93RW0"/>
    <dbReference type="SMR" id="Q93RW0"/>
    <dbReference type="STRING" id="100226.SCO1866"/>
    <dbReference type="DNASU" id="1097300"/>
    <dbReference type="GeneID" id="1097300"/>
    <dbReference type="KEGG" id="sco:SCO1866"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1891"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154525_0_0_11"/>
    <dbReference type="InParanoid" id="Q93RW0"/>
    <dbReference type="OMA" id="CVFNPPI"/>
    <dbReference type="PhylomeDB" id="Q93RW0"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033990">
        <property type="term" value="F:ectoine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06978">
        <property type="entry name" value="cupin_EctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01255">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010462">
        <property type="entry name" value="Ectoine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39289">
        <property type="entry name" value="PTHR39289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06339">
        <property type="entry name" value="Ectoine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220158" description="L-ectoine synthase">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01255"/>
        </source>
    </evidence>
    <sequence length="132" mass="14988" checksum="1D323DCFBE72B7B5" modified="2001-12-01" version="1">MIVRSFKEFEGTDRHVKSASGTWESTRIVLAKEKVGFSVHETILYAGTETSMWYANHIEAVVCTKGDAELTDRETGKTYHITPGTMYLLDGHERHTLKVKEDFHCICVFNPPVTGREDHDENGVYPLLTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q93S03</accession>
    <name>Q93S03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6286</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630384.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030795.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q93S03"/>
    <dbReference type="STRING" id="100226.SCO6286"/>
    <dbReference type="GeneID" id="1101727"/>
    <dbReference type="KEGG" id="sco:SCO6286"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6401"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_8_0_11"/>
    <dbReference type="InParanoid" id="Q93S03"/>
    <dbReference type="OMA" id="HFHFANK"/>
    <dbReference type="PhylomeDB" id="Q93S03"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC37887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24083" checksum="B341DBD44A209CB4" modified="2001-12-01" version="1">MTKQERAARTRRALILSAAEVFDQEGFAPASLTMISSRAGVSNGALHFHFANKNAVAEAVQGEALSVLRQIAHAWPEGATPSLQSLVDTSHTLAQRLQDDVVLRAGFGLSGDTTWKERADLRRHWVDWVSSGLTVVALDGALADDVATGDALAVIAATTLGFEAMGRTDPQWSTREMFTRLWRLLLPRISADNGTGPVAPEGTSAPGGVVPGPRWWPERQDAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QP8</accession>
    <name>Q99QP8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.20c</name>
        <name evidence="3" type="ordered locus">SCP1.334</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639596.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639942.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039322.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095099"/>
    <dbReference type="GeneID" id="1095416"/>
    <dbReference type="KEGG" id="sco:SCP1.20c"/>
    <dbReference type="KEGG" id="sco:SCP1.334"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7966"/>
    <dbReference type="HOGENOM" id="CLU_1209276_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28527" checksum="0AD10EAE911B4AFD" modified="2001-06-01" version="1">MAAARPQGPNRRHHTAEEPMDITTRLYLLDLVRQAQQSTAAHAAAVRAAARAAKAATQARDRVDEHARQRPTAQDPEQPDEATGELDQALEEYTDCRGRLQAANRKVTRTFLAARAANRTLGATYAQHARGRARVASRDEVAAGLLDELADVPLALMDAAHAILVQSSAGKDSLVQLHRIATWAKKAGCLHKVVVIHIDLGEESEWPGVRELAQRQAERYGLRFHVLRAEGGLLGLVEKRGMWPDAARRLCTVICTSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACV6</accession>
    <name>Q9ACV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA primase/helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCP1.196</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639791.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039494.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095274"/>
    <dbReference type="KEGG" id="sco:SCP1.196"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8135"/>
    <dbReference type="HOGENOM" id="CLU_018483_2_1_11"/>
    <dbReference type="InParanoid" id="Q9ACV6"/>
    <dbReference type="OMA" id="FAFWRRM"/>
    <dbReference type="PhylomeDB" id="Q9ACV6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="5">
        <location>
            <begin position="215"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="506" mass="56376" checksum="24C152067FA42351" modified="2001-06-01" version="1">MTSPSNETLFEFDPEAVAAQIRAQSPATPLPAQATTERSVGEASANGLLPDTLTDRGNAKLFVKLYANDFRHVPNIGWYRWDTTRWQIDEDDTVLWAAGDLAETIATHDPRGLFTTTALHKHRTRAMSTSGMNAMLTQARSAPGMVLKADRLDADPYALCTPRGVVDLRTGLLRAPDPNKDFHSRSTTVGPQQMPVPRWLRFLTDTFGADAEGQQMIDYLHLLLGYSITGDVGAQILPFLWGTGKNGKSVLLDVMMKLLGDYADAAPPGFLMAKPFEGHPTDLAELHGRRVYVCSEIKPGDKFDEARVKLLTGGDRIKARRMRQDPFSFEPTHKLWLLGNHKPEVGTGGFAFWRRMRLIPFERVVPDDRKIDNLADLLVMEEGPGILAWLIDGARRYLGGDRDLTGPERVRIATTAYAETEDHTGRFYEECCRLGPELRAEQTALYAAYTAWCHNEGAQIISSRAFASRTRELVGLASPKEMKVSNQRKYYPGIGLLTVEERETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADP3</accession>
    <name>Q9ADP3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628195.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974950.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4013"/>
    <dbReference type="GeneID" id="1099449"/>
    <dbReference type="KEGG" id="sco:SCO4013"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4076"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ADP3"/>
    <dbReference type="OMA" id="VPYGWFV"/>
    <dbReference type="PhylomeDB" id="Q9ADP3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="495" mass="52790" checksum="948F37628EEE631D" modified="2001-06-01" version="1">MNKPLRAVAIFCGLLVLGLLIRANWLQYVRAPELASDTKNRRVQIEQFATPRGDIIVGGRAVTGSKETETTDLKYKRTYVDGPMYAPVTGYASQAQGMTLLEKTYDGILTGKDDRLAFQRFADVVSGEGRRAGSVVTTIDPKAQKAAWDGLTDLKGARGAVVALDPQTGKVLAMVSAPSYDPSAFAGSTFKESDRFVELDKKKNKPLANRALRETYPPGSTFKILTAAAALEHGIVTDVDARTDAVSPYPLPQSTNKIGSEAGDAVCNKASMKTAMQHSCNNVFLDAASKLGQDKMRETAEKFGFNEDVYSDDFGDLLATKSLYPEDLDKPGTALTGMGQGSLTSTPMQMALVTAGIANDGKVMQPYVVDEVKGPDLDTLEKTEPAVMSEAVSAETAQKVQEMMEFTAKEGSARRAQIDGITVGGKTGTAQRGVDVNDEVPYGWFVSYGKKDDGSSVAVAVFIDPTDMDISRADISGGGLGAPIAKSVMKAVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJZ1</accession>
    <name>Q9AJZ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7737</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031871.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1103175"/>
    <dbReference type="KEGG" id="sco:SCO7737"/>
    <dbReference type="HOGENOM" id="CLU_1569766_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC22745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="17706" checksum="DF049FD317A8449B" modified="2001-06-01" version="1">MPDGLCGRGRVLPLLERHVVDHSADHGRGPPSAVVSGPVEECGGGLRRFQENVGEIGQSPVQRGTNGVGVLPSPPARGPFGEFVHDGLRSEYVERVGLCEAFPRQGCGSAPCQFVEGHGGVASQRPEVGGTQVVDRLLDAAGGGVRGGRYVGVQEACAYFGGRTHVARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK24</accession>
    <name>Q9AK24_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4902</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029937.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4902"/>
    <dbReference type="GeneID" id="1100343"/>
    <dbReference type="KEGG" id="sco:SCO4902"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4981"/>
    <dbReference type="eggNOG" id="ENOG502ZF06">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144846_0_0_11"/>
    <dbReference type="OMA" id="HGAPVNG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176624" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="122" mass="11835" checksum="C0D13DD22974D6E0" modified="2001-06-01" version="1">MKQSAAKTLGVAALGAAFAAAGAGAATAAPELPDTAQTVDSVARTLPAETVSQVAPGAGNVLEQGRKISHTGLTVAQPVVEQVVAEQLAEGPTEPVAKLLGGVPLKGLPTQGLPVNGLPLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK68</accession>
    <name>Q9AK68_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative antibiotic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4049</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029405.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4049"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="GeneID" id="1099485"/>
    <dbReference type="KEGG" id="sco:SCO4049"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4111"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011790_2_0_11"/>
    <dbReference type="OMA" id="WAITNAM"/>
    <dbReference type="PhylomeDB" id="Q9AK68"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="782" mass="82769" checksum="B07B797983651EC0" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWX3</accession>
    <name>Q9EWX3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1753</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626025.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027956.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1753"/>
    <dbReference type="GeneID" id="1097184"/>
    <dbReference type="KEGG" id="sco:SCO1753"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1771"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069620_0_0_11"/>
    <dbReference type="OMA" id="WLGWRSW"/>
    <dbReference type="BRENDA" id="3.1.3.4">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="113"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="37781" checksum="347642B1DFFA9BE2" modified="2001-03-01" version="1">MRTERKPTRLDRVFARLDREPERPALLDVPEMSRHRIALFAGTLAFYIAIVWAVVITSWLVRLDWQVMFFRPYQQWPEIHAFVDYYVVLGQRGPTAVMVAAWLGWRSWRQHTLRPLLALGVSLLLLNVTVGAAKYGMGRLGPHYATTIGANEMWLGGDIFPSGHTANAVVTWGILAYLASTHRTRRWLSAISAVTSLGVGMSTVYLGTHWLSDVLLGWVAGLLILLALPWFEPLITRAEAWILGLRDRWYTRRDRRSTTRPPLGPPVPVSPPGSGSRPQAPAREPVAAPRTARAPAHLAPGPHTARSDRTPVTPAGSRRPPHSDRHARNTAPTARPLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX58</accession>
    <name>Q9EX58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative merR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631737.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031838.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7698"/>
    <dbReference type="GeneID" id="1103136"/>
    <dbReference type="KEGG" id="sco:SCO7698"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7818"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764876_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EX58"/>
    <dbReference type="OMA" id="VSTVHHW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="41625" checksum="B0FDE1419FB4B0BF" modified="2001-03-01" version="1">MASGGIVGAVEDHWTVGRVAELAHVSVRTLHHYDEIGLVRPSGRTAAGYRAYSADDVERLREVLGYRRLGFGLREIAELVGDPSADAVAHLRRLRGLLLERRARTDAMVAAIDRELDVRAKGLKVTPEEQLEALGARLYDEIGGAYTTTRRTEPRIAARIWDALGDARTVLNVGAGTGSYEPADREVTAVEPSAVMRKQRPAGAAPCVAAAAERLPFADGSFDVAMAVSTVHHWGDPMAGLREMRRVARRVVVLTFDTDEPGWQDRFWLTRDYLPEFATVLAEFPSLAGMAEAIGARAEPVPVPWDCADGLFEAYWRRPEAYLAEHVRRAASVWTKVGPEVERRAVRSLGDDLGSGRWAERNSDLAGLEAADLGLRLLIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-10" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Q3</accession>
    <name>ENO1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase 1</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno1</name>
        <name type="ordered locus">SCO3096</name>
        <name type="ORF">SCE41.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627314.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975715.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F2Q3"/>
    <dbReference type="SMR" id="Q9F2Q3"/>
    <dbReference type="STRING" id="100226.SCO3096"/>
    <dbReference type="PRIDE" id="Q9F2Q3"/>
    <dbReference type="GeneID" id="1098530"/>
    <dbReference type="KEGG" id="sco:SCO3096"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3158"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_11"/>
    <dbReference type="InParanoid" id="Q9F2Q3"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="PhylomeDB" id="Q9F2Q3"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000133976" description="Enolase 1">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="426" mass="45483" checksum="63AED7B7A4E15001" modified="2001-03-01" version="1">MPSIDVVVAREILDSRGNPTVEVEVGLDDGSTGRAAVPSGASTGAFEAIELRDGDPSRYLGKGVEKAVLAVIEQIGPELVGYDATEQRLIDQAMFDLDATDNKGSLGANAILGVSLAVAHAASEASDLPLFRYLGGPNAHLLPVPMMNILNGGSHADSNVDIQEFMIAPIGAESFSEALRWGAEVYHTLKKVLKNKGLATGLGDEGGFAPNLGSNREALDLILEAIKEAGYTPGEQIALALDVAASEFYKDGSYAFEGKNRSAAEMTEYYAELVEAYPLVSIEDPLFEDDWDGWNTITAKLGDKVQLVGDDLFVTNPERLARGIEENSANALLVKVNQIGSLTETLDAVELAQRNGFKCMMSHRSGETEDVTIADLAVATNCGQIKTGAPARSERVAKYNQLLRIEEILDDAAVYAGRSAFPRFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2R4</accession>
    <name>Q9F2R4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome biogenesis related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4475</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628641.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029680.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4475"/>
    <dbReference type="GeneID" id="1099915"/>
    <dbReference type="KEGG" id="sco:SCO4475"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4544"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2R4"/>
    <dbReference type="OMA" id="VWAFITW"/>
    <dbReference type="PhylomeDB" id="Q9F2R4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="7">
        <location>
            <begin position="149"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC08382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="40560" checksum="9A3192905DE632A3" modified="2001-03-01" version="1">MTLAAATELAAATNENLANVSNTLIYSSMAVYTLAFFAYIAEWLFGSRSKVGRTAAALTSDTAGAKAGARSGPAVTVKKAGTTAVLERPEVVVRTASGTRDVPDGPGAHGGTEKGDLYGRVAISLTVLAFAVEAGGVLTRALSVQRAPWGNMYEFNITFTTVAVGVYLALLALKKNVRWLGLPLTTTVLLDLGLAVTVLYTASDQLVPALHSYWLYIHVSTAIFCGAVFYVGAVSTILYLFKDSFENKLASGGTPGRFASSVLDRLPAAASLDKFAYRVNAAVFPLWTFTIIAGAIWAGDAWGRYWGWDPKETWSFITWVAYAGYLHARATAGWKGRKAAYLALIAFGCWLFNYYGVNIFVSGKHSYADVGLGALQSVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F382</accession>
    <name>Q9F382_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628574.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029635.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4406"/>
    <dbReference type="GeneID" id="1099846"/>
    <dbReference type="KEGG" id="sco:SCO4406"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4474"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081211_1_0_11"/>
    <dbReference type="OMA" id="GRIQFIA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="72"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="22601" checksum="AB74531EA741982D" modified="2001-03-01" version="1">MQTFDTPAPISALLDVPAGRIRFIAADRTDTTVEVLPADASKGRDVKVAEQTRVEFGDGVLRIETGVKHPFMGASGAVEVTVRLPAGSRVEAKAAAAEFRGVGRLGDVGFEGAHGPVKLDEAASVRLATAAGDISVGRLDGPADIRTEKGDIRIAEAVRGEVVLRTGSGDLSVGAAAGVSASLDAGTSYGRVHNALRNTDGTPGLTIHATTAHGDITARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3B3</accession>
    <name>Q9F3B3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7562</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631605.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031747.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7562"/>
    <dbReference type="GeneID" id="1103000"/>
    <dbReference type="KEGG" id="sco:SCO7562"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7676"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_2_11"/>
    <dbReference type="InParanoid" id="Q9F3B3"/>
    <dbReference type="OMA" id="YAVDDEY"/>
    <dbReference type="PhylomeDB" id="Q9F3B3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="78"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="29219" checksum="F19F6E28EC9F1FAA" modified="2001-03-01" version="1">MVKAVNTRSVDQELVKGPVDKAMEVLDALVQPGGPHRLGEIARRTGLTKPTVHRHLRTMAEYGFAEPAEGGSYRPGPRLLGLAAAALSDSRVLELTRPALADLRRRTGHVAFYAVRHASDAVYLEQSEPAREYRMGTRPGHRTPLHTCGVGLAMLSALPTEEVAAVLDAPDLEARTPNTPADPAALRAVLARAAVCGYAVDDEYDEPDVRSVAAPVLDAEGRAVGAIGIAGLTFTLDPGSVEVFGPMVRAAARTVSAGLGARTPVLGVVDTVRGGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC34</accession>
    <name>Q9FC34_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7050</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631112.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031402.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7050"/>
    <dbReference type="GeneID" id="1102488"/>
    <dbReference type="KEGG" id="sco:SCO7050"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7154"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_3_1_11"/>
    <dbReference type="InParanoid" id="Q9FC34"/>
    <dbReference type="OMA" id="FARYCAR"/>
    <dbReference type="PhylomeDB" id="Q9FC34"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="2">
        <location>
            <begin position="88"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="413" mass="42598" checksum="7EAE9B0DFB02360C" modified="2001-03-01" version="1">MFAGRTRPGQRGDVRGRSYVCGMTIGFSSRAVRATCMLCAAGLLTLVPATAAARAGRPDPGPPGDAAAARSSPLYRSGTQVRPHPAAPRVPEVSALSWVVADAGTGDVLAANDAHRELPPASTLKTLFALTVLPALPGGIRHEVGPEDLSGIGPGSSLVGVVEGQTYRVSDLWNGVFLNSGNDAVHVLASLTGGWSATAARMQAEARALGARDTHVRSPDGYDAPGQVSSAYDLAVFGREGLRRPDFARYCAKVDAMFPGRDGSSYGIMNTNRLLTGADGVQPYPGLIGVKNGYTSNAGNTLIAAARRDGRTLVVTVMNPQEGGGHAVYEEARALLDWGFEAAGEVDPVGSLDPEDHRPRQGPQAVPAAVSAAKPAEDVPGWPETGAILGVAGLGAGVMALALRIKLVRDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCF9</accession>
    <name>Q9FCF9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4211</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628386.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029503.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4211"/>
    <dbReference type="GeneID" id="1099651"/>
    <dbReference type="KEGG" id="sco:SCO4211"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4274"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097563_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCF9"/>
    <dbReference type="OMA" id="SHYLGHD"/>
    <dbReference type="PhylomeDB" id="Q9FCF9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="202" mass="22015" checksum="65353D8F4160914F" modified="2001-03-01" version="1">MGDGCGLRQGEILGVAVDAIDFDSDTLHVVQQLKLSRSKAVFAPPKGGKLRDVPLPRPVADALRAHTRRFPPVEITLPWKVADGPPVTKRLVFTGPRGGHVWRTSLNEEAWKPALAAAGVIPAPERGRPYAESRENGMHALRHFYASVLLDAGENIKALAEYLGHSGPGLTLRVYAHLMPSSRERTSRAVSDVYSKLLHPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH7</accession>
    <name>Q9FCH7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4192</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628367.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4192"/>
    <dbReference type="GeneID" id="1099632"/>
    <dbReference type="KEGG" id="sco:SCO4192"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4256"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063232_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="358" mass="40677" checksum="1A48D5999F00DBA8" modified="2001-03-01" version="1">MHRLPHRARKALVHHLVESRRLRGRGEVLTGHHNVNYVRRSGLVLALLLGAVPFTRFKYRVPLRAVEVVPRIWQREAEVLGVVCRYLREVPRCLADLGNGSVHGYRAGRVLSDSGPTGRVGEELMRSFASFFVRTASVPVAELPARPEGWPRDGDTQGFLDWLVHFTERRVHRPNRDRFGALFDAVGVPEDAMARFAAGHRCRAVRPFRLLHTDVHRANVVVRGRRLAVIDWELAILGDPLHDLATHLVRMAYGKEEQGRMVDLWAEAMADAGFTDLTAGLHEDLPVYVAFEYAQSVFPDVMRAAIDLPQDARTEHFRTAADRVERAVRRAREPLRLVDVPDREQVVEALRVWHATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL4</accession>
    <name>Q9FCL4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631831.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031924.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7800"/>
    <dbReference type="GeneID" id="1103238"/>
    <dbReference type="KEGG" id="sco:SCO7800"/>
    <dbReference type="HOGENOM" id="CLU_2738173_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="71" mass="7733" checksum="FE53D1E04FE59AAD" modified="2001-03-01" version="1">MSDAALVEIRDYLVSRIVEAENEGWLGEVERLQVSLAGAENEIKKLESSPRGSTLPGIPDVPSSRPRRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3L1</accession>
    <name>Q9K3L1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1049</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625344.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027544.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1049"/>
    <dbReference type="GeneID" id="1096472"/>
    <dbReference type="KEGG" id="sco:SCO1049"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1044"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K3L1"/>
    <dbReference type="OMA" id="SHEPYTP"/>
    <dbReference type="PhylomeDB" id="Q9K3L1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176721" evidence="2">
        <location>
            <begin position="29"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="4">
        <location>
            <begin position="142"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB96034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="387" mass="41093" checksum="81BE8845A603731A" modified="2000-10-01" version="1">MSARPARRRVAVVGTGAIVTGSHLPALAAHADRTELVAAVDVDPERLDAFRAQAPGDVAGYASTDAMLDAVRPDLVLVGTPPSLHREQTVAALKAGAWVLCEKPLCLSLAEYDDIAAAEEASGAYASVIFQHRYGSGAAHARDLIASGELGAPLVAHCQTTWHRDAAYYAVPWRGRWSTEGGGPTMGHGIHQYDLLLHLLGPWAEIRAMASRLVHDTESEDVSTALVRFGSGALATVVNSVLSPEEVSRIRVDCADATVELTHLYGHRNDDWTYTPARHVAPARAAAWRTPGADVPSSHTAQLGAVLDAWDAGARPPGSGQEARATLEFAAALYKAAFTGRPVRASEIAAGDPFYSAMHGDHPDWAPENPRNGPRLECSQRVGPPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M2</accession>
    <name>Q9K3M2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1038</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625333.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977791.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1038"/>
    <dbReference type="GeneID" id="1096461"/>
    <dbReference type="KEGG" id="sco:SCO1038"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1033"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_3_0_11"/>
    <dbReference type="OMA" id="VDWDLYP"/>
    <dbReference type="PhylomeDB" id="Q9K3M2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB96023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12682" checksum="AFAE79A56A37E965" modified="2000-10-01" version="1">MAFWTAALPLVAAAEWQSETWRTLEYADGSGRALGLLRSDSPPEPRPRLHLDLFTDSAEEQRAEVRRLIGLGARAVEWDLYPPDPDFVVLADPDDNIFCVVDLSHAPSGGDRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K464</accession>
    <name>Q9K464_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7221</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="J. Am. Chem. Soc." volume="134" first="7359" last="7366">
            <title>Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor.</title>
            <authorList>
                <person name="Chemler J.A."/>
                <person name="Buchholz T.J."/>
                <person name="Geders T.W."/>
                <person name="Akey D.L."/>
                <person name="Rath C.M."/>
                <person name="Chlipala G.E."/>
                <person name="Smith J.L."/>
                <person name="Sherman D.H."/>
            </authorList>
            <dbReference type="PubMed" id="22480290"/>
            <dbReference type="DOI" id="10.1021/ja2112228"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631277.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031521.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="PDB" id="3V7I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.90 A"/>
        <property type="chains" value="A=1-389"/>
    </dbReference>
    <dbReference type="PDBsum" id="3V7I"/>
    <dbReference type="SMR" id="Q9K464"/>
    <dbReference type="STRING" id="100226.SCO7221"/>
    <dbReference type="GeneID" id="1102659"/>
    <dbReference type="KEGG" id="sco:SCO7221"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7321"/>
    <dbReference type="eggNOG" id="COG3424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034992_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K464"/>
    <dbReference type="OMA" id="LEYMEQT"/>
    <dbReference type="PhylomeDB" id="Q9K464"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="2">
        <location>
            <begin position="99"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3V7I"/>
        </source>
    </evidence>
    <sequence length="389" mass="41699" checksum="B15C6F9484D098F2" modified="2000-10-01" version="1">MAAYLCAPAVIHGEHSVETREIVEEVRGRHPHAPWAPRIDGIAASTGIESRGWMLPLEAAVAPGGGGDLGAAREALVRDGFTEQDANRAIAALKAVPASQTVQERTAPAWEAVQAYGERAARGALQIAGLDVADVDCLITSNSTTPALPGLDVALANRLPLRGDTMLLPATQWACVAGTRSLALAADLVAADPDRVVLVVISEALSTTYQPADDTLESLIVRLLFADTAVAAVVTGRPRPESVLRLDAAWHHTLPGTRDLHRLETRADGTHFVMDRRGPRAVQETVTAMWEWLRVRYEDDPSSWHPDVLLAHPGGTRVLEYMEQTMPDEWPSGLLSYSRDSYTSGNRGGAAVFDILRRAHDAGQKTGSRAVLYAAAPGLTATALEGEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K467</accession>
    <name>Q9K467_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iron transport lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7218</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631274.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031519.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7218"/>
    <dbReference type="GeneID" id="1102656"/>
    <dbReference type="KEGG" id="sco:SCO7218"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7317"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_7_2_11"/>
    <dbReference type="InParanoid" id="Q9K467"/>
    <dbReference type="OMA" id="TRNMDAV"/>
    <dbReference type="PhylomeDB" id="Q9K467"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176736" evidence="1">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="345" mass="37271" checksum="92846E5077F22CC8" modified="2000-10-01" version="1">MPNRARPAALALALAPVLAFAVSGCGADVSPEAGEGAGARASSGGHYPVTVENCGEKLTFEKAPRRVVTNDVGITEIMFALGLEDHMAGYVMPDDKGDLTKVPWKDGYRKTTWLSKERINKELVLDARADLVFAGWNYGFSEGDGFTPQALRRVGIDSYLLSESCRNGQGKARGVMPPLDALYTDLRNLGKVFDVEDRAETLVARFRDQVAQAQAKAPKGADRPRVFLYDSGEDKPLTSGAYAGPHDIITKAGGDHVMKDLKDSWTTVGWETVVARDPEVIVINDYGDTTAEQKRRFLTSYKPLANVSAVKNDRIFTLAYVDLVESPRNPAAIGSLAAYLGGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K469</accession>
    <name>Q9K469_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative FecCD-family membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7216</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631272.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031517.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7216"/>
    <dbReference type="GeneID" id="1102654"/>
    <dbReference type="KEGG" id="sco:SCO7216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7315"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_11"/>
    <dbReference type="InParanoid" id="Q9K469"/>
    <dbReference type="OMA" id="AMVYWSF"/>
    <dbReference type="PhylomeDB" id="Q9K469"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033214">
        <property type="term" value="P:siderophore-dependent iron import into cell"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB94639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="368" mass="37384" checksum="F86623E7FC5B75F5" modified="2000-10-01" version="1">MATLRDRIPAAPPDRTGNSGPPPARRASLPLLVAGLCVALPVSLACGACIGASGLSWSEALHHLWAGLTGGTIDADDVAAYTIVWELRFPRAVLAAVVGAGLASVGVAVQAMVRNALADPFVLGISSGAAVGANAVLIFGAFGALGLWALSTAAFLSALAAMVLVYAVARTPRGLTPLRLVLTGTAMYYGFSAVTTFMVFAAEHGEAARSAMMWLLGSLGGANWSSVPIAAGAVLGGILHLGWSARRLNALAMGDETAAALGVDPGRLRKELFLTASAVTGAVVAVSGAIGFVGLMVPHAARMLVGADHRRLLAVAPLGGAVLLVWVDILSRVVLAPAELPLGVLTAAIGVPCFVLLMRRRTYTFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU7</accession>
    <name>Q9KXU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4294</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628466.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974680.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4294"/>
    <dbReference type="GeneID" id="1099734"/>
    <dbReference type="KEGG" id="sco:SCO4294"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4362"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KXU7"/>
    <dbReference type="OMA" id="IRVMLPA"/>
    <dbReference type="PhylomeDB" id="Q9KXU7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB93054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="91" mass="9570" checksum="4BD7EE768C2AAD7E" modified="2000-10-01" version="1">MSVTVRIPTILRTYTGGKAEVSADGANLGEVISDLEKNHTGIAARVLDDQGKLRRFVNVYVNDDDVRFEQGLQTATPDGAGVSIIPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXY6</accession>
    <name>Q9KXY6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2429</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626673.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028347.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1097863"/>
    <dbReference type="KEGG" id="sco:SCO2429"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2470"/>
    <dbReference type="eggNOG" id="ENOG502ZBDW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083369_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KXY6"/>
    <dbReference type="OMA" id="LIFDQYV"/>
    <dbReference type="PhylomeDB" id="Q9KXY6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176748" evidence="1">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="23275" checksum="13C55012BFA1010C" modified="2000-10-01" version="1">MATGLLLSGTIAALLTSVLPAQQHQSSGGFEDPPPDKIVIKVATVNGSGCPQGTAAVAVSGDNTAFTVTYSDYLAQAGGDSAPTDFRKNCQLNLLVHVPQGFTYAVASADYRGFAALQPGAKGTQRASYYFQGSPNTEYRTHPFAGPYDDNWQATDSTDWAQLVWAPCGVQRNFNINTELRVSTGTSDPDEVSFMTMDSTDGDISTVYHLAWKECPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY18</accession>
    <name>Q9KY18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative small hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2372</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028310.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2372"/>
    <dbReference type="GeneID" id="1097806"/>
    <dbReference type="KEGG" id="sco:SCO2372"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2412"/>
    <dbReference type="eggNOG" id="ENOG5031TAX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2262367_0_0_11"/>
    <dbReference type="OMA" id="CGWLAMG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="102" mass="10433" checksum="3BBAA753A1EDB7EC" modified="2000-10-01" version="1">MMASFGQGSRRHPRSRGRTWSRTGPDRATLAIVGVVCAVAGFFALGIVLGPVATVCGWLAMGRTWAGSRSVPAVVAVVLGAIDTLLALIGLIGATTPGHGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY30</accession>
    <name>Q9KY30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2360</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626607.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2360"/>
    <dbReference type="GeneID" id="1097794"/>
    <dbReference type="KEGG" id="sco:SCO2360"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KY30"/>
    <dbReference type="OMA" id="LFIYWIG"/>
    <dbReference type="PhylomeDB" id="Q9KY30"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329861" evidence="3">
        <location>
            <begin position="32"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="293" mass="30321" checksum="E7D4F279DA4D98BF" modified="2000-10-01" version="1">MRSSSGSLQPRFSSVVVMTAIAAQPAVDSGAAPQWINDLMDALGAPGAGLAIALENLFPPLPSEVILPLAGFAASSGRMSLIAVLLWTTAGSVIGALALYGIGALLGRDRTVAIAGKLPLVKVSDIEKTEAWFLRHGTKAVFFGRMIPIFRSLISVPAGVERMRLPVFLALTTLGSAIWNTVFVLAGYALGDNWSEVSGIASTYSKVILAAAALAVVVFVVMRLLRPGAGHRRRGRGDDGRQDIRPPADDDGHPGTGGGAGDGDGGFSEPGAPRAGTPGGSAHRPGRRARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY32</accession>
    <name>Q9KY32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2358</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626605.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976446.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2358"/>
    <dbReference type="GeneID" id="1097792"/>
    <dbReference type="KEGG" id="sco:SCO2358"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2397"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_0_11"/>
    <dbReference type="InParanoid" id="Q9KY32"/>
    <dbReference type="OMA" id="HINAIFD"/>
    <dbReference type="PhylomeDB" id="Q9KY32"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB92834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="23237" checksum="544A70F43CAF2CBE" modified="2000-10-01" version="1">MILAEDSTLLREGLVRLLAEEGHEVLAAVGNAELLLKAVAEDPPDVVVADVRMPPTHTDEGLRAALEIRGRWPGVGVLVLSQYVEKRYATELLTGETEGVGYLLKDRVVQVDEFLDALERVAAGRAAFDPEVVRQLLGRTTHTDLLARLTVRERDVLAEMAQGHTNAAIARRLHISQSGVEKHTNAIFDKLELTGGEGYSRRVLAVLRYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY99</accession>
    <name>Q9KY99_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chinitase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5003</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629155.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029996.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5003"/>
    <dbReference type="CAZy" id="CBM16">
        <property type="family name" value="Carbohydrate-Binding Module Family 16"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="DNASU" id="1100444"/>
    <dbReference type="GeneID" id="1100444"/>
    <dbReference type="KEGG" id="sco:SCO5003"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5082"/>
    <dbReference type="eggNOG" id="COG3469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KY99"/>
    <dbReference type="OMA" id="WYGQAAY"/>
    <dbReference type="PhylomeDB" id="Q9KY99"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176763" evidence="6">
        <location>
            <begin position="37"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="188"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="281"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB92596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="571" mass="58102" checksum="DCD7AD7BEC5E4F72" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYE0</accession>
    <name>Q9KYE0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4130</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628308.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029454.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4130"/>
    <dbReference type="GeneID" id="1099570"/>
    <dbReference type="KEGG" id="sco:SCO4130"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4192"/>
    <dbReference type="eggNOG" id="ENOG5033DYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008053_0_0_11"/>
    <dbReference type="OMA" id="EYGGFTY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="27538" checksum="C3C875F59C0DD392" modified="2000-10-01" version="1">MSLGDDHQSSGDYGGAGRTRLRLPEDEGGPRRGGRSSSRSLVTVVGVVVLLIAAIAFANRGGSDSASGEDGDGNKPKTSATAPSGTRPVQSGFAHDAQGAQSAAANYAVALGSDGMFDKARRHGIVQALADPGWVDRLQSGFDADYSPALLKRIGLDENGKAPKGVTFVNRTLPAGTKVTSFSDSAASVEVWCNGLFGLAGEKTTNPVTSSWFTVTVRLSWDGSDWKVTETSQKNGPTPVPGDSPVSGADELSKAVKEFGGFTYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYN1</accession>
    <name>Q9KYN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631407.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7354"/>
    <dbReference type="GeneID" id="1102792"/>
    <dbReference type="KEGG" id="sco:SCO7354"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7457"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_3_11"/>
    <dbReference type="InParanoid" id="Q9KYN1"/>
    <dbReference type="OMA" id="QRWGSRQ"/>
    <dbReference type="PhylomeDB" id="Q9KYN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="802" mass="84682" checksum="7D1EAD3FAE4B50E9" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYV8</accession>
    <name>Q9KYV8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3187</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627401.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975630.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3187"/>
    <dbReference type="GeneID" id="1098621"/>
    <dbReference type="KEGG" id="sco:SCO3187"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3247"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KYV8"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="PhylomeDB" id="Q9KYV8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="10831" checksum="0893F0F52B8EA8FA" modified="2000-10-01" version="1">MPTYQYQCTECGEGLEAVQKFTDDALTECPNCQGRLKKVFSAVGIVFKGSGFYRNDSRGSSSSSSPASSSSKTASSSSSDSGSSSSSSASSSGSGSSSGSGSSSAGTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ18</accession>
    <name>Q9KZ18_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TPR_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626470.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028206.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2219"/>
    <dbReference type="GeneID" id="1097652"/>
    <dbReference type="KEGG" id="sco:SCO2219"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2256"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116756_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ18"/>
    <dbReference type="OMA" id="YPEERAH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041656">
        <property type="entry name" value="TPR_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12688">
        <property type="entry name" value="TPR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPR_5" evidence="1">
        <location>
            <begin position="82"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB90867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="205" mass="22145" checksum="00A3F8275894E932" modified="2000-10-01" version="1">MPHGAPARGPVIDTGAGREVLRSPGAVVRSPCESGPVDQDWEERVRAAWAAFDDYAEEDAADFRAVVDALADELPADNPLGLFERACAWDSTGHSDRAVPLYREALERGLGEASAYKGRRAKIQLSSSLRNTGHPEEGVKLLSPELVAPSDELDDAVRATLALCLSSMGRDREGLSLVLGALAPHLPRYQRSMATYARLLVEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ61</accession>
    <name>Q9KZ61_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3088</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627307.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028760.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3088"/>
    <dbReference type="GeneID" id="1098522"/>
    <dbReference type="KEGG" id="sco:SCO3088"/>
    <dbReference type="HOGENOM" id="CLU_2572254_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="8372" checksum="8E1203E56D61D707" modified="2000-10-01" version="1">MLGDVVNRPGRTAPCSQPLFRFRGATSVGRAGPVSYLRMTADPDGGAGENGAGALVETVKSRHSAYSAGGRTQGCWHVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZF2</accession>
    <name>Q9KZF2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO7001</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631066.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031370.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7001"/>
    <dbReference type="GeneID" id="1102439"/>
    <dbReference type="KEGG" id="sco:SCO7001"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7103"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KZF2"/>
    <dbReference type="OMA" id="RIGFTVI"/>
    <dbReference type="PhylomeDB" id="Q9KZF2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="353" mass="37614" checksum="087D12C631D4FB36" modified="2000-10-01" version="1">MDHLLPAGIALGAGLLGAFLLRMLLRWLAGHAGRTRWGGDDVIVAALRTVAPWAAVAAGVAGAAAALPLTRAVQHGVNQVLTVLLIFVATVTAARVVAGLVRTVTTSRSGVAGSATIFVNITRILVLAIGFLVMLQTLGVSIAPMLTALGVGGLAVALALQDTLANLFAGIHILASKTVQPGDYIQLSSGEEGYVEDINWRQTTVRELSNNLVVIPNGQLAKSNMTNFMRPEQRLTVLVQVGVSYDSDLDHVERVTTEVIAEVMAEVSGAVPDHEPAIRFHTFGDSRIGFTVILGVGEFSDQYRIKHEFIKRLHRRYRAEGIRIPSPARTVALQQGAVVLPQQRAGEDVVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZF6</accession>
    <name>Q9KZF6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631062.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031366.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6997"/>
    <dbReference type="GeneID" id="1102435"/>
    <dbReference type="KEGG" id="sco:SCO6997"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7099"/>
    <dbReference type="eggNOG" id="ENOG50330QX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125494_0_0_11"/>
    <dbReference type="OMA" id="IAELTFD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="17952" checksum="AE0BB361A19CBC52" modified="2000-10-01" version="1">MSDLNDDRDEHDDRDERDRKLHDGLLEEELRQAAAILDPVPAELRRTAVDAFVLHDLDARVAELTFDSLVDGIPVRGETDPPRMLTFQSDGVTVDVEVTAEGLIGQLLPPGPAGIEVLTGPREHVRLTADDMGRFTGEAPPAGPFALRLRTGREVVVTEWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZQ6</accession>
    <name>Q9KZQ6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO2897</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627123.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975913.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2897"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="GeneID" id="1098330"/>
    <dbReference type="KEGG" id="sco:SCO2897"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2956"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_6_0_11"/>
    <dbReference type="InParanoid" id="Q9KZQ6"/>
    <dbReference type="OMA" id="ADWAGKT"/>
    <dbReference type="PhylomeDB" id="Q9KZQ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="49"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="323"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="756" mass="79603" checksum="AA9AC5002BB8D8E8" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZR0</accession>
    <name>Q9KZR0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627119.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028650.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2893"/>
    <dbReference type="GeneID" id="1098326"/>
    <dbReference type="KEGG" id="sco:SCO2893"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2952"/>
    <dbReference type="eggNOG" id="COG4758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075817_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZR0"/>
    <dbReference type="OMA" id="FAFWGGG"/>
    <dbReference type="PhylomeDB" id="Q9KZR0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="30755" checksum="D47E97602E74C1ED" modified="2000-10-01" version="1">MTDDAPELRASDADRERVAEVLRDALAEGRLDMAEFEERLDATYSARTYGDLAPITRDLPVGGAGAAPRVSMTKEPERDGGWAGRITGGEGSSTWAVAVMSGFQRKGRWTVPRRFNCFAFWGGGEIDLRDADFAAGEVVINCVAIMGGMNVVVPPGVEVVVRGIGFMGGFDHSEEGVPGDPGAPRVIVTGFAFWGGVGVERKVTRAERQRLKEERRQEKLERRQERERERLERGSGRRELDASRSDGHDRHGLDGLHDLHGGRERELERERERRRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZS5</accession>
    <name>Q9KZS5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2876</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627104.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028640.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2876"/>
    <dbReference type="GeneID" id="1098310"/>
    <dbReference type="KEGG" id="sco:SCO2876"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2936"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_6_11"/>
    <dbReference type="InParanoid" id="Q9KZS5"/>
    <dbReference type="OMA" id="FIDYLAH"/>
    <dbReference type="PhylomeDB" id="Q9KZS5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="208" mass="23450" checksum="60D37BAC6D4013C1" modified="2000-10-01" version="1">MAPSPDIRCRSRPVGRRMTAMTLATPTLDTDRLRLRPFTEDDAGFLYAMHSSRHVMRYWDSPPWTERARAGRFVGMCRKMADEGTGVRVAVDRASDGAFVGWCCLAEWNPVYRSASLGYCLDEAMWGHGYATEAAHALLRWAFDTLDLNRVQAEADTRNAASARVLEKVGFVREGTLREDCVVDGEVSDSWVYGLIRRDWRPSAAPVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZX7</accession>
    <name>VGB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Virginiamycin B lyase</fullName>
            <ecNumber>4.2.99.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Streptogramin B lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">vgb</name>
        <name type="ordered locus">SCO4449</name>
        <name type="ORF">SCD6.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Biochemistry" volume="40" first="8877" last="8886">
            <title>Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis.</title>
            <authorList>
                <person name="Mukhtar T.A."/>
                <person name="Koteva K.P."/>
                <person name="Hughes D.W."/>
                <person name="Wright G.D."/>
            </authorList>
            <dbReference type="PubMed" id="11467949"/>
            <dbReference type="DOI" id="10.1021/bi0106787"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">27 uM for quinupristin</KM>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Vgb family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.-"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628616.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029662.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KZX7"/>
    <dbReference type="SMR" id="Q9KZX7"/>
    <dbReference type="STRING" id="100226.SCO4449"/>
    <dbReference type="PRIDE" id="Q9KZX7"/>
    <dbReference type="DNASU" id="1099889"/>
    <dbReference type="GeneID" id="1099889"/>
    <dbReference type="KEGG" id="sco:SCO4449"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4519"/>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054751_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZX7"/>
    <dbReference type="OMA" id="ALWFTEW"/>
    <dbReference type="PhylomeDB" id="Q9KZX7"/>
    <dbReference type="SABIO-RK" id="Q9KZX7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01282">
        <property type="entry name" value="VirginiamycinB_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011217">
        <property type="entry name" value="Streptogrm_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026412">
        <property type="entry name" value="Streptogrm_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000313778" description="Virginiamycin B lyase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11467949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="299" mass="31124" checksum="0ADB9DCB4FBC81AF" modified="2000-10-01" version="1">MNEINESYDTDSVREFTVSDADAGPYALAEGPDGALWFTLVHRGAVARRDPDDGRVTVHPVGDGPTVIAPGPDGALWFTEYRAHRIGRITPEGHYASFAPLTPEGGPFGITAGPDGAMWFTLSSADRVGRVTMDGEVTEHPAPGAFPSALTAGPDGALWCTLNQGNAIGRLTPDGHGTAYPLPTPGAAPVGIAAGPDGALWFTEIGAGRIGRITVTGDLTEYPLSDPAARPHAVTAGPNGALWFTEWGSGRVGRITVDGRVTSYPLSRTDCEPHGIAVHDGALWCALETGSLARIQVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZX8</accession>
    <name>Q9KZX8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4448</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628615.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029661.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4448"/>
    <dbReference type="GeneID" id="1099888"/>
    <dbReference type="KEGG" id="sco:SCO4448"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4518"/>
    <dbReference type="eggNOG" id="ENOG502ZXN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085950_0_0_11"/>
    <dbReference type="OMA" id="QDGFEPP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043755">
        <property type="entry name" value="DUF5701"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18959">
        <property type="entry name" value="DUF5701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="24292" checksum="901DFA12ACE563BA" modified="2000-10-01" version="1">MTDSTHSPAPGAAAEFDRQVRTLVALGYPALSGRTPERFAELVAPLRAEAVARTDRAAYAAYEPAATGRVPFVLVVGRELAPVERTMPLTTLRGGRLPGFVDRSFEPGSLARFVATGTTRPPGRDGVHLLFDVERGEEFCGAVPGDALATVAERGRTPLTVEEGIALLTHVPEVLVKNKCFSLGGSRCGDRRVPALWISKRAPKLGWCWEGNPHTWLGMASAGARHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L028</accession>
    <name>Q9L028_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable LacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7027</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631091.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972117.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7027"/>
    <dbReference type="GeneID" id="1102465"/>
    <dbReference type="KEGG" id="sco:SCO7027"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7131"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_4_11"/>
    <dbReference type="InParanoid" id="Q9L028"/>
    <dbReference type="OMA" id="TVGSNNW"/>
    <dbReference type="PhylomeDB" id="Q9L028"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="36431" checksum="82BA87D796027FF8" modified="2000-10-01" version="1">MTLAEVAKEAGVSAPTVSKVLNGRSDVSSTTRARVERLLEVHGYRRRNASPPRSPLVELVFHELDSVWAMELVRGVEDVAKANRTEVVLTRSGTRHAPAPDWIEGVLRRRPLGVVLVFSSLPAEVKQRLRSWNIPFVIVDPAGDPDPDVPSVGSANWAGGLAATRHLTDHGHERVAIITGFEDMLCSLARLDGYRSAMTMAGLPIDPALVRYGDYSVESGFEHGMDLLAGPGRPTAVFAGSDLQALGVLEAARVRGLRVPQDLSVVGYDDVPLAQWSSPPLTTVHQPLRHMAEEATRMLFRPDEPGRAGRRIELATHLVVRQSTAPPGGSAAAPGGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0F7</accession>
    <name>Q9L0F7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative DEAD-box RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4685</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029814.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4685"/>
    <dbReference type="GeneID" id="1100126"/>
    <dbReference type="KEGG" id="sco:SCO4685"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4757"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_11"/>
    <dbReference type="InParanoid" id="Q9L0F7"/>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="PhylomeDB" id="Q9L0F7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="272"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="473" mass="50329" checksum="7A2CCBA86E1D175C" modified="2000-10-01" version="1">MNRTGMNDRMNDRPARTGKARTRALAVQGEFAHPETLTPALPAAARFADLDMPAELLAALESQGVTVPFPIQAATLPNSLAGRDVLGRGRTGSGKTLAFGLALLARTAGRRAEPGQPLGLVLVPTRELAQQVTDALRPYARSVKLRLTAVVGGMSIGRQASALRGGVEVVVATPGRLKDLIDRGDCRLNQVSVTVLDEADQMADMGFMPQVTALLDQVRPEGQRMLFSATLDRNVDLLVRRYLSDPVVHSVDPSAGAVTTMEHHVLHVHGADKHAATTEIAARDGRVLMFLDTKHAVDRLTDHLLNSGVRAAALHGGKSQSQRTRTLAQFKTGHVTVLVATNVAARGIHVDNLDLVVNVDPPSDHKDYLHRGGRTARAGESGSVVTLVTPNQRRAMTRLMTTAGIVPQTTPVRSGTEALHRVTGAQAPSGIPVVVTAPVAERAERGATSRGRRRPAPATRRGSVRRSVTDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0W1</accession>
    <name>Q9L0W1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3743</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627934.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029203.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3743"/>
    <dbReference type="GeneID" id="1099179"/>
    <dbReference type="KEGG" id="sco:SCO3743"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3804"/>
    <dbReference type="eggNOG" id="COG3222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075662_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0W1"/>
    <dbReference type="OMA" id="CDAWFGP"/>
    <dbReference type="PhylomeDB" id="Q9L0W1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="22145" checksum="545C5723639B10B8" modified="2000-10-01" version="1">MSMVNTLLVIAKEPRPGRVKTRLTPPFTPVEAAALAEAALADTLAVVAAAPARRRVLVLDGAPGPWLPPGFDVVPQCAGGLDARLADAFAGCTGPALLIGMDTPQVTPGLLDVDFRDCDAYFGPAEDGGFWALGLARPEPALLRGVPMSTPVTGAVQRERLLAAGLRVRDLPPLRDVDTAADARTVAALAPDGRFAARLAACAPAADRRRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1E6</accession>
    <name>Q9L1E6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enoyl-coA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5459</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629596.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030262.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5459"/>
    <dbReference type="GeneID" id="1100899"/>
    <dbReference type="KEGG" id="sco:SCO5459"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5543"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_11"/>
    <dbReference type="InParanoid" id="Q9L1E6"/>
    <dbReference type="OMA" id="AMEMIMT"/>
    <dbReference type="PhylomeDB" id="Q9L1E6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="27136" checksum="C7CC89F02EA03C83" modified="2000-10-01" version="1">MTVHLEVAEGVGTLRLDRPPMNALDVATQDRLKELAEEITRREDVRAVVIHGGEKVFAAGADIKEMQVMDHAAMIARSCALQDSFTAVARIPKPVVAAVTGYALGGGCELALCADFRIAGENAKLGQPEILLGLIPGAGGTQRLSRLIGPSKAKDLIFTGRQVKADEALALGLVDRVVPAAEVYEQAHAWAARLAKGPAIALRAAKEAIDTGLETDIETGLAVERNWFAGLFATEDRERGMRSFVEEGPGKATFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1J1</accession>
    <name>Q9L1J1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonic acid semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2726</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626959.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028544.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2726"/>
    <dbReference type="GeneID" id="1098160"/>
    <dbReference type="KEGG" id="sco:SCO2726"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2782"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_10_11"/>
    <dbReference type="InParanoid" id="Q9L1J1"/>
    <dbReference type="OMA" id="HIYGNDG"/>
    <dbReference type="PhylomeDB" id="Q9L1J1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018478">
        <property type="term" value="F:malonate-semialdehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="500" mass="52573" checksum="089F3B4AC57F6C19" modified="2000-10-01" version="1">MTNIVNHWIGGKTAEGASGTYGPVTNPATGEVTTKVAFASVDEVDAAVAAAREAYLTWGQSSLAQRTSILFRFRALLDAHRDEIAELITAEHGKVHSDALGEVARGLEIVDLACGINVQLKGELSTQVATRVDVSSIRQPLGVVAGITPFNFPAMVPLWMFPIAIACGNTFVLKPSEKDPSAAVKVAELLSEAGLPDGVFNVVHGDKVAVDRLLEHPDVKAVSFVGSTPIARYIHTTASANGKRVQALGGAKNHMLVLPDADLDAAADAAVSAAYGSAGERCMAISAVVAVGAVGDELVEKIRERAEKIKIGPGTDPSSEMGPLITKAHRDKVASYVAGAAAEGCEVVLDGTGYTVDGHEDGHWIGISLLDRVPTTAKAYQDEIFGPVLCVLRADTYEEGVALINASPFGNGTAIFTRDGGAARRFQLEIEAGMVGVNVPIPVPVGYHSFGGWKDSLFGDHHIYGNDGTHFYTRGKVVTTRWPDPADAPAGVDLGFPRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1M5</accession>
    <name>Q9L1M5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630960.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031275.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6890"/>
    <dbReference type="GeneID" id="1102329"/>
    <dbReference type="KEGG" id="sco:SCO6890"/>
    <dbReference type="eggNOG" id="ENOG5031N5A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748575_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176827" evidence="1">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="149" mass="15634" checksum="094F5F323BDD0CE4" modified="2000-10-01" version="1">MRSTRVAISAAMLGALALSALSATPASAATVPTATPAVSCHNLPPLPYAVHTKAVIIRSRASSKSTALGVLYKSHKFSVSKKSGTWLSITDQDDRRQGLGLRHVCLPRCPLVPGLTGSSTSRQAAGVPSKAAVRIPQAFAFREQEIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L205</accession>
    <name>Q9L205_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO2628</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626864.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028463.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2628"/>
    <dbReference type="GeneID" id="1098062"/>
    <dbReference type="KEGG" id="sco:SCO2628"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2674"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_9_2_11"/>
    <dbReference type="InParanoid" id="Q9L205"/>
    <dbReference type="OMA" id="WEGGVHL"/>
    <dbReference type="PhylomeDB" id="Q9L205"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="32"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB71803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="422" mass="44001" checksum="D2F34DBE8CE863F6" modified="2000-10-01" version="1">MTSQPTLTKPEEGPAGPSGPDTGLQAGLKNRHLSMIAIGGVIGAGLFVGSSSGIATAGPGILLSYALVGTLVVLVMRMLGEMSAANPTSGSFSAHADRALGPWAGFSIGWLYWFFWVVVLAVEATAGAKILEGWIPAVPQWGWALIVMVVLTATNLASVGSYGEFEFWFAGIKVVAIAAFIVVGGLAVFGVLPGVDSDRAGLGNLTEHGGFLPHGAGAVLTGVLLVVFSFMGSEIPTLAAGESEDPQRAVTKATNSIIWRIAVFYLGSIFVVVALLPWDSQSIVDQGSYVAALDSLGIPNAGEIMNFIVLTSVLSCLNSGLYTASRMAFSLGRRGDAPKAFARTTRRGVPQAAILSSVVFGFVAVFFNYKFPDTVFLFLLNSSGAVASSSGWPSASRSCGCGRSSRPRRRRSWSCGCGCTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L218</accession>
    <name>Q9L218_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport protein ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6814</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630886.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6814"/>
    <dbReference type="GeneID" id="1102253"/>
    <dbReference type="KEGG" id="sco:SCO6814"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6923"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9L218"/>
    <dbReference type="OMA" id="ICENICM"/>
    <dbReference type="PhylomeDB" id="Q9L218"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB71261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="23913" checksum="D063FF42213A8684" modified="2000-10-01" version="1">MRELRVRSRDKNLVGPVSFSLKHGSTTGLCGPSGVGKSTVLRALVELLPNGLTRDGELQVLDRTIAPGKGDADLRSKIVLVPQTPVVFGGSILDNALFGLRHLLRASQEVLRERAEKALEEAGLWKEVADRLDSPAQNLSAGQRQRLCLARALALEPAGLLLDEPTSALDERSRDKVEQSISALRGSRAVLLVSHDPAQVERLCDTTVHLDQPVTASTPAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2F6</accession>
    <name>Q9L2F6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2527</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB69748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626767.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028407.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2527"/>
    <dbReference type="GeneID" id="1097961"/>
    <dbReference type="KEGG" id="sco:SCO2527"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2572"/>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1189365_0_0_11"/>
    <dbReference type="OMA" id="CGGDRNY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="101"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB69748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="231" mass="24240" checksum="18989429A81DEF26" modified="2000-10-01" version="1">MLPGRGPNGRAARLPRILGTRTAWTPVGDGEFFCPGCGGDRNYTRLTGRRRFTLLGVPVLPRGESAPTVECAACRRHYGTDVLDHPTTTRFSAMLRDAVHTVALAVLTAGGTCSRTSLETATVAVRAAGFEDCTEEQLNALVEALEADTGRVRGEPCVPGLAIELHEALDPLAPHLAAVGRESILLQGARIALADGPYTPAERDALATVGAALTICSDDVTRLLESAGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2H1</accession>
    <name>Q9L2H1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626752.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028396.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2512"/>
    <dbReference type="GeneID" id="1097946"/>
    <dbReference type="KEGG" id="sco:SCO2512"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2557"/>
    <dbReference type="eggNOG" id="ENOG5031WT6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173373_2_0_11"/>
    <dbReference type="OMA" id="SCAGNEP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="68" mass="7138" checksum="3B11EE0B1D182E36" modified="2000-10-01" version="1">MEARHSALCVEGAEDTVKELRAALAEAGIVLPSLGLDPVSLAREAPCPLIELGRCSVETAQRLAAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD77</accession>
    <name>Q9RD77_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625101.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027364.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0800"/>
    <dbReference type="GeneID" id="1096223"/>
    <dbReference type="KEGG" id="sco:SCO0800"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.792"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_0_11"/>
    <dbReference type="InParanoid" id="Q9RD77"/>
    <dbReference type="OMA" id="RGWLAFT"/>
    <dbReference type="PhylomeDB" id="Q9RD77"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="205" mass="23066" checksum="E8B82329FFF445F1" modified="2000-05-01" version="1">MRGMAANQGERIRRRLSTGERREQLLSVGARLFSESPYDEVWIEQVAEIAGVSRGLLYHYFPNKRDFFAAVVERESERMLRMTAAVPGVPVREQLTAGLDAYLEYVRAHAHGYRAFHRADAAGDRAVRRVYQKALAAQERQILAALAADPEFGPAFEERGDVRLAVRGWLAFTTAVCLEWLRDPEPAREQVRDLCARALLGAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDA8</accession>
    <name>Q9RDA8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2843</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627072.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975956.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2843"/>
    <dbReference type="GeneID" id="1098277"/>
    <dbReference type="KEGG" id="sco:SCO2843"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2902"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RDA8"/>
    <dbReference type="OMA" id="MDGVLIH"/>
    <dbReference type="PhylomeDB" id="Q9RDA8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="28059" checksum="997D2583D4F7835A" modified="2000-05-01" version="1">MADRKPIESWLTDMDGVLIHEGVPIPGADAFIKRLRDSGKPFLVLTNNSIYTPRDLHARLRRMGLEVPIESIWTSALATAQFLEDQRPGGSAYVIGEAGLTTALHDIGYILTDHDPDYVVLGETRTYSFEAMTKAVRLINAGARFICTNPDETGPSTEGPLPATGAVAALITKATGKQPYFAGKPNPLMMRTGLNAIGAHSETSAMIGDRMDTDVLAGMEAGMQTFLVLTGLTRPEQVENFPYRPSQVVDSIADLVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDC0</accession>
    <name>Q9RDC0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable amino acid ABC transporter protein, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2831</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627060.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975969.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2831"/>
    <dbReference type="GeneID" id="1098265"/>
    <dbReference type="KEGG" id="sco:SCO2831"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2889"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9RDC0"/>
    <dbReference type="OMA" id="FQAYHLF"/>
    <dbReference type="PhylomeDB" id="Q9RDC0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014343">
        <property type="entry name" value="Ectoine_EhuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03005">
        <property type="entry name" value="ectoine_ehuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB65561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="261" mass="28788" checksum="A5BD363A5A815EB1" modified="2000-05-01" version="1">MPTDTLPNPEKSPERSSGELIRLEQVTKRFGDNTVLDHLDFSVDAGKHVTLIGPSGSGKTTILRLLMTLLKPDEGTITVDGQKLFPATEKERREVRKQIGMVFQQFNLFPNMSVLRNITEAPVTVLGMPKDEAVERAKGLLDMVGLADKCDARPAQLSGGQQQRVAIARALAMRPKVLLLDEVTSALDPELVAGVLDLLRDIARSTDITMLCVTHEMNFARDISDQVLMFDSGRVIEAGAPEKIFSEPEHDRTREFLSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDI5</accession>
    <name>Q9RDI5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2742</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626973.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028554.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2742"/>
    <dbReference type="GeneID" id="1098176"/>
    <dbReference type="KEGG" id="sco:SCO2742"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2798"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_11"/>
    <dbReference type="InParanoid" id="Q9RDI5"/>
    <dbReference type="OMA" id="CYRMTGV"/>
    <dbReference type="PhylomeDB" id="Q9RDI5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="127"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB66281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="34777" checksum="BD5E3112AC226766" modified="2000-05-01" version="1">MHETPPEPNEREKLVTSENSGRERDGATEAFVTHRNLLFTVAYEMLGSAADAEDVLQETWLKWAGVDLDTVRDRRAYLVRITTRQALNRLRTLGRRKESYVGSWLPEPLLTTPDVAEDVELADSVSMAMMLVMETLAPTERAVFVLREVFDLGYDEIAEAVEKSPAAVRQIAHRARAHVAARRPRGAVSATESREALAAFQRAVETGDLQGLLDILSPDVVLLGDGGGIKQAVLRPVVGADKVARLMLGGLVKLDMEMRMDPAQVNGHPALVIRLDGELDTVVAVRLDEGRITGLYAVRNPEKLSYMREEASLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ0</accession>
    <name>Q9RDJ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626967.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028551.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2735"/>
    <dbReference type="GeneID" id="1098169"/>
    <dbReference type="KEGG" id="sco:SCO2735"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2791"/>
    <dbReference type="eggNOG" id="ENOG5033I16">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136033_0_0_11"/>
    <dbReference type="OMA" id="ERPIKDN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="16247" checksum="6AC5F1ED23365FF4" modified="2000-05-01" version="1">MQNTTSGPALIAVAVVGLVVRQQLRTRPVRRTGSLIAPVVLGVLGVAGLAFGIASVDEHHPLTVPAVVLLVASLAVAASFGAARARTVQIWRGSGSEVLRKGTAATTGLWIASAATHIGLALWTDRAAGAGLLGAASLYAYLAIGLGTQNLLVRRRAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI33</accession>
    <name>Q9RI33_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0215</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37044">
        <property type="entry name" value="T37044"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624548.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026931.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0215"/>
    <dbReference type="GeneID" id="1095639"/>
    <dbReference type="KEGG" id="sco:SCO0215"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.186"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RI33"/>
    <dbReference type="OMA" id="GRIPMRD"/>
    <dbReference type="PhylomeDB" id="Q9RI33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="37206" checksum="34552C4A5458422F" modified="2000-05-01" version="1">MSTYSPRVDAAALETVLDAAVAAPSIHNTQPWRFRVETATGLLQVRADRTRVLPLADPRRRAQYLSVGAAVLNLRVAAAHMGWEPVVRLLPDPHDADLLAEVRPTGSGGNPPDYRWLYPSVERRHTSRLPFTGRPVPEHVVAEMTAAAQSEGARLYVPDIVSTWRLLEPIAVAETRNRTSSGRITETRHWLTAPGTVSPYGIPLTALGPQDLSGRIPMRDFSGPLPVPHPPARRFERHAQVALLWTAHDRPQDWLRAGQALERVLLTATARGVRTSMLHQAMEWPDLRAAARLPQQRCNPQILIRFGYGPEGGQAPRARVPEPDRPSARPRERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY1</accession>
    <name>Q9RIY1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36966">
        <property type="entry name" value="T36966"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624520.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026908.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0184"/>
    <dbReference type="GeneID" id="1095608"/>
    <dbReference type="KEGG" id="sco:SCO0184"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.157"/>
    <dbReference type="eggNOG" id="COG3046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031632_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RIY1"/>
    <dbReference type="OMA" id="GMSQYAD"/>
    <dbReference type="PhylomeDB" id="Q9RIY1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007357">
        <property type="entry name" value="PhrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04244">
        <property type="entry name" value="DPRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="604" mass="68234" checksum="94450B691F008FD3" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJZ2</accession>
    <name>Q9RJZ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625468.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027632.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1178"/>
    <dbReference type="GeneID" id="1096601"/>
    <dbReference type="KEGG" id="sco:SCO1178"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1177"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129336_2_0_11"/>
    <dbReference type="OMA" id="WLLHACQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="149" mass="16401" checksum="684BCE7B4969B7BD" modified="2000-05-01" version="1">MNTQGSPMEAGTQSTQSTQSIDGIDGIEAIERVVATVERTQRDKDAEGFLTLFRPDALWTTGHGKVLLGLDAIAEFTRAVLPQAVWDGDVTYEVIHTQFLRPDVAAVKVRQVYHSAEGETEGAPLYVMTKQEDGRWLLHACQNTEVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKB0</accession>
    <name>Q9RKB0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3177</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627393.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975639.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3177"/>
    <dbReference type="GeneID" id="1098611"/>
    <dbReference type="KEGG" id="sco:SCO3177"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3237"/>
    <dbReference type="eggNOG" id="ENOG5033M63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049032_0_0_11"/>
    <dbReference type="OMA" id="WVDQQRE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="422" mass="45609" checksum="73494FBB9C6A4832" modified="2000-05-01" version="1">MSSSGLIYAVIVGAWAAYLVPMWLRRQDELNEARPTERFSTAIRLLSGRAGMERRYAKDLRSRPADEAGPDADAPDAVTDSVDVRAFAVSRTRRHTRPTPPRQAAERPETARPRAGGPEDGPRPGQSAEPGRQAGTGAAPARERVPQARRAPVSPGAAARARRSKALARRRRTTVMLFLAFTLGSVVAAVGGLAFLWAPGVPAVLLSAYIAHLRAQERRRFAFQMDRRQAEAAAQRLRDRDPRPRRRGPAPAAPGTVGDLDAEEPDDGPETESGAGMSALAADRRALVEQTDHAEWVDQQRERRGRPQGDSWDPVPVPLPTYVTAPVAPRATPDVDLAAPDAWSSARSSAVAPDQEDAARASGADRDRPADAPAHAPAEERPEAPARSGARRAASARRARERGRTPLFDQYDDGDRPRAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKY4</accession>
    <name>Q9RKY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1425</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625707.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977400.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1425"/>
    <dbReference type="GeneID" id="1096851"/>
    <dbReference type="KEGG" id="sco:SCO1425"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1435"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="InParanoid" id="Q9RKY4"/>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="PhylomeDB" id="Q9RKY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="165" mass="17899" checksum="8D2798DAEE66D323" modified="2000-05-01" version="1">MTRTAQVSEEVNGTVGSCAMEELDRQIVQLLVKDGRMSYTDLGKATGLSTSAVHQRVRRLEQRGVIRGYAAVVDPEAVGLPMTAFISVKPFDPSAPDDIADRLAGVPEIEACHSVAGDENYILKVRVATPHELEELLARVRSLAGVSTRTTVVLSTPYESRPPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL29</accession>
    <name>Q9RL29_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0458</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624778.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027130.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0458"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095881"/>
    <dbReference type="KEGG" id="sco:SCO0458"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.436"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RL29"/>
    <dbReference type="OMA" id="HFAGQGA"/>
    <dbReference type="PhylomeDB" id="Q9RL29"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="674"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="762" mass="79693" checksum="55FCBE237A11BB4C" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2G2</accession>
    <name>Q9S2G2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2919</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36142">
        <property type="entry name" value="T36142"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627145.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975892.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2919"/>
    <dbReference type="GeneID" id="1098352"/>
    <dbReference type="KEGG" id="sco:SCO2919"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2977"/>
    <dbReference type="eggNOG" id="ENOG5034A2I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151347_0_0_11"/>
    <dbReference type="OMA" id="HPDGLIW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176971" evidence="1">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="12064" checksum="534AF9344756F48B" modified="2000-05-01" version="1">MAAGGFCKLPNGTVVVALNLPSPAPASAGSVRFLVHAQNRARALTRLRNLGLRSVYLRGNAAPPTPDEITAVLHHPDGLIWRTAPVAGAVGGPDLVQELWHPIRALLRRPTAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2I5</accession>
    <name>Q9S2I5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SCO2018</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35763">
        <property type="entry name" value="T35763"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626279.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028099.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2018"/>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="GeneID" id="1097452"/>
    <dbReference type="KEGG" id="sco:SCO2018"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2048"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="InParanoid" id="Q9S2I5"/>
    <dbReference type="OMA" id="EGMHRFT"/>
    <dbReference type="PhylomeDB" id="Q9S2I5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="228"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="515"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAB52074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="835" mass="92403" checksum="D2746657BCF2D5BB" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2L3</accession>
    <name>Q9S2L3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO1990</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35735">
        <property type="entry name" value="T35735"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626251.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976828.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1990"/>
    <dbReference type="GeneID" id="1097424"/>
    <dbReference type="KEGG" id="sco:SCO1990"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2017"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2L3"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="PhylomeDB" id="Q9S2L3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="48"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB52046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="25634" checksum="5F48009B85129821" modified="2000-05-01" version="1">MDTGGLSVLDRRIEGCRACPRLVEWREEVARTKRAAFADWTYWGRPVPGFGPPDARLLIVGLAPAAHGGNRTGRMFTGDRSGDVLYQALYDVGLASQPTAVRVDDGLELYGVRVTSPVHCAPPANKPTPAERDTCRSWLVQELGLLRPTLRAVVVLGAFGWQAALPAFAGAGWTVPRPRPAFAHGTQVTLDAADGPDLHLFGCFHVSQRNTFTGRLTPEMLRDVLRTAAETAGLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X810</accession>
    <name>Q9X810_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35534">
        <property type="entry name" value="T35534"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626408.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976663.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2152"/>
    <dbReference type="GeneID" id="1097586"/>
    <dbReference type="KEGG" id="sco:SCO2152"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2187"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127113_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X810"/>
    <dbReference type="OMA" id="AWLASWS"/>
    <dbReference type="PhylomeDB" id="Q9X810"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14346" checksum="55BE1185B04DC61A" modified="1999-11-01" version="1">MQATATVLVYSDDSNTREQVRLATGRRPAPDVPVVEFVECATPAAVLKELDRGGIDVCVLDGEAVPMGGMGMCRQIKDEVFQCPPVLLLIARPQDAWLATWSRAEAAVTLPVEPVEFASALAALLREKRLQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X867</accession>
    <name>Q9X867_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3511</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36094">
        <property type="entry name" value="T36094"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627711.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029047.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3511"/>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="GeneID" id="1098947"/>
    <dbReference type="KEGG" id="sco:SCO3511"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3569"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055280_1_0_11"/>
    <dbReference type="OMA" id="GQLGTPY"/>
    <dbReference type="PhylomeDB" id="Q9X867"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177017" evidence="3">
        <location>
            <begin position="34"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="253"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB41210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="381" mass="38673" checksum="C13D189F1BD6A5DD" modified="1999-11-01" version="1">MKKTTGALVGLCATGPLLLALPILGIGAGTASASCSTDGAQGVDASAVAKQVKTILDGGDRGSVSVPGLDAPADQVPNAKTIQATGVAMNLPARGQAVALATALQESGLRNLTYGDRDSLGLFQQRPSMGWGTASQILDPVHASTKFYEGLKKVSGWQSLSVTQAAQAVQKSGFPEAYAKWEPLATALQKAIEPLLQEAGGASPSPSPSGSADTGSPSPDSAGGCSADGDGTDFGTIPAGALPDEYKIPASAPPKVQTAIRWALGQLGSPYQWGGTCTDSHGKNPMGRCDCSSLMQGAYKAAGVTLTRTTYTQVKDGKAVSVAALKPGDLLFTEGTAAVPEHVGMAIGQGLIVHAPHTGDVVRITTVASWKSRILAARRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8A6</accession>
    <name>Q9X8A6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36171">
        <property type="entry name" value="T36171"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627730.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029066.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3530"/>
    <dbReference type="GeneID" id="1098966"/>
    <dbReference type="KEGG" id="sco:SCO3530"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3587"/>
    <dbReference type="eggNOG" id="ENOG50340F3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103362_0_0_11"/>
    <dbReference type="OMA" id="GPFAACT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="21347" checksum="938A7F26C6069EE8" modified="1999-11-01" version="1">MADTSPTSPGPEPYRVPDADLDDLASTLAKTMAEVRQHGVILDRLGSEPDPGAIQPPDGAPEAEAADGKKPDGPASVFILALGGKEYAVELAALSDWVNYLFLPVYGREISTSRPWCAHWHEHPEAVARLHALWLAWQQFTDTEAGLSGPSIWHRDHLDQTLAHLRAPDGPFAACTTSATRPNHRVLATPAPEQAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="145" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G8</accession>
    <name>Q9X8G8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3344</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36293">
        <property type="entry name" value="T36293"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627553.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028924.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3344"/>
    <dbReference type="GeneID" id="1098781"/>
    <dbReference type="KEGG" id="sco:SCO3344"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3406"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_1_11"/>
    <dbReference type="InParanoid" id="Q9X8G8"/>
    <dbReference type="OMA" id="DTQAFIP"/>
    <dbReference type="PhylomeDB" id="Q9X8G8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="720" mass="75444" checksum="86127439E6EBE0F5" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8L7</accession>
    <name>Q9X8L7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3353</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36364">
        <property type="entry name" value="T36364"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627561.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028929.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3353"/>
    <dbReference type="GeneID" id="1098790"/>
    <dbReference type="KEGG" id="sco:SCO3353"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3416"/>
    <dbReference type="eggNOG" id="ENOG503304R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1772188_0_0_11"/>
    <dbReference type="OMA" id="ITHTVEW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB40853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13316" checksum="F5155D9884B92774" modified="1999-11-01" version="1">MKFSLRSVRNSYSPGQTPAFELTARNTSGGDCEVDLGPKHAVFTITPASGDDAYWASDDCVEGAGSLRYRVTAGSGITYTVKWDRKPSAPECGTPPAGSAKAGTYLVEAKAAGFEKVQTSFVLKND</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8R9</accession>
    <name>Q9X8R9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3652</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36542">
        <property type="entry name" value="T36542"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627846.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029145.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3652"/>
    <dbReference type="GeneID" id="1099088"/>
    <dbReference type="KEGG" id="sco:SCO3652"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3712"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043666_0_0_11"/>
    <dbReference type="OMA" id="HARRTMI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="310" mass="31700" checksum="12B7120C54C91126" modified="1999-11-01" version="1">MPTGGAPGRRWVGCRDMEHEVFVPVPAERLRDVLADPVRVARAVPGLQQDAGAEPVAGRLKVRIGSHSITYRGSLRLSARGDGTYAVEGDATESRGTGAVALALTLRADDAEGGATLTFTGTATADGRVAELPPDSVASAANRLLARFAENLGTAAQAPPAPEPEPSPQPEPRPASVFDTEVPPSSLADSGGGSDSDSDGDADEDTDAGADADADAQADEKAEAEGDADRGGRTDDEPAVSPPAEAAHARRTMIGRSAEEVDHAPPRGRYAPVPAPQPSAVGAPLRWAAPAAALVVASAIVVGRALRKRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8U5</accession>
    <name>RL9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">SCO3909</name>
        <name type="ORF">SCH24.31</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36596">
        <property type="entry name" value="T36596"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628095.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975023.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8U5"/>
    <dbReference type="SMR" id="Q9X8U5"/>
    <dbReference type="STRING" id="100226.SCO3909"/>
    <dbReference type="GeneID" id="1099345"/>
    <dbReference type="KEGG" id="sco:SCO3909"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3983"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_5_1_11"/>
    <dbReference type="InParanoid" id="Q9X8U5"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="PhylomeDB" id="Q9X8U5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176685" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="148" mass="15968" checksum="95370135ADF78F07" modified="1999-11-01" version="1">MKIILTHEVSGLGAAGDVVDVKDGYARNYLIPRKFAIRWTKGGEKDVEQIRRARKIHEIQTIEQANQVKAQLEGVKVRLAVRSGDAGRLFGSVTPADVASAIKAAGGPEVDKRRIELGSPIKTLGAHETSVRLHPEVDAKVSIEVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W3</accession>
    <name>Q9X8W3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3681</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36616">
        <property type="entry name" value="T36616"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627873.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029161.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3681"/>
    <dbReference type="GeneID" id="1099117"/>
    <dbReference type="KEGG" id="sco:SCO3681"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3739"/>
    <dbReference type="eggNOG" id="ENOG50320RN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100184_2_0_11"/>
    <dbReference type="OMA" id="DGYHRQP"/>
    <dbReference type="PhylomeDB" id="Q9X8W3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="17455" checksum="17C7DA2C0F7892DC" modified="1999-11-01" version="1">MITALPTPPLPLPLVRLRLAPHGALPRRIDGVWWPHSRDLLTQLPKMLAALPSAWGDITGVTVDAAAWSAAPGRMFVATQVVRLHKAPASPHAPDRVVLLSPGLGRRDLQVIPPDATEEAAALLMAAALDDRRPGADGARPPTPTAAAGPHGRVGPAGRGTRAPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAG6</accession>
    <name>Q9XAG6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35604">
        <property type="entry name" value="T35604"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629467.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030175.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1100765"/>
    <dbReference type="KEGG" id="sco:SCO5325"/>
    <dbReference type="HOGENOM" id="CLU_2221648_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="106" mass="11671" checksum="3E937043AEF27501" modified="1999-11-01" version="1">MEITLAALQGRWTTLVIRELLRGDHSYSDLRAALAAPSDKVTKVAADVITRWSSARARASQPVTARSRRTALASPPPSRTRAPPGTAGDRLTSPRPRRVRARPRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ3</accession>
    <name>Q9XAQ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NLP/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4561</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34625">
        <property type="entry name" value="T34625"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029732.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4561"/>
    <dbReference type="GeneID" id="1100001"/>
    <dbReference type="KEGG" id="sco:SCO4561"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4633"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019086_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAQ3"/>
    <dbReference type="OMA" id="ILYWGSA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177051" evidence="3">
        <location>
            <begin position="46"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="160"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="27694" checksum="C53669505187B256" modified="1999-11-01" version="1">MSHTAHIRSHRKPRRSASTIAMRTGVAGGVLSTLAVAGASGAAHAAEPVTQTLELPTLTADLAAQVAQSADVTQQAAASYQLQAERDAAAAKAAKQAKTDLAEAKKKAAEAKKKAEEAARKEAAERASRAAERTTLSASSDTGSSTGTGSSTSTGTSTATGSAAAVVSFVQAQVGKAYVSGATGPSAYDCSGLVQAAFKQVGISLPRVSQAQSTAGTQVGLDNLQPGDILYWGGAGSAYHVGVYVGGGMFVGAQNSSTGVVEKPLSYDPPSGAVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAS1</accession>
    <name>Q9XAS1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4579</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34607">
        <property type="entry name" value="T34607"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628741.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029742.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4579"/>
    <dbReference type="GeneID" id="1100019"/>
    <dbReference type="KEGG" id="sco:SCO4579"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4651"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056335_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAS1"/>
    <dbReference type="OMA" id="DEYPDAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177052" evidence="8">
        <location>
            <begin position="16"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="312" mass="33758" checksum="76EB29C2C310239A" modified="1999-11-01" version="1">MTVCLLLLFVVAVTAAVPVPRALTRSAWPERDPVVGLWVWQCLVATVLLCCLTALTLGATAVFGTVRAQLFAPAPPAVTAAYNLSAGPVWAAALTLLLAAGAAWTTAMLARELVEARRRRARSRAHLRERAPDLPAGLPAARGPLLVLEDEYPDAWWMPGSPPQLIVTTGALHRLTDHQLDAVLTHERGHARARHDWLLHLSTALATGFPSVPLFAHFCDQTHRLVELSADDTASRRCGHLTTALALIELNQHRGVLSCASSHRLLGERVDRLLEPRPRLPRRHRALTTATAALVPLIPLLITFAPGLTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Z1</accession>
    <name>Q9Z4Z1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3240</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36188">
        <property type="entry name" value="T36188"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627452.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028850.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3240"/>
    <dbReference type="GeneID" id="1098674"/>
    <dbReference type="KEGG" id="sco:SCO3240"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3304"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077963_1_0_11"/>
    <dbReference type="OMA" id="WVEDACA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="236" mass="23972" checksum="4D9F0C52B8F62800" modified="1999-05-01" version="1">MNPGGDGPRSLPDALAGALDRALAPDAAAWLEQACAAVRCEPGEVEGTFAVAARRCGRGALDAGAEAGAGADAGTGLGAGWSVDDAARVLLLAALPVRGAALAAVVSRLYRIGGGPERRAVLRSLSLLEAAGDLGDLGLPLVEDALRCNDPRLIAAAVGPYGARRLGAHAFRQAVLKCVFVGVPLDLVAALDARADAELDRMMADFAAERRAAGRALPPDVAAYLHTHRVSTEATA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z528</accession>
    <name>TRUB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">SCO5709</name>
        <name type="ORF">SC9F2.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35986">
        <property type="entry name" value="T35986"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629836.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030403.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z528"/>
    <dbReference type="SMR" id="Q9Z528"/>
    <dbReference type="STRING" id="100226.SCO5709"/>
    <dbReference type="GeneID" id="1101148"/>
    <dbReference type="KEGG" id="sco:SCO5709"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5798"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z528"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="PhylomeDB" id="Q9Z528"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000121913" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="301" mass="31998" checksum="2E5906475E7D575F" modified="1999-05-01" version="1">MTEKHTTPDGLVIVDKPSGFTSHDVVAKMRGIARTRRVGHAGTLDPMATGVLVLGVERATKLLGHLALTEKEYLGTIRLGQTTLTDDAEGEITGSRDASKVTWEAIDAGVAELSGDIMQVPSKVSAIKIKGVRSYKRAREGEEFEIPARPVTVSSFAVYDVRDAVADDGTPVLDLVVSVTCSSGTYIRALARDLGAGLGVGGHLTALRRTRVGPYKLDGARTLDQLQQELTVMPVADAAGAAFPRWGVDARRARLLANGVRLEMPEEYTGVGAVAVFDPEGRLLALVEEHKGKAKSLAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z546</accession>
    <name>Q9Z546_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6126</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35909">
        <property type="entry name" value="T35909"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630232.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972795.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101567"/>
    <dbReference type="KEGG" id="sco:SCO6126"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6230"/>
    <dbReference type="eggNOG" id="ENOG5031SRD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2119778_0_0_11"/>
    <dbReference type="OMA" id="DLACAYA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="104" mass="11194" checksum="0CB04D93BFC0765B" modified="1999-05-01" version="1">MTDAPVRIAEADGQHAVLAFSGDLDAPALVVLEELLLDPRLREPRAWTLEMSGLDHIDLACAYALLRTVTRAPEPVALTIRGARPAVHRTLRQAGLDTVAAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBX3</accession>
    <name>Q9ZBX3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3959</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22231.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36065">
        <property type="entry name" value="T36065"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628143.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974984.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3959"/>
    <dbReference type="TCDB" id="3.A.1.146.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099395"/>
    <dbReference type="KEGG" id="sco:SCO3959"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4031"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099045_0_0_11"/>
    <dbReference type="OMA" id="ATWYAGQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA22231.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="24774" checksum="7316E5C3F0E124E3" modified="2002-10-01" version="2">MYDPTVARLTYRALLGRRRALILGVLPLLLLVIAVAVRALAGADDQTSVDVLGGFALATMVPIIGVIAGTGAIGPEIDDGSVVYLLSKPIKRPTIIFTKLIVAIAVTMVFSAVPTLLAGLILNGNGQQVAVAYTIAALVASIAYAALFLLLGTVSRHAVVFGLVYALVWEALFGSLVPGARTLSVQQWSLAVAQKVADGNLVTSDVGLPTATVLLAAVTVLATWYAGQKLRSLTLAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZC17</accession>
    <name>Q9ZC17_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6496</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34726">
        <property type="entry name" value="T34726"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630578.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030965.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6496"/>
    <dbReference type="GeneID" id="1101935"/>
    <dbReference type="KEGG" id="sco:SCO6496"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6597"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_11"/>
    <dbReference type="InParanoid" id="Q9ZC17"/>
    <dbReference type="OMA" id="ISDHHIR"/>
    <dbReference type="PhylomeDB" id="Q9ZC17"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="629" mass="65685" checksum="24BD5FB925F26F37" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-09-18" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O50500</accession>
    <name>NGCF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diacetylchitobiose uptake system permease protein NgcF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ngcF</name>
        <name evidence="8" type="ordered locus">SCO6006</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2018" name="Microbes Environ." volume="33" first="272" last="281">
            <title>NgcESco acts as a lower-affinity binding protein of an ABC transporter for the uptake of N,N'-diacetylchitobiose in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Iinuma C."/>
                <person name="Saito A."/>
                <person name="Ohnuma T."/>
                <person name="Tenconi E."/>
                <person name="Rosu A."/>
                <person name="Colson S."/>
                <person name="Mizutani Y."/>
                <person name="Liu F."/>
                <person name="Swiatek-Polatynska M."/>
                <person name="van Wezel G.P."/>
                <person name="Rigali S."/>
                <person name="Fujii T."/>
                <person name="Miyashita K."/>
            </authorList>
            <dbReference type="PubMed" id="30089751"/>
            <dbReference type="DOI" id="10.1264/jsme2.ME17172"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the ABC transporter complex NgcEFG-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of two ATP-binding proteins (MsiK), two transmembrane proteins (NgcF and NgcG) and a solute-binding protein (NgcE).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Constitutively expressed. Slightly induced by GlcNAc, (GlcNAc)2 and chitin. Repressed by DasR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35671">
        <property type="entry name" value="T35671"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630120.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030592.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50500"/>
    <dbReference type="SMR" id="O50500"/>
    <dbReference type="STRING" id="100226.SCO6006"/>
    <dbReference type="GeneID" id="1101448"/>
    <dbReference type="KEGG" id="sco:SCO6006"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6104"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="OMA" id="AYQIVYF"/>
    <dbReference type="PhylomeDB" id="O50500"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000447876" description="Diacetylchitobiose uptake system permease protein NgcF">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="2">
        <location>
            <begin position="95"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="30089751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="30089751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="30089751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="CAA15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="353" mass="38014" checksum="D9818A86A42F8B57" modified="1998-06-01" version="1">MKDTIPTAETASRRPEPAARGGRPRRRKLTFDRVTFFLAFLGVPLAIFVIFVLIPFGQAIFWGMTDWRGFSPDYNFVGFDNFTKMFQDDIFLKALRNVALLAAFVPLVTLTLALGVAVAITLGGPSKGPVRGIRGASFYRIISFFPYVVPAIIVGLIWAQMYDPNAGLLNGVLTGLGLDQFDTFAWLGEKAAAMPAVMFVIVWGLVGFYAVLFIAAIKGVPGELYEAAKIDGAGRFRTTISITLPAIRDSVQTAYIYLGIAALDAFVYVQAMVPNGGPDNSTLTISQRLFNVAFAKQQFGYATAMGVVLAAVTLVFAALVFLVNRLTGGGEGESKRKAPGSRARRAAAKGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O69821</accession>
    <name>O69821_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6427</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28697">
        <property type="entry name" value="T28697"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030908.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6427"/>
    <dbReference type="GeneID" id="1101866"/>
    <dbReference type="KEGG" id="sco:SCO6427"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6527"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_11"/>
    <dbReference type="InParanoid" id="O69821"/>
    <dbReference type="OMA" id="TIWNQTI"/>
    <dbReference type="PhylomeDB" id="O69821"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="223"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA18914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="431" mass="44850" checksum="1D4F31D75E60CE14" modified="1998-08-01" version="1">MTSKLTALLPDLAPWRSSRDFRLLWVQGLVTYLGSVMALIALPLQIKELTGSPLAVGVMGAVELVPLVVFGLYGGALADAVDRRRVIVLTEAGLGLLAAVLLVNALLPHPLLWPLYVVAGGVAALAGLQRPALDSLLARIVPHDQLAAAAALNALRWQAGAIAGPALAGLVVAYAGNVPAYATTVVCFCASVLMCRGLSPVPPAEHAARPSLRGIAEGARYAWSRPVLLGTYAIDLAAMLFAFPNTIFPFLADELDADWALGLMYSAGAVGSLLVSLTSGWVSRTRRHGLLVVFGATGWGLAVAAAGWTSQIWLVLACLALAGAGDMLSGLGRTTIWNQTIPDRLRGRLAGIEVLSYSIGPQLGQVRAGAMAGWTGARPAIWTGGVACVAAVGLLTAALPRLVGYDARTDEDALRRAREGDGPRAEEPTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>O86681</accession>
    <name>O86681_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6634</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35043">
        <property type="entry name" value="T35043"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630710.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031060.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6634"/>
    <dbReference type="GeneID" id="1102073"/>
    <dbReference type="KEGG" id="sco:SCO6634"/>
    <dbReference type="HOGENOM" id="CLU_2902159_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="62" mass="6902" checksum="03956A18E736892A" modified="1998-11-01" version="1">MALYPRFDAIGRGIRRVTETYDLPFAVVTIRTCWTLPIGAMAAVARAVREAYGTGWGERVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>O86756</accession>
    <name>O86756_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5643</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35455">
        <property type="entry name" value="T35455"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629773.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030358.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5643"/>
    <dbReference type="GeneID" id="1101082"/>
    <dbReference type="KEGG" id="sco:SCO5643"/>
    <dbReference type="HOGENOM" id="CLU_1531666_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="175" mass="18571" checksum="9D8BB621E8004E16" modified="1998-11-01" version="1">MALWAYLVPAAGQERAGVGRCGHALGGQPDRPRHGLGPLSAAIVAVSAAGTGAGHVVDTVTCRSADHPYADERPDEGDGCHQFGCPWASAAVGRRWVNHYRATDTRDSGRGHAGRLALCCEKAGRAKGVRRTPTSATLRRSTVLRRHRTGLLDALLPVRCFTVVDSVKTSVLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK1</accession>
    <name>Q8CJK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7405</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAD55401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733732.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031638.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7405"/>
    <dbReference type="GeneID" id="1102843"/>
    <dbReference type="KEGG" id="sco:SCO7405"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7515"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_2_11"/>
    <dbReference type="InParanoid" id="Q8CJK1"/>
    <dbReference type="OMA" id="RIKFVEF"/>
    <dbReference type="PhylomeDB" id="Q8CJK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23178" checksum="00F7BAA5127B056B" modified="2003-03-01" version="1">MTTDPREREVRRRMAARELYSDGAPGLAALAEERLRGKELADAYNRTGARDEEGRRALLKEMLAALGTGVWIEPPLHVAYGNRVHLGDDVYANFGLTLVDDVEVFVGDRVMFAPHVTVSTTGHPVHPDLRRDGTQFSAPVRIEDDVWIGAGAQIMPGVTVGRGSVVGAGSVVTAHVPPMTVVAGTPARVLREITDADREWSYRPPRTLGPGPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL2</accession>
    <name>Q8CJL2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733721.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972111.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7034"/>
    <dbReference type="GeneID" id="1102472"/>
    <dbReference type="KEGG" id="sco:SCO7034"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7138"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_11"/>
    <dbReference type="InParanoid" id="Q8CJL2"/>
    <dbReference type="OMA" id="MVPNYNP"/>
    <dbReference type="PhylomeDB" id="Q8CJL2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003867">
        <property type="term" value="F:4-aminobutyrate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="422" mass="44496" checksum="E140CE462791879D" modified="2003-03-01" version="1">MTALSPHLRQATPVVAVRGEGVHIEGEDGRRYLDFTAGIGVTSTGHCHPRVVAAAQEQVATLVHGQYTTVMHPPLRRLVDKLGEVLPQSLDSLFFTNSGSEAVEAALRLARQATGRPNVLVCHGGFHGRTVAAASMTTSGTRFRSGFSPLMSGVVVTPFPTAFRYGWDEETATRFALQELDYTLQTISSPADTAAVIVEPVLGEGGYVPANRAFVEGLRERADRHGFLLILDEVQTGVGRTGRFWGHEHFGVAPDILVTAKGLASGFPLSAIAAPEELMRKAWAGSQGGTYGANAVACAAACATLDVVRDEKLVENAEAMGARLRHGLEAVASRNPAVGDVRGMGLMLASEFVTADGEPDPETAARVQRAAVDEGLLLLLCGAWNQVVRMIPALVIDETAVDEGLRAWAAAVEAGTSGAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL6</accession>
    <name>Q8CJL6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6895</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAD55391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733717.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031280.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6895"/>
    <dbReference type="GeneID" id="1102334"/>
    <dbReference type="KEGG" id="sco:SCO6895"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7004"/>
    <dbReference type="eggNOG" id="ENOG50318J8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601705_0_0_11"/>
    <dbReference type="OMA" id="VCEFSSR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD55391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18406" checksum="69339A684113DFDA" modified="2003-03-01" version="1">MSTPFTPAEAHRAIDVLASRSLIRLITEIDDNGAIPPRRLASTLPDLTPHRLRSASDTARAHSLVRVAPGAGLELTDSGMELADLYDALARWARRHSLPAAVCEFSSRIRHVLGLLTPSLTPGNADRPAPLPDAHPISAEAEADLARVRTLLIQWLAGNLQVARAEPERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJT7</accession>
    <name>Q8CJT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4458</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAD55484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733638.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029667.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4458"/>
    <dbReference type="GeneID" id="1099898"/>
    <dbReference type="KEGG" id="sco:SCO4458"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4528"/>
    <dbReference type="eggNOG" id="COG3544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074343_1_1_11"/>
    <dbReference type="InParanoid" id="Q8CJT7"/>
    <dbReference type="OMA" id="WANAVIK"/>
    <dbReference type="PhylomeDB" id="Q8CJT7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004307432" evidence="2">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="3">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="21701" checksum="0553DCE224027B3A" modified="2003-03-01" version="1">MRRTAVVAAAGAAALVLAACGGSGGDGSAGHGGHAATAPSSAPSSASASASASASQGQHNAADVAFAKGMIPHHRQAVEMADLAPGRARSAEVQKLAADIKKAQDPEIRTLSGWLTSWGEDVPAEGAMDHSTHDMSGMGGMMTAEEMTGLENASGKAFDTAFTELMIKHHEGAVEMARTEQADGAHGPARKMAVEIIDSQSAEIEQMNALLGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX4</accession>
    <name>Q8CJX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative penicillin acylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3184</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733595.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028816.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CJX4"/>
    <dbReference type="STRING" id="100226.SCO3184"/>
    <dbReference type="MEROPS" id="S45.003"/>
    <dbReference type="GeneID" id="1098618"/>
    <dbReference type="KEGG" id="sco:SCO3184"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3244"/>
    <dbReference type="eggNOG" id="COG2366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011790_0_1_11"/>
    <dbReference type="InParanoid" id="Q8CJX4"/>
    <dbReference type="OMA" id="EMDVRRH"/>
    <dbReference type="PhylomeDB" id="Q8CJX4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD55496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="936" mass="102511" checksum="A8310BB37AB9BDAA" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJY1</accession>
    <name>Q8CJY1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2942</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAD55459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733587.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975868.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2942"/>
    <dbReference type="GeneID" id="1098375"/>
    <dbReference type="KEGG" id="sco:SCO2942"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3000"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_2_0_11"/>
    <dbReference type="InParanoid" id="Q8CJY1"/>
    <dbReference type="OMA" id="EIRGWQY"/>
    <dbReference type="PhylomeDB" id="Q8CJY1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="306" mass="31160" checksum="2C383D32878CDF2E" modified="2003-03-01" version="1">MGQREGAVGLTTHAPQAAQAVTLPTTLDEAVAALTALPAAVPVAGGTDLMAAVNSGQLRPAALVGLGRISEIRGWQYQDGHALLGAGLTHARMGRPDFAALIPALAAAARAAGPPQIRNAGTLGGNIASAAPTGDALPVLAALEATLIIAGPDGARREMPVSHLLAGMEMLRAGELIGYVRVPLLHAPQVFLKATGRTGPGRATASVALVLDPARRGVRCAVGAIAPMPLRPLEAEQWVASLIDWDNGRAVVPEALHGFGEYVAAACIPDAVPDEDGSVPQLPPAVLHLRRTVAALARRALGRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IU7</accession>
    <name>Q93IU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5108</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629258.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030062.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5108"/>
    <dbReference type="GeneID" id="1100549"/>
    <dbReference type="KEGG" id="sco:SCO5108"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5190"/>
    <dbReference type="eggNOG" id="ENOG502Z8CG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000864_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IU7"/>
    <dbReference type="OMA" id="DRWWLAP"/>
    <dbReference type="PhylomeDB" id="Q93IU7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="278" mass="31617" checksum="F18CC7CA616AD19E" modified="2001-12-01" version="1">MATGTEPPATEDRPPGGGVHTPTRAAIRARHLRTDRWWLAPAATAAGLLAFVVYSTWRAFANADYYAAPYVSPFYSPCLAENCEPMRSGPNWELFGTWWGISPAIIILIFPLGFRLTCYYYRKAYYRGFWASPPACAVAEPHRKYTGETRFPLILQNVHRYFFYAALLVAGILSYDTVLAFRDEHYAWGHMGLGTLVFLANIALIWAYTLSCHSCRHIVGGKLKHFSRHPVRYRMWQLVGRLNARHMQLAWASLVSVALADFYVYLVASGVFDDPRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IY8</accession>
    <name>Q93IY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5097</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629247.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030055.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5097"/>
    <dbReference type="GeneID" id="1100538"/>
    <dbReference type="KEGG" id="sco:SCO5097"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5177"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_11"/>
    <dbReference type="InParanoid" id="Q93IY8"/>
    <dbReference type="OMA" id="GFITMPG"/>
    <dbReference type="PhylomeDB" id="Q93IY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="276" mass="28794" checksum="79077FEE78EA2728" modified="2001-12-01" version="1">MNKVWLITGASSGFGRAIAEAALADGDVVVGAARRPEALDDLVAAHPDQMEALRLDVADTAAAGDAVRDVVARHGRVDVLVNNAGRTHVGALEETGEDELRALFDVHVFGPAALTRAVLPSMRERRSGAIVQMSSMGGQMSFAGFSAYSGTKFALEGMSEGLADEVRDFGIKVLIVEPGSFRTGLFEAGNAGISADSGVYAKVGETRGMIAAGDGSQPGDPARAAAVIRAALAAEHTPLRLPLGDDGVTAVLGHLDRVREEVETWEKQTRATAFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J70</accession>
    <name>Q93J70_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2827</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627056.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028605.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2827"/>
    <dbReference type="GeneID" id="1098261"/>
    <dbReference type="KEGG" id="sco:SCO2827"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2885"/>
    <dbReference type="eggNOG" id="COG2164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618098_0_0_11"/>
    <dbReference type="OMA" id="YARNEIY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024532">
        <property type="entry name" value="DUF3830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12903">
        <property type="entry name" value="DUF3830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="18283" checksum="D45A53ADC4FFD453" modified="2001-12-01" version="1">MEGMADRYIEVSLVKRGITCTAQLLDDRAPITCAAVWDALPLGGDVYHAKYARNEIYALFPPFATSEPPLENPTVTPIPGDLCYFAFAGAELGTKAYGYDREVRPGTTLVDLALFYERNNLLLNGDVGWVPGTVWGRITEGLDTMAEACNDLWRTGAAGETLSFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JC0</accession>
    <name>Q93JC0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7476</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631523.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031686.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7476"/>
    <dbReference type="GeneID" id="1102914"/>
    <dbReference type="KEGG" id="sco:SCO7476"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7587"/>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038125_3_0_11"/>
    <dbReference type="InParanoid" id="Q93JC0"/>
    <dbReference type="OMA" id="WAGSSWP"/>
    <dbReference type="PhylomeDB" id="Q93JC0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176579" evidence="1">
        <location>
            <begin position="36"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="405" mass="44193" checksum="A1149C89363EF1FA" modified="2001-12-01" version="1">MSSAPPRRHRRSRAVLLATLTAALTGTLLTGPGSAISRADAAPAAFTHPGVTVSQGQLDFARAKVDAGAQPWKGAFDQMMASRYADLNRAPKPRAVVECGSYSNPDYGCTDEREDAIAAYTNALAWYFTRDERYARKSIELMDAWSAVLRDHTNSNAPLQTGWAGSSWPKAAEIIKYTYGGAWANSGRFATMLRDVYLPEIINGSNSNGNWELTMTEAAVGISVFLEDRASYDKAVARFRTRTAAYVYLNSDGELPKTVPSQHLDTRDKIVKYWQGQSTFVTGLTQETCRDFTHTGYGISSISHIAETSRIQGQDLYGTDVGERLRHALGFQAKYQQGAAVPSWLCGGKADLGLGPVTEVGYNALHNRLGFAMTNTQALTERTRPSGTNNLFVAWETLTHGDNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK6</accession>
    <name>Q93JK6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4988</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629140.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029988.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4988"/>
    <dbReference type="GeneID" id="1100429"/>
    <dbReference type="KEGG" id="sco:SCO4988"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5069"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_11"/>
    <dbReference type="InParanoid" id="Q93JK6"/>
    <dbReference type="OMA" id="DDEQLIW"/>
    <dbReference type="PhylomeDB" id="Q93JK6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="351" mass="36494" checksum="30E9D6D4F486F164" modified="2001-12-01" version="1">MTVDGPRSTAPDVVDVVALGESMVTFLPSRPGRLADVPSFDRAIGGAESNVACVLAAAGHSARWAGRVGADGFGDHLVEAIGAYGVDVSAVRRDPARPTGVYFRTAGDRATDAHEVAYYRAGSAASAMSVDTMDLDAIRSGRVLHLSGITPALSAGCLGLMRELTARRPGRPLVSFDVNHRPGLWRDARHGHGPEVLLELARGADLVFVGDDEARDAWGLGGPEAVRAALPEPELLVVKQGASGATAFHGTDATSVPALHVDVVAAVGAGDAFAAGFLSATLRGKPVRERLRHGHLWAAAALTVPADLAAPPARGHADRLVALDDTAWGRLRLGPGWTHAEEGAEEEVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RW7</accession>
    <name>Q93RW7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1859</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626126.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028015.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1859"/>
    <dbReference type="GeneID" id="1097293"/>
    <dbReference type="KEGG" id="sco:SCO1859"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1883"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_11"/>
    <dbReference type="InParanoid" id="Q93RW7"/>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="PhylomeDB" id="Q93RW7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC38794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="35138" checksum="65779792BBC676A9" modified="2001-12-01" version="1">MRDDGAALVDLAVNVRAGTPPAWLREHVAASLGSLAAYPDGRAARAAVAARHGLPVERVLLTAGAAEAFVLLARALKVRRPVVVHPQFTEPETALRDAGHTVGRVLLRAADGFRLDPAAVPEDADLVVVGNPTNPTSVLHPADVLASLARPGRTLVVDEAFMDAVPGEREALAGRTDVPGLVVLRSLTKTWGLAGLRIGYVLADPETVAGLERAQPLWPVSTPALAAAEACVAPRALAEAAHAAHRVAADRDRLVAGLAVSAGAGVRVVGPAEGPFVLVGVPDGAAVRHRLRDLGYAVRRGDTFPGLGGGWLRLAVRDRATTEGFLNALDRALTATEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RZ1</accession>
    <name>Q93RZ1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6000</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC37549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630115.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972922.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6000"/>
    <dbReference type="GeneID" id="1101442"/>
    <dbReference type="KEGG" id="sco:SCO6000"/>
    <dbReference type="HOGENOM" id="CLU_131550_1_3_11"/>
    <dbReference type="OMA" id="FTASVWT"/>
    <dbReference type="PhylomeDB" id="Q93RZ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="8736" checksum="5AC8551C808FDE92" modified="2001-12-01" version="1">MMGRYPGMWGKQGAGAVHEGRPLWRRSSVCGNESECVEVAVCEGRVLARDSKTLGRTPLGFSASVWTDFLHAVAQGELDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q75</accession>
    <name>Q99Q75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.283</name>
        <name evidence="1" type="ordered locus">SCP1.70c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="17510" last="17515">
            <title>2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining.</title>
            <authorList>
                <person name="Corre C."/>
                <person name="Song L."/>
                <person name="O'Rourke S."/>
                <person name="Chater K.F."/>
                <person name="Challis G.L."/>
            </authorList>
            <dbReference type="PubMed" id="18988741"/>
            <dbReference type="DOI" id="10.1073/pnas.0805530105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639645.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639893.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039371.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095149"/>
    <dbReference type="GeneID" id="1095366"/>
    <dbReference type="KEGG" id="sco:SCP1.283"/>
    <dbReference type="KEGG" id="sco:SCP1.70c"/>
    <dbReference type="HOGENOM" id="CLU_3048292_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="54" mass="6272" checksum="9FAE0E55500731F2" modified="2001-06-01" version="1">MQTDLRRYDFLTHPVFPALMPDAVRSMVNVFHHPPCFSFGVPTRSPSRRRPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACS6</accession>
    <name>Q9ACS6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">23.ORF3</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639833.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039525.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095306"/>
    <dbReference type="KEGG" id="sco:SCP1.226"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8169"/>
    <dbReference type="HOGENOM" id="CLU_157317_0_0_11"/>
    <dbReference type="OMA" id="IHRAHTE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="128" mass="13662" checksum="E95DA8160652B986" modified="2001-06-01" version="1">MIVEHYVLDNRTLLALGGNKQVSGLIHIAAGDPTVRLWVPIVCALEAERERAGIVDYLGILDVLHTLDADYAAAHSVADLYRRNVPFGVGAAVHATQPTLDRPDGAVVATVAPADYDGLEAPVLDLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACU7</accession>
    <name>Q9ACU7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.206c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639810.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039504.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095284"/>
    <dbReference type="KEGG" id="sco:SCP1.206c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8143"/>
    <dbReference type="HOGENOM" id="CLU_1531665_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="175" mass="18977" checksum="69DE95101CA8A06C" modified="2001-06-01" version="1">MNGDCCAEPVAGPVVDARVLRHAWTALGPLRCGDWPAPYSLQPPHRKETLAVLDEVLAGVYLAVDAEGRLRWLGKAHRDGGIGARLRDHLRHLERARVFTEVFVVEADPFSPPQAIEAAEGRAGDAIGLRSLMGTRRWPTVTQAQWLALVTSRPGRRVVPPRRDGDSNGGGGVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACV7</accession>
    <name>Q9ACV7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.195c</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639788.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039493.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095273"/>
    <dbReference type="KEGG" id="sco:SCP1.195c"/>
    <dbReference type="HOGENOM" id="CLU_794341_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="349" mass="34682" checksum="1D528287B1F7F188" modified="2001-06-01" version="1">MPPRGVQGPFETGAEAAANDLLDAQFLAWTGRRRGVLERLFGFLRGEAVCGDEASESVGGPVEDVGEACSLDYLAASLNWGEDSGKGTFGLDPTAAGGKDSLPGARWDGAGSGNGRCGQVAGAVQLLGEPQRKSRRLANLTHGSVGAVVCGGTRGNDVAAVSADVDLPGQGTAGAGAGRGLPLTVACGPVPHVQSPGGRAHAQGSGVISRALLTAQSGENCEGVKAVGKTGEVDLVADGNAGQDPVAYRGFSAVGVDVDDHQAGRAAGDADAELRMPPPPLLDAVLVQGGRVEAVTPAACAEAGAVGRSVGAGTAVAAVRSWCFTAWREGVDGPASAGARLGCGKRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADB0</accession>
    <name>Q9ADB0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0517</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58277.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624831.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0517"/>
    <dbReference type="GeneID" id="1095940"/>
    <dbReference type="KEGG" id="sco:SCO0517"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2837587_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9ADB0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB58277.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="66" mass="7618" checksum="847872B18BAA8F4B" modified="2001-06-01" version="1" fragment="single">RVVRVAREVRVAEGTRLFEEGRRAELFRIVRTRTVGLDLRVPGRRSPVVETPGHGELVGWCWHFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJY4</accession>
    <name>Q9AJY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative insertion element transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7746</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631782.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7746"/>
    <dbReference type="GeneID" id="1103184"/>
    <dbReference type="KEGG" id="sco:SCO7746"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7867"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="InParanoid" id="Q9AJY4"/>
    <dbReference type="OMA" id="WRIFEAM"/>
    <dbReference type="PhylomeDB" id="Q9AJY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC22754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="123" mass="13848" checksum="F501550928104E1A" modified="2001-06-01" version="1">MSVRLVITDAMWDRIKPLMPVEPVRGRRWANRRRTLETIAWKFRTGSPWRALPDELGSFQTAHKRLLRWAAYGIWERILAALPAAADGVDDIGWTVSVDSTVCRAHQHAAGARIKGHHGTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJZ6</accession>
    <name>Q9AJZ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7732</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631770.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031867.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7732"/>
    <dbReference type="GeneID" id="1103170"/>
    <dbReference type="KEGG" id="sco:SCO7732"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7854"/>
    <dbReference type="HOGENOM" id="CLU_1958381_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC22740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="128" mass="13727" checksum="6F836A61711E38A6" modified="2001-06-01" version="1">MAAEAHGGARARLSAVAEDPAGGWDPAIRLAQDAALLGRLLAAAAGQRQDGGQCPDVSADEVAAGLSLFEVMRVALDRLETQVVIEARRRGMDWRQIAGHQGLNSSQAASQRYQRLVTRLEEIRQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK83</accession>
    <name>Q9AK83_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1379</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625663.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977447.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1379"/>
    <dbReference type="GeneID" id="1096802"/>
    <dbReference type="KEGG" id="sco:SCO1379"/>
    <dbReference type="eggNOG" id="COG3861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140819_1_0_11"/>
    <dbReference type="OMA" id="DFGVGRH"/>
    <dbReference type="PhylomeDB" id="Q9AK83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="14258" checksum="38ECE10F096A86DC" modified="2001-06-01" version="1">MEGPVRTDIDPRNLIGRKAFDRDGSRIGTVDEVYLDDATGVPEWAAIRTGLFSRDAFVPLEPSELVDGALRVPFDRALIKEAPDFGVGRHLSPEQELQLYHHYGLDVAAAPPPPDHDFGKLAGKGKGPDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX33</accession>
    <name>Q9EX33_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625303.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027514.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1007"/>
    <dbReference type="GeneID" id="1096430"/>
    <dbReference type="KEGG" id="sco:SCO1007"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1003"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EX33"/>
    <dbReference type="OMA" id="YIAYFSI"/>
    <dbReference type="PhylomeDB" id="Q9EX33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="41268" checksum="86178BD73F6842F6" modified="2001-03-01" version="1">MKKPEVLIVGAGIAGPALAYWLSRNGYRPTVVEHARQLRSGGSAIVVKGPAVPVADRMGILPQLRELATRNRSLTLLDPGGRRILQLPLTSDKAPTVEVTRADLSEVLHRSAQTEAEFVFDDTVIALDQDEGGVDVTFRRSTPQRFDLVVGADGMHSTVRRLVFGPEWQFANDLGLYGATVPLAPDAVEDPTEMTMLTVPNRMLVLHPSRTTPLAIFTFRVAQPAPHDRKNIALHKQTVADAYADVRWRAPELVAAFLDHPAPYFDPLSTVRVPSWSRGRVVLLGDAAAATALLGDGSSMAMAGAYALAEELAAHPGDHARAFAAYESRLRREVGPRQRRVGLLSGLMVPRTRPGLAVRNAVGRAVGRTNRITSRETANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX55</accession>
    <name>Q9EX55_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6272</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC22143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630371.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030784.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6272"/>
    <dbReference type="GeneID" id="1101713"/>
    <dbReference type="KEGG" id="sco:SCO6272"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6388"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_2_0_11"/>
    <dbReference type="InParanoid" id="Q9EX55"/>
    <dbReference type="OMA" id="HDLWWAH"/>
    <dbReference type="PhylomeDB" id="Q9EX55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176649" evidence="3">
        <location>
            <begin position="33"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC22143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="550" mass="59895" checksum="EB4A23E0F58E4ABC" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2M5</accession>
    <name>Q9F2M5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3756</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627946.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975186.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3756"/>
    <dbReference type="GeneID" id="1099192"/>
    <dbReference type="KEGG" id="sco:SCO3756"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3816"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9F2M5"/>
    <dbReference type="OMA" id="YKKRLMQ"/>
    <dbReference type="PhylomeDB" id="Q9F2M5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC10294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24128" checksum="9A0AB85686B548EA" modified="2001-03-01" version="1">MTTRVIIVDDQAMVRAGFAALLAAQSDIDVVGEAPDGAQGVELSRRTHPDVVLMDVRMPEMDGLEAARRLLSPPPGVTHRPRVLMLTTFDVDDYVYEALRAGASGFLLKDAPPADLIAAVRVVASGDALLAPSVTRRLIADFAQQRPASRGKPALRLKGLTERETEVLTLVARGQSNTEIARTLVLAEQTVKTHVSRVLTKLDLRDRAQAVVFAYESGLVAPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2X0</accession>
    <name>Q9F2X0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4591</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628753.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029748.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4591"/>
    <dbReference type="GeneID" id="1100031"/>
    <dbReference type="KEGG" id="sco:SCO4591"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4663"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_3_1_11"/>
    <dbReference type="InParanoid" id="Q9F2X0"/>
    <dbReference type="OMA" id="NRHKVRA"/>
    <dbReference type="PhylomeDB" id="Q9F2X0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="21191" checksum="98DE1EB0E0C1545A" modified="2001-03-01" version="1">MSHEGRSYRFDPGALCLELLTTGGPGAFARWEVLHEPADLMTWVERSRLADGLDLSVDRADVARTRALRDALFLLAADRAHGRPLRRDHLEAVNSAAAEPPLVTRLEPDGTRGWAPGATGSRLLSTVARDAIELFTGPYADRIRECGAHNCFLLFVDTSRPGRRRWCAMEHCGNREKVRAHRARRAPDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3I0</accession>
    <name>Q9F3I0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2801</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627031.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975999.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2801"/>
    <dbReference type="GeneID" id="1098235"/>
    <dbReference type="KEGG" id="sco:SCO2801"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2859"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="InParanoid" id="Q9F3I0"/>
    <dbReference type="OMA" id="WQQSYGD"/>
    <dbReference type="PhylomeDB" id="Q9F3I0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="26085" checksum="B1666CCE98C92E30" modified="2001-03-01" version="1">MPPMASVLVVEDDQFVRSALIRQLTDASHTVRSVGTALEALREVAHFRFDVVILDLGLPDLDGSEALKMLRGITDVPVIVATARDDEAEVVRLLNAGADDYLTKPFSVEHLSARMAAVLRRARGGPAEAAPPTVLRVGGLTVDPLRRQAELDGTALDLTRREFDLLAFLAGRPGVVVPRKELLAEVWQQSYGDDQTIDVHLSWLRRKLGETAARPRYLHTLRGVGVKLEPPRLEPPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC36</accession>
    <name>UPPP1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase 1</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP1</name>
        <name type="synonym">bacA1</name>
        <name type="synonym">upk1</name>
        <name type="ordered locus">SCO7047</name>
        <name type="ORF">SC4G1.13</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631109.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972097.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FC36"/>
    <dbReference type="SMR" id="Q9FC36"/>
    <dbReference type="STRING" id="100226.SCO7047"/>
    <dbReference type="GeneID" id="1102485"/>
    <dbReference type="KEGG" id="sco:SCO7047"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7151"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FC36"/>
    <dbReference type="OMA" id="PIMMGAS"/>
    <dbReference type="PhylomeDB" id="Q9FC36"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000151211" description="Undecaprenyl-diphosphatase 1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="278" mass="29480" checksum="522A6F040FA67458" modified="2001-03-01" version="1">MSAISIGQAVVLGAVEGVTEFLPVSSTGHLKIVEGLMGIPVDDDAVIGFSAVIQVGAIAAVLVYFSKDIMRIVSAWGRGLRDREERYHHDYRFAWWVIYATIPIVLVGLAAKPLIKGPLASLWVVAGSLIVGSGVMWWADRTGRHKRGEDDTSFKDAMLVGGSQILALLFPGFSRSGATMSTALMLDLDRVAATRLSFFLGIPALTGAGLYELKDALGTGAGAAPLAVGTLVSFVVAYASIAWLLKFVAKHTFNSFVVYRIAVGVLLFGLLGTGVLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCB8</accession>
    <name>Q9FCB8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1249</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625537.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977581.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1249"/>
    <dbReference type="GeneID" id="1096672"/>
    <dbReference type="KEGG" id="sco:SCO1249"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1249"/>
    <dbReference type="eggNOG" id="ENOG5032GV0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188479_0_0_11"/>
    <dbReference type="OMA" id="AADFMKQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="75" mass="8493" checksum="FD70BD5BF5AC802B" modified="2001-03-01" version="1">MAKTRKAQLNVRVDEGTVRAAREKALARGMSVNRYIEELVRQDTGEAGRTFVEAAADFMRQYEKVFAEEAGEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCE3</accession>
    <name>Q9FCE3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4227</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628402.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029518.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4227"/>
    <dbReference type="GeneID" id="1099667"/>
    <dbReference type="KEGG" id="sco:SCO4227"/>
    <dbReference type="eggNOG" id="ENOG5031T3V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2604422_0_0_11"/>
    <dbReference type="OMA" id="GCQSGNP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="7889" checksum="0348C487D1FAA75D" modified="2001-03-01" version="1">MDSGPQGPEPRTPGPGSQDPRHPLPGGTMADSPSTKPDPAQERPTEQPTEIRSLPLIAACGCGSGCGCGCQSGSPCQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X1</accession>
    <name>Q9K3X1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative mut-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4373</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628542.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029613.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4373"/>
    <dbReference type="GeneID" id="1099813"/>
    <dbReference type="KEGG" id="sco:SCO4373"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4441"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126604_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3X1"/>
    <dbReference type="OMA" id="QPPGRGW"/>
    <dbReference type="PhylomeDB" id="Q9K3X1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB95884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="21000" checksum="793886616EC5AF9B" modified="2000-10-01" version="1">MSGCQRASVRRAGTARSTPAHPRPAPHRAGTVHRVRRLLTRLWRLLRPVQSRLMWLVNAKFVVGVTGVVRDDEGRVLMLKHRLWPPGRQWGLPSGFAHRGEDFRQTVVREVREETGLDVEAGRLVMLNSGLRTRLEVAYEARLLGGELRLDPFEILEARWCRPDELPEDVQPVCRPLVRGETVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Z9</accession>
    <name>Q9K3Z9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1334</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977493.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1334"/>
    <dbReference type="GeneID" id="1096757"/>
    <dbReference type="KEGG" id="sco:SCO1334"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1340"/>
    <dbReference type="eggNOG" id="ENOG5031SAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193865_2_1_11"/>
    <dbReference type="OMA" id="EWASAIR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="59" mass="6488" checksum="692FE1886B84DBC4" modified="2000-10-01" version="1">MSPDYVTPGSVRSAAELNDQIRALWRRAGGTLSAQERVEYELLVVEWATAIRGQVVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K428</accession>
    <name>Q9K428_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1071</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625365.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027559.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1071"/>
    <dbReference type="GeneID" id="1096494"/>
    <dbReference type="KEGG" id="sco:SCO1071"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1069"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9K428"/>
    <dbReference type="OMA" id="YPYGPVF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="312"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="415" mass="44894" checksum="924E8F64B23446A9" modified="2000-10-01" version="1">MDGQRERAGRAPQWWWHGPPWWNRRGDEEQRPARPWRSTVLVTAFVLVGSSFAAHAQEAERAALDPFARVLLFVTGAALLWRQRYPVPVVFGTAVTTLVYLGAGYPYGPVFVAVAVACFSAVVTGHRRAAWAAMGTLWAGHALVAHWLYRWLPPSGDSAASWGQELVIATWVVAIAALSELARARREQWARERAERAQAARRRADEERLRIARELHDVLAHSISVINVQAGVGLALLDTDPEQARTALTTIKDQSKEALGEVRQVLDTLRTPGDAPRAPAPGLDRLPELVEQAAGAGLTVEVEGKPPRLSPGTDLAAFRIVQEALTNVVRHSGSRHARVRLGRDGGTLLLRVDDDGPATGAEAGGSGNGLAGMRERAAALGGTIEAGPRPDGGFRVLAALPIDVKHPNRTKEDDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K470</accession>
    <name>YZZE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>UPF0157 protein SCO7215</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO7215</name>
        <name type="ORF">SC2H12.14c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0157 (GrpB) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631271.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031516.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K470"/>
    <dbReference type="SMR" id="Q9K470"/>
    <dbReference type="STRING" id="100226.SCO7215"/>
    <dbReference type="GeneID" id="1102653"/>
    <dbReference type="KEGG" id="sco:SCO7215"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7314"/>
    <dbReference type="eggNOG" id="COG2320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086407_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K470"/>
    <dbReference type="OMA" id="HVFGPDC"/>
    <dbReference type="PhylomeDB" id="Q9K470"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000216130" description="UPF0157 protein SCO7215">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="186" mass="20757" checksum="38545B835F9C09DB" modified="2000-10-01" version="1">MTNSSGRRRPDVTTVEIIGGPEALEIGLSDYDARWAETYLRHRRRILDALGADVDVEHIGSTSVPGLAAKPIVDIVVAVADITSEEDYLDALLAAGYELRVREPGHRLVRTPGRDVHVHVYERGAAAVHEYLLFRDHLRADADDRALYENVKRALFEQPWNDMNDYSDAKSDVILAIKSRAGAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K481</accession>
    <name>Q9K481_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7204</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631260.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031508.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102642"/>
    <dbReference type="KEGG" id="sco:SCO7204"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7304"/>
    <dbReference type="HOGENOM" id="CLU_2865741_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6839" checksum="CE93B4BA5120F474" modified="2000-10-01" version="1">MPSSYYPPVKTDDDLRPSVDHAVAGPVIAELPDGLRSLPTRMFRGAVELSGGEAESRPNPHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXI2</accession>
    <name>Q9KXI2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2338</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626585.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976466.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KXI2"/>
    <dbReference type="STRING" id="100226.SCO2338"/>
    <dbReference type="GeneID" id="1097772"/>
    <dbReference type="KEGG" id="sco:SCO2338"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2376"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_8_0_11"/>
    <dbReference type="InParanoid" id="Q9KXI2"/>
    <dbReference type="OMA" id="MGEHPRL"/>
    <dbReference type="PhylomeDB" id="Q9KXI2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="23600" checksum="5721B61C09D47E4A" modified="2000-10-01" version="1">MSESQVWDDVDAYFVTHLAPDDDALAAARRESDAAGLPPVNVAANQGKLLQLLAQIQGARTILEIGTLGGYSTIWLARALPAEGRLVTLEYSARHAEVATRNIARAGLDALVDVRVGPALESLPKLADENPPPFDLVFIDADKGNNPHYLEWALRLTSTGSLIVIDNVVRGGRVADAGDTGDDVRGTRAAIELIGSHPRLSGTALQTVGTKGYDGFALARVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXQ2</accession>
    <name>Q9KXQ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1498</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625778.2">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1498"/>
    <dbReference type="GeneID" id="1096924"/>
    <dbReference type="KEGG" id="sco:SCO1498"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1507"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXQ2"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="PhylomeDB" id="Q9KXQ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="4">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB93378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="26535" checksum="C05E190E764346C8" modified="2000-10-01" version="1">MLHRAAYAELGLADWTYDHFDVDEAALPGFLEGLGPEWAGLSLTMPLKRAVIPLLDSVSETAASVDAVNTVVLTEDGRRTGDNTDIPGIAAALREHGIEKVESAAILGAGATASSALAALARICTGEVTVHVRSAARAAEMRGWAERLGVDVRLADWADAAEALRAPLVVATTPAGATDALAAAVPEMPTTLFDVLYDPWPTALAARWSAHGGAVVSGLDLLLHQAVLQVEQMTGRAPAPLAAMRKAGEHALADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXT0</accession>
    <name>Q9KXT0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628483.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029571.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4311"/>
    <dbReference type="GeneID" id="1099751"/>
    <dbReference type="KEGG" id="sco:SCO4311"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4379"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066230_0_0_11"/>
    <dbReference type="OMA" id="VRAFHPY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:peptide-serine-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017198">
        <property type="term" value="P:N-terminal peptidyl-serine acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="202"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="365" mass="38940" checksum="8148463E112B970C" modified="2000-10-01" version="1">MRTLGGEQVEEAVAGAVALLRTATDRDWESVRAGRSEWDCRYTAEHVAGILVTYAGQLAGRATEGWVPFEITFDEGTGNEGVLQVAETTGVLLAATLRATPREVRAFHPYPFRSADREGFAAMAITEVFLHTHDIAEGLGLTYAPPAERCADLLARLFPHVRPDTDPWRTLLWATGRGDLPGRAPVTEWRWRNNLVIPAERLTLQGVTPAAAADLAAGGDGGFAWIDGGPFQGTRDAAGMLVKAYETGVHRPAWGVFALVRREDGRAVGGIGFHGVPNEKGRVEIGYDLVEAARGNGYATEGLRALSAWALGRETVTSVRATTDPENTASQAVIVRAGFTRVAGDSAEGGEAGEGAGQFAYELRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY07</accession>
    <name>GCS2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="1">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="1">GCS 2</shortName>
            <shortName evidence="1">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO7331</name>
        <name type="ORF">SC410.10c</name>
        <name type="ORF">SC4G10.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631385.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031591.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KY07"/>
    <dbReference type="SMR" id="Q9KY07"/>
    <dbReference type="STRING" id="100226.SCO7331"/>
    <dbReference type="GeneID" id="1102769"/>
    <dbReference type="KEGG" id="sco:SCO7331"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7435"/>
    <dbReference type="eggNOG" id="COG2170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044848_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KY07"/>
    <dbReference type="OMA" id="WQRWPSA"/>
    <dbReference type="PhylomeDB" id="Q9KY07"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000218222" description="Putative glutamate--cysteine ligase 2">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <sequence length="363" mass="39895" checksum="A68F0F516509E81B" modified="2000-10-01" version="1">MRTVGVEEELLLVDPATGEPRALSAAVLARAFLDDSEQDVFEKELHEQMLEFATHPQADMERLHAEIVRCREEAGRHAGGIGCAVAALATSPLPVTPSIGVNRRYEWMAEQYGVVVHEQLVLGCHVHVSVDSDEEGVAVIDRVRPWLPVLAALSANSPFWQGRDSSYSSYRSRVWQRWPSAGPTELFGSAERYHRRVADMLATGTVLDDGMVYFDVRLSQRYPTVEFRVADVCLDASTAVVLAALARALVDTAAREWRAGAEPAEHSVSLLRLAAWRAARSGLTSELLHPATMRRMPAESVVRDLLEHAGEALAAAGDLERVREGVEKLLRHGNGARVQRELLARTGSLREVVAACVRRTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYC3</accession>
    <name>Q9KYC3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6907</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630976.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031292.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6907"/>
    <dbReference type="GeneID" id="1102346"/>
    <dbReference type="KEGG" id="sco:SCO6907"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_4_1_11"/>
    <dbReference type="InParanoid" id="Q9KYC3"/>
    <dbReference type="OMA" id="DHPWPER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006266">
        <property type="term" value="P:DNA ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="1">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="26966" checksum="64BB5732CC06E473" modified="2000-10-01" version="1">MLCRLAETVRLQARSGRDVTTPWMDLAVAGMALPPGVVLDGEAVVVVDGRVSFEAAQARAASSPARSRELAARHPALLIVWDVLALPTGDVRGRPYEERRVLMLDVVAGLPEGSPIQAVSATEDVEIAQVWYETLAGSGVDGVVAKSGRSPYRAGRSSSWKKVRHAETLDAEVVGFTGTASRPRALAVRLPDGRVALSQRLGAQLAAQVAAALVNNAPAARGRAAGGESFKATEPGLLVEVLAGTTRHAVVTVTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYV0</accession>
    <name>Q9KYV0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3195</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627409.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3195"/>
    <dbReference type="GeneID" id="1098629"/>
    <dbReference type="KEGG" id="sco:SCO3195"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3255"/>
    <dbReference type="eggNOG" id="ENOG5033SS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986687_0_0_11"/>
    <dbReference type="OMA" id="LWEVEHT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046195">
        <property type="entry name" value="DUF6227"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19738">
        <property type="entry name" value="DUF6227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB90979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="24979" checksum="369555EF0F1F4B40" modified="2000-10-01" version="1">MRLLGRALNSFELPDETIRLLDCALAHDGSLHSAHHSAGLHRETYRHTWLLADGSALTLWELVHNTAPGSEPQHEVYLDEEELRAAGSRLALPPEAPDFELPVQVQLSPVPAPRHAYVPDASADHARRLLRRAENADRPDADLAARLSTACGHQITQAFGGPGRAGRARVGFSLYEHAFLLRDGVEVSLWEVEHTATPDGRHMCEVYDSEDTARRAMERRAAQVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYV5</accession>
    <name>Q9KYV5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ordered locus">SCO3190</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627404.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975627.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3190"/>
    <dbReference type="TCDB" id="1.A.22.1.10">
        <property type="family name" value="the large conductance mechanosensitive ion channel (mscl) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1098624"/>
    <dbReference type="KEGG" id="sco:SCO3190"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3250"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KYV5"/>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="PhylomeDB" id="Q9KYV5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009992">
        <property type="term" value="P:cellular water homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB90974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="16719" checksum="E34999F32FE48169" modified="2000-10-01" version="1">MSEKNEPSVWQGFKAFLMRGNVIDLAVAVVIGAAFTKIVNSVVDGVINPLVGAFGTQSLDSYSSCLKGPCTGTGDSATGVRILWGSVLGATLTFLITAAVVYFLMVLPMSKYLARQEARRKAKESAEEVIEVSELEVLKEIRDALIAQRGSGHDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN4</accession>
    <name>Q9KZN4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1398</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625681.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027765.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1398"/>
    <dbReference type="GeneID" id="1096824"/>
    <dbReference type="KEGG" id="sco:SCO1398"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1177637_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9KZN4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="39"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="236" mass="24497" checksum="AAFA575BCA785168" modified="2000-10-01" version="1" fragment="single">MRALAESRVEEAAGLNPLTRLPGSQAITDEVDRRIAAGRAFALSWLDVDHFKQVNDGAGFAAGDELIRSVGQALLRTAGGETRVGHIGGDDFLMLSDPDGLDRLAAAVLDVAWSAGGRPVTLSLATVLCGPGSVPDHRRAAARLAPLKKAAKALGGASWVLGRADVPGHEVMRGPDDGAGRLSGRAGGRRRFRAEPGGSGRGTLRGFRQTYGGRAGDDVRRPGGEPLRSTPAARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZS3</accession>
    <name>Q9KZS3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2878</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627106.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028642.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2878"/>
    <dbReference type="GeneID" id="1098312"/>
    <dbReference type="KEGG" id="sco:SCO2878"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2938"/>
    <dbReference type="eggNOG" id="ENOG5031CH2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389751_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="576"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="849" mass="88527" checksum="890B92EA082FF0EC" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L004</accession>
    <name>Q9L004_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2309</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626557.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028270.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1097743"/>
    <dbReference type="KEGG" id="sco:SCO2309"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2346"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q9L004"/>
    <dbReference type="OMA" id="CAGQFLV"/>
    <dbReference type="PhylomeDB" id="Q9L004"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB88187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="489" mass="49198" checksum="CE013FC0B232E52F" modified="2000-10-01" version="1">MTPMLEATGSPASATARISPRRTPPTWLVVALACAGQFLVVLDVSVVNVALPSMRADLGLSAQGLQWVVNAYAIAFAGFMLLGGRAGDLYGRKRMFLVGLGLFTLASLGGGLAQEGWQLLVARALQGLGAAVLAPSTLTILTAAVPEGAARARAIATWTAVGAGGGAAGGLVGGALVDGLSWRWVLLINVPVGAVVLAGAALWLAESTGGPRRRLDLPGALLVTAGLATLAYGISQTESEGWAAPAALVPLSAGLALLGLFLLVEARTAAPLMPLGLLRLRSVASANVAMLVSGSSMFSMWFFMTLYAQNVLGYSPLEAGVALVPSSLAVILGSKAAPRFMPVLGARNVAVLGTLVAAVGFGWQSTMTADGGYLTAIMIPGVLMMLGAGIAATPLASLAISGAAPGDAGLVSGLINTSRTMGGSLGLAVMSTIAATRAGGEDAGPVALTDGYALVFRTAAVVLVAAALLMWTWLPAGRPKPELKAHSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L007</accession>
    <name>Q9L007_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2306</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626554.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028267.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2306"/>
    <dbReference type="GeneID" id="1097740"/>
    <dbReference type="KEGG" id="sco:SCO2306"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2343"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_5_2_11"/>
    <dbReference type="InParanoid" id="Q9L007"/>
    <dbReference type="OMA" id="ISEWTPV"/>
    <dbReference type="PhylomeDB" id="Q9L007"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB88184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="25058" checksum="054E27C7F8C7F5EC" modified="2000-10-01" version="1">MRDYLILETRRTLRDPGFVVGGVAMPVLMYLLFTNLGGDAGEWKTGAMVGMAAYGAVGSALNTGGGVAEDRAIGWLRQLRVTPMRPHQVVVGRALTASVTVLPAITAVLAAGGLLNGVRLDAWQWAALALLLWFGSVPFTLLGLGNGYRLTGQTTGVANMVANLGLAVLGGLWFPLVLFPEWLRTVSAYTPTNRFAQLGTSVATGHAPDAGAILVLTGWLLAFGAYAVLSYRRGTAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L013</accession>
    <name>Q9L013_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2300</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626548.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028262.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2300"/>
    <dbReference type="GeneID" id="1097734"/>
    <dbReference type="KEGG" id="sco:SCO2300"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2337"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L013"/>
    <dbReference type="OMA" id="CQGCRQE"/>
    <dbReference type="PhylomeDB" id="Q9L013"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="3">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="21613" checksum="D246F3674D40EC87" modified="2000-10-01" version="1">MAAQTEESDCAREQTKAEQDVDQVRQRAGRDQQRLDSGAVTSPKDLENLQREIASLAKRQGDLEDVVLEVMERRESAQERVAELTERVGAVQGKIDDATARRDAAVEELDAEITSVTKEREVVAGSVPDDLLTLYGKLREQQGGVGAAKLYQRSCQGCRQELAITELSEIRSAAPDTVVRCENCRRILVRTADSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L031</accession>
    <name>Q9L031_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7024</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631088.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031387.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7024"/>
    <dbReference type="GeneID" id="1102462"/>
    <dbReference type="KEGG" id="sco:SCO7024"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7128"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_0_11"/>
    <dbReference type="InParanoid" id="Q9L031"/>
    <dbReference type="OMA" id="IGYWIDT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:peptide-serine-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017198">
        <property type="term" value="P:N-terminal peptidyl-serine acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="188" mass="20510" checksum="74936433B1A63E9A" modified="2000-10-01" version="1">MTKGSLSGLPRENIELPDGSVLRRRSLVSDDAFIDAVTADVGHLGEWLRWARHPPTREETERFRAEQDADWDAGRSFVYVLTPPDRHDQVLGGGAMFPNGEVGVLEIGYWVCSPATGRGLATRAAAALTEEGLGLPGVKAMEIHCDRANARSAAIPPRIGYRLLRIEADEPQTVAEAGRSMVWRHDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L094</accession>
    <name>Q9L094_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2452</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626695.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028361.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2452"/>
    <dbReference type="GeneID" id="1097886"/>
    <dbReference type="KEGG" id="sco:SCO2452"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2494"/>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034370_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L094"/>
    <dbReference type="OMA" id="HRFGPSM"/>
    <dbReference type="PhylomeDB" id="Q9L094"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="151"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB86117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="475" mass="50376" checksum="09DD056DE2E88A68" modified="2000-10-01" version="1">MSARPAPRLARLLEALLDVGTALDLRGVLQHIVDGAAELTGADRADLVVADPDAGGLAEIRTPGPDRPVPETAPLLRMPVHVRDEEFGELRLAGRAGAAPFTVEDEQLLRVLAVQAGVSIGNARLYETARQRERWIEGAAAVTTALLTEEGAGDALTTVAERARLLADACAGVILHPTAEGGMAIVTASTPDDPDGMVGATIEPGSPVLEQLLGGEPVFVDDSATDPRMTTHVRHRFGPSMMLPLQAGGRLIGTLALPRRRGGRPYTDLERLLATQFASQAALALVLADARRGRELLAVYEDRDRIARDLHDLVVQRLFATGMMLESTRRRPGADDVRDILGRAVEELRSTVGEVRTAILTLQQPPAGPPAGLRGRVLRETASAAARLGTAPSTHFRGPVDARVPDRVADRLLTALRDALAAASARPDVSRVEVAVETPAPSPEGRDGVRLRVADYGADAGGRGRGTTVTWWAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0D8</accession>
    <name>Q9L0D8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="11" type="ordered locus">SCO4704</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974265.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4704"/>
    <dbReference type="GeneID" id="1100145"/>
    <dbReference type="KEGG" id="sco:SCO4704"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4775"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843914_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0D8"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="PhylomeDB" id="Q9L0D8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB82072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="14978" checksum="048E25016F7A1CFD" modified="2000-10-01" version="1">MATRHPSIASKAAKAAKAARVAKARRHEAEGKNTVVTPASKAFTDPRDVLLKPVVSEKSYALLDENKYTFVVAPGSNKTQIKEAVQAVFSVKVTGVNTINRQGKRKRTRTGFGKRADSKRAIVTLAEGDRIDIFGGPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L152</accession>
    <name>Q9L152_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO7407</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631456.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031640.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L152"/>
    <dbReference type="STRING" id="100226.SCO7407"/>
    <dbReference type="CAZy" id="GH42">
        <property type="family name" value="Glycoside Hydrolase Family 42"/>
    </dbReference>
    <dbReference type="GeneID" id="1102845"/>
    <dbReference type="KEGG" id="sco:SCO7407"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7517"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L152"/>
    <dbReference type="OMA" id="SRRHYCF"/>
    <dbReference type="PhylomeDB" id="Q9L152"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_hydro_42M"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52317"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="9">
        <location>
            <begin position="408"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="10">
        <location>
            <begin position="623"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="319"/>
        </location>
    </feature>
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        <location>
            <position position="123"/>
        </location>
        <ligand>
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            <position position="161"/>
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            <position position="327"/>
        </location>
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        </ligand>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB76326.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="681" mass="74602" checksum="2457A757D8677483" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1H4</accession>
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        <submittedName>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAB75384.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="518" mass="58526" checksum="887DA80F6E924791" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1J4</accession>
    <name>Q9L1J4_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">SCO2722</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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                <person name="Parkhill J."/>
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            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626955.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028540.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2722"/>
    <dbReference type="GeneID" id="1098156"/>
    <dbReference type="KEGG" id="sco:SCO2722"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2778"/>
    <dbReference type="eggNOG" id="COG1277">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069607_0_0_11"/>
    <dbReference type="OMA" id="FLPAHWQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB75311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="30746" checksum="7BB332A01F74A7FE" modified="2000-10-01" version="1">MSTPTKPATTGPAPGPASASDSASGYRAGRTLPLRVELVRQLKRRRTLAMGAILAVLPFVLVVAFAIGGEPEGPGDRITLMDTATASGANFAAVNLFVSAGFLLVVPVALFCGDTVASEASWSSLRYLLAAPVPRARLLASKLAVGLGLSLAAMVLLPLVALAVGTVAYGWGPLAIPTGGSLAPGTAAQRLVVVVAYIFVSQLVTAGLAFWLSTRTDAPLGAVGGAVGLTIVGNVLDAVTALGHWRDFLPAHWQFAWADAVQPNPEWSGMIQGTAVSVTYALVLFALAFRGFARKDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1L0</accession>
    <name>Q9L1L0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5434</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629572.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030245.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5434"/>
    <dbReference type="GeneID" id="1100874"/>
    <dbReference type="KEGG" id="sco:SCO5434"/>
    <dbReference type="eggNOG" id="COG4565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_39_1_11"/>
    <dbReference type="InParanoid" id="Q9L1L0"/>
    <dbReference type="OMA" id="DVHGLQL"/>
    <dbReference type="PhylomeDB" id="Q9L1L0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB72410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="24612" checksum="D3EA410D14188E4B" modified="2000-10-01" version="1">MSTADSQPIRVLVVEDDPVAADAHVMYVGRVPGFVAVGKAHTGAEARRMLDRTPVDLLLLDLHLPDVHGLQLARSLRAAGHHTDVIAVTSARDLTMVREGVSLGVVQYVLKPFTFATLRDRLVRYAEFRGTAGEASGQDEVDRALATLRAPGPAALPKGLSGPTLERVTGALRGATEGLTAAGVAEAVGISRITARRYLEHLVDAGRAGRSPQYGQVGRPELVYRWVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L201</accession>
    <name>Q9L201_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2634</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626870.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976167.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2634"/>
    <dbReference type="GeneID" id="1098068"/>
    <dbReference type="KEGG" id="sco:SCO2634"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2681"/>
    <dbReference type="eggNOG" id="COG2761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087602_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L201"/>
    <dbReference type="OMA" id="KTPVDFW"/>
    <dbReference type="PhylomeDB" id="Q9L201"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="23986" checksum="0B29132E89E3E670" modified="2000-10-01" version="1">MRRDMSEKTPVDFWFDPLCPWAWMTSRWVLEVEKVRDIEVRWHLMSLAVLNEDKLDELPAEYRELLETKAWGPVRVVIAAQEEHGADVLGDLYTALGTRIHNQEEGPGRETVAAALKDVGLPESLMDHWDGTPYEPQLRASHKEGIDKVGQEVGTPVIAVPGADGGQLAFFGPVVTPAPKGEDAAKLWDGTLAVASVPGFYEIKRTRTKGPDFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L240</accession>
    <name>Q9L240_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6792</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630864.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972206.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6792"/>
    <dbReference type="GeneID" id="1102231"/>
    <dbReference type="KEGG" id="sco:SCO6792"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6901"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_39_1_11"/>
    <dbReference type="InParanoid" id="Q9L240"/>
    <dbReference type="OMA" id="GIRRSTM"/>
    <dbReference type="PhylomeDB" id="Q9L240"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB71239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="22021" checksum="250860C28BD5CB3B" modified="2000-10-01" version="1">MTTAAKTETEDPTARRILDAALEQFTVFGLRRSSMDDVAKRAGVSRVTVYRRFGTKDALVEQTLLRENSRFFQRLDQAVAALPTMEERVVEGFVVALRHTRAHPLFGGLLRLEPEVVLPYLTVHGGSSLAATVDYLTGHLRRAQQAEGRPGDDPRPVAELMVRVAVSFLLNPASCIEMDDEDQARAFARRYLAPLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2C9</accession>
    <name>Q9L2C9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2490</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626732.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976314.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2490"/>
    <dbReference type="GeneID" id="1097924"/>
    <dbReference type="KEGG" id="sco:SCO2490"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2532"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L2C9"/>
    <dbReference type="OMA" id="PYDDFPE"/>
    <dbReference type="PhylomeDB" id="Q9L2C9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="25670" checksum="8FB1F3CE02BA845A" modified="2000-10-01" version="1">MTTQRFTGKTALVTGAGSGIGRAVALALAAEGAHVVVAGRARGPLDETAALVEQAGGKALAVTADVTRREDVDALVSAAVEHFGSLDVAVNNAGVFRGGVPVADLSEEDWHTQLDINVTGVFLALRAEVRHMRAQPGGGTIVNIASTFGAHKRSPGATAYAATKAAVSALTRGAALDHIGDGVRINAVSPGATATSMSLRPGETEAGRAERMRQETPLGRVSAVAEVAAAVLYLASDDAASVVGTDLVVDGGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCW7</accession>
    <name>Q9RCW7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0943</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625241.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977917.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0943"/>
    <dbReference type="GeneID" id="1096366"/>
    <dbReference type="KEGG" id="sco:SCO0943"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.939"/>
    <dbReference type="eggNOG" id="ENOG502ZVND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1593570_0_0_11"/>
    <dbReference type="OMA" id="HLAIHLF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB63192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18774" checksum="1B450C61BB69D997" modified="2000-05-01" version="1">MLHRGQESTDGTGGGELSVPMAWLYAEYIADELLRTGDLMPPTSFEFRAGRDALALTVFLSDTENELSGIRVVTHLETWLSLTAYDQPWHEWVHGRLAEVTADAVAAGRHSPDLELARAAWRWLQDTELLAPDLNAVPGGAPVTGEDEGPKVWTPAWQLGLPLGHLAIHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD28</accession>
    <name>Q9RD28_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625181.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977977.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0882"/>
    <dbReference type="GeneID" id="1096305"/>
    <dbReference type="KEGG" id="sco:SCO0882"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.873"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103702_3_0_11"/>
    <dbReference type="OMA" id="EHYARLM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB62673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="13167" checksum="5D6D78AB32CAAFC0" modified="2000-05-01" version="1">MDMTYYDHGTPAERWERARMFFDAKDYAAAARVLDGLVAQVPEQTGPRLLLARSYYHSAQLRRAEAELRVVVERDPVEHYARLMLGRTLERQGRQEEADAQLRIASALAGDFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDH9</accession>
    <name>Q9RDH9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="13" type="ordered locus">SCO2748</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626979.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028558.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2748"/>
    <dbReference type="GeneID" id="1098182"/>
    <dbReference type="KEGG" id="sco:SCO2748"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2804"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RDH9"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="PhylomeDB" id="Q9RDH9"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="6"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="219"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB66287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="306" mass="30726" checksum="3DE30E98420E9374" modified="2000-05-01" version="1">MYDYDLLVVGSANADLVIGVERRPAAGETVLGSDLAVHPGGKGGNQAVAAARLGARTALLARVGDDDYGRLLLDSQRAAGVDTVGVLVGGAPTGVALITVDPSGDNSIVVSPGANGRLAPGDVRAAASLFHASRVVSTQLEIPLETVVEVVRSLAPDSRFVLNPSPPRPLPQEVLTACDPLIVNEHEAKVILGDSLVGERPEDWARVLLAKGPRSVVVTLGAEGALVASAAGGVVRVPSVKVDAVDTTGAGDAFTAALAWRLGTGESLADAAAYAARVGAAAVTKAGAQESYPTAAEAEDLGAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDR7</accession>
    <name>Q9RDR7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626499.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028225.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2250"/>
    <dbReference type="GeneID" id="1097683"/>
    <dbReference type="KEGG" id="sco:SCO2250"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2287"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137029_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDR7"/>
    <dbReference type="OMA" id="ATHAHHD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="29837" checksum="65FB0958D9FA9CFD" modified="2000-05-01" version="1">MLTPVADGVLVHQSELLRNNTVVVRGESGVLIVDPGLTTGEMGCLAEDLRQLGQPVVAGFATHPDWDHALWHADLGDVPRYGTARCSAYLRELRSEEGWQARVAEGLPPEIADETPLELFGLIVGLPAGAELIPWNGPEVRVIEHPAHAPGHAALLVEDRGVLVAGDMLSDLFVPMLDDTEHPVEDYLTGLRLLEKVADDVEVLVPGHGSVATADQVQVRIGRDREYLHALRDGRAPDDPRLGSSVEPGWEWVNDIHEGQAARMARRSERNGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIZ4</accession>
    <name>Q9RIZ4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO0171</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36953">
        <property type="entry name" value="T36953"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624507.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026898.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0171"/>
    <dbReference type="GeneID" id="1095595"/>
    <dbReference type="KEGG" id="sco:SCO0171"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.144"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RIZ4"/>
    <dbReference type="OMA" id="TDTFAIQ"/>
    <dbReference type="PhylomeDB" id="Q9RIZ4"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="438" mass="46548" checksum="A9F04111AE882A1F" modified="2000-05-01" version="1">MSDVTTTDLYEVTMALSYLLEDMSRPATFSLFVRDLPSERGFLVSAGIEPALDYLSAFRVTPSDVEDFASALHRPYADLSPLCGMTFTGEVRAVPEGRVVFAGEPLLEVTAPLAEAQLVETFLLNQVSHQTAVASKAVRSVLAAAGRPVVDFSLRRTHGTSAGMQAARTAALTGFAGTSNVAAAVRWGLPASGTMAHSYVEAFPDEEAAFRAFARAHPGPVTFLVDTYDSVRGVRTAARVLRDLGRGPGCAVRLDSGDLGDLARRARAELDRSGLPGVRVVASGGLDEYGVDTLVRSGAPIDVYAVGTRVGTSADAPYLDSAYKLVEYDGRPVMKLSSAKVTSPGRKQVFRRPGGDDVIALRDEPGPAGAEPLLRTVMRDGRRLGPPDTLPQGHARLTADLAGLPADAVRVRAPRPARAVFSERLSELTADLSDRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ02</accession>
    <name>Q9RJ02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0163</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36945">
        <property type="entry name" value="T36945"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624499.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026894.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0163"/>
    <dbReference type="GeneID" id="1095587"/>
    <dbReference type="KEGG" id="sco:SCO0163"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.136"/>
    <dbReference type="eggNOG" id="COG0645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026771_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RJ02"/>
    <dbReference type="OMA" id="FRFVDVM"/>
    <dbReference type="PhylomeDB" id="Q9RJ02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="508" mass="54731" checksum="EDDFC8DBC9C7303A" modified="2000-05-01" version="1">MAEPGGHEGPASTQRAKVCETHTAMVFFVEDRVYKRKKPVDLGFLDYTTRSSRRAVCEREIELNRRFAPDVYLGLGELRTPGEQEAEPLVVMRRMPDDRRLSHLVRTGAPVADDLRAVARHLAAWHSAAPRGPAIAEQGTRDALAARWEASFTQVDVLAAKGPTRDEAGEVERLVRRYLAGRKPLFGLRIEQGRVLDGHGDLLADDVFCLGDGPRILDCLEFDDALRYVDGLDDAAFLAMDLESLGAPESAAFFLAQYGEYSGDPAPPSLWHHYVAYRAFVRAKVSLIQARQGAPGAHATARRLVRMALRHLRASAVGLTLVAGLPGTGKSTLSGALADRLGAVLLSSDRLRKEMAGLSPQQTASADYGEGLYTPEWTARTYAELLDRAAALLALGESVVLDATWIDSAQREAARHTAESAGADLVALHCHVPDDVTAARLSTRAPGASDADLGVAEAMAAEEQPWSGAVGVDTGGSLEAAVGQALAAVRPWGSDQAKVFRRPYMEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ11</accession>
    <name>Q9RJ11_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0154</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36936">
        <property type="entry name" value="T36936"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624490.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026888.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0154"/>
    <dbReference type="GeneID" id="1095578"/>
    <dbReference type="KEGG" id="sco:SCO0154"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.130"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_5_2_11"/>
    <dbReference type="InParanoid" id="Q9RJ11"/>
    <dbReference type="OMA" id="AWCPYCN"/>
    <dbReference type="PhylomeDB" id="Q9RJ11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="23395" checksum="EE9282438B2C1C2B" modified="2000-05-01" version="1">MTTTPIADQAAVLAEGMADQTPSEALEAFGAEQAELDAAGVPSGIATAGSLMPDASLLDVHGNATTLQQVREGRPAVVVFYRGAWCPYCNLALRTYERELAPRLAERGVSMIAVSPQRPDGSLTMAQTNDLSYDVLSDPGNHIGRALGIVTRPTDRVQHAQASLGLDLTEVNADGTPDILMPTVAIVDAEGVLRWIDVHPNYVTRSEPARILEALARAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJM8</accession>
    <name>Q9RJM8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0616</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624928.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027248.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0616"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="GeneID" id="1096039"/>
    <dbReference type="KEGG" id="sco:SCO0616"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.597"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RJM8"/>
    <dbReference type="OMA" id="VHMADPH"/>
    <dbReference type="PhylomeDB" id="Q9RJM8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="310"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="726"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="606"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="791" mass="88626" checksum="0C15CAC744D2EB72" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJS3</accession>
    <name>Q9RJS3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0413</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624734.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027096.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0413"/>
    <dbReference type="GeneID" id="1095836"/>
    <dbReference type="KEGG" id="sco:SCO0413"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.389"/>
    <dbReference type="eggNOG" id="ENOG5031GWT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1271722_0_0_11"/>
    <dbReference type="OMA" id="AFANVWR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
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        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="21084" checksum="7A9AE94A2450FD97" modified="2000-05-01" version="1">MTTAHDLTIVSLEVPSDYPVERGDLSLALAGAELIDLMEAGTVELDGDLLRPVSRAASGDRLLDEAASLLGGDPAESVTDWLWRRGDGLAARYLAAAGADEGGRRRPRRNARGGTGRPAPADPAAHRRATDRWSGADPVLAGFAAAVGVRHESADQVADPEDDGVATVLAAVNDVVVELAAIRQRRSIEEAAFDNIWRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJV6</accession>
    <name>Q9RJV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding-protein-dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0354</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624677.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027046.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0354"/>
    <dbReference type="GeneID" id="1095777"/>
    <dbReference type="KEGG" id="sco:SCO0354"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.329"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="OMA" id="NDFMMPS"/>
    <dbReference type="PhylomeDB" id="Q9RJV6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB55716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="30243" checksum="8B2AF556AEC3DB43" modified="2000-05-01" version="1">MKKTLTSAATVRGAFVSLVSLGMLVPMYLLVVNAFKSQQEILANPFSPSFGTATFQYLADAWNNPDFSILKGYGVTIALVLCVNALAMAVCAPAAYVLARTPKPISRLLLFFFIAGMFIPTQVILVPVIFVLRGIGLMGTLPGLILFMTATTIPFTLFVFFGYIRVLPRSLDEAAAIDGAGRYRTLWRIILPLMRPIVATVFILNSLSVWNDFASPQMILGPGSGVYTVTTGVYAAVGQYSTDYTKVFPTLLLAVIPILVIFVVMQRHIMSGLAAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJW1</accession>
    <name>Q9RJW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible oxidoreductase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0349</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624672.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027041.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0349"/>
    <dbReference type="GeneID" id="1095772"/>
    <dbReference type="KEGG" id="sco:SCO0349"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.324"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_5_0_11"/>
    <dbReference type="InParanoid" id="Q9RJW1"/>
    <dbReference type="OMA" id="WVMIANS"/>
    <dbReference type="PhylomeDB" id="Q9RJW1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19162">
        <property type="entry name" value="AKR_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044477">
        <property type="entry name" value="FDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="334" mass="35440" checksum="81C43325E2DCD5B8" modified="2000-05-01" version="1">MRSRTLARGPVLTALGLGAAQLGNLARKTSDTDARGAVDAAWDSGVRYFDTAPHYGLGLSERRLGAALARRPRAEYTVSTKVGRLLVPSPETAHRQDDGGFAVPAAFRRDWDFSRDGILRSLEGSLTRLGLDHVDIVYLHDPDEHWQQASTTGVDTLVGLRDQGVVKAVGVGMNQAAMLAEFVRRSDVDLVMVAGRHTLLDQSAQDELLPLARERGVGVVAAAVYNSGLLAADRPPGDATYDYQPASRELIARADALADVCERHGVTLPEAAIAYPLRHPAVVSVVLGARDAGQSRTNAARLAAGVPNALWTELADLGLLPEVPGAPSTPGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK78</accession>
    <name>Q9RK78_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0532</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624846.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027185.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0532"/>
    <dbReference type="GeneID" id="1095955"/>
    <dbReference type="KEGG" id="sco:SCO0532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.512"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="InParanoid" id="Q9RK78"/>
    <dbReference type="OMA" id="IVWQSVP"/>
    <dbReference type="PhylomeDB" id="Q9RK78"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="302" mass="33279" checksum="79E18529A1212701" modified="2000-05-01" version="1">MPPGAAGRGTLWPYLLIAPAVLGMLYLLLYPLARAVLISFQDFRLRQLILGDADFVGLRNYRTLLGDPEFWEVVRRTFVFMAVGVVAIMVLSTLVALMTERLGRAARTVVLSSLVLVWAVPVVAATTVFQWLFHSEFGIVNETLTGLGFESYEGYPWFAHGGAAFGIVVVLIVWQSVPFAAITLYSALVTVPAELYESARMDGAGAARVFRSVTFPLIRPIFMLVLSLEVIWTFKAFVQIWVMTRGGPGEATTILPVYAVQTALAGQRYDLGSAASMLTVLLMSGVLVLYFRQLFRQEGEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKC2</accession>
    <name>Q9RKC2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627381.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975651.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3165"/>
    <dbReference type="GeneID" id="1098599"/>
    <dbReference type="KEGG" id="sco:SCO3165"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3225"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKC2"/>
    <dbReference type="OMA" id="PLPIYCD"/>
    <dbReference type="PhylomeDB" id="Q9RKC2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="18343" checksum="64AC19CC534E2B6D" modified="2000-05-01" version="1">MTTTDDASGPAATSGSAGASAAHPRFAAALGELGLGDLAGRARRFPEATRTAAEAAAAIGCELSQICKSLIFAADGVPVLVLMDGASRVDLDRVRDALGAGKVTRAKADVVRETTGYAIGGVPPFGHRTRTRVLADRSLLAHDVVWAAAGTPYAVFPMEPEDLVATAGATLVDVRERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKJ0</accession>
    <name>Q9RKJ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO4096</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="291"/>
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</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ8</accession>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
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                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
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        </location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKT3</accession>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
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                <person name="Quail M.A."/>
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                <person name="Chen C.W."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="28611" checksum="BC8FB725A7FA47AF" modified="2000-05-01" version="1">MTRNEDRTALVELSGVSKNYGNVRALEGVSLEVHAGEITCVLGDNGAGKSTLIKIIAGLHQHDGGTLSLDGEETRLSSPREALDRGIATVYQDLAVVPLMPVWRNFFLGSEPRKGVAPFKRMDVDHMRRTTHAELLRMGIDLRDVDQPIGTLSGGERQCVAIARAVYFGAKVLVLDEPTAALGVKQSGVVLKYVAAARDQGLGVVLITHNPHHAYLVGDRFVLLKRGTMVANQTRDEVTLDELTQQMAGGTELDDLRHELERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKT4</accession>
    <name>Q9RKT4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system sugar permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6258</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAB60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630358.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972668.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6258"/>
    <dbReference type="GeneID" id="1101699"/>
    <dbReference type="KEGG" id="sco:SCO6258"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6372"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_11"/>
    <dbReference type="OMA" id="SMFSYQM"/>
    <dbReference type="PhylomeDB" id="Q9RKT4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="346" mass="36534" checksum="4C014123B68850A8" modified="2000-05-01" version="1">MNATQVKAADERILQTSRLRKLLGRPELGSVVGAIAVFVFFAFFADSFLHAASLSTVLYAASTIGIMAVPVALLMIGGEFDLSAGVMVTSSALVSSMFSYQMTANVWVGVVVSLLVTLAIGAFNGFMLTRTKLPSFIITLGTFLMLTGLNLGFTKLVDGTVSTKSIADMEGFPSAQDVFASTITIGGVGFKVTILWWLALVAVASWILLRTRAGNWIFAVGGNKDAARAVGVPVAKTKIGLYMGVGFGAWISGQHLLFSYDVVQSGEGVGNELIYIIAAVIGGCLITGGYGSAVGSAVGAFIFGMTSKGIVFAEWNPDWFKFFLGAMLLLATLLNAWVRKRAEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKZ5</accession>
    <name>Q9RKZ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1437</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977388.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1437"/>
    <dbReference type="GeneID" id="1096863"/>
    <dbReference type="KEGG" id="sco:SCO1437"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1447"/>
    <dbReference type="eggNOG" id="ENOG50331K6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110740_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RKZ5"/>
    <dbReference type="OMA" id="TFRPTRT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="16662" checksum="3B403F2CC5E13447" modified="2000-05-01" version="1">MPDTTPDHLPALPVTFRPGRTRAVLIVLAIVTFVTVTALGMLLGGLGPGERVSFVLTALVLAGVLFLMARPRVDADETGVTVVNLTARRRLAWPEILRVNLRQGDPWVFLDLSDGTSLPALGIQPGIAKQQALADARALRDLVEARSGALPEAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1N8</accession>
    <name>Q9S1N8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0253</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-12" db="PDB data bank">
            <title>Structure of SCO0253, a Tetr-family transcriptional regulator from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Singer A.U."/>
                <person name="Xu X."/>
                <person name="Chang C."/>
                <person name="Gu J."/>
                <person name="Edwards A.M."/>
                <person name="Joachimiak A."/>
                <person name="Savchenko A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37168">
        <property type="entry name" value="T37168"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624585.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026962.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="PDB" id="3FIW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B/C/D=1-190"/>
    </dbReference>
    <dbReference type="PDBsum" id="3FIW"/>
    <dbReference type="SMR" id="Q9S1N8"/>
    <dbReference type="STRING" id="100226.SCO0253"/>
    <dbReference type="GeneID" id="1095677"/>
    <dbReference type="KEGG" id="sco:SCO0253"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.225"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_2_1_11"/>
    <dbReference type="OMA" id="MNRETVI"/>
    <dbReference type="PhylomeDB" id="Q9S1N8"/>
    <dbReference type="EvolutionaryTrace" id="Q9S1N8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB53293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="3FIW"/>
        </source>
    </evidence>
    <sequence length="190" mass="21074" checksum="6BC9E6477E49D442" modified="2000-05-01" version="1">MTKMNRETVITEALDLLDEVGLDGVSTRRLAKRLGVEQPSLYWYFRTKRDLLTAMAQAAMAPHAAEPLPEPGEDWHGWFLRNTRSFRRTLLARRDGARLHAGSRPTADLDRVRRKMDFLVASGVPERHAQMAMLAAGRFTVGCVLEEQAETGAGDTADLPADVPEIDHESAFEAGLALITDGLVRHVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1P2</accession>
    <name>Q9S1P2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0249</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37164">
        <property type="entry name" value="T37164"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624581.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026958.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0249"/>
    <dbReference type="GeneID" id="1095673"/>
    <dbReference type="KEGG" id="sco:SCO0249"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.221"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_1_11"/>
    <dbReference type="InParanoid" id="Q9S1P2"/>
    <dbReference type="OMA" id="MYIGYVG"/>
    <dbReference type="PhylomeDB" id="Q9S1P2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="504" mass="53721" checksum="263288FF3E478F8A" modified="2000-05-01" version="1">MSTDVIVVGAGPTGLMLACELALAGVRTRVLERRTEPQRDSRALSLHPRSVELMDQRGLLDRFLPLGRAVPGWHFAGLRTQLDFSALDSRHGYTLFLAQARTEAILERRAHELGVEISRGHEVLGVRQDGDGVEVEVRAPGGGTETAHSLYAVGCDGGRSIVRQAAGIGFPGTDETLTGVLGDFAVVDPQPGALAAARAGGVIVAPLEGGVTRFVYLDPERIRVPAREPVSLEEFRTSLTRITGSDCGVAEPVWLSRFGNATRLAESYRSGRILLAGDAAHIHFPAAGQGLNTGLQDAMNLGWKLAAVVGGWAPPGLLDGYDGERRPVGRSVTENTEVQTLLAELTLVAQYRRPAEALRRLLDQLLGMAEVNRRLADQVSALGTGYPPPDPGADPLVGRRMPDVGLTAAGSEATRVYELLHGGRFVLLSLAGDPALRESVDAGWGPRVTAVAVDKYDEHPDLDGVTEVLVRPDGHVAWATRTTDGGARDDQRARALTAWAGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S253</accession>
    <name>Q9S253_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1699</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36800">
        <property type="entry name" value="T36800"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625973.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977126.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S253"/>
    <dbReference type="STRING" id="100226.SCO1699"/>
    <dbReference type="GeneID" id="1097130"/>
    <dbReference type="KEGG" id="sco:SCO1699"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1717"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_11"/>
    <dbReference type="InParanoid" id="Q9S253"/>
    <dbReference type="OMA" id="RSFVRWH"/>
    <dbReference type="PhylomeDB" id="Q9S253"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB46797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23123" checksum="50A8A4E3450D111E" modified="2000-05-01" version="1">MSTAAETTGGDIEPWEEVTPDAARRLLVAAVEAFAERGYHATTTRDIAGRAGMSPAALYIHYKTKEELLHRISRIGHTRAVAILRSAAQGEGSAAERLADAVSSFVRWHAGRRTTARVVQYELDALGPEAREEILTLRRQCDAAVRGIIDDGVAAGEFDVPDVKGTTLAVLSLCIDVARWFNVNGPRTPDEVGALYADLVLRMVGAEPSGATAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S256</accession>
    <name>Q9S256_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1696</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36797">
        <property type="entry name" value="T36797"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625970.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027925.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1696"/>
    <dbReference type="GeneID" id="1097127"/>
    <dbReference type="KEGG" id="sco:SCO1696"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1714"/>
    <dbReference type="eggNOG" id="COG3246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098986_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S256"/>
    <dbReference type="OMA" id="NWHEPGA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="25147" checksum="688011266620DF5F" modified="2000-05-01" version="1">MQLCVNGARTSADGAVVPLSPEAVADSVAEAVAAGATDVHVHPKTPCGRDTLSPRVLAATLEAIRARVPASVPVGVTTGAWAEPGPAARVARIRSWTALPDHASVNWHEPGAEEVAAALIERGVAVEAGIWSGTEGAALFRRSPLGPRVLRVLAEVTDPDPAAARDSAHALLARLGTAHGRPVLLHGEEGGAWPVLRLAGRLGLATRIGLEDTLRLPDGGWAASNAELVTAGTREWAAARRGHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2F4</accession>
    <name>HPPD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>4-hydroxyphenylpyruvate dioxygenase</fullName>
            <shortName>4HPPD</shortName>
            <shortName>HPD</shortName>
            <shortName>HPPDase</shortName>
            <ecNumber>1.13.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hpd</name>
        <name type="ordered locus">SCO2927</name>
        <name type="ORF">SCE19A.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36150">
        <property type="entry name" value="T36150"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627153.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975883.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2F4"/>
    <dbReference type="SMR" id="Q9S2F4"/>
    <dbReference type="STRING" id="100226.SCO2927"/>
    <dbReference type="GeneID" id="1098360"/>
    <dbReference type="KEGG" id="sco:SCO2927"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2985"/>
    <dbReference type="eggNOG" id="COG3185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034004_1_1_11"/>
    <dbReference type="InParanoid" id="Q9S2F4"/>
    <dbReference type="OMA" id="DPFPVKG"/>
    <dbReference type="PhylomeDB" id="Q9S2F4"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="chain" id="PRO_0000088410" description="4-hydroxyphenylpyruvate dioxygenase">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="VOC 1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VOC 2" evidence="2">
        <location>
            <begin position="184"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="381" mass="41876" checksum="326B241FF9BAC49E" modified="2000-05-01" version="1">MTQTTHHTPDTARQADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMKLVAYSGPENGSRETASYVLESGSARFVFTSVIKPSTDWGTFLAQHVAEHGDGVVDLAIEVPDARAAHAYAVEHGARSLAEPHEVKDEHGTVVLAAIATYGETRHTLVERTGYDGPYLPGYVAAKPMVAPPAQRVFQAVDHCVGNVELGRMNEWVGFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKVKFPINEPAIAKKKSQIDEYLEFYGGAGVQHIALNTNDIVATVRAMRAAGVEFLDTPDSYYDTLGEWAGETRVPVDVLRELKILVDRDEDGYLLQIFTKPVQDRPTVFFEMIERHGSMGFGKGNFKALFEAIEREQEKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Q4</accession>
    <name>Q9S2Q4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2182</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35298">
        <property type="entry name" value="T35298"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626435.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976633.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2182"/>
    <dbReference type="GeneID" id="1097615"/>
    <dbReference type="KEGG" id="sco:SCO2182"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2220"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_11"/>
    <dbReference type="InParanoid" id="Q9S2Q4"/>
    <dbReference type="OMA" id="VLLHTWE"/>
    <dbReference type="PhylomeDB" id="Q9S2Q4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB51266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="207" mass="23038" checksum="462BC5A09919D375" modified="2000-05-01" version="1">MTAPVVHSLREQIREHILEGIISGRWQPGERIVERRIATELEVSQTPVREALRELESLRLIESAPNKGVRVRNLTAADLEESYPVRAGLEAIAAELAADRLALDCSALEPHVAALYEADRVSDGTGQVRHTVGFHRELVRAAGNSVLLHTWEGLGIEVFTALSIRWLGTVQQSYAEEHEELVAAFRRRDPRIPEIVKSHVLGCAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Q1</accession>
    <name>Q9X7Q1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6745</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35270">
        <property type="entry name" value="T35270"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6745"/>
    <dbReference type="GeneID" id="1102184"/>
    <dbReference type="KEGG" id="sco:SCO6745"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6852"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061724_0_0_11"/>
    <dbReference type="OMA" id="AYWHAAT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="30785" checksum="79E0DD9ABE817091" modified="1999-11-01" version="1">MRGMTTAAIDARAGRRCHNALNSLHSTHYFSPDLGRELGGLGVTEAPAVNFAARAAALGPVGAGAVTAAFYNYKHELVARHVPAVWEKVTPEQALAARLRAVDATLRRLLGEEAVASAGMAEAAELALRAAEGCTRSGRPLYSAHADLPAPDAPHLALWHAATLLREHRGDGHLATLMTAGLDGLEALVTHTATGKGMAPKWIFTTRGWTQEEWDAAAGRLRERGLVDAAGGLTEEGTALREGIERETDRLDTAPYAHLGAEDVARLTELASGFARTALGAGAFPADLLARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-09-26" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7R9</accession>
    <name>CLPP3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 3</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP3</name>
        <name type="ordered locus">SCO7281</name>
        <name type="ORF">SC5H1.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35327">
        <property type="entry name" value="T35327"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631337.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971862.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X7R9"/>
    <dbReference type="SMR" id="Q9X7R9"/>
    <dbReference type="STRING" id="100226.SCO7281"/>
    <dbReference type="MEROPS" id="S14.008"/>
    <dbReference type="GeneID" id="1102719"/>
    <dbReference type="KEGG" id="sco:SCO7281"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7383"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_4_1_11"/>
    <dbReference type="InParanoid" id="Q9X7R9"/>
    <dbReference type="OMA" id="GIFDTMQ"/>
    <dbReference type="PhylomeDB" id="Q9X7R9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179666" description="ATP-dependent Clp protease proteolytic subunit 3">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="217" mass="23561" checksum="1932DD598AA47AA2" modified="1999-11-01" version="1">MSPFTAGPAPARTPRAEEGDTPATRFDDRLAEQLLDQRIVLLGTQVDEVSANRVCAQLLILSAQDPRTDISLYVNSPGGSVHAGLAIYDTMRLIPNDVSTLAMGFAASMGQFLLSVGTAGKRYALPNARIMMHQPSAGIGGTTADIEIQADNLDFTKRTIERITAEHTGQSPETISRDGDRDRWFTAEEAREYGMVDQVVQSLADVRPAATRRRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7V2</accession>
    <name>Q9X7V2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6757</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35397">
        <property type="entry name" value="T35397"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630829.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972239.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6757"/>
    <dbReference type="GeneID" id="1102196"/>
    <dbReference type="KEGG" id="sco:SCO6757"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6866"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_4_0_11"/>
    <dbReference type="InParanoid" id="Q9X7V2"/>
    <dbReference type="OMA" id="FVMRTWM"/>
    <dbReference type="PhylomeDB" id="Q9X7V2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="60"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB39690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="34099" checksum="B6AC08B83D74CDD6" modified="1999-11-01" version="1">MSETTHDGTVAMTKPVSPDEGLTPARLAAKYGLSVSGARPSLKEYVRQLWGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNALVYFLIFGLILDAGRGMEKDVYIPFLVTGVFVFTFTQSSAMAGVRAIAGNLGLVRALHFPRASLPVSFALQQLQQLLASMIVLFLVVVGFGSYPSLSWLLVLPVLVLQFLFNTGLALVVARMGAKTPDLAQLMPFIMRTWMYASGVMFSIPIMLKDKPDWIADVLQWNPAAVYMDLMRFALIDGYGSENLPPHVWAVALGWAVVLAVGGFVYFWKAEERYGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8D1</accession>
    <name>Q9X8D1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3258</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36218">
        <property type="entry name" value="T36218"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627470.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028865.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3258"/>
    <dbReference type="GeneID" id="1098692"/>
    <dbReference type="KEGG" id="sco:SCO3258"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3322"/>
    <dbReference type="eggNOG" id="ENOG502ZJD9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159294_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="118" mass="12401" checksum="755979398E88CF33" modified="1999-11-01" version="1">MRQIPVDTSAATVMVAKTPQPKVRDRRTGEIATDAETGAKLMTVDVMFAANDEVEILSVTVPETGISGDLTMGTPAALTGLVARPWENEFNGQKRHGIAFRAVAVTSLATTDTGSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8X4</accession>
    <name>Q9X8X4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3692</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36627">
        <property type="entry name" value="T36627"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627884.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029168.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3692"/>
    <dbReference type="GeneID" id="1099128"/>
    <dbReference type="KEGG" id="sco:SCO3692"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3750"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="InParanoid" id="Q9X8X4"/>
    <dbReference type="OMA" id="MEFCDSS"/>
    <dbReference type="PhylomeDB" id="Q9X8X4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB44395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="12696" checksum="BD1BF664247B3207" modified="1999-11-01" version="1">MSKYLTVRVRTGTAGAVIELTGELDHHTAADVRDTLPGLGLQPGQQLVLDLAGLTFLDSTGLTVLIAARNHALATDATIALAAVPDRVSRIIRVLGLNQFFPTHPTAQDADTAWQSEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Y2</accession>
    <name>Q9X8Y2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative heavy metal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36635">
        <property type="entry name" value="T36635"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627892.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029173.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3700"/>
    <dbReference type="GeneID" id="1099136"/>
    <dbReference type="KEGG" id="sco:SCO3700"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3760"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_11"/>
    <dbReference type="InParanoid" id="Q9X8Y2"/>
    <dbReference type="OMA" id="VISLCGC"/>
    <dbReference type="PhylomeDB" id="Q9X8Y2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14620" checksum="F4B4D43B94CE4C2B" modified="1999-11-01" version="1">MPDKPSVLFVCVHNAGRSQMAAAWLTHLAGDRVEVRSAGSNPGENVNPAAVEAMREVGIDISAEVPKMLTVDAVKESDVCITMGCGDTCPVFPGKRYLDWQLADPAGQGVAAVRPIRDEIRVLVEGLVKEIAPRPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA23</accession>
    <name>Q9XA23_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3841</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36710">
        <property type="entry name" value="T36710"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628029.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029264.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3841"/>
    <dbReference type="GeneID" id="1099277"/>
    <dbReference type="KEGG" id="sco:SCO3841"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3911"/>
    <dbReference type="eggNOG" id="COG4320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032121_0_0_11"/>
    <dbReference type="OMA" id="RQFRNRK"/>
    <dbReference type="PhylomeDB" id="Q9XA23"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="509" mass="53084" checksum="0FE5C5549531FF09" modified="1999-11-01" version="1">MTGATAGTGTETATGETATGEAATRVVPVARADGGGGGGAEPTAGAARGGRVPYVPGFARWPVAGSPKAEGKALRTRVPRSAHATLGLDAARPDAVSAVEESSRGRIPGLAPIRAGRMAATPFAFLRGSAGLMAYDLAHTPVTGIGAQICGDAHAANFGLYGDARGGLVIDLNDFDETVHGPWEWDLKRLAASLVLAGREAGADEDTCREAAHDAAGAYRRTMRLLARLPALDAWNAIADEELVSHTDAHDLLGTLERVSEKARSNTSGRFAAKSTEPTGDGGRRFVDAAPVLRRVTDAEAAAVAGALEAYPATLSEDRLPLLARYAVHDVAFRVVGTGSVGTRSYVVLLLDHRGEPLVLQVKEARPSALLPHLAAAGFEAPEAAHEGRRVVMGQKRMQVVSDILLGWTSVDGRPFQVRQFRNRKGSVDPAALAADQLDDYGRMTGALLARAHAHSADPRTVAGYCGKNDELDEAVAVFAVAYADRTEADHAELVGAVRTGRIAAELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA66</accession>
    <name>Q9XA66_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO3811</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36492">
        <property type="entry name" value="T36492"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628000.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029243.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3811"/>
    <dbReference type="MEROPS" id="S11.004"/>
    <dbReference type="GeneID" id="1099247"/>
    <dbReference type="KEGG" id="sco:SCO3811"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3879"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_7_0_11"/>
    <dbReference type="InParanoid" id="Q9XA66"/>
    <dbReference type="OMA" id="TNEAKYC"/>
    <dbReference type="PhylomeDB" id="Q9XA66"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177038" evidence="9">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="52"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="32763" checksum="E95F97E566BFABE0" modified="1999-11-01" version="1">MNAIPGATASVRPRRALAAVLTGAAVLATGVLATAPAQAAAPDRALAAPVRAAAVPSIAARGGFVMNNATGRSLYTKAADTRRSTGSTTKIMTAKVVLSQPKLNLDAKVTIQMAYSDYIVSKNASSARLIVGDKVTVRQLLYGLMLPSGCDAAYALADKFGSGRTRAARVKSFIGKMNATAKSLGLKNTHFDSFDGIGNGKNYSTPRDLTKIASSAMKNSTFRTIVKTKKYTAKTRTKKGGTRTMAPWTNTNTLLGSYSGAIGVKTGSGPEAKYCLVFAATRKGKTVIGTVLASSSSAQRAKDATKLMNYAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAJ6</accession>
    <name>Q9XAJ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3606</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35374">
        <property type="entry name" value="T35374"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627801.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975333.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3606"/>
    <dbReference type="GeneID" id="1099042"/>
    <dbReference type="KEGG" id="sco:SCO3606"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3664"/>
    <dbReference type="eggNOG" id="COG3835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039160_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAJ6"/>
    <dbReference type="OMA" id="VYFDAGC"/>
    <dbReference type="PhylomeDB" id="Q9XAJ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="291"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="360" mass="39075" checksum="720E851AF35BA95D" modified="1999-11-01" version="1">MTDLQTEQWETYLAGYAEILAGVADTGRRLTRDELEERRLFGEQAAEAGHSLRSLVRLHLDATRTSWPGRGATVSGADATGTVLAAVAQAVDAFAEGYERAQRLAVRQEEAARREFIDDLLYGRSDLGRLAERAERFGLVLSHAHAVAVAQGPEAYDDTAPVTRVVESALISRFGDRRVLITTKNGQLICIAPGDQDEVLTFFAKQAYAATDGNRVAVGRPQSGAGGVVHSYEEALTTLELADRLGLEEPVVRAADMLVYPVLARDRQAMADLVLSVLGPLREARGGAEPLLRTLEVYFDAGCTAAEAARRLTLSVRALTYRLDRIHQLTGANASDPVHRYTLQTAVIGARLLGWPAQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAL0</accession>
    <name>Q9XAL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3592</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35360">
        <property type="entry name" value="T35360"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627787.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029107.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3592"/>
    <dbReference type="GeneID" id="1099028"/>
    <dbReference type="KEGG" id="sco:SCO3592"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3648"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058628_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAL0"/>
    <dbReference type="OMA" id="FWTDSRD"/>
    <dbReference type="PhylomeDB" id="Q9XAL0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="34963" checksum="94CDE924DF1B740F" modified="1999-11-01" version="1">MVLRSAARPELWKRAPVLTVSALLLGLVMMLHAEIPNRFGSVGSLVETFLPWFGLFVPVLAAGALWRRSAAAVTALVLPVTVWLSLFGGLLGDKSGAGGEFTMASHNVGAENPDPAGTARDLAASGVDVLALEEITAQDREVYEKGLAREYPYHTVQGTVGLWSKLPLSGTRPVDIATDYGPLADTKPADVTMAGNRALRTTVATERGPLVVYVAHLGSVRLNPRAGFWTDSRDRNAWALGEALAADRSERIALLGDLNGTVDDRALAGITSQLHSVQEAAGNGFGFTWPAKFPVARIDQILVRGVEPTGSWTLPATGSDHLPVAAGVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAP3</accession>
    <name>Q9XAP3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4551</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34635">
        <property type="entry name" value="T34635"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628713.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029727.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4551"/>
    <dbReference type="GeneID" id="1099991"/>
    <dbReference type="KEGG" id="sco:SCO4551"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4623"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102958_0_0_11"/>
    <dbReference type="OMA" id="EQAYHPD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="20587" checksum="DE694AD997E9B279" modified="1999-11-01" version="1">MLRIHVCEASPEAAVVVDGARLAAVGPYEALAADHPRARVRRWPGILTPGLLNPYGPELLEQAYHPDPREADRLGTEPIFGQRALALLGAQASARGASARRGVQRMLAHGTVAVAGELRGRAALDAVRGAGLALAGRPATLPGPASLSPVPLVLLPALAAGKPARFAVFDVPDRAALVREGASTCVATVVGGRLVYRGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z596</accession>
    <name>Y6206_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative hydroxypyruvate isomerase</fullName>
            <ecNumber>5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO6206</name>
        <name type="ORF">SC2G5.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34860">
        <property type="entry name" value="T34860"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630309.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972721.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z596"/>
    <dbReference type="SMR" id="Q9Z596"/>
    <dbReference type="STRING" id="100226.SCO6206"/>
    <dbReference type="PRIDE" id="Q9Z596"/>
    <dbReference type="GeneID" id="1101647"/>
    <dbReference type="KEGG" id="sco:SCO6206"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6320"/>
    <dbReference type="eggNOG" id="COG3622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_1_0_11"/>
    <dbReference type="InParanoid" id="Q9Z596"/>
    <dbReference type="OMA" id="CEYRPRA"/>
    <dbReference type="PhylomeDB" id="Q9Z596"/>
    <dbReference type="BRENDA" id="5.3.1.22">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000209112" description="Putative hydroxypyruvate isomerase">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9WYP7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="279" mass="29635" checksum="18010C6C3A755D73" modified="1999-05-01" version="1">MGFADQRFNVNLSILFTELPLLERPAAAAAAGFTAVELWWPWIDSPTPEQSELDALKSAIEDAGVQLTGLNFYAGQLPGPDRGALSIPGEESERFRANIDVAADFARSLGCTALNALYGNRVEGVDPAEQDRLALENLVLAARAADRIGAVLLVEALNKPESPRYPLVSAPAAIAVVDRVNEATGLGNAKFLMDLYHLSMNGEDLPQVIDAYAAKTGHVQIADNPGRGAPGTGSLPLEDLLDRLAKAGYDGWVGLEYKPGDDPSAQSFSWLPAGARAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5B8</accession>
    <name>Q9Z5B8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34838">
        <property type="entry name" value="T34838"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630287.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030720.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6184"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1101625"/>
    <dbReference type="KEGG" id="sco:SCO6184"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6294"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075562_0_0_11"/>
    <dbReference type="OMA" id="VHGSWTT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB36592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="35283" checksum="27A03B8B908A5EF3" modified="1999-05-01" version="1">MRILMWHVHGSWTTAFVQGPHTYLVPVTPDRGPDGLGRARTWDWPESVVEVPPERLRDEDIDLVILQRPHELDLVDRWLGRRPPLVYLEHNAPDGDVPRTRHPAADVPGVTLVHVTHFNRLMWDAGPTHSTVVEHGIVDPGHRWTGELERAAVVVNEPIRRGRTTGTDLLPVFSRAAPLDVFGMRTEGLAEHLGVDPGRCRTRDVPQSELHTELARRRVYVHPVRWTSLGLSLLEAMHLGMPVVALATTEVTEAVPPGAGVVSNRIDVLTDAVRDFLADPPHARAVGEAARAAALAHYGLPRFLDDWERLLKEVTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBI5</accession>
    <name>Y6489_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative carboxypeptidase SCO6489</fullName>
            <ecNumber>3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO6489</name>
        <name type="ORF">SC9C7.25</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35976">
        <property type="entry name" value="T35976"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630572.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030959.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBI5"/>
    <dbReference type="SMR" id="Q9ZBI5"/>
    <dbReference type="STRING" id="100226.SCO6489"/>
    <dbReference type="MEROPS" id="S66.001"/>
    <dbReference type="PRIDE" id="Q9ZBI5"/>
    <dbReference type="GeneID" id="1101928"/>
    <dbReference type="KEGG" id="sco:SCO6489"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6590"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_3_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBI5"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="PhylomeDB" id="Q9ZBI5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000172845" description="Putative carboxypeptidase SCO6489">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="310" mass="32764" checksum="6E2C587F3AE8E615" modified="1999-05-01" version="1">MRELVRPARLAPGARVAVVAPSGPVPEERLQAGLDVLRGWDLDPVVAPHVLDRHDTFDYLAGTDADRAADLQAAWCDPAVDAVLCARGGYGVQRMADLLDWEAMRAAGPKVFVGFSDITALHEAFATRLGLVTLHGPMAAGIDFIKNARAQEHLRATLFAPETVRVITSGGTPLVPGRARGVTLGGCLALLAADLGTPHARPGARGGLLCLEDVGEETYRIDRYLTQLLRSGWLDGVGGVLLGSWAQCEPYERLRPLLADRLGGLGVPVVEDFGFGHCEGALTVPFGVPAELDADTGTLTLDRPALCSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBJ4</accession>
    <name>Q9ZBJ4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35967">
        <property type="entry name" value="T35967"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630563.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030953.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6480"/>
    <dbReference type="GeneID" id="1101919"/>
    <dbReference type="KEGG" id="sco:SCO6480"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6581"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154488_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBJ4"/>
    <dbReference type="OMA" id="IWVTEVW"/>
    <dbReference type="PhylomeDB" id="Q9ZBJ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="99" mass="10739" checksum="6CEC5FA8CC4ACC53" modified="1999-05-01" version="1">MTYGCIASMKTRPGFREEVVSLLLSAADGLRDAGCELYVVGLSEDDETTIWVTEVWRTREDHDASLELPAAKDAIGRAMPMLTGEFTKQEMSVAGGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBY0</accession>
    <name>Q9ZBY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3952</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36058">
        <property type="entry name" value="T36058"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628136.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029337.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3952"/>
    <dbReference type="GeneID" id="1099388"/>
    <dbReference type="KEGG" id="sco:SCO3952"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4024"/>
    <dbReference type="eggNOG" id="ENOG5033X3K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1739568_0_0_11"/>
    <dbReference type="OMA" id="HEAHVEF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA22224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="16665" checksum="343DA7B5FB7C6323" modified="1999-05-01" version="1">MIEGMEHLPTTQSAVTALRAVAEEYALEIEVTDDIGADQTSRHSAAGVGVTTDADDSLPHEAFVEFGGVPRVSVRLFHEGDALLTVENVEFPDVERDDVPAFLRSVFGGLAYVQGRRFPPGYRLIVPLPGDRAHKEHVSMLLLTPWLSSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-05-25" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O54138</accession>
    <name>O54138_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative turgor pressure regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5872</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34824">
        <property type="entry name" value="T34824"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629994.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973149.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="SMR" id="O54138"/>
    <dbReference type="STRING" id="100226.SCO5872"/>
    <dbReference type="GeneID" id="1101314"/>
    <dbReference type="KEGG" id="sco:SCO5872"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5971"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="InParanoid" id="O54138"/>
    <dbReference type="OMA" id="KARKYEV"/>
    <dbReference type="PhylomeDB" id="O54138"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA16481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="25399" checksum="346B7B9BB59B4886" modified="1998-06-01" version="1">MTRVLVIDDEPQIVRALVINLKARHYEVDAAHDGATALQLAAARHPDVVVLDLGLPDMDGVEVIRGLRGWTRVPILVLSARHSSDEKVEALDAGADDYVTKPFGMDELLARLRAAVRRAEPVPGGEDEVVVDTPEFTVDLAAKKVNRGGRDVRLTPTEWHLLEVLVRNTGRLVSQKQLLQEVWGPSYGTETNYLRVYMAQLRRKLEADPAHPRHFITEPGMGYRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O54182</accession>
    <name>O54182_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5953</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35718">
        <property type="entry name" value="T35718"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630070.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030559.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5953"/>
    <dbReference type="GeneID" id="1101395"/>
    <dbReference type="KEGG" id="sco:SCO5953"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6050"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014301_0_0_11"/>
    <dbReference type="InParanoid" id="O54182"/>
    <dbReference type="OMA" id="CERITYN"/>
    <dbReference type="PhylomeDB" id="O54182"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015032">
        <property type="entry name" value="MTH538_TIR-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08937">
        <property type="entry name" value="DUF1863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="506"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="795"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA16210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="913" mass="96133" checksum="E06EA81D22875553" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O68608</accession>
    <name>TRPD1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase 1</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD1</name>
        <name type="ordered locus">SCO2147</name>
        <name type="ORF">SC6G10.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="32" first="869" last="880">
            <title>The expression of the trpD, trpC and trpBA genes of Streptomyces coelicolor A3(2) is regulated by growth rate and growth phase but not by feedback repression.</title>
            <authorList>
                <person name="Hu D.S.-J."/>
                <person name="Hood D.W."/>
                <person name="Heidstra R."/>
                <person name="Hodgson D.A."/>
            </authorList>
            <dbReference type="PubMed" id="10361288"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01407.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="AF052077">
        <property type="protein sequence ID" value="AAC17870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35529">
        <property type="entry name" value="T35529"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626403.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028166.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O68608"/>
    <dbReference type="SMR" id="O68608"/>
    <dbReference type="STRING" id="100226.SCO2147"/>
    <dbReference type="PRIDE" id="O68608"/>
    <dbReference type="GeneID" id="1097581"/>
    <dbReference type="KEGG" id="sco:SCO2147"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2182"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_4_1_11"/>
    <dbReference type="InParanoid" id="O68608"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="PhylomeDB" id="O68608"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154489" description="Anthranilate phosphoribosyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <sequence length="354" mass="37018" checksum="816077E0007462BF" modified="1998-08-01" version="1">MSAVTPAGGDTTADRSWPALLNGLLDGRDLSADDTAWALDVIMRGEATDVQIAGFAVGLRFKGETVEEISGLVRTMYEHANVIEVPGKTVDIVGTGGDGAKTVNISTMSAIVLAGTGAKVVKHGNRAASSASGASDVLEKLGVNLELTPQRVAEVAEEAGITFCFAVKFHPALRHVATARGQLGIRTVFNFLGPLTNPARVKAQAVGVAHARMAPIVAGVFAERGHSSLVFRGDDGLDELTTTSTSRVWVVRDGRVTEETFDPRDVGIELVPVEALRGADASYNADVARRLLAGEKGPVRDAVLLNSAAALEALEPGEGALAERLRAGMDRAAEAIDSGAARRVLERWVAVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>O69848</accession>
    <name>O69848_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6018</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34698">
        <property type="entry name" value="T34698"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030598.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6018"/>
    <dbReference type="GeneID" id="1101459"/>
    <dbReference type="KEGG" id="sco:SCO6018"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6117"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063456_0_0_11"/>
    <dbReference type="OMA" id="WWTESGP"/>
    <dbReference type="PhylomeDB" id="O69848"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="35641" checksum="9C7DF3F315442D04" modified="1998-08-01" version="1">MNGDWLLLGRDGRLSVYFQTDDAALWRAESTPGGGWEPPRRAGGDQELRPGALAVGQGADGYAHLAAWQPIGADRAGLVHTTHYRPLLAPLDWQPAGHPNKQGDRTGPPTVAVDAQGRAHVFVRNGGGGMSMVAQREKGGWAPWRDLKGSRVQESPVAVTTRTGLVELYAPVESGILHWRQEAAGTRMELGERLQAAVRPGSLRALATSAERTTVFFTDDDTGELCAWRPGGKPAPLVPAAGPGPVSAVGTVIDGYDCTLLAQRAAGSGRVAFAAYPSEAEEAGAAWTESGPALPADATVALALDADGRLVAATLSPSTGQLLLTRRKDEAGLALGAWQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O69956</accession>
    <name>O69956_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5780</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35100">
        <property type="entry name" value="T35100"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629904.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030449.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5780"/>
    <dbReference type="GeneID" id="1101222"/>
    <dbReference type="KEGG" id="sco:SCO5780"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5870"/>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033215_4_1_11"/>
    <dbReference type="InParanoid" id="O69956"/>
    <dbReference type="OMA" id="TTGVYFP"/>
    <dbReference type="PhylomeDB" id="O69956"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="331" mass="35821" checksum="8172B936D78F8000" modified="1998-08-01" version="1">MSTLLSRIGRRRAVQGTVAGAVVLGLLLWWLLPLGEKPPSGTITFSTGTRAGVYQKYGELLRTELRKDMPGLDVRLMTSAGSQENVERVASGEADFTIAAADAVETYKLAGSPGAEGLRGVTRLYDDYVQLVVPSDSDIQSVRDLRGKRVAIGLPNSGVRLIATRLLKAVGIDPETDITPRADGIDTGPGRLGDELDAFFWSGGVPTDGLKEIAESSAFRFVPIGDDLVTKLHRSGGATRYYRTTNMPESAYPTVQNGAVVPTMAVSNLLVTRADVDPRLTEWLTRTVLDSRDGIGAHVHSAQLVDLRTAIYTDPLELHEGARRYYRSVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O70009</accession>
    <name>O70009_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5833</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35207">
        <property type="entry name" value="T35207"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629956.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973188.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5833"/>
    <dbReference type="GeneID" id="1101275"/>
    <dbReference type="KEGG" id="sco:SCO5833"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5930"/>
    <dbReference type="eggNOG" id="ENOG50344V5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157310_1_0_11"/>
    <dbReference type="OMA" id="PLPDARC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8372" checksum="3AE3E801E61C8E39" modified="1998-08-01" version="1">MKIVRRIGVPPSARGSTTGSTCPDLFELSDGNFAVIGTEATEALERELPADAARADYERIVVISRETLIRAKADIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O86499</accession>
    <name>O86499_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34645">
        <property type="entry name" value="T34645"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630424.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030832.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6331"/>
    <dbReference type="GeneID" id="1101772"/>
    <dbReference type="KEGG" id="sco:SCO6331"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6443"/>
    <dbReference type="eggNOG" id="COG4320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032121_0_0_11"/>
    <dbReference type="OMA" id="QFRDMKD"/>
    <dbReference type="PhylomeDB" id="O86499"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="469" mass="52166" checksum="A9D619820B16389A" modified="1998-11-01" version="1">MTVPGGFTASLPPAERAAYGRKARKRASRSCHGWYEPGQRRPDPVDLLERQSGERVPALVPIRYGRMLESPFRFYRGAAAIMAADLAPLPSSGLQVQLCGDAHPLNFRLLASPERRLVFDINDFDETLPGPFEWDVKRLAAGFVIAARSNGFSSKEQNRTVRACVRAYRERMREFAVMPTLDIWYAQDDADHVRQLLATEARGEAEQRLRDAAAKARTRTHMRAFAKLTRVTAEGRRITPDPPLITPLGDLLTDPAEAGREEELRSVVNGYARSLPPERRHLLRHYRLVDMARKVVGVGSVGTRCWVLLLLGRDDDDPLLLQAKEASESVLAAHTGGERYDHQGRRVVAGQRLIQTTGDIFLGWARVTGFDGKARDFYVRQLWDWKGVARPETMGPDLLSLFARLCGACLARAHARSGDPVALAAYLGGSDRFDGALTEFAQSYADQNERDHEALLAACRSGRVTAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O86592</accession>
    <name>O86592_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6227</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37225">
        <property type="entry name" value="T37225"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630328.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030750.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6227"/>
    <dbReference type="GeneID" id="1101668"/>
    <dbReference type="KEGG" id="sco:SCO6227"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6341"/>
    <dbReference type="eggNOG" id="COG4264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018283_1_0_11"/>
    <dbReference type="InParanoid" id="O86592"/>
    <dbReference type="OMA" id="VRITNDI"/>
    <dbReference type="PhylomeDB" id="O86592"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="142"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="370"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="517" mass="55781" checksum="C19CD622859E7D76" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>P40170</accession>
    <name>DNAJ1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ1</name>
        <name type="ordered locus">SCO3669</name>
        <name type="ORF">SCH44.09c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Microbiol." volume="17" first="663" last="674">
            <title>The dnaK operon of Streptomyces coelicolor encodes a novel heat-shock protein which binds to the promoter region of the operon.</title>
            <authorList>
                <person name="Bucca G."/>
                <person name="Ferina G."/>
                <person name="Puglia A.M."/>
                <person name="Smith C.P."/>
            </authorList>
            <dbReference type="PubMed" id="8801421"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1995.mmi_17040663.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="DNA Seq." volume="6" first="179" last="184">
            <title>Cloning and sequencing of the dnaK locus in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Brans A."/>
                <person name="Loriaux A."/>
                <person name="Joris B."/>
                <person name="Dusart J."/>
            </authorList>
            <dbReference type="PubMed" id="8722574"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-387</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="L46700">
        <property type="protein sequence ID" value="AAB29453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB91160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X77458">
        <property type="protein sequence ID" value="CAA54608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S41948">
        <property type="entry name" value="S41948"/>
    </dbReference>
    <dbReference type="PIR" id="S70206">
        <property type="entry name" value="S70206"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627862.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975270.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40170"/>
    <dbReference type="SMR" id="P40170"/>
    <dbReference type="STRING" id="100226.SCO3669"/>
    <dbReference type="GeneID" id="1099105"/>
    <dbReference type="KEGG" id="sco:SCO3669"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3727"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_6_11"/>
    <dbReference type="InParanoid" id="P40170"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="PhylomeDB" id="P40170"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
        <property type="term" value="P:chaperone cofactor-dependent protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000070898" description="Chaperone protein DnaJ 1">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="232"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="166"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB29453." evidence="2" ref="1">
        <original>D</original>
        <variation>H</variation>
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="399" mass="41337" checksum="4C7A3412B61B3F12" modified="2000-12-01" version="2">MSTKDFIEKDYYKVLGVPKDATEAEIKKAYRKLARENHPDANKGNVKAEERFKEISEANDILGDPKKRKEYDEARALFGNGGFRPGPGAGGGGTFNFDLGDLFGGGAQGGGGQGGAGGFGGGLGDVFGGLFNRTGGGPGTGTRTQPRRGQDIESEVTLSFTEAIEGATVPLRMSSQAPCKACSGTGDKNGTPRVCPTCVGTGQVARGSGGGFSLTDPCPDCKGRGLIAEDPCEVCKGSGRAKSSRTMQVRIPAGVSDGQRIRLRGKGTPGERGGPAGDLYVVVHVKEHPVFGRRGDNLTVTVPVTYAEAALGGEVRVPTLGGPSVTLKLPAGTPNGRTMRARGKGAVRKDGTRGDLLVTVEVSVPKDLTGKARDALQAYREATADEDPRAELFQAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKE7</accession>
    <name>Q7AKE7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6312</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42057">
        <property type="entry name" value="T42057"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630409.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972614.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKE7"/>
    <dbReference type="STRING" id="100226.SCO6312"/>
    <dbReference type="GeneID" id="1101753"/>
    <dbReference type="KEGG" id="sco:SCO6312"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6426"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_8_0_11"/>
    <dbReference type="InParanoid" id="Q7AKE7"/>
    <dbReference type="PhylomeDB" id="Q7AKE7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC37533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23857" checksum="811989AC857A892E" modified="2012-05-16" version="1">MARQLRAERTRATIVRAAADLFDRHGYESTSLSEIVAHAGVTKGALYFHFAAKEDLAHAIMEMQSRTFRRLANDLDGRGYSSLEALMRLTFGMARVYEEGPVLRAGTRLATAGVPVRPPLPHPFTDWREIATSRLLDAVRQSDVHQDIDVDSVAHTLVSSVVGTCVVGGTLEPAGRQPRRLAEMWYILIRGMVPVTRRARYVTLAARLEQETGTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-10-16" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKG9</accession>
    <accession>O87834</accession>
    <name>SIGR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>ECF RNA polymerase sigma factor SigR</fullName>
            <shortName>ECF sigma factor SigR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Alternative RNA polymerase sigma factor SigR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>RNA polymerase sigma-R factor</fullName>
            <shortName>Sigma-R factor</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">sigR</name>
        <name type="ordered locus">SCO5216</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="EMBO J." volume="17" first="5776" last="5782">
            <title>sigmaR, an RNA polymerase sigma factor that modulates expression of the thioredoxin system in response to oxidative stress in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Paget M.S."/>
                <person name="Kang J.G."/>
                <person name="Roe J.H."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="9755177"/>
            <dbReference type="DOI" id="10.1093/emboj/17.19.5776"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 5-24</scope>
        <scope>FUNCTION AS A SIGMA FACTOR</scope>
        <scope>INDUCTION</scope>
        <scope>AUTOREGULATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="EMBO J." volume="18" first="4292" last="4298">
            <title>RsrA, an anti-sigma factor regulated by redox change.</title>
            <authorList>
                <person name="Kang J.G."/>
                <person name="Paget M.S.B."/>
                <person name="Seok Y.J."/>
                <person name="Hahn M.Y."/>
                <person name="Bae J.B."/>
                <person name="Hahn J.S."/>
            </authorList>
            <dbReference type="PubMed" id="10428967"/>
            <dbReference type="DOI" id="10.1093/emboj/18.15.4292"/>
        </citation>
        <scope>FUNCTION AS A SIGMA-FACTOR</scope>
        <scope>INTERACTION WITH RSRA</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="1007" last="1020">
            <title>Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigmaR regulon.</title>
            <authorList>
                <person name="Paget M.S.B."/>
                <person name="Molle V."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="11737643"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02675.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>REGULON</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Mol. Biol." volume="333" first="461" last="472">
            <title>The role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Li W."/>
                <person name="Bottrill A.R."/>
                <person name="Bibb M.J."/>
                <person name="Buttner M.J."/>
                <person name="Paget M.S."/>
                <person name="Kleanthous C."/>
            </authorList>
            <dbReference type="PubMed" id="14529630"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2003.08.038"/>
        </citation>
        <scope>FUNCTION AS A SIGMA FACTOR</scope>
        <scope>INTERACTION WITH RSRA</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="Mol. Microbiol." volume="68" first="861" last="870">
            <title>Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and sigma(R) in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Park J.H."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="18430082"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06191.x"/>
        </citation>
        <scope>REGULON</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="815" last="825">
            <title>Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigmaR in actinomycetes.</title>
            <authorList>
                <person name="Kim M.S."/>
                <person name="Hahn M.Y."/>
                <person name="Cho Y."/>
                <person name="Cho S.N."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="19682253"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06824.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>ALTERNATIVE INITIATION (SIGR PRIME)</scope>
        <scope>PROBABLE CLEAVAGE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2012" name="Mol. Microbiol." volume="85" first="326" last="344">
            <title>Conservation of thiol-oxidative stress responses regulated by SigR orthologues in actinomycetes.</title>
            <authorList>
                <person name="Kim M.S."/>
                <person name="Dufour Y.S."/>
                <person name="Yoo J.S."/>
                <person name="Cho Y.B."/>
                <person name="Park J.H."/>
                <person name="Nam G.B."/>
                <person name="Kim H.M."/>
                <person name="Lee K.L."/>
                <person name="Donohue T.J."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="22651816"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2012.08115.x"/>
        </citation>
        <scope>REGULON</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2002" name="J. Mol. Biol." volume="323" first="225" last="236">
            <title>Identification and structure of the anti-sigma factor-binding domain of the disulphide-stress regulated sigma factor sigma(R) from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Li W."/>
                <person name="Stevenson C.E."/>
                <person name="Burton N."/>
                <person name="Jakimowicz P."/>
                <person name="Paget M.S."/>
                <person name="Buttner M.J."/>
                <person name="Lawson D.M."/>
                <person name="Kleanthous C."/>
            </authorList>
            <dbReference type="PubMed" id="12381317"/>
            <dbReference type="DOI" id="10.1016/S0022-2836(02)00948-8"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 23-109</scope>
        <scope>INTERACTION WITH RSRA</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5 7 10">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor (RsrA) until released. Responds to thiol-oxidative stress, involved in regulation of about 30 genes and operons, including the thioredoxin system (trxB-trxA, trxC), ribosomal protein L31, RNA polymerase-binding protein RbpA and mycothiol (MSH) biosynthetic (mshA) and recycling genes (mca). In conjunction with its cognate anti-sigma factor RsrA may sense the intracellular level of reduced MSH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 6 7">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription. Interacts with cognate anti-sigma factor RsrA under reducing but not oxiding conditions, which prevents it binding to RNA polymerase. Treatment with the thiol-oxidzing agent diamide inhibits the interaction.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>Q7AKG9-1</id>
            <name>SigR</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>Q7AKG9-2</id>
            <name>SigR prime</name>
            <sequence type="described" ref="VSP_053231"/>
        </isoform>
    </comment>
    <comment type="induction">
        <text evidence="8 9 10">Expressed from 2 promoters, 1 of which (sigRp2) positively regulates its own expression. The same promoter is transiently induced (about 70-fold) by the thiol-oxiding agent diamide. Also induced when mycothiol is oxidized or conjugated.</text>
    </comment>
    <comment type="domain">
        <text evidence="1 11">The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain-2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity). Interactions between sigma-70 factor domain-2 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA.</text>
    </comment>
    <comment type="PTM">
        <text>SigR is present in multiple forms of different pI, suggesting other unknown post-translational modifications.</text>
    </comment>
    <comment type="PTM">
        <text>SigR prime is probably partially degraded by ClpP1-ClpP2.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="8 10">Increased sensitivity to redox-cycling compounds menadione and plumbagin, and to diamide. Loss of expression of mycothiol biosynthetic and recycling genes.</text>
    </comment>
    <comment type="miscellaneous">
        <molecule>Isoform SigR</molecule>
        <text>Constitutively expressed major isoform, not induced by diamide (at protein level), contributes about half of the diamide-induced expression of the regulon.</text>
    </comment>
    <comment type="miscellaneous">
        <molecule>Isoform SigR prime</molecule>
        <text evidence="11">Present in low amounts in unstressed cells, strongly but transiently produced upon diamide induction. Functions as a sigma factor, contributes about half of the diamide-induced expression of the regulon. Unstable, half-life of about 10 minutes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AJ010320">
        <property type="protein sequence ID" value="CAA09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42015">
        <property type="entry name" value="T42015"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629363.1">
        <molecule id="Q7AKG9-1"/>
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973756.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="PDB" id="1H3L">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.38 A"/>
        <property type="chains" value="A/B=23-109"/>
    </dbReference>
    <dbReference type="PDB" id="5FGM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A=143-207"/>
    </dbReference>
    <dbReference type="PDBsum" id="1H3L"/>
    <dbReference type="PDBsum" id="5FGM"/>
    <dbReference type="AlphaFoldDB" id="Q7AKG9"/>
    <dbReference type="SMR" id="Q7AKG9"/>
    <dbReference type="STRING" id="100226.SCO5216"/>
    <dbReference type="GeneID" id="1100657"/>
    <dbReference type="KEGG" id="sco:SCO5216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5300"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_1_1_11"/>
    <dbReference type="InParanoid" id="Q7AKG9"/>
    <dbReference type="OMA" id="NAKAWLF"/>
    <dbReference type="PhylomeDB" id="Q7AKG9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0024">Alternative initiation</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0731">Sigma factor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000423649" description="ECF RNA polymerase sigma factor SigR">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4">
        <location>
            <begin position="148"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Polymerase core binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="splice variant" id="VSP_053231" description="In isoform SigR prime." evidence="11">
        <original>M</original>
        <variation>MGSAFCPSRSSRADLDWTVLHAAKTAPIRAAGGPDRRLSSDSSETGLGFTTTSEEM</variation>
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="12">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="13">
        <location>
            <begin position="148"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="helix" evidence="13">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="helix" evidence="13">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="helix" evidence="13">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="10428967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="11737643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="12381317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="14529630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="18430082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="19682253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="9755177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="1H3L"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5FGM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25218" checksum="AE89C2EF0ED4F366" modified="2012-05-16" version="1">MGPVTGTDAGTEHGQAEQPEGRGTGAESTAERSARFERDALEFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKQALQAIPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGESNEAKGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKP5</accession>
    <name>Q7AKP5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626458.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028197.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2207"/>
    <dbReference type="GeneID" id="1097640"/>
    <dbReference type="KEGG" id="sco:SCO2207"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2245"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086952_0_0_11"/>
    <dbReference type="OMA" id="GEQVCNG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176023" evidence="2">
        <location>
            <begin position="37"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="231" mass="23379" checksum="3AB465A7E7F08892" modified="2012-05-16" version="1">MSRRRTLGTQKKIVLLVGAAAVAGGGAFLAATASNAAQTTPEARTKAAQDSGVCQGLATALGNNQRFIEGQRADPDAQSQARIENREAVVAEIERKQAASGCAVGESAQDPQAAQPPQSGQDTGGQAGDQAGDQAGNQTGDRAGGAAQAGEQVCAGSTVTLSGEGGAPAASSDRFPVGTKLRVTNLDNDKSTTVEVNSVSGSCALLNNAAFEQVREEGKFLIRRALIEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJY5</accession>
    <name>Q8CJY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2770</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAD55203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733583.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976030.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2770"/>
    <dbReference type="GeneID" id="1098204"/>
    <dbReference type="KEGG" id="sco:SCO2770"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2827"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJY5"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="PhylomeDB" id="Q8CJY5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, using agmatinase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="34302" checksum="10972C568ED63A9B" modified="2003-03-01" version="1">MSSNETPRGPVDSSRIPRYAGPATFARLPRLDEVGAADVAVVGVPFDSGVSYRPGARFGGNAIREASRLLRPYNPAQDASPFALAQVADGGDIAVNPFNIHEAVETIEAAADDLLGTGARLMTLGGDHTIALPLLRSVAKKHGPVALLHFDAHLDTWDTYFGAEYTHGTPFRRAVEEGVLDTSALSHVGTRGPLYGKKDLTDDEKMGFGIVTSADVYRRGADEIADQLRQRIGDRPLYISIDIDCLDPAHAPGTGTPEAGGMTSRELLEILRGLASCNLVSADVVEVAPAYDHAEITSVAASHTAYELTTIMSRQIAEARTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK16</accession>
    <name>Q8CK16_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1816</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAD55180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36780">
        <property type="entry name" value="T36780"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733547.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027991.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1816"/>
    <dbReference type="GeneID" id="1097250"/>
    <dbReference type="KEGG" id="sco:SCO1816"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1837"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_11"/>
    <dbReference type="InParanoid" id="Q8CK16"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="PhylomeDB" id="Q8CK16"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="253"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="54410" checksum="0AFE3B3C1DDD43D8" modified="2003-03-01" version="1">MPHSIDQAFTALPLRALADAALARARALGAEHADFRLERVRNASWRLRDARPAGSSDTTDLGYAVRVVHGGTWGFASGVDLTLDAAAKVASQAVAMAKLSAQVIKAAGSDERVELAAEPVHADKSWISAYEIDPFSVPDADKAALLADWSARLLAADGVDHVDASLLTVHENKFYADTAGTVTTQQRVRLHPVLTAVSVDDSSGEFDSMRTLAPPAGRGWEYLTGTGWDWDSELAEIPELLAEKMRAPSVEAGLYDLVVDPSNLWLTIHESIGHATELDRALGYEAAYAGTSFATFDQLGKLRYGSELMNVTGDRTAEHGLATVGYDDEGVEGQSWDLVKDGTLVGYQLDRRIARLTGFERSNGCAYADSPAHVPVQRMANVSLLPDPGGLSTEDLIGGVDRGIYVVGDRSWSIDMQRYNFQFTGQRFFRIENGRLAGQLRDVAYQATTTDFWGSMAAVGGPQTYVLGGAFNCGKAQPGQVAAVSHGCPSALFKGVNILNTTQEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IU1</accession>
    <name>Q93IU1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BldKC, putative ABC transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5114</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629264.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973863.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5114"/>
    <dbReference type="TCDB" id="3.A.1.5.36">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100555"/>
    <dbReference type="KEGG" id="sco:SCO5114"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5197"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IU1"/>
    <dbReference type="OMA" id="IFTAQYT"/>
    <dbReference type="PhylomeDB" id="Q93IU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC44321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="35607" checksum="710369845245E634" modified="2001-12-01" version="1">MLQFLIRRSFGAVLILVLISAFTFFMFFAIPQDPAMLACGKNCTPDALEIIHKNLGLDQPVTVQYWHFLAGIFTGRDFAVGHCDAPCFGVSFANNQNVWDTILDRFPLTVSLTVGSLIVFLIVGLGAGLLAAKNRGTWIDKVFSSGSLVVSSLQIYFLGPLVLLALVYSTGWLQKPKYVPISEDAAGWFAGLLIPWIVMATIFTANYTRMSRSSMIEQLQEEHVRAARAKGMSSNYTFFRYAWRGSLVPIVTILGIDLSALMGGGMVTEMTFGLAGIGRLALESVINKDLPMLMGVMLVSAALIIVFNLIVDAMYAVIDPRVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IW2</accession>
    <name>Q93IW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625594.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027711.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1308"/>
    <dbReference type="GeneID" id="1096731"/>
    <dbReference type="KEGG" id="sco:SCO1308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1311"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057691_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IW2"/>
    <dbReference type="OMA" id="VWDYQEF"/>
    <dbReference type="PhylomeDB" id="Q93IW2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="17"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="43968" checksum="BBA0E9C1598A81A3" modified="2001-12-01" version="1">MTAPSRHPDSAAPRGISVVVVGAGPAGLTVGSILRAAGVGCLVLETATREVVEHRPRAGVIEEWAVRGLARRGLARTLLERAQAHTECEFRFAGERYRFGYTGLTGRHHFVYPQQFLVTDLVREYADVRGGEIRFGVRDVRLHGTGSARPAVSYVCPDSGERRVVEADFVAGCDGARGVTRASLPAGRVRLARHDYGVGWLALLAEAPPSSDCVVFGMHPRGFAGHMARSPEVTRYYLQCPPGDSPENWPHERVWAELRERLGAAGAPPLAEGRLIEKRVLDMHSYVVEPMAFGRLFLAGDAAHLTAPIAAKGLNLALHDAFLLGDGLVAALTKGDDSALAGYSDACLARVWDYQEFSQWLAEMYHGTASGDPYRAGAALARLRRLFSSPAAAAEFAERYLGVRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JC6</accession>
    <name>Q93JC6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phenylacetic acid degradation protein PaaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7470</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631517.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7470"/>
    <dbReference type="GeneID" id="1102908"/>
    <dbReference type="KEGG" id="sco:SCO7470"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7581"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_11_0_11"/>
    <dbReference type="InParanoid" id="Q93JC6"/>
    <dbReference type="OMA" id="FACNSHN"/>
    <dbReference type="PhylomeDB" id="Q93JC6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016289">
        <property type="term" value="F:CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011973">
        <property type="entry name" value="PaaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02286">
        <property type="entry name" value="PaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="18209" checksum="A5B4C667E79FCB83" modified="2001-12-01" version="1">MVDTVSQATEQTPTEAMFSADEASRGLGIELVEHGEGTALVRMTVTPAMVNGHRIAHGGFLFLLADTAFACACNSHGPVTVAAGADIVFVAPAREGDVLVARAEERVRYGRSGIYDVSVRRGDEVVAEFRGRSRSVRDDGRDRSARDDAGSRDARQDTARETPGTTKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ0</accession>
    <name>Q93JJ0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ordered locus">SCO1971</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626234.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976848.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1971"/>
    <dbReference type="GeneID" id="1097405"/>
    <dbReference type="KEGG" id="sco:SCO1971"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1997"/>
    <dbReference type="eggNOG" id="COG2313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_0_1_11"/>
    <dbReference type="OMA" id="RKLGHRD"/>
    <dbReference type="PhylomeDB" id="Q93JJ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="31483" checksum="4DC93C1BD2F698C8" modified="2001-12-01" version="1">MLVLSEEVREAMDARRPVVALESTIIAHGLPRPRNLLVARELEEAVRQEGAVPATIAVLDGRPHVGLDKEQLERVAGEDGIRKLGHRDLPLAVASGASGATTVSATALLADLAGVRVFATGGLGGVHREWTVTQDESADLGLLARTRITVVCAGVKSILDVPATLQRLETLGVAVAGYGTDRFPGFYLSDSGHPVDWTLDDPGQVAAVMRAQDALDGPRSALVVANPVPEQEQLDPGLHARVLADALHACEAEGVTGQAVTPFLLERLVRLTDGASLSANLAAVRGNVRLAARIAAAWTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RS8</accession>
    <name>Q93RS8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCO6316 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6316</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630411.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1101757"/>
    <dbReference type="KEGG" id="sco:SCO6316"/>
    <dbReference type="HOGENOM" id="CLU_3361801_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="36" mass="3906" checksum="1F6379CD0258DA03" modified="2001-12-01" version="1" fragment="single">VVQFGNRHHAVTAPSLTSDEGADIMTGYGRHRPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RX6</accession>
    <name>Q93RX6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6296</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630394.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030803.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6296"/>
    <dbReference type="GeneID" id="1101737"/>
    <dbReference type="KEGG" id="sco:SCO6296"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_6_0_11"/>
    <dbReference type="InParanoid" id="Q93RX6"/>
    <dbReference type="OMA" id="DWVDYNG"/>
    <dbReference type="PhylomeDB" id="Q93RX6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC37898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17464" checksum="27A094AB2984DA85" modified="2001-12-01" version="1">MTGLPLLHSTVRPEWIDYNGHLSEAFYVLVFGHATDALMTGTGLDSGYRESTRCSLYTVESHIRFLRDVSEGAHLAVRTRVLGAAARKARFQHEMYVVPGPEAEPAPDAAAVATTELLAVHVDQQAGRATEFPESVRRRFTELTEPPPHWAGRSIPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q69</accession>
    <name>Q99Q69_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.315</name>
        <name evidence="1" type="ordered locus">SCP1.39c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639615.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639923.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039341.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095118"/>
    <dbReference type="GeneID" id="1095397"/>
    <dbReference type="KEGG" id="sco:SCP1.315"/>
    <dbReference type="KEGG" id="sco:SCP1.39c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7985"/>
    <dbReference type="HOGENOM" id="CLU_127704_0_0_11"/>
    <dbReference type="OMA" id="KGWPPLI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="15369" checksum="A6F8921B73DBD973" modified="2001-06-01" version="1">MPRASRRKGDAARRHADTIRFVLFEARPAGLAMHQLITASGLSDSQVRSGLAALRDEAAAKGWPPLIWTRTDGYQLDAERAALEAYERAVVREKLTQFRRFITGTVTPHAAAHPNDKWVKHIVAQLNSIESTLDLIASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACY0</accession>
    <name>Q9ACY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.171</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639745.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039470.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095249"/>
    <dbReference type="KEGG" id="sco:SCP1.171"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8117"/>
    <dbReference type="HOGENOM" id="CLU_079642_0_0_11"/>
    <dbReference type="OMA" id="PPWDGLR"/>
    <dbReference type="PhylomeDB" id="Q9ACY0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323098" evidence="2">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="31366" checksum="877F98E625288527" modified="2001-06-01" version="1">MIALNVIAPAAAAGVLVGLGVRAAWPAKPDLTSALDRLDASKVPTALPTDALAPTGSLPERVGNRLLADFGDRIALPLRDLNLLRISPAEHLGKRALFALYGLVIPLLLQAMLALAGAPFPYVVPAGLSLGLAALFWLWPGREVAKEAAEARLIVRHAAASYLERVALARVANSGAAQALTDTARVGENFIFNRMRQVFHQADLAGVTPWDALKQLGEELDIPELTRPADTLALAGDGAAVYTTLQAQARQLRIALLSDQKAKANEASAAMILPVTFGVILMITFVMIPLTITILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD83</accession>
    <name>Q9AD83_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4914</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629067.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029945.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4914"/>
    <dbReference type="GeneID" id="1100355"/>
    <dbReference type="KEGG" id="sco:SCO4914"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4993"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_3_0_11"/>
    <dbReference type="InParanoid" id="Q9AD83"/>
    <dbReference type="OMA" id="RYSGPDY"/>
    <dbReference type="PhylomeDB" id="Q9AD83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD30905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="331" mass="34526" checksum="209D0F5C8DE457B5" modified="2001-06-01" version="1">MPTTAPAANGPAQGPANGPAHGFADVTASDSTLRRFLHGLPGVDTVGLEARAASLGTRSIKTTAKAYALDLAISMVDLTTLEGADTPGKVRALGAKSVRPDPTDRTAPATAAVCVYPDMVPTAREAVAGSGVKVASVATAFPAGRASLAVKLADVREAVAAGADEVDMVIDRGAFLAGNYMKVYDEIAAVREACGTSARLKVIFETGELSTYDNIRRASWLGMLAGADFIKTSTGKVAVNATPANTLLMLEAVRDFRAQTGVQVGVKPAGGIRTAKDAIKFLVLVNETAGEDWLDNHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK10</accession>
    <name>Q9AK10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631756.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031853.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7718"/>
    <dbReference type="GeneID" id="1103156"/>
    <dbReference type="KEGG" id="sco:SCO7718"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7840"/>
    <dbReference type="eggNOG" id="ENOG5031E5C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1174896_0_0_11"/>
    <dbReference type="OMA" id="WYDHSPT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="27098" checksum="145C44FEA02B368C" modified="2001-06-01" version="1">MTTQHAGAGRSGPQSTSVTSESPFKPPLVKAVFRDVTPMHVSRSAAWAAASVTRTVLTEIVQGARAAAAAEDRRKLIPGDLLSAIDRNVELEVGTTWYDHSPTFRGLTGVVYDAEGVVVPSRGRGGSRRPSAVVGAHRFEAGVRKLLRSRGTAAVPAMVRDLDGIASVFLTDLARDAAMVVREGGVKRFGSVVQAMPDEPAPAPFPKDFLGALSARSGDGRTIGRDDILAATTMRLFGGLRQRALTEAREAAQNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK47</accession>
    <name>Q9AK47_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4879</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629032.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029923.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4879"/>
    <dbReference type="GeneID" id="1100320"/>
    <dbReference type="KEGG" id="sco:SCO4879"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4959"/>
    <dbReference type="eggNOG" id="ENOG502Z966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053691_0_0_11"/>
    <dbReference type="OMA" id="PGEHTTH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="443" mass="47951" checksum="9D29F9D446662FCD" modified="2001-06-01" version="1">MPASATKALRVAVLADSDTRWKWGALTATRVCPGDTEIHLDGYLLRGRATPTARQLREVGVDADSLREVTAVEFLRAMEGAGEGDGEPYDVLVLALVGGGVQAMLHGLGRVWRDRAERPVVVTGYVGVVYEKLADGLLLRHGADLVLANSRQDAERFRAVYEGVGADTAAVTEVALPFLGGAAHGGEHDPYTVVFAAQPSVPDSRKDRTYLLERLIRHARLHPEREVLLKLRSRPGEHTTHIEELPYQKLVQRADPPPNFRLVYGHMGEVLDRTDLLVTVSSTAALESLHRRIPTVVLTDLGVREALGNHHFVGSGCLASWDQLDAGHRPAPDAEWVARQGVAADGGYETAFDEARKRIAALLSRPAGLPPLAPYYTPVTAPGYLPGILARHHLAPDGTPLPGAPAADRAPGPVRQVVRRAARGAYRHGVQRVAPVIRRMGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK78</accession>
    <name>Q9AK78_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974923.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4039"/>
    <dbReference type="GeneID" id="1099475"/>
    <dbReference type="KEGG" id="sco:SCO4039"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4102"/>
    <dbReference type="eggNOG" id="ENOG50331J9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125819_0_0_11"/>
    <dbReference type="OMA" id="IEQEDAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="182" mass="19164" checksum="AEA0CFCCDC5C084C" modified="2001-06-01" version="1">MYFAALLARTEDGWEASDTELDDVETLSDLADLAREASPDEDTVLVLIEQEDAWFGVVRVDGEEDPRIYVSDAAAAARSSYGEILLTDELLGREPDDDGDDLDALDLDGTEDGESDDEEDEDGGGSDAAAGSGEAVPHGPVGDAEVLDDLGVSEKELRSMSGDAVGEIAEALGALDVLETVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-26" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF7</accession>
    <name>MSRA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="1">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="1">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="1">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrA</name>
        <name type="ordered locus">SCO4956</name>
        <name type="ORF">2SCK31.16</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629108.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974020.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9EWF7"/>
    <dbReference type="SMR" id="Q9EWF7"/>
    <dbReference type="STRING" id="100226.SCO4956"/>
    <dbReference type="GeneID" id="1100397"/>
    <dbReference type="KEGG" id="sco:SCO4956"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5036"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_11"/>
    <dbReference type="InParanoid" id="Q9EWF7"/>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="PhylomeDB" id="Q9EWF7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036456">
        <property type="term" value="F:L-methionine-(S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138595" description="Peptide methionine sulfoxide reductase MsrA">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <sequence length="172" mass="19308" checksum="8A0C87B5237F6607" modified="2001-03-01" version="1">MAAQTQRAVLAGGCFWGMEELIRRLPGVTATRVGYTGGDVPNATYRNHGTHAEAIEILFDPEATDYRALLEFFFQIHDPSTKNRQGNDIGLSYRSAIYYVDDEQKRIAEDTIADVDASGLWPGKVVTEVEPVGPFWEAEPEHQDYLQRYPDGYTCHFPRPGWRLPARSGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWI2</accession>
    <name>Q9EWI2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7602</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631644.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971542.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1103040"/>
    <dbReference type="KEGG" id="sco:SCO7602"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7718"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_23_1_11"/>
    <dbReference type="InParanoid" id="Q9EWI2"/>
    <dbReference type="OMA" id="IWRRQLM"/>
    <dbReference type="PhylomeDB" id="Q9EWI2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="21640" checksum="2C2766C1D63061F6" modified="2001-03-01" version="1">MTSTAARPGRVAKLPPRERILDAAEELFQGEGIRRVGVQAIAERAETTKMAIYRHFETKDALVAEWLRILAAEYQAAFDRVEAEHPGRPREQILGLARFIADGLPGLSHRGCPFINSLAELPDRSHPARRVIEEHKARQTRRLVGMCAEAGMPDPEQVAAQITFVLEGAQVSTQNASIDRAGERLMRIVEAIVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWV7</accession>
    <name>Q9EWV7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4924</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974049.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4924"/>
    <dbReference type="GeneID" id="1100365"/>
    <dbReference type="KEGG" id="sco:SCO4924"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5003"/>
    <dbReference type="eggNOG" id="ENOG502ZP0H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210491_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="42" mass="4757" checksum="80998DDEBBAC91FB" modified="2001-03-01" version="1">MLWSDPENEPPKELRDTQDMLRRLSVFLALAMVLAMVVLGLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-28" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWW8</accession>
    <name>DER_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">SCO1758</name>
        <name type="ORF">2SCI34.11c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAC12931" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC12931.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626030.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9EWW8"/>
    <dbReference type="SMR" id="Q9EWW8"/>
    <dbReference type="STRING" id="100226.SCO1758"/>
    <dbReference type="GeneID" id="1097189"/>
    <dbReference type="KEGG" id="sco:SCO1758"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1776"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_11"/>
    <dbReference type="InParanoid" id="Q9EWW8"/>
    <dbReference type="PhylomeDB" id="Q9EWW8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000179053" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="202"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="376"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="465" mass="50344" checksum="9E053E7C00C859F8" modified="2002-11-28" version="2">MELAAEEGFDIEDVEGAIEEAGHGPLPVLAVVGRPNVGKSTLVNRIIGRREAVVEDKPGVTRDRVTYEAEWAGRRFKVVDTGGWEQDVLGIDASVAAQAEYAIEAADAVVFVVDAKVGATDTDEAVVRLLRKAGKPVVLCANKVDGPSGEADASYLWSLGLGEPQPVSALHGRGTGDMLDRVLEALPEAPAQTFGTAVGGPRRIALIGRPNVGKSSLLNKVAGEDRVVVNELAGTTRDPVDELIELGGVTWKFVDTAGIRKRVHLQQGADYYASLRTAAAVEKAEVAVILVDASESISVQDQRIVTMAVEAGRAIVVAYNKWDTLDEERRYYLEREIETELGQVAWAPRVNVSAQTGRHMEKLVPAIETALAGWETRVPTGRLNAFLGELAAAHPHPVRGGKQPRILFGTQAGTKPPRFVLFASGFIEAGYRRFIERRLREEFGFEGTPIHISVRVREKRGAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX40</accession>
    <name>Q9EX40_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe uptake system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0998</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625294.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027507.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0998"/>
    <dbReference type="GeneID" id="1096421"/>
    <dbReference type="KEGG" id="sco:SCO0998"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.996"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="InParanoid" id="Q9EX40"/>
    <dbReference type="OMA" id="KALCQEI"/>
    <dbReference type="PhylomeDB" id="Q9EX40"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC14366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="28866" checksum="E5E4F1CB0BC29B9D" modified="2001-03-01" version="1">MTATELVIDGVTLTAGAHRLVEDVSLTARPGEVIGLVGPNGSGKSSLLRAVYRILRPTTGQVSVDGTDAWSLPVRQLARTVAAVVQESGAEFELTVREVVAMGRTPHKRLLDGDTAEDAGLIRSALTAVDATDLAHRPFDQLSGGERQRVLIARALAQQPSLLVLDEPTNHLDIRHQLDVLGALRRLPATVLVALHDLNLAAYYCDRLYVLCDGKVTAAGPPADILTSQLLSEVYGVTSEVTIHPRTGAPQVTFLPGASRLDAPVEANPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2P3</accession>
    <name>Q9F2P3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3107</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627325.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028771.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1098541"/>
    <dbReference type="KEGG" id="sco:SCO3107"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3170"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_0_1_11"/>
    <dbReference type="InParanoid" id="Q9F2P3"/>
    <dbReference type="OMA" id="PNCKEAI"/>
    <dbReference type="PhylomeDB" id="Q9F2P3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176660" evidence="2">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="3">
        <location>
            <begin position="119"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC09548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27422" checksum="C84C1AAEB9BAFD0F" modified="2001-03-01" version="1">MTRHSRIRTGWAAGAAALALALVTGCEGLEADGDAPASGGGAQAPAAGHAVSPLDNPDGTEPGLAPVTGDSPQAAARKLIDGLPTKGRGPKTGYDRDEFGYAWMDTADGVPLARNGCDTRNDLLKRDGQEVRFKSGSDCVVIAMTLDDPYTGTSIEWRKQKASEVQIDHVVPLSYSWQMGSSRWPENKREQLANDPLNLLPVEGRANSAKRDSGPASWLPPDKAVRCAYAVRFAQVAAKYELAVTEADRAMMAKQCQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2S0</accession>
    <name>GSA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="1">GSA</shortName>
            <ecNumber evidence="1">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="1">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemL</name>
        <name type="ordered locus">SCO4469</name>
        <name type="ORF">SCD65.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628635.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029675.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F2S0"/>
    <dbReference type="SMR" id="Q9F2S0"/>
    <dbReference type="STRING" id="100226.SCO4469"/>
    <dbReference type="GeneID" id="1099909"/>
    <dbReference type="KEGG" id="sco:SCO4469"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4538"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_11"/>
    <dbReference type="InParanoid" id="Q9F2S0"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="PhylomeDB" id="Q9F2S0"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000120459" description="Glutamate-1-semialdehyde 2,1-aminomutase">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <sequence length="438" mass="45341" checksum="2B7A4909C4BD1197" modified="2001-03-01" version="1">MSELAYPYEAPASQALFDRAAAVTPGGVNSPVRAFRAVGGTPRFMVSGTGPYLTDADGREYVDLVCSWGPMILGHAHPEVIAAVQEAVARGTSFGTPAEGEVALAEAMVERVAPLEEVRLVSSGTEATMSAIRLARGFTRRTKVIKFAGCYHGHVDSLLAAAGSGVATFALPDTPGVTGAQASDTIVLPYNDLDAVHAAFAAHPGEIACVITEASPGNMGVVPPLPGFNQGLKDACAANGALFVSDEVMTGFRTSLAGWFGVEGVVPDLMTFGKVMGGGFPAAAFGGRADVMAHLAPAGPVYQAGTLSGNPVATAAGLAQLRLLDDAAYDTVDAVSAQIQALVTEALTKEGVAHTLQNASNMFSVFFTDRPVVNYEDAKAQESFRFTAFFHSLLANGVYLPPSSFESWFVSTAHDERAVQRIADALPAAARAAAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F373</accession>
    <name>Q9F373_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4415</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628583.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029638.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4415"/>
    <dbReference type="GeneID" id="1099855"/>
    <dbReference type="KEGG" id="sco:SCO4415"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4485"/>
    <dbReference type="eggNOG" id="ENOG5031WTZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949733_0_0_11"/>
    <dbReference type="OMA" id="ELWILER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="30985" checksum="97FEBECFCBF9604F" modified="2001-03-01" version="1">MGWGTEPEAAEGRPLPWSNDEWNVAAALCATQLPLMWLAWWFFVGAGQDDHGRGGGAFGVLCLPLVLPLLGVVHSSAQIMPAATLARLLPRRSGPEWARHVVASVLVGAGWAVLGHLVWGWPPRDTVPWFAGAGILPVLFLAPLRRRAWGGWSVWLRSAGACFVLSVAGGLAVAALADEYEPPALSDGQLAGEWRGDHGAVLRLAPGGRAGLTRVPSRPDFGTYRDYTRCSGTGTWSRNLSGDREGVVVRLDGDCGEETSWTIGGSERSPELFALFGDPDAGDLLFLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3D9</accession>
    <name>Q9F3D9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7618</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631659.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031782.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7618"/>
    <dbReference type="GeneID" id="1103056"/>
    <dbReference type="KEGG" id="sco:SCO7618"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7736"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_5_2_11"/>
    <dbReference type="InParanoid" id="Q9F3D9"/>
    <dbReference type="OMA" id="APRVDLW"/>
    <dbReference type="PhylomeDB" id="Q9F3D9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC16720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="28223" checksum="B27735B43B49195C" modified="2001-03-01" version="1">MPDPRGGAQGGGVSGQEGPTLISSVQRAFRLMEAVGAHESGVPAKQLARETGLALGTTYHLLRTMVHDGYVRKLEDGTFVLGERLGALHAGSRDQTALSRVRPTLTELRDDLSAAAYLTLYEEGEIRVAEIVDGPKAPRVDLWVGFEDAGHATALGKSVLRELDAEARADYLSRHALNDLTPRTITYRAQLLRSLDAAPRGPAVTDLEEYRLGTACVAVPVRRGDTIGSLGISVDINRTACLDDAVTTLLATAERVSRGLSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3J3</accession>
    <name>Q9F3J3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5272</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629418.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973697.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5272"/>
    <dbReference type="GeneID" id="1100713"/>
    <dbReference type="KEGG" id="sco:SCO5272"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5357"/>
    <dbReference type="eggNOG" id="ENOG5030HH7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204030_0_0_11"/>
    <dbReference type="OMA" id="EPSEMLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026334">
        <property type="entry name" value="FxSxx-COOH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04268">
        <property type="entry name" value="FxSxx-COOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6920" checksum="DFBECA0251AB04F0" modified="2001-03-01" version="1">MDIRDEAGAEQATAGAGEPLPDLLELDLAQLGTVEHPVLREVLGELRARAAEPSEMLWGFDNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBP2</accession>
    <name>Q9FBP2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5035</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629187.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973942.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5035"/>
    <dbReference type="GeneID" id="1100476"/>
    <dbReference type="KEGG" id="sco:SCO5035"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5113"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9FBP2"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="PhylomeDB" id="Q9FBP2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC05880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="24531" checksum="E391C68ACABC1624" modified="2001-03-01" version="1">MTPPAGSLLSADQLRKAYGPTLALDGAEFSIHPGEVVAVMGPSGSGKSTLLHCLAGIVPPDSGTITYNGRELSAMSDAQRSALRRSDFGFVFQFGQLVPELTCVENVALPLRLNGTSRKEAERAALSWMERLEVDDLRKKRPGEVSGGQGQRVAVARSLVTNPRVLFADEPTGALDSLNGERVMELLTDAARSTNAAVVLVTHEARVAAYSDREIVVRDGKSRDMERAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBS3</accession>
    <name>Q9FBS3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7169</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631228.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031476.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1102607"/>
    <dbReference type="KEGG" id="sco:SCO7169"/>
    <dbReference type="HOGENOM" id="CLU_1795334_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="14319" checksum="3B314693DE7AA596" modified="2001-03-01" version="1">MTPVAAAKAGRTAVTRKVEAAHDLEPRSGRPSATDGGSGTARGARTAGSGTNAGSGTNAGGAGTVLDRRADQRAMDRPREAEGPPVGSTGQAGAGRETADSAGRLRSLRADGPTTGSRPARDRVGPGRAGPEGAPRTRSAQPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBU5</accession>
    <name>Q9FBU5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7146</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631205.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031460.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7146"/>
    <dbReference type="GeneID" id="1102584"/>
    <dbReference type="KEGG" id="sco:SCO7146"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7248"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_4_2_11"/>
    <dbReference type="OMA" id="HEVACGE"/>
    <dbReference type="PhylomeDB" id="Q9FBU5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="116" mass="12528" checksum="25465DC24E7AC7A6" modified="2001-03-01" version="1">MPDHHASPAVSEISLPRLLGVLSDPTRLGIVRILSDGAERGWGQFSAPVAKSTLSHHLKMLREAGVTQTRQEGTRCFVKLRGDALETRFPGLLPALLSAAGTDHVGEHVTERDEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBX3</accession>
    <name>Q9FBX3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7811</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031932.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7811"/>
    <dbReference type="GeneID" id="1103249"/>
    <dbReference type="KEGG" id="sco:SCO7811"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7922"/>
    <dbReference type="eggNOG" id="COG3371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980250_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC03629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="13301" checksum="CE461CA28E81ED31" modified="2001-03-01" version="1">MTRPTLSTYVDEMGNQVLLACGMAAGPLFTVAYLLQGASRVGYRPFRHPVSSLAFGRAGWVQTVNFLLAGLLPLVFAVGLWRVGFSRWGALLIGAWAVGLLGAGAFRTDPVANSTGFGPPAFGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC68</accession>
    <name>Q9FC68_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7118</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631179.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972025.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7118"/>
    <dbReference type="GeneID" id="1102556"/>
    <dbReference type="KEGG" id="sco:SCO7118"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7218"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088151_0_0_11"/>
    <dbReference type="OMA" id="TYETHER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="53"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="27894" checksum="8067E23FD931058E" modified="2001-03-01" version="1">MHPVITGAPVSRPDQDSYAVTAEFYDILQADRDAARVRDLYGRHVARARLGVLDIGAGTGRVTLMSLAESAADVHAVEPARAMRTSLLTRLATLPARQRERVTVHPYALDEAALYAAADVAVCHNTVACLPPAARDALWPAIHTALAPGGTLLLEPPPALPPPRDVVRRLPEQRVGAHVYGGRMTMSAAGYRIRTRVDYWVRSGRHVLREHTESFWMWPASRTRLIDDLARHGFVPTPGHGDPRVLAVTRPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC88</accession>
    <name>Q9FC88_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative osmoprotectant transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1225</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625514.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977606.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1225"/>
    <dbReference type="GeneID" id="1096648"/>
    <dbReference type="KEGG" id="sco:SCO1225"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1224"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_39_0_11"/>
    <dbReference type="InParanoid" id="Q9FC88"/>
    <dbReference type="OMA" id="ACMKETA"/>
    <dbReference type="PhylomeDB" id="Q9FC88"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="55"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC01507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="504" mass="53849" checksum="574FA7EB1EA86712" modified="2001-03-01" version="1">MEREAATSPTENGPETDAAAVRRHPALFRAIKRRQNPRLRRSDITVTDEAAVKRAVKAASLGNAMEWFDFGIYAYLAGTIGRVFFPSGSDTAQLLSSFATFAVAFLVRPIGGMVFGPMGDKIGRKKVLALTMILMAIGTAAIGFIPSYDSIGFWSPLLLILFRLLQGFSTGGEYGGASTFIAEYAPDKRRGFFGSFLELGTLAGYTAAASLVTALTAVLGSDGMDSWGWRVPFLAALPLGMIGIYLRLRLDDTPAYLKLEDSNVHVSEAATAVETTARGDLAKIFRTHWRALVLCIALVGAYNITDYMLLSYMPTYLSDELDYSESHGLMILVATMVLLMLIINQVGRLSDRFGRKPVLMTGMIGFFVLSAPAFVLVQEGSLLAVSGGMLMLGLSLVCLLGTMSAALPAMFPTNVRYGSLSVGYNLSASLFGGTTPLVITALISVTGSDMMPAYYAMAAALIGVVAVACMKETAQQPLAGSPPSVQTEEEAAEMVEAQAPTPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3K9</accession>
    <name>Q9K3K9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1051</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625346.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977778.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1051"/>
    <dbReference type="TCDB" id="3.A.1.154.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1096474"/>
    <dbReference type="KEGG" id="sco:SCO1051"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1046"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045983_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K3K9"/>
    <dbReference type="OMA" id="SGMVFTM"/>
    <dbReference type="PhylomeDB" id="Q9K3K9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB96036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="357" mass="38339" checksum="CCA480F4237ECDD4" modified="2000-10-01" version="1">MAHTSQETDDGGPARGRWSAFRQSPFWPATVLVLILAAAAGFFAGSYTYSMANPTPRLIPTAVVGSYEKAGGRAFLRGLEQALNTSVRVHPYETRAAAREAIEQQEVFAVFELRDDGRDAALDVSGASGASVAELLAQTAPAVGKKLGVQVTVRDVNPLQRGDPRGLAIFYISLAAVIIGFVGAIQLSVHARALTPLERILFTVAYALLGGFVIAATVDWLLGAVDLPFAESWLILALTMFVSGMVFTMFNTMFGRWAMLPTWGLMVIIGNPSSGGAVSWPLLPSPLGVIGRWLPPGASVNAQHTAVYFQGHQHVFPFLVLAGWALLSCTVFWVWRHRHPGGREKESPEAEPEAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3U7</accession>
    <name>Q9K3U7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4398</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628567.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974584.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4398"/>
    <dbReference type="GeneID" id="1099838"/>
    <dbReference type="KEGG" id="sco:SCO4398"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4466"/>
    <dbReference type="eggNOG" id="ENOG5033DHD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092810_2_0_11"/>
    <dbReference type="OMA" id="RGAVQWA"/>
    <dbReference type="PhylomeDB" id="Q9K3U7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="23592" checksum="A139F1FC7CE75982" modified="2000-10-01" version="1">MEETIPGTEAAQIPQQRGTSLLETAVRYAEERHWDVFPGTWLVPGDGVQRCSCEDPACAAPGAHPAREDWAAQATGSATVARRMWQKQQSASILLPTGRTFDAIDVPETAGFLALARMQRMELTLGPVTLAPDRRMRFFVLPGAGAKVPDLVRRLGWAPRALDLGVLGEGAYVAAPPTRFGARGAVQWACRPTAVNRWLPDVEELISALTYACGRDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3V7</accession>
    <name>PDXH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="1">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PNP/PMP oxidase</fullName>
            <shortName evidence="1">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxH</name>
        <name type="ordered locus">SCO4387</name>
        <name type="ORF">SCD10.19c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628556.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029623.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3V7"/>
    <dbReference type="SMR" id="Q9K3V7"/>
    <dbReference type="STRING" id="100226.SCO4387"/>
    <dbReference type="GeneID" id="1099827"/>
    <dbReference type="KEGG" id="sco:SCO4387"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4455"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_2_11"/>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="PhylomeDB" id="Q9K3V7"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167761" description="Pyridoxine/pyridoxamine 5'-phosphate oxidase">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <sequence length="234" mass="26012" checksum="144580483B5366FB" modified="2000-10-01" version="1">MGGVTDRDADSAVPTADPVPFDLASMRKQYRAEGLSETELAATPVEQFARWFKQAATDGGLFEPNAMVVSTADPEGRPSSRTVLLKHFDEQGFVFYTNYDSRKARELDANPHVSLLFPWHPMARQVVVTGVARRTGRDETAAYFRTRPHGSQLGAWASVQSSVVADRRALDGAYAELAARYPEGEQVPVPPHWGGFRVVPDAVEFWQGRENRLHDRLRYVAEGGGGWRVERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K425</accession>
    <name>Q9K425_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1074</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625368.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977756.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1074"/>
    <dbReference type="GeneID" id="1096497"/>
    <dbReference type="KEGG" id="sco:SCO1074"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1071"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K425"/>
    <dbReference type="OMA" id="PMNAIPG"/>
    <dbReference type="PhylomeDB" id="Q9K425"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="204"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="451" mass="47575" checksum="79ECAB3B3203D3BE" modified="2000-10-01" version="1">MSSNPVAETVASLMPRAKEELAALVAFKSVADFDQFPRSESEGAANWIAAALRTEGFQDVALLDTPDGTQSVYGYLPGPEGAKTVLLYAHYDVQPPLDEAGWATPPFELTERDGRWYGRGAADCKGGVLMHLLALRALKANGGVPVHVKVIAEGSEEQGTGGLERYAEAHPELLAADTIVIGDAGNFRVGLPTVTSTLRGMTLLRVKVDTLEGNLHSGQFGGAAPDALAALIRVLDSLRAEDGSTTVDGLAADNTWEGLAYDEEQFRRDARVLDGVELIGSGSVADRIWARPAVTVLGIDCPPVVGATPSVQAGARALVSLRVPPGVDAAEATKLLQAHLETRTPWGARVAVEQIGQGQAFRADTTSPAYQAMADAMAVAYPGEEMQYAGQGGSIPLCNTLASLYPQAEILLIGLSEPEAQIHAVNESVSPEELERLSVAEAHFLRNYAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4L2</accession>
    <name>Q9K4L2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631357.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971839.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7302"/>
    <dbReference type="GeneID" id="1102740"/>
    <dbReference type="KEGG" id="sco:SCO7302"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7404"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_4_1_11"/>
    <dbReference type="InParanoid" id="Q9K4L2"/>
    <dbReference type="OMA" id="QRTWEHC"/>
    <dbReference type="PhylomeDB" id="Q9K4L2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="23052" checksum="BE0C4EB66F1745FB" modified="2000-10-01" version="1">MTTHHLQGSLFDQTDEVRLGPLDGLRRTRLGPGAWIDLLPGWLSGADALFERLAAEVPWRAERREMYERVVDVPRLLAFYGAGDALPHPLLAEARDALSAHYAEELGEPFTTAGLCHYRDGRDSVAWHGDRIGRGARQDTMVAILSVGAPRDLLLRPAGGGGETVRRPLGHGDLIVMGGSCQRTWEHCIPKSTRAAGPRISVQFRPHGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXN6</accession>
    <name>Q9KXN6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4321</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628492.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029578.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4321"/>
    <dbReference type="GeneID" id="1099761"/>
    <dbReference type="KEGG" id="sco:SCO4321"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4389"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013420_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXN6"/>
    <dbReference type="OMA" id="WGPPYGQ"/>
    <dbReference type="PhylomeDB" id="Q9KXN6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="566"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB93395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="867" mass="90368" checksum="67DF85FA7DB21584" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXW0</accession>
    <name>Q9KXW0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4281</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628453.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029551.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4281"/>
    <dbReference type="GeneID" id="1099721"/>
    <dbReference type="KEGG" id="sco:SCO4281"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4349"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495986_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXW0"/>
    <dbReference type="OMA" id="ASFGIGW"/>
    <dbReference type="PhylomeDB" id="Q9KXW0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="423"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="553" mass="60420" checksum="62F6AC750FB3DAA2" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY49</accession>
    <name>Q9KY49_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4815</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628972.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029884.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4815"/>
    <dbReference type="GeneID" id="1100256"/>
    <dbReference type="KEGG" id="sco:SCO4815"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4892"/>
    <dbReference type="eggNOG" id="ENOG5032U94">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093866_0_0_11"/>
    <dbReference type="OMA" id="ARRWHYE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176756" evidence="2">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="22583" checksum="591B122E0D83ED3F" modified="2000-10-01" version="1">MTPTRRSVLLSVGAVGAATALGGVLTGPAAAADGTWDSPRSANGWAMDPDAVGSFRVEGSPATVRLHRAAAPVLLHVARRWHYEVIPLRGSRHVLGHRTDRAVGAAYESNYLSGSAIALLGAGDGLWPHQEAVVRDILADCGGVVRWGTDLSPADACHFQIDVGPDAKALRRLTEIFHARSVHHDGPRPGAVEDPATPERRAGARRLAKAQARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY91</accession>
    <name>Q9KY91_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5011</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629163.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030001.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5011"/>
    <dbReference type="GeneID" id="1100452"/>
    <dbReference type="KEGG" id="sco:SCO5011"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5090"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056917_4_0_11"/>
    <dbReference type="InParanoid" id="Q9KY91"/>
    <dbReference type="OMA" id="ITLRQMD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045980">
        <property type="entry name" value="DUF5936"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19359">
        <property type="entry name" value="DUF5936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5936" evidence="8">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="157"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB92604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="32764" checksum="3BDA1EA5DD2BB7F4" modified="2000-10-01" version="1">MPPALPAVLLALLMALAVWGVFAGVRMYRAEAKLPDDLALALEVGATRTGAAHSLIDRMGMRYAPAVLRLMGPALVARYRRRIDLAGNPGGLTIDRYAARRAVYGFLGALGFLVFLLRGQYLVALLLLAFGAFWTEAGIWSAIRIRKDVIERTLPDFLDVLAVVVSAGLGFRQALDRVSTRYEGPWADELRITLRQMDLGMSRREAFTELRRRNDSEQVAMFVTALQQGEELGAPIVDTLVSLAKDMRRTDAQNARRKAARAVPKATLMITTFMVPATMILLGAGLILGSGTDFGTITGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI4</accession>
    <name>Q9KYI4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SCO2688</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626922.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976111.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2688"/>
    <dbReference type="GeneID" id="1098122"/>
    <dbReference type="KEGG" id="sco:SCO2688"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2744"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KYI4"/>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="PhylomeDB" id="Q9KYI4"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="308"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAB92254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="381" mass="39437" checksum="6D94B85AEB5995E7" modified="2000-10-01" version="1">MRRALELAGAEVGSTGSNPAVGCVLLDAEGTTVATGVHRGPGTPHAEVDALRRARGRHRGTTAVVTLEPCDHQGRTGPCSKALIEAGVRRVLYAVADPNRVAAGGARRLADAGVEVVGGVLGAEAEAVLEMWLTAVRAGRPFVTWKFAATLDGRSAAADGSARWISSAESRADAHELRARHDAVLVGSGTWRSDDPRLDLRHGVVGHPPLRIALDARGELPPDSRLLDGAAPTLVVTDPATGTADHGESESNNNSGINTSTNTSTSRGANSGPDVLRLKTDARGHFPPLDLLAALDGRGVRSVLVEGGPALAASFVRAGLVDRVVAYVAPLLLGSEGVSATGPLGIGSIREAHRFRITSVDRIGPDLRIELRPPARTGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYT2</accession>
    <name>Q9KYT2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5683</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629811.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030388.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5683"/>
    <dbReference type="GeneID" id="1101122"/>
    <dbReference type="KEGG" id="sco:SCO5683"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5771"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9KYT2"/>
    <dbReference type="OMA" id="SWELSAY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="303"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB91119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="398" mass="41816" checksum="DC9051F77D0704CA" modified="2000-10-01" version="1">MSTSPPQRLRDWIAAPAYPWITGGAVTAGAVVELIVIPGGVTTTVGVLVSAVSLMWRRSFPPVAVLTVAAGLIGFAGDVNLYLAIMVSGLTGCYSLGRNRVLHPALTVTGGALGALCVNLVHINTWSRMDLPVPALWERGSLSLFAESFLVTVVVFGAVMMGDAVRSREETRTERSLAQAQLIAMERQQAAEAERAAIARELHDIVSHSVSMIAVQAESATYTTPGLTPEARDGFQQIAATARSSMAELRRLLGVLRTPQGESALTSPQPTLDHLAELVDQHRAVGGTAELRITGERVALPAAWELSAYRIAQEALTNARKHAPGARTVVEVDYGADRLLTLRVQDDGPGTDSRPGAGAGHGLTGMRERAALVGGRLSAGAGPDGGFLVEAELPWGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ22</accession>
    <name>Q9KZ22_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2215</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626466.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028203.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2215"/>
    <dbReference type="GeneID" id="1097648"/>
    <dbReference type="KEGG" id="sco:SCO2215"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2252"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="InParanoid" id="Q9KZ22"/>
    <dbReference type="OMA" id="ANPWART"/>
    <dbReference type="PhylomeDB" id="Q9KZ22"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="334"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="425" mass="45360" checksum="6058ED234021A763" modified="2000-10-01" version="1">MSIETQSSTQGPRTRGRAGNVALSGARGLALMFISLPGAVICFCFTLVSIALIPIGVGIVTTPWVLAGVRSFADRRRLLAAEWGGVRIPRAYRPLPEDANPWARTFGMLRDPATWRDIRWLPVDMTAGFVTALVAFALPLYPLEGFAIAAGLWRVLPDGYWYGFVKVTDQTSAFYAAGLGAVLLVAALWLAPLLLRAHFRLTGAVLGSGQGELAERVRVLTETRRDAVDTSAAELRRIERDLHDGAQARLVAMGMDLGTIEALLEKDPEKARELLAQARRSSADALTELRELVRGIHPPVLAERGLGDAVRALALRLPVTIEVEVDLPGRAEAPVESAAYFAVSEILTNAVKHSGADRIWIDIHHGEGLLRVSVTDNGKGGASIGAGSGLAGVERRLGTFDGVLAVSSPAGGPTMVTMEIPCVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ36</accession>
    <name>Q9KZ36_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631157.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972047.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102534"/>
    <dbReference type="KEGG" id="sco:SCO7096"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7196"/>
    <dbReference type="HOGENOM" id="CLU_148719_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="13101" checksum="CF5421E9007EB0B9" modified="2000-10-01" version="1">MDAKDEAERGLTVIQDYLYWDSHRRAAHHRAAEFAAHVPGLSEEQKTDLEWWYVEEQIRVSRAIAHHLTEQITMVEARHTRRYARLRRMSRVALAVLAATVMVLLVALVLVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZC4</accession>
    <name>Q9KZC4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6965</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631031.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972181.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6965"/>
    <dbReference type="GeneID" id="1102403"/>
    <dbReference type="KEGG" id="sco:SCO6965"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7065"/>
    <dbReference type="eggNOG" id="ENOG5032S3Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150609_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZC4"/>
    <dbReference type="OMA" id="WEDFHRV"/>
    <dbReference type="PhylomeDB" id="Q9KZC4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="PTHR40630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="12378" checksum="DBBD70EC1749BAA4" modified="2000-10-01" version="1">MADALELDALWEDFHRVVNMTSAELADWLRVRDSGELTEPLPDDAGPPLGQHVLAILQKRRTDLTGDDLRAMRKVVDTVTSQTDLENEPAAEDTRLRHRLMTVGHDPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZL2</accession>
    <name>Q9KZL2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627254.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028724.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3032"/>
    <dbReference type="GeneID" id="1098465"/>
    <dbReference type="KEGG" id="sco:SCO3032"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3092"/>
    <dbReference type="eggNOG" id="COG3147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031881_0_0_11"/>
    <dbReference type="OMA" id="DYVHLTN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043777">
        <property type="entry name" value="DUF5719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18986">
        <property type="entry name" value="DUF5719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176789" evidence="2">
        <location>
            <begin position="23"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="506" mass="50358" checksum="14CE810B8952F4AB" modified="2000-10-01" version="1">MKRTTLSLIACATALAAVTGFAAVSAPGDAGTDTAAPAARLPVERTGLLCPAPSTSDLAETAYTSFTPVTQGADEKGSAALVAAESADATEDGKDGGKSDEKGGKDGQQEKPVLQPKAPGTPVAGKATGAGAPALIGTAEGSSAPGWTVQQTTEVAVGTGRGLQGVNCTAPDTEFWFPGASTAAGRTDYVHLTNPDDSAAVVDIELYGKDGALKSTVGEGVTVPPHGSESLLLSTLSDVKQTDLTVHVGVRSGRLGAAVQALDDKTGGDWLTAAADPAGDLVLPGIPKDATAVRLVLFTPGGTDADLKVRLASPSGLITPAGHETVHVKAGMTTGVDLGEVTRGEAGSLVLTPTDRSVPVVAAVRVVRGKGDEQESAFIPASDPVGARATVADNRAKSTTLALSAPGKAAKVKVTASAGTEGGTTATKTYTVGAGTTQNVDAPVPAGLKGSYALTVETVSGGPVHASRTLTGSDDDVAAFTVQTLPDDRGTVSVPNADEDLSVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZM3</accession>
    <name>Q9KZM3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3021</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627243.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975790.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3021"/>
    <dbReference type="GeneID" id="1098454"/>
    <dbReference type="KEGG" id="sco:SCO3021"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3081"/>
    <dbReference type="eggNOG" id="COG1714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054176_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KZM3"/>
    <dbReference type="OMA" id="WMLTGGP"/>
    <dbReference type="PhylomeDB" id="Q9KZM3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="32815" checksum="AA638B2C49C23DCC" modified="2000-10-01" version="1">MSELVTGEAVALELRPARLPSRALAVLLDLAVAVAVYVAVTIALMVATASLDVAAQTALSIATFVLVLVGGPIAVETLSHGRSLGKMACGLRVVRDDGGPIRFRHSLVRGLIGVIEILMTLGVIACVASLVSARGRRLGDVFAGTLVVRERVPFSSAGFMPPPPPWLAGRFSGLDLSAVPDDLWLAVRQYLARMGQLDPRVGWAMAERLAADVAARTGAPVPREVPPPAYLAAVLQERQAREARRAFGGASAEGTAAWAVPVAPAPPARPAVPTAPPPVPTAPPTAPPPAPPSPGGGLEVPRDVPPDRRPGTGFVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZS7</accession>
    <name>Q9KZS7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2874</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627102.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975935.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2874"/>
    <dbReference type="GeneID" id="1098308"/>
    <dbReference type="KEGG" id="sco:SCO2874"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2934"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_11"/>
    <dbReference type="InParanoid" id="Q9KZS7"/>
    <dbReference type="OMA" id="VHPGNMV"/>
    <dbReference type="PhylomeDB" id="Q9KZS7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-keto sterol reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="34066" checksum="6A8D5596BF4399F2" modified="2000-10-01" version="1">MTHTEQQPLNSPFSAATTAEDVMAGHDLSGVTAVVTGGYSGLGLASTRALTAAGARVLVPARRPDIARAALRDVKGSEVVPMDLTDLDGVRSAAAHIGDRIDRIDLLMAAAGVMATPERRVGPGWEFQLAANHFGHFTLACELYPLLAAAGGARVVAYSSAGHAMTDIRRHDPHFRTGYDRWLAYGQAKTANALFAVHLDALGKDDGIRAFALHPGKIITGLQREMPLQEQIDAGWVDEHGNVVAADFKTASQGAATGLWAATSPLLDGRGGLYLADCDVARVFPPDTPMDDNGVRPYAVEPANAARLWEMSLAATGATPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0H9</accession>
    <name>Q9L0H9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4778</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628936.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029857.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4778"/>
    <dbReference type="GeneID" id="1100219"/>
    <dbReference type="KEGG" id="sco:SCO4778"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4851"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="InParanoid" id="Q9L0H9"/>
    <dbReference type="OMA" id="ISRGHFT"/>
    <dbReference type="PhylomeDB" id="Q9L0H9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="39232" checksum="3F3D7A7B8D0F041B" modified="2000-10-01" version="1">MGRMVTEGAGGRVIAGRYRLHERLGRGGMGIVWRATDQLLAREVAVKALPLDESLSAAEARRRRERTLREARAVAQLRHPHVIVVHDVVEDDGRAYMVMELVDGGSLADRVLTRGPVDAVEAARIGVALLDALDTAHASGILHRDVKPSNVLVADDGRVVLTDFGVAQVAGATTLTESGSFVGSPEYTAPERMSGAGTGPESDLWSLGVLLCAVLSGASPFHRDSLGGVLHAVVTEEIRPPAQAGPLLPVVRGLLERDPRRRLDAASAQRMLRAFLSTGRTPATPEEATAARPLRARRSVKRSVLLAVLLVVAAAGAGVSAAALFADGGDDGGGTPTSSVPATPTSTPPTSTPPTSTPTTATPTTANPGPPAASGSGNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0L9</accession>
    <name>Q9L0L9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transmembrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4641</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628802.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029787.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4641"/>
    <dbReference type="GeneID" id="1100082"/>
    <dbReference type="KEGG" id="sco:SCO4641"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4712"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q9L0L9"/>
    <dbReference type="OMA" id="GLRMLPW"/>
    <dbReference type="PhylomeDB" id="Q9L0L9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="18"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="490" mass="50164" checksum="0DC9D5013A63DBCC" modified="2000-10-01" version="1">MSQQGARRNTRGGGAAWALVITSVAGFMAALDNLVVTTALPSIREDLGGALHDLEWTVSAYTLTFAVLLMFGAALGDRFGRRRLFLVGLTVFTGASAAAAMAPGIDSLIAARAVQGVGAAIMMPLTLTLLTAAVPAERRGMAYGIWGAVNGLAVASGPLVGGSLTEHISWQWIFWLNVPLGLALLPLARLRLAESHGTGAPLDIPGTLLASGGLFGIVYGLVRGPVDGWTGSVVLTALFAGAALLVGFVLYSTRARNPMLPMRLFRSRAFAGVNAASLLMFLGMFGSIFLLSQYMQGVLGYSPTEAGLRMLPWTGMPMLVAPIAGLLSDRIGGRPVVATGLFLQAAGLGYLASVIMADASYAVQLPGLILSGIGMALYFAPASALVMSSVAAKEQGIASGANNALREVGGALGIAVMSSIFAAQGGYESAQTFVDGLRPAIAVGAALVALGGIAALAIPARRRTDGPTAAPKTEPKTEPALATTAPTPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0U0</accession>
    <name>Q9L0U0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4504</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628668.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974444.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L0U0"/>
    <dbReference type="STRING" id="100226.SCO4504"/>
    <dbReference type="GeneID" id="1099944"/>
    <dbReference type="KEGG" id="sco:SCO4504"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4577"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060397_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L0U0"/>
    <dbReference type="OMA" id="WYSSIHT"/>
    <dbReference type="PhylomeDB" id="Q9L0U0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="23523" checksum="56A7D99F1E7FEA3A" modified="2000-10-01" version="1">MTVDPAFVATTRTFYDAVAEDYHARFRTVLDDAPLDRALMGAFAELVGPEGQVADLGCGPGLVTAHLASLGLRVFGLDLSSSMLAIARRENPGLRFEQGSMLDLDLPDGALAGAVSWYSSIHTPWERLPDLFGEVRRVLAPGGHLLLGFQVGDEPRHHDRPWGHPVALDFERRRPEPMAELLERAGFTVLSRTVRITEETTVAQVPQAFLIARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L145</accession>
    <name>Q9L145_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631463.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031647.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7414"/>
    <dbReference type="GeneID" id="1102852"/>
    <dbReference type="KEGG" id="sco:SCO7414"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7524"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084148_0_0_11"/>
    <dbReference type="OMA" id="MHRAMGF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="268" mass="29747" checksum="3503FA3F4C1EE802" modified="2000-10-01" version="1">MNRLWRPFHRVWDWLAASALVRRGRDLELMHRAMGFATLALVTLAPLLIVVAAADPLGRGGFASWLADGMGLSGRSAKVLTDIISPPTKVVGTTSVWGGILLGVFGVSFAASVQNGYERIWELPSGPWHRIWRQMTWVALLTAYLYQEVQTRTALHGSARIALSTASGMLFFWWGQHFLLGGQVRWRDLLPGAVATMVGLIGLRGFSYLFFTPLILDNAFSYGAVGIVLVVESWLIGVGFVVFGGAMVGHWFCEHHWWARNIDRRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1B9</accession>
    <name>Q9L1B9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1563</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625841.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027850.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1563"/>
    <dbReference type="GeneID" id="1096994"/>
    <dbReference type="KEGG" id="sco:SCO1563"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1575"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096795_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1B9"/>
    <dbReference type="OMA" id="YRIDPLV"/>
    <dbReference type="PhylomeDB" id="Q9L1B9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017189">
        <property type="term" value="P:N-terminal peptidyl-alanine acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="17395" checksum="D74882A5F924B827" modified="2000-10-01" version="1">MTISAATDQDAEQIFRLQYLCFQSEAALYANYRIDPLVQTLDSVRQEVAADCVFVARLGDEVVGSVRGRVTEDGAASIGKLCVHPRLQGHGIGARLLRAAESSLGGERGAKRFRLHTGHRSESNLRLYRRVGYETVGTAEGADGVPMIVLEKPAGTYATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1T4</accession>
    <name>Q9L1T4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2961</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627185.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028685.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2961"/>
    <dbReference type="GeneID" id="1098394"/>
    <dbReference type="KEGG" id="sco:SCO2961"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3019"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038663_0_0_11"/>
    <dbReference type="OMA" id="VRVVVYH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="24"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB72207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="401" mass="45620" checksum="5A0E9F40091C4596" modified="2000-10-01" version="1">MGTDTDVPVAPQQEQARRAPVRDRYFDLLRAVALFRVVLYHLMGWAWLPVVFPSMGVMFALAGNLMARSLKRPAVQVVRSRMRRLLPPLWLLGVVGVTGMVLQGWGPSEDGHPGWWWFHLLYWVLPLSDPPFAESVPGIHGILGEDWAAELGGPLWYIRAYLWYVLLSPVLLRALRALPWLTILAPLALSAAFQFGYLNLPGERFPSALTDFSTFGACWVLGMAHQEGILKRLPRYVVPSVAPVIAALGLWYAFREGFKTGYDLDSIPFAQAVWSFATVLLLLHVSPSWTEWPRRLRRWDRLITLLNSRAVTIYLWHNVCILIAATLWDQLWGFEVMYENVPWLLESPWPVLAIAWLLIGSCIVWFGWMEDVAAKRSPQLWPDGGKRTAPKRPRARAAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2D5</accession>
    <name>Q9L2D5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2484</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626726.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028379.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2484"/>
    <dbReference type="GeneID" id="1097918"/>
    <dbReference type="KEGG" id="sco:SCO2484"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2526"/>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640777_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L2D5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033299">
        <property type="term" value="P:secretion of lysosomal enzymes"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004328717" evidence="2">
        <location>
            <begin position="25"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="3">
        <location>
            <begin position="243"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB69772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="428" mass="44436" checksum="11A30F3D74727C38" modified="2000-10-01" version="1">MHRRAVVLFTAALLLGLGLPRASAESRQDEPTSLITSPGYTRTTASPGPGLTLFTYQNPDDDRVVHVLRADPDAAPLTVESTAGTSGARAEKTTDMLKSTTGYAPRWPHAGLNGGFWYRQGDTLAFMGISVQEGVVQSASCSAAGRGEAALIQHGRPYIGDFTTHLAVTAPGAAPMPLDGVNRHPGWMTGCAQGSGATADRSIGGGVFADASEIIAFTSRFKAPTPVPDADARFTEDDDPGAEAVVAADGTVLSLNPNGRGGVTVPTGGRVLQGTGTGADWLRAHATPGTDLAFEERLHDERFGDDIPLDSSVDVVNGHYPLVHNAQYAYTGQNTAVDPRSAIAVDGPGRTLFVTATGKSGRNGVTLDEFARILLDLGAVDGLNMDGGGSTTLVVEQAVVNRPSDSTGERPVADSLYIGHGGYGHYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2G3</accession>
    <name>Q9L2G3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2520</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626760.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976283.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2520"/>
    <dbReference type="GeneID" id="1097954"/>
    <dbReference type="KEGG" id="sco:SCO2520"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2565"/>
    <dbReference type="eggNOG" id="ENOG5032RDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072321_0_0_11"/>
    <dbReference type="OMA" id="CVDERFR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="377" mass="42362" checksum="F09A2DA1CD536CAA" modified="2000-10-01" version="1">MSTAQSPRPDDTPRTTNPIDPRGESPWTRMLLVALVAGGLFWSVAALLDPDDGTVRQFVAAVLCAAAALAVQYVLGLAPRPGPDRLDEHTRLEEHTRRVEDALAENTTAVRDGLSRYDTELKSGLTRHTEDVKQLVETHVTQADHGPAEAARALDPVRIDSVPDLAKGFADVLLPSPSILHTFVHLEMSRVVGHMADLTNLSAECPGENHDWMLTLTKAAEQSILATSTSVDRQFWNSEPAGRYLDAQQAAIDEQGVTVRRLFLLESARELDDRLLRLCEEQELRRIDVRVAVLPELPPHLQRGTTNDFILYDEEVSFEIEQDLRDVNVRTRLTARQDYVRDRLKRFRELWDAGMGLRELEVRVDDEEDGKWVVDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2G6</accession>
    <name>Q9L2G6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2517</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626757.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028400.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2517"/>
    <dbReference type="GeneID" id="1097951"/>
    <dbReference type="KEGG" id="sco:SCO2517"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2562"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9L2G6"/>
    <dbReference type="OMA" id="FETDTNV"/>
    <dbReference type="PhylomeDB" id="Q9L2G6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB69738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="24086" checksum="0897481C3709BDE0" modified="2000-10-01" version="1">MLLADDQNLVRAAFALLVASAPDMEVVGEAGTGRQAVELARARRADLVVMDVRMPDLDGIEATRLIAADEDLAGVRVLVLTTYDTDENIVEALRAGASGFLVKDTRPAELLEAIRTVTAGDALLSPGPTARLIERFLRSPSALHPPGSGPDCLSERERQVLTLVARGLNNTEIAEALGLSPLTAKTHVSRIMGKLEARDRAQLVIVAYESGLVTPGAGQSQQTSQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2H8</accession>
    <name>Q9L2H8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">High-affinity zinc uptake system protein ZnuA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2505</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626745.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976297.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2505"/>
    <dbReference type="GeneID" id="1097939"/>
    <dbReference type="KEGG" id="sco:SCO2505"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2550"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L2H8"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="PhylomeDB" id="Q9L2H8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01019">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035520">
        <property type="entry name" value="ZnuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329904" description="High-affinity zinc uptake system protein ZnuA" evidence="8">
        <location>
            <begin position="34"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB69726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="328" mass="35176" checksum="E4A29AC83DE48BDF" modified="2000-10-01" version="1">MNVRRRRISGIAVTAATALGLGTLSACSSDSSAAGNTDKFDVVASFYPMEYLAEQIGGDHVNVTTLTEPGQEPHDLELSAKQTARMGEADAVLYLKSLQPAVDEAIAQSDVKTKIDAASLTKLEDHGNVEHDHDHGGEEHADEHAEEEHSEGGEHALDPHVWLDPVKYAEIAQGVAESFEKADPDHAGDYRKNAEALAKKLSGLDTAYKDGLKNTATKVFFTNHAAFGYLAERYGLTQEAINGLDPESEPSPARIKELQQEAKADGVTTVFYETLVSDKTAKTLAKDAGLKTDVLDPLEGITDKSKGEDYVGVMEANLKALETALGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD04</accession>
    <name>Q9RD04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0907</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625206.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027435.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0907"/>
    <dbReference type="GeneID" id="1096330"/>
    <dbReference type="KEGG" id="sco:SCO0907"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.901"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_4_11"/>
    <dbReference type="InParanoid" id="Q9RD04"/>
    <dbReference type="OMA" id="AWVQSTT"/>
    <dbReference type="PhylomeDB" id="Q9RD04"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="168"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="30320" checksum="DCBB9B266CE515A5" modified="2000-05-01" version="1">MTDQLTVSVLGTGIMGAAMARNLARAGHAVRVWNRSRAKAEPLAADGAHVAGSPEEAVRGADVVLTMLYDGPAALDVMRRAEPGLRPGTVWAQSTTAGVDAVADLAAYAHERGLVFFDAPVLGTRQPAEAGQLLVLAAGPGEARDTVAPVFDAVGSRTVWTGEDGAAGSATRLKLVANSWVLAVTNAGGETLSLAKALGVDPDTFFDAIAGGPLDMGYLRAKAGLIRDGALRPAQFAVATAEKDARLIVEAGEANGVRLDLAAAGAERFARAAAQGHGDEDMAAAYFASFEEKASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD36</accession>
    <name>Q9RD36_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0873</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625173.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027408.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0873"/>
    <dbReference type="GeneID" id="1096296"/>
    <dbReference type="KEGG" id="sco:SCO0873"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.864"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2398222_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="93" mass="9838" checksum="CD0BC2433BDFDF41" modified="2000-05-01" version="1">MTNPWTASEKCSCAAIGVSRCSAGGQEDGRASLCMRRAIPAVVLADAAMGEIAQARRDRMEGTRFGDVKGYDGAPLPAPELPPVPLKPRGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD86</accession>
    <name>Q9RD86_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0791</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625092.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027357.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0791"/>
    <dbReference type="GeneID" id="1096214"/>
    <dbReference type="KEGG" id="sco:SCO0791"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.783"/>
    <dbReference type="eggNOG" id="COG4129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037626_2_0_11"/>
    <dbReference type="OMA" id="MALMAPW"/>
    <dbReference type="PhylomeDB" id="Q9RD86"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="40495" checksum="4759BEE452A7FD9F" modified="2000-05-01" version="1">MWWEACAVGRAVRAAWRGPGRERDLVVQSLKAAGAALIAWTVAGVWLGDPMALMAPWVALVLVQATVYSSVRQAGQQFAAICTGALLASAAQAIMDDNTGALVLSLPVLMLVANWSRFGGQGIYAATTAVFVLASGTAVSAAAVGHRMGQAALGAVIGVAVNALVLPPIHLRDVRENLAALAREAGDLLHSVAADLRETQWDAQSAAGWTSDAARLERRLEALYSARSWSRESLRLTSGRLRRLHRAPTVVPPEDEDRRWSRVTGNLGALTRTLAVAADEHRTPAPPEGPVLDLYARLLRLIGDACHTEAGRWAGERPGADPATATEETMEELHRRLQEGLREHAGQGAARTAVLGTLLLQAENLWAEIVPEPRESAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDG9</accession>
    <name>Q9RDG9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-N-acetylglucosaminidase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2758</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626989.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028566.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2758"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="GeneID" id="1098192"/>
    <dbReference type="KEGG" id="sco:SCO2758"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2814"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_11"/>
    <dbReference type="InParanoid" id="Q9RDG9"/>
    <dbReference type="OMA" id="STDQEHG"/>
    <dbReference type="PhylomeDB" id="Q9RDG9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176873" evidence="4">
        <location>
            <begin position="41"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="58"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="6">
        <location>
            <begin position="437"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB66297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="615" mass="64482" checksum="5219AE100AF99CD9" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI30</accession>
    <name>Q9RI30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nitrate reductase delta chain NarJ2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0218</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37047">
        <property type="entry name" value="T37047"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624551.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026934.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0218"/>
    <dbReference type="GeneID" id="1095642"/>
    <dbReference type="KEGG" id="sco:SCO0218"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.192"/>
    <dbReference type="eggNOG" id="COG2180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084469_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RI30"/>
    <dbReference type="OMA" id="YGDTRKR"/>
    <dbReference type="PhylomeDB" id="Q9RI30"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016530">
        <property type="term" value="F:metallochaperone activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="28721" checksum="EAFA80F543193D10" modified="2000-05-01" version="1">MSPLPTTVPDIVRARVRAALRRPDGTARSGRAAASFGPREPETRALLLRLLSLLLQYPDAALTAARPVLTATVEALPPSPATEHLSTFTTWFTGQEPDALEQHYVETFDLRRRSGLYLTYYLHGDTRRRGMALLTLAQRYRATGWDTDGGELPDHLPVVLEYAALAGPRAGEAPLRLHRRGLELIHHALSDGGSPYRHVLAALLTLLPPATEADRAAVAELAAQGPPAEDVGLDPYGAGGFTPPGAFVPPEQAHPTLMPPLTPPEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK1</accession>
    <name>Q9RJK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bi-domain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0387</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027076.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0387"/>
    <dbReference type="GeneID" id="1095810"/>
    <dbReference type="KEGG" id="sco:SCO0387"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.363"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024115_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJK1"/>
    <dbReference type="OMA" id="YVRWTER"/>
    <dbReference type="PhylomeDB" id="Q9RJK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="726" mass="76454" checksum="DFEB0B87CF9EEEE4" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJP3</accession>
    <name>Q9RJP3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="5" type="ordered locus">SCO0601</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624913.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027236.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0601"/>
    <dbReference type="GeneID" id="1096024"/>
    <dbReference type="KEGG" id="sco:SCO0601"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.583"/>
    <dbReference type="eggNOG" id="COG1273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048975_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RJP3"/>
    <dbReference type="OMA" id="QVKGYPR"/>
    <dbReference type="PhylomeDB" id="Q9RJP3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="347" mass="38697" checksum="282EA2276DB7D347" modified="2000-05-01" version="1">MARAIWTGVITFGLVSVPVGLFTATEDHTVHFHQLQRGTSDRIRNRRVNERTGKEVDADDIVKGYEVSEGEYVVVQPEELDEIAPGRSRTLEITDFVDLDRIEPVYFGRTYYLAPRGKEYLKVYELLRTALADTGKAGVATFVMRNRQYLTALRAEDRVLLLQTLHWADEVRDPVEELPELPSDRVGRGKELDMALRLVDALSGDWEPARYRDTYQDKVRELVRAKAEGEEVAVAEEAPGATNVVDLMEVLRGSLEQAKGAGTGGKRSAASRKKATEPSRRTPAERGGLRELSKAELYRRATEQGIAGRSKMSRQELVDALTDRDHGRGRGTGSGSRGRRKKTTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJX6</accession>
    <name>Q9RJX6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1194</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625484.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027644.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1194"/>
    <dbReference type="GeneID" id="1096617"/>
    <dbReference type="KEGG" id="sco:SCO1194"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1193"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_11"/>
    <dbReference type="InParanoid" id="Q9RJX6"/>
    <dbReference type="OMA" id="MIANQAL"/>
    <dbReference type="PhylomeDB" id="Q9RJX6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="24"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="496" mass="50938" checksum="61CD995728B8589E" modified="2000-05-01" version="1">MSIPHGAASAAARPDRVDPAVRRIGATLVVGALGVVFDTTVVSVALDDLAKAFDAPLATVQWVSTGYLLAVFVTIPLAVWAQARFGGRRLWIAALGGFLLGSVLSALAWNATSLIVFRVVQGLAGGIMMPLMATLLMQAARGSHPGRVMAIITVPTALGPILGPVLGGLVLHLADWRWMFFVNIPFCVVGGWLALRNLPDDRPEPGGPRGRLDVVGLLLLCPGVAALVYGLSRVEGGAGTTGAAVLVPLLGGLALVGGFTARSLTRPGGALIDLRLFRHRAVASSAALLFLGGIALYGPMMLLPLYFQQVRGEDALGAGLALIPQGVGALLARALAGRYMDRVGPRRVAVTAFALVAVATVPFAFVTAGTGGAVLMAALFVRGIALGAAMIAPMGAAYVGLRHQEIPDAGVITRVAQQIGGSVGIALLAVVLQHAAAGAHGPSALAGAFDRAFWWSAVLTALAVPLCLLLPGRPEPPPPARTTRTGEAVDPRRPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK32</accession>
    <name>Q9RK32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0684</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB60465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624992.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027292.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0684"/>
    <dbReference type="GeneID" id="1096107"/>
    <dbReference type="KEGG" id="sco:SCO0684"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.670"/>
    <dbReference type="eggNOG" id="ENOG50318UG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061329_0_0_11"/>
    <dbReference type="OMA" id="CHLGALY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB60465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27387" checksum="A816BC0A3CE68207" modified="2000-05-01" version="1">MTTTWTTHETTSEALGVLAAEGATGALSGERGIVYLSAGRVVHVESAFTPDLGALLTRSGAVPPDGWWDAVDRGGAQHRVGHRLVDSGRLTAGALEVCHLGALFDAAYFVLAHDARAQRFRPGAVHWLGAVRSVPVDVVVRESGRRRALLDRIWPDPAIDTLPLTRVPGADTAELPVRRGRTLTQVDGVRTAAQIASALACRTYHTLVELRRLAADGLVRAAPPAAPPVVPGPAPSAVVWDDPDTALLRRLRDALEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKC4</accession>
    <name>Q9RKC4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3163</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627379.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975653.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3163"/>
    <dbReference type="GeneID" id="1098597"/>
    <dbReference type="KEGG" id="sco:SCO3163"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3223"/>
    <dbReference type="HOGENOM" id="CLU_161984_1_0_11"/>
    <dbReference type="OMA" id="WHVELEF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="91" mass="10135" checksum="CDA846493B1ABC7C" modified="2000-05-01" version="1">MMHTTVGWHVELEFTEDDQHTRAVAMVRLPDGTEVRAHGHASRHRVDSRQPRVGEEVAGARALNELAMQLLTKAHDEIDAASGRTSHPIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKM4</accession>
    <name>Q9RKM4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628283.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029435.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4103"/>
    <dbReference type="GeneID" id="1099540"/>
    <dbReference type="KEGG" id="sco:SCO4103"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4162"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_11"/>
    <dbReference type="InParanoid" id="Q9RKM4"/>
    <dbReference type="OMA" id="ECSCANV"/>
    <dbReference type="PhylomeDB" id="Q9RKM4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="199"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="423" mass="44795" checksum="0657D768E9BD3199" modified="2000-05-01" version="1">MSDTARTVLAGLGSVRSDLEDLYQDLHRHPELGLREHRTAKKAAESLRRSGYDVTEGVGGTGVIGVLANGDGPVVMARADMDALPVRERTGLPYASTATVTDEDGREQPVMHACGHDVHVTSLVGCARLLAGHRDDWRGTFVALFQPSEENGAGARAMVEDGLTDRSPRPDVVLAQHVLPYPAGYVGTRSGSFLSAADSLRVTVHGRGAHGSAPQASVDPVVIAASVVVRLQTVVSRELAATTPAVVTVGSIHAGSGPNVIPDRAVLELNVRTYDDATRTQVLDAIKRIVRAECEASRSPREPEFERLSTFPPTVNDEEPTRRVAEAFGVYFGDDAHTVELQTASEDMSEIPGAFGVPFTYWAIGGTDPDRYAEAARKGTVAQDIPVNHSAAFAPVVQPTLDTGVSALTVAALAWLGDGDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL08</accession>
    <name>Q9RL08_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0310</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978556.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0310"/>
    <dbReference type="GeneID" id="1095734"/>
    <dbReference type="KEGG" id="sco:SCO0310"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.285"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_3_1_11"/>
    <dbReference type="OMA" id="SYITSAH"/>
    <dbReference type="PhylomeDB" id="Q9RL08"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="24238" checksum="9C8EE6BFC5C82270" modified="2000-05-01" version="1">MDMKPEDRRVRRTRAALRKALVELVLDKGFQAVTVEEITERADIGRATFYAHYRDKEDLLVGIVRDLAQDRERLLPAVRQAHAQGFTGLPVKYIFEHAAQERGVYQVILRGEGDGRALREFTELIRSHAEMAFRDRARQLGVEPRIPLGIVARAWTGELISVLGWWVENDTGYTAEQITAHLRDLSVYGRVWATGLTPVDAPGAVDLPGGRGAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1W1</accession>
    <name>Q9S1W1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0031</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37095">
        <property type="entry name" value="T37095"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624389.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095464"/>
    <dbReference type="KEGG" id="sco:SCO0031"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.26"/>
    <dbReference type="eggNOG" id="ENOG5033TS7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509795_0_0_11"/>
    <dbReference type="OMA" id="WSMLGAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="19798" checksum="32CD365F5A3515E7" modified="2000-05-01" version="1">MSDAFTVLWTHDVCRALRRAGRVGERPPVAFIGVHSSLPAWTGAGAGDEVYALHVNRREVFVVSRMRVIDRERHGCCGTAPATWEDPAYPGHHDWSMLGAEGCGADPVHVDATPVRFDTPISGDLLARLTWRNRRGQTRQLKYVVDGRLENSVSLQGFYRLTPESSAELADVTASAVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2A4</accession>
    <name>Q9S2A4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36748">
        <property type="entry name" value="T36748"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625999.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977100.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1726"/>
    <dbReference type="GeneID" id="1097157"/>
    <dbReference type="KEGG" id="sco:SCO1726"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1744"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044189_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2A4"/>
    <dbReference type="OMA" id="CQVDCVL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045969">
        <property type="entry name" value="DUF5925"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19347">
        <property type="entry name" value="DUF5925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="178"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="39338" checksum="0E3F4DBA8CB32E96" modified="2000-05-01" version="1">MSVNPHEALPIRLNVDDSDSPSDVVDALFLGRFATGEQPYSHAANIDRVRSGATLLPPGARVLRIARDDDRSATLAEGDGWTLLISRWSRGADVTVTATSADLAEKVLGEATDGAADEPEPQPENVTMGFWYVSPRRGPHRTTRQIAAGTWDEVRANYTAPVADAMDGLMKTTPEDIAGRLLLLHGPPGTGKTSALRTLARSWRDWCQVDCVLDPERLFSDVGYLMDIAIGEEDAAGKGRWRLLLLEDCDELIRGEAKHTAGQALSRLLNLTDGLLGQGRNVLVGVTTNEDLERLHPAVVRPGRCLARIEVGPLSRREAVDWLGTEEGVGREGATLAELYALRRGTSPTALPEPRAGAEAGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Y5</accession>
    <name>Q9S2Y5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2030</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34873">
        <property type="entry name" value="T34873"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028107.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2030"/>
    <dbReference type="GeneID" id="1097464"/>
    <dbReference type="KEGG" id="sco:SCO2030"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2061"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060257_0_0_11"/>
    <dbReference type="OMA" id="HQSSYGR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="392" mass="40743" checksum="FDFADF91D1894399" modified="2000-05-01" version="1">MTPPTQDHSTAASLDERVTGALVGAAVGDALGGPVEGYSPEQIVERHGGRVHGVVGPWNGDAWRTARPVAPYHKGDGHVTDDTLMTHALVRVYGTVRDHLDAYAVAEHLVPDLITNPRWIPELEAEALPLQRIFLAEKWLVARIHYGHVDPREAGTGNIVNCGAAMYMAPVGLVNAAHPAAAYAEALDVAGAHQSSYGREAAGVFAAAVAAACAPGATPDSVVAACLALAKDGTRAAIEAVCEVAACHSDFESALAPLRAAVAPYDTVGPDYRAPSLGARRPSRLHAIEELPVALGMLLVAGGDFRHAVLGAVNYGRDCDSIATMAGALAGALGSPVPEDWAKTVAEASRLDLWEPAAVLTAVAREVFARDVRRRRAHEEAFAAIGGVGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7M9</accession>
    <name>Q9X7M9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6723</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35248">
        <property type="entry name" value="T35248"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630796.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031134.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6723"/>
    <dbReference type="GeneID" id="1102162"/>
    <dbReference type="KEGG" id="sco:SCO6723"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6830"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064269_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7M9"/>
    <dbReference type="OMA" id="FFDRRHG"/>
    <dbReference type="PhylomeDB" id="Q9X7M9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177001" evidence="2">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB40673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="348" mass="36509" checksum="BAB2596684271BC5" modified="1999-11-01" version="1">MALAGAVCAAALAALTAVPAQAHQRPQWDVQDTGVFDVRFRGLAAVSRHTAWVAGTGGTVLRTTDGGDTWRDVSPPGAGELEFRDIEAFDARRAVVLAIGEGEASRIYRTDDGGATWTESFRNTDARAFYDCLTFFDRRHGLAMSDPVDGKFRILSTGDGGRSWKVLPDAGMPAAQQGEAGFAASGQCLVSAGPSDVWLATGGAARARVLHSADRGRTWTATDAPVPAGDPARGVFALAFRDAAHGLAVGGDYRPGQASPRAAARSSDAGRSWRPADRPPPAYRSGVAWLPHSRSAALAVGPTGTDLTTDGGRTWRTVDTGSYDTVDCTPDLGCWAAGEQGRVARLER</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7P1</accession>
    <name>Q9X7P1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6735</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="J. Biol. Chem." volume="291" first="23175" last="23187">
            <title>Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Lalic J."/>
                <person name="Posavec Marjanovic M."/>
                <person name="Palazzo L."/>
                <person name="Perina D."/>
                <person name="Sabljic I."/>
                <person name="Zaja R."/>
                <person name="Colby T."/>
                <person name="Plese B."/>
                <person name="Halasz M."/>
                <person name="Jankevicius G."/>
                <person name="Bucca G."/>
                <person name="Ahel M."/>
                <person name="Matic I."/>
                <person name="Cetkovic H."/>
                <person name="Luic M."/>
                <person name="Mikoc A."/>
                <person name="Ahel I."/>
            </authorList>
            <dbReference type="PubMed" id="27634042"/>
            <dbReference type="DOI" id="10.1074/jbc.M116.721894"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35260">
        <property type="entry name" value="T35260"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630808.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031144.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="PDB" id="5E3B">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A=1-161"/>
    </dbReference>
    <dbReference type="PDBsum" id="5E3B"/>
    <dbReference type="SMR" id="Q9X7P1"/>
    <dbReference type="STRING" id="100226.SCO6735"/>
    <dbReference type="GeneID" id="1102174"/>
    <dbReference type="KEGG" id="sco:SCO6735"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6843"/>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054419_3_1_11"/>
    <dbReference type="InParanoid" id="Q9X7P1"/>
    <dbReference type="OMA" id="PVRYEAI"/>
    <dbReference type="PhylomeDB" id="Q9X7P1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="5E3B"/>
        </source>
    </evidence>
    <sequence length="161" mass="17370" checksum="7E49614BCC1612EE" modified="1999-11-01" version="1">MSEISYVRGDATAPSVKGVKMIAHVCNDLGGWGKGFVLAVSRRWPQPEAAYRAWHRDRAANDFGLGAVQFVQVEPYVWVANMIGQHGMKTGSKGAPVRYEAIGTALGRVADRAAELEASVHLPRIGCGLAGGTWSRVEPLISDRLTRRGIPVTVYDHGDTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7W3</accession>
    <name>DXS1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase 1</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase 1</fullName>
            <shortName evidence="1">DXP synthase 1</shortName>
            <shortName evidence="1">DXPS 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs1</name>
        <name type="synonym">dxs</name>
        <name type="ordered locus">SCO6768</name>
        <name type="ORF">SC6A5.17</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35408">
        <property type="entry name" value="T35408"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031168.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X7W3"/>
    <dbReference type="SMR" id="Q9X7W3"/>
    <dbReference type="STRING" id="100226.SCO6768"/>
    <dbReference type="GeneID" id="1102207"/>
    <dbReference type="KEGG" id="sco:SCO6768"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6877"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_11"/>
    <dbReference type="InParanoid" id="Q9X7W3"/>
    <dbReference type="OMA" id="FAPQGMF"/>
    <dbReference type="PhylomeDB" id="Q9X7W3"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189157" description="1-deoxy-D-xylulose-5-phosphate synthase 1">
        <location>
            <begin position="1"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="656" mass="69546" checksum="A8E5497B50425D08" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8C2</accession>
    <name>Q9X8C2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3442</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36208">
        <property type="entry name" value="T36208"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627647.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028983.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3442"/>
    <dbReference type="GeneID" id="1098879"/>
    <dbReference type="KEGG" id="sco:SCO3442"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3504"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_11_0_11"/>
    <dbReference type="InParanoid" id="Q9X8C2"/>
    <dbReference type="OMA" id="MVNPTAG"/>
    <dbReference type="PhylomeDB" id="Q9X8C2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="13031" checksum="B28E223FC4A0BBA9" modified="1999-11-01" version="1">MPAPVRPDPAKVQMYWRPGCPYCAMLRRQLRRTGLSYEPVDIWKDQSGAAYVRSVNNGNETVPTVAVAGHPLTNPSARQVLEAVQRHAPHLLPETAPADAARRWRPRWPWRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8G4</accession>
    <name>Q9X8G4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36289">
        <property type="entry name" value="T36289"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627549.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028920.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3340"/>
    <dbReference type="GeneID" id="1098777"/>
    <dbReference type="KEGG" id="sco:SCO3340"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3400"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_3_4_11"/>
    <dbReference type="InParanoid" id="Q9X8G4"/>
    <dbReference type="OMA" id="LALWWNT"/>
    <dbReference type="PhylomeDB" id="Q9X8G4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28338" checksum="F058362540463D54" modified="1999-11-01" version="1">MTTPPQADHSARAHSFNAAAAQYAANRPSYPPALFDALEELTGRPLKGSRVVDVGAGTGLATARLHERGADVIAVEPGAGMAAEFRRTLPGVPVVRGNGNALPLADHGADLLTYAQSWHWTDPTLAVPEALRVLRPGGALALWWNTDAHDVPWIADSGRRIDRHFAGLNLSAEKRNFDARFADPTGNLDFVHHEIRWSRRVPLDTHLANLGSHSVFLTDTEERATAFFAEERRHLLAVFPDGLVEETYDVHLLLAPTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8U7</accession>
    <name>Q9X8U7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">SCO3911</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36598">
        <property type="entry name" value="T36598"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628097.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975021.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3911"/>
    <dbReference type="GeneID" id="1099347"/>
    <dbReference type="KEGG" id="sco:SCO3911"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3985"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8U7"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="PhylomeDB" id="Q9X8U7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="14">
        <location>
            <begin position="225"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAB42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="491" mass="53981" checksum="6DC925F98A17C806" modified="1999-11-01" version="1">MSISEPLDDPWADSGPSDRLPASRRRTEGGRGRDEQHERGPDSGWDGGGAAFERVPPQDLDAEQSVLGGMLLSKDAIADVVEILKGHDFYKPAHETVYQAILDVYAKGEPADPITIAAELTKRGEINKVGGASYLHTLVQTVPTAANAAYYAEIVHERAVLRRLVEAGTRITQMGYAADDDVDEIVNRAQAEIYAVTEQRTSEDYLPLGDIMEGALDEIEAIGSRSGEMTGVPTGFTDFDSLTNGLHPGQMVVIAARPAMGKSTLALDFARAASIKNNLPSVIFSLEMGRNEIAMRLLSAEARVALHHMRSGTMTDDDWTRLARRMPDVSAAPLYIDDSPNLSMMEIRAKCRRLKQRNDLKLVVIDYLQLMQSGGSKRAESRQQEVSDMSRNLKLLAKELEIPVIALSQLNRGPEQRTDKKPMVSDLRESGSIEQDADMVILLHREDAYEKESPRAGEADLIVAKHRNGPTATITVAFQGHYSRFVDMAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X934</accession>
    <name>Q9X934_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3581</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB41729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36690">
        <property type="entry name" value="T36690"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627777.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975355.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3581"/>
    <dbReference type="GeneID" id="1099017"/>
    <dbReference type="KEGG" id="sco:SCO3581"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3637"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X934"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="PhylomeDB" id="Q9X934"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB41729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="154" mass="16488" checksum="91327C8A60BE8961" modified="1999-11-01" version="1">MTTLKAKLHDDLNSSIKERDELRSSTLRLTLAAITKEEVAGKEKRELSDDEVQKVIIREAKKRREAAEAFAQGGRAEQAEREKAEGEVLAAYLPKQLSDDELNAIVAQAVQEAKAAGAEGPRAMGAVMKIVNPKVAGQAEGGRVAAAVKKLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA80</accession>
    <name>Q9XA80_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hva1_TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0845</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36458">
        <property type="entry name" value="T36458"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625145.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027386.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0845"/>
    <dbReference type="GeneID" id="1096268"/>
    <dbReference type="KEGG" id="sco:SCO0845"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.837"/>
    <dbReference type="eggNOG" id="ENOG50336GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180079_1_1_11"/>
    <dbReference type="InParanoid" id="Q9XA80"/>
    <dbReference type="OMA" id="PQYQVRS"/>
    <dbReference type="PhylomeDB" id="Q9XA80"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hva1_TUDOR" evidence="2">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB48922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="88" mass="9894" checksum="EE4529EAF91778A1" modified="1999-11-01" version="1">MPKAGARRRRSTTMAKNRDDRERLKKGDKVTWSSHGSRTEGEVEKKITKRTEAAGRTVDASADDPQYQVRSDRSGRSAVHKPSALKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAA1</accession>
    <name>Q9XAA1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0824</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36437">
        <property type="entry name" value="T36437"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625124.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978035.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0824"/>
    <dbReference type="GeneID" id="1096247"/>
    <dbReference type="KEGG" id="sco:SCO0824"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.816"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9XAA1"/>
    <dbReference type="OMA" id="MCDYLLV"/>
    <dbReference type="PhylomeDB" id="Q9XAA1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB48901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="32003" checksum="6959B6634A890A1A" modified="1999-11-01" version="1">MTGPDEPAALHATDLGFRYRARGDRALRDCGFTVPRGRITALVGRNGAGKSTLLHLAGGLLNPTHGRIRVLGSAPGTAAARTRVALLTQDRPLYPRFTVADTLRMGGKLNPSWDRSVAERVVREGDIAPTARVGELSPGRRTRVALALALGKRPDLLLLDEPLADLDPVVRAEIMATLMAEAAEREVSIVMSSHVLPDLEQTCDWVLLLRAGRVELSEDADALREGHTLLTGHVDEEPALREHTVVRRRTHGRQLTALVRPRGPVGGDWHVERPGLEEILLGHLQEGAAAENGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAK9</accession>
    <name>Q9XAK9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3593</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35361">
        <property type="entry name" value="T35361"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627788.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029108.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3593"/>
    <dbReference type="GeneID" id="1099029"/>
    <dbReference type="KEGG" id="sco:SCO3593"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3649"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048411_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAK9"/>
    <dbReference type="OMA" id="GSNAIQW"/>
    <dbReference type="PhylomeDB" id="Q9XAK9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="397" mass="44064" checksum="905B07E5441C7DC6" modified="1999-11-01" version="1">MAYSEPVRTTAPTRPTVRQISAAEHLAFVRAQRSVSFLQTPAWGRVKTEWRSESLGWFDGGRLVGAGLVLHRPVPRLERFTLAYLPEGPVIDWTGDIDAWLDPLAAYLKARGAFAIRLGPPVCTDVWSADEIKEGIADPGTRRLTGLPTRWTDPVGAHVTDRLRDAGWLPQSPEDGFGVGHPQFKYEVPLAGRTEDDLLKGMNQLWRRNIRKAAKEGVEVTLGDATPGYAAAGEAAVADDVKAFHDLYVHTAERDRFTPRPLRYFATMFAVLGAEDPERIKLYLARHRGDLVAATVMVRVGTHAVYAYGASSTGKREVRGSNACQWAMIRDALAADCDVYDLRGITPTLDADDPHVGLIKFKVGTGGRAVRYVGEWDLPLRPLVYRTFDLYMKRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN2</accession>
    <name>Q9ZBN2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6177</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35484">
        <property type="entry name" value="T35484"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630281.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030713.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6177"/>
    <dbReference type="GeneID" id="1101618"/>
    <dbReference type="KEGG" id="sco:SCO6177"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6287"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123373_1_0_11"/>
    <dbReference type="OMA" id="WRRVTDW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA22511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="16296" checksum="548A4B87CE79479C" modified="1999-05-01" version="1">MAVFSLERTVPLTPDEAWRRLTRWERHGDTVPLTRVTARPPGPTRPGTLVVARTGAGPLAFDDTMEVTVWRPPREDAPGRCRLEKRGRVVGGWAEIEVGAGPGGRARVVWREELDVRLLPSFLDGLLARSGRHVFGRTVTHLLRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBP9</accession>
    <name>Q9ZBP9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="9" type="ordered locus">SCO5580</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35664">
        <property type="entry name" value="T35664"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030316.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5580"/>
    <dbReference type="GeneID" id="1101021"/>
    <dbReference type="KEGG" id="sco:SCO5580"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5671"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_1_3_11"/>
    <dbReference type="InParanoid" id="Q9ZBP9"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="PhylomeDB" id="Q9ZBP9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="219"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA22423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="43650" checksum="61C73D49FDDEA039" modified="1999-05-01" version="1">MPGVTHTGPVMEIVILAVVIAVVVIGALGGLVVGSRRKKQLPEPPPATPDITAPPAEPHVGDEAETPRDETRRTIEEVDLPDGGTATVEEPPVVEELEIPQIEVPEPTAGRLVRLRARLSRSQNALGKGLLTLLSREHLDDDTWEEIEDTLLTADVGVQPTQELVERLRERVKVLGTRTPEELRTLLREELITLVGPDMDREVKTEPATSKPGIVMVVGVNGTGKTTTTGKLARVLVADGRSVVLGAADTFRAAAADQLQTWGERVGAHTVRGPEGGDPASVAFDAVKEGKEMGSDVVLIDTAGRLHTKTGLMDELGKVKRVVEKHAPLDEVLLVLDATTGQNGLIQARVFAEVVNITGIVLTKLDGTAKGGIVVAVQRELGVPVKLIGLGEGADDLAPFEPAAFVDALIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ2</accession>
    <name>Q9ZBQ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">smc</name>
        <name evidence="9" type="ordered locus">SCO5577</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35661">
        <property type="entry name" value="T35661"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030315.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5577"/>
    <dbReference type="GeneID" id="1101018"/>
    <dbReference type="KEGG" id="sco:SCO5577"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5667"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ2"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="PhylomeDB" id="Q9ZBQ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177079" description="Chromosome partition protein Smc" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="8">
        <location>
            <begin position="512"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="731"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA22420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1186" mass="128724" checksum="CB11027815373E99" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ5</accession>
    <name>Q9ZBQ5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5574</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35658">
        <property type="entry name" value="T35658"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030313.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5574"/>
    <dbReference type="GeneID" id="1101015"/>
    <dbReference type="KEGG" id="sco:SCO5574"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5663"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ5"/>
    <dbReference type="OMA" id="CPSRGTL"/>
    <dbReference type="PhylomeDB" id="Q9ZBQ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="15848" checksum="60BF4373CBC405B4" modified="1999-05-01" version="1">MLAYAGGMSTTQERTAEQDLPFDVFSRACPSRGTLEHVTGRWGALTLGALYEGSFRFNELRRRVDGVSEKMLAQTLHALERDGLVHREAQPTNPPRVDYELTALGHEVAGRLLALIECVEGRMDEVLASRERYDERRMPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBZ8</accession>
    <name>Q9ZBZ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6515</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34745">
        <property type="entry name" value="T34745"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630597.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030978.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6515"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="GeneID" id="1101954"/>
    <dbReference type="KEGG" id="sco:SCO6515"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6618"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_11"/>
    <dbReference type="InParanoid" id="Q9ZBZ8"/>
    <dbReference type="OMA" id="IGKYGVP"/>
    <dbReference type="PhylomeDB" id="Q9ZBZ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="19493" checksum="EBB138E52D2E251D" modified="1999-05-01" version="1">MRIAFLTAPEGVEQVELTEPWRAAKEAGHDPVLVSTQSGEIQGFDHLDKADTFPVDEVVGEISADAFGGLVLPGGVANPDFLRMDEKAVAFVKDFFTQGRPVAAICHAPWTLVEADVVRGRTMTSWPSLRTDLRNAGATWVDEQVQVCDAGDNVLVTSRKPDDLEAFCETYLAQFAKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZC05</accession>
    <name>Q9ZC05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gas vesicle synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6508</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34738">
        <property type="entry name" value="T34738"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630590.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972470.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6508"/>
    <dbReference type="GeneID" id="1101947"/>
    <dbReference type="KEGG" id="sco:SCO6508"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6610"/>
    <dbReference type="eggNOG" id="ENOG50330IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150705_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZC05"/>
    <dbReference type="OMA" id="NDFARIM"/>
    <dbReference type="PhylomeDB" id="Q9ZC05"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA22045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="11489" checksum="E496F7A412D42EE3" modified="1999-05-01" version="1">MSEPAEPRKRRLDLEPDTVERDLIKLVLTVVELLRQLMERQALRRVDEGDLSEDQEERIGLTLMLLDDRMTELRDRYGLRPEDLNLDLGPLGPLLPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O50508</accession>
    <name>O50508_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5834</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35870">
        <property type="entry name" value="T35870"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629957.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973187.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5834"/>
    <dbReference type="GeneID" id="1101276"/>
    <dbReference type="KEGG" id="sco:SCO5834"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5931"/>
    <dbReference type="eggNOG" id="ENOG5033NU0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097938_0_0_11"/>
    <dbReference type="OMA" id="TDEWWVV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045728">
        <property type="entry name" value="DUF6082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19560">
        <property type="entry name" value="DUF6082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA15791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="27749" checksum="71B8CF78D0A7FF89" modified="1998-06-01" version="1">MRGADVFQGAGPCDPRFPPCASSPPPRRSAPLGTLEAAAPSIARRSPSADPHSTTGGRSPDSGVDMVTRKNATGRFGSAAAGMLLATAGISLAARRRRREAARMHERLLELEELAIRRQSLAHQQRMHWELLTRAIDDPSLAEVIDTYDKSIPAERRRQFFYANAWYVNLYHVHRAGLLDQEGLQGRLREFFQSPVFREYWEATRNMRAALDQNSDEARLGLVVDALAKDFEDTDTDEWWVVGTPPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O54131</accession>
    <name>O54131_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5865</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34817">
        <property type="entry name" value="T34817"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629987.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030505.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5865"/>
    <dbReference type="GeneID" id="1101307"/>
    <dbReference type="KEGG" id="sco:SCO5865"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5964"/>
    <dbReference type="eggNOG" id="ENOG5032TUY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070587_1_0_11"/>
    <dbReference type="OMA" id="NLMPFMV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="317" mass="33841" checksum="4AC56BD63D82DB16" modified="1998-06-01" version="1">MTGSTPPWKRRFSRRGADQGPSDGPYSARDDERGPTDTGKAPLEPVADRSDLPATTRPPAPAARRRAAAFREKAGQGVRNGGARARAALGHLADRIIDLAPRVPVRDLAALRRQFPGLGPEEIADRLVAGAAKGTATVGAGIGAAAMLPVPPAMPTELAAEITGVAAIELKLIAELHEVYGVRPPGGLAQRSTAYLNSWSDERGVDVSKPSTLGSAMNSHMKRQLRQQIMKRMVRDLPNLMPFMVGAAVGAVMNRRDTRKLAARIRTDLRKNQVAWSALGDLPALERPQDALDMGEITKGIGPGRPGRGENFGKDER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-04-07" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O54174</accession>
    <name>O54174_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5945</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35710">
        <property type="entry name" value="T35710"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630062.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973077.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5945"/>
    <dbReference type="MEROPS" id="T03.014"/>
    <dbReference type="GeneID" id="1101387"/>
    <dbReference type="KEGG" id="sco:SCO5945"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6041"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_3_2_11"/>
    <dbReference type="InParanoid" id="O54174"/>
    <dbReference type="OMA" id="SFWPRTW"/>
    <dbReference type="PhylomeDB" id="O54174"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="606" mass="63967" checksum="21AF7B5FD7F0A1AB" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O54175</accession>
    <name>O54175_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5946</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35711">
        <property type="entry name" value="T35711"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630063.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030554.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5946"/>
    <dbReference type="GeneID" id="1101388"/>
    <dbReference type="KEGG" id="sco:SCO5946"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6042"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_2_0_11"/>
    <dbReference type="InParanoid" id="O54175"/>
    <dbReference type="OMA" id="HIFTANM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA16203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="24579" checksum="FDAFC41A51046806" modified="1998-06-01" version="1">MNVRRRVTQPGLMLALTFATGVVDAVGYLRLDQVFAGNMTGNVVILGMAATGGGTGLPVLGPVVALASFLAGAATAGRVLRTAAPGWSSRCGALLGGVGLVLTATALGPALVGADTSGARAGMASSLALAMGAQAATARHLAVRDVTTVVVTSTLTGLAADSRLGAARGRGALRRTAAVALIVAGAAAGALLCQVHEGLAVAAAACVVLAVTALGSRAAPATTGAPSTAPPTAPATASSTAPSTASSTAPSTVLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O54183</accession>
    <name>O54183_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitinase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO5954</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35719">
        <property type="entry name" value="T35719"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630071.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030560.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5954"/>
    <dbReference type="CAZy" id="CBM2">
        <property type="family name" value="Carbohydrate-Binding Module Family 2"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="1101396"/>
    <dbReference type="KEGG" id="sco:SCO5954"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6051"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_4_11"/>
    <dbReference type="InParanoid" id="O54183"/>
    <dbReference type="OMA" id="WEWPGAE"/>
    <dbReference type="PhylomeDB" id="O54183"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004159200" evidence="6">
        <location>
            <begin position="34"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="152"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="247"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="340"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA16211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="765" mass="80351" checksum="DCA0FD813F1CCD53" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O69812</accession>
    <name>O69812_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6418</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28688">
        <property type="entry name" value="T28688"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630504.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030903.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101857"/>
    <dbReference type="KEGG" id="sco:SCO6418"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6518"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026292_0_0_11"/>
    <dbReference type="InParanoid" id="O69812"/>
    <dbReference type="OMA" id="ANNIMAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174846" evidence="1">
        <location>
            <begin position="31"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="193"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="328"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA18905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="542" mass="54004" checksum="D43533846FCDE5CD" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O86534</accession>
    <name>LEUC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuC</name>
        <name type="ordered locus">SCO5553</name>
        <name type="ORF">SC1C2.34</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29083">
        <property type="entry name" value="T29083"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973442.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86534"/>
    <dbReference type="SMR" id="O86534"/>
    <dbReference type="STRING" id="100226.SCO5553"/>
    <dbReference type="GeneID" id="1100993"/>
    <dbReference type="KEGG" id="sco:SCO5553"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5641"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_11"/>
    <dbReference type="InParanoid" id="O86534"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="PhylomeDB" id="O86534"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000076826" description="3-isopropylmalate dehydratase large subunit">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="476" mass="50480" checksum="89C3921EFB125109" modified="1998-11-01" version="1">MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLRKSGRPVRRLDLTIATEDHNTPTLDIDKPIADPVSRAQLETLRKNCADFGVRLHPLGDVEQGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPLARPKTMAITVDGELPEGVTAKDLILAIIARIGTGGGQGYILEYRGEAIEKLSMEARMTICNMSIEAGARAGMIAPDETTFAYLQGRPHAPEGADWDAAVEYWKTLRTDDDAEFDAEVVIEAAELAPFVTWGTNPGQGAPLSAAVPDPASYEDASERFAAEKALEYMGLEAGQPLRSIQVDTVFVGSCTNGRIEDLRAAAEIVRDRKVADGVRMLVVPGSARVGLQAVSEGLDVVFKEAGAEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGHLASPADLSAADVPTPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>O86645</accession>
    <name>O86645_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T10921">
        <property type="entry name" value="T10921"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629852.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030418.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5726"/>
    <dbReference type="GeneID" id="1101165"/>
    <dbReference type="KEGG" id="sco:SCO5726"/>
    <dbReference type="eggNOG" id="ENOG5031Y8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1659708_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17389" checksum="8AA78EA9FDEB7539" modified="1998-11-01" version="1">MDEVSPQEAFDAFIHARVYCERPEDSGFLTVVAPNPPAVDAPPRSRILDLVTTTDTAPAGPRVHVAGTARAVHGRRRVVLDNGRRPPRSAATGTRRMAGPGRRARRTACLEGQAQFEDEHPVTSFLEGHGIAEESIEFRGRLEPVDRDGQDNGTEQTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O86684</accession>
    <name>O86684_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6638</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35047">
        <property type="entry name" value="T35047"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630714.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031064.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6638"/>
    <dbReference type="GeneID" id="1102077"/>
    <dbReference type="KEGG" id="sco:SCO6638"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6743"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021082_0_0_11"/>
    <dbReference type="InParanoid" id="O86684"/>
    <dbReference type="OMA" id="MARWFFM"/>
    <dbReference type="PhylomeDB" id="O86684"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="605" mass="67770" checksum="3956D78E8CEB556E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O87595</accession>
    <accession>Q7AKQ3</accession>
    <name>O87595_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5448" last="5453">
            <title>The 20S proteasome of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Nagy I."/>
                <person name="Tamura T."/>
                <person name="Vanderleyden J."/>
                <person name="Baumeister W."/>
                <person name="De Mot R."/>
            </authorList>
            <dbReference type="PubMed" id="9765579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="1999-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="De Mot R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF086832">
        <property type="protein sequence ID" value="AAC64283.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625922.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977179.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1647"/>
    <dbReference type="GeneID" id="1097078"/>
    <dbReference type="KEGG" id="sco:SCO1647"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1661"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040524_1_0_11"/>
    <dbReference type="OMA" id="YFRGRCL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC64283.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="497" mass="56321" checksum="2512DE318363F438" modified="1999-11-01" version="2">MGIETEYGISVPGHPNANAMLTSSQIVNAYAAAMHRARRARWDFEEENPLRDARGFDLAREAADNSQLTDEDIGLANVILTNGARLYVDHAHPEYSAPEVTNPRDAVLWDKAGERIMAEAAERAAQLPGAQPIHLYKNNTDNKGASYGTHENYLMKRETAFSDIVRHLTPFFVSRQVFTGAGRVGIGQDGHEHGFQLSQRADYFEVEVGLETTLKRPIINTRDEPHADAEKWRRLHVIIGDANLSEISTYLKLGTTALVLSMIEDGFIAVDLAVDQPVRTLHQVSHDPTLKHLVTLRSGRTLTAVQLQMEYYELARKYVEERYGADADDQTKDVLGRWEDTLNRLENDPMSLAGELDWVAKRELMEGYRRRDNVDWDAARLHLVDLQYADVRPDKGLYNRLVDRGRIKRLLDENEVERARTKPPEDTRAYFRGRCLEQYADDVAAASWDSVIFDLPGRDSLQRVPTLEPLRGTRNHVKELLDRCRTAEDLVRVLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O88051</accession>
    <name>O88051_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1591</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36826">
        <property type="entry name" value="T36826"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625867.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977233.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1591"/>
    <dbReference type="GeneID" id="1097022"/>
    <dbReference type="KEGG" id="sco:SCO1591"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1603"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="InParanoid" id="O88051"/>
    <dbReference type="OMA" id="FYDYSES"/>
    <dbReference type="PhylomeDB" id="O88051"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="24"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="32565" checksum="29F0F08BB56B9F2E" modified="1998-11-01" version="1">MPATSRGVSERDDVTGISGDIARVGVVGCGQMGAGIAEVCARSGLEVMVAETTGEALEIGRTRLYNSLAKAAERGKMTEEERDATQARLSFTTDLGEFADRDLVIEAVVENEQVKTEIFQVLDQVVTRPDAILASNTSSIPLVKLAVATSRPDHVIGIHFFNPAPVQQLVELIPALTTSEGTLSRAQLFTEKVLGKHAIRAQDRSGFVVNALLIPYLLSAIRMFESGIASREDIDNGMEMGCAHPMGPLKLADLIGLDTVASVAYSMYEEYKEPLYAAPPLLQRMVDAGRLGRKSGSGFYAYG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>P0A4P1</accession>
    <accession>O69882</accession>
    <name>TRMD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber>2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">trmD</name>
        <name type="ordered locus">SCO5594</name>
        <name type="ORF">SC2E1.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34779">
        <property type="entry name" value="T34779"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629728.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973399.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A4P1"/>
    <dbReference type="SMR" id="P0A4P1"/>
    <dbReference type="STRING" id="100226.SCO5594"/>
    <dbReference type="PRIDE" id="P0A4P1"/>
    <dbReference type="GeneID" id="1101035"/>
    <dbReference type="KEGG" id="sco:SCO5594"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5686"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_0_11"/>
    <dbReference type="InParanoid" id="P0A4P1"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="PhylomeDB" id="P0A4P1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060477" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="277" mass="30828" checksum="61CB740770A3A4C8" modified="2005-03-15" version="1">MRLDVVTIFPEYLEPLNVSLVGKARARGQLGVHVHDLRDWTYDRHNTVDDTPYGGGPGMVMKTEPWGDALDSVLADGYETGCGEPALVVPTPSGRPFTQELAVHLSERPWLIFTPARYEGIDRRVVDEYATRMPVYEVSIGDYVLAGGEAAVLVVTEAVARLLPGVLGNAESHRDDSFAPGAMANLLEGPVHTKPPQWRGRGIPDVLLSGHHGKIARWRRDEALRRTTANRPDLIERCDPAAFDKKDREMLSILGWQPDPDGEPYGRFWRRTPGMEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>P53433</accession>
    <name>PTPA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Low molecular weight protein-tyrosine-phosphatase</fullName>
            <shortName>PTPase</shortName>
            <ecNumber>3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Small, acidic phosphotyrosine protein phosphatase</fullName>
            <shortName>PY protein phosphatase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ptpA</name>
        <name type="ordered locus">SCO3921</name>
        <name type="ORF">SCQ11.04c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="136" last="142">
            <title>Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Li Y."/>
                <person name="Strohl W.R."/>
            </authorList>
            <dbReference type="PubMed" id="8550407"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / 1147</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. May be involved in the regulation of sulfur amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48"/>
    <dbReference type="EMBL" id="U37580">
        <property type="protein sequence ID" value="AAC43614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37174">
        <property type="entry name" value="T37174"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628106.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975011.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P53433"/>
    <dbReference type="SMR" id="P53433"/>
    <dbReference type="STRING" id="100226.SCO3921"/>
    <dbReference type="GeneID" id="1099357"/>
    <dbReference type="KEGG" id="sco:SCO3921"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3995"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_1_11"/>
    <dbReference type="InParanoid" id="P53433"/>
    <dbReference type="OMA" id="TGSWHVG"/>
    <dbReference type="PhylomeDB" id="P53433"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000046569" description="Low molecular weight protein-tyrosine-phosphatase">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P11064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="164" mass="17690" checksum="56A4AC5D644771F9" modified="1996-10-01" version="1">MTYRVCFVCTGNICRSPMAEAVFRARVEDAGLGHLVEADSAGTGGWHEGEGADPRTEAVLADHGYGLDHAARQFQQSWFSRLDLVVALDAGHLRALRRLAPTERDAAKVRLLRSYDPAVAGGDLDVPDPYYGGRDGFEECLEMVEAASTGLLAAVREQVEGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK7</accession>
    <name>Q8CJK7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7198</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733726.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031502.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7198"/>
    <dbReference type="GeneID" id="1102636"/>
    <dbReference type="KEGG" id="sco:SCO7198"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7298"/>
    <dbReference type="HOGENOM" id="CLU_2060103_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="15333" checksum="942CAD6EE69E7881" modified="2003-03-01" version="1">MHREQNDCLGGGGDRELTDEYLVGDEQFLTEAASTGRRPTRDERDSRRALGERAADAGHGLRLLVSDHLAAAPVIWPRFSSPTNSALAALHRAVDAFAEGYEGAQRLAVRHQETARRGSHRNAFDRVRLRAYGRLPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL3</accession>
    <name>Q8CJL3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative binding protein dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7012</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733720.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031378.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7012"/>
    <dbReference type="GeneID" id="1102450"/>
    <dbReference type="KEGG" id="sco:SCO7012"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7114"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="InParanoid" id="Q8CJL3"/>
    <dbReference type="OMA" id="IIATMQV"/>
    <dbReference type="PhylomeDB" id="Q8CJL3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="35048" checksum="2D7116F6E0F9685F" modified="2003-03-01" version="1">MSAPSLTPSKAARARHAQPPVDGPPQHGGAFGRSLKRNLTAHGFLIGAVLCFAFFSWYPMVREFFLAFQKTDQGEVSWVGLENLETVFNDPAFWQAWRNTALFTVLALVLGFAVPFVVAIVINELRHGKGYLRLLVYLPVMLPPVASVLLFKYLYDPGYGMLNEVFGFFGLPEQQWLQDPDLSMLSVVIASTWMNMGGAALIYLAALQGIPGELYEAAELDGAGLLRKIWHVTIPQTRLILSLMLLMQIIATMQVFVEPFLLTGGAGPEGSTTTVVYLIYQYAFNFNNYGAAAALGLLLLVLLAGFSAAYVKLSRAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX1</accession>
    <name>Q8CJX1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3284</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAD55311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36104">
        <property type="entry name" value="T36104"/>
    </dbReference>
    <dbReference type="PIR" id="T36244">
        <property type="entry name" value="T36244"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733598.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028885.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3284"/>
    <dbReference type="GeneID" id="1098718"/>
    <dbReference type="KEGG" id="sco:SCO3284"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3344"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_3_11"/>
    <dbReference type="InParanoid" id="Q8CJX1"/>
    <dbReference type="OMA" id="YAVYDPF"/>
    <dbReference type="PhylomeDB" id="Q8CJX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="711" mass="75577" checksum="628310CCAFE9B61E" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK41</accession>
    <name>Q8CK41_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0974</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAD55451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733519.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027483.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CK41"/>
    <dbReference type="STRING" id="100226.SCO0974"/>
    <dbReference type="GeneID" id="1096397"/>
    <dbReference type="KEGG" id="sco:SCO0974"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.971"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_12_1_11"/>
    <dbReference type="InParanoid" id="Q8CK41"/>
    <dbReference type="OMA" id="DGRYSQY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176139" evidence="3">
        <location>
            <begin position="42"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="439" mass="46934" checksum="C8B8202150ADB990" modified="2003-03-01" version="1">MAVRGRHRRYQPNRINRASLTVTAGGAGLALPLVGTGTAHAADAATWDKVAACESTDDWDINTGNGYYGGLQFTQSTWEAFGGTRYAPRADLATREQQIAGAEKVLDTQGPGAWPVCSERAGLTRGGDPPDIRPAGSAAPAQKTSDSVKDVQPQTTPQSRAGKARMYTVVTGDTLSGIADTHEVRGGWQRLYEANRSAIGSDPDLILPGQRLSLRGQGTTRAPGAEAGRRQDEQQPQRDKQRQKQQDKQQKQHRKEQKQEQKQEPKQEPKEQKRQEQKQQEQRKAPKESSSDSGKAKAAGKATAHRAVVAPVDAATGTPYHQAGSSWSKGYHTGVDFPVPTGTSVKSVADGRVVSAGWGGSYGYQVVVRHGDGRYSQYAHLSAISVKSGQSVGVGQRLGRSGSTGNVTGPHLHFEVRTGPGFGSDVDPVAYLRAGGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IU2</accession>
    <name>Q93IU2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BldKB, putative ABC transport system lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5113</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629263.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973864.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5113"/>
    <dbReference type="TCDB" id="3.A.1.5.36">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100554"/>
    <dbReference type="KEGG" id="sco:SCO5113"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5196"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_9_0_11"/>
    <dbReference type="OMA" id="GWGQDWP"/>
    <dbReference type="PhylomeDB" id="Q93IU2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042884">
        <property type="term" value="P:microcin transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176567" evidence="2">
        <location>
            <begin position="36"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="120"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="600" mass="65533" checksum="9CAD7DF4B5D95E95" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IV9</accession>
    <name>Q93IV9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625597.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027714.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1311"/>
    <dbReference type="GeneID" id="1096734"/>
    <dbReference type="KEGG" id="sco:SCO1311"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1314"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104555_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IV9"/>
    <dbReference type="OMA" id="ETGMEYG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="52"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="19365" checksum="C58DD5D29550FC96" modified="2001-12-01" version="1">MHAPIGNFDSAAPARDRLDALTRPVADAVRHWSGTVPADQILYADTEPDWADTATFVEHYGRELLEQSANCVVVTGKRGGGTTLAACVVLSTTRVDVNGVVRRRLGARKASFAPMDTATGETGMEYGGITPVGLPAGWPVLVDSAVVDLPYVLVGSGRRRGKLLVPGKAFAELPGAEVLEGLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IX7</accession>
    <name>Q93IX7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1293</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625579.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027701.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1293"/>
    <dbReference type="GeneID" id="1096716"/>
    <dbReference type="KEGG" id="sco:SCO1293"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1294"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050048_0_0_11"/>
    <dbReference type="OMA" id="GHLLWDG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="287"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="452" mass="47342" checksum="1EBAFA60318FCD21" modified="2001-12-01" version="1">MSDVTDAVARLVDHGPTVPALVLASLAALIATAGFHTRWSRRHGQAPPADDTGARPPTAERPAGTGPAGSEPGGSEPCGSGAGGESALWRMRTTVRDAPGSLAVLCAALADRRIDILSLQTHPLTEGTVDEFLLRAPGELSAAELAEVVTTAGGARTWTERADAHDLVDAPTRVLGLAARTALDAAELPLALRQLLGRCTIRSLPAPADDGAGARAAAAVPPEGALEDTVLRLRAPEGGVISVERPHLPFTPAEFARARALVELDARLGPRVPRGRDVLTLPEGSDITVRRADTRDVPAAKAMHERCSARTLGMRYHGPVGDADRYLNHLLSPRFGRTLAVQTASGRLVGLGHLLWDGDETEVALLVEDGWQRRGIGGELLARLVAMAADAGCESVYAITQASNTGMVAAMRGLSLPLDYQIEEGTLVVTARLDPAAQAAARLPQAERIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J33</accession>
    <name>Q93J33_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5926 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3974</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628157.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974969.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3974"/>
    <dbReference type="GeneID" id="1099410"/>
    <dbReference type="KEGG" id="sco:SCO3974"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4047"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075039_0_0_11"/>
    <dbReference type="OMA" id="RYKACHG"/>
    <dbReference type="PhylomeDB" id="Q93J33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="2">
        <location>
            <begin position="56"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="34519" checksum="CEA7B948435D5FDF" modified="2001-12-01" version="1">MAKKRPQTKAKRPQLDDAEVPVVGAREPCPCGSGRRYKACHGRTAAQATTALVQRPFEGLAGECDWVALRELVPAATVELTLRDGLPEGVPSVTLATVLPMAWPALRRDDGSVLLGLQNDTASGDISRDLADTLARALTADPGTPVQGRRAPADGPRLQDLLAPEGAFEPEVHSGFEFWVPDPENATPDVTASLERANAAAIPTVRLQGVDAAYWCETPDKNHLRWVMPHEEERLLDALARLHAAGRSSLGEGTRLVGSFRAHGLTVPVWDLPSEVTAQDIEKPAAEFAERLAEALATDAPLTHDERRARGGLTNRQVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J55</accession>
    <name>Q93J55_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3047</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627268.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028735.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3047"/>
    <dbReference type="GeneID" id="1098480"/>
    <dbReference type="KEGG" id="sco:SCO3047"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3107"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_3_11"/>
    <dbReference type="InParanoid" id="Q93J55"/>
    <dbReference type="OMA" id="PCHCTDT"/>
    <dbReference type="PhylomeDB" id="Q93J55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
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    </dbReference>
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        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="147"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="409"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="524" mass="56635" checksum="9672DF36920722DB" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JE6</accession>
    <name>Q93JE6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5981</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630097.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973040.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5981"/>
    <dbReference type="GeneID" id="1101423"/>
    <dbReference type="KEGG" id="sco:SCO5981"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6080"/>
    <dbReference type="eggNOG" id="COG1020">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072287_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JE6"/>
    <dbReference type="OMA" id="DLEHLLW"/>
    <dbReference type="PhylomeDB" id="Q93JE6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="34181" checksum="A0408E2EB0DFF666" modified="2001-12-01" version="1">MSLARNLNRALTVTTGLQVRRAPRAANGSPRGRQGGKSAAAQPAARRAAPYRCPSAGELPTDRLLRRPVFIISSIRSGSTLLRMMMGAHPRLHAPHELHVGKVEVACTTWHSERAMGELGLLRGDLEHLLWDRVLHRELIRSGKDFVVEKTPANAYMYQRLKDCWPDARFVFLLRHPESIARSWHESDPVKRPHDTAVTDVLRYMTAVQEARSADADGFTVRYEDITGDPEREMRRLCAYLGVDYTPRMLNYGKKGNAELVRGLGDWRENIRTGTVQPGRELPGKDEVPERLRPMCAAWGYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JE9</accession>
    <name>Q93JE9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5978</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630094.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973043.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5978"/>
    <dbReference type="GeneID" id="1101420"/>
    <dbReference type="KEGG" id="sco:SCO5978"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6077"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_18_0_11"/>
    <dbReference type="InParanoid" id="Q93JE9"/>
    <dbReference type="OMA" id="GKAVWFR"/>
    <dbReference type="PhylomeDB" id="Q93JE9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="17150" checksum="27182FCF821F2CA1" modified="2001-12-01" version="1">MKAGQDSPAPRNGPAVHDHFPAPASWRIALPHSAAAVPVARALVRNALAELEHTADGDTAELLTAELVANAVEHTPAGPTAIELVVELMPTGCQVEVHDPDPSPPADLTRPDVEPPDPWREDGRGLLLIRALSSSCGHRPTRSGKAVWFRLPAVPAQRRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RV2</accession>
    <name>Q93RV2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1874</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626141.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028023.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1874"/>
    <dbReference type="GeneID" id="1097308"/>
    <dbReference type="KEGG" id="sco:SCO1874"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1899"/>
    <dbReference type="HOGENOM" id="CLU_2755988_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC38809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="70" mass="7430" checksum="7DEC52C7F29AE54B" modified="2001-12-01" version="1">MGAWTHDSDVRRHPAHRRLRPNARGEVLRPMASGLTDAKIAGRPGAGPAAAKMHVASVPARTGARDRTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RY0</accession>
    <name>Q93RY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dihydropicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630390.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030799.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6292"/>
    <dbReference type="BindingDB" id="Q93RY0"/>
    <dbReference type="ChEMBL" id="CHEMBL3430"/>
    <dbReference type="GeneID" id="1101733"/>
    <dbReference type="KEGG" id="sco:SCO6292"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6407"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_0_11"/>
    <dbReference type="InParanoid" id="Q93RY0"/>
    <dbReference type="OMA" id="FLECGKF"/>
    <dbReference type="PhylomeDB" id="Q93RY0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="32154" checksum="331D6C2F940B78A9" modified="2001-12-01" version="1">MSETRKPWHGVIVATSLPFDDDLSVDFGAYGESVAHLAAQGMHGVAPNGSLGEYQTLTYEERDRVVETAVANAPEGFTVMPGVGAYGGREAERHARFAKDAGCQAVMCLPPNAYRADDRAVLQHFERVASVGLPVTAYNNPIDTKVDLRPDLLAKLHAEGYIVGVKEFSGDVRRCYEISELAPGLDLMIGTDDTVLEVALAGAKGWVAGYPQVFPRACLALYEASVRGDLEAALPLYRQLHPVLRWDSKTEFVQAIKLGQELTGRRGGPCRPPRQPLAPETEAVVRAATQALVDAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD95</accession>
    <name>Q9AD95_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1672</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625947.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027910.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1672"/>
    <dbReference type="GeneID" id="1097103"/>
    <dbReference type="KEGG" id="sco:SCO1672"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1689"/>
    <dbReference type="eggNOG" id="ENOG50336AB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184516_0_0_11"/>
    <dbReference type="OMA" id="ASRHKEF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="29509" checksum="B7F4A95D0B1A7765" modified="2001-06-01" version="1">MSDAAQPTAAEVRAAAEAVKTALDRHLAAVERRSGEEDPAVYDAFNELAAAAEAYDELLYDRYDEVTPFEIPGEDTLPPYTGPEEPSALSVLIRRDYAVAEPQRLMAQARRVEAADEEAPDVEASGTVHGALGLLFGEFEPDEIASRHKEFGLEEGDSTLWVTAADESADPGEWLQAPFEEVDPERVVCRFDVSTVFDEEFDDDIEDEEDIEDIEDDGDRDDEDGDADLTELDGDLDTDLDTDLDTDLDTDLDEDEDDEPARLEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADD2</accession>
    <name>Q9ADD2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629475.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030184.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5335"/>
    <dbReference type="GeneID" id="1100775"/>
    <dbReference type="KEGG" id="sco:SCO5335"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5417"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179988_0_0_11"/>
    <dbReference type="OMA" id="YEREDSP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="87" mass="9862" checksum="E75CA055E41192CD" modified="2001-06-01" version="1">MYEAEQRGLSTELAVYEREDSPVLDALIFADMTTGPAGQSFDFDTRIDEILVRYEPGSEVHNAISKARPYLQGAVERTRDRMAHQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADG6</accession>
    <name>Q9ADG6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6097</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630205.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972823.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6097"/>
    <dbReference type="GeneID" id="1101538"/>
    <dbReference type="KEGG" id="sco:SCO6097"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6200"/>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_5_2_11"/>
    <dbReference type="InParanoid" id="Q9ADG6"/>
    <dbReference type="OMA" id="DWYGGPT"/>
    <dbReference type="PhylomeDB" id="Q9ADG6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="451" mass="48420" checksum="4A52F6F2BBF75D05" modified="2001-06-01" version="1">MTSTTEPVEPLSVWQLSETTLLRFATAGSVDDGKSTLVGRLLHDSKSVLTDQLEAVERASASRGQDVPDLALLTDGLRAEREQGITIDVAYRYFATPRRRFILADTPGHVQYTRNMVTGASTAELTVILVDARNGVVEQTRRHAAIAALLRVPHVVLAVNKMDLVDYQESVFAAIAEEFTAYATELGVPEVTAIPISALEGDNVVEASAVMDWYGGPTVLEHLETVPVSHDLAHCHARLPVQYVIRPQTAEHPDYRGYAGQIAAGTFRVGDEVTVLPSGRTSKVSAIDVLGEPVDAAWTPQSVTLLLEDDIDVSRGDLIVPSEDAPATSQDVEATVCHVADAPLTVGHRVLLKHGTRTVKAIVKDIPARLTLDDLSLHPHPGQLVANDIGRVKVRTAEPLPADSYADSRRTGSFILIDPSDGTTLTAGMVGESFAAPEPVKDAADADGWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK66</accession>
    <name>Q9AK66_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4051</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628233.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974912.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4051"/>
    <dbReference type="GeneID" id="1099487"/>
    <dbReference type="KEGG" id="sco:SCO4051"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4113"/>
    <dbReference type="eggNOG" id="COG3542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088365_0_3_11"/>
    <dbReference type="InParanoid" id="Q9AK66"/>
    <dbReference type="OMA" id="ERSHWHR"/>
    <dbReference type="PhylomeDB" id="Q9AK66"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="11"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="165" mass="17391" checksum="F4858497A641CFEC" modified="2001-06-01" version="1">MTPAPTPTAEDLIAHYALEPIPREGGLFRRTWAGPGRPDGRPAGSAIVALLTARPGDFSALHRLPADEVWHFYLGDPLELLLLAPDGSARTAVLGPDVLGGQHVQYTVPAGTWMGGRVGAGGAWSLFGCTMAPGFTYGDYEHGDAADLTARYPAEAARIVSLCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWR9</accession>
    <name>Q9EWR9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetracycline resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0783</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027352.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0783"/>
    <dbReference type="GeneID" id="1096206"/>
    <dbReference type="KEGG" id="sco:SCO0783"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.775"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_2_11"/>
    <dbReference type="OMA" id="ESYVNNE"/>
    <dbReference type="PhylomeDB" id="Q9EWR9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045044">
        <property type="entry name" value="EFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="PTHR43636"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="635" mass="66885" checksum="FD8DEBC2BF2310FF" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2L7</accession>
    <name>Q9F2L7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO3764</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627954.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975178.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3764"/>
    <dbReference type="GeneID" id="1099200"/>
    <dbReference type="KEGG" id="sco:SCO3764"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3823"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F2L7"/>
    <dbReference type="OMA" id="HMLIGEM"/>
    <dbReference type="PhylomeDB" id="Q9F2L7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC10302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="36493" checksum="28B6EA1B2CC49C79" modified="2001-03-01" version="1">MTVVQLFVGALTLLTNAFFVGAEFAMISVRRSQIEPRAKTGDKRARMTLWGLQHISQMMATAQLGITVSSLVLGAVAEPAIAHLMEPVFEAVHMPHALVHPVAFAIALTLATYLHMLIGEMIPKNIALAAPATTALLLGPPLVALTRALKPVVFGINAFANTLLKLLRVEPKDEVEAVFTDDQLARMVVDASEAGLLTPADGERLRDALELGTRPVGEILVPAQKMRTVPHTVTPAQLERMAADAGYSRFPVTGPGGTVLGYLHIKDTLGLTDRESPFPRTALHRVTRVRIDTPLDDTLTALRTEDSHLAAVTGETGSVLGFVTMEDVLTELVGPTTPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2M1</accession>
    <name>Q9F2M1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3760</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627950.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029218.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3760"/>
    <dbReference type="ESTHER" id="strco-q9f2m1">
        <property type="family name" value="Duf_1023"/>
    </dbReference>
    <dbReference type="GeneID" id="1099196"/>
    <dbReference type="KEGG" id="sco:SCO3760"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3820"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025057_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2M1"/>
    <dbReference type="OMA" id="VFCHSYG"/>
    <dbReference type="PhylomeDB" id="Q9F2M1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176658" evidence="1">
        <location>
            <begin position="28"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC10298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="33207" checksum="33D85DE68551331E" modified="2001-03-01" version="1">MGRFRRVLTTAVLTTLLVGGTAGWASASSASVPGGPLPGTAAWLADDFLGRELPDPGTATPAEVAAFFAGLSDVQRHRLAEDHPAVVGNLDGVPVHLRYEANAPAGDRVLAYDPRGRGTIARVAGDLENAAHVSVIVPGSDIDAETFDRTAQRAADLQAAAGDDTAVIAWAGYTTPSGIGPDLATGRLAEAGAERLARLTEGLDAAGLPDPSLFCHSYGSVVCGLAADDTDARDIVVMGSPGMRADDVGALGTDAHVWAAKSPDDWIDRVPNVEFLGLGHGADPTSPGFGATVLPADDVPAHDEYFTPGTSTLAAFAAIADGERP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-09-26" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F315</accession>
    <accession>Q9ZH59</accession>
    <name>CLPP1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 1</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP1</name>
        <name type="ordered locus">SCO2619</name>
        <name type="ORF">SCC80.04c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="32" first="505" last="517">
            <title>Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces.</title>
            <authorList>
                <person name="de Crecy-Lagard V."/>
                <person name="Servant-Moisson P."/>
                <person name="Viala J."/>
                <person name="Grandvalet C."/>
                <person name="Mazodier P."/>
            </authorList>
            <dbReference type="PubMed" id="10320574"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01364.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="815" last="825">
            <title>Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigmaR in actinomycetes.</title>
            <authorList>
                <person name="Kim M.S."/>
                <person name="Hahn M.Y."/>
                <person name="Cho Y."/>
                <person name="Cho S.N."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="19682253"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06824.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Probably partially responsible for degradation of ECF sigma factor SigR prime.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Expressed from 2 promoters, 1 of which (clpP2) is positively regulated by the thio-oxidizing agent diamide, probably via SigR. Probably a clpP1-clpP2 operon.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">A double clpP1-clpP2 deletion increases the stability of ECF sigma factor SigR prime from 10 to 23 minutes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AF071885">
        <property type="protein sequence ID" value="AAC70947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAC09995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626855.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976180.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F315"/>
    <dbReference type="SMR" id="Q9F315"/>
    <dbReference type="STRING" id="100226.SCO2619"/>
    <dbReference type="MEROPS" id="S14.008"/>
    <dbReference type="GeneID" id="1098053"/>
    <dbReference type="KEGG" id="sco:SCO2619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2665"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_4_1_11"/>
    <dbReference type="InParanoid" id="Q9F315"/>
    <dbReference type="OMA" id="TIQAENM"/>
    <dbReference type="PhylomeDB" id="Q9F315"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179664" description="ATP-dependent Clp protease proteolytic subunit 1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC70947." evidence="3" ref="1">
        <original>GKR</original>
        <variation>RQ</variation>
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="19682253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="219" mass="23229" checksum="235A828E5B1E0BDD" modified="2001-03-01" version="1">MRRPGAVVRRAGGYVTNLMPSAAGEPSIGGGLGDQVYNRLLGERIIFLGQPVDDDIANKITAQLLLLASDPDKDIFLYINSPGGSITAGMAIYDTMQYIKNDVVTIAMGLAASMGQFLLSAGTPGKRFALPNAEILIHQPSAGLAGSASDIKIHAERLLHTKRRMAELTSQHTGQTIEQITRDSDRDRWFDAFEAKEYGLIDDVIATAAGMPGGGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F398</accession>
    <name>Q9F398_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7577</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631620.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031759.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7577"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="GeneID" id="1103015"/>
    <dbReference type="KEGG" id="sco:SCO7577"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7692"/>
    <dbReference type="eggNOG" id="COG3940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_7_0_11"/>
    <dbReference type="InParanoid" id="Q9F398"/>
    <dbReference type="OMA" id="FMGSGEC"/>
    <dbReference type="PhylomeDB" id="Q9F398"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176673" evidence="4">
        <location>
            <begin position="47"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="369" mass="39859" checksum="E1E9388D5D2195D4" modified="2001-03-01" version="1">MPPLTGSPPNGTFKLSRPVRGTVAALVSGALVALLLLVTSAGSAQADQTALRAADPSVIRVGGTYVSVQSTGGGIAVRQAASTAALAAAPARQVWSDARGRGEVWAPEIVRDGGRYYIYFSAGRGAAHRMYVISSTAADSGYTAESQLALPDDKWAIDGTLFTFEGQRWFVWSGWAGDTNVEQNLYIARMSGPTTPTGARYVISQPRESWERVVGNPFINEGPEPVMDPNGQLHIAYSANGSWSDQYCLADLRLRAGGDPTYVWDWYKSNGCLFGSHRATMMAGWDPTLYVDGPGHHSFVLLDGDIATSPPAGPRFPLMFHAVAKGTPYSWENRHWYTGTFCWWGGTTYSRANVPGPTSDTGWSLKFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3C0</accession>
    <name>Q9F3C0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative solute binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7555</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631598.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971589.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7555"/>
    <dbReference type="GeneID" id="1102993"/>
    <dbReference type="KEGG" id="sco:SCO7555"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7669"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_2_3_11"/>
    <dbReference type="InParanoid" id="Q9F3C0"/>
    <dbReference type="OMA" id="EQQAHIF"/>
    <dbReference type="PhylomeDB" id="Q9F3C0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176677" evidence="1">
        <location>
            <begin position="31"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="436" mass="46836" checksum="D458690F794877CC" modified="2001-03-01" version="1">MGTLGSLRRKAVATAAAVGALALVVGCSSGDDSATGGGKKDGKVTITMGMYGVMGIKETGLLEQYEKENPDVDIKAEIAGDEQTYYTALQTRLAAGKGLKDIQGIEIGRAKEITETQADKFADFSDVPGTDHFLPWKESQISTEDGKVLGLGTDIGPMAVCYRKDYFEKAGLPTDREEVAKLWAGDWKKYVEVGRDFKKGFKGGDVAYMDAASGLFNAMVYGYPEQYYDDKGELIYDSNPAVKEAWNLSADAAEDGLTAKLRQFQPGWDPGLANGTFATAVCPAWMLSHISEKAGDANKGKWDVAKAPKGANWGGSFLGVVEQSPVKEEAKKLVAWLTAPEQQAHIFKEIGNIPSSRTALDSPEVKNAKSEYFSGAPIGQIFGAAAQEIPDKQVLGRKDGTIKDTFSQGLALIEQGDAKRDEAWKTTGERIEKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3G8</accession>
    <name>Q9F3G8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4532</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628695.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974409.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4532"/>
    <dbReference type="GeneID" id="1099972"/>
    <dbReference type="KEGG" id="sco:SCO4532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4605"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1721281_0_0_11"/>
    <dbReference type="OMA" id="DIAATHC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="2">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="153" mass="16349" checksum="3E043E3D1A11D703" modified="2001-03-01" version="1">MRTQVRGWLADRRTRLDDRGSGAGAVIIFALVFLSLSAFVIDGGMSISKRERAADIAEQAARYAAQDIDREALYDDVGGPAPINYENCNARVKAFAAEMDMTGADIAATHCVTADAAQVQVEVQLTYSPVFTGMFYGGDVVVHGEAVAENEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L8</accession>
    <name>Q9F3L8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5246</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629392.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973724.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5246"/>
    <dbReference type="GeneID" id="1100687"/>
    <dbReference type="KEGG" id="sco:SCO5246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5330"/>
    <dbReference type="eggNOG" id="COG0025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_8_2_11"/>
    <dbReference type="InParanoid" id="Q9F3L8"/>
    <dbReference type="OMA" id="SYRWPIG"/>
    <dbReference type="PhylomeDB" id="Q9F3L8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="8"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC05973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="56896" checksum="4A37436340E91B15" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3N0</accession>
    <name>Q9F3N0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7657</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631697.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031808.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7657"/>
    <dbReference type="GeneID" id="1103095"/>
    <dbReference type="KEGG" id="sco:SCO7657"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7777"/>
    <dbReference type="eggNOG" id="ENOG50333PP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523416_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F3N0"/>
    <dbReference type="OMA" id="ANVWNAG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016641">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001695">
        <property type="entry name" value="Lysyl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01186">
        <property type="entry name" value="Lysyl_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176686" evidence="2">
        <location>
            <begin position="40"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="585" mass="61726" checksum="3E52327AEF8BE295" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC91</accession>
    <name>Q9FC91_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1222</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625511.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977609.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1222"/>
    <dbReference type="GeneID" id="1096645"/>
    <dbReference type="KEGG" id="sco:SCO1222"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1221"/>
    <dbReference type="eggNOG" id="COG1834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057463_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC91"/>
    <dbReference type="OMA" id="GTGFRTT"/>
    <dbReference type="PhylomeDB" id="Q9FC91"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="288" mass="31515" checksum="7DC3508A393D3FB2" modified="2001-03-01" version="1">MTESRVQRRRRFVVCEPRHFAVQYAINPWMSTGRPVDVIRALDQWQALVDTYRAHGHTVDTVAPVPGLPDMVFAANCAVVVEGRVFGSLFHAPERRPESVPFEAWFKTEGFEVHHPESVCEGEGDLVPAGRWILAGTGFRTTRAAHREVQEFFGVPVISLTLVDPYFYHLDTALFVLDDGTGGEGRSGGSAGSGGNIAYYPGAFSPGSREVLERLYPDAVIATREDALAFGLNSVSDGRHVFIAPEARGLADRLAGRGYVPVPVDLSEFHKAGGGIKCCTQEIRETRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCI4</accession>
    <accession>Q9K4B4</accession>
    <name>Y5204_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0182 protein SCO5204</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5204</name>
        <name type="ORF">2SC3B6.28</name>
        <name type="ORF">SC7E4.01</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0182 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD55225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733657.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973771.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCI4"/>
    <dbReference type="SMR" id="Q9FCI4"/>
    <dbReference type="STRING" id="100226.SCO5204"/>
    <dbReference type="GeneID" id="1100645"/>
    <dbReference type="KEGG" id="sco:SCO5204"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5287"/>
    <dbReference type="eggNOG" id="COG1615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007733_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FCI4"/>
    <dbReference type="OMA" id="HLRYPQD"/>
    <dbReference type="PhylomeDB" id="Q9FCI4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000157728" description="UPF0182 protein SCO5204">
        <location>
            <begin position="1"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="943"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109555" checksum="C30AB3349CA9E410" modified="2002-01-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3C2</accession>
    <accession>Q7B053</accession>
    <name>Q9K3C2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nrdB</name>
        <name evidence="8" type="ordered locus">SCO5225</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2002" name="Microbiology" volume="148" first="391" last="404">
            <title>Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth.</title>
            <authorList>
                <person name="Borovok I."/>
                <person name="Kreisberg-Zakarin R."/>
                <person name="Yanko M."/>
                <person name="Schreiber R."/>
                <person name="Myslovati M."/>
                <person name="Aaslund F."/>
                <person name="Holmgren A."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
            </authorList>
            <dbReference type="PubMed" id="11832503"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">A3</strain>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="54" first="1022" last="1035">
            <title>Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation.</title>
            <authorList>
                <person name="Borovok I."/>
                <person name="Gorovitz B."/>
                <person name="Yanku M."/>
                <person name="Schreiber R."/>
                <person name="Gust B."/>
                <person name="Chater K."/>
                <person name="Aharonowitz Y."/>
                <person name="Cohen G."/>
            </authorList>
            <dbReference type="PubMed" id="15522084"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04325.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2005-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Borovok I.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <reference evidence="7" key="5">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="2512" last="2520">
            <title>Coenzyme B12 controls transcription of the Streptomyces class Ia ribonucleotide reductase nrdABS operon via a riboswitch mechanism.</title>
            <authorList>
                <person name="Borovok I."/>
                <person name="Gorovitz B."/>
                <person name="Schreiber R."/>
                <person name="Aharonowitz Y."/>
                <person name="Cohen G."/>
            </authorList>
            <dbReference type="PubMed" id="16547038"/>
            <dbReference type="DOI" id="10.1128/JB.188.7.2512-2520.2006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <reference evidence="7" key="6">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="7635" last="7644">
            <title>The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons.</title>
            <authorList>
                <person name="Grinberg I."/>
                <person name="Shteinberg T."/>
                <person name="Gorovitz B."/>
                <person name="Aharonowitz Y."/>
                <person name="Cohen G."/>
                <person name="Borovok I."/>
            </authorList>
            <dbReference type="PubMed" id="16950922"/>
            <dbReference type="DOI" id="10.1128/JB.00903-06"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AJ276618">
        <property type="protein sequence ID" value="CAB82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629372.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030122.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5225"/>
    <dbReference type="GeneID" id="1100666"/>
    <dbReference type="KEGG" id="sco:SCO5225"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5309"/>
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    </dbReference>
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    <dbReference type="UniPathway" id="UPA00326"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB94610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="39653" checksum="0FC6E127FE503F46" modified="2000-10-01" version="1">MTTETPAHPTTKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWHVEEVDLHSDVADLAKLSPMEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPEDRAAAFAAVENIPSIREKAEFCFRWMDSVESIDRLETKADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFDVVDTVRKEEPELFDDQLREQVTDMLREAVEAELQFARDLCGDGLPGMNTDSMRQYLECVADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLSEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Z8</accession>
    <name>Q9K3Z8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1096758"/>
    <dbReference type="KEGG" id="sco:SCO1335"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1341"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="InParanoid" id="Q9K3Z8"/>
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    <dbReference type="PhylomeDB" id="Q9K3Z8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="24619" checksum="4349273925512180" modified="2000-10-01" version="1">MTRPITVVTGGSRGIGAATCLRLAADGHDVVVGYARDSTAAETVVAGVRDAGGRGVAVRADTSVEADVERLFDVAEERLGPVTGLVNNAAVTGPLGRLADSDTADLRRVLDVNLLGVLLCARRAARLMTPRGSGAIVNVSSGAATLGSPGEYVHYAASKAGVDAVTLGLAKELGPDGIRVNAVAPGVIDTGMHAAAGDAGRAARMGAAVPMGRAGRAEEIAAAISWLLSPDASYTTGTVLRVAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K400</accession>
    <name>Q9K400_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1333</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625618.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027727.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1333"/>
    <dbReference type="GeneID" id="1096756"/>
    <dbReference type="KEGG" id="sco:SCO1333"/>
    <dbReference type="eggNOG" id="ENOG5031BF7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055822_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="35147" checksum="5A1FA5ECEFB64EDD" modified="2000-10-01" version="1">MHHERSTHDARRPNHPQYFPGQPPFADGNGQPWPHVEEFTPDTDMVFGPHATDAYAGPLAPPDTDWDPAAELAFMLQGTHERRQPTDFHEPETSPQSPADGAPQGDPYPATAPLGRRRRPRRRARRRRDISPLRVASLTAAALAAVVASSVSLLSGMASYEPLRLTATTQASDGVVAWWPMLVYGPWLVASLAVLRAALHRRRAVHSWAVVLLFSAIAMLLCVLQAARTPEDAAAASLPGLASLVCFQQVVRQITLSRPPRRAAPRHHRHSQGDRSTASGEVRNPRGKDGNGRRQPSAPGTVRNRPPQGAAPDRGRARPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K459</accession>
    <name>Q9K459_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7226</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7226"/>
    <dbReference type="GeneID" id="1102664"/>
    <dbReference type="KEGG" id="sco:SCO7226"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7326"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116732_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K459"/>
    <dbReference type="OMA" id="ALVYPRE"/>
    <dbReference type="PhylomeDB" id="Q9K459"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="15639" checksum="E8C829C76639A78A" modified="2000-10-01" version="1">MAVMDPWLIWLIVSAVLVLAEIFTLTAALGMLGVAALITAGSAAAGLSTPFQFLVFTVVSAVTLFFLRPVALRHLVQPQTQRFGVDALVGQAAYVVSDVTGREGRVRIGGEEWTARSYDETLVIPRGATVDVLEISGTTAFVYPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4G2</accession>
    <name>Q9K4G2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4176</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628352.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974794.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4176"/>
    <dbReference type="GeneID" id="1099616"/>
    <dbReference type="KEGG" id="sco:SCO4176"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4241"/>
    <dbReference type="eggNOG" id="COG1813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="TSLWHFA"/>
    <dbReference type="PhylomeDB" id="Q9K4G2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="31584" checksum="12510B3E029E1142" modified="2000-10-01" version="1">MPQRRAITGRSQEPRARFAEELRLLRNGRGVSLRGVAEVVGWDASQFGKMEHGHTLGGPEIVEALDQYYGTGGMLLTLWELAVADPTQFREQYRRYMILEAEAISLWYYAVSAPPGLLQTAGYAREALAAGWLTVPELEQQVEARLGRRQLLEGDTPPPFRVILSEAVLRTLLRDMGAWREQLTHLVEMSERANITLHVLPFSAGRHGLTNTDVMFLRLPNGRVVAYIENDLRGELVEENASVELLQRRYDSTRDLALSPAESREFILRTLEEAPCEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK1</accession>
    <name>Q9KXK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2319</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626566.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028277.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2319"/>
    <dbReference type="GeneID" id="1097753"/>
    <dbReference type="KEGG" id="sco:SCO2319"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2356"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092076_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KXK1"/>
    <dbReference type="OMA" id="VIEHTWH"/>
    <dbReference type="PhylomeDB" id="Q9KXK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041642">
        <property type="entry name" value="KstR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17925">
        <property type="entry name" value="TetR_C_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="27149" checksum="A88638E9843BA260" modified="2000-10-01" version="1">MPSGSGDSRHGTAHGRAGLGEIRTRDPGKQVTKVDNPTATAPGPAHRSTAPPLTERQRERRRRILHATAQLACRGGFEAVQMREVAESSQVALGTLYRYFPSKVHLLVATMHDQLERLHGTLRKSPPTGETAADRVAQTLMRAFGALQREPRLAEAMARALTFADRSVSPEVDQVSRQTTAIILDAMGGLENPTPEQLSAVRVVEHTWLSTLITWLAGRTSLAQVRVDIETVCRLIDLTEAGTGEAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXL6</accession>
    <name>Q9KXL6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4341</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628512.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1099781"/>
    <dbReference type="KEGG" id="sco:SCO4341"/>
    <dbReference type="eggNOG" id="ENOG50325B6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2248509_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="104" mass="11377" checksum="A8793FB5E6B413D8" modified="2000-10-01" version="1">MKERPRHPCTVHPREEREAHVPPSGGGLAHACAPHRKGPHPVAISFGHDRPWGGVSQHEYLRMAQNPTHQLAYRVHFAAIGWADRHGHAGFAPGRLAALAGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXM8</accession>
    <name>Q9KXM8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4329</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628500.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029582.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4329"/>
    <dbReference type="TCDB" id="2.A.1.21.18">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="GeneID" id="1099769"/>
    <dbReference type="KEGG" id="sco:SCO4329"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4398"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025436_1_2_11"/>
    <dbReference type="InParanoid" id="Q9KXM8"/>
    <dbReference type="OMA" id="KAYGVVR"/>
    <dbReference type="PhylomeDB" id="Q9KXM8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="463" mass="47488" checksum="95BD46C6D00F85BD" modified="2000-10-01" version="1">MAAARTEFKRGSRWRGPGSRFRAVGRALRLPVTGTARGIRRATHAHGAGESGLGKLIELHGVNGAGDVMITVALASTVFFSVPTDEARGRVALYLAITMAPFTLLAPVIGPLLDRLPHGRRAAMATAMGARAVLALVLSGAVVTGGIELYPAALGVLVASKAYGVVRSAVVPRLLPPRVSLVKANSRVTLCGLLATGAAAPIGAGLQQVGPRWPLYGAFVIFVAGTVLSFTLPRKVDSARGEDRALLAADEAHLPGPLRGRSKRPGLRTVGPAVTHALAANAAIRCLTGFLIFFLAFLLRVHPMTGQSAAVSLGIVGVAAGAGNALGTAVGAWLRSRAPEVIIVTVVVIVLGAAVVAAVFFSAFLVACLAAVAGFAQALAKLSLDALIQRDVPEQVRTSAFARSETLLQVSWVLGGAVGIVLPLNGTLGLSVAAAIIAAGWLTTVRGLLDSARHGGRTRPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXV9</accession>
    <name>Q9KXV9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dimeric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4282</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628454.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029552.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4282"/>
    <dbReference type="GeneID" id="1099722"/>
    <dbReference type="KEGG" id="sco:SCO4282"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4350"/>
    <dbReference type="eggNOG" id="ENOG50349V5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888311_0_0_11"/>
    <dbReference type="OMA" id="YGYPNSV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="3">
        <location>
            <begin position="188"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="32640" checksum="6E5AE5B8256201A0" modified="2000-10-01" version="1">MTPGNNGASTPEDDDPFGYLYADGQANGAQPPSGGYGYPNSVNRVRPVGTRQYGAPQGQGAQTAAYGQAAPPQQGAYGQPQGAYGQPNAHYAAPETFPGGGGPGGPQQSSGRGGGSGRRGPNTKGLLIGAVAVVAAVVIGIAVAMTSSGSDDDKGGNEAGGDPAPSQSASTEPSPSASEGAEDEVELPTTDAKALRLSPGMGTASDFEGAESDGGVYVTGFNQVGAKVTWTVDGIEKAGGYRLNVRYGIPGKDADATLVINGKASARPLNMKNFGGTPEGDWEKGWQTTWANVNLAKGTNTIELACNDGNKCDLVLDKLSLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY11</accession>
    <name>Q9KY11_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">SCO7327</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631381.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031589.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7327"/>
    <dbReference type="GeneID" id="1102765"/>
    <dbReference type="KEGG" id="sco:SCO7327"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7430"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_1_11"/>
    <dbReference type="InParanoid" id="Q9KY11"/>
    <dbReference type="OMA" id="HGFRVLH"/>
    <dbReference type="PhylomeDB" id="Q9KY11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="288"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="472"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="776"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1212"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="707"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAB92873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1331" mass="142139" checksum="6F61DE6C617692A7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY70</accession>
    <name>Q9KY70_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4794</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628951.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029868.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4794"/>
    <dbReference type="GeneID" id="1100235"/>
    <dbReference type="KEGG" id="sco:SCO4794"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4870"/>
    <dbReference type="eggNOG" id="ENOG5032ZIA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1609913_0_0_11"/>
    <dbReference type="OMA" id="LHGALTM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="18468" checksum="A71F9EB8B56FC365" modified="2000-10-01" version="1">MAAADRAATASDRYALRGPASSRRVMTVMPDRGRVGDVSCYGSAGAGRCPGASGPSLGSGLMDVLIHLFVGLHIIGIASLLGGFLTQMKAMGQGAARFTPAMLHGALTMLVTGAVLVGLNQAQDYSVDNVKIGVKLAVLIVILGLVYVKRDEEKVEKPLFGLVGALTLANIFIAVLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI5</accession>
    <name>Q9KYI5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="5">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ribA</name>
        <name evidence="7" type="ordered locus">SCO2687</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="5"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626921.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028515.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2687"/>
    <dbReference type="GeneID" id="1098121"/>
    <dbReference type="KEGG" id="sco:SCO2687"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2743"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_1_11"/>
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        <property type="organism ID" value="5998"/>
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        <property type="reaction ID" value="UER00400"/>
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    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTP cyclohydrolase II activity"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
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        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB92253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="23430" checksum="318BAEB45289963C" modified="2000-10-01" version="1">MRTEENEDVIVAPSPAVQVRARVEVPIDVPGLGPRASTMVSFDGLHDGREHVALLMPGWEKKSDPLVRVHSECLTGDVFGSQRCDCGPQLHEALAMCSHEGGIILYLRQEGRGIGLYNKFDAYLLQDGGLDTFEANAVLNFSHDLRDYRVAAEMLSALGVPRIRLLSNNPEKGNQLRSHGVVISDVVATGTFVNENNQAYLTAKRERAGHALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ07</accession>
    <name>Q9KZ07_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2230</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2230"/>
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        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1097663"/>
    <dbReference type="KEGG" id="sco:SCO2230"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2267"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="InParanoid" id="Q9KZ07"/>
    <dbReference type="OMA" id="WYAYAMI"/>
    <dbReference type="PhylomeDB" id="Q9KZ07"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB90878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="334" mass="37933" checksum="A1B2888A260A402B" modified="2000-10-01" version="1">MTVAIDRATGKRRGDRTPRPGLGRRLKDGYQKHWYAYAMIAPVAVVIGVLVLYPLGYGLYLTLTDANSLNSARTIGVNEIEATYKFVGLDNYADILWGPTAYDRFWSHFIWTIVWTAVCVGLHFFIGLGLALLLNQKLRGRTFYRLILVLPWAVPTFVTVFGWRFMLADQGIINSALDWLHLPTPAWLEDTFWQRFSAIMVNTWCGVPFMMVSLLGGLQSIDNSLYEASEMDGANAWQRFRYVTLPGLRSVSSTVVLLGIIWTFNQFAVIFLLFGNTAPDAQILVTWAYQLGFGQQPRDFAQSAAYGILLLAILIVFTSFYRRWLNRNEQQLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZF7</accession>
    <name>Q9KZF7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6996</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631061.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972148.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6996"/>
    <dbReference type="GeneID" id="1102434"/>
    <dbReference type="KEGG" id="sco:SCO6996"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7098"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_5_2_11"/>
    <dbReference type="OMA" id="STARHEC"/>
    <dbReference type="PhylomeDB" id="Q9KZF7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="191" mass="21325" checksum="C378B4AB1B45A882" modified="2000-10-01" version="1">MDRADVGALVQSAADGDAAAWKSLVDGLGPLVWSVARSHGLSDADAHEVYQTAWFRFAQHLGRIREPEKTGSWLASTARHECLKLLKASKRWTPTDDPQLLDRPSEERTPEESVLDSEEAAAQTERVRLLWQEFEELGERCRQLLRVLISSPPPSYQEVSAALGIAVGSIGPMRQRCLRRLRARLEARGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZH5</accession>
    <name>Q9KZH5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6977</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631042.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031349.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6977"/>
    <dbReference type="GeneID" id="1102415"/>
    <dbReference type="KEGG" id="sco:SCO6977"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7076"/>
    <dbReference type="eggNOG" id="COG1830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056329_0_0_11"/>
    <dbReference type="OMA" id="YERWGKA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="31565" checksum="DB19BE7942B33082" modified="2000-10-01" version="1">MSISISSIPDLTTVRARHPEAIAEAAARRVRRPLIGDSGRLMIVAADHPARGALGVGDRGLAMANRADLLERLCTALSRPGVDGVLATADVLEDLLLLGVLENKVVMGSMNRGGLAGAAFEMDDRFTGHRAEDIARLRFDAGKLLLRIDYDDPGSLTTMEASARAVDAMAARELPLFVEPFISRRIDGRVRNDLSAEAVTRSVAIASGLGGTSAYTWLKLPVTRNPDDMAEVLETSTLPAVLLGGDIGGSPADQTAAYERWRKALRLPTVQGMVVGRSLLYPAGGSVEEAVDTAVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZI6</accession>
    <name>Q9KZI6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1159</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625451.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977672.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1159"/>
    <dbReference type="GeneID" id="1096582"/>
    <dbReference type="KEGG" id="sco:SCO1159"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1157"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZI6"/>
    <dbReference type="OMA" id="RTMVEMD"/>
    <dbReference type="PhylomeDB" id="Q9KZI6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="15168" checksum="F518AC7CEBCF004D" modified="2000-10-01" version="1">MIQNPGTGTARRARELDWLLDDLVGRVHEVRHAVVLSNDGLAVGASHGLAREDGEHLAAVASGFHSLAKGAGRHFGAGGVHRTMVEMDDGYLFVAAAGDGSCLAVLTAVTADIGLVAYEMARLVRRVGEHLHTAPRAAARPPFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZP4</accession>
    <name>Q9KZP4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1388</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625671.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027759.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1388"/>
    <dbReference type="GeneID" id="1096811"/>
    <dbReference type="KEGG" id="sco:SCO1388"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1396"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017652_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZP4"/>
    <dbReference type="OMA" id="NRPIMEH"/>
    <dbReference type="PhylomeDB" id="Q9KZP4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="384"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="532"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="640"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="831" mass="89609" checksum="4C15D1962456DA8B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZX4</accession>
    <name>Q9KZX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4452</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628619.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029664.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4452"/>
    <dbReference type="GeneID" id="1099892"/>
    <dbReference type="KEGG" id="sco:SCO4452"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4522"/>
    <dbReference type="eggNOG" id="COG4941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035311_1_1_11"/>
    <dbReference type="OMA" id="AAETDWV"/>
    <dbReference type="PhylomeDB" id="Q9KZX4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="383" mass="41557" checksum="3A199D702926121B" modified="2000-10-01" version="1">MDEALVRSLTPGVLTVLVRRGADFAAAEDAVQDALVEAVRGWPADPPRDPKGWLVTVAWRRFLDAARADTARRRREDRVEEEPVPGPAPDVDDTLQLYFLCAHPSLTPSAAVALTLRAVGGLTTRQIARAYLVPEATMAQRISRAKRTVSGVRFDRPGDVATVLRVLYLVFNEGYSGDVDLAAEAVRLTRQLAASVDHPEVAGLLALMLLHHARRAARTAPDGSLVPLAEQDRGRWDTASIAEGVRILQAALARDRLGEFQAQAAIAALHADAPTAGETDWPQIVEWYDELARLTDNPVVRLNRAVAVGEADGPRAGLAALAELDGTLPRHTAVAAYLHERDGDVDTAARLYAEAALKAPALAERDHLTRQAARLNSRRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L056</accession>
    <name>Q9L056_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2979</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627202.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975832.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2979"/>
    <dbReference type="GeneID" id="1098412"/>
    <dbReference type="KEGG" id="sco:SCO2979"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3038"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L056"/>
    <dbReference type="OMA" id="IGSYVWM"/>
    <dbReference type="PhylomeDB" id="Q9L056"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB87329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="427" mass="45366" checksum="5A53812B54BE2A2B" modified="2000-10-01" version="1">MTGTRRSVAALFLLPALVLLGALVVYPIGYSLIRSFYDQSGDSFAGFDNYETLFTDDGIRTALKNNVIWVVFAPTVATALGLIFAVLTERIRWGTAFKLVVFMPMAISMLAAGIIFRLVYDQDPDKGVANAVWVGVHDTFAESSAFPKAHPGRDSPLKPAGGGAFITKQPVGAGTPVALPLVGVAPDLMPDGAKKAATAEPADGKVTGTTWQDFTRGKGVGRLGGVDAAELGYAGMKIEAVKDGEVVATTTAAGDGTFTLPAAADGALLRLPADNFKEAYNGLNWLGPSLVTPAIIGSYVWMWAGFAMVLIAAGLAGMPRELLEAARVDGANEWQVFRRVTVPLLAPVLAVVVVTLMINVLKVFDLVFIIAPGSSQDDANVLALELYRKGFASDQPGVASAIAVFLLLLVIPVMWFNVRRLRREVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L057</accession>
    <name>Q9L057_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2978</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975833.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2978"/>
    <dbReference type="GeneID" id="1098411"/>
    <dbReference type="KEGG" id="sco:SCO2978"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3037"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027068_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L057"/>
    <dbReference type="OMA" id="KPGFWYR"/>
    <dbReference type="PhylomeDB" id="Q9L057"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176797" evidence="2">
        <location>
            <begin position="37"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="465" mass="48477" checksum="AB1FC6016DF128EF" modified="2000-10-01" version="1">MRTSSTIRTRGTVKRTTRAAAALAAGALALSLTACGGDEDNGGGDGGDEGGGAKQPASSVTLPKLDGESLEVAAVWTGTEQENFKKVLAEFEKRTGAKVTFVPAQDPIINFLGSKIAGGAPPDVAMLPQPGAIKQAVDKGWAKPLGAEATKELGENYSQGWQDIGKVGGKQYGVYYKAANKSLIWYNAQVFENAGAAEPKTWDELLNAAQMVYDSGVTPFSVGGADGWTLTDWFENVYLSQAGPEKYDQLAKHEIKWTDPSVKDALTTLAEIWGKKDFVAGGASGALQTEFPASVTQTFTGGDQPKAGMVYEGDFVQVNIGETKAKVGTDAKVFPFPAVGDTAPVVSGGDAAVVFKDSKAAQALATWLASPDAAGIQAKLGGFLSPNKSIDSSVYPNEVQKKIAEALVAAGDDFRFDMSDQAPQAFGGTPGKGEWKTLQDFLKNPKDVAGAQAKLEADAAAAYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0H5</accession>
    <name>Q9L0H5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4782</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4782"/>
    <dbReference type="GeneID" id="1100223"/>
    <dbReference type="KEGG" id="sco:SCO4782"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4856"/>
    <dbReference type="eggNOG" id="ENOG502ZBYP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260837_0_0_11"/>
    <dbReference type="OMA" id="SSKENWY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB82021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="219" mass="22701" checksum="C65145904239FF50" modified="2000-10-01" version="1">MCEDTKVDVDIEGLPGEIAAGSGWHEFSLNVANDSGSTLQNLEYLAGASADRDGEKLFESKKVGLQAWNPEDRTWEDLDELGYAVGYIGYTDELAPDYEVAVPMRINVRADAPVGAGFTLGATIYGDADGECTGFGDVAYRFRIVAPGTDTDGTRPQEGGKAPVTVRKPAAGTPEVTGSLAATGSSSALPVIGLVGGLAVVVGGGAVFVVRRRRAGSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1D9</accession>
    <name>Q9L1D9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5466</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629603.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973532.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5466"/>
    <dbReference type="CAZy" id="GH25">
        <property type="family name" value="Glycoside Hydrolase Family 25"/>
    </dbReference>
    <dbReference type="GeneID" id="1100906"/>
    <dbReference type="KEGG" id="sco:SCO5466"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5550"/>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090666_0_0_11"/>
    <dbReference type="OMA" id="GRSYVNP"/>
    <dbReference type="PhylomeDB" id="Q9L1D9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044275">
        <property type="term" value="P:cellular carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="20794" checksum="F8A3732E4E380E8C" modified="2000-10-01" version="1">MLRGIDVSAYQSANYDTDGLSFVFVKATEGRSYVNPKLAAQTERARDAGLVVGFYHFLWPGNLTAQAEYFVSKAPDRKGDVLAVDWETNGEGTHPSNAEKDSFIRRLKTLRPDNRVVLYCNRNFWLNVDTTSYAGDGLWIADYVSAGKPRIQAKWRFHQYTDDPVDTNVADFASKAALKEWAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Q4</accession>
    <name>Q9L1Q4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6860</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630930.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031245.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6860"/>
    <dbReference type="GeneID" id="1102299"/>
    <dbReference type="KEGG" id="sco:SCO6860"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6970"/>
    <dbReference type="eggNOG" id="ENOG5032IHK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1854032_0_0_11"/>
    <dbReference type="OMA" id="VTAHPRY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB72365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="16125" checksum="E2DE99CADEE80141" modified="2000-10-01" version="1">MLPPSWDHQPVPVTALTPDPLTPTRDITHAHFQAGDTVVVLKGVAGGELWGDAMRVVAPSWHTPTDEDGWRLRDPTGGDQSYVTAHPRYLVHLSRRCPDCLIFLRAMEDTLLKRFAGRDELIDCGWYTTTALGQLAHTADQRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1U8</accession>
    <name>Q9L1U8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar transporter sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2946</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627170.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975864.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2946"/>
    <dbReference type="GeneID" id="1098379"/>
    <dbReference type="KEGG" id="sco:SCO2946"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3004"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_11"/>
    <dbReference type="InParanoid" id="Q9L1U8"/>
    <dbReference type="OMA" id="TYGAMPF"/>
    <dbReference type="PhylomeDB" id="Q9L1U8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901982">
        <property type="term" value="F:maltose binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015768">
        <property type="term" value="P:maltose transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176830" evidence="1">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="432" mass="44850" checksum="D6B984AF866798B1" modified="2000-10-01" version="1">MKLAPRLAVLLAAAVVAATACAPQASDNSSSGKDEKSGTLRVWLFQEVNNKPKEKVVDAALADFEKAHADTKVTVEYIPVETRAQRIKAAFNDPKSAPDVVEFGNTDTAGYVKDGGLADISEEFAAWDEAKDADSTARQSVTVDGKVYGAPYFVGVRALYYRTDVFDELGLKAPRTLAELASTAKRVRAAKPDLYGLAVGGAYTYGAMPFIWANGGDIATGKGGSYASAIDSAAAQKGIKAYTSLFGDANCPAAKCAGMTGNDTVTAFASGKAAMAIGGDFSHQAMEAGAVKGKYAVVPLPGVEPGSIAPAFAGGNNIGVLKSTSHRTLAVDLMKRLASKKAQGELFDAMGFLPTFTDVRQQVAAREPFVKPFVDTLAAGTKFVPASPAWATIDSSLVLPTMFQEVVSGKKDVGAAAGDAARKMDDAFGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2H5</accession>
    <name>Q9L2H5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="5045" last="5050">
            <title>Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur.</title>
            <authorList>
                <person name="Shin J.H."/>
                <person name="Jung H.J."/>
                <person name="An Y.J."/>
                <person name="Cho Y.B."/>
                <person name="Cha S.S."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="21383173"/>
            <dbReference type="DOI" id="10.1073/pnas.1017744108"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 2-139 IN COMPLEX WITH ZINC</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626748.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007449657.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="PDB" id="3MWM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B=2-139"/>
    </dbReference>
    <dbReference type="PDBsum" id="3MWM"/>
    <dbReference type="SMR" id="Q9L2H5"/>
    <dbReference type="STRING" id="100226.SCO2508"/>
    <dbReference type="GeneID" id="1097942"/>
    <dbReference type="KEGG" id="sco:SCO2508"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2553"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_0_11"/>
    <dbReference type="InParanoid" id="Q9L2H5"/>
    <dbReference type="OMA" id="HDHVILT"/>
    <dbReference type="PhylomeDB" id="Q9L2H5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CollecTF" id="EXPREG_00001780"/>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001217">
        <property type="term" value="F:DNA-binding transcription repressor activity"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000269"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3MWM"/>
        </source>
    </evidence>
    <sequence length="139" mass="14711" checksum="DBA024A1BBB971F1" modified="2000-10-01" version="1">MTTAGPPVKGRATRQRAAVSAALQEVEEFRSAQELHDMLKHKGDAVGLTTVYRTLQSLADAGEVDVLRTAEGESVYRRCSTGDHHHHLVCRACGKAVEVEGPAVEKWAEAIAAEHGYVNVAHTVEIFGTCADCAGASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>Q9R339</accession>
    <name>Q9R339_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2736</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626968.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976064.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2736"/>
    <dbReference type="GeneID" id="1098170"/>
    <dbReference type="KEGG" id="sco:SCO2736"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2792"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_0_0_11"/>
    <dbReference type="InParanoid" id="Q9R339"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="PhylomeDB" id="Q9R339"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB66275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="47744" checksum="AF13DD986ED20C89" modified="2000-05-01" version="1">MSDNSVVLRYGDGEYTYPVIDSTVGDKGFDIGKLRAQTGLVTLDSGYGNTAAYKSAITYLDGEAGILRYRGYPIEQLAERSSFVEVAYLLINGELPTVDELSAFKGEITQHTLLHEDVKNFYKGFPRDAHPMAMLSSVVSALSTFYQDSHNPFDERQRNLSTIRLLAKLPTIAAYAYKKSIGHPFVYPANNLGYVENFLRMTFSVPAQEYELDPTVVAALDKLLILHADHEQNCSTSTVRLVGSSQANMFASISAGINALWGPLHGGANQSVLEMLEGIRDAGGDVDSFIRKVKNKEDGVRLMGFGHRVYKNFDPRAKIIKAAAHDVLSALGKSDELLDIALKLEEHALSDDYFVSRSLYPNVDFYTGLIYRAMGFPTEMFTVLFALGRLPGWIAQWHEMIKEPGSRIGRPRQIYTGVVERDFVPVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCV4</accession>
    <name>Q9RCV4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TetR-family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0857</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2006-10" db="PDB data bank">
            <title>Crystal structure of TetR-family regulator (SCO0857) from Streptomyces coelicolor A3.</title>
            <authorList>
                <consortium name="Midwest Center for Structural Genomics (MCSG)"/>
                <person name="Koclega K.D."/>
                <person name="Xu X."/>
                <person name="Chruszcz M."/>
                <person name="Gu J."/>
                <person name="Cymborowski M."/>
                <person name="Savchenko A."/>
                <person name="Edwards A."/>
                <person name="Minor W."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB65638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625157.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027396.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="PDB" id="2NP3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A/B=1-212"/>
    </dbReference>
    <dbReference type="PDBsum" id="2NP3"/>
    <dbReference type="SMR" id="Q9RCV4"/>
    <dbReference type="STRING" id="100226.SCO0857"/>
    <dbReference type="GeneID" id="1096280"/>
    <dbReference type="KEGG" id="sco:SCO0857"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.849"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_10_0_11"/>
    <dbReference type="InParanoid" id="Q9RCV4"/>
    <dbReference type="OMA" id="VITHYLT"/>
    <dbReference type="PhylomeDB" id="Q9RCV4"/>
    <dbReference type="EvolutionaryTrace" id="Q9RCV4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB65638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2NP3"/>
        </source>
    </evidence>
    <sequence length="212" mass="22322" checksum="A1ACEBCBAA4AAD80" modified="2000-05-01" version="1">MTGQAAGPAAGPAAGQATKHAGGRRPGETRTREAILTAARVCFAERGFDATSLRRIAETAGVDQSLVHHFYGTKENLFLQALELPGKIEEAITAAAQGGLDGIGERVVRAHLSVWDDVSSRPALMTMVRSAAIHRAAAARLRETATGILARALGGVITGEDAMLRTSMVATQLVGLAMMRYVAHLEPLASADTDTVARHYGRAVQAIVTDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCV9</accession>
    <name>Q9RCV9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0852</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625152.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027391.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0852"/>
    <dbReference type="GeneID" id="1096275"/>
    <dbReference type="KEGG" id="sco:SCO0852"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.844"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RCV9"/>
    <dbReference type="OMA" id="DMGSASY"/>
    <dbReference type="PhylomeDB" id="Q9RCV9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="21100" checksum="BEECB4BBA2A78098" modified="2000-05-01" version="1">MDLRAALAAHRLVAIVRGDDADAALRTVLTLAEEGVELIEVSLTGKDALQVIERARAALGPDRPLGAGTVLSADDAVAAHRAGADFAVTPGLGEGVTAARERGMPVLAGVMTPTDVITARALGATALKIFPAAQAGGPAYVKALRGPFPHETLVPVGGVDEAAARAHLAAGATAVGVGSPLIGDAADGGSLDGLRTRARAFRAAVREMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD52</accession>
    <name>Q9RD52_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0630</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624941.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027260.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0630"/>
    <dbReference type="GeneID" id="1096053"/>
    <dbReference type="KEGG" id="sco:SCO0630"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.613"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081840_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RD52"/>
    <dbReference type="OMA" id="TRCHIGD"/>
    <dbReference type="PhylomeDB" id="Q9RD52"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="18022" checksum="B10630BC2868CB31" modified="2000-05-01" version="1">MSSSRSSWNTRAETGADVPVIRDIVRAAFPTPEEAALVDALRADAGAWIEGLSLVAVDDSDRPVGHALLTRCHIGDSPALCLAPVAVRPEHQNSGAGAAAVRAALAAAGRLGEHHVVVLGHPEYYPRFGFGRASAHGIRLSIDVPDEALMVLTLDAAHPLPAGTVRYAAPFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD74</accession>
    <name>Q9RD74_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0803</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625104.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027367.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0803"/>
    <dbReference type="GeneID" id="1096226"/>
    <dbReference type="KEGG" id="sco:SCO0803"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.795"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_1_11"/>
    <dbReference type="InParanoid" id="Q9RD74"/>
    <dbReference type="OMA" id="VLHDIFA"/>
    <dbReference type="PhylomeDB" id="Q9RD74"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB66203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="35203" checksum="5D8ABF03C06317EB" modified="2000-05-01" version="1">MRGQGDMRGERDVRGEQDARRQRDARGQQRLAERFEEHRGQLKAVAYRMLGSLAEAEDAVQEAWLRLDRSEADGIDNLGAWLTTVTGRICLDLLRSRTARREEPMTEGFDSFVPDPVLRALPRADPEAEALHTDSVGIALLVVLERLEPAERLAFVLHDMFAVPFDDIAGVVERSPAATRQLASRARRRVRDATPAAEPDLGRQRRVVEAFLAASRAGDFEALVSVLHPDVVLRADAGAPARGVAASKVVRGARTVATGAFHFRHLAPLARVVLVNDAVGTVAVSDGRPVSVTYVTVADGLITGLYILSDPERLAGLDVSGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDP7</accession>
    <name>Q9RDP7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO2390</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626636.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028323.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2390"/>
    <dbReference type="GeneID" id="1097824"/>
    <dbReference type="KEGG" id="sco:SCO2390"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2431"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="InParanoid" id="Q9RDP7"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="PhylomeDB" id="Q9RDP7"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="8"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB62722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="43841" checksum="983DC0F9800582BE" modified="2000-05-01" version="1">MSSTNRTVVVTGIGATTPLGGDAASTWEGLVAGRSGVRPLEQEWAADQAVRIAAPAAVDPSEVIPRPQARRLDRSAQFALIAAQEAWKDAGYAGKAGESPAEDGAAHVDPDRLGAVIASGIGGVTTLLDQYDVLKEKGVRRVSPHTVPMLMPNGPSANVGLAVGARAGVHTPVSACASGAEAIGYAIEMIRTGRADVVVAGGTEAAIHPLPIAAFGNMMAMSKNNDDPQGASRPFDTARDGFVLGEGAGVLVLESAEHAAARGARVYAEAVGQGISADSHDIVQPEPEGRGISAALQNLLDGNDLDPAEIVHVNAHATSTPAGDIAELKALRKVLGDDVDHMAVSGTKSMTGHLLGGAGGVESVATVLALYHRVAPPTINVENLDPEAEANADIVRGEARKLPVEGRIAALNDSFGFGGHNVVLAFRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI60</accession>
    <name>Q9RI60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0118</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37017">
        <property type="entry name" value="T37017"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624458.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0118"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="DNASU" id="1095542"/>
    <dbReference type="GeneID" id="1095542"/>
    <dbReference type="KEGG" id="sco:SCO0118"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.95"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016508_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RI60"/>
    <dbReference type="OMA" id="WSDPVWI"/>
    <dbReference type="PhylomeDB" id="Q9RI60"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C2" evidence="8">
        <location>
            <begin position="307"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="509" mass="55595" checksum="1C99EBE0214DDCBA" modified="2000-05-01" version="1">MRMYDNPVISGFHPDPSVCRVGDDYYLVCSSFEYFPGLPLFHSKDLVHWEQIGNVLDRPGQLPLPVPGAKASGGLYAPTIRHHDGRYWVINTNIDGGGNFVVSARRPEGPWRDPVWIDLPGIDPDLAWEEDGTCWCAFSGPEGGINMARIDPVEGTVLEQPFVTWSGSGLKYPEAPHLYRIGDWWYLLIAEGGTERGHSVSVARSRSPRGPWQGAPSNPLLSHSGTPRPIQNTGHADLVEAPDGSWWMVLLGVRPRGFTPDVHVLGRETFLTPVEWDADGWPLLAPVPVSHAAPGGAWHPVPAPPTRDDFDKHSLAPHWISPFTRHEGSWSLTERPGWLLLGATGPTLDRPGYTFVGRRQQHHDCRVTALIDPGTGRGGLCVRLDEAHHYEVEAGDGEVRVVARIGPLRQTVARRPVPAGPQHLTVTIRTSDLVPASPELTDGGTTGPDTIAFGLGDPDTPDARPLAELDGRYLSTEVACGFTGRVIGMYATEGTVAFDWFEYVPTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIV2</accession>
    <name>Q9RIV2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625251.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027466.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0954"/>
    <dbReference type="GeneID" id="1096377"/>
    <dbReference type="KEGG" id="sco:SCO0954"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.951"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_2_11"/>
    <dbReference type="InParanoid" id="Q9RIV2"/>
    <dbReference type="OMA" id="IWPFWHR"/>
    <dbReference type="PhylomeDB" id="Q9RIV2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17575" checksum="8C60E71AF42095CE" modified="2000-05-01" version="1">MLIREATADDWPHIWPFWHRIVAAGETYAWDPDTSEEDARALWTSPGRRVYVAEDDTGAVVASAYLTPNYGGPAARIANAGFMVDPDRAGRGTGRALAEYVLDAARADGYRAMVFNAVVETNPAVRLWTSLGFTILGTVPDAFDHPRHGRVGLHIMHRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ76</accession>
    <name>Q9RJ76_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribosomal pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1625</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625900.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977201.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1625"/>
    <dbReference type="GeneID" id="1097056"/>
    <dbReference type="KEGG" id="sco:SCO1625"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1640"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ76"/>
    <dbReference type="OMA" id="HYFREVP"/>
    <dbReference type="PhylomeDB" id="Q9RJ76"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="103"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="35566" checksum="7E8BC47824CFA23A" modified="2000-05-01" version="1">MRRRTPPPPSPLPQRDGIDAVRVRLPADGPWSTVREYLTERLSAAGAGVVDGMFDAGVFVGADGRPVAGDAPYEPGMFVWFHRELPAEVPVPFPLEIVYRDAHIVVADKPHFLATTPRGGHVTQTALARLRRELDIPALGAAHRLDRLTAGLVLFTVRPGERGAYQGLFADRRVHKVYEAVAPYDAALALPRTVRSRILKERGVLAAREVAGEPNAVTRVELLAHRPEHGLGRYRLVPGTGQTHQLRVHLNALGVPILGDPLYPEVAAPVPAGDFRRPLQLLARELGFTDPVTGREHRFRSGRSLGAWTAYEDWAAREGRAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJF5</accession>
    <name>Q9RJF5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphatase SCF76.19c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0479</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624798.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027149.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0479"/>
    <dbReference type="GeneID" id="1095902"/>
    <dbReference type="KEGG" id="sco:SCO0479"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.457"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_0_11"/>
    <dbReference type="OMA" id="VDPLCGT"/>
    <dbReference type="PhylomeDB" id="Q9RJF5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="28241" checksum="F2E8D59DFCD9121A" modified="2000-05-01" version="1">MINLPVPHDETGARHDDTEVAIAAARAGAETVRARYGRRLTRFDKGGGDFATDADVAAEEAILGVIRAARPHDAICGEEGGRRGAADAARQWLVDPLCGTLNYAAGTMAVAVNVALRGGPAAVADPFGGEVLFTDGETARVRRDGHDTPLAPSAATRLVDVNLDPPFPGAPAFRAVDLIAHPGFVRRLRPRVLSTTLALAWVAAGKRAAYVTDGTGLTESVHFAAGIALCRAAGCVVTGVDGEPVGPVGRGLVAAADAGTHALLLSLIREGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJG0</accession>
    <name>Q9RJG0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0474</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624793.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027146.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0474"/>
    <dbReference type="GeneID" id="1095897"/>
    <dbReference type="KEGG" id="sco:SCO0474"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.452"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037853_0_0_11"/>
    <dbReference type="OMA" id="GAWTVDH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="415" mass="43855" checksum="8212D37F2D6A08BD" modified="2000-05-01" version="1">MEPTVRTHPTRRLPTALVLTAALLATGCSEQSDDGREPAATESSGTPHGYVEGAREAAEEQSRLILGDPGTGASRVLDLVTGKVHESEPVTGADGLSTDGRFGFFHTDRGTHVVDGGAWTVDHGDHVHYYRAAIRHVGDLPGGRGAEIRSDAAVTAATDPEGRTTLYDRTALEKGEVGPARTLDGVHAGAVVPYEEHLVALAGDDESAEVAVYDRSGRRVASPDATCERPAGDAVTRRGVVLGCADGALLVSAEDGTFTAERIPYGQDVPEKERATAFRHRAGSDTLTAPAGERAVWVLDVTDRDWTRVRTTGPVLAANTAGEGSPLLVLESDGALHGYDIATGRHTARTEPLLTRTAKTPAGAAAPVVEVDRSRAYVNDRTGKRVYEIDYNDALRVARSFDLDIAPGLMAETGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKI7</accession>
    <name>Q9RKI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627649.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028986.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3445"/>
    <dbReference type="GeneID" id="1098882"/>
    <dbReference type="KEGG" id="sco:SCO3445"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3507"/>
    <dbReference type="HOGENOM" id="CLU_212821_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="55" mass="5927" checksum="BF89F887A528D263" modified="2000-05-01" version="1">MEVCLARSGFPQCRMTDFRLWEMEGEYTEFAVGAALLAGHATYGVVAALVCAAVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ4</accession>
    <name>HMUV_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemin import ATP-binding protein HmuV</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hmuV</name>
        <name type="ordered locus">SCO2274</name>
        <name type="ORF">SCC75A.20</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50583">
        <property type="entry name" value="T50583"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626522.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028243.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKQ4"/>
    <dbReference type="SMR" id="Q9RKQ4"/>
    <dbReference type="STRING" id="100226.SCO2274"/>
    <dbReference type="GeneID" id="1097707"/>
    <dbReference type="KEGG" id="sco:SCO2274"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2311"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="InParanoid" id="Q9RKQ4"/>
    <dbReference type="OMA" id="RYAWNGL"/>
    <dbReference type="PhylomeDB" id="Q9RKQ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51261">
        <property type="entry name" value="HMUV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000269631" description="Hemin import ATP-binding protein HmuV">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="26"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01718"/>
        </source>
    </evidence>
    <sequence length="280" mass="29121" checksum="6C5F4860186F6CDF" modified="2000-05-01" version="1">MRGVKLPRLVPSRPVPPPPAAPGEVLAAAGGLRVHLGGRPVLDGVDVEVRAGEVLALVGPNGAGKSTLLGALAADVPAAEGVVRVHGRPVSDWSAPELALRRAVLPQSASLSFPFAVEEVVRMGRAPWAGGDRADEDEAAVAEAMARTEVAGFAGRPFSALSGGERARVALARVLAQRAPLLLLDEPTAALDLRHQELVLRLCRERARAGDAVVVVLHDLALAAAYADRVALLRSGRIAAGGPPSEVFAQGLLSEVYDQPVEVFPHPRTGALLVVPHRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL42</accession>
    <name>Q9RL42_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624765.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027121.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0444"/>
    <dbReference type="GeneID" id="1095867"/>
    <dbReference type="KEGG" id="sco:SCO0444"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.421"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133181_0_0_11"/>
    <dbReference type="OMA" id="NAPDLFW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021257">
        <property type="entry name" value="DUF2809"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10990">
        <property type="entry name" value="DUF2809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="13608" checksum="49B9F57ED801C896" modified="2000-05-01" version="1">MVSSSRARVAARDDPGRTRSAAAVSAVLVVGAGLALRALAAGEVAKYGGDALYTLLLFALVFAAAPRTAPAKAAALALAVSWGVEFLQLSDVPAHLARQSTAARLVLGSTFNAPDLFWYAVGAATGWLAVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1P7</accession>
    <name>Q9S1P7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0244</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37159">
        <property type="entry name" value="T37159"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624576.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026953.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095668"/>
    <dbReference type="KEGG" id="sco:SCO0244"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.216"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050510_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S1P7"/>
    <dbReference type="OMA" id="NGHWDVT"/>
    <dbReference type="PhylomeDB" id="Q9S1P7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331858" evidence="2">
        <location>
            <begin position="46"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="3">
        <location>
            <begin position="166"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB53284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="36261" checksum="7A6301078D5C069D" modified="2000-05-01" version="1">MHENPPARRRGRSRREQRRRRRARRRRITWTVTSVVVLIGGAAYAITGTDSGESSAPTRAKAPSSPAVSARAKAGEAPADAEPLPSPTSTLKPFDLEPALAPVTALFGDNRMSVAMLDVESGAMATYGHDAFDTASIVKVDILATLLLQAQDQGRRLTTEERAQSAAMIQKSDNDSTSALWTRIGSARGLDAANERLGLTQTQGGDGTVWGITQTTAEDQIRLLQSVFGDKSPLSEASRAYIQDLMQHVVGSQTWGVSAAADSGTTALKNGWLKRTQTKKWDVNSIGRIQRDGRVYLMAVLLNNCSTQEVGISIVEQATRASAKAFSRKLKEKPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1T6</accession>
    <name>Q9S1T6_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0056</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37120">
        <property type="entry name" value="T37120"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624410.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026812.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0056"/>
    <dbReference type="GeneID" id="1095487"/>
    <dbReference type="KEGG" id="sco:SCO0056"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.46"/>
    <dbReference type="HOGENOM" id="CLU_189130_2_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="29" mass="3254" checksum="C97B50CAB5DA1D11" modified="2000-05-01" version="1">MCRELLAKARLHPIESETDDTVLPTELTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S208</accession>
    <name>3MGH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1792</name>
        <name type="ORF">SCI51.32c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36895">
        <property type="entry name" value="T36895"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626063.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977030.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S208"/>
    <dbReference type="SMR" id="Q9S208"/>
    <dbReference type="STRING" id="100226.SCO1792"/>
    <dbReference type="GeneID" id="1097226"/>
    <dbReference type="KEGG" id="sco:SCO1792"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1813"/>
    <dbReference type="eggNOG" id="COG2094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060471_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S208"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="PhylomeDB" id="Q9S208"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100114" description="Putative 3-methyladenine DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <sequence length="213" mass="23358" checksum="4F99FBC60E0648C0" modified="2000-05-01" version="1">MIASPDRTPLPREFFDRPVLEVAPDLLGRILVRTGPDGPITLRLTEVEAYDGQNDPGSHAYRGRTPRNEVMFGPPGHVYVYFTYGMWFCMNLVCGPEGRSSAVLLRAGEIIDGAELARTRRLSARNDKELAKGPARLATALGVDRALNGTDACTSQETPLRILTGTPVPGDQVRNGPRTGVAGEGGVHPWRYWVADDPTVSPYRAHVPRKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S6T0</accession>
    <name>Q9S6T0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7263</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35345">
        <property type="entry name" value="T35345"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631319.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031550.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S6T0"/>
    <dbReference type="STRING" id="100226.SCO7263"/>
    <dbReference type="CAZy" id="CBM12">
        <property type="family name" value="Carbohydrate-Binding Module Family 12"/>
    </dbReference>
    <dbReference type="CAZy" id="GH19">
        <property type="family name" value="Glycoside Hydrolase Family 19"/>
    </dbReference>
    <dbReference type="GeneID" id="1102701"/>
    <dbReference type="KEGG" id="sco:SCO7263"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7365"/>
    <dbReference type="eggNOG" id="COG3179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045506_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S6T0"/>
    <dbReference type="OMA" id="TISTWYW"/>
    <dbReference type="PhylomeDB" id="Q9S6T0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176987" evidence="3">
        <location>
            <begin position="31"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="36"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="168"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="31829" checksum="7177041C60705579" modified="2000-05-01" version="1">MSRRRISAVVTALALAGAVPLLMPANEASAASCSSYHAWSADANYNTGDIVRYTDGKAYIAEHANPGYDPLISTWYWDPYACDGGSQTPVGNFVVSEAQFNQMFPGRNSFYTYSGLTAALSAYPGFANTGSDTTKKQEAAAFLANVSHETGGLVYIVEQNTANYPHYCDWNQPYGCPAGQAAYYGRGPIQLSWNFNYKAAGDALGIDLLGNPWLVQNDAAVAWKTGLWYWNTQSGPGTMTPHNAMVNGAGFGQTIRSINGSLECDGKNPAQVQSRVTKYQQFAQILGVSPGGNLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX12</accession>
    <name>Q9WX12_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3322</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36270">
        <property type="entry name" value="T36270"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627532.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028909.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3322"/>
    <dbReference type="DNASU" id="1098756"/>
    <dbReference type="GeneID" id="1098756"/>
    <dbReference type="KEGG" id="sco:SCO3322"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3382"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052657_0_1_11"/>
    <dbReference type="InParanoid" id="Q9WX12"/>
    <dbReference type="OMA" id="FGRGLYK"/>
    <dbReference type="PhylomeDB" id="Q9WX12"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="32035" checksum="8EF911086D477F00" modified="1999-11-01" version="1">MLAGEASAEAARKSAEAAETAGTSQETTPGSGVAEPEFPVHGDDRAAAFFDLDNTVMQGAAIFHFGRGLYKRKFFETRDLARFAWQQAWFRLAGFEDPEHMQDARDSALSIVKGHRVSELKSIGEEIYDEYMAERIWPGTRALAQAHLDAGQKVWLVTAAPVEIAQVIARRLGLTGALGTVAESIGGVYTGKLVGEPLHGPAKAEAVRALATAEALDLSRCAAYGDSHNDIPMLSLVGHPYAINPDSKLRKHARELEWRLRDYRTGRKAAKVGIPAAAGVGAVAGGTAAAIALHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Q4</accession>
    <name>Q9X7Q4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl coA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6748</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35273">
        <property type="entry name" value="T35273"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031153.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6748"/>
    <dbReference type="GeneID" id="1102187"/>
    <dbReference type="KEGG" id="sco:SCO6748"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6855"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="InParanoid" id="Q9X7Q4"/>
    <dbReference type="OMA" id="RPPRFTW"/>
    <dbReference type="PhylomeDB" id="Q9X7Q4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="257" mass="26793" checksum="5382E559747B426B" modified="1999-11-01" version="1">MDSIRSMEPQLLHRVADSVATVVVHHPAKRNAMTTAMWRALPGLLDGLAADPGVRALVLTGEGATFCAGADISTLRESAEEAQGLAVRAEEALAAFPRPTLAAIRGHCVGGGAQLAAACDLRFAEETALFGVTPAKLGVVYPASATRRLVALTGPATAKYLLFGGELIDAARALRTGLVDEVLPEGGLGKRVAEFTRVLVSRSLLTQAAAKEFAAGRTDRDAHWAAQARGSGDTAEGVAAFLERRQPRFGWNGPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X872</accession>
    <name>Q9X872_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3516</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36099">
        <property type="entry name" value="T36099"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029052.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3516"/>
    <dbReference type="GeneID" id="1098952"/>
    <dbReference type="KEGG" id="sco:SCO3516"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3574"/>
    <dbReference type="eggNOG" id="ENOG5032I31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145452_0_0_11"/>
    <dbReference type="OMA" id="TRIWQAA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046205">
        <property type="entry name" value="DUF6238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19751">
        <property type="entry name" value="DUF6238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="150" mass="16329" checksum="A5E94AE3DC3D7265" modified="1999-11-01" version="1">MSRTASPTAQDFVPFATAALDFHQALNIPCGPLVTTRAELDALHAHLVSLYGLLDAHAGRTGQLVANEGDQLRTARTRIWQAAEHLHAAYHAAPRPDSSEIPEPEACQAGLPEGAPELTICQRHQRTAHLVRRRTTPADLHAPFTGLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8N7</accession>
    <name>Q9X8N7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO3381</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36392">
        <property type="entry name" value="T36392"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627589.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975452.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3381"/>
    <dbReference type="GeneID" id="1098818"/>
    <dbReference type="KEGG" id="sco:SCO3381"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3444"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8N7"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="PhylomeDB" id="Q9X8N7"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="69"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="160"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB40881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="34165" checksum="27532E0DC566FE1E" modified="1999-11-01" version="1">MNPSDPTELPLASGGGCGDGCACGAETEEEAFMECGLDPALAALLLDSGLDPVEVEDIANVAIQEDLAGGVDVTTVATIPEDAVATADFTAREAGVVAGLRVAEAVLSVVCTDEFEVERHVEDGDRVAEGQKLLSVTTRTRDILTAERSALNLLCRMSGIASATRAWADALDGTKAKVRDTRKTTPGLRGLEKFAVRCGGGVNHRMSLSDAALVKDNHVVAAGGVAEAFNAVRESFPEVPIEVEVDTLHQLREVVDAGADLILLDNFTPDECEEAVALVAGRAALEASGRLTLTNAKAYAATGVDYLAVGALTHSSPILDIGLDLRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Y8</accession>
    <name>Q9X9Y8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1884</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36898">
        <property type="entry name" value="T36898"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976936.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1884"/>
    <dbReference type="GeneID" id="1097318"/>
    <dbReference type="KEGG" id="sco:SCO1884"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1909"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064249_0_0_11"/>
    <dbReference type="OMA" id="TRRDPWF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029475">
        <property type="entry name" value="PmoA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14100">
        <property type="entry name" value="PmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="30540" checksum="A0CBD313D759CCE8" modified="1999-11-01" version="1">MTGNDSPVLRVAGRPVARYVTRPELPHRLSPRPYLHPVATLAGTAVTEFSPADHLHHLGVGVAVPDVEGHNFWGGRTYVRGRGPTELDNHGTQRHTAFQLRDPDGFVEELRWVAAGAELLRERRTVAAAELTGTAWALDFTFSLTNVTRDPLTLGSPATNGRPGAAYGGFFWRARKESTPPGVFTADREGEREVHGRGADWLALTGETWSLVFAGATERTRRDPWFVRTEEYPGVGSSLAHDDRVTVAPGDTLVRRIVTVVADGRLDADGAAALVRKAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA90</accession>
    <name>Q9XA90_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36448">
        <property type="entry name" value="T36448"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625135.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978024.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9XA90"/>
    <dbReference type="STRING" id="100226.SCO0835"/>
    <dbReference type="DNASU" id="1096258"/>
    <dbReference type="GeneID" id="1096258"/>
    <dbReference type="KEGG" id="sco:SCO0835"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.827"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA90"/>
    <dbReference type="OMA" id="ASHGHAW"/>
    <dbReference type="PhylomeDB" id="Q9XA90"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB48912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23055" checksum="C8DD0383A9D00365" modified="1999-11-01" version="1">MTDIPAPAPAAEFWEARYRDTGRVWSGRPNELLVQEAGGLAPGTALDLGCGEGADAVWLASRGWRVTGVDISATALERAAGHADGAGVGDRVLWERHELGPSFPEGSFDLVSAHYLQSPVALDQQAVLRAAARAVAPGGTLLVVMHAGWPSWQTEPPFDAAFPTLDGVLAELALPEGEWSVETRRTARRPSVAPDGTEGFREDHVWRLKRAVFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA91</accession>
    <name>Q9XA91_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0834</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36447">
        <property type="entry name" value="T36447"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625134.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978025.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0834"/>
    <dbReference type="GeneID" id="1096257"/>
    <dbReference type="KEGG" id="sco:SCO0834"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.826"/>
    <dbReference type="eggNOG" id="ENOG5031SZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191589_0_0_11"/>
    <dbReference type="OMA" id="DSRECAA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB48911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="62" mass="6605" checksum="7F6AF8437BE11B00" modified="1999-11-01" version="1">MPSKDKVLEEVTRTENIDIDAALDPAEPDGVFRDSRECAALALQSGGTSLLLSPPTPRPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAB0</accession>
    <name>Q9XAB0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0815</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36428">
        <property type="entry name" value="T36428"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625115.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027371.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0815"/>
    <dbReference type="GeneID" id="1096238"/>
    <dbReference type="KEGG" id="sco:SCO0815"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.807"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_1_1_11"/>
    <dbReference type="InParanoid" id="Q9XAB0"/>
    <dbReference type="OMA" id="NSCLMHI"/>
    <dbReference type="PhylomeDB" id="Q9XAB0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="138"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB48892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="26786" checksum="855C13071B6DFBCD" modified="1999-11-01" version="1">MRVALFLTCVNDTLYPETGRAVVRLLTRLGVEVDFPMAQTCCGQAHYNTGYRQEAEPLARHFADVFAGYDAIVTPSGSCGAMVRELYPRMGERARAEGRGDTLATVLAPVVPKTYELTEFLVDVLGVTDVGAYYPHTVTYHPTCHGLRSLGLGDRPRRLLEAVKGLELVELPGAEECCGFGGTFAVKNSDVSAAMGTDKVRNAESTGADVLCAADNSCLMHIGGTMTRLRTGMRPVHIAEILASTGEAAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAB7</accession>
    <name>6PGL_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>6-phosphogluconolactonase</fullName>
            <shortName>6PGL</shortName>
            <ecNumber>3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pgl</name>
        <name type="synonym">devB</name>
        <name type="ordered locus">SCO1939</name>
        <name type="ORF">SCC22.21</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36011">
        <property type="entry name" value="T36011"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626204.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976879.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAB7"/>
    <dbReference type="SMR" id="Q9XAB7"/>
    <dbReference type="STRING" id="100226.SCO1939"/>
    <dbReference type="GeneID" id="1097373"/>
    <dbReference type="KEGG" id="sco:SCO1939"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1966"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAB7"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="PhylomeDB" id="Q9XAB7"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000090106" description="6-phosphogluconolactonase">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="261" mass="27211" checksum="7FE7741A0295AF91" modified="1999-11-01" version="1">MSDTPQLVVHRDKELMAEAAAARLITKIVDAQASRGSASVVLTGGRNGNGLLAALAGSPARDAIDWSRLDLWWGDERFLPEGDPERNVTQAQQALLDSVPLDPKRVHAMAASDGPYGSDVEAAAAAYAQELATASVPENHAAVPSFDVLLLGVGPDTHVASLFPEHPGVRETERTVIGVHGSPKPPPIRISLTLPAIRAAREVWLLAAGEDKANAVAMALSGAGEIQAPAAGARGRARTLWLLDSAAASQLPRSLYPPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAF4</accession>
    <name>Q9XAF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35624">
        <property type="entry name" value="T35624"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629447.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030164.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5305"/>
    <dbReference type="GeneID" id="1100745"/>
    <dbReference type="KEGG" id="sco:SCO5305"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5391"/>
    <dbReference type="eggNOG" id="ENOG5033USA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091365_0_0_11"/>
    <dbReference type="OMA" id="EYRLQWT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177044" evidence="2">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="28441" checksum="A31F93A852D10828" modified="1999-11-01" version="1">MLPSRRGRPARVPAALALLLATAATGVLAACGDTGGLESAGATPAAHHPARLWPGLTPASSPAYDIGEVEHAPMKGVAVPGGDIRRADPVAAVRAEIAAHPDDYAGAGARYHETSARMADCGADGAGDEPGGCPVLRPYYRDLTGDGRPEMTLGFRLLPDRLTAVRVYTVEKDRLVRIMSYEDAVSAVELAGRTVIVRSPSEVAGYEYRLQWTWDADQRAMLLTSDEMLRTDDGGRHARRPSASPSPSVSRSAAPPSSPPAAPSASPSASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI1</accession>
    <name>Q9XAI1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3621</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35389">
        <property type="entry name" value="T35389"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627816.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029122.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3621"/>
    <dbReference type="GeneID" id="1099057"/>
    <dbReference type="KEGG" id="sco:SCO3621"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3679"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_135_1_11"/>
    <dbReference type="InParanoid" id="Q9XAI1"/>
    <dbReference type="OMA" id="MFRIAQE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB45488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="783" mass="75647" checksum="9C7F3A7614B5E8A5" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z511</accession>
    <name>Q9Z511_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1954</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36027">
        <property type="entry name" value="T36027"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626218.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976865.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1954"/>
    <dbReference type="GeneID" id="1097388"/>
    <dbReference type="KEGG" id="sco:SCO1954"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1980"/>
    <dbReference type="eggNOG" id="ENOG50309MX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055999_0_0_11"/>
    <dbReference type="OMA" id="YWQQGAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB38144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34815" checksum="2A9CC79BF4819472" modified="1999-05-01" version="1">MPHATQHADVATAQLDSALRGGPFHVALRAAIAARGLPLQRVQHHLSRHGVKVGVTSLSYWQQGARRPQRPESLRAVRALEEILQLPEESLIRLLAEADSEPEERRPAGRSYRAHLAASGVLDQLLTELGYPSPDGGVHTLGHHERIRIGPRRELAGRESHLIVRAHRDGVDRFVAVHYGDPGCVPARMTVHALENCRTGRVRTHQETGVLVTELLFDTRLGAGDTHLFRYGVEDATAGVSREYVRGFGTAGGQYALQVRFDAAALPVRCHRFTQHSPAAPRGGRQELVLSGQHHSVHLVEPRVRSGMLGIGWDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBG9</accession>
    <name>Q9ZBG9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gamma-glutamyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35931">
        <property type="entry name" value="T35931"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630529.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030924.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9ZBG9"/>
    <dbReference type="STRING" id="100226.SCO6444"/>
    <dbReference type="MEROPS" id="T03.014"/>
    <dbReference type="GeneID" id="1101883"/>
    <dbReference type="KEGG" id="sco:SCO6444"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6544"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_3_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBG9"/>
    <dbReference type="OMA" id="GCKLAMA"/>
    <dbReference type="PhylomeDB" id="Q9ZBG9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="647" mass="68375" checksum="C15174FD12E26E0B" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ8</accession>
    <name>RL321_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L32-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmF1</name>
        <name type="synonym">rpmF</name>
        <name type="ordered locus">SCO5571</name>
        <name type="ORF">SC7A1.15</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35655">
        <property type="entry name" value="T35655"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629706.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006139588.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBQ8"/>
    <dbReference type="SMR" id="Q9ZBQ8"/>
    <dbReference type="STRING" id="100226.SCO5571"/>
    <dbReference type="GeneID" id="1101012"/>
    <dbReference type="KEGG" id="sco:SCO5571"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5660"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ8"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="PhylomeDB" id="Q9ZBQ8"/>
    <dbReference type="PRO" id="PR:Q9ZBQ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000172412" description="50S ribosomal protein L32-1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="57" mass="6573" checksum="5D6A4327DE490FDF" modified="2007-01-23" version="3">MAVPKRKMSRSNTRHRRSQWKAAVPTLVACERCHEPKLQHIACPACGTYNKRQVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBU9</accession>
    <name>Q9ZBU9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6139</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34652">
        <property type="entry name" value="T34652"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630244.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972783.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6139"/>
    <dbReference type="GeneID" id="1101580"/>
    <dbReference type="KEGG" id="sco:SCO6139"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6243"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBU9"/>
    <dbReference type="OMA" id="LKYAHGS"/>
    <dbReference type="PhylomeDB" id="Q9ZBU9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="184"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="41430" checksum="7F24D276808233DC" modified="1999-05-01" version="1">MIDRRRVLELWRRLDVTVRDLPLGVLLLVASLLPSLRGQGTEIGGLPTRPADALAGVAAVLQSIPLAVRRRWTLLCLTLVSLGFALDQLRAYHLFAGAALPIVLINAGSHQEKYRRATQVTATLGYVAMAVGLNARGGDETLVEYVTFYLVLALAWGIGAWMRSARAAEAERRSRVAEDARNAERTRIARELHDVVTHHVTAMVVQSEAARYLTAAPERLDESLAAVSDTGRRAITDLRHLLDLLNPDHGTAEPRTPPVGRVLTLVEQTRRAGQPVEFTEEGTPAAATGSSDLVAYRVVQEALTNALKYDHGGRTSVLVRHGEREITVEVGTDGSGSGAASPGGSGRGLAGLRERVDVLGGEFSTDRPADGGFVVRARIPGGSGGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBV8</accession>
    <name>Q9ZBV8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative respiratory chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO6560</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35002">
        <property type="entry name" value="T35002"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630641.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031007.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6560"/>
    <dbReference type="GeneID" id="1101999"/>
    <dbReference type="KEGG" id="sco:SCO6560"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6664"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBV8"/>
    <dbReference type="OMA" id="DRMLMEG"/>
    <dbReference type="PhylomeDB" id="Q9ZBV8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="562"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAA22364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="646" mass="67959" checksum="C29B5E6F46F3C45A" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O50506</accession>
    <name>O50506_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted chitinase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6012</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA15789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35677">
        <property type="entry name" value="T35677"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630126.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030596.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6012"/>
    <dbReference type="CAZy" id="CBM5">
        <property type="family name" value="Carbohydrate-Binding Module Family 5"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="1101454"/>
    <dbReference type="KEGG" id="sco:SCO6012"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6110"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019399_3_0_11"/>
    <dbReference type="InParanoid" id="O50506"/>
    <dbReference type="OMA" id="ATTVYNW"/>
    <dbReference type="PhylomeDB" id="O50506"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174828" evidence="2">
        <location>
            <begin position="34"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="40"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA15789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="52681" checksum="5EAD34A9874C6A73" modified="1998-06-01" version="1">MRRMRSIRAALTAAATTVAAVGLALSGTGPAQAATPLPDRVFAPYFEAWTGESPAALAAQSGAKHLTMAFLQTATPGSCTPYWNGDTSMPIAQSTFGADFDTIQANGGDVIPSFGGYTADTTGTEIADSCTDVQQIAAAYEKVITTYDVSRLDMDIEIDALDNTAGIDRRNKAIKLVQDWAAANGRDLEISYTLPTTTRGLASNGVALLENAVKNGTKVDVVNLMTFDYYDNQQHDMARDTQTATQGLHDVLARLHPGKSSADLWHMIGVIEMIGVDDFGPAETFTLDNARTVYDWALDQGINTLSFWALQRDNGSCAGGGAADNCSGIQQNTWDFSHVFAPFTSGSTAPENDFSLSATPASGTVTAGASATTTVKTAVKSGTAQTVQLGASGVPAGVTASFSPASVTAGGQSTLTLATTGQAVSGTYSITVTGTGPSGSHSTTYALTVTGGNGNQCTAVPWNSGAIYTGGQQVSHEGHTWKAKWWTTGEEPGTTGQWGVWQDLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O50511</accession>
    <name>O50511_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5837</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35873">
        <property type="entry name" value="T35873"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629960.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973184.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5837"/>
    <dbReference type="GeneID" id="1101279"/>
    <dbReference type="KEGG" id="sco:SCO5837"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5934"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_1_11"/>
    <dbReference type="InParanoid" id="O50511"/>
    <dbReference type="OMA" id="YDVGSRH"/>
    <dbReference type="PhylomeDB" id="O50511"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="187"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="450" mass="49046" checksum="976D90CBBD7F90F5" modified="1998-06-01" version="1">MPMGHTATAQAGSGGLTATEHRLANGLRVVLSEDHLTPVAAVCLWYDVGSRHEVKGRTGLAHLFEHLMFQGSAQVKGNGHFELVQGAGGSLNGTTSFERTNYFETMPAHQLELALWLEADRMGSLLAALDDESMENQRDVVKNERRQRYDNVPYGTAFEKLTALAYPEGHPYHHTPIGSMADLDAATLEDARAFFRTYYAPNNAVLSVVGDIDPEQTLAWIEKYFGSIASHDGKQPPRDGALPDVMGGELREVVEEEVPARALMAAYRLPEDGTRACDAADLALTVLGGGESSRLYNRLVRRDRTAVAAGFGLLRLAGAPSLGWLDVKTSGDVEVPVIETAIDEELARFADEGPTAEEMERAQAQLEREWLDRLGTVAGRADELCRYAVLFGDPQLALTAVQRVLEVTAEEVQEVAKARLRPDNRAVLVYEPTASADETDASDENEEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O54095</accession>
    <name>O54095_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5897</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34570">
        <property type="entry name" value="T34570"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630017.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030519.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="SMR" id="O54095"/>
    <dbReference type="STRING" id="100226.SCO5897"/>
    <dbReference type="GeneID" id="1101339"/>
    <dbReference type="KEGG" id="sco:SCO5897"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5996"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_1_1_11"/>
    <dbReference type="InParanoid" id="O54095"/>
    <dbReference type="OMA" id="ENLMDMY"/>
    <dbReference type="PhylomeDB" id="O54095"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047086">
        <property type="term" value="F:ketosteroid monooxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="395" mass="44922" checksum="8926278E3D73CD2A" modified="1998-06-01" version="1">MIPNQWYPIVEAQEVGNDKPLGVRRMGQDLVLWRDIDGNLVCQGARCPHKGANLGDGRMKGNTIECPYHGFRYGADGACRVIPAMGSEARIPGSLRVPTYPVREQFGLVWMWWGDERPTADLPPVAAPAEVTDNRKLYATKRWTRPVHYTRYIESLLEFYHVTYVHRDHWFNYIDYLLLYGTPSKFGLDGRERYLAATRITNHRVETEAEGQTIRYSFDHCQEDDPTNTTHYVITFTFPCMVHVQTEQFETTSWLVPIDDQNTEHILRWYEYEQVKPVLRFEPLRRLLPWASLYMEKWVQDPQDVRIMEHQEPKISAGGVNKFIPVDEMNAKYISMRAKLIADASAAPSSPARAAEPEPEAAGRGGSAARATGNGRGAAGGRRGTKPKEDAAARP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O69913</accession>
    <name>PYRH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="ordered locus">SCO5626</name>
        <name type="ORF">SC2E1.43</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34811">
        <property type="entry name" value="T34811"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629760.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973384.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O69913"/>
    <dbReference type="SMR" id="O69913"/>
    <dbReference type="STRING" id="100226.SCO5626"/>
    <dbReference type="PRIDE" id="O69913"/>
    <dbReference type="GeneID" id="1101067"/>
    <dbReference type="KEGG" id="sco:SCO5626"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5715"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_11"/>
    <dbReference type="InParanoid" id="O69913"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="PhylomeDB" id="O69913"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000143891" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="1">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="253" mass="26834" checksum="71F57C40E8ACE1EA" modified="1998-08-01" version="1">MSSTKAEKSDDGKVSGRFMLKLSGEAFSGGGGLGVDPDVVHAIAREIAAVVRDGAQIAIVIGGGNFFRGAELQVRGMDRARSDYMGMLGTVMNCLALQDFLEKEGVDCRVQTAITMGQVAEPYIPLRAVRHLEKGRVVIFGAGMGMPYFSTDTTAAQRALEIDAEALLMGKNGVDGVYDSDPKTNPDAVKFDALGYGEVITRDLKVADATAVTLCRDNSLPIVVFELLKEGNIARAVKGEKIGTLVGDQGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O69937</accession>
    <name>O69937_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">SCO6409</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34903">
        <property type="entry name" value="T34903"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630496.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972570.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6409"/>
    <dbReference type="GeneID" id="1101848"/>
    <dbReference type="KEGG" id="sco:SCO6409"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6509"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_11"/>
    <dbReference type="InParanoid" id="O69937"/>
    <dbReference type="OMA" id="SAPEFCY"/>
    <dbReference type="PhylomeDB" id="O69937"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA19620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="26714" checksum="09C5F7A267DC65F7" modified="1998-08-01" version="1">MVELKTDTSIDAMHAAGQVVARALTAVRQAADVGVSLLELDAVAHEVLREAGAGSPFLGYRPSFAPTPFPGVICASVNDAIVHGIPDGYRLRDGDLVSIDCGALLDGWAGDSALSFVVGTPRPADVTLIETAERALEAGIAAAVVGNRIGDIAHAIGTVCRSAGYGIMEDFGGHGIGRHMHEDPGVPNEGRPGRGLPLRHGMVLAIEPMLTAGGRDDYHAAPDGWTLRTNDGSRAAHVEHTVAITDGGPRVLTSRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O86524</accession>
    <name>O86524_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5543</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29073">
        <property type="entry name" value="T29073"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629677.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973453.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5543"/>
    <dbReference type="GeneID" id="1100983"/>
    <dbReference type="KEGG" id="sco:SCO5543"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5631"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_0_1_11"/>
    <dbReference type="InParanoid" id="O86524"/>
    <dbReference type="OMA" id="HPDCDIG"/>
    <dbReference type="PhylomeDB" id="O86524"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14328" checksum="9DB8A6634CCF7696" modified="1998-11-01" version="1">MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLAMSEGFPRDRADQLAAVASGLTSLTAGASRIFEGGNVAQTVVEMERGFLFLMSVSDGSSLAVLAHPECDIGLVGYEMALLVDRAGAVLTPDLRAELQGSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>O86612</accession>
    <name>O86612_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6343</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29429">
        <property type="entry name" value="T29429"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630435.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030842.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6343"/>
    <dbReference type="GeneID" id="1101784"/>
    <dbReference type="KEGG" id="sco:SCO6343"/>
    <dbReference type="HOGENOM" id="CLU_3258237_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="42" mass="4669" checksum="7D89C74FE1446253" modified="1998-11-01" version="1">MTERCVSAALVMFVSIRCSGRRDMNARGTYVGCSRRSLLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O88024</accession>
    <name>O88024_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative two-component sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35167">
        <property type="entry name" value="T35167"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031091.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6668"/>
    <dbReference type="GeneID" id="1102107"/>
    <dbReference type="KEGG" id="sco:SCO6668"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6774"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="O88024"/>
    <dbReference type="OMA" id="HAVSLMI"/>
    <dbReference type="PhylomeDB" id="O88024"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="304"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="405" mass="42622" checksum="BC380A7504649843" modified="1998-11-01" version="1">MSARSPLSSPLAPVLARLRTASPYAVDAAVAALVLFAVSLQWLFPDEGDDPLSWRGWLLGAGTAVPLVWRRAAPFATACAVSVATPAQAVHHAPPPDLMYGGFVVLYTLAALARPWQRRVMLAGWLAGVAATISHKEDAEPFEYAFQLLSIVCAYALGSLTRTQRAYTAELEDRARHLERERAADTARATAQERARIARDMHDILAHAVSLMVVQAEAGPVVVRSDPARAEAAFDAIATAGRDAMTQLRRILGVLKEEEREPGPRRLPQPGLTALPGLVRRVGESAGLRVELRTTGEPGALPPDTEAAAYRIVQEALTNTVKHAYASCAVVGLDWAEDGVTLTVTDDGRGPAPGDGTGGGGHGLIGIRERAAACGGEAVTGGGPDGGFRVVVRLPAAAVRRTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKM3</accession>
    <name>Q7AKM3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3226</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36318">
        <property type="entry name" value="T36318"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627440.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028838.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3226"/>
    <dbReference type="GeneID" id="1098660"/>
    <dbReference type="KEGG" id="sco:SCO3226"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3289"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q7AKM3"/>
    <dbReference type="OMA" id="AIIAHES"/>
    <dbReference type="PhylomeDB" id="Q7AKM3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24047" checksum="B7551A74F79BBFA7" modified="2012-05-16" version="1">MIRVLLADDETIIRAGVRSILTTEPGIEVVAEASDGREAVELARKHRPDVALLDIRMPEMDGLTAAGEMRTTNPDTAVVVLTTFGEDRYIERALDQGVAGFLLKASDPRDLISGVRAVASGGSCLSPLVARRLMTELRRAPSPRSEVSGERTTLLTKREQEVLGMLGAGLSNAEIAQRLHLVEGTIKTYVSAIFTQLEVRNRVQAAIIAYEAGLVKDADLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API6</accession>
    <name>Q7API6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mmyQ</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639839.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039531.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095312"/>
    <dbReference type="KEGG" id="sco:SCP1.231"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8176"/>
    <dbReference type="HOGENOM" id="CLU_076368_2_1_11"/>
    <dbReference type="InParanoid" id="Q7API6"/>
    <dbReference type="OMA" id="RAFTHIM"/>
    <dbReference type="PhylomeDB" id="Q7API6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="22856" checksum="D25CC02FE90A2BF4" modified="2012-05-16" version="1">MTNTSTSLRIGVLGAGNIGRPIGRHWAVAGHEVAFGSRTPDQLTEFAGALRPAARATTLAEAVETSDVLLLSVPYSAWDDLLQAVGDRLAGKLVIDATNPMGLSEEGRIISTLDQGITQGRNSAKLLPEATVVRAFTHIMDELLWSRGTQQKHFWGMAYAGDDVDAKEVVARLIHDAGFSPVDLGGLDDSAALDPGGAIFPHMFTPADLRAAAGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJM3</accession>
    <name>Q8CJM3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6604</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAD55382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29111">
        <property type="entry name" value="T29111"/>
    </dbReference>
    <dbReference type="PIR" id="T35792">
        <property type="entry name" value="T35792"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733708.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972374.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q8CJM3"/>
    <dbReference type="STRING" id="100226.SCO6604"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102043"/>
    <dbReference type="KEGG" id="sco:SCO6604"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6711"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_11"/>
    <dbReference type="InParanoid" id="Q8CJM3"/>
    <dbReference type="OMA" id="NRWWLDP"/>
    <dbReference type="PhylomeDB" id="Q8CJM3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="423"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="468" mass="51660" checksum="215964C4FEE584FF" modified="2003-03-01" version="1">MTGTPQRSHPQPERTFVTIDFAALPDDFLWGTATSAYQIEGAVAEDGRSPSIWDTFSHTPGKIDNGDHGDVACDHYHRTHEDIELMRRLGTNAYRLSVAWPRVVPGGDGPVNAKGLAFYDRLVDDLLAAGITPSVTLYHWDLPQVLQDRGGWPERDTAEHFAAYAAVVAERLGDRVAHWATLNEPLCSAWIGHLEGKMAPGQTDLTAAVRASYHLLLGHGLAMQAIRAAAPDAQVGIVNNLSTIHAATDREEDLAAARRMDGHTNRWWLDPVHGRGFPQDMREVYGVELPERPGDMRLIGAELDWLGLNYYFPQTVAADPTGPAPQVRTVRRAGVPRTGMDWEIDAGGIEELLLRLTEEYGPRKLYVTENGSSFPDLVRPDGSVDDPERQEYLTAHLAACASAARKGAPLAGYFAWSLLDNFEWAYGYDKRFGLVHVDYATQVRTIKGSGHHYADIIGRARGRERKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-04-07" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK10</accession>
    <name>Q8CK10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1987</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35732">
        <property type="entry name" value="T35732"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733554.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028080.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1987"/>
    <dbReference type="GeneID" id="1097421"/>
    <dbReference type="KEGG" id="sco:SCO1987"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2014"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_0_11"/>
    <dbReference type="InParanoid" id="Q8CK10"/>
    <dbReference type="OMA" id="AGACPLN"/>
    <dbReference type="PhylomeDB" id="Q8CK10"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD55289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="17019" checksum="A80853D3B85D41E4" modified="2003-03-01" version="1">MPAASEIRVRGAAGERTIGRLPARLPGVHVIQRVTVPVLFPPPVYSHASVVEAGTRLAFLAGSVPLDAAGKLVGEGDPVRQAEQVLANLTEQLRAVGSGLEHVLSTDVYVVSAETAALSAVWDVVEASGLSTGPHSSTLLGVSCLGYPGQLVEITATAVVPESGRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-25" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK51</accession>
    <name>PHK_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable phosphoketolase</fullName>
            <ecNumber evidence="1">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO0617</name>
        <name type="ORF">SCF55.41c</name>
        <name type="ORF">SCF56.01c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XFP family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAD55268" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAD55268.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733508.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027249.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8CK51"/>
    <dbReference type="SMR" id="Q8CK51"/>
    <dbReference type="STRING" id="100226.SCO0617"/>
    <dbReference type="GeneID" id="1096040"/>
    <dbReference type="KEGG" id="sco:SCO0617"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.598"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_11"/>
    <dbReference type="InParanoid" id="Q8CK51"/>
    <dbReference type="PhylomeDB" id="Q8CK51"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="chain" id="PRO_0000193891" description="Probable phosphoketolase">
        <location>
            <begin position="1"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="796" mass="88176" checksum="6B2150B492BC02B3" modified="2005-03-15" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK55</accession>
    <name>Q8CK55_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2006" name="FEBS J." volume="273" first="4889" last="4900">
            <title>Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences from plant enzymes.</title>
            <authorList>
                <person name="Hoell I.A."/>
                <person name="Dalhus B."/>
                <person name="Heggset E.B."/>
                <person name="Aspmo S.I."/>
                <person name="Eijsink V.G."/>
            </authorList>
            <dbReference type="PubMed" id="17010167"/>
            <dbReference type="DOI" id="10.1111/J.1742-4658.2006.05487.X"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 41-244</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAD55444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733504.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027151.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="PDB" id="2CJL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A/B=41-244"/>
    </dbReference>
    <dbReference type="PDBsum" id="2CJL"/>
    <dbReference type="SMR" id="Q8CK55"/>
    <dbReference type="STRING" id="100226.SCO0482"/>
    <dbReference type="CAZy" id="GH19">
        <property type="family name" value="Glycoside Hydrolase Family 19"/>
    </dbReference>
    <dbReference type="GeneID" id="1095905"/>
    <dbReference type="KEGG" id="sco:SCO0482"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.461"/>
    <dbReference type="eggNOG" id="COG3179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045506_4_1_11"/>
    <dbReference type="InParanoid" id="Q8CK55"/>
    <dbReference type="OMA" id="NNRVAYY"/>
    <dbReference type="PhylomeDB" id="Q8CK55"/>
    <dbReference type="EvolutionaryTrace" id="Q8CK55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176142" evidence="3">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="4">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2 7">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2 7">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="2CJL"/>
        </source>
    </evidence>
    <sequence length="244" mass="25962" checksum="C09BCEBD579E7A59" modified="2003-03-01" version="1">MQHRKLALLAATGAAAALCTLTMAPSAVAEKSDTRTAAAEFVVSEAQFDQMFPSRNSFYTYSGLTAALSAYPGFSNTGSDTVKKQEAAAFLANVGHETGGLVYVVEQNTANYPHYCDASQPYGCPAGNDKYYGRGPVQLSWNFNYKAAGDALGIDLLNNPDLVQNDSAVAWKTGLWYWNTQTGPGTMTPHDAMVNGAGFGETIRSINGSLECDGGNPGQVQSRIDNYERFTQLLGVEPGGNLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK62</accession>
    <name>Q8CK62_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar ABC-transporter integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0292</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAD55434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36480">
        <property type="entry name" value="T36480"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733497.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026994.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0292"/>
    <dbReference type="GeneID" id="1095716"/>
    <dbReference type="KEGG" id="sco:SCO0292"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.265"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="InParanoid" id="Q8CK62"/>
    <dbReference type="OMA" id="SFMAAYA"/>
    <dbReference type="PhylomeDB" id="Q8CK62"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="33004" checksum="93E1E8D5A550BB55" modified="2003-03-01" version="1">MTTTLPEARRPPGTSPRDRQRRSSRPARRRNWVGGLAGWLWLVVVAVPLYWTLITSLKAQSHYYASNPLVPPGDPTLDNYRLVVESDFLRYFLNSVVVTAGAVVPAVVCSFMAAYAIVRGRHLQVLRAMNGLFLMGLAIPLQATVIPVYLIIIKLQLYDSLPALILPSIAFAVPLSVLVLANFVRDVPKELFDSMRVDGATEWTTMWRLAAPLTRPAILTVTIFNALTIWNGFLLPLVLTQSPERRTLPLALWTFQGQYGVNVPAVLAAVVLTTLPVLILYAFGRRQLLSGLTAGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J62</accession>
    <name>Q93J62_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0982</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625278.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027491.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0982"/>
    <dbReference type="GeneID" id="1096405"/>
    <dbReference type="KEGG" id="sco:SCO0982"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.980"/>
    <dbReference type="eggNOG" id="COG2224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_0_11"/>
    <dbReference type="InParanoid" id="Q93J62"/>
    <dbReference type="OMA" id="LEKDWAE"/>
    <dbReference type="PhylomeDB" id="Q93J62"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="311"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC44332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="426" mass="46550" checksum="6238628104CD1975" modified="2001-12-01" version="1">MAEARTQAAEDLARRWDTEPRWQGIERTYSAQDVVRLSGSVREEHTLARRGAERLWRQLHERDYVHALGALTGGQAVQQIKAGLQAIYLSGWQVAADANQAGHTYPDQSLYPANSVPQVVRRINNALLRADQIATSEGDNSTDWLAPIVADAEAGFGGPLNAFELAKAMIAAGAAGIHYEDQLASEKKCGHLGGKVLVPTSQHIRTLNAARLAADIADTPTVIIARTDALAANLLTSDVDERDAQFVTGERTPEGFYRVRNGMAPVIARGLAYAPYADLIWVETGTPDLEQAREFAEAIHAEHPDQMLAYNCSPSFNWKAALDDDQIAKFQRELGAMGYKFQFITLAGFHSLNHGMFDLARGYAEHGMTAYVDLQEREFAAQAHGFTAVKHQREVGTGYFDLVSTAVNPASSTTALAGSTEEEQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JD3</accession>
    <name>Q93JD3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane cytochrome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5994</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630110.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030587.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5994"/>
    <dbReference type="GeneID" id="1101436"/>
    <dbReference type="KEGG" id="sco:SCO5994"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6093"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_3_0_11"/>
    <dbReference type="InParanoid" id="Q93JD3"/>
    <dbReference type="OMA" id="PCCVSVM"/>
    <dbReference type="PhylomeDB" id="Q93JD3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="31124" checksum="8FC3A0B9E7AA6733" modified="2001-12-01" version="1">MSEAGLAMAFLGGLLALLSPCSALLLPAFFAYSFTSRTRLMARTGLFYVGLCTTLVPLGVAGSFASRLFYGHRDTLVTAGGWTVIALGVAQIVGLGFGSRRMARAAGGRRSGSALSVFALGAVYGLAGFCAGPILGSVLTVAAVDGDPLHGGVLLAVYSLGMAVPMFVLALLWDRFDLGRRRWLRGRTFRAGPLTLHSTTLLGGLFFIALGVAFLAFDGTSALPSVLSTDTEFALEERLSDIGAAVSDRVVLLVLAGAAALTALLVLLRPGGRREAQEPPEPADSGPGEGDSATRSRMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADJ7</accession>
    <name>Q9ADJ7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7462</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971680.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7462"/>
    <dbReference type="GeneID" id="1102900"/>
    <dbReference type="KEGG" id="sco:SCO7462"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7573"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_7_0_11"/>
    <dbReference type="InParanoid" id="Q9ADJ7"/>
    <dbReference type="OMA" id="KELKGHW"/>
    <dbReference type="PhylomeDB" id="Q9ADJ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="26118" checksum="7AF40D95AB68658B" modified="2001-06-01" version="1">MTPEAMAAVFAAGVGAGAINSVVGSGTLITFPVLLATGLPPVTATVSNALGLIPGSISGAIGYRRELRGQRGRVLKFGSGALLGGLAGATLLLTLPADAFETVVPVLVGLALLLVAFQPQIGRLVQRRRARTGTSPRRDGGPLLLTGLTLASVYGGYFTAAQGIIYLSLMGMLLDEPLQRLNGVKNVLSAVVNTVAALFFLFAADFEWTAVGLLAVGSGLGGYVGAKVGRHFSPTVLRILVVTVGTVALVQLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK42</accession>
    <name>Q9AK42_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4884</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629037.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029926.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9AK42"/>
    <dbReference type="STRING" id="100226.SCO4884"/>
    <dbReference type="GeneID" id="1100325"/>
    <dbReference type="KEGG" id="sco:SCO4884"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4964"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AK42"/>
    <dbReference type="OMA" id="LASMMKR"/>
    <dbReference type="PhylomeDB" id="Q9AK42"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176627" evidence="3">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="45"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="347" mass="35708" checksum="25BFAECCEF73273B" modified="2001-06-01" version="1">MRRTSRLIRVAVGVASLALAATACGGTSGESGDDGGDDKGLAIAYDVGGKGDQSFNDAAYAGLERAKKEFGYKTADIEPTDGETDADKEQRLTSLAKQGYNPVIGVGFAYGPAMKAVAAKYPDTTFGIVDSVVEGKNVASLVFAENEASYLAGVVAAKATKSKTVGFVGGVDVPLIHKFQAGYEQGVKDTDPKVKVVSQYLTQTAEEGGFSSPDKGKAAAEGQIEKKADVVYAAAGLSGQGVIEAAAKAKIWAIGVDSDQYKQEALATYKDSILTSALKDINGAVFALAKSVEDGKPLTGTHTFDLKSDGVGLSDSNPKFAEVPGAEEAVEKAKAGIVDGSIKVATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK53</accession>
    <name>Q9AK53_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4064</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628246.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1099500"/>
    <dbReference type="KEGG" id="sco:SCO4064"/>
    <dbReference type="HOGENOM" id="CLU_2481868_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="87" mass="9471" checksum="622A5041A8299AA0" modified="2001-06-01" version="1">MERRIPPRFIPEYGNPNEDISTPPRRDCGPNGMGSLAVSRGHQRNRCRCADRSRASIISPDVLSALPYCTTDLGSSSTLRSHSLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWI4</accession>
    <name>Q9EWI4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7600</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631642.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031771.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9EWI4"/>
    <dbReference type="STRING" id="100226.SCO7600"/>
    <dbReference type="GeneID" id="1103038"/>
    <dbReference type="KEGG" id="sco:SCO7600"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7715"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_0_2_11"/>
    <dbReference type="InParanoid" id="Q9EWI4"/>
    <dbReference type="OMA" id="WVEVWNH"/>
    <dbReference type="PhylomeDB" id="Q9EWI4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="45942" checksum="FC178C3A5FD000C2" modified="2001-03-01" version="1">MDTEHVLRTFVEYYEDQGHRRITGSTLLPEPGDPVLFTSAGMHPLTPYLEGRPHPLGRRLVNVQRCLRTTDLDEVGDSTHLTVFEMLGTWSLGDYEGSRSLDWAHRLLTEGLGVDPGLLHATVYGGGEQVGPDTESLRLWQERGVPVERTVDDNWWSNGPVGPCGPDSEIFLWSGDTPPRSTPTGDDRWVEVWNHVMMRHRRLDDGRLVPLPQRNVDTGLGLERLAMLLQGKSSVFECDVFEPWRRLLPVLWPLDEPSFRVVCDHLRSAVVIVGDGVRPSNTGRGYVLRRLVRRLLTVLWRDDPSRGLGDLPDELITHTLDHFRQDGDPGLPGLVRRLLVEEERRFRRLLDRGRNVLARPRFRGPLGEEDFHYLHDTHGLPRELVTSLREGEYPETEGVGAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX01</accession>
    <name>Q9EX01_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625418.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027591.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1125"/>
    <dbReference type="GeneID" id="1096548"/>
    <dbReference type="KEGG" id="sco:SCO1125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1122"/>
    <dbReference type="eggNOG" id="COG5502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121888_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EX01"/>
    <dbReference type="OMA" id="DANYHAQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="19031" checksum="8456745129370D2A" modified="2001-03-01" version="1">MRERREHGGGARRESEGKRGGVHARFPERTQGTRPGREPAQGGDAVRLDEFLTRVRDRGEFHGDDEAEQVATAVLWVVASRIPPDEAADLARDLPAPLDDALRPERGRPETFGREEFLRRVAQQTGARPRTAEWDAGAVLSTLAEAVPRERVDRLLACLPADCADLFGGPAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX26</accession>
    <name>Q9EX26_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ordered locus">SCO1014</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625310.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027519.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1014"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:lipoprotein biosynthetic process"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC14382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="537" mass="56524" checksum="3976CCE994614B38" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2N6</accession>
    <name>Q9F2N6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3114</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC09555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC09555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="33113" checksum="F438E28940586B58" modified="2001-03-01" version="1">MSGASASPHGFATVRGRERGYRPEQVEACAAALSEERDAAWERAARLTVLAREMEEDLGDLEEVVAQLTSQDYEVLGERARELFRLGEEEAAAVRERARGAARELAEEARAYADGVREAARAHADAVRAEADERARQLLLAARAEADEARIGARRDVKEGRAEALSALREMRRRTAATAAEQSRELAERWAAAERAEEERARALDAHHAELLARAEQGVREAEQELADAGEAAVRRQEEARDRAAEVVAEARARRERIARDTERVLREHGERWDELQAHMASVRSSLQALTGRAVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2U8</accession>
    <name>Q9F2U8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4613</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029763.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4613"/>
    <dbReference type="GeneID" id="1100053"/>
    <dbReference type="KEGG" id="sco:SCO4613"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4685"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160040_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F2U8"/>
    <dbReference type="OMA" id="GPTWIAA"/>
    <dbReference type="PhylomeDB" id="Q9F2U8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC08266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="88" mass="9260" checksum="7C8074060490B792" modified="2001-03-01" version="1">MTVISWIILGLLAGAIAKFLLPGRDPGGLIGTTLIGIAGAFLGGWISARWMDHPISKDFYDGATWAAAIGGSLVLLVAYRLLFGNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3D8</accession>
    <name>Q9F3D8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7619</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631660.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971525.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7619"/>
    <dbReference type="GeneID" id="1103057"/>
    <dbReference type="KEGG" id="sco:SCO7619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7737"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="InParanoid" id="Q9F3D8"/>
    <dbReference type="OMA" id="VYSFHDS"/>
    <dbReference type="PhylomeDB" id="Q9F3D8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="134" mass="14386" checksum="C0AD22BD09649B73" modified="2001-03-01" version="1">MSEQGVAGPYGQVGCHVANGWTVVRADDEIDIAFAPLVRAEVGRRLAEGHRHFVLDLCDTPFIDSMGLGMIVAVTKLIRTHHGSLRIACPDRRLLHVFALGGLGAVYSFHDSVDKAVAQPPGAEGLAGWPYARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBY5</accession>
    <name>Q9FBY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7197</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631255.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031501.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7197"/>
    <dbReference type="GeneID" id="1102635"/>
    <dbReference type="KEGG" id="sco:SCO7197"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7297"/>
    <dbReference type="eggNOG" id="COG1115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024867_1_1_11"/>
    <dbReference type="InParanoid" id="Q9FBY5"/>
    <dbReference type="OMA" id="GMATKFV"/>
    <dbReference type="PhylomeDB" id="Q9FBY5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC01597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="512" mass="53838" checksum="15042F6B2BBC29BA" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3R0</accession>
    <name>Q9K3R0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1088</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625382.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977742.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1088"/>
    <dbReference type="GeneID" id="1096511"/>
    <dbReference type="KEGG" id="sco:SCO1088"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1085"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097939_0_0_11"/>
    <dbReference type="OMA" id="VHLVGGW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="28583" checksum="8E5B7C8C0FAABE82" modified="2000-10-01" version="1">MSDGDGTHEHARQTQAQQAREARTMGNGALDGAVIAVAGAGGPAGRAALLRLAEAGATVVGADNDPERLAEAVDAARYAHGGATVTGETVDLLDLDSTRAWADRTEKEFGHVDGVVHLVGGWRGSKTFTKTELGDWDLLEKLLIRTVQHTSLAFHESLQRSDRGRYLLISAAGASSPTAGNAAYSAAKAAAEAWTLAMADYFRKAGGEQGPTSAAAILVVKALVHEAMRAERPNAKFAGFTDVRDLADAVADVWDKPAAEVNGTRLWLTEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4B5</accession>
    <name>Q9K4B5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5396</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629535.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973600.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9K4B5"/>
    <dbReference type="STRING" id="100226.SCO5396"/>
    <dbReference type="GeneID" id="1100836"/>
    <dbReference type="KEGG" id="sco:SCO5396"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5477"/>
    <dbReference type="eggNOG" id="COG2268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073070_0_0_11"/>
    <dbReference type="OMA" id="LHLETQT"/>
    <dbReference type="PhylomeDB" id="Q9K4B5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="310" mass="34605" checksum="06DAB0D942A55E72" modified="2000-10-01" version="1">MSDTSPYGFELVRRGYDRAQVDERISKLVSDRDSALARITALEKRIEELHLETQNAQAQVNDAEPSYAGLGARVEKILRLAEEEAKDLREEARRAAEQHRELAESSAQQVRNDAESYAAERKAKAEDEGVRIVEKAKGDASQLRSEAQKDAQSKRDEADALFEETRAKAAQAAADFETNLAKRREQSERDLASRQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQSEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLASLTGAAVAAAPSVEDESVSRGVPAQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4H6</accession>
    <name>Q9K4H6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7249</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031540.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7249"/>
    <dbReference type="GeneID" id="1102687"/>
    <dbReference type="KEGG" id="sco:SCO7249"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7349"/>
    <dbReference type="eggNOG" id="ENOG5033TII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601733_0_0_11"/>
    <dbReference type="OMA" id="QGVFLRY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="165" mass="17744" checksum="B2C707A8AE5D011F" modified="2000-10-01" version="1">MSFLRRRSATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQGVFLRYGLFGGRGPAMIIGNLPDGSPAREVPEGEIPFEVAQLLLALENDEEITVVGAEDVPVMQGDNLLIVRRLKLSESRISCVQFDRSDGVLVTIAAWDRPITDDLYALLKPLPAELFQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXM9</accession>
    <name>Q9KXM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628499.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974647.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4328"/>
    <dbReference type="GeneID" id="1099768"/>
    <dbReference type="KEGG" id="sco:SCO4328"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4397"/>
    <dbReference type="eggNOG" id="ENOG5033V4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132132_0_0_11"/>
    <dbReference type="OMA" id="SACDKPT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329121" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="154" mass="16478" checksum="493107479988C76E" modified="2000-10-01" version="1">MRRRRAVAAVGAVSAGLLLLSACDEPTPIATITVGSDSVSSEATCGGKGKNLSPDEINKCLKDKDAKSITVDQDETVRFGVDPDIADKHWTILMNGQQLVEDSDKTYRTVPGSVFFNAQYGAQGDSTNVAVAVRDGKDDSQNITGVWVFELKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY29</accession>
    <name>Q9KY29_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2361</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626608.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028306.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2361"/>
    <dbReference type="GeneID" id="1097795"/>
    <dbReference type="KEGG" id="sco:SCO2361"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2399"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083285_1_0_11"/>
    <dbReference type="OMA" id="PLSYMTE"/>
    <dbReference type="PhylomeDB" id="Q9KY29"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="270" mass="29614" checksum="700DBE85E5FDDEBE" modified="2000-10-01" version="1">MPVLVASDLDRTLIYSAAALGLTMPDLRAPRLLCVEVYESKPLSYLTETAAQLLTDLGDSALFVPTTTRTRKQYQRINLPGPAPKYAICANGGHLLVDGVSDPGWHARVTARLADECASLAEVRDHLTNTADPLWVRKHRVAEDLFAYLVVERDLLPQDWVKELAVWAENRGWTVSLQGRKIYAVPKPLTKSAAMHEVARRTGAELTLAAGDSLLDADLLLAADRGWRPGHGELADSGWTAPTISALPERGVLAGERILREFLRAVRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYF7</accession>
    <name>Q9KYF7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2715</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626949.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028535.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2715"/>
    <dbReference type="GeneID" id="1098149"/>
    <dbReference type="KEGG" id="sco:SCO2715"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2770"/>
    <dbReference type="eggNOG" id="COG3919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041670_0_0_11"/>
    <dbReference type="OMA" id="DWFFHGY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="130"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="432" mass="46677" checksum="0CBE8AD352587258" modified="2000-10-01" version="1">MSLFDTRVPAVVLRMDRNPFHHGTLGAVRSLGRAGVDVHVVADCADSPVRASRYLSGLHTPPPPGAPPAEIAAVLRRVAARLARPAVLIPMDDACAVAVGRARTELAPWYLLPDQPGELPARVADKAELAGVCASLDVPHPETLVPDGAAEAARAAWRLGLPVVAKWSRPWLVPPGGGLRSTVLVRSAREAGELYLRAEEAGSRLLLQAFLPPGADRDWFFHGYADHFGAVRAGGPGRKTRARPRGAGLTAVGRWTPNPQVQALAERVTAELGYRGVFDLDFRRCGTTGRYHLLDFNPRPGAQFRLFTDTAGLDVVRALHLDLTHRPLPQGAPRPGRVFVVENYAPLNALRPAREGHGGRELAWHARDDRAPGRALWALWGRHVSARLRDRVHRGGARPGAPAPSGARVVRQASAPPADHADRPDEDRARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYJ1</accession>
    <name>Q9KYJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP /GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626915.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2681"/>
    <dbReference type="GeneID" id="1098115"/>
    <dbReference type="KEGG" id="sco:SCO2681"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2737"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_125_8_11"/>
    <dbReference type="InParanoid" id="Q9KYJ1"/>
    <dbReference type="OMA" id="YGEQGKW"/>
    <dbReference type="PhylomeDB" id="Q9KYJ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="43"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="779" mass="86485" checksum="23302F1BD3EAB58F" modified="2000-10-01" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ43</accession>
    <name>Q9KZ43_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7089</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031423.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7089"/>
    <dbReference type="GeneID" id="1102527"/>
    <dbReference type="KEGG" id="sco:SCO7089"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7191"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9KZ43"/>
    <dbReference type="OMA" id="QAGVAHH"/>
    <dbReference type="PhylomeDB" id="Q9KZ43"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="397" mass="42849" checksum="717DDDB7670509BE" modified="2000-10-01" version="1">MSARWRNRITDRPHTVETLTMGLLLAFTLGGVILTRAVAVEEPVELWPGLALSVLACAALLRRRSRPLLVLLVTTGCVIAEGFLGYLLTPLLMGPMLVAQYTVSLRPDRRATWSSALAAAAGIACTGFVVTDAHEWIIGLVNPAAWVLMAALFGSYVRVRREYAMARAEHAAQERDEEARRRVIHERMRIARELHDVVAHHLALANAQAGTAAHLARTHPDQAIVMIEKLPDVTASALRELKATVGLLRQETDAKELAPAPGLEQLPRLVETCASAGLDVTITTEGRPHALTPGLNLTAYRIVQEALTNVTKHAATPSARVRLIYTPHYLTLTVTNDIGSRPTSAADIHSRGRGFGLLGMRERALSAGGTFHAGPRPGGGFEVACSLPLPRSEESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ89</accession>
    <name>Q9KZ89_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative succinate dehydrogenase membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4857</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629012.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029907.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4857"/>
    <dbReference type="GeneID" id="1100298"/>
    <dbReference type="KEGG" id="sco:SCO4857"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4935"/>
    <dbReference type="eggNOG" id="COG2142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145876_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ89"/>
    <dbReference type="OMA" id="WLFMRLS"/>
    <dbReference type="PhylomeDB" id="Q9KZ89"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17587" checksum="E8D7D60DBBC2AEC2" modified="2000-10-01" version="1">MSTTESPASGIGPIEGASLYSADNPAPLIEAPRARTKKSPKSTRGNFEMAAWLFMRLSGVVLVVLVLGHLLIQLVLDGGVSKIGFAFVAGRWASPFWQVWDLLMLWLAMLHGANGLRTVINDYAERPNTRLWLKGLLYTATVFTILLGTLVIFTFDPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZA0</accession>
    <name>Q9KZA0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4846</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629001.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974125.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4846"/>
    <dbReference type="GeneID" id="1100287"/>
    <dbReference type="KEGG" id="sco:SCO4846"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4922"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050028_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZA0"/>
    <dbReference type="OMA" id="MGNQFGA"/>
    <dbReference type="PhylomeDB" id="Q9KZA0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB89065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="33843" checksum="54F38CDF4881D339" modified="2000-10-01" version="1">MERDERGQGRIMDWLKKLPVAGPWIARLMTTHAWRSYERLDRVKWSRLAAAMTFTSFVALFPLLSLAAAVAAATLNKQQQDKLQDKLAEQIPGISDQLNIQGLVDNAGTVGVISALLLLFTGMGWIEATRGCLRAVWELPDEDENPVLHRAKDAGVLVGLGGALLITVGISTVASALVGWIIRTIGLAQGGVGGVLLYVAAFAVAVLADFLLLLYVLTLLPGVQPERRRLVVAALIGAVGFELLKLLLSGYIQGVAAKSMYGAFGVPVALLLWINFTAKLVLFCASWTATGSKAQELGEPGDADVTDGSGGGPGPAAATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZK0</accession>
    <name>Q9KZK0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3045</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627267.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975766.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3045"/>
    <dbReference type="GeneID" id="1098478"/>
    <dbReference type="KEGG" id="sco:SCO3045"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3105"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZK0"/>
    <dbReference type="OMA" id="MVDFNAV"/>
    <dbReference type="PhylomeDB" id="Q9KZK0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="108"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="385"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="53806" checksum="C157401372D109D3" modified="2000-10-01" version="1">MPPQRRRRPEPEAPAPGRRGRRPEKKKSRGKRVLLWTGGSMAFVVLVAGVGGYVYLKHLEGNVSTTDVGTAGSSSFKKDEAFNILIIGTDKRTGEGNEGYGDKGSAGHADTNILLHVAEDRSNATALSIPRDLIVDIPDCETTQEDGTKKVIPGTSGVRFNQSLGDFGRDAGCTMRTVAETTGIKPDHFMMADFNAVKTLTTAVDGVDVCVEHAVDDPKSHLKLPAGESKVEGEQALAFVRTRHAFGNEGDLDRIKVQQQFLGSLMRKMASGDTLTSPTKLVKLAEAATKALTVDSAIGKVGTLKDIALELKKVPTKNITFTTVPVIDNPAEKVKATVVVNEAKGPQVFDMIKNDISFTEVEQQKKKEKAAVAARLKGEKSEPGEVRVRVMNGGAPAGSAQQELAYLQTQAGVSKSENAGNAPADIAKTTLEYAPDQADQARALAEILGLTGAAMKPGESVTNSQGLPTMTLTLGKDFKGAGVKLDGSVKKPDLDTESTADQKLCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN8</accession>
    <name>Q9KZN8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1394</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625677.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027761.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1394"/>
    <dbReference type="CAZy" id="GH31">
        <property type="family name" value="Glycoside Hydrolase Family 31"/>
    </dbReference>
    <dbReference type="GeneID" id="1096820"/>
    <dbReference type="KEGG" id="sco:SCO1394"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1403"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_11"/>
    <dbReference type="InParanoid" id="Q9KZN8"/>
    <dbReference type="OMA" id="LPRGRWY"/>
    <dbReference type="PhylomeDB" id="Q9KZN8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="795" mass="85660" checksum="D958E9229668954C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZY7</accession>
    <name>Q9KZY7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">SCO4439</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029654.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4439"/>
    <dbReference type="GeneID" id="1099879"/>
    <dbReference type="KEGG" id="sco:SCO4439"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4509"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011372_0_0_11"/>
    <dbReference type="OMA" id="VAAMMSY"/>
    <dbReference type="BRENDA" id="3.4.16.4">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="13">
        <location>
            <begin position="505"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="14">
        <location>
            <begin position="737"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="9">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAB88446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="832" mass="84224" checksum="A02645EBDC63EF47" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L011</accession>
    <name>Q9L011_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2302</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626550.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028264.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2302"/>
    <dbReference type="GeneID" id="1097736"/>
    <dbReference type="KEGG" id="sco:SCO2302"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2339"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024319_1_1_11"/>
    <dbReference type="OMA" id="TEVQPMG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="422" mass="43245" checksum="4020E69070FB6417" modified="2000-10-01" version="1">MTACAIEPSADPGNSGAPRAGCSITAAGAYAARLARSGQDGDSWYPERWTLDGPEPYAVPLPGNQPEEAGTEVQPMGDGRVLVHRVAAGRHVFALLYPTGPGTGELPLGAVECPADTTGPRLLPPAPGGERAYALAAGPRSTVLWEVAGGAFGPERVAEIPGRCSGGVWLDRTGRMLAVDQETGGRTKAVVVDLERGGEVSPLLQIAADSDDRLLLADPDSGLVLIGSDAPSPGRQRLGWGVLGSTLPVRFPECLRMPDCVVTPFAIQPGQVLTPERCAVALRVDGAFGSWVGVWRPADRRVRHLPAPEGWLTGAGLWTPDGELRLPCSTPQSPCGVARLAAPDAGGGRTEGANDAGDEGDPGDPGGPGDAADTADTEDTEESAHDGSGDPAATGPSTHASAPGRPCPVPLQQAPLARLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L042</accession>
    <name>Q9L042_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2993</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627216.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2993"/>
    <dbReference type="GeneID" id="1098426"/>
    <dbReference type="KEGG" id="sco:SCO2993"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3052"/>
    <dbReference type="eggNOG" id="COG3265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103816_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L042"/>
    <dbReference type="OMA" id="TVGWEVS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB87343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="19545" checksum="5D918A32FC137C1F" modified="2000-10-01" version="1">MTHTAGMDQEAGAYDLLLIGGGSGVGKSTVGREVSALLRAAGTAHCLIEGDGMDQIHPAPEGDPHRTGITERNIAAVWANYAALGQRRLLYTNTVSILEAPMIGRAMGGDEVRVTCVLLTADEATVRQRLAVRETGSQLGIHIERSLRMARRLAEEAPVGTVRVPTDGRAVRDIAAQVVRLAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L052</accession>
    <name>Q9L052_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2983</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627206.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028696.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2983"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1098416"/>
    <dbReference type="KEGG" id="sco:SCO2983"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3042"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003394_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L052"/>
    <dbReference type="OMA" id="WWGGTRR"/>
    <dbReference type="PhylomeDB" id="Q9L052"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB87333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="745" mass="83318" checksum="686165C534A96648" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0A0</accession>
    <name>Q9L0A0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative secreted peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2446</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626689.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028358.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2446"/>
    <dbReference type="GeneID" id="1097880"/>
    <dbReference type="KEGG" id="sco:SCO2446"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2487"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007528_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0A0"/>
    <dbReference type="OMA" id="FEYRTVW"/>
    <dbReference type="PhylomeDB" id="Q9L0A0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07490">
        <property type="entry name" value="Peptidases_S8_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034190">
        <property type="entry name" value="Peptidase_S8_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017296">
        <property type="entry name" value="Peptidase_S8A_SAM-P45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037852">
        <property type="entry name" value="Subtilisin_rel_SAV5721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176801" evidence="7">
        <location>
            <begin position="30"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="218"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB86111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1220" mass="127312" checksum="B9BD0018A7F31674" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0H0</accession>
    <name>Q9L0H0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4787</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628945.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974185.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4787"/>
    <dbReference type="GeneID" id="1100228"/>
    <dbReference type="KEGG" id="sco:SCO4787"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4861"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L0H0"/>
    <dbReference type="OMA" id="YYDEQLA"/>
    <dbReference type="PhylomeDB" id="Q9L0H0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="38"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB82026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="29260" checksum="0A7B10A40204C56E" modified="2000-10-01" version="1">MHGTPGAAEPPPLPTDRLRFAMPPRHDSVEDERRHRKERLAGALRLFGRQGFEDGVSGHITVRDPQYTDCFWVNPFGVPFAHITVSDLVLVNSEGQVVEGGHHVNQAAFTVHSQVHAARPDVVAVAHCHSVHGRALSALGEPLEPITQESCAFYEDHALYDSYSGVAVDAEEGRRIAGVLGSGKALVLRNHGLLTVGDSVDAAAWWFLSLERSCQVQLLAKAAGRPVPIGHRQAVATREQLGGDLVAWINYQPLWQEVTRREPDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0H4</accession>
    <name>Q9L0H4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4783</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628941.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029862.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1100224"/>
    <dbReference type="KEGG" id="sco:SCO4783"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4857"/>
    <dbReference type="HOGENOM" id="CLU_2208489_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="107" mass="10322" checksum="F68C78C5C767E092" modified="2000-10-01" version="1">MLGEGFAGADVVGCVSSGAGVPSPVVLGETGEVGEAEELEDGLVESLGAGEVTLVDPPWDGALSEEADGDGDGPPLAEAAGAASRATGQITAVAAAAARARRSFMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0J9</accession>
    <name>Q9L0J9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC-transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4666</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029799.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4666"/>
    <dbReference type="GeneID" id="1100107"/>
    <dbReference type="KEGG" id="sco:SCO4666"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4738"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9L0J9"/>
    <dbReference type="OMA" id="THCEKSH"/>
    <dbReference type="PhylomeDB" id="Q9L0J9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB81857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26164" checksum="2EBFF9753BE0AB62" modified="2000-10-01" version="1">MTSDDAIRLSSVSRRYGAGEGTVTALDDVSLALRRGSFTAVMGPSGSGKSTLLQCAAGLDRPTSGSVVVGGTELTGLSQRRLTLLRRERVGFVFQAFNLLPSLTAAQNVALPLRLAGRRPPRGRVREALRQVGLADRARHRPAELSGGQQQRVALARALITRPQVLFADEPTGALDSRTGREVLTLLRAMADGEGRTVVMVTHDPVAASYADRVLFLVDGRVHDELTGSGPDGIATRMTRLEAAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0V6</accession>
    <name>Q9L0V6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3749</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029208.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3749"/>
    <dbReference type="GeneID" id="1099185"/>
    <dbReference type="KEGG" id="sco:SCO3749"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3809"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099459_0_0_11"/>
    <dbReference type="OMA" id="RLNRWQA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="23301" checksum="1BCB57FF902CD0AC" modified="2000-10-01" version="1">MHVPVRPATTEPHGRPAGTRLPGPAQRSSPQAGERLRPLTRRQIEDRFAELGNLYAQTSGGGPRAWNVARGAFLRRLAADVRRPGFGLLIAETTVLTGCAYGYPVPGGDPPGVRGLERYLTGSVLPVAASGRLFLVSGIVVPARVRREHHDRAWNLARRLQARLLAEHDAVLGVTLVDRADGATVRALRSWGWRYAEGDTLQSSVLGPYGVLVLGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-10" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Y6</accession>
    <name>FMT_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">SCO1473</name>
        <name type="ORF">SCL6.30c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625754.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027805.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0Y6"/>
    <dbReference type="SMR" id="Q9L0Y6"/>
    <dbReference type="STRING" id="100226.SCO1473"/>
    <dbReference type="GeneID" id="1096899"/>
    <dbReference type="KEGG" id="sco:SCO1473"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1482"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L0Y6"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="PhylomeDB" id="Q9L0Y6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071951">
        <property type="term" value="P:conversion of methionyl-tRNA to N-formyl-methionyl-tRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083056" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="310" mass="32639" checksum="A2BA4098D6F21C2E" modified="2000-10-01" version="1">MKLVFAGTPEVAVPALDALIASGRHEVAAVVTRPDAPAGRGRRLVASPVAERAEEAGIEVLKPAKPRDPDFLERLREIAPDCCPVVAYGALLPRVALDVPARGWVNLHFSLLPAWRGAAPVQHALMAGDEITGASTFLIEEGLDSGPVYGTVTETVRPTDTSGDLLTRLAFAGAGLLAATMDGIEDGSLEAVPQPAEGVTLAPKITVEDARVDWTAPALRVDRVVRGCTPAPGAWTTFRGERLKLVQAVPLPDRSDLAPGQLAAGKNNVYVGTGSHAVELLWVQAQGKKPMRAADWARGARITEGERVGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L127</accession>
    <name>MPRR2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Small neutral protease regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mprR</name>
        <name type="synonym">mprR2</name>
        <name type="ordered locus">SCO7433</name>
        <name type="ORF">SC6D11.29</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Transcriptional trans-activator of the gene (mprA) for the small neutral protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031660.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L127"/>
    <dbReference type="SMR" id="Q9L127"/>
    <dbReference type="STRING" id="100226.SCO7433"/>
    <dbReference type="GeneID" id="1102871"/>
    <dbReference type="KEGG" id="sco:SCO7433"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7543"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="OMA" id="HEVEGCP"/>
    <dbReference type="PhylomeDB" id="Q9L127"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000105684" description="Small neutral protease regulatory protein">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="328" mass="35885" checksum="2BA97730AE4FA16B" modified="2000-10-01" version="1">MELEVRHLRALCAIADAGSLHRAARRLGVAQPTLSTQLTRIEQALGGPLFTRERTGCRPTPLGRTVLGRARPLLTDMNTLVREARAAAAGGDSRLRVGSTASRALAGWLRRLRRPGLEPTLQMDVSANALLRRVTDGQLDVAFVHEVEGCALHIPEDLRLRVLVEREPQFVMLPADHPAAARPVVRLADLADDRWMVDPTVDGEWDGVHRMLRAVGLNPRVLHGDYHTAASLVATGEVVTVCQPSSQSRPDTAVRRLYGDPLGVRLLLAARTRAELDAVFPALEDAYWEAARQSTAYREWLEGGGIRTLPRCPVAATGGGRVEFVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L140</accession>
    <name>Q9L140_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7419</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631468.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031652.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7419"/>
    <dbReference type="DNASU" id="1102857"/>
    <dbReference type="GeneID" id="1102857"/>
    <dbReference type="KEGG" id="sco:SCO7419"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7529"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L140"/>
    <dbReference type="OMA" id="CNDFGGP"/>
    <dbReference type="PhylomeDB" id="Q9L140"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="20263" checksum="00E6B0F8678195D9" modified="2000-10-01" version="1">MVVGGFGVGKTTMVRSVSEIRPLNTEETMTQAGEAVDDISEVRGKSATTVAFDFGRISLDARNVLYLFGAPGQERFWFLWDRLFSGTLGAVVLVDTRRIDDSWYAIDRLEHHGTPFIVACNDFGGPEHSPEAVREALDLDPRVPLVSCDARSRQSSKQVLITLVEHLQAHYAGPTARPRQEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L173</accession>
    <name>Q9L173_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7404</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631454.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971739.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7404"/>
    <dbReference type="GeneID" id="1102842"/>
    <dbReference type="KEGG" id="sco:SCO7404"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7514"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L173"/>
    <dbReference type="OMA" id="MNRATAW"/>
    <dbReference type="PhylomeDB" id="Q9L173"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="28526" checksum="D59DF920B5CD5933" modified="2000-10-01" version="1">MTTDHTQPPQIDTGRAHPARVYDWLLGGKDNYPVDEAVGETLPPEARDAARQNRAFMNRAVAHLAARGIDQFLDIGTGIPTEPNLHQIVQRTVPAARVVYADNDPIVLRHAEALLVSSPEGATDYIQADVREPGEIVRHARGILDFDRPIALSLIALMHFVPDDQDAHGIVRGLVETLPAGSHLVLSHAALDLFPELAEQVIAQYAKGGIRLGFRTRAEVARFFDGLELVPPGLVTATEWYGEGLEPPAPEASGIYAGVARIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L204</accession>
    <name>Q9L204_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2629</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626865.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2629"/>
    <dbReference type="GeneID" id="1098063"/>
    <dbReference type="KEGG" id="sco:SCO2629"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2675"/>
    <dbReference type="HOGENOM" id="CLU_3158127_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="48" mass="5012" checksum="4CC4B4D1F265858E" modified="2000-10-01" version="1">MLGYMLTDTEHDGRSTVLLSLLVAALVVVVALVKQRITATRTAGAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L220</accession>
    <name>Q9L220_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ArsR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6812</name>
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    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630884.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031200.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6812"/>
    <dbReference type="GeneID" id="1102251"/>
    <dbReference type="KEGG" id="sco:SCO6812"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6921"/>
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    <dbReference type="HOGENOM" id="CLU_097806_3_2_11"/>
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    <dbReference type="OMA" id="MENNQSC"/>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Cerdeno-Tarraga A.M."/>
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                <person name="Quail M.A."/>
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                <person name="Howarth S."/>
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                <person name="Larke L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO0869"/>
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        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13200" checksum="98F1B73586436F54" modified="2000-05-01" version="1">MSVEAEVTVTVVDDVRIVRVAGDYDAVGAETLAHALALPAETGTSGTVVDLAKVTFADSSFLHTLLAAQYRHQTSGIPLVLAEVTPVLQRLLDLTDVTRAFTVAQTVPTATETVHARKSSTRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD97</accession>
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        <submittedName>
            <fullName evidence="8">Putative transmembrane efflux protein</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2854</name>
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    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
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                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="SSF103473"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="215"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="273"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="379"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="42"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB65584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="477" mass="47687" checksum="20797B126B148090" modified="2000-05-01" version="1">MTETGTDSPTTPTAPPTGTPATTAAAAPPPDRALPPPHPGRTLALTSAATAVALMAFTAPMVTLPETAADLHTSLSAQAWLLNGTPLGLAALLLVAGSLADDYGRRRLFVSGTLALGVTTVLGAFASTTWLFTLARVAQGAASAALLASSLGLLVHAFPTPAGRLRATGVWGAFVSGGIAVGPVLVGAIPDWRVAHGVLGAAALVVAGLGARALSESRSPREGRPDFAGALTFGPALVALVAALTLGRDGWLRAPVGLLLAAAVLLGALFVVLERRAATPMIDLSLLRRPLFLASSAGGLFTGLSVIGLFSFLPTVLQRALGLSPLDTALLSLLWAGLAFAVALQVRRIAHRVSPRHQLVVGFALHAVGVLTMLGAVGAGSWARLLPGLVVAGVGSGLLNAALPLLAVESVPAARAAMGSGAQQTFRYIGSCAGVALTIAIATSAGSPGAGTDVALWVSAGLAVAAGVLVATLRERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD98</accession>
    <name>Q9RD98_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028621.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2853"/>
    <dbReference type="GeneID" id="1098287"/>
    <dbReference type="KEGG" id="sco:SCO2853"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2913"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RD98"/>
    <dbReference type="OMA" id="QECSIAR"/>
    <dbReference type="PhylomeDB" id="Q9RD98"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="20273" checksum="8592CF771324C83C" modified="2000-05-01" version="1">MATVDGMALGKDYATQECSIARALEVVGERWTLLVIRDALYGVRRYNDFLVHLGIPRAVLANRLQALTAEGILEKRRYQESPTRDEYVLTERGIALWPALRALGIWGREQLGGEPMRTFWHADCGTELSPHGTCATCGTLVAVRDIDMRPGPGLAADPADPVSRALLGPRRLLQPIETEQRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDH4</accession>
    <name>Q9RDH4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative LacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2753</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626984.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976047.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2753"/>
    <dbReference type="GeneID" id="1098187"/>
    <dbReference type="KEGG" id="sco:SCO2753"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2809"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RDH4"/>
    <dbReference type="OMA" id="YVLNGPA"/>
    <dbReference type="PhylomeDB" id="Q9RDH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB66292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="348" mass="36269" checksum="37F3001F1A409D01" modified="2000-05-01" version="1">MTVTLADVAARAQVSPATVSRVLNGNYPVAASTRERVLKAVDELDYVLNGPASALAAATSDLVGILVNDIADPFFGIMAGAVQSEIGGPGGRAGGERLAVVCNTGGTPERELTYLTLLQRQRAAAVVLTGGAMEDETHQAAVAAKLRRLVEAGTRVVLCGRPPAPDTGAIALTFDNRGGGRELTEHLIGLGHRRLGYIAGPEERTTTRHRLEGHRTALAAHGIEEDPRWTVHGRYDREAGYEATLELLRRDPTLTAVVAANDTVALGACAALRDSGLRIPDDVSVAGFDDLPFSIDAVPALTTVRLPLAEAGARAGRVAMGREDAPVGGIATVRGELMVRGSSGGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDM8</accession>
    <name>Q9RDM8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626655.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028335.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2409"/>
    <dbReference type="GeneID" id="1097843"/>
    <dbReference type="KEGG" id="sco:SCO2409"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2450"/>
    <dbReference type="eggNOG" id="COG2951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034941_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDM8"/>
    <dbReference type="OMA" id="AVRPIYG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176877" evidence="2">
        <location>
            <begin position="37"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB62741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="421" mass="42256" checksum="29C699FC1C512EA9" modified="2000-05-01" version="1">MSVRRARRLYSGRARKGLRTTALAVAAMAALTASQAPGLTPDAEDSHAGPAADDLGLPTADGPFAALAPPGDGSYHTELPPLRTRKGGGPVPPALGPEIRAQSGIPATVLRAYRAAETAVGRTDPGCRLPWELLAAIGKVESGQARGGAVDRNGTTLGRITGPPLDGRGFALIRDTDGGAHDGDTVYDRAVGPMQFLPSTWARWGADGNGDGRADPNNVFDAALAAGHYLCVGDRDLGRAADLDRAVLSYNNSRTYLRLVRYWLEFYSRGVHPVPDGEGVLPRSPGAGGDTRATEPVDGAGGGGHGNAEGGGDGGIVIGPDPGTTPGSPGPSTPPAPSPSQDPSQPPTETPTETPTGSPGGTPTDTPAPSPDPTGASPSPTPTDDCTAEPGTASPDPTASPTDAPCPSPSDTAPAPGTSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDN6</accession>
    <name>Q9RDN6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626647.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028331.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2401"/>
    <dbReference type="GeneID" id="1097835"/>
    <dbReference type="KEGG" id="sco:SCO2401"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2442"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_2_11"/>
    <dbReference type="InParanoid" id="Q9RDN6"/>
    <dbReference type="OMA" id="VAPHNVG"/>
    <dbReference type="PhylomeDB" id="Q9RDN6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="42673" checksum="92F14CC00F1DEF1D" modified="2000-05-01" version="1">MRITGISTHVVGTPWRNLTYVQVHTDEGLTGVGETRMLGHTDALLGYLKEAEANHIVGSDPFAVEDLVRRMKYGDYGRAGEIVMSGIAVVEMACWDIKGKALGVPVWQLLGGKVTDKVKAYANGWYTTERTPEAYHKAAQGVMERGYRALKIDPFGTGHFELDQQQTNYAVSLIEAVRDAIGPDAELMLEMHGRFSPSTAVRLARELAPFRPAWLEEPVPPENLKALRKVAEKVDIPVATGERIHDRIEFRELFEDQSVDVIQPDVGHIGGIWETRKLAATAETHYTLVAPHNVGGPVLTAASLQVGFTSPNFKILEHFNDFADAEIKKVVKGAPRVDPEDGCFHLSDAPGLGVELDTDAAAEFPQQQARFDLWAEGWEKRAPKGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI61</accession>
    <name>Q9RI61_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37016">
        <property type="entry name" value="T37016"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624457.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026858.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0117"/>
    <dbReference type="GeneID" id="1095541"/>
    <dbReference type="KEGG" id="sco:SCO0117"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.94"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_11"/>
    <dbReference type="InParanoid" id="Q9RI61"/>
    <dbReference type="OMA" id="AWIFATC"/>
    <dbReference type="PhylomeDB" id="Q9RI61"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="23792" checksum="08F9BC4EC81A1C7F" modified="2000-05-01" version="1">MELKNAVAVVTGANRGFGRHLAAQLVERGAKVYGAARRPETVDVPGVIPLLLDVTDEASIREATRVASDTTLLINNAGISTGATLLGGDMTEVRRDMETNYFGPLATTRSFAPVIEANGGGAVLNVLSALSWFHPAGLGSYAASKAAAWALTGATRDELAPRGIAVSALHVGYMDTDMAADVPADQKVDAGEVAAQALYGIETGLPEVLADETSRHVKQSLAAAPQPNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI69</accession>
    <name>Q9RI69_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0108</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37008">
        <property type="entry name" value="T37008"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624451.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026852.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095533"/>
    <dbReference type="KEGG" id="sco:SCO0108"/>
    <dbReference type="HOGENOM" id="CLU_3141024_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="49" mass="5441" checksum="2AC97D4316ACEE6D" modified="2000-05-01" version="1">MLRKTIKVQWLGDEEFGMVGRPRAITHDPESCEKTVSLKALRDPCGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIA1</accession>
    <name>Q9RIA1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0074</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36974">
        <property type="entry name" value="T36974"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624427.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026830.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0074"/>
    <dbReference type="GeneID" id="1095505"/>
    <dbReference type="KEGG" id="sco:SCO0074"/>
    <dbReference type="HOGENOM" id="CLU_3391568_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="32" mass="3399" checksum="A3AAD1C42914D9E2" modified="2000-05-01" version="1">MGGTAAPLHPLRLVQDGFRGGDADVLAWFWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIZ9</accession>
    <name>Q9RIZ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0166</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36948">
        <property type="entry name" value="T36948"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624502.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978711.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0166"/>
    <dbReference type="GeneID" id="1095590"/>
    <dbReference type="KEGG" id="sco:SCO0166"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.139"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RIZ9"/>
    <dbReference type="OMA" id="NPRICRV"/>
    <dbReference type="PhylomeDB" id="Q9RIZ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB53133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="31701" checksum="3576CB92EE8BADA3" modified="2000-05-01" version="1">MAGTELRKISGKVYEKELRRLQIELVNLQEWVLTEKKRVAVVFEGRDAAGKGGTIKRLTEHLNPRVTRIVALPRPTERERTQWYFQRYVEQLPAGGEIVLFDRSWYNRAGVEHVMGFCTDDEYRRFLRHCPVFERMLVEDGLLLRKYWFSVSDVEQQERFRRRLQDPLKRWKLSTMDLESITRWEAYSRAKDEMMAATDTPESPWYVVESDDKRRARLNMIAHLLDSLPHHRVPPPSLRLPERPPPTGYTRSPRDRQTYVPDHAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJE4</accession>
    <name>Q9RJE4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0748</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625051.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978113.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0748"/>
    <dbReference type="GeneID" id="1096171"/>
    <dbReference type="KEGG" id="sco:SCO0748"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.738"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_2_11"/>
    <dbReference type="InParanoid" id="Q9RJE4"/>
    <dbReference type="OMA" id="CGIATNI"/>
    <dbReference type="PhylomeDB" id="Q9RJE4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="193" mass="20178" checksum="8AB9C83EFA8204F4" modified="2000-05-01" version="1">MTVTALDPRTALVVIDLQAGIVAAPTEPYSGAEVVARSAELAEAFRARDLPVVLVRVSFAADGADAVPGRTEAGAGGPRPEGWDVVVGELAGHPGDLTVTKRNWGAFHGTGLDVQLRRRGVTQIVLTGIATSIGVESTARAAHEHGYHVTLATDAMSDMSAEAHRGSVERIFPRLGETGTTRDILELLAKTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJJ1</accession>
    <name>Q9RJJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0397</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978468.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0397"/>
    <dbReference type="TCDB" id="2.A.66.11.1">
        <property type="family name" value="the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1095820"/>
    <dbReference type="KEGG" id="sco:SCO0397"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.373"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038929_0_0_11"/>
    <dbReference type="OMA" id="QLFASAC"/>
    <dbReference type="PhylomeDB" id="Q9RJJ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="43669" checksum="ABFB5AE003FC0664" modified="2000-05-01" version="1">MTVEGEKTTTPAEPARRGVVGRLSWGLADQAASSLSNFVVGIYVARSLGLTAFGVFSLAWVTYGVVLNVSRGLATDPLVVRFSGVPESSWRGAVARASGAALLVGAGIGTVSLVAGLAIGGQVGAAFAALGVVLPGLLLQDAWRYSFFAAGVGRKAFVNDVVWAVALVPAMVVAARAGSVPAFLLAWGGSAAVAGVYGWFQSGIRPRPAGAREWHRDHRDLGYRYLVENVGVSGAGQIRAYGLGAIVGVGAVGVIRGAELLLGPFLAVLMGLSLVTVAEAARVLRQAPRRLGKFCFLLGAGQTVAALLWGAALLLVPDRLGELVLGDVWSGASELIVPVTLSVAGAGLGTGAAAGLRALAAARRSLRCQLFASACYVAGGLGGAVAGGTVGSAWGAAAASVCGSVVWWLQLRAALRERDHHSIPEVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK5</accession>
    <name>Q9RJK5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0383</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624705.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027072.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0383"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1095806"/>
    <dbReference type="KEGG" id="sco:SCO0383"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.359"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_36_2_11"/>
    <dbReference type="InParanoid" id="Q9RJK5"/>
    <dbReference type="OMA" id="FVFDQHD"/>
    <dbReference type="PhylomeDB" id="Q9RJK5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB58324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="45321" checksum="9B03DEBE316C5639" modified="2000-05-01" version="1">MENLSVPFDRRVWQEATTLRDAGWDVHVICPRGSKRDTEPEAVVDRVHIHRYPLRAATGGPAGYLREYGAALWHTARLARRVGPVDVVHACNPPDLLFLPALWLKRRGARFVFDQHDLIPELYLSRFGRGKDLLYRAVCALERWTYRAADVVLATNESYKDVAIRRGGRRPDDVFVVRSAPATDRFQPVPPEPELKRGKPHLLCYLGVMGPQDGVDYALRALAKLRDEVGRTDWHAVFVGSGDAFDAMVELSRSLGLDEQVRFTGRIPDADLVRHLSTADVCLSPDPRNPLNDVSTMNKVLEYMAMGRPIVSFDLREARVSAGEAALYAPANDEAAFARLVARLLDDPDERARMGKIGQERVTGRLSWRNSQAALLAAYAAACRDHTPVSAGAPVRTGFKAGKRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJR9</accession>
    <name>Q9RJR9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0417</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624738.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027099.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0417"/>
    <dbReference type="GeneID" id="1095840"/>
    <dbReference type="KEGG" id="sco:SCO0417"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.393"/>
    <dbReference type="eggNOG" id="ENOG502Z8YY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072540_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJR9"/>
    <dbReference type="OMA" id="WLPWMKM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014990">
        <property type="entry name" value="DUF1838"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08894">
        <property type="entry name" value="DUF1838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="28332" checksum="A3BC24F175D95FA0" modified="2000-05-01" version="1">MTTPAQSLRSLARTRASLDGEEVTYWWSGSVFAWAPDEPYERLFGFEGVNVARLVHDAEDGPDSYRLLTREAAFYLDPVTGDILETWRDQPVVHVWNDPANQKWRPFPVPTTDLGDQVCFSLEIPLAYPSPLPTAQYPRHSAGDMYRALELFQFFARREDLAGPDPSVPATMSWTRMSPWVPWMARGGRPGGLTYHCRGRKLGSYTEVPERTRAHIAGHHPRFARAPERWSEPNETSWTYFRALNPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJY5</accession>
    <name>Q9RJY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1185</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625475.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027637.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1185"/>
    <dbReference type="GeneID" id="1096608"/>
    <dbReference type="KEGG" id="sco:SCO1185"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1184"/>
    <dbReference type="eggNOG" id="ENOG502ZAPJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032968_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJY5"/>
    <dbReference type="OMA" id="CLLAPAC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="667" mass="67673" checksum="4BEE0A8AE2AF1FA8" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJZ4</accession>
    <name>Q9RJZ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dihydroxy-acid dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1176</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625466.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027630.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1176"/>
    <dbReference type="GeneID" id="1096599"/>
    <dbReference type="KEGG" id="sco:SCO1176"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1175"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RJZ4"/>
    <dbReference type="OMA" id="FDFAIMK"/>
    <dbReference type="PhylomeDB" id="Q9RJZ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="596" mass="63786" checksum="F03425F39088E2BE" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK75</accession>
    <name>Q9RK75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0535</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624849.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027188.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0535"/>
    <dbReference type="CAZy" id="CBM3">
        <property type="family name" value="Carbohydrate-Binding Module Family 3"/>
    </dbReference>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="GeneID" id="1095958"/>
    <dbReference type="KEGG" id="sco:SCO0535"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.515"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573527_0_0_11"/>
    <dbReference type="OMA" id="YAGWHDL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001956">
        <property type="entry name" value="CBM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036966">
        <property type="entry name" value="CBM3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00942">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01067">
        <property type="entry name" value="CBM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51172">
        <property type="entry name" value="CBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176927" evidence="2">
        <location>
            <begin position="33"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CBM3" evidence="3">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="187"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB59592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="473" mass="50526" checksum="47AE1E4CDFCC264D" modified="2000-05-01" version="1">MRNRPTAGRARLALALSVLLGGGALTALPAQAAPAADGLTVQYRTSASGATADQTEPWFKVRNTGSSIVQLSQVKIRYYFKADSPNASYRFACSWAVRGCAAVTGTFGTLANPTAAADRYLEIGFTSAAGTLAPGADTGDLQLRFYQSNWQPLRQSDDYSFGGGQTSYATWDKVTAQLAGATVWGTAPEGNDPTDPTDPTDPPGGGQTLFDDFDYSSHTDPAIAAHGWSVRSNSGGPGVPGATWDPSKVTFVSAGGNSVMNLETSTAGTGASTTQTEVLTKSVKFKDGTYAARVKFADTPKSGPDGDHLVQTFFTINDLKAPMADDYAEYDFEYLPNGGWGEPSNILYTTSWETYNPDPWQAVNQHSEQRSSYAGWHDLVVTIDAGAITYYVDGQPFGTHDAQYLPERPMSINFNQWLIDLNGQTSTTPRSYDQQVDYVLHVKDQVLTPAEVAAKVAGYRAAGTGFVDEVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK99</accession>
    <name>Q9RK99_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0263</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624593.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026970.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0263"/>
    <dbReference type="GeneID" id="1095687"/>
    <dbReference type="KEGG" id="sco:SCO0263"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.236"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_25_0_11"/>
    <dbReference type="InParanoid" id="Q9RK99"/>
    <dbReference type="OMA" id="VDALCYV"/>
    <dbReference type="PhylomeDB" id="Q9RK99"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="371" mass="38774" checksum="207F8CD44AEAF3FD" modified="2000-05-01" version="1">MNTPGSALADLARSGRPIGVGVIGLGAHGSWAERSHLPALRAVGGFELRALSTSSKQSAERSGHKHGVRRAFGTAAELAACDEVDLVVVAVKVPHHRELVRTVLNAGKSVLCEWPLGNGLAEAEDMARLARAHAVPTVVGLQARSHPAFAYTRHLVADGYVGEVLSTTVVGSGGAWGATVGPADHHVLDAANGATLLTVPFGHALDGVASVLGEPEELRIQAASRRTSAVDTETGRPVPMTAADQVVASGRLPGGAVATFHYRGGMSRGTNFRWEINGTEGDLVLTAPVGHPQLSPLTLEGGRGTSTALAPLTVPEAYARVARLEPRADAPAYAVAHAYQRFLDDLREGTAHVPDFAHGVVRHRSIEQYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKG5</accession>
    <name>Q9RKG5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase remnant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3472</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627675.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3472"/>
    <dbReference type="GeneID" id="1098909"/>
    <dbReference type="KEGG" id="sco:SCO3472"/>
    <dbReference type="HOGENOM" id="CLU_2481867_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="87" mass="9744" checksum="5FD23D059EEB9F08" modified="2000-05-01" version="1">MGSKYTKRYLEEYKRDAIELVRSSGRTVTEAARELGISRSEPFQVRYGFGRDFSRTPETRGRCVGASAGHPHLPRRALGMPCTGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKI1</accession>
    <name>Q9RKI1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3451</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627655.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028992.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3451"/>
    <dbReference type="GeneID" id="1098888"/>
    <dbReference type="KEGG" id="sco:SCO3451"/>
    <dbReference type="eggNOG" id="ENOG5031QTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2411867_0_0_11"/>
    <dbReference type="OMA" id="VWAECRE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="103" mass="11437" checksum="AE203E1BE5865536" modified="2000-05-01" version="1">MKKQRVPGPGRVWAECREKIRHIRLRGEVEAYADGQLTGAHRMQVAAHIACCWACSGSLQLLRLIKASLRHSPQRTPPSLASARVRRFAQDLSAPTGRDRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKJ5</accession>
    <name>Q9RKJ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4091</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628272.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003949541.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKJ5"/>
    <dbReference type="STRING" id="100226.SCO4091"/>
    <dbReference type="GeneID" id="1099528"/>
    <dbReference type="GeneID" id="58435848"/>
    <dbReference type="GeneID" id="63981485"/>
    <dbReference type="GeneID" id="67397645"/>
    <dbReference type="KEGG" id="sco:SCO4091"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4150"/>
    <dbReference type="eggNOG" id="COG2452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196700_2_0_11"/>
    <dbReference type="OMA" id="LENSGMM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="68" mass="7546" checksum="CB0F7693722720C8" modified="2000-05-01" version="1">MTARTPDAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGGHRRYREAEVRALLAGIPQQRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKU8</accession>
    <name>Q9RKU8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630344.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030764.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6244"/>
    <dbReference type="GeneID" id="1101685"/>
    <dbReference type="KEGG" id="sco:SCO6244"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6358"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RKU8"/>
    <dbReference type="OMA" id="LFGAAHW"/>
    <dbReference type="PhylomeDB" id="Q9RKU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="207" mass="21388" checksum="A49A8D9AFE37A473" modified="2000-05-01" version="1">MTDNETPAEDQVGDRVAGLLLAAGGGRRLGGRPKALLEHRGHPLVEHAVEVLRTAGCARVHVVLGARAADVRARAALDGCTLVDNPDWEQGMGSSLRAGLGSLAATGARAALVCLVDQPGIGAAATARVRARFRDETSLASAAYAGVRGHPVLLGAAHWAGVAATASGDRGARAYLREHEAEIALVECGDVARPYDIDTEADLVHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKZ8</accession>
    <name>Q9RKZ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0320</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624647.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027015.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0320"/>
    <dbReference type="GeneID" id="1095744"/>
    <dbReference type="KEGG" id="sco:SCO0320"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.294"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_19_3_11"/>
    <dbReference type="OMA" id="QWFPLER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB55677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="157" mass="16024" checksum="DC0B38741DB38A99" modified="2000-05-01" version="1">MVAAASSDAKLALARDLGAEVVVDYTRADWVERVREATGGGAALVYDGAGGALGATSVDALADGGRFVTYGTADGFAAPDRESAARRGIRLLMPLMDGPPDQETARELLGLALESAAEGRLRPAIGATYPLARAADAHRALAARTTVGKSLLLMGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RMI9</accession>
    <accession>Q7APJ0</accession>
    <name>Q9RMI9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.197</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="1999" name="Plasmid" volume="42" first="174" last="185">
            <title>The linear plasmid SCP1 of Streptomyces coelicolor A3(2) possesses a centrally located replication origin and shows significant homology to the transposon Tn4811.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Bibb M."/>
                <person name="Gust B."/>
                <person name="Seitz B."/>
                <person name="Spychaj A."/>
            </authorList>
            <dbReference type="PubMed" id="10545260"/>
            <dbReference type="DOI" id="10.1006/plas.1999.1419"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2000-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Spychaj A."/>
                <person name="Redenbach M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="6">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="7">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF195093">
        <property type="protein sequence ID" value="AAF12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639793.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039495.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095275"/>
    <dbReference type="KEGG" id="sco:SCP1.197"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8136"/>
    <dbReference type="HOGENOM" id="CLU_1905509_0_0_11"/>
    <dbReference type="OMA" id="KPAYHRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046051">
        <property type="entry name" value="DUF6009"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19472">
        <property type="entry name" value="DUF6009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14941" checksum="06F05FAC97E914F6" modified="2000-05-01" version="1">MSSLISADEISHEAELVWLEDVDQLDYVRQSLDRLPTRKGKPPYHRDGRMVGYAILGPEAKASRASGTFRRRVFWVLPHDRDSEPDGLYAKSAPAEAVDPRTLQPRVKGYKTERSEGGPPSRAMQELGIQLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1N7</accession>
    <name>Q9S1N7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37169">
        <property type="entry name" value="T37169"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026963.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0254"/>
    <dbReference type="ESTHER" id="strco-SCJ9A.33C">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1095678"/>
    <dbReference type="KEGG" id="sco:SCO0254"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.226"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_3_1_11"/>
    <dbReference type="InParanoid" id="Q9S1N7"/>
    <dbReference type="OMA" id="IRCPVWA"/>
    <dbReference type="PhylomeDB" id="Q9S1N7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26125" checksum="410D8063DE055206" modified="2000-05-01" version="1">MTTITTRTVEYAADGLTMIGHLALPPGADRRPAVLLGPEGMGLSDVERGRADALAELGYAALAFDLHGGRYLGDPEEMLARCLPLLADPDRMRGIGHAALDVLRTQPRTDPGRIAAVGYGTGGAVGLELGRDGVDLRAIGTVNALTTGRPGEAERIRCPVWAGVGSQDPIMPPEQRNAFTAEMQAAGVDWRLTVYGGALHAFHHPPVDHPTVPGVGYHPRHAQRAWRDVVDLLAECLPLAEDRGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1R8</accession>
    <name>Q9S1R8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0223</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011026938.1">
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3333354_0_0_11"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="38" mass="4366" checksum="5C68719841BB2E65" modified="2000-05-01" version="1">MNPPSRRHHKAADRSPCVPERIDRGDTDTQERMAPPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1V5</accession>
    <name>Q9S1V5_STRCO</name>
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        <submittedName>
            <fullName evidence="2">Putative sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0037</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37101">
        <property type="entry name" value="T37101"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624395.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026797.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0037"/>
    <dbReference type="GeneID" id="1095470"/>
    <dbReference type="KEGG" id="sco:SCO0037"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.29"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_22_0_11"/>
    <dbReference type="InParanoid" id="Q9S1V5"/>
    <dbReference type="OMA" id="CIDASAE"/>
    <dbReference type="PhylomeDB" id="Q9S1V5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="65"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="27256" checksum="F1FCFF5DBDAA6C4F" modified="2000-05-01" version="1">MAEGRPRGHPRTGAFLATVTTRLAISTARSARVRREAYVGPWLPEPVDTSADPQLGAERAEAVEMAVLLLLERLNPVERAAYVLREAFDYSYRQVAAILETSEGNARQLVSLARKHLATERREQVSRGEHQRLLEVFLTAAQTGDLRTLEEALAADVVSYADGGGIRGASRIPVVGRSYVSKYLTAFAPRFWPGAQVRWVEANDRPAVLVHSDGKAVALLSIDASTQGIDRLMWVTNPGKLASYAASSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Z4</accession>
    <name>Q9S1Z4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0132</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T37062"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624471.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026872.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0132"/>
    <dbReference type="GeneID" id="1095556"/>
    <dbReference type="KEGG" id="sco:SCO0132"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.109"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="InParanoid" id="Q9S1Z4"/>
    <dbReference type="OMA" id="WTRRPAL"/>
    <dbReference type="PhylomeDB" id="Q9S1Z4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="848"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="919" mass="97473" checksum="2B76407D28016F75" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2G4</accession>
    <name>Q9S2G4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO2917</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36140">
        <property type="entry name" value="T36140"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627143.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028662.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2917"/>
    <dbReference type="GeneID" id="1098350"/>
    <dbReference type="KEGG" id="sco:SCO2917"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2975"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S2G4"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="PhylomeDB" id="Q9S2G4"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="163"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB50998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="47436" checksum="3A3FF94DC16CB597" modified="2000-05-01" version="1">MDVADLGLPVDVPSTALFTDQYELTMLRAALKAGTAGRRSVFEVFTRRLPDGRRYGVVAGTGRVLDAVENFRFDADVLRFLREQDIVDEETLDWLAQYRFSGDIWGYPEGEVYFPGSPIMRVEGTFGECVLLETVILSILNHDSAIAAAASRMSSAAGPRPLIEMGARRTHELAAVAAARSAYVGGFATTSDLAAGFRYNIPTVGTSAHAFTLLHDNERDAFRAQVDALGRDTTLLVDTYDVAEAVRTAVEVAGPELGAVRIDSGDLLLVAHRVRQQLDELGATETKIVVTSDLDEYAIASLAAAPVDAYGVGTQLVTGSGHPTASMVYKLVARAESGAEGAPLVPVAKKSSGGKTSVGGRKWAARRLDADGHAEAEVVGTGPVPDALADRQLLVELVKGGEVVAREPLDAARDRHAAARANLPLSATQLSRGEPVIPTEYAHGGSGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2N4</accession>
    <name>THIG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiazole synthase</fullName>
            <ecNumber evidence="1">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiG</name>
        <name type="ordered locus">SCO2109</name>
        <name type="ORF">SC6E10.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35490">
        <property type="entry name" value="T35490"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626366.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976707.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2N4"/>
    <dbReference type="SMR" id="Q9S2N4"/>
    <dbReference type="STRING" id="100226.SCO2109"/>
    <dbReference type="GeneID" id="1097543"/>
    <dbReference type="KEGG" id="sco:SCO2109"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2143"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2N4"/>
    <dbReference type="OMA" id="PHNFQLI"/>
    <dbReference type="PhylomeDB" id="Q9S2N4"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000162863" description="Thiazole synthase">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <sequence length="264" mass="27392" checksum="AF5D5AD9FC6BAB23" modified="2000-05-01" version="1">MADDPFVLGGTTYASRLIMGTGGAPSLDVLERALVASGTELTTVAMRRVNASVHGSVLSVLERLGIRVLPNTAGCFTAGEAVLTARLAREALGTDLVKLEVIADERTLLPDPVELLDAAETLVDDGFTVLPYTNDDPVLARKLEDAGCAAIMPLGSPIGSGLGIRNPHNFQLIVEHARVPVILDAGAGTASDVALAMELGCAGVMLASAVTRAQEPVLMAAAMRAGVEAGRLARRAGRIPRRHFAEASSPAEGLAVLDPERPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2T4</accession>
    <name>Q9S2T4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2055</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35084">
        <property type="entry name" value="T35084"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626315.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028118.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2055"/>
    <dbReference type="GeneID" id="1097489"/>
    <dbReference type="KEGG" id="sco:SCO2055"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2087"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023173_0_0_11"/>
    <dbReference type="OMA" id="WMAVLWA"/>
    <dbReference type="PhylomeDB" id="Q9S2T4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="525" mass="57516" checksum="DB53557BBE6C7784" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U4</accession>
    <name>Q9S2U4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2041</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35070">
        <property type="entry name" value="T35070"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028112.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2041"/>
    <dbReference type="GeneID" id="1097475"/>
    <dbReference type="KEGG" id="sco:SCO2041"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2072"/>
    <dbReference type="eggNOG" id="ENOG502ZNJH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172614_0_0_11"/>
    <dbReference type="OMA" id="GAFMVMA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="83" mass="8567" checksum="286619B1095EC83D" modified="2000-05-01" version="1">MAGSSHGHTPAAWTGVIIAFIGFCIAGMFMVAAQPWGFWAGMAVVLLGGVVGYIMKMMGLGQPKQNHPVHQVAGERAEAGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WW65</accession>
    <name>Q9WW65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotide sugar-1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6753</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35278">
        <property type="entry name" value="T35278"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630825.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031156.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6753"/>
    <dbReference type="GeneID" id="1102192"/>
    <dbReference type="KEGG" id="sco:SCO6753"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6862"/>
    <dbReference type="eggNOG" id="COG1213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_5_0_11"/>
    <dbReference type="InParanoid" id="Q9WW65"/>
    <dbReference type="OMA" id="AYSLWCA"/>
    <dbReference type="PhylomeDB" id="Q9WW65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB39686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="27320" checksum="01E9C3B43A3A7405" modified="1999-11-01" version="1">MIGLVLAAGAGRRLRPYTDTLPKALVPVGPEGAEDSITVLDLTLANFAEVGLTEVGIIVGYRKEAVYDRQAELEQKYGVKLTLIDNDKAEEWNNAYSLWCGRDALKDGVILANGDTVHPVSVEKTLLAARGDGKKIILALDTVKNLADEEMKVVVDPDKGVQRITKLMDPADATGEYIGVTLIEGEAAAELADALKTTFERDPQLYYEDGYQELVNRGFKVDVAPIGDVKWVEIDNHDDLAKGREIACQY</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7T0</accession>
    <name>Q9X7T0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7270</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35338">
        <property type="entry name" value="T35338"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631326.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971873.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7270"/>
    <dbReference type="GeneID" id="1102708"/>
    <dbReference type="KEGG" id="sco:SCO7270"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7372"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9X7T0"/>
    <dbReference type="OMA" id="EQCIAGV"/>
    <dbReference type="PhylomeDB" id="Q9X7T0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="31838" checksum="2682B6200C8A8A4D" modified="1999-11-01" version="1">MELRHLQHFVAVAEDQHFTRAAERLLVSQSGLSASIRALERELRAPLFVRTTRRVTLTEAGRALLEEARRILAQVRSAHEAVAAVQGVLRGTLSLGAEQCIAGVPVARLLAAFRRGHPDVEIRLRQAGSGELAEEVAAGRLDLAFAYRTQADTDQLRSVSLAGEPMTVLCHPDHRLAADGAVLTPHDLADEVFVDFHPDWGPRRVTDAVFAAAGVRRTVPLEVNDVHGLLDLIDENLGIAVVPRHFRHKRAALTSLPLKDADGTEYETIALLPSARATSPAARALMGLLETGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X805</accession>
    <name>Q9X805_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2146</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35528">
        <property type="entry name" value="T35528"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626402.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028165.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2146"/>
    <dbReference type="GeneID" id="1097580"/>
    <dbReference type="KEGG" id="sco:SCO2146"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2181"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X805"/>
    <dbReference type="OMA" id="LFCAHPL"/>
    <dbReference type="PhylomeDB" id="Q9X805"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="33"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="476" mass="50023" checksum="8DD7603B521645A1" modified="1999-11-01" version="1">MSVPTAVATPLPVLGRDVTVPLVTGGQVAYAALDYAASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTDLFENARGTVAGFLGCRDDDQVVFTRSTTDSLNLLAAALPAHCRVFVFETEHHASLLPWRAADVTYLDAPRTPAEAVETLERALAAREPYGPALVCVTGASNVTGELWPVRELAAAAHAHGARIVLDAAQLAPHHPVSVRDLDVDWVAFSGHKLYAPFGSGVLAGRADWLREAEPYLAGGGASRSVSRRADGGVDVQWHDSAARHEAGSPNVIGVYAIASACKALTEAGFDTLVAREEYLIRKVREGLAEVPEVRVLSLFGDDAPRVGVLSFVVEGWNSSHFAAALSAEYGIGVRDGLFCAHPLVRTLLGSDPQTQGECGAPEAAPGEKSLNAIRVSFGAGTPDEHVERFVSAVRELVSDGARWNYRTEDGRCVPDPASGDTASGDHASGDPASRGTAPVTGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8A5</accession>
    <name>Q9X8A5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36170">
        <property type="entry name" value="T36170"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627729.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029065.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1098965"/>
    <dbReference type="KEGG" id="sco:SCO3529"/>
    <dbReference type="eggNOG" id="ENOG5031MWU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111150_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="17641" checksum="3C9991A9BFACD233" modified="1999-11-01" version="1">MSPLPCRWFGEPLIPSDAFGVGSSSHSTSSARFGPCPPLFRFDGCWLPPFLPMLLVGVFSRVPGGPCGEEGPLAAVWGPDVGGAKHEPLRVVPEVGQGSEYGTECPQSRLTCGVSQTPRAGFHVARGTGGGGEEAAHILDHNQAGSEGCDCTGDMQPEPGAGLGVESGPAAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8A8</accession>
    <name>Q9X8A8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36173">
        <property type="entry name" value="T36173"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627732.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029068.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3532"/>
    <dbReference type="GeneID" id="1098968"/>
    <dbReference type="KEGG" id="sco:SCO3532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3589"/>
    <dbReference type="eggNOG" id="ENOG5031D6X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141062_0_0_11"/>
    <dbReference type="OMA" id="HKVYVDP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="158" mass="17242" checksum="08DB3EF5FC519117" modified="1999-11-01" version="1">MSRARFAFAAHPDAIADLRELPSEKRDLALLELQNLVHGSDDCLPLKGRLAGFHKVYVDPAVSYRLVIQFRQAPPTSTHKREIYLVAAGSRKDYAVYRAAHLRTEPQQGVGPDSATEARVQAARSRSTLTTERPTTGRAAAPSPAPPSATASRKATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8R1</accession>
    <name>Q9X8R1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipase/esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3644</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36534">
        <property type="entry name" value="T36534"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627838.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975294.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X8R1"/>
    <dbReference type="STRING" id="100226.SCO3644"/>
    <dbReference type="ESTHER" id="strco-estli">
        <property type="family name" value="Est9X"/>
    </dbReference>
    <dbReference type="GeneID" id="1099080"/>
    <dbReference type="KEGG" id="sco:SCO3644"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3704"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_10_1_11"/>
    <dbReference type="InParanoid" id="Q9X8R1"/>
    <dbReference type="OMA" id="GGWPTTF"/>
    <dbReference type="BRENDA" id="3.5.1.9">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034338">
        <property type="term" value="F:short-chain carboxylesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="31085" checksum="3F1509A0E7D46207" modified="1999-11-01" version="1">MPDAAAEPGTAAARDAAEEKSALSHPAVEPDSTAGYGDHPDQVIDFYLPRGGAGPGEAAPVVVVLHGGSWRAPYDRRHISPFAGFLARRGFAVASVEYRRGAEGPGAEGAGDDPVAGRWPDTFDDVAAALDALPELVRQHLPRADARRVVLTGHSAGGHLALWAAARHLLPADAPWLTDRPAPLRGVVALAPIADFEVADRLGVCGGAARQLLGDGELFAGRRPYADPALLLPTGIATTLVQGRADVDVPQAVAEAYADAAAKAGEVVGVTLLEDVGHYPLIDPAADACAVVAEEIAQLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8S4</accession>
    <name>Q9X8S4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3657</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36547">
        <property type="entry name" value="T36547"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975281.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3657"/>
    <dbReference type="GeneID" id="1099093"/>
    <dbReference type="KEGG" id="sco:SCO3657"/>
    <dbReference type="HOGENOM" id="CLU_1874206_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="12783" checksum="7B5F1DF9273B0A78" modified="1999-11-01" version="1">MRPGPGPGGGRAGRAPAGAATAAAAPTAGGRATGAVRPPTVTTRATPAVAARPAEAGRPAGEGAADAAEAAADTGQLSLSVRGNRIPSTGPAPGAGPRVPTTSARRAILPVGARTPGALRTGGVCARVEQLSCGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X938</accession>
    <name>Q9X938_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3585</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36694">
        <property type="entry name" value="T36694"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627781.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029101.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3585"/>
    <dbReference type="GeneID" id="1099021"/>
    <dbReference type="KEGG" id="sco:SCO3585"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3640"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056504_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="113" mass="12364" checksum="68EBBC1ADFD0EDD2" modified="1999-11-01" version="1">MSAEEIDARRYAITDTLDDPAGRDDPRERLFIATELVRRTGEPVQAVSGSWGGGGKWLARRLETTVPGLSTRLHHGLREVLDGRTEPLVTVVDEVLGQVGGRLWVGHKRAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA93</accession>
    <name>Q9XA93_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0832</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36445">
        <property type="entry name" value="T36445"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625132.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027378.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0832"/>
    <dbReference type="GeneID" id="1096255"/>
    <dbReference type="KEGG" id="sco:SCO0832"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.824"/>
    <dbReference type="eggNOG" id="ENOG5030UE2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847076_0_0_11"/>
    <dbReference type="OMA" id="EPFATYP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB48909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="34710" checksum="DF7814A04CC92229" modified="1999-11-01" version="1">MSVRDVEAAALDWVWTHRDRFALGDDALAADGQVNRTWKPLGELTQVCASVSRCTPPGDPLHTRVSELLDFAWQQTHRGELFPLMQSLEPFATYPLEVYAAFASAGLRHPGYEASAAVLTRTRGWRLTEQYPTRRLGVLEAERRSGIDPHGDVPQALDRTWLGGLPEPWTFERAAGYALTHVVFHLTDWGRAPGGVPARLAGYLLHWLPPWLDTCLDARMWDLSCELLAVAASLPRPPEGAVLEDAWQRVAAAQAGSGAIPEEGAAQDAAGADPGPDPYDFTDCYHSTLMAAFAAALTTAATAPPPKVRHAAQHAGQGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAH5</accession>
    <name>Q9XAH5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6689</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB46977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35549">
        <property type="entry name" value="T35549"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630763.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031107.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6689"/>
    <dbReference type="GeneID" id="1102128"/>
    <dbReference type="KEGG" id="sco:SCO6689"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6794"/>
    <dbReference type="eggNOG" id="ENOG502ZAPJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032968_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAH5"/>
    <dbReference type="OMA" id="RVHGVCR"/>
    <dbReference type="PhylomeDB" id="Q9XAH5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="588" mass="60264" checksum="A68E50793AA17504" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI6</accession>
    <name>Q9XAI6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3616</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35384">
        <property type="entry name" value="T35384"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627811.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3616"/>
    <dbReference type="GeneID" id="1099052"/>
    <dbReference type="KEGG" id="sco:SCO3616"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3674"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2720478_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="72" mass="7823" checksum="0BC5ED2DC8F68497" modified="1999-11-01" version="1">MRLTRDVAFEVTNTQFLARLVGRGLGVAMLPSAYVPRLGGVTTIQVTDAPARVEYAVWPLAAARPRRPRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAS3</accession>
    <name>Q9XAS3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4581</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34605">
        <property type="entry name" value="T34605"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628743.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974366.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4581"/>
    <dbReference type="GeneID" id="1100021"/>
    <dbReference type="KEGG" id="sco:SCO4581"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4653"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAS3"/>
    <dbReference type="OMA" id="WSVTLDR"/>
    <dbReference type="PhylomeDB" id="Q9XAS3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="28419" checksum="BBBDF331F506BE64" modified="1999-11-01" version="1">MDRTAYSLVATDLDGTLLRGDDTVSDRSLAALARVAGAGARHLVVTGRPAPRVRPLLDRLGCTGLAVCGQGAQVYDAGAHRMLWSVTLDRELAETALGKIEAEVGQVHAAVDQDGVDGLTLIEPDYLMPHPTLPAVRVERRAQLWSTPISKVLLRHPELTDDELAATARAVVGSLATVTMSGPGTVELQPCGITKATGLALAAEHLGLERRRTIAFGDMPNDIPMFQWAAHGVAMAGAHPELKAVADEVTTTNEDDGVAVVLERIFGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN1</accession>
    <name>Q9ZBN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative deacetylase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35485">
        <property type="entry name" value="T35485"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030714.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6178"/>
    <dbReference type="DNASU" id="1101619"/>
    <dbReference type="GeneID" id="1101619"/>
    <dbReference type="KEGG" id="sco:SCO6178"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6288"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBN1"/>
    <dbReference type="OMA" id="NHAMRDE"/>
    <dbReference type="PhylomeDB" id="Q9ZBN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004337976" evidence="1">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="65"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="28344" checksum="1CA456F27239FA41" modified="1999-05-01" version="1">MRVLATFAAAASLTLALSGCTKLETHSPSSVRNAADAQAADGKADASGTQARAGGLGTVDCAHTKCIALTFDAGPSENSARLLDILKEKQVPATFFLLGKRHIDTYPELVRRMADEGHEVASHTWTHKILTDAEPDEIREELERPNKEIERLTGERPILMRPPQGRTDDTVHDISRELGLAEVLWTVTAKDYKTNDSDLITERVLDQSSRDGIILLHDIYDGTVPAVPGIIDALKKRGYVFVTVPQLLAPGKAEPGKVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>O54123</accession>
    <name>O54123_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5927</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T34599"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011030536.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5927"/>
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    <dbReference type="KEGG" id="sco:SCO5927"/>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7507" checksum="240C5F6F9DDAA045" modified="1998-06-01" version="1">MWHQVGRSSGAAGVGGDDVDDGARRRVGDLISQAEREGDPEQAARSTVSSGSGGGGVRVIGSHRGRRCCRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O54142</accession>
    <name>O54142_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide synthase RedX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5878</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
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        <property type="entry name" value="T34830"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030509.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5878"/>
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    <dbReference type="KEGG" id="sco:SCO5878"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5977"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006644_0_0_11"/>
    <dbReference type="InParanoid" id="O54142"/>
    <dbReference type="PhylomeDB" id="O54142"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="521"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="982" mass="100944" checksum="0C7875874AEDF340" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O69958</accession>
    <name>O69958_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5782</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35102">
        <property type="entry name" value="T35102"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629906.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973241.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5782"/>
    <dbReference type="GeneID" id="1101224"/>
    <dbReference type="KEGG" id="sco:SCO5782"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5872"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_4_1_11"/>
    <dbReference type="InParanoid" id="O69958"/>
    <dbReference type="OMA" id="FIIGPHT"/>
    <dbReference type="PhylomeDB" id="O69958"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="18"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA18319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="411" mass="42073" checksum="2FF404912C7B85F1" modified="1998-08-01" version="1">MHSAVLLIEFGSIILGLGLLGRFAGRYRLSPIPLYLLAGLAFGEGGLLPLGASEEFVATGAEIGVILLLLMLGLEYTASDLVTNLKSHYPAGLVDCALNAVPGAVAALLMGWGPVAAVVLAGVTWISSSGVIAKVLGDLGRVGNRETPVILSVLVLEDLAMAVYLPIVTALVAGAGLMTGSITLAVALAAAGLVLFVAVRYGRLISRFVSSDDPEKLLLVVLGLTILVAGVAQQLQVSAAVGAFLVGIALSGEVAEGAHTLLSPLRDLFAAVFFVFFGLHTDPASIPPVLLPALALALLTAVTKIATGYWAARRAGISVKGRWRAGGALVARGEFSIVIAGLAVSAGIEPSLGPLATAYVLILVVLGPLTARFTEPLAMRLFPRRDNPDRPSGLAEGTPRAAATEEASVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O69964</accession>
    <name>O69964_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5788</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35108">
        <property type="entry name" value="T35108"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629912.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030454.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5788"/>
    <dbReference type="GeneID" id="1101230"/>
    <dbReference type="KEGG" id="sco:SCO5788"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5878"/>
    <dbReference type="eggNOG" id="COG3885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090899_0_0_11"/>
    <dbReference type="InParanoid" id="O69964"/>
    <dbReference type="OMA" id="SGRAPWQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174857" evidence="1">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="23683" checksum="34ED991955658587" modified="1998-08-01" version="1">MLVAAAVCPCPPLLVPEVAAGAAPELDAARAACTDALGVLAASRPDRLVVVGPADSAGPEVYPRDARGSFRGFGVDVEVYLGADSGGAGGAELPHGLAVGAWLLARTGWTDVPVDVIGVGEELSAERCAAVGRDVAARAGRTALLVLGDASACRTLKAPGYLDERAAPFDAEVGRALETADPAALAALDPGLARELKASGRAPWQVLAGAAGDSGLGGALLYEDAPYGVGYIVATWS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O69985</accession>
    <name>O69985_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5809</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35129">
        <property type="entry name" value="T35129"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629933.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973213.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5809"/>
    <dbReference type="GeneID" id="1101251"/>
    <dbReference type="KEGG" id="sco:SCO5809"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5901"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_5_0_11"/>
    <dbReference type="InParanoid" id="O69985"/>
    <dbReference type="OMA" id="WYADDPE"/>
    <dbReference type="PhylomeDB" id="O69985"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA18345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="31645" checksum="829619BDF5EAD76E" modified="1998-08-01" version="1">MTLHSSSDGRLDRALSSLRGLSVGDALGSQFFVPANYPLLGRRELPPGTWQWTDDTEMACSVVSVLAAHHRIDQDALAHSFAHHHDFDRGYGPAVNRLLRLVREGGDWRELAAALFNGQGSWGNGAAMRIAPLGAWYADDPEQATHQAEISAYPTHQHREAVVGAMAVAAAAALAADPAGPPAAHTLLDGVIALVPKSAVGAGLRRARDMLDYGDAATVAAVLGCGRRTTAHDTVPFALWSAARALRDYETAFWTTAQVGGDVDTTCAIVGGVIAAGKAGAPPAEWAERVEALPAWMTTSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O86511</accession>
    <name>CIMA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(R)-citramalate synthase</fullName>
            <ecNumber evidence="1">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cimA</name>
        <name type="ordered locus">SCO5529</name>
        <name type="ORF">SC1C2.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29059">
        <property type="entry name" value="T29059"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629663.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030295.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86511"/>
    <dbReference type="SMR" id="O86511"/>
    <dbReference type="STRING" id="100226.SCO5529"/>
    <dbReference type="GeneID" id="1100969"/>
    <dbReference type="KEGG" id="sco:SCO5529"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5616"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_7_0_11"/>
    <dbReference type="InParanoid" id="O86511"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="PhylomeDB" id="O86511"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000140470" description="(R)-citramalate synthase">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q74C76"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="534" mass="57527" checksum="3118EDDD6F732A50" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O86622</accession>
    <name>O86622_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6353</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29443">
        <property type="entry name" value="T29443"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630445.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030850.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6353"/>
    <dbReference type="GeneID" id="1101794"/>
    <dbReference type="KEGG" id="sco:SCO6353"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6465"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="InParanoid" id="O86622"/>
    <dbReference type="OMA" id="QSMRTIC"/>
    <dbReference type="PhylomeDB" id="O86622"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="255"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA20084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="459" mass="49137" checksum="7189FF2EFA11B367" modified="1998-11-01" version="1">MSGTRHRTRPALTAFLHRLAPRTLRGRLSLVALTTAALLMLILTVAFNAVAQHRLQHQADDELRTRAAAVATTIDTTGTTVRVLETSNDALLDTNVWIYADGRLLEEPPNAGPLTRVADALAGHGGRRCVTAGVDGPLRLCSQPVSGDNSEATVVTALGLSPYRSSADTLLLGSLALDAVMLACTYALTRLAVGRALRPVRTMTDQATQWSAVASEERFGHTRHPSELTRLGTSLDAILDRIRTLLRHERQLTGELSHELRTPLSRIIAELDWWQTRPRTADQTHATHKVIAEAAQSMRTICDTLLDDARGGAPTAPGTAEILPTLRRLTEVLDAPSHLTVTADGPPLEAGVPPALLERIISPLLTNASRYARSKITVHAYRAPDGVRIEVIDDGPGVPPPFAGQLFEPGRRADPGDGHSGAGLGLPLARRLARSAGGEMTYDPDHTPGARFVVSLPAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-04-07" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O86683</accession>
    <accession>Q53943</accession>
    <name>PGLZ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Alkaline phosphatase-like protein PglZ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Bacteriophage (PhiC31) resistance gene PglZ</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ORF2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pglZ</name>
        <name evidence="9" type="ordered locus">SCO6636</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="4681" last="4689">
            <title>Two genes involved in the phase-variable phi C31 resistance mechanism of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bedford D.J."/>
                <person name="Laity C."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="7642495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION IN ANTIVIRAL DEFENSE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1993" name="Mol. Microbiol." volume="7" first="329" last="336">
            <title>Genetic analysis of the phi C31-specific phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Laity C."/>
                <person name="Chater K.F."/>
                <person name="Lewis C.G."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="8446035"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1993.tb01124.x"/>
        </citation>
        <scope>GENETIC ANALYSIS</scope>
        <scope>PHASE REVERSION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="44" first="489" last="500">
            <title>Genetics of the phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Sumby P."/>
                <person name="Smith M.C."/>
            </authorList>
            <dbReference type="PubMed" id="11972785"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2002.02896.x"/>
        </citation>
        <scope>FUNCTION IN ANTIVIRAL DEFENSE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="46" first="917" last="932">
            <title>Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Hesketh A.R."/>
                <person name="Chandra G."/>
                <person name="Shaw A.D."/>
                <person name="Rowland J.J."/>
                <person name="Kell D.B."/>
                <person name="Bibb M.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="12421300"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2002.03219.x"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>POSSIBLE POST-TRANSLATIONAL MODIFICATION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="EMBO J." volume="34" first="169" last="183">
            <title>BREX is a novel phage resistance system widespread in microbial genomes.</title>
            <authorList>
                <person name="Goldfarb T."/>
                <person name="Sberro H."/>
                <person name="Weinstock E."/>
                <person name="Cohen O."/>
                <person name="Doron S."/>
                <person name="Charpak-Amikam Y."/>
                <person name="Afik S."/>
                <person name="Ofir G."/>
                <person name="Sorek R."/>
            </authorList>
            <dbReference type="PubMed" id="25452498"/>
            <dbReference type="DOI" id="10.15252/embj.201489455"/>
        </citation>
        <scope>CLASSIFICATION AND NOMENCLATURE</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2015" name="Virology" volume="477" first="100" last="109">
            <title>The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.</title>
            <authorList>
                <person name="Hoskisson P.A."/>
                <person name="Sumby P."/>
                <person name="Smith M.C.M."/>
            </authorList>
            <dbReference type="PubMed" id="25592393"/>
            <dbReference type="DOI" id="10.1016/j.virol.2014.12.036"/>
        </citation>
        <scope>FUNCTION IN A TOXIN-ANTITOXIN SYSTEM</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF ASP-535; ASP-694 AND 835-LYS--GLY-974</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4 5 8">BREX systems (bacteriophage exclusion) provide immunity against bacteriophage. Part of a type 2 BREX system (Probable). Previously called the phage growth limitation (Pgl) system, it confers protection against bacteriophage phiC31. The bacteria allows one cycle of phage infection, but subsequent cycles are impaired, protecting the original bacterial colony (PubMed:7642495). The system undergoes high rates (10(-3) to 10(-4)) of phase reversion, i.e. loss and regain of phiC31 resistance (PubMed:8446035). When the pglW-pglX-pglY-pglZ genes are transformed into a susceptible S.lividans (strain 1326) they confer resistance to infection by phage phiC31 and phiBT1; all 4 genes are necessary (PubMed:11972785).</text>
    </comment>
    <comment type="function">
        <text evidence="3">Probably an antitoxin component of a type II toxin-antitoxin (TA) system. Inhibits the toxic activity of its cognate toxin PglX.</text>
    </comment>
    <comment type="induction">
        <text evidence="4">Constitutively expressed, not induced by bacteriophage phiC31, probably part of a pglY-pglZ operon.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Deletion of the C-terminus (residues 835-974) still allows this protein confer phage resistance and act as an antitoxin to PglX.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Identified by mass spectrometry as a slightly larger than expected protein, suggesting it may be modifed with a low molecular weight adduct.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Strain is no longer resistant to plaque formation by bacteriophage phiC31 (a Pgl- phenotype).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the alkaline phosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="L37531">
        <property type="protein sequence ID" value="AAB00366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T30204">
        <property type="entry name" value="T30204"/>
    </dbReference>
    <dbReference type="PIR" id="T35045">
        <property type="entry name" value="T35045"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031062.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86683"/>
    <dbReference type="STRING" id="100226.SCO6636"/>
    <dbReference type="GeneID" id="1102075"/>
    <dbReference type="KEGG" id="sco:SCO6636"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6741"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330036_0_0_11"/>
    <dbReference type="OMA" id="WDADSRY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="chain" id="PRO_0000452168" description="Alkaline phosphatase-like protein PglZ">
        <location>
            <begin position="1"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Not necessary for Pgl+ phenotype or antitoxin activity" evidence="3">
        <location>
            <begin position="835"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Does not complement Pgl- phenotype of C-terminally shortened protein." evidence="3">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Does not complement Pgl- phenotype of C-terminally shortened protein." evidence="3">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="694"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Shortened protein, still complements a pglZ deletion and has antitoxin activity." evidence="3">
        <location>
            <begin position="835"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB00366." evidence="7" ref="1">
        <original>LVDAERGEDAAA</original>
        <variation>HARRRARRGRRR</variation>
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11972785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12421300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="25592393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="7642495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="8446035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="7642495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="25452498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="EMBL" id="CAA20547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="974" mass="104124" checksum="9D4F539EBDDBB247" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O86700</accession>
    <name>O86700_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6518</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35210">
        <property type="entry name" value="T35210"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630599.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030981.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6518"/>
    <dbReference type="GeneID" id="1101957"/>
    <dbReference type="KEGG" id="sco:SCO6518"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6621"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_13_11"/>
    <dbReference type="InParanoid" id="O86700"/>
    <dbReference type="OMA" id="TPYSYLM"/>
    <dbReference type="PhylomeDB" id="O86700"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17356" checksum="04CB76E1B12A8145" modified="1998-11-01" version="1">MTTLEDLARLRRARDLMDREYAEPLDVPALARVALMSAGHFSRSFRAAYGETPYSYLMTRRIERAMALLRRGDMSVTEVCFAVGCTSLGSFSSRFTELVGESPSAYRERDHADGAALPACVAKVYTRPVRNGEPGRSGTPAGKSESVRNGEAAPAPPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O86718</accession>
    <name>O86718_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6536</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35228">
        <property type="entry name" value="T35228"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630617.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972443.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6536"/>
    <dbReference type="GeneID" id="1101975"/>
    <dbReference type="KEGG" id="sco:SCO6536"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6639"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_0_0_11"/>
    <dbReference type="InParanoid" id="O86718"/>
    <dbReference type="OMA" id="ARVYDWW"/>
    <dbReference type="PhylomeDB" id="O86718"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="29271" checksum="16E50EFC92BB6E35" modified="1998-11-01" version="1">MTGPEPASAPLDTSRPHPARVYDWWLGGKDNYPVDEELARRILAADSTAVRGARANRRFMHRAVRTLAEAGIRQFLDIGTGIPTEPNLHQVAQAVAPESRVVYADNDPIVLRHAEALLHGSAEGATEYVHADVRDPDRILRLAGESLDFDRPVALSLVALTHYLGDAADGDDVHGLLKRYKDVLAPGSHLVLSQVTPDLNPAAVGKAAELFARGGTPFHPRSLTEFARFFDGLELLGPGIIPVTGWRPDPEDVAAQTEGIVPVYAGVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O86821</accession>
    <name>O86821_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5761</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA19862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35694">
        <property type="entry name" value="T35694"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629886.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030438.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5761"/>
    <dbReference type="GeneID" id="1101203"/>
    <dbReference type="KEGG" id="sco:SCO5761"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5850"/>
    <dbReference type="eggNOG" id="COG1201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_3_1_11"/>
    <dbReference type="InParanoid" id="O86821"/>
    <dbReference type="OMA" id="LPFWHGD"/>
    <dbReference type="PhylomeDB" id="O86821"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="35"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="271"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1690" mass="179123" checksum="52C1440F0347F275" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O88039</accession>
    <accession>Q53818</accession>
    <name>RAMA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter ATP-binding protein RamA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ramA</name>
        <name type="ordered locus">SCO6683</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="J. Bacteriol." volume="176" first="3800" last="3811">
            <title>Cloning and analysis of a gene cluster from Streptomyces coelicolor that causes accelerated aerial mycelium formation in Streptomyces lividans.</title>
            <authorList>
                <person name="Ma H."/>
                <person name="Kendall K."/>
            </authorList>
            <dbReference type="PubMed" id="8206859"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>A3(2) / M130</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2002" name="Mol. Microbiol." volume="45" first="45" last="57">
            <title>The ramC gene is required for morphogenesis in Streptomyces coelicolor and expressed in a cell type-specific manner under the direct control of RamR.</title>
            <authorList>
                <person name="O'Connor T.J."/>
                <person name="Kanellis P."/>
                <person name="Nodwell J.R."/>
            </authorList>
            <dbReference type="PubMed" id="12100547"/>
        </citation>
        <scope>OPERON</scope>
        <source>
            <strain>A3(2) / J1501</strain>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="11448" last="11453">
            <title>The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Kodani S."/>
                <person name="Hudson M.E."/>
                <person name="Durrant M.C."/>
                <person name="Buttner M.J."/>
                <person name="Nodwell J.R."/>
                <person name="Willey J.M."/>
            </authorList>
            <dbReference type="PubMed" id="15277670"/>
            <dbReference type="DOI" id="10.1073/pnas.0404220101"/>
        </citation>
        <scope>FUNCTION</scope>
        <source>
            <strain>A3(2) / J1501</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="64" first="602" last="613">
            <title>SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Capstick D.S."/>
                <person name="Willey J.M."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="17462011"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2007.05674.x"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Probably involved in exporting SapB from the cell (Probable). Expression of the ram locus (ramA, ramB and ramR) induces rapid aerial mycelium formation in S.lividans (PubMed:8206859).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">Probably part of the ramC-ramS-ramA-ramB operon.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Deletion of the ramC-ramS-ramA-ramB operon on rich medium leads to an initially bald (no aerial hyphae) phenotype; after 4 days develops a substantial aerial mycelium. No expression of SapB, normal expression of chaplins. Wild-type mycelium on minimal medium. A complete chaplin-negative plus ram-negative strain (deletion of ramR or the ramC-ramS-ramA-ramB operon) leads to the complete loss of robust aerial hyphae.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U03771">
        <property type="protein sequence ID" value="AAA21388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35182">
        <property type="entry name" value="T35182"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630758.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031101.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O88039"/>
    <dbReference type="SMR" id="O88039"/>
    <dbReference type="STRING" id="100226.SCO6683"/>
    <dbReference type="GeneID" id="1102122"/>
    <dbReference type="KEGG" id="sco:SCO6683"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6788"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="InParanoid" id="O88039"/>
    <dbReference type="OMA" id="GMWRTQA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000445441" description="ABC transporter ATP-binding protein RamA">
        <location>
            <begin position="1"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1 3">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="354"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA21388." evidence="10" ref="1">
        <original>D</original>
        <variation>G</variation>
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12100547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="8206859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="15277670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="8206859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="15277670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="636" mass="65481" checksum="04CA52FE1135E079" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q53956</accession>
    <name>SECF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Protein translocase subunit SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secF</name>
        <name type="ordered locus">SCO1515</name>
        <name type="ORF">SCL2.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1995-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Loriaux A."/>
                <person name="Frare P."/>
                <person name="Brans A."/>
                <person name="Dusart J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="X85969">
        <property type="protein sequence ID" value="CAA59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S52766">
        <property type="entry name" value="S52766"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625794.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977312.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q53956"/>
    <dbReference type="SMR" id="Q53956"/>
    <dbReference type="STRING" id="100226.SCO1515"/>
    <dbReference type="GeneID" id="1096941"/>
    <dbReference type="KEGG" id="sco:SCO1515"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1524"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_2_0_11"/>
    <dbReference type="InParanoid" id="Q53956"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="PhylomeDB" id="Q53956"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000095987" description="Protein translocase subunit SecF">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="373" mass="39711" checksum="28C55B23C62F82ED" modified="1997-11-01" version="1">MSKLGTLGARLHHGEVGYDFVKNRKIWYGISILITITAIVGLAVRGLHMGIEFQGGAVFTTPKNMSASVAQTETWAEEASGHDAIVQKLGDGSLRIQIAGTDTQQSDQIKEDLSKNLDVSAEKINADLVGPSWGDQIANKAWQGLGIFMVLVVIYLAIAFEWRMALAAFVALIHDITITVGIYALVGFEVTPGTVIGLLTILGYSLYDTVVVFDSLKEQTRDITKQTRWTYAEIANRSINSTLVRSINTTVVALLPVAGLLFIGGGVLGAGMLNDISLSLFVGLAAGAYSSIFIATPLVADLKEAEPQMKALKKRVLAKRAQGAAKGESAESAADEGAYDADEPDDAAPAVVGPRNQPASRGRGRGRPSGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKC6</accession>
    <name>Q7AKC6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7697</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631736.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031837.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7697"/>
    <dbReference type="GeneID" id="1103135"/>
    <dbReference type="KEGG" id="sco:SCO7697"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7817"/>
    <dbReference type="eggNOG" id="COG4247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044211_0_0_11"/>
    <dbReference type="InParanoid" id="Q7AKC6"/>
    <dbReference type="OMA" id="GLTIYYA"/>
    <dbReference type="PhylomeDB" id="Q7AKC6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:3-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="BP_Phytase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176017" evidence="1">
        <location>
            <begin position="32"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="435" mass="45940" checksum="D752480C4F8262C3" modified="2012-05-16" version="1">MHAFTRRLSGVVAATATLVFTAAAAVPPADASALAAPPEVLPRAETAALFDDDAGGNANADDPEIWRNSADPDASLVVATAKEGGLRVYDLDARQVQSVPAPEAPGADDAPGRFNNVDLVHGMSLGTGATDLAVVSDRGSDKLRVYRVDGDRPHAPLTDVTDPSAPWIFSGSQEEVNEESTAYGLATYTDSVTGRSYALVSQNATTRIALLELTATREGTVNYRKVRTLDLPATFTMPDGTKWSPCGEPGEGPQVEGMAVDPETGTLFAGQEDVGIWRLRADLRGRPVLQDKVREYGVPATYDEASDECVAGADPGFGGARVSADVEGLTLLEQEDGDGYLLTSSQGDDTFVAYDRERSDGYEYEGRFRVGAASEALDGSEECDGADVLAEPLGSRYPNGLLVVQDGHMAPEDGDREATGFKFVDLADVLEALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKI0</accession>
    <name>Q7AKI0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5073</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629224.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030039.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5073"/>
    <dbReference type="GeneID" id="1100514"/>
    <dbReference type="KEGG" id="sco:SCO5073"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5152"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="InParanoid" id="Q7AKI0"/>
    <dbReference type="OMA" id="CTANWIA"/>
    <dbReference type="PhylomeDB" id="Q7AKI0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="34100" checksum="DADD63E09F2D6843" modified="2012-05-16" version="1">MMRAVQFDRYGDPDVLYVAERPVPEPGPGQVRIAVDAVSVGHAQTQMRREAFPAPMWRPVFPVVLGGDVVGRITAVGPGVTALRPGDRVGAFTLYGAYAEQVVVDAVTVVPVPEELDAAEAAVLPGTGLIALGILRTGRLRKGETVLIHAAAGGVGHIAVQLARAAGAGLIIGTAGAAAKREFARATGADAVVDHRSAHWADEVRELTGGRGPDLILDGIGAEVLEQGVGLLAPGGRLVFYGSSGGELAIPKVSVMDLIGIKYVTGFALSAWRGGRPQEYEAGVAELTRLLAEGQVTSAVHARLPLERAAEAHAVVEARAQLGRVVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJW6</accession>
    <name>Q8CJW6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAD55318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36210">
        <property type="entry name" value="T36210"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733605.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028985.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3444"/>
    <dbReference type="CAZy" id="GH15">
        <property type="family name" value="Glycoside Hydrolase Family 15"/>
    </dbReference>
    <dbReference type="DNASU" id="1098881"/>
    <dbReference type="GeneID" id="1098881"/>
    <dbReference type="KEGG" id="sco:SCO3444"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3506"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_11"/>
    <dbReference type="InParanoid" id="Q8CJW6"/>
    <dbReference type="OMA" id="WVAACPD"/>
    <dbReference type="PhylomeDB" id="Q8CJW6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015927">
        <property type="term" value="F:trehalase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="228"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="617" mass="67571" checksum="E8494FEC24CB46A5" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK09</accession>
    <name>Q8CK09_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2023</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34866">
        <property type="entry name" value="T34866"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733555.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028102.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2023"/>
    <dbReference type="MEROPS" id="S54.A08"/>
    <dbReference type="GeneID" id="1097457"/>
    <dbReference type="KEGG" id="sco:SCO2023"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2053"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_974931_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK09"/>
    <dbReference type="OMA" id="PVCPRHP"/>
    <dbReference type="PhylomeDB" id="Q8CK09"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="104"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="30191" checksum="D04A4CD6F286EF4F" modified="2003-03-01" version="1" fragment="single">RYICPDCMRTAPVGHQCPECVREGARSVRRARTIAGGRISTTPVVTYVLFALNVLAYLAELVRPELVDRFAMVGSRLVAPDGTPLTGDGVFLSSGPLRVEGVAGGEWERMLTGAFLHQSPFEGTFGLLHITMNMVVLWQLGRVVELMLGRTRFAVLYLLSALGGSVLELVLADPWQASVGASGAVFGVGAAYYVLHRRLGAEMGRVNRFMAGLLLWLVVSAWFTSWQGHLGGLLVGGALALAYGYAPRDGRRAAVQAGAGAALVVLLAVTAAVKVSELTGGSVPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK24</accession>
    <name>ARGJ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Ornithine acetyltransferase</fullName>
                <shortName evidence="1">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglutamate synthase</fullName>
                <shortName evidence="1">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">argJ</name>
        <name type="ordered locus">SCO1579</name>
        <name type="ORF">SCI35.01c</name>
        <name type="ORF">SCL24.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Microbiology" volume="140" first="311" last="320">
            <title>Cloning and expression in Escherichia coli of a Streptomyces coelicolor A3(2) argCJB gene cluster.</title>
            <authorList>
                <person name="Hindle Z."/>
                <person name="Callis R."/>
                <person name="Dowden S."/>
                <person name="Rudd B.A.M."/>
                <person name="Baumberg S."/>
            </authorList>
            <dbReference type="PubMed" id="8180696"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="1"/>
    <dbReference type="EC" id="2.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAD55284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733539.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027859.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8CK24"/>
    <dbReference type="SMR" id="Q8CK24"/>
    <dbReference type="STRING" id="100226.SCO1579"/>
    <dbReference type="GeneID" id="1097010"/>
    <dbReference type="KEGG" id="sco:SCO1579"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1591"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_2_0_11"/>
    <dbReference type="InParanoid" id="Q8CK24"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="PhylomeDB" id="Q8CK24"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000002247" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000002248" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="1">
        <location>
            <begin position="179"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="383" mass="39512" checksum="4A7345A0A7754B3E" modified="2003-03-01" version="1">MSVTAAKGFTAAGITAGIKESGSPDLALVVNTGPRRSAAGVFTSNRVKAAPVLWSEQVLKSGEVTAVVLNSGGANACTGPKGFQDTHATAEKAADVLGTGAGEVAVCSTGLIGVLLPMDKLLPGVEAAAGQLSEHGGEKAAIAIKTTDTVHKTSVVTRDGWTVGGMAKGAGMLAPGLATMLVVITTDADLETEALDRALRAATRVTFDRVDSDGCMSTNDTVLLLSSGSSGVTPEYDAFAEAVRTVCDDLGQQLIRDAEGASKDIKVEVVNAATEDEAVQVGRTIARNNLLKCAIHGEDPNWGRVLSAIGTTDAAFEPDRLNVAINGVWVCKNGGVGEDRELVDMRYREVHIVADLAAGDATATIWTNDLTADYVHENSAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JB3</accession>
    <name>Q93JB3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7483</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031693.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102921"/>
    <dbReference type="KEGG" id="sco:SCO7483"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7595"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_4_2_11"/>
    <dbReference type="InParanoid" id="Q93JB3"/>
    <dbReference type="OMA" id="QVAWDAD"/>
    <dbReference type="PhylomeDB" id="Q93JB3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="13644" checksum="F639EB42E07F4FB8" modified="2001-12-01" version="1">MAITLVNPGGLPEIDVYRQVSIASGSKLVFVAGQVAWDADGVTVGEGDLAAQTEQCYLNVATALAAAGASFADVAKLNVHVADWTPDKMPLLLAGIERAAAKLGVTPAAPATLLGVAALDVPEHLVEVEATAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ1</accession>
    <name>Q93JJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626233.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028073.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1970"/>
    <dbReference type="GeneID" id="1097404"/>
    <dbReference type="KEGG" id="sco:SCO1970"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1996"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_4_0_11"/>
    <dbReference type="InParanoid" id="Q93JJ1"/>
    <dbReference type="OMA" id="NVDHICL"/>
    <dbReference type="PhylomeDB" id="Q93JJ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="16288" checksum="B4AC271C3BC51502" modified="2001-12-01" version="1">MSLGAMTDHTTRLDHIVLWVRDPVAAAGFYEKNLGLEPLRITEYAAGTVSFPSVRLNDETILDLAPHAMADRMRMVPGADASAGHPVNHICVSLSPHDFDALRTRLEEQSIPVSDLSYDSYGARGMARRSFYFGDPDGNIIEARHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RU8</accession>
    <name>Q93RU8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1878</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626145.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028026.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1878"/>
    <dbReference type="DNASU" id="1097312"/>
    <dbReference type="GeneID" id="1097312"/>
    <dbReference type="KEGG" id="sco:SCO1878"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1903"/>
    <dbReference type="eggNOG" id="COG2503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053338_3_0_11"/>
    <dbReference type="InParanoid" id="Q93RU8"/>
    <dbReference type="OMA" id="NSTHEPY"/>
    <dbReference type="PhylomeDB" id="Q93RU8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014403">
        <property type="entry name" value="APS1/VSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002674">
        <property type="entry name" value="VSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176596" evidence="3">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC38813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="28652" checksum="407BF5CA943799DD" modified="2001-12-01" version="1">MHKPLRIATVTATCAVAGAVLYTTGAASAGQSTANSTHEPYNIGVLAKDIDAYYGTTLDADGVYQASPDSPYAADLARVDAAAKKQIDRAARTAHHKHTRPAVVFDIDDTLLLSLDYEKKNNYGYDGATWAAYVDRADRPAVPGSPELARYADKKGVEVFYNSGLGEAQRAAAVENLKKAGADVNLDASHMFLKDKANPPSYLAHCATPGSWTCTTVQYKAGTRRHIERDLGYDVVANFGDQYSDLQGGYADRTYKLPNPTYFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QF8</accession>
    <name>Q99QF8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.14c</name>
        <name evidence="2" type="ordered locus">SCP1.340</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639590.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639948.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039316.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095093"/>
    <dbReference type="GeneID" id="1095422"/>
    <dbReference type="KEGG" id="sco:SCP1.14c"/>
    <dbReference type="KEGG" id="sco:SCP1.340"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7960"/>
    <dbReference type="HOGENOM" id="CLU_723435_0_0_11"/>
    <dbReference type="OMA" id="PHEFAIS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="382" mass="40642" checksum="50A673C7B252683A" modified="2001-06-01" version="1">MADQQLIDHAARHDLAITAKQLAGWRRAGLLPGNIPGGGLGQGRGSASTPPPESFDLVVALGRMSGRGKRPTDLALLLFAEGLPVPEATVRAAFRAAVDTATLPDEGDGEDDGLDLDERLDRLSHQLPDSGQTVTLVPARARRIDERIARILGKLPAELVELDHNAEPPRLTPQDATLTAVTATLGGSVPLQDIGALLRAMSPGLPANPFASLVETTQEDVPEAAARIIADDGSLTFIPDGDARDLLRALADTASLEDLAAGWHTAAQVREWALDLCQRVERELDAGQLGEAVEEWLHGRLLPSGVSVTETLRDRRWAPSKGAFSALMLLFQCQMFVLLDGLEPGCQWHVLQIPRVLPPPVRDLILSKAVGPETAAAGEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACP9</accession>
    <name>Q9ACP9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.269</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639879.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039571.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095352"/>
    <dbReference type="KEGG" id="sco:SCP1.269"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8214"/>
    <dbReference type="HOGENOM" id="CLU_2083488_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325715" evidence="1">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="123" mass="13264" checksum="8EB2EB3A446163A3" modified="2001-06-01" version="1">MTTARRTRRRIATVTAALTAAAGLLLVTASPASAEVKSTCGTYICVATAYQGRDYVQDITVTTRDGLPGTLRAFVGDYRGSKANASRWRFVVNQEIRAYPRLAVCGGLDRGGRVIENHCVMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACR0</accession>
    <name>Q9ACR0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.258c</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639868.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039560.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095341"/>
    <dbReference type="KEGG" id="sco:SCP1.258c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8201"/>
    <dbReference type="HOGENOM" id="CLU_110262_0_0_11"/>
    <dbReference type="OMA" id="RMAVYDR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="17320" checksum="16CE0ED63C0DB633" modified="2001-06-01" version="1">MLDQVAERAQKEGSIGKAGIGALLLFKRLRADTPWARALMATADADVRRATAAATAAVRDTALSLSDAARAGRAALAGLPGFTRGDALASTVLTAAAPHRMAVYDRRAHAGLRSLGIPLSNASGRYSRYIAALDHLLTRAPSPACAWTPRDLDIALYCLPPDTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACV3</accession>
    <name>Q9ACV3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.200c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639798.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039498.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095278"/>
    <dbReference type="KEGG" id="sco:SCP1.200c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8138"/>
    <dbReference type="HOGENOM" id="CLU_124976_0_0_11"/>
    <dbReference type="OMA" id="NAPANDF"/>
    <dbReference type="PhylomeDB" id="Q9ACV3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323097" evidence="1">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="17173" checksum="9AE99F43832A1479" modified="2001-06-01" version="1">MANTSRTRQALMAIAVSVLAAGVTTLGVAHADNGDAVAAAAEMPQAVEDFSYPGAAKIQAETGAILKRGNGHMLMTSCDGSEDIQVMSRTGQKDFCFNVMAKPAYLTLEVPQAYGIWTSADPVKTTIKDTDGTATVINAPANDFTGYGEAGSTGEPTTLIELRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACZ7</accession>
    <name>Q9ACZ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.154</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639727.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039453.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095232"/>
    <dbReference type="KEGG" id="sco:SCP1.154"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8100"/>
    <dbReference type="HOGENOM" id="CLU_021411_0_0_11"/>
    <dbReference type="OMA" id="AIGWAHA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="726" mass="79877" checksum="F58913E09908A95E" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD28</accession>
    <name>Q9AD28_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.122</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639695.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039421.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095200"/>
    <dbReference type="KEGG" id="sco:SCP1.122"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8071"/>
    <dbReference type="HOGENOM" id="CLU_1128529_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26834" checksum="C7F40BEE2526526F" modified="2001-06-01" version="1">MHSIQLISFGYLHLPTSPDGTPIPPAADRVEDVRDRLRDPAAARDILDLDGLHPRVQDVVAATPGARELLANLCEYATLPTRPRRIAIGCAGGRHRASALTELLAQALRERGYQVDVEHLHVRLPRVLDAARSQETVRPPVVVLCGSTKFWDALAEANLYETAAGRIVLAPGCDMKVAHPLWDEPGRAARLKDMLDALHRQKIALADQVLVVNPGGYIGESTRNEVAYARSLGKPIRFTHPVPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD46</accession>
    <name>Q9AD46_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.104</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639677.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039403.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095182"/>
    <dbReference type="KEGG" id="sco:SCP1.104"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8052"/>
    <dbReference type="HOGENOM" id="CLU_1703190_0_0_11"/>
    <dbReference type="OMA" id="QEWALDR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="154" mass="16951" checksum="6DC6C45EF80EA05E" modified="2001-06-01" version="1">MADELEDLVDIDVYDDGKPVEFGWLQGPNAAAILAAVRGQGPVPKTGLATRRQLRALGLRPGGQNAMPGLSWRNGRRKAYFYRIELALPKRTPTLAQERALDRAMAARQTCPTCRRRYHYCLPLRTLGSCLECYDGTPADPATYTLPPGHTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADK6</accession>
    <name>Q9ADK6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4954</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629106.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974022.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4954"/>
    <dbReference type="GeneID" id="1100395"/>
    <dbReference type="KEGG" id="sco:SCO4954"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5034"/>
    <dbReference type="eggNOG" id="ENOG502Z86B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082565_1_1_11"/>
    <dbReference type="InParanoid" id="Q9ADK6"/>
    <dbReference type="OMA" id="RDRMTWI"/>
    <dbReference type="PhylomeDB" id="Q9ADK6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="22707" checksum="090BC954E6644F81" modified="2001-06-01" version="1">MQQPQREVRAVHTASTVTVYQAYSPEIGLPAIREGRFPAAWKRDRMTWIKPSFLWMMYRCGWAAKAGQETVLAVEIGREGFEWALRHACLSSYQPGVHPDRATWQREVKRSPTRVQWDPERDLRLQPLPYRSLQLGLAGEAARRYADEWTVAIRDVTPLAHEIHGLVRDGDLDAARRLLPREQPYPAAEELLSNLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWE4</accession>
    <name>Q9EWE4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4863</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629017.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974108.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4863"/>
    <dbReference type="GeneID" id="1100304"/>
    <dbReference type="KEGG" id="sco:SCO4863"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4941"/>
    <dbReference type="eggNOG" id="ENOG5033AH7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127705_1_0_11"/>
    <dbReference type="OMA" id="YSAQSLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="15288" checksum="D56E35E2986FE36F" modified="2001-03-01" version="1">MTSGLTSGWTSGTTSPQQPRPSAAARPVRWAADAVATMREGARLRLDYSAQSLWRVDRMIDGIRGEEAPYAAVETALRGLGAYAGEVIVRQSGGEWWTTGGDHWVRTPDGRLWDPIDEARRCFAGDGSLRLLCRDATAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWI7</accession>
    <name>Q9EWI7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BcrAD_BadFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7597</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631639.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031768.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7597"/>
    <dbReference type="GeneID" id="1103035"/>
    <dbReference type="KEGG" id="sco:SCO7597"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7713"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_4_0_11"/>
    <dbReference type="InParanoid" id="Q9EWI7"/>
    <dbReference type="OMA" id="PANIMRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="7"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="32070" checksum="2578984ECCA07AB6" modified="2001-03-01" version="1">MTSVVAVDLGKTGCRAMLWNSADSSRAVNSVAGAPGLAAPDGVTAARAAVRAAVEPLLREAGGARPESVLVGAAGAASAPAAARSLVGALLEDLPVREAAVTSDAVTAHAGALGGRAGVVLAIGTGAVAVGIGADGTYARVDGWGPLLGDDGSGARIGTAGLRAALRAHDGRGPDTVLLDAAAGLFGDLERLPATVGRDGNPARTAATFAPEVARAADAGDAVAAAIVRDAAADLAETALAAARRITAGGEPLPAAVTGGLTGLGPALMAPLTAALTGSGLPVRLTSALGDPLDGARLLALDRATPHTSLVVRVRRTTANPSPTPATPPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWN6</accession>
    <name>Q9EWN6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7691</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631730.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031835.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7691"/>
    <dbReference type="GeneID" id="1103129"/>
    <dbReference type="KEGG" id="sco:SCO7691"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7812"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_2_1_11"/>
    <dbReference type="InParanoid" id="Q9EWN6"/>
    <dbReference type="OMA" id="RHEEGPR"/>
    <dbReference type="PhylomeDB" id="Q9EWN6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019996">
        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03494">
        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="203"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="471" mass="50254" checksum="86A42B74310F85C2" modified="2001-03-01" version="1">MSTGSRNIWEAWARSVPPLVCASTREPCHDPAATATRLARAGLAGQYVVYESEGGVWHFAAGSDVSVTADATGITARAAGRTWSSRTQRRPLTAFADALAALPPVSGLPDESGEERRFYGWAAFELAHLLHADPATAGDRPLLHALIPSVEVTLTGDSTVIRAVDEAWARKVADLLAEPAAEQTPHDEPARDRTEDVIAVGTAAYGRAVSRTVRDIRAGLLEKAVVSRQVPLPAEPRPDFPATYLAGRRANTPARSYVLDLGGYRAAGFSPETVLEVEDDGRVSTQPLAGTRALGADPAENERRRAELLSDPKEIHEHAVSVRLAWEEMAAVCRPGSVVVEEYMAVRPRGSVQHLASRVTGRLRPDAGPWDAFASLFPAITATGVSKRAALQALARHEEGPRGLYGGAVFRGSTSGALDAALVLRTLIGAGDEAWLRAGAGVTAQSSPERETEETCEKLRSVAPYLRFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWQ2</accession>
    <name>Q9EWQ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631714.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031821.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7675"/>
    <dbReference type="GeneID" id="1103113"/>
    <dbReference type="KEGG" id="sco:SCO7675"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7794"/>
    <dbReference type="eggNOG" id="ENOG50332AV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146762_0_0_11"/>
    <dbReference type="OMA" id="LWRHRIG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="17342" checksum="7544A79AF8909666" modified="2001-03-01" version="1">MTPAGDPRPRERRPAMSSQPTAPPPRRGGAGRVVRGAVRVLAAAGLAVDAYLHAHLADRYDPIASSVGQGTLFRLEAALAALAALLVLLWRRLPGDLFAASVAVGGLALLLVYRYVDVGELGPIPDMYEPVWYGEKEVTAVAQAVAALATLFLLLVRPRGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX35</accession>
    <name>Q9EX35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1004</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625300.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027511.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1096427"/>
    <dbReference type="KEGG" id="sco:SCO1004"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1001"/>
    <dbReference type="eggNOG" id="ENOG5030CBV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075074_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="28170" checksum="D3D1CE137470D3E4" modified="2001-03-01" version="1">MRAVLAANAEYRRVSTDVPSPFYGTCPGPSDLRPDKNAFIAQTSYRERPASRPSPGSNSWRTPTPWAAASGKTGQWALGAGPKTSSSDSGSSAAPDHTLEPALALRPARTRPVSLLLATLLAAPTLTGCTLMDLAQDCEGTDARVEELAALHILDSRPDEATAARGFEEVDAGCWSDSGDATVYAERTYAFPGTRADVAAHYRTAARQDGWIPAPDAAPDDLSFVKKTMNLRIVFLTAELLAEEGHGSRPDLSTGAGYSINVDSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX45</accession>
    <name>Q9EX45_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0993</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625289.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027502.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0993"/>
    <dbReference type="GeneID" id="1096416"/>
    <dbReference type="KEGG" id="sco:SCO0993"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.991"/>
    <dbReference type="eggNOG" id="COG2232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_6_0_11"/>
    <dbReference type="InParanoid" id="Q9EX45"/>
    <dbReference type="OMA" id="TGHMFPA"/>
    <dbReference type="PhylomeDB" id="Q9EX45"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="113"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="44010" checksum="E80BE759331B2EEE" modified="2001-03-01" version="1">MTVVCLESLTFGLGHLVRAADTLGERLTLLTRDRAYYAYELARLPVDALDVVVTDTFDVEGLTELLHRTPQLRGLISSTDTWTLAGAELTDRLGLPGLDPAVLRLTRDKAVVRNRLHDAGLTRGRAVEAPGAELRDVLLKEAGLPAVLKDTAGTGSQNVWLVRDEPELEAALDEAAGRQLKGRLFAEPYFSGPVYSAETLTWAGRTRLLGVSSRLMSPEPNFREEITAFPVAFPEARRAVLERWLGEVLAVIGYTDRFAHVEFVLTAGGPEVVEINPRIGGALVGEGLCRALGVNVYEAMIETALGRRPRLMDVDLPGGPAVAFVLGYPAAPGVFTGVAGLDRLADMPGSPAWYPVRSVGDPVEHLADSRGYAGIVYAEAETAELATHQAVAAANAVRVLTEPFPGTGDGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX48</accession>
    <name>Q9EX48_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0990</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625286.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027499.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0990"/>
    <dbReference type="GeneID" id="1096413"/>
    <dbReference type="KEGG" id="sco:SCO0990"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.988"/>
    <dbReference type="eggNOG" id="COG4097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849720_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EX48"/>
    <dbReference type="OMA" id="QAFGWSG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC14358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="36260" checksum="7FCAF72C802CE6D4" modified="2001-03-01" version="1">MLPETTPEDDGTTTQPPARDRRPPDRVVLRADLRAALPDASAAVVVTAAVFMFLYARMESGDSATVAVMPFMDDPGTYWMYLLSQAFGWSGLLWAWGTVMLGLLLSGPRPARLPVSRQALERLHRTTSLTTMALMSAHALMFAAELVRYEAQLAWAERLWAGFADTFVPGWYDSGTGRIAIPLGQGALYLAIPLGLLFYVRHRIGANTWRRLHRFVIVVYVLSVWHTLLYGTNVWYGEWPRTVLWLLQLPVAALLLARLLRPARRAERLGAPTRREGGALPGWVARAAGRVAAVAVVVGLLLVVVSGHDGGRERPAEPSSTSPHVHEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2S1</accession>
    <name>Q9F2S1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4468</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4468"/>
    <dbReference type="GeneID" id="1099908"/>
    <dbReference type="KEGG" id="sco:SCO4468"/>
    <dbReference type="eggNOG" id="ENOG502ZZP7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2792053_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="68" mass="7180" checksum="E8D93DAA9E352B76" modified="2001-03-01" version="1">MEICIAVADWARGPMTWVLDVPGGEGTDARRRKRPKHVRHTAPRASPTGSTGGPTGWGRGAGMVVGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2X7</accession>
    <name>Q9F2X7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4584</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628746.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974363.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4584"/>
    <dbReference type="GeneID" id="1100024"/>
    <dbReference type="KEGG" id="sco:SCO4584"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4656"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057675_0_0_11"/>
    <dbReference type="OMA" id="DGPDRQK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="420" mass="42385" checksum="DB62C4A25E704D03" modified="2001-03-01" version="1">MAPIDSDDNTTAGAGEELRAGRRKAARYVVPVAVMGVAAATIGLVPALADSGDPDLPKVTAEQLIEKIAKSDVQQLSGTVRISTDLGLPDLGGLESGLMSGMSGGPGSGGDDEGSAADPSAKLTELVSGSHTLRVAADGPDRQKLSLLENAAEYSLIHNGKDVWGYDSRSNEVYHSTAADGAERPEKDVPGQDVPATPKDFADQALKAVDDTTSVTVGGTAQVAGRDAYRLVVEPKQDGSTVGAITVAVDAETGTPLKFTLTPASGGAAVVDVGFTKVSFAKPDASTFDFTPPEGAKVTEADEADEAGRRAGAPEHGRGAEGGLAKGMNGLEVIGEGWNSIAAFDTGAQGGLPTDSAGDLGGLGDLGGFLGSFGDQVRGDFGSGTVFKTRLVNALITDDGKVYAGAVTKDALVKAADAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F367</accession>
    <name>Q9F367_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4421</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628589.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974562.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4421"/>
    <dbReference type="GeneID" id="1099861"/>
    <dbReference type="KEGG" id="sco:SCO4421"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4490"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086310_0_0_11"/>
    <dbReference type="OMA" id="PATFYQY"/>
    <dbReference type="PhylomeDB" id="Q9F367"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19352">
        <property type="entry name" value="TetR_C_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="22705" checksum="EF709F4FFF2A5C99" modified="2001-03-01" version="1">MRTVDGRVAGRRGQATRQKLLDCLSEMLSSSPYRDVKVIDVARKAGTSPATFYQYFPDVEGAVLEIAERMAAESSSLAGLTAGRSWVGKAGWQTAQELVDGFLEFWRKNDAILRVVDLGAAEGDKRFAKIRMKILNSVNSPLTDSVADLQAKGKVDKDVNPAAIAGSLVVMLAAAASHQKGFSSWGVKQAELKPHLALLTYLGITGKKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBK1</accession>
    <name>Q9FBK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal-transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5157</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030090.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5157"/>
    <dbReference type="GeneID" id="1100598"/>
    <dbReference type="KEGG" id="sco:SCO5157"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5240"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_2_11"/>
    <dbReference type="InParanoid" id="Q9FBK1"/>
    <dbReference type="OMA" id="IQKYFRD"/>
    <dbReference type="PhylomeDB" id="Q9FBK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC01358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="371" mass="41634" checksum="998A4F70D9C851FA" modified="2001-03-01" version="1">MSMIRDLRAAVRPSRVSLRKDGGAYDTTRDPATASAVVDCAVYHDGTRVETDVPLTPHTAMRQVRRDGGFVWIGLHEPTEDEFAGIAREFGLHPLAVEDAVQAHQRPKLERYDDSLFTVFKTVHYVDHDQLTANSEVVETGEVMCFTGRDFFITVRHGGQGSLRALRRRLQEDPELLLKGPSAVLHAIADHVVDGYIAVADAVQDDIDEVETEVFSPGRKGSPRGTDAGRIYQLKREVLEFKRAVAPLLRPMQLLSERPMRLVDPEIQKYFRDVADHVARVQEQVIGFDELLNSILQANLAQASVAQNEDMRKITSWAAIIAVPTMVCGVYGMNFDYMPETHWKFGYPLVLSVTVCICLGIHRTLKRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBN4</accession>
    <name>Q9FBN4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO5044</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629196.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973933.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5044"/>
    <dbReference type="GeneID" id="1100485"/>
    <dbReference type="KEGG" id="sco:SCO5044"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5124"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026758_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBN4"/>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="PhylomeDB" id="Q9FBN4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAC05889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="558" mass="60768" checksum="93BF08A61D89623E" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBW4</accession>
    <name>Q9FBW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7821</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031939.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7821"/>
    <dbReference type="GeneID" id="1103259"/>
    <dbReference type="KEGG" id="sco:SCO7821"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7931"/>
    <dbReference type="eggNOG" id="ENOG502ZIN3">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092035_1_0_11"/>
    <dbReference type="OMA" id="DACANDF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC03639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14261" checksum="27D59F83EBE3FD9C" modified="2001-03-01" version="1">MTYPEHPGTPADAAQTHPGAGTGRSNGLAVAALVLAILAVLLFWTVVGGVVLGLLALIFGIIGARRARGDRVPHRKMSIVAAVLGTLGVIASVVIIAIGASILNSDEFKDFDDCVQHADTQSERDACANDFEEDINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC06</accession>
    <name>Q9FC06_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative secreted peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO7176</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631234.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031481.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7176"/>
    <dbReference type="GeneID" id="1102614"/>
    <dbReference type="KEGG" id="sco:SCO7176"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7275"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007528_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FC06"/>
    <dbReference type="OMA" id="GERSHRT"/>
    <dbReference type="PhylomeDB" id="Q9FC06"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017296">
        <property type="entry name" value="Peptidase_S8A_SAM-P45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037852">
        <property type="entry name" value="Subtilisin_rel_SAV5721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176700" evidence="6">
        <location>
            <begin position="31"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="238"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC01576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1253" mass="130971" checksum="AA69B417EFEEDB89" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC42</accession>
    <name>Q9FC42_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7041</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631103.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972103.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7041"/>
    <dbReference type="GeneID" id="1102479"/>
    <dbReference type="KEGG" id="sco:SCO7041"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7145"/>
    <dbReference type="eggNOG" id="ENOG50349S0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126481_0_0_11"/>
    <dbReference type="OMA" id="DTLAHSD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="14324" checksum="A3325EC53CA20990" modified="2001-03-01" version="1">METPANDHPVTPAQRALDTLAETTETADNTAALDTLASSDVLVPVPDDANDQDAADPGMLALPVLEQQGGGQVVPVFTSEVEMADLLPYVSRYRMVPLGALAAQWPADDLSLSIDAGSEHRLTLTSDGVRTLLART</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC82</accession>
    <name>Q9FC82_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7104</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631165.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031434.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7104"/>
    <dbReference type="GeneID" id="1102542"/>
    <dbReference type="KEGG" id="sco:SCO7104"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7205"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114874_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9FC82"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="31373" checksum="A5FC432522AE5704" modified="2001-03-01" version="1">MEPVVDTMPIGELLDERRHLLDVAHWMLGSGIVAEHVIDEAYREWYALSEHQRDRIGAPRAWLTRVVGSISLARLAPSDPGRDPHGPEGSSGASGPALEDDLDALWAEALDALTPAERATLVLNEALGGAAGAPVGTAGPARRDRPGPVDTEPLDRARHSLRVRAARPTPPCVEDALVDAVRQACADEDADRLATLLHPDAVAFYDGGGKVRTLTRPVVGGPRVARSLLTLLARHPRTTVHTRPVNGRTGLVARYDGQVAAVICLDLAGSRVVQVWAVLNPDKLRSWNRPRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-02" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCD7</accession>
    <name>TAP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tripeptidyl aminopeptidase</fullName>
            <shortName evidence="2">Tap</shortName>
            <ecNumber>3.4.14.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tap</name>
        <name type="ordered locus">SCO1230</name>
        <name type="ORF">2SCG1.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves tripeptides from the N-termini of proteins. Does not cleave mono- or dipeptides, or N-terminally blocked peptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.-"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625518.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027660.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCD7"/>
    <dbReference type="SMR" id="Q9FCD7"/>
    <dbReference type="STRING" id="100226.SCO1230"/>
    <dbReference type="ESTHER" id="strco-TAP">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.002"/>
    <dbReference type="GeneID" id="1096653"/>
    <dbReference type="KEGG" id="sco:SCO1230"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1229"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="InParanoid" id="Q9FCD7"/>
    <dbReference type="OMA" id="LPCATWP"/>
    <dbReference type="PhylomeDB" id="Q9FCD7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000401061" evidence="2">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000401062" description="Tripeptidyl aminopeptidase" evidence="2 3">
        <location>
            <begin position="40"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="123"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q54410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01454.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="58536" checksum="01BA2E6F70B124DB" modified="2001-03-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCI0</accession>
    <name>Q9FCI0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4188</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628363.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029489.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4188"/>
    <dbReference type="GeneID" id="1099628"/>
    <dbReference type="KEGG" id="sco:SCO4188"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4252"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078241_0_0_11"/>
    <dbReference type="OMA" id="RPGQRMP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="33024" checksum="4BA3B7499DD07E0E" modified="2001-03-01" version="1">MVVEPEHAPVNGRERPQRPQATHREVADELRARIRSGRLRPGQRMPTQAQLAEEFGVERGAVRQALRILQSERLLTNVSKGSPATVAPDPYGPQSGPEARPMPTTVALASRIAAAFAAEHVEIDALCLTSVSLTLALGEPLSQIHAGRLKPAKVDVRVLLPSGDIDLAFPVAVSGGAAGGPVHERWLAMRNAQGQVLRHNLLSLRATHGIDVRVSFRALPFTPPVKLYVLNGSEALFAYYTLGRREQEIDHEQLEMYDAEGIRSTLFAFEQGGGLRDGVFVKQSRLWFDALWGTISSELVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL0</accession>
    <name>Q9FCL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sulfurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5178</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629326.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973798.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5178"/>
    <dbReference type="GeneID" id="1100619"/>
    <dbReference type="KEGG" id="sco:SCO5178"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5261"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_1_11"/>
    <dbReference type="InParanoid" id="Q9FCL0"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="PhylomeDB" id="Q9FCL0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC01308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="392" mass="42635" checksum="FD4FEAB91DF6E78D" modified="2001-03-01" version="1">MSLPPLVEPAAELTVDEVRRYSRHLIIPDVGMDGQKRLKNAKVLAVGAGGLGSPTLMYLAAAGVGTLGIIEFDEVDESNLQRQVIHSQADIGRPKAESARDTIQGINPLVDVILHQERLEADNVMDIFSQYDLIVDGTDNFATRYLVNDACVLLNKPYVWGSIYRFDGQASVFWSEHGPCYRCLYPEPPPPGMVPSCAEGGVLGVLCASIGSIQTNEAIKLLQGIGEPLVGRLMIYDALEMTYRQVKVRKDPNCAVCGENPTVTELIDYEAFCGVVSEEAQAAAADSTITPKQLKEWIDDGENIELIDVREPNEFEIVSIPGARLIPKNEFLMGSALENLPQDKKIVLNCKTGVRSAEVLAVLKSAGFSDAVHVGGGVIGWVNQIEPEKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3G1</accession>
    <name>Q9K3G1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO1280</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625567.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027689.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1280"/>
    <dbReference type="GeneID" id="1096703"/>
    <dbReference type="KEGG" id="sco:SCO1280"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1280"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024186_5_0_11"/>
    <dbReference type="OMA" id="PGNRMVT"/>
    <dbReference type="PhylomeDB" id="Q9K3G1"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071731">
        <property type="term" value="P:response to nitric oxide"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="11">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB99160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="413" mass="44537" checksum="2C841BDA772FCB3D" modified="2000-10-01" version="1">MRPDFGTDGRLPSALSMGTADVAFHLATGGNPVPLAFTFGFEGRAPTLDSVRARVAERVHHVPALRYRIARDRRKFRRVDRIAVDRHVHEAWLPEDTDGSATSRLMLSRPMSTDDRPPWDVWLVHGPAERHTLVYRTDHTFQDGMGAAYTARALLGDHPEGGPAPQRPARPTAHGLADALGEVVAAFRAPTPKPAFDGDFTGRVDVCHADTPLARLRAIARAHGGTVTDVYLAALSHAVRTWYLKDTGSAHPPLPVSIPMSVRAPGEEYAPGNRMVTARLLLPCDEESPQRALARVVAGTGRLRESRRRDAMRLLLSASPRALGATVGTRLVRGAFVAGPVSSVNFGTALVHQGVAARRSAVFAGVASGIRCVTTLTSQHDTACLTVVHDEALATADELPDLWLAALLELERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J5</accession>
    <name>Q9K3J5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4825</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628981.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974147.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4825"/>
    <dbReference type="GeneID" id="1100266"/>
    <dbReference type="KEGG" id="sco:SCO4825"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4901"/>
    <dbReference type="eggNOG" id="ENOG5033CNM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087301_1_0_11"/>
    <dbReference type="OMA" id="RQWPLLT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB97428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="18883" checksum="7D3115BEF395709D" modified="2000-10-01" version="1">MPAEDTNAERPGDARAPEDGAPRASQASGEPDGITVRDPVSAPDAEGRPRRTTRRFPLFTRDTARPEGGGRAAPGDAPAPARQWPVLTVTLLVGVGLLLTALDVFRWGLVLVGAALLLGAALRWTMPRVGMLAVRSRFTDIATYGVLGLSIALLALMAQPNPVLEIPFLKDTLHFTVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3L9</accession>
    <name>RLMG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.174</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2G1835 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmG</name>
        <name type="ordered locus">SCO1041</name>
        <name type="ORF">SCG20A.21</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10218"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmG family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB96026" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.174" evidence="1"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96026.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625336.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027537.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3L9"/>
    <dbReference type="SMR" id="Q9K3L9"/>
    <dbReference type="STRING" id="100226.SCO1041"/>
    <dbReference type="GeneID" id="1096464"/>
    <dbReference type="KEGG" id="sco:SCO1041"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1036"/>
    <dbReference type="eggNOG" id="COG2813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040288_4_0_11"/>
    <dbReference type="InParanoid" id="Q9K3L9"/>
    <dbReference type="PhylomeDB" id="Q9K3L9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052916">
        <property type="term" value="F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01859">
        <property type="entry name" value="23SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017237">
        <property type="entry name" value="rRNA_m2G-MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF5">
        <property type="entry name" value="PTHR47816:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037565">
        <property type="entry name" value="RRNA_m2G_Mtase_RsmD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000366528" description="Ribosomal RNA large subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="377" mass="41282" checksum="4B0B9358A11F2419" modified="2009-03-24" version="2">MTTPWGERVLSRFPEDPRDRLRAWDASDEYLLGHLAEREVPLSGTVVVVGDRWGALVTALAPHRPVQITDSHLAREATRVNLERSGVEPGSVRLLTTQDPPPDRVDVLLVRVPKSLALLEDQLLRLAPALHEGTVVVGTGMVKEIHTSTLRLFERIVGPTRTSLAVKKARLIFAEPDPALKRPANPWPLGYRLPDDVGRLSGRPVVNHAGVFCADRLDIGTRFFLRHLPAPGRFRRVVDLGCGNGVVGTAVSLADPDAELLFTDESFQAVASARATYRANEVAGQAEFRVGDGLAGVPDGSVDLVLNNPPFHSHQATTGATAWRMFTGARRVLRPGGELWVVGNRHLGYHVRLRRLFGNSELVAGDRKFVVLKAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3T7</accession>
    <name>Q9K3T7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3126</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627343.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028783.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3126"/>
    <dbReference type="GeneID" id="1098560"/>
    <dbReference type="KEGG" id="sco:SCO3126"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3190"/>
    <dbReference type="eggNOG" id="ENOG503409A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685612_0_0_11"/>
    <dbReference type="OMA" id="SWGTAQH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="17286" checksum="276B008B10DA909E" modified="2000-10-01" version="1">MIPAMPASAAAARPRQASSVSSVLLRFGRVASMGTVTALILIAGVWASWGTAQHVLLTKGREQGTVEVTRCGGGTCSGPYSPVSAGSQARERVVLEDSVAVAKGRTYSVVLKPGSADAVRSGPAGVLYAWVPLGGALLLASVVVAGGLRRTRAGWVMAGAGVALLTAAFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C5</accession>
    <name>Q9K4C5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5386</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973611.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5386"/>
    <dbReference type="GeneID" id="1100826"/>
    <dbReference type="KEGG" id="sco:SCO5386"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5466"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_8_0_11"/>
    <dbReference type="OMA" id="HIRGDHA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="107" mass="11515" checksum="B1F254CEE483ECF3" modified="2000-10-01" version="1">MHIRGDHVELVVGGRLDVRSAADARTVLHSAVDDGVGDLVLDLSELDSWDATGLGVIMGAHRRAGRCGRRLVLRGVPPQMQRLLVATRLHRILAIEGGIGVETLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4G7</accession>
    <name>Q9K4G7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628347.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029482.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4171"/>
    <dbReference type="GeneID" id="1099611"/>
    <dbReference type="KEGG" id="sco:SCO4171"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4236"/>
    <dbReference type="eggNOG" id="ENOG50341VK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080442_0_0_11"/>
    <dbReference type="OMA" id="AMICSAY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="25995" checksum="1C26A641D0BDD89F" modified="2000-10-01" version="1">MSGQRTRRGRATAAAGGLLLAVVVGAVGYTVDTVKDADRASGAPVWTPPGAPTDDEKEAPATGLSGALVPYRSDGWTRGPDLGEFGADAALTGAHAAALTKESLSDLPRSQRKELEKEIDRLHITGVAMRSYATTGGLHSGEQTGAATLSIVLTRMDRRAARSGASDRNEAFESLEVFEAGPSIKGHKNARCYRLPGESDEELDVMFCTASQGDVLVSATAEGVRPFGAEGVAALLTEQLDRLGETGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK3</accession>
    <name>Q9KXK3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626564.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976496.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2317"/>
    <dbReference type="DNASU" id="1097751"/>
    <dbReference type="GeneID" id="1097751"/>
    <dbReference type="KEGG" id="sco:SCO2317"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2354"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079357_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KXK3"/>
    <dbReference type="OMA" id="YHEVEGG"/>
    <dbReference type="PhylomeDB" id="Q9KXK3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="26932" checksum="80418A2D2AC4CBB9" modified="2000-10-01" version="1">MLTVDFSRFPLAPGDRVLDLGCGAGRHAFECYRRGARVVALDQNAEEIREVAKWFAAMEEAGEAPAGATATAMEGDALALPFPDESFDVVIISEVMEHIPDDKGVLAEMVRVLKPGGRIAITVPRYGPEKVCWTLSDAYHEVEGGHIRIYRADQLLTRIREAGLKPYGTHHAHALHSPYWWLKCAFGVDNDKALPVRAYHKLLVWDIMKKPLATRVAEQALNPLIGKSFVAYATKPHLPPVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXP7</accession>
    <name>Q9KXP7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625783.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977323.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1503"/>
    <dbReference type="GeneID" id="1096929"/>
    <dbReference type="KEGG" id="sco:SCO1503"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1512"/>
    <dbReference type="eggNOG" id="COG4768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132014_0_0_11"/>
    <dbReference type="OMA" id="FSYGVRR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="149" mass="15488" checksum="F42637EB2F116D13" modified="2000-10-01" version="1">MHTVSGGEVAGILVAVFWAILVSFLAVALARLAQTLRTTTKLVADVTDQAVPLLADASAAVRSAQTQIDRVDAIASDVQEVTSNASALSTTVASTFGGPLVKVAAFGYGVRRALGGRKEDMSAPADQARRTVIVGRTLPAARRTKRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXW4</accession>
    <name>Q9KXW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tellurium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4277</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628449.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974698.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4277"/>
    <dbReference type="GeneID" id="1099717"/>
    <dbReference type="KEGG" id="sco:SCO4277"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4345"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KXW4"/>
    <dbReference type="OMA" id="FFNNKQT"/>
    <dbReference type="PhylomeDB" id="Q9KXW4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="191" mass="20344" checksum="42BE1C979DF808EA" modified="2000-10-01" version="1">MAVSLSKGGNVSLTKEAPGLTEVTVGLGWDVRTTTGTDFDLDASAIAVNTQGKVYSDAHFVFFNNKQTPDNTIVHTGDNRTGEGAGDDEAINVNLAGLPADIEKIVFPVSIYDAENRSQNFGQVRNAYIRILNQAGGAEIARYDLSEDAATETAMVFGELYRNGAEWKFRAVGQGYASGLTGIAQDFGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY94</accession>
    <name>Q9KY94_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative septum site-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5008</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629160.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029999.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5008"/>
    <dbReference type="GeneID" id="1100449"/>
    <dbReference type="KEGG" id="sco:SCO5008"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5087"/>
    <dbReference type="eggNOG" id="ENOG5034AS9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099056_1_0_11"/>
    <dbReference type="OMA" id="QIGLIAY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="13670" checksum="9D50D7F42F81F437" modified="2000-10-01" version="1">MPYSRRKKPTGTPYRRGARAGDRGQVAIEYLGFLPILVLVGMAAVQLGLIAYTAQQAGTAARAGARSASLRESAETACAAAVSSWLADGTDCPASYGGDEVTVTATVEIPSIVPGWEFDPATRTATMPLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYY4</accession>
    <name>Q9KYY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC-transport protein, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7545</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAB90903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631589.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031738.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7545"/>
    <dbReference type="GeneID" id="1102983"/>
    <dbReference type="KEGG" id="sco:SCO7545"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7659"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9KYY4"/>
    <dbReference type="OMA" id="KGFENHW"/>
    <dbReference type="PhylomeDB" id="Q9KYY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB90903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="270" mass="29725" checksum="B77F7F0550189C25" modified="2000-10-01" version="1">MTSTPAKISVQHVTKTFSLGRETFTALDDVSLDIANHEFVTVVGPSGCGKSTLMNILAGLEAPTSGRALVDGAPVSGPGPERGVIFQQYALFPWLTVRQNVEFGLRTTGVPKRERRARAEHFIELVGLERFADALPKTLSGGMRQRCAIARAYAVDPSILLMDEPFGALDALTRVKLQEQLLKTWSQDRRTVLFITHDVDEAVFLANRVVVMAARPGRVYDVVDVDPAIERDEAFRLSPEFAALRNRVWRSVYHQEGRTAALSGSHSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ47</accession>
    <name>Q9KZ47_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7085</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631146.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972059.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102523"/>
    <dbReference type="KEGG" id="sco:SCO7085"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7187"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191574_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="86" mass="9372" checksum="177CC146152B7F10" modified="2000-10-01" version="1">MELGKETSANSGWRTALRKYMEMDERGCFNADPLDTTYEETLDQVATGRAVGVVQVASVLSEPRAAAPELPRPLREHLIQAVGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZF8</accession>
    <name>Q9KZF8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6995</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631060.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972149.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6995"/>
    <dbReference type="GeneID" id="1102433"/>
    <dbReference type="KEGG" id="sco:SCO6995"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7097"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044990_0_0_11"/>
    <dbReference type="OMA" id="HSTYDAC"/>
    <dbReference type="PhylomeDB" id="Q9KZF8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="198"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="477" mass="50792" checksum="316269D38CF629FB" modified="2000-10-01" version="1">MAPQRFREQFDQIQRSMPDVPLAMGPDDSAEFFYEKGVVLARDGEEARLVEDTVRDHFTTMAGLAPDHVRRASPESNRTGITRIQVADPGEGARDGDPTVAHALRSLRTMEGRAGRRLISRNHVVSIAVNACPGDEPVPVPLSEPPNPAADGTPYDAGTAVGVLVIDTGLMHDYRSYPLLAHTDGDAQIRECDDDGVLCQYVGHGTFIAGLVAAVAPNTDVTVSNTLNDAGAILESELGEKLFEAVDSGGWPEVLSLSAGTSNGRTDGLLGVHAFMEELRDQRTLLVAAAGNNASATPFWPAAYATLPGWEDSVLSIGALRSDGEFGACFSNHGGWVRAYAPGERLTSALTGFGTPVPYVYQHSTYDACRFGFTYACTCQYPRHNGVLSEPGEAPAKPDQVMFEGHAQWSGTSFATPVVAGLVASRMTAHKETDPRAAGRQLLAANTEYAEVRGAHVPALLPPTWRPVPVDPSEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZQ2</accession>
    <name>Q9KZQ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2901</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36124">
        <property type="entry name" value="T36124"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627127.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028654.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2901"/>
    <dbReference type="GeneID" id="1098334"/>
    <dbReference type="KEGG" id="sco:SCO2901"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2960"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_11"/>
    <dbReference type="InParanoid" id="Q9KZQ2"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="PhylomeDB" id="Q9KZQ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16848" checksum="C46EA2747CDEFBEA" modified="2000-10-01" version="1">MSERLQPGDPAPAFTLPDADGNEVSLSDHQGRKVIVYFYPAALTPGCTKQACDFTDNLELLTGAGYDVIGISPDKPEKLAKFREAESLKVTLLADPDKKVLDAYGAFGEKKNYGKTYMGVIRSTIVVDEQGKVERALYNVRATGHVAKIIKDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZY3</accession>
    <name>Q9KZY3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative merR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4443</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628610.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029656.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4443"/>
    <dbReference type="GeneID" id="1099883"/>
    <dbReference type="KEGG" id="sco:SCO4443"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4513"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_2_2_11"/>
    <dbReference type="InParanoid" id="Q9KZY3"/>
    <dbReference type="OMA" id="SMESDGP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="31600" checksum="D0958954A543A25B" modified="2000-10-01" version="1">MDDGVDDCVDDGAHDALLTIGAFAARARLSAKALRLYDRLGLLAPAHVDEATGYRYYRAGQAERARLVALLRRLDMPLARIAEVVRADGDRAAGLLDGYWADVEARVAGQRTLVAYLRGRLSGRDSEVYGEFVVETVDVPEQVVISETRHTLASELPAWIGASLGRLEEAARGCGGVTAAPYVVYHSDVSMESDGPAESCVPVADGAAARAWSEERGRAWQTRVRVEPAGRLAYTRITKAQVAYPQILAAFGAVEEWIAAHGLTVAGPCREVYFADWEAAGPGDPVCDVAFPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0J3</accession>
    <name>Q9L0J3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4672</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628832.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029805.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4672"/>
    <dbReference type="GeneID" id="1100113"/>
    <dbReference type="KEGG" id="sco:SCO4672"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4744"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491400_0_0_11"/>
    <dbReference type="OMA" id="DFHEYMG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176803" evidence="3">
        <location>
            <begin position="28"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="403"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="589" mass="61743" checksum="1237F9589951A245" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0P3</accession>
    <name>Q9L0P3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4248</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628422.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974727.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4248"/>
    <dbReference type="GeneID" id="1099688"/>
    <dbReference type="KEGG" id="sco:SCO4248"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4311"/>
    <dbReference type="eggNOG" id="ENOG5032RVA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0P3"/>
    <dbReference type="OMA" id="CEGLGCE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB77342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="15182" checksum="12BA321C34B7A1A6" modified="2000-10-01" version="1">MTRKDPGSSIWFSLAIDGESLGYFNGCEGLSTQVEVEQRQEGGNNGFVWQLPTRVTYSNIRLTRPLTPDTAKVAKWISSVQTGIQRPTAQISALRADGSLVARWGLIDVLPVSWQGPSLDPGSASVANEVLEIAHHGFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0S6</accession>
    <name>Q9L0S6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4518</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029704.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4518"/>
    <dbReference type="GeneID" id="1099958"/>
    <dbReference type="KEGG" id="sco:SCO4518"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4590"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609584_0_0_11"/>
    <dbReference type="OMA" id="WEFIREN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB77309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="449" mass="46597" checksum="407A47A4AF16E1EB" modified="2000-10-01" version="1">MSSEKYPNLGFDPAPGDLEAVRDLVKAVGRVTSGSDTAQTELSKMGTVDGIWAGKAATSFQDTYSPVPPYLKKALGSLDTAHRALSGWETQLDGFQTRARKLEEEAAEAARKVNSAQAAVNSLPSSAEGLSDADEKKHEKDAKEKKKSLETATGELTAIRSRAHSLQSEHGQAAADVTRLVKGAADDAPPEPGWFEEALDAVGDLLSDAWDTITDPNFWKLIGDVLADIAMVVGVLAIFFSGLGVAAFIIAGLALAFHLAAKAGGADVTWETIAWDAVGVFAGGLSLAGARLAQSGRALVNAGRELRLSSGFMKALGNVRFGNLLNGLRGLPSGVANSARGLGMAGKGWSFVAAGTAVDKAATWTGAALAIGSNMHNGTWDQGRWTDGEFKIGDIPVVGPFMDYFGATDGGEVMAPGPASPTFDTQTALSSSGNTFTKHLDPSQMGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L111</accession>
    <name>Q9L111_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1448</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625729.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977377.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096874"/>
    <dbReference type="KEGG" id="sco:SCO1448"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1458"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L111"/>
    <dbReference type="OMA" id="MSGLHGM"/>
    <dbReference type="PhylomeDB" id="Q9L111"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB76870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="403" mass="40933" checksum="C67E9DBD94676BE1" modified="2000-10-01" version="1">MNTGTYGRREVRHARYAVAAVFAVHGSVTGSFATRVPWIQDHAGVSAGQLGLALAFPALGASLAMPLAGRVTHRFGARAALRGLLALWTLALALPSLAPNLLTLCLALFVYGATAGMSDVAMNALGVEIETRLDKSIMSGLHGMWSTGALIGSAAGTLAAHLGTDARTHHLLAAAVLTVTGLVACTWVLDLQPAEDEDPPPRFALPPKSALLIGAVGFCAVFAEGASLDWSAVYLRDELETSAGLAAACTTGFTLTMALARLAGDKVVDRFGAVRTVRVSGVLATLGGLLVVVGGHPAVAMTGFALMGLGIAVVVPLCFAAAGRAGSNPSLAIAGVATITYTSGLVAPSAIGGLAQATSLVVSFGLVTLLACCLVVFARVLRAGDRNRPKISPPVAEVPGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L115</accession>
    <name>Q9L115_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1444</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB76866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625725.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1444"/>
    <dbReference type="CAZy" id="CBM5">
        <property type="family name" value="Carbohydrate-Binding Module Family 5"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="1096870"/>
    <dbReference type="KEGG" id="sco:SCO1444"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1454"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_13_0_11"/>
    <dbReference type="InParanoid" id="Q9L115"/>
    <dbReference type="OMA" id="VNDGPAY"/>
    <dbReference type="PhylomeDB" id="Q9L115"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CBM_fam5/12"/>
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        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009470">
        <property type="entry name" value="Chi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="ChiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176809" evidence="5">
        <location>
            <begin position="40"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="78"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB76866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="791" mass="84456" checksum="601CDDBE1887B68C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1H2</accession>
    <name>Q9L1H2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2605</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626842.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028451.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1098039"/>
    <dbReference type="KEGG" id="sco:SCO2605"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2650"/>
    <dbReference type="eggNOG" id="ENOG502ZC50">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097508_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1H2"/>
    <dbReference type="OMA" id="KGFDHES"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB75386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25694" checksum="785A554B8CFCF0A7" modified="2000-10-01" version="1">MTVHDVARTLPGIPALHDLCRSLSMAEAIVNPGGEGRHHIFNRSWSQTEELASMRNGSGDEFDIVFSAAGAYVRGFAHESPLSPYHQRDDYEPWPGVVDAVPAAFQRYVHEPLFTDEDGTPVVTVCLWRHAVADRWETGDIDFPEGHPDPDGTTGLFGLLTRPEPEAFKTFAEDYYETAVSLEALRHIYDLRPLDQAVIAMLSPLAPVTDVVQDALAIGYPISPALRTGPRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="149" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1K9</accession>
    <name>Q9L1K9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO5435</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629573.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030246.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5435"/>
    <dbReference type="GeneID" id="1100875"/>
    <dbReference type="KEGG" id="sco:SCO5435"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5516"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_11_1_11"/>
    <dbReference type="InParanoid" id="Q9L1K9"/>
    <dbReference type="OMA" id="HYQNGWL"/>
    <dbReference type="PhylomeDB" id="Q9L1K9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="296"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB72411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="552" mass="57696" checksum="3E6FC91BC487C074" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Y3</accession>
    <name>Q9L1Y3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2652</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626888.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028484.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2652"/>
    <dbReference type="GeneID" id="1098086"/>
    <dbReference type="KEGG" id="sco:SCO2652"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2699"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_4_0_11"/>
    <dbReference type="InParanoid" id="Q9L1Y3"/>
    <dbReference type="OMA" id="GCLVEQA"/>
    <dbReference type="PhylomeDB" id="Q9L1Y3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB71827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="15736" checksum="3892BB2EA4A36DC7" modified="2000-10-01" version="1">MSANSRLTIAAHALAWIGLYQRQGHEVATSEQIAASANTNPVVIRRLLGELRRSGLVESRRGVGAGWSLARELGSMTLLDVYEAVEPGPLFAMHRTTPDQGCVVGHGIQPAMRDVYEGIEETVRHELARVTLEDVLRNVLATPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L233</accession>
    <name>TDH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="1">TDH</shortName>
            <ecNumber evidence="1">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdh</name>
        <name type="ordered locus">SCO6799</name>
        <name type="ORF">SC1A2.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="1"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630871.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031190.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L233"/>
    <dbReference type="SMR" id="Q9L233"/>
    <dbReference type="STRING" id="100226.SCO6799"/>
    <dbReference type="PRIDE" id="Q9L233"/>
    <dbReference type="GeneID" id="1102238"/>
    <dbReference type="KEGG" id="sco:SCO6799"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6909"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_11"/>
    <dbReference type="InParanoid" id="Q9L233"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="PhylomeDB" id="Q9L233"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000160860" description="L-threonine 3-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <sequence length="342" mass="36458" checksum="25BC561F49C0E9E1" modified="2000-10-01" version="1">MKALVKENAEPGLWLADVPEPTIGSGDVLIKVLRTGICGTDLHIRAWDGWAQQAIRTPLVVGHEFVGEVVDTGRDVTDIKAGDRVSGEGHLVCGKCRNCLAGRRHLCRATVGLGVGRDGAFAEYVALPASNVWVHRVPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGLMAAAVARHAGARNVVITDVSEERLELARKVGATLALNVSDATIADGQRELGLREGFDIGLEMSGRPEAMRDMIANMTHGGRIAMLGLPAEEFPVDWARVVTSMITVKGIYGREMFETWYAMSVLLEGGLDLAPVITGRYSHRDFEAAFADAASGRGGKVILDWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L243</accession>
    <name>Q9L243_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2678</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626913.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028507.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2678"/>
    <dbReference type="GeneID" id="1098112"/>
    <dbReference type="KEGG" id="sco:SCO2678"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2733"/>
    <dbReference type="eggNOG" id="COG1877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101802_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L243"/>
    <dbReference type="OMA" id="LHWKTRP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB71216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18374" checksum="E2686C8CCB9EE593" modified="2000-10-01" version="1">MTSSSERPLLFLDVDGPLIPFGSSAGHSEIAAASSTTADQGNPLLARLDPGIGERLTALGCRLVWATTWREEANEVIAPRIGLPRLPVLEWPDADAGGTPQGLHWKTRPMVEWAAGRPFIWVDDEISAIDRLWVDASHPGPSLLHRVEPAKGLSGTDFGALAAWLDTVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2E1</accession>
    <name>Q9L2E1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2478</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626720.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028374.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2478"/>
    <dbReference type="GeneID" id="1097912"/>
    <dbReference type="KEGG" id="sco:SCO2478"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2520"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_11"/>
    <dbReference type="InParanoid" id="Q9L2E1"/>
    <dbReference type="OMA" id="DTVSFHN"/>
    <dbReference type="PhylomeDB" id="Q9L2E1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="21062" checksum="889E354B89B94DDA" modified="2000-10-01" version="1">MNTTTAPLRVTLLVGSNRHGRFGPVVADWLLDHLRAHDDLVPEVVDVAGTALPTTLAPTPEATAALAEITPKLADADAFVVLTPEYNHSFPAGLKNVIDWHFTEWRAKPVGLVSYGGLAGGLRAAEHLRQVFAELHAVTVRDTVSFHNAGASFDGEGRLRDPSGPDAAAKTMLDQLVWWGRALREAKEKRPYDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2E8</accession>
    <name>Q9L2E8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2471</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626713.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028370.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2471"/>
    <dbReference type="GeneID" id="1097905"/>
    <dbReference type="KEGG" id="sco:SCO2471"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2512"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056929_3_0_11"/>
    <dbReference type="InParanoid" id="Q9L2E8"/>
    <dbReference type="OMA" id="LGTHPAM"/>
    <dbReference type="PhylomeDB" id="Q9L2E8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB69759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="27959" checksum="C3AD34998126034D" modified="2000-10-01" version="1">MTSSRTTAATGGTPALVVVAHGSRDPRALSTVRALLDRVRALRPALPVHLGHVELNEPLLPDTLTALGDGAAVLVPLLLSRGHHVKRDIPEMAAASPARTRVAGPLGPHSLLVDALQARLTEAGWPTHPGPEHAVVLASAGSRDPESRADTARTAAALAARLGVPVVPAYASAAAPTVPEAVRALTDRGHRRIALASCFTAPGRFATQCAAAAPWIASEPLGTHPAMARLLLHRYDRALGRGGASNAGREARDGTTCGSAAGARPAATEPALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2K6</accession>
    <name>Q9L2K6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0698</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625004.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0698"/>
    <dbReference type="GeneID" id="1096121"/>
    <dbReference type="KEGG" id="sco:SCO0698"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.685"/>
    <dbReference type="eggNOG" id="ENOG5031TE3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160058_1_0_11"/>
    <dbReference type="OMA" id="SYTLCVM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033457">
        <property type="entry name" value="DUF5133"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17196">
        <property type="entry name" value="DUF5133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="121" mass="12805" checksum="DC4DA6F448670731" modified="2000-10-01" version="1">MNARIRSIAGEGGHGAIVTAGAGHTQRKSREGRFVLEPDPKVVRELLTRYATLRIAQAERPRPAVTRELTDVSYTLCVMLATTSVHEAVARADALLLAKGRATPEACPADADGESGLSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDH2</accession>
    <name>Q9RDH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2755</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626986.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028564.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2755"/>
    <dbReference type="GeneID" id="1098189"/>
    <dbReference type="KEGG" id="sco:SCO2755"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2811"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RDH2"/>
    <dbReference type="OMA" id="FGAPMQR"/>
    <dbReference type="PhylomeDB" id="Q9RDH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="24152" checksum="165FB9C797F366AB" modified="2000-05-01" version="1">MTFTLKAPVLEGALVRLEPLDQRHAADLARAAAEDRATYAFTWVPGPDEVGAYIDFQLARAATGRLAPYAQVSRATGRAVGTTAYWEPRSWLTDDALDAVEVGFTWLARSAQGTGVNAEAKLLLLRHAFEVWEVSRVDLKTDARNQRSRAAIEKSGARFEGVLRNWSRSSVPGEEGRLRDSAIYSITSAEWPECAKRLEHRVRSAVARPAPAPAALTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI37</accession>
    <name>Q9RI37_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0211</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37040">
        <property type="entry name" value="T37040"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624544.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026929.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0211"/>
    <dbReference type="GeneID" id="1095635"/>
    <dbReference type="KEGG" id="sco:SCO0211"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.182"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119970_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9RI37"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="24931" checksum="A927C944E16B34AF" modified="2000-05-01" version="1">MRGARARGQRAGGHRLPVGGRRPDHRVRRPGGAGSARDGIARDVHDLVIQRLFAGALSPQPALGRVTGRPKASERIQRVVADLDDTIKVIRSTIHALRESDRQTGTALRSRLVGVTDRAAEVLGFAPALRMTDLLDTAVPAEHGAHLLAVLEEARSNAARHARASAVDVGVDVAGAVTRLRVADNGRGIAPRMTRRSGLANLRGRAEALGGTLDLSAEEGGGTLARWTVPLPASAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJR0</accession>
    <name>Q9RJR0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycerone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0580</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624892.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027218.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0580"/>
    <dbReference type="GeneID" id="1096003"/>
    <dbReference type="KEGG" id="sco:SCO0580"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.561"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RJR0"/>
    <dbReference type="OMA" id="TALNMNG"/>
    <dbReference type="PhylomeDB" id="Q9RJR0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="7">
        <location>
            <begin position="7"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="6">
        <location>
            <begin position="385"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="593" mass="60049" checksum="6E3206465632E7DA" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJU0</accession>
    <name>Q9RJU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible DNA-binding protein (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624693.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027060.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0370"/>
    <dbReference type="CAZy" id="GH106">
        <property type="family name" value="Glycoside Hydrolase Family 106"/>
    </dbReference>
    <dbReference type="GeneID" id="1095793"/>
    <dbReference type="KEGG" id="sco:SCO0370"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.346"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281434_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJU0"/>
    <dbReference type="OMA" id="GFWDDEP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176913" evidence="2">
        <location>
            <begin position="33"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1134" mass="121690" checksum="89B689CD455C4520" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJU2</accession>
    <name>Q9RJU2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative insertion element transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0368</name>
        <name evidence="3" type="ordered locus">SCO7803</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624691.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631833.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027058.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0368"/>
    <dbReference type="GeneID" id="1095791"/>
    <dbReference type="GeneID" id="1103241"/>
    <dbReference type="KEGG" id="sco:SCO0368"/>
    <dbReference type="KEGG" id="sco:SCO7803"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.344"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_15_0_11"/>
    <dbReference type="OMA" id="WKRAYER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="130"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="36544" checksum="65546BB9CA1DBEE9" modified="2000-05-01" version="1">MVHRNAPLTETGRLRLARCVVEDGWPVRRAAERFQVSHTTASRWARRYRQLGVTGMSDRSSRPHHQPRRTAAAVEEHVLRLRREHRIGPLRLAVRCGIAASTAHRILVRHGLPPLAALDRATGEPVRRYERARPGELVHIDVKKLGRIPDGGGHKTLGRAEGHRSRTNGAGWAYLHTALDDHSRIAYTEDLPDETAPTCAAFLVRATAYFASLGIRIERVLTDNAWAYSKNTWRNTCRDLDISPRWTRPWRPQTNGKVERFHRTLLDEWAYQKPYTSDHERREAFTHWLHWYNYHRPHTGIGGHTPASRGTNLSEQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK17</accession>
    <name>Q9RK17_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MbtH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0489</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36407">
        <property type="entry name" value="T36407"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624806.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978376.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0489"/>
    <dbReference type="GeneID" id="1095912"/>
    <dbReference type="KEGG" id="sco:SCO0489"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.469"/>
    <dbReference type="eggNOG" id="COG3251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181321_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RK17"/>
    <dbReference type="OMA" id="QYSLWPG"/>
    <dbReference type="PhylomeDB" id="Q9RK17"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="70" mass="7758" checksum="781E17FE17249598" modified="2000-05-01" version="1">MSTNPFDDADGRFLVLVNDEGQHSLWPAFAAVPGGWTTVFEENTRDACLAYVEANWTDLRPRSLARTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK31</accession>
    <name>Q9RK31_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0685</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB60466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624993.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027293.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0685"/>
    <dbReference type="GeneID" id="1096108"/>
    <dbReference type="KEGG" id="sco:SCO0685"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.671"/>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139202_1_1_11"/>
    <dbReference type="OMA" id="GGDHETT"/>
    <dbReference type="PhylomeDB" id="Q9RK31"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14035" checksum="DC431E51C8EFCCB9" modified="2000-05-01" version="1">MPGIDESLLEAMRLPGARGASLVDWISGLALGAVGEAPGGDWEATAAETAELGRHVAESGSLAAAGTAGGTVEPGKEPPVEDLITTTGDAYHLLRFVSTPFDSTVFLHLWLDRNDGNLALARIRLAEMADRLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ5</accession>
    <name>Q9RKQ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FecCD-family membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2273</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50582">
        <property type="entry name" value="T50582"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626521.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028242.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2273"/>
    <dbReference type="GeneID" id="1097706"/>
    <dbReference type="KEGG" id="sco:SCO2273"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2310"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_11"/>
    <dbReference type="InParanoid" id="Q9RKQ5"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="PhylomeDB" id="Q9RKQ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033214">
        <property type="term" value="P:siderophore-dependent iron import into cell"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB61719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="363" mass="37362" checksum="DD898D399E2A27B4" modified="2000-05-01" version="1">MTVRDKPVRAPAPADPAAPRARRTTAWLLTATLAAGLLVLVPVAAGTGAYPIPVGDVLGSLLHRAGLGGTELDRVAESVLWNVRFPRIVLALLVGASLGCAGALMQGVFGNPLAEPGVIGVSSGAAVGAVGAIAFGLNFLGTWTVSVFAFASGLVTVLVVYAMSRSGGRTEVVTLILTGIAVNAFAGALIGLFLFFADTAAVNQITFWQLGSLAQATWPKVLAVLPCAALGLGLAPLYARRLDLLALGERPARHLGVDVERLRIVLVLVIALLTAAAVSVAGVIGFVGLVVPHLLRMTAGPGHRFLIPGSALLGALVLLAADLAARTVAQPAELPLGVLTALLGSPFFFWLLRRTRRRQGGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2B0</accession>
    <name>Q9S2B0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO1720</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36742">
        <property type="entry name" value="T36742"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625993.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027939.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1720"/>
    <dbReference type="GeneID" id="1097151"/>
    <dbReference type="KEGG" id="sco:SCO1720"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1737"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S2B0"/>
    <dbReference type="OMA" id="AQDTHRG"/>
    <dbReference type="PhylomeDB" id="Q9S2B0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB50935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="28409" checksum="BDF7DC0324ADD7FF" modified="2000-05-01" version="1">MSTVTTGPHGSAYGLAYDGAALLGRQLRRARNNPGLLILTQTMPITMLLFFGYVFGSALAMPGEEYRAFLVPGLLVATAANGIMTGMFQAAQDTHRGVTDRLRTLPVSRAAVPLGQSVADVLVTAAGTVPLLLVGLAVGWRVEGGALRAVGALGLLLLFRFATTWIGIFLGLLTRNEEAAGQLGGATFILPLLSNAYIPTDGLPGWLRTLAEWNPISAVTTALRDLFGNAPVPDGAAWPVTHPVAGSLAWCAVLLAVFVPLAVRRYAHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX05</accession>
    <name>Q9WX05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3329</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36277">
        <property type="entry name" value="T36277"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627539.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028912.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3329"/>
    <dbReference type="GeneID" id="1098763"/>
    <dbReference type="KEGG" id="sco:SCO3329"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3389"/>
    <dbReference type="eggNOG" id="ENOG5033Q0W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092811_0_0_11"/>
    <dbReference type="OMA" id="WVCGAGQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031423">
        <property type="entry name" value="Phosphatase_SCO2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15698">
        <property type="entry name" value="Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="28514" checksum="1E438D80BC8ACFCC" modified="1999-11-01" version="1">MLTRGALRAHLLDVRLAGVVATSREVSLRSYRLFAARDPRVLIGIDPERDWGPRELLGLMAERCGVSADPRDVSGQDVIDPDRTLAALDAFAGRLAAAAGRRAPVLLGTGHPHRLLGFYVALAEALSAAGCTVLTPAQGRSVDITTRFGLRTYTIDYVRGVALVREHGAGRAGGEPGAHTHSPLPVRTALAAAAEGGGPLPELVIGDHGWVCGAGQLGFEAIGPADTDDPALFVGEAEGSVSVAVPLDDAVRSEYYRPLTRYVLNRACLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX10</accession>
    <name>Q9WX10_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5667 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3324</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36272">
        <property type="entry name" value="T36272"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627534.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028911.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3324"/>
    <dbReference type="GeneID" id="1098758"/>
    <dbReference type="KEGG" id="sco:SCO3324"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3384"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057124_0_0_11"/>
    <dbReference type="OMA" id="HDASEGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5667" evidence="2">
        <location>
            <begin position="153"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="419" mass="42839" checksum="2E7840515552EA81" modified="1999-11-01" version="1">MPPVIANVSAHRRANAFAQALEEQSDPGAAAEQSGGPATAGATAEPTEQGRLVTLAHGLETLPRPELDPEVKVVQRAQLVAAFEAMLQEGTASGGATDTSVPEQRRARGTHRAAPLSRFRPRSRLANCLTAGGLSVSVAAGAFGGVAAASSDALPGDSLYGLKRGIEDFRLGLADGNDERGRAYLDLASTRLSEARRLMERGRSGPLDHESLGEVRRALSGMRHDASEGHRLLSAAYAHDPGSLAPMQALSAFSQSHRETWGALRERLPVQLGDVSEQVSSVFDAIDDDVAPLQSMLPQPPAQDEGGGDAGLPGGSGSTTTGTPGSGHSSAPRTGDEGTSERGRSQSDRPSESADSGDESDGLLGGGTGGLLDPPKDDSGTASPSTGGGNTPPTQPDVTLPPLLPGLLPGLGIEAEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7V5</accession>
    <name>Q9X7V5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6760</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35400">
        <property type="entry name" value="T35400"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630832.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031162.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6760"/>
    <dbReference type="GeneID" id="1102199"/>
    <dbReference type="KEGG" id="sco:SCO6760"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6869"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_1_1_11"/>
    <dbReference type="InParanoid" id="Q9X7V5"/>
    <dbReference type="OMA" id="VKAPRIM"/>
    <dbReference type="PhylomeDB" id="Q9X7V5"/>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="312" mass="33961" checksum="6018BF4F037BEA71" modified="1999-11-01" version="1">MESSANMPAPVLAAYSYCEAVTGQQARNFAHGIRLLPTPKRRAMSALYAFSRRVDDIGDGVLADDVKVTRLDETRAVLARIQDGAVEEDDTDPVAVALADAARRFPIPLGGLDELIDGVQMDLRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTEPGARGAERAPEYADTLGLALQLTNILRDVREDAEGGRTYLPADDLAKFGCAAGFNGPTPPEGSDFAGLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVSLPGREKAYVAVRGLSGLDARHVTRRTVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Y1</accession>
    <name>Q9X7Y1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6786</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35426">
        <property type="entry name" value="T35426"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630858.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031181.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6786"/>
    <dbReference type="GeneID" id="1102225"/>
    <dbReference type="KEGG" id="sco:SCO6786"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6894"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_0_11"/>
    <dbReference type="InParanoid" id="Q9X7Y1"/>
    <dbReference type="OMA" id="KGKNFYH"/>
    <dbReference type="PhylomeDB" id="Q9X7Y1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB39719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="36489" checksum="5620DB36A69CFCDA" modified="1999-11-01" version="1">MELSSPLTYTGDPRTAADRAAALESAGLDAVWVAEAYGFDSPTIMGYLAARTERMRIGSAVLNVYSRSPALIAQTAAGLDALTGGRALLGIGASGPQVVEGWHGRRYDRPLGRTREVIELSRRIWRREVIEHRGITDLPLPPEKGGTLGKPLKLLTHPVRDTIPVYVAALGPANVRMTAELADGWLPFLYAPEHAAQVWGPSLAEGAAKRDPALGPLAVVAGGLLAVDDDAEAVHDLMRPTVALYVGGMGAPGRNFYHDLICSYGYEAAAAAIQEHYLAGRRKEAETAVPAELLARICLAGPEGHVRERVEAFRESGVTMLNVTPVGADPARLIERVRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Y3</accession>
    <name>Q9X7Y3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable acetyl coA acetyltransferase (Thiolase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6788</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35428">
        <property type="entry name" value="T35428"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630860.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031183.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6788"/>
    <dbReference type="GeneID" id="1102227"/>
    <dbReference type="KEGG" id="sco:SCO6788"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6896"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_11"/>
    <dbReference type="InParanoid" id="Q9X7Y3"/>
    <dbReference type="PhylomeDB" id="Q9X7Y3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB39721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="42122" checksum="FE9CC22433FCE00D" modified="1999-11-01" version="1">MSTEAYVYDAIRTPRGRGKANGALHGTKPVDLVVGLIQEIRARFPGLDPAAVDDIVLGVVGPVGDQGSDIARIAAIAAGLPDTVAGVQENRFCASGLEAVNMAAMKVRSGWEDLVLAGGVESMSRVPMGSDGGAWALDPRTNHDTGFVPQGIGADLIATIEGFSRRDVDEYAALSQERAAVASKDGRFHRSVVPVVDRSGLVVLDRDEHMRPGTTAESLAGLKPSFADIGELGGFDAVALQKYHWVERIDHVHHAGNSSGIVDGASLVAVGSKEVGDRYGLRPRARIVSAAVSGSEPTIMLTGPAPATRKALARAGLSIEDIDLVEINEAFAAVVLRFVKDMGLSLDKVNVNGGAIALGHPLGATGAMILGTLVDELERQDKRYGLATLCVGGGMGIATIVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8J4</accession>
    <name>Q9X8J4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3415</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36341">
        <property type="entry name" value="T36341"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627621.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028960.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3415"/>
    <dbReference type="ESTHER" id="strco-ester">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="1098852"/>
    <dbReference type="KEGG" id="sco:SCO3415"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3478"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_11"/>
    <dbReference type="InParanoid" id="Q9X8J4"/>
    <dbReference type="OMA" id="SEGMWHG"/>
    <dbReference type="PhylomeDB" id="Q9X8J4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB42768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="27208" checksum="3B2CC7B36BE7F9BE" modified="1999-11-01" version="1">MVSRRTVLGGRPALELAPDTASGPGRLLYLHGGGYLAGSPDTHAGLAGELARRAGLRAVSVDYRLAPEHPFPAAVDDGLAAYRELLSTGTDPQDLVLAGDSAGGGLGIATLLAAREAGLPQPAAVALFSPWVDLTLTGGSIRSKEGADPIFTEADVRAYADLYVGAGDRAAPLASPVFADLAGLPPLLVQAGANEVLLDDAVRLAGRAGADDVEVTLEVGPGLPHVYQLHYGRLEEADAALDRAARFLTAHLGAGHPDAGRLAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Q4</accession>
    <name>Q9X8Q4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3637</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36527">
        <property type="entry name" value="T36527"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627831.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029133.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1099073"/>
    <dbReference type="KEGG" id="sco:SCO3637"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3697"/>
    <dbReference type="eggNOG" id="ENOG503292E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626135_0_0_11"/>
    <dbReference type="OMA" id="CARWNND"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="145" mass="16186" checksum="ABCDF89E6A4F255D" modified="1999-11-01" version="1">MGCAPHPRGGCGVPEGGGKYFAALMIAPVPLVVPFKAGFHRRDWRPALGYSAGAVAGAVVALAMGTSLGHWIVALALVSSAALVPWCARWNNDAVREARQRERAQRQREERLARARARRSGRRRERRRRRRELRQQQQQQPDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8T7</accession>
    <name>Q9X8T7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO3901</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36588"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628087.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975030.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3901"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="GeneID" id="1099337"/>
    <dbReference type="KEGG" id="sco:SCO3901"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3975"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_6_0_11"/>
    <dbReference type="InParanoid" id="Q9X8T7"/>
    <dbReference type="OMA" id="TYYDPAG"/>
    <dbReference type="PhylomeDB" id="Q9X8T7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="71"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="452"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="795" mass="85392" checksum="8522D1B441181D4B" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Y7</accession>
    <name>Q9X8Y7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO3705</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB44408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T36640"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="72"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB44408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="29610" checksum="F4BCC299C38631E8" modified="1999-11-01" version="1">MTTPHRTGASAGPRAGGPRRRRQVQGGAPLPLLVPALIGLAFLVLPLVALLIRAPWASMPELLTSTEVWQALRLSLICATAATVVSMVIGVPLAWLLARVEFPGRGLVRALVTLPLVLPPVVGGVALLMALGRNGVVGQWLDSWFGITLPFTTTGVILAEAFVAMPFLVISVEGTLRAADPRYEEAATTLGASRFTAFRRVTLPLIAPGIAAGAVLAWARALGEFGATITFAGNFPGRTQTMPLAVYLALQSDPEAAVALSLVLLAVSVAVLAGLRDRWMTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAA7</accession>
    <name>Q9XAA7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0818</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36431">
        <property type="entry name" value="T36431"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027373.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0818"/>
    <dbReference type="GeneID" id="1096241"/>
    <dbReference type="KEGG" id="sco:SCO0818"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.810"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9XAA7"/>
    <dbReference type="OMA" id="CHNLETA"/>
    <dbReference type="PhylomeDB" id="Q9XAA7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB48895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="27975" checksum="96DCC261E9FF32A2" modified="1999-11-01" version="1">MMRMFRSGARGNHDPGPASEALRLVKVTRTYGSADNAVTALDGVTLSLGRGTFTAVMGPSGSGKSTLLQCAAGLDRPDSGIVCVDGKELTGGGEAELTKFRRGRVGFVFQQYNLLETLTVAQNTVLPLKLAGRRVDRKRAREVLTSVGLGDRLGHRPDQLSGGQRQRVAIARALVTEPRVIFADEPTGALDTRSARQVLLLLQEAARVHGRTVVMVTHDPVAASYADSVVFLADGRLAGRMDAPTPDAVAERLAHLGDDVPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAG8</accession>
    <name>Q9XAG8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5327</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35602">
        <property type="entry name" value="T35602"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629469.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5327"/>
    <dbReference type="GeneID" id="1100767"/>
    <dbReference type="KEGG" id="sco:SCO5327"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5413"/>
    <dbReference type="eggNOG" id="ENOG5030NAT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074104_3_0_11"/>
    <dbReference type="InParanoid" id="Q9XAG8"/>
    <dbReference type="OMA" id="CWRYVNE"/>
    <dbReference type="PhylomeDB" id="Q9XAG8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_4" evidence="4">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="96"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="27408" checksum="4A653756F9954470" modified="1999-11-01" version="1">MHPAALDLPHALVEWATMLIVTREGDRRCKLRPSQRAMVALVYLREHTTLAKIAAGFGISESTAHAYTRAVVDLLAACAPGLLKTLRDHEPDFVLLDGTLAECDRVGDGRADYSHKHRRHGVNVQVVTDPGGRLLWLSPALPGRTHDLTAARTHRIIRICERQGVPIVADLAYQGAGPWLTTGIKRKPLQELTPTDKTRNRALAAARAPVERGVARLKSWRIFRRSRCSPNRMTSIAKAVLTLELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z536</accession>
    <name>Q9Z536_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6136</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35919">
        <property type="entry name" value="T35919"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630242.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030678.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6136"/>
    <dbReference type="GeneID" id="1101577"/>
    <dbReference type="KEGG" id="sco:SCO6136"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6240"/>
    <dbReference type="eggNOG" id="ENOG5033KDT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852383_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z536"/>
    <dbReference type="OMA" id="YSSHPMD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="251"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="34952" checksum="106760BCE0D38A7B" modified="1999-05-01" version="1">MCQDCREQAFGGGDGFGGGHGMGRGGRTGHGVAPGVLVAAAVVGTLAVAALALRPAQGLLHSGRGPLGHWGFVAIGASVAWTFGTWTVVQRLRPRFGADRLSLPPGEERLREAAAPLLLAATGVIGVLALVLHRFSTGGNTTGPPPPLAREPAPTPTFLTPPPQQRHGSTDHSSLPLYLVLALLAAVAVVVVVVAVVRRLRRFGMRVPQRPGPPGTVAQDDDARLLLSAVDSGRRALAGTDDDARAAVIACYAAMEDALAASGVPRHASDSPADLLTRAAGTGFAPGPAAPRLTALFREARYSSHPMDGSHRKAAADALEEIASLLRDRDADAVREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBG7</accession>
    <name>Q9ZBG7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35933">
        <property type="entry name" value="T35933"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630531.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030925.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6446"/>
    <dbReference type="GeneID" id="1101885"/>
    <dbReference type="KEGG" id="sco:SCO6446"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6546"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043786_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBG7"/>
    <dbReference type="OMA" id="MVMNTAP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="183"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="34225" checksum="66B7A6D62FBD3273" modified="1999-05-01" version="1">MPRRPFAWSTVGRSSRRRPTGVTLSLHVTALTDPARTPSAQRLAWLACGDGGGPLGYAFLRVFTREGQDHLAELTLNVHAAERRRGVGSRLLDSAVAAAREAGRRSVVAQADADTPGDHFLAASGFRKVLALTYARLDLGGTGGGRAGETDAIVERPHPGYRLVSWRGTVPDDLAGTFADSRRAMDDMPMDDTDYGVVVWDVERVLAAARAVADRGEQLTTVAVVDESDGSVAGFSEFVVPGDGKGDGLHYGTGVLPEHRGHGLGRWMKAESIRLARAQHPDLAGLVTDTADSNTHMRRINDALGYAPTHRALEYQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBH1</accession>
    <name>Q9ZBH1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35929">
        <property type="entry name" value="T35929"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630527.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030922.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6442"/>
    <dbReference type="GeneID" id="1101881"/>
    <dbReference type="KEGG" id="sco:SCO6442"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6542"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_14_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBH1"/>
    <dbReference type="OMA" id="IAGCGMC"/>
    <dbReference type="PhylomeDB" id="Q9ZBH1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="367" mass="37854" checksum="B5C6F9D12B3E8EE4" modified="1999-05-01" version="1">MKFGAAVLRAYENPFTVEEVVLAEGPAEGEILVRIAGCGMCRTDLAVRRSGGRSPLPAVLGHEGSGVVVETGGTGTGLSAGDHVVLSFDSCGHCRNCMGAAPAHCDSFAALNLFGGRREHAARFTDTTGTALAPRWFGQSSFAEYALVPARNAVRVDPALPLELLGPLGCGFLTGAGAVLNSFGVGPGDTLAVFGAGAVGLAAVMAAHAAGAATVAVDRHPGRLALAERLHAVAVPATPTGLSDRILRLTGGGTTYALDTTGSAGLINEALRSLRPTGRLGLVARLHGTLPIEAGTLDRGRAIFHICEGDAVPGLLIPRLTALWQAGRFPFDQLIRTYPLADINEAEHDCETGRVVKPVLIPDGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O50485</accession>
    <name>O50485_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5767</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35137">
        <property type="entry name" value="T35137"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629892.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030441.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5767"/>
    <dbReference type="GeneID" id="1101209"/>
    <dbReference type="KEGG" id="sco:SCO5767"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5856"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_6_2_11"/>
    <dbReference type="InParanoid" id="O50485"/>
    <dbReference type="OMA" id="GAYVKRY"/>
    <dbReference type="PhylomeDB" id="O50485"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA15873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="402" mass="43915" checksum="A04B8597B5509B11" modified="1998-06-01" version="1">MPRWLPRAMVLALALIAAFQLGSWAFHQLTGLLINVLIAFFLALAIEPAVSWMAGRGMRRGFATFLVFLAVLIAAAGFVTLLGSMLAGQIVKMVEEFPDYLDSVINWVNGHFHTELRRVDIQEGLLRSDWLRNYVQNSATGVLDVSAQVLGGLFQLLTVLLFSFYFAADGPRLRRGLCSVLPPARQAEVLRAWEIAVDKTGGYLYSRGLMALVSGVAHYILLEILEVPYAPALAVWVGLVSQFIPTIGTYLAGALPMLIAFTVNPWYALWVLVFVVIYQQFENYVLQPKLTSKTVDIHPAVAFGSVIAGTALLGAVGALIAIPAVATLQAFLGAYVKRYDVTDDPRVHGRRGRRSVSGTSTRLRKLWTRRPEPGLEGPERTEGPERTEGGEGTDGTRDGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O69948</accession>
    <name>O69948_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6573</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34930">
        <property type="entry name" value="T34930"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630653.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031013.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6573"/>
    <dbReference type="GeneID" id="1102012"/>
    <dbReference type="KEGG" id="sco:SCO6573"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6678"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_0_0_11"/>
    <dbReference type="InParanoid" id="O69948"/>
    <dbReference type="OMA" id="WDHIAFD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="PTHR11510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="3">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="417" mass="41770" checksum="D38B6872FFADF5E4" modified="1998-08-01" version="1">MSASPSASSRGSRTGVWLIGARGSVATTVVAGCAAVTAGLHPPTGMVTETPDFAGAGLPALPALVFGGHDTVDCPLPKRAEALAAGGVLPHGLPSAVHAELAAADREIRPGGPLPGDTRDEEELIAAFAADITDFARRSGVDRTVVVNVASTEPAPAGGALPASSLYAAAALRAGCPYVNFTPSTGLHHPALSAPAEASGLPYAGRDGKTGQTLLRSVLGPMFAQRALAVRAWSGTNLLGGGDGAALADPAAAAAKNAGKERVLADTLGAPVEGEVHIDDVPVLGDWKTAWDHIAFDGFLGARMFLQTTWQGCDSSLAAPLVLDLARLVARAHQRGLSGPLGELGFFFKDPVGDGPSALAEQYGELKRFAGRLREDADGAPVDGDGGEGGANGSAGQSGDAVAVRPGGRGVEGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O86512</accession>
    <name>O86512_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5530</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29060">
        <property type="entry name" value="T29060"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629664.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973466.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5530"/>
    <dbReference type="GeneID" id="1100970"/>
    <dbReference type="KEGG" id="sco:SCO5530"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5617"/>
    <dbReference type="eggNOG" id="ENOG5030TN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049175_0_0_11"/>
    <dbReference type="OMA" id="REVPVCA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174864" evidence="3">
        <location>
            <begin position="34"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="450" mass="46632" checksum="F50487431699F94D" modified="1998-11-01" version="1">MKGVRAQVLIRLLVAPVVAALAVLLAGAPGAQAETGVSEIGAALRESPVYVDPAASGLLSRSDADALADKIEDAGEPVFVAVLPAGYPTENLFQNLRTETGITGLYGVRLGDRFDARADSSVLSRQGVHNLVTAVQGAGDPKAQLNDFVDDALRSVRGSAPSSWDSGGGSAPTGALITAGAVVVLGGAGVYAVSRRSRHRREAEQRAALERLRVVVDEDITAFGEELDRLDFHPAEPGADDAMRADYERALDAYEQAKTYMADARKPEDVRAVTQAVEDGRFSLAQLAARREGRPLPERRPPCFFDPRHGPSVADATWTPPGGTTRRVPVCAADQARLSDGRDPMIREVDTEYGRRPYWDAGPAYGPWAGGYFGGGILPGLLVGTMLGGMMAGPAYGAGYGTGYGDFGGYEGGDVSGGDFDPGDFGGGFGGGDFGGGGGFGGGGDFGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O86570</accession>
    <name>O86570_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SseB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAA20178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34755">
        <property type="entry name" value="T34755"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629611.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030271.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5475"/>
    <dbReference type="GeneID" id="1100915"/>
    <dbReference type="KEGG" id="sco:SCO5475"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5559"/>
    <dbReference type="eggNOG" id="ENOG5033T6R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000833_0_0_11"/>
    <dbReference type="OMA" id="WLNPHAP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB_C" evidence="2">
        <location>
            <begin position="136"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="28384" checksum="E46A548B9609F2C6" modified="1998-11-01" version="1">MSASGTTTGQVEHMLRQVTPGRYDAYEALLRALATPTSGQVWMLLWHGQAGSPDAQYGNMEVEGYGYAPCVTSAQELSASGWNRSYEVVDGLEAARALYPDHYGLWLNPHAPGGGVGIPWLDLRRIASGLDRQPAGPLRLSEPAIEIPQFYALLAQNAHRTPAVRALRRAWVQPALGAPYLAIGLDVYDTSPPAVDAVRAMMQQSVGAVPDGLPVSTVAMTDAHDPVALWLRANARPFYDREAHAPAPAQAPAGGYGYPPAGSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O86619</accession>
    <name>O86619_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6350</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29438">
        <property type="entry name" value="T29438"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630442.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030848.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6350"/>
    <dbReference type="GeneID" id="1101791"/>
    <dbReference type="KEGG" id="sco:SCO6350"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6462"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105089_0_0_11"/>
    <dbReference type="OMA" id="HRMLIYY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="194" mass="22081" checksum="A2224BCD0F849DE7" modified="1998-11-01" version="1">MGRHKQPEIRDRILDACVDHALAHGLPGRLEPFAAASGTSARMLIYHFGTRDALLRETLRRARRRQRDFFGELVAPRPDEPYPSTLRRAWRVMTGPAGRPYLTMFGRLREDAEQRLWPDFRRESTTDWLRPFEEGMRSIGRPELATLVLAVVRGLIMDIETTGDVARADRAFEDFLAALVLVTGTQARDAHGES</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O86678</accession>
    <name>O86678_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6631</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35040">
        <property type="entry name" value="T35040"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630707.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031057.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6631"/>
    <dbReference type="GeneID" id="1102070"/>
    <dbReference type="KEGG" id="sco:SCO6631"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6738"/>
    <dbReference type="eggNOG" id="ENOG502ZBZ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071994_0_1_11"/>
    <dbReference type="OMA" id="AYLYSWP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="30980" checksum="84A37FEF5492115C" modified="1998-11-01" version="1">MKQGKEVENPESRFFAVLLAAAKLPGVRIHREAYLRSALARHCSEDEIRRAVEKTPAAAGITVELLDKVAKDSIRYETAKVSALSAAAGIPGILALPATVPADVAQYVGHMLRIAQKLAYLYSWPDLFSDEGDDVDDATMGVLTLFFGVMFGTQSANVAVGKVAGMMSKQVAKKLPQKALTKGVIYPLVKKSAAYLGVQMTKQSFAKGVSKAIPVVGAVVSGGLTLATYLPMAKRLKKHLAGLPLADPSYEASEGDVVDGEVVEEHETLAPADAEPHDADTTTPKLEEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O86707</accession>
    <name>O86707_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6525</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35217">
        <property type="entry name" value="T35217"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030987.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6525"/>
    <dbReference type="GeneID" id="1101964"/>
    <dbReference type="KEGG" id="sco:SCO6525"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6628"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020884_1_2_11"/>
    <dbReference type="InParanoid" id="O86707"/>
    <dbReference type="OMA" id="IGPKTVY"/>
    <dbReference type="PhylomeDB" id="O86707"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="27815" checksum="3E62FB720E34236D" modified="1998-11-01" version="1">MELTWWGHATCTVEDSGIRVLTDPLFVRRLAHLRRRRGAVPPPEAWRADVALVSHLHADHLHVPSLARLAPGTRLLVPRGARRAVPGLRRLGHLELTEVVPGDETTVGDLRIRAVPARHDGRRLPVGRHRAPALGYVVEGEARTYFAGDTGLFDGMEQEVGPVDAALLPVGGWGPYLGAEHLDAGRAAEALARLAPRTAVPVHYGTYWPIGMDAVRPHEFHTPGEEFVRLSALRAPGVAVHRLGHGESVRVEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O88019</accession>
    <name>O88019_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO6663</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35162">
        <property type="entry name" value="T35162"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630738.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031086.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6663"/>
    <dbReference type="GeneID" id="1102102"/>
    <dbReference type="KEGG" id="sco:SCO6663"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6769"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_11"/>
    <dbReference type="InParanoid" id="O88019"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="PhylomeDB" id="O88019"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="377"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAA19942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="698" mass="74587" checksum="3E7DCB4FA782C366" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>P0A2Z6</accession>
    <accession>P50011</accession>
    <name>ATPE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpC</name>
        <name type="ordered locus">SCO5374</name>
        <name type="ORF">2SC6G5.18</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text>F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973623.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A2Z6"/>
    <dbReference type="SMR" id="P0A2Z6"/>
    <dbReference type="STRING" id="100226.SCO5374"/>
    <dbReference type="GeneID" id="1100814"/>
    <dbReference type="KEGG" id="sco:SCO5374"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5454"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_1_3_11"/>
    <dbReference type="InParanoid" id="P0A2Z6"/>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="PhylomeDB" id="P0A2Z6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000188214" description="ATP synthase epsilon chain">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="124" mass="13018" checksum="CC69D8FB510C81B7" modified="2007-01-23" version="2">MAAELHVALVAADREVWSGEATLVVARTTSGDIGVMPGHQPLLGVLESGPVTIRTSDGGTVVAAVHGGFISFADNKLSLLAEVAELSDEIDVHRAERKLEQAKTEGDAHAERRADVRLRAAAGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-04-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>P14705</accession>
    <name>YM1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Mini-circle uncharacterized 12.9 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1605</name>
        <name type="ORF">SCI35.27</name>
    </gene>
    <gene>
        <name type="ordered locus">SCO6402</name>
        <name type="ORF">SC3C8.20</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Mol. Microbiol." volume="3" first="1307" last="1318">
            <title>Structural and functional analysis of the mini-circle, a transposable element of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Henderson D.J."/>
                <person name="Lydiate D.J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="2575701"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1989.tb00112.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="X15942">
        <property type="protein sequence ID" value="CAA34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S06728">
        <property type="entry name" value="S06728"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625881.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027878.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P14705"/>
    <dbReference type="GeneID" id="1097036"/>
    <dbReference type="GeneID" id="1101841"/>
    <dbReference type="KEGG" id="sco:SCO1605"/>
    <dbReference type="KEGG" id="sco:SCO6402"/>
    <dbReference type="HOGENOM" id="CLU_2083469_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0814">Transposable element</keyword>
    <feature type="chain" id="PRO_0000075522" description="Mini-circle uncharacterized 12.9 kDa protein">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <sequence length="117" mass="12986" checksum="3716D21664634FA8" modified="1990-04-01" version="1">MTVVTCVFLDHVHHDPAQGDSLIADVTSFLFGQVAGVVQSCVSDQLTAAGDLGLPRGHRLVEPSSRLQGKAIMVALPEDRWHVLTCEHTLEPVAFHLSHVLHESQQRHRRGRRRSKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P16922</accession>
    <name>REDD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator RedD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">redD</name>
        <name type="ordered locus">SCO5877</name>
        <name type="ORF">SC2E9.18</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Bacteriol." volume="172" first="326" last="333">
            <title>Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Narva K.E."/>
                <person name="Feitelson J.S."/>
            </authorList>
            <dbReference type="PubMed" id="2294088"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>The RedD protein is probably one of several delicately balanced regulatory factors that contribute to the control of the biosynthesis of the antibiotic undecylprodigiosin (Red) in S.coelicolor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="M29790">
        <property type="protein sequence ID" value="AAA88556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34829">
        <property type="entry name" value="T34829"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629999.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030508.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P16922"/>
    <dbReference type="SMR" id="P16922"/>
    <dbReference type="STRING" id="100226.SCO5877"/>
    <dbReference type="PRIDE" id="P16922"/>
    <dbReference type="GeneID" id="1101319"/>
    <dbReference type="KEGG" id="sco:SCO5877"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5976"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004665_0_1_11"/>
    <dbReference type="InParanoid" id="P16922"/>
    <dbReference type="OMA" id="SAWMIRT"/>
    <dbReference type="PhylomeDB" id="P16922"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <feature type="chain" id="PRO_0000110007" description="Transcriptional regulator RedD">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="350" mass="37796" checksum="573C96C2203EFBBB" modified="1990-08-01" version="1">MTGGGVLATMDPVRKLVRSQPKIGRHPVAAGQDGRDRHPIRSWECGERARTARTGRTVGRAADPSDHGPSLYNFGGCVEINILGPVSIDTSHSGGGIRAGKVRTLVATLAIDAGRAVSLADLVDELWGATPPDNVLNALQAHAARARKVLNERACPERAGGILRSVLGGYLLEIDPQCVDGNRFLRLVSQGAALLPADPTRAVELLETGLRLWRGPALIDAGEGRRCRGAAALFEERRLTALEDLISAMFLRGGEAQAIAMLQQLVAQYPLRERFCELLMVGLYRVGRQGDALESYRLARKRLDDELGVQPGALLRRRHAEILAQDPVLKVPSALWREPYAPADTSLLSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>P46105</accession>
    <name>ACT22_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable actinorhodin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">actII-2</name>
        <name type="ordered locus">SCO5083</name>
        <name type="ORF">SCBAC28G1.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Cell" volume="66" first="769" last="780">
            <title>The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces.</title>
            <authorList>
                <person name="Fernandez-Moreno M.A."/>
                <person name="Caballero J.L."/>
                <person name="Hopwood D.A."/>
                <person name="Malpartida F."/>
            </authorList>
            <dbReference type="PubMed" id="1878971"/>
            <dbReference type="DOI" id="10.1016/0092-8674(91)90120-N"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Promotes the efflux of actinorhodin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. EmrB family.</text>
    </comment>
    <dbReference type="EMBL" id="M64683">
        <property type="protein sequence ID" value="AAA26690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B40046">
        <property type="entry name" value="B40046"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629233.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030046.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P46105"/>
    <dbReference type="SMR" id="P46105"/>
    <dbReference type="STRING" id="100226.SCO5083"/>
    <dbReference type="TCDB" id="2.A.1.3.25">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="GeneID" id="1100524"/>
    <dbReference type="KEGG" id="sco:SCO5083"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5163"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="P46105"/>
    <dbReference type="OMA" id="GMFGPVM"/>
    <dbReference type="PhylomeDB" id="P46105"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000173313" description="Probable actinorhodin transporter">
        <location>
            <begin position="1"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="578" mass="59772" checksum="E6C1DC75E6038B92" modified="1995-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-02-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q04310</accession>
    <accession>Q9F2T3</accession>
    <name>Y4629_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO4629</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4629</name>
        <name type="ORF">SCD39.29</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Mol. Gen. Genet." volume="217" first="324" last="331">
            <title>Identification and characterization of a locus inhibiting extrachromosomal maintenance of the Streptomyces plasmid SLP1.</title>
            <authorList>
                <person name="Grant S.R."/>
                <person name="Lee S.C."/>
                <person name="Kendall K."/>
                <person name="Cohen S.N."/>
            </authorList>
            <dbReference type="PubMed" id="2770697"/>
            <dbReference type="DOI" id="10.1007/BF02464900"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>The imp locus inhibits the extrachromosomal maintenance of the streptomyces plasmid SLP1. May function as a transcriptional activator.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">To E.coli YdcF.</text>
    </comment>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAA33876" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="X15866">
        <property type="protein sequence ID" value="CAA33876.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ0324">
        <property type="entry name" value="JQ0324"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628791.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029778.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q04310"/>
    <dbReference type="SMR" id="Q04310"/>
    <dbReference type="STRING" id="100226.SCO4629"/>
    <dbReference type="GeneID" id="1100069"/>
    <dbReference type="KEGG" id="sco:SCO4629"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4702"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064561_0_0_11"/>
    <dbReference type="InParanoid" id="Q04310"/>
    <dbReference type="OMA" id="KPFMERR"/>
    <dbReference type="PhylomeDB" id="Q04310"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205351" description="Uncharacterized protein SCO4629">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="221" mass="24872" checksum="86606D686A3FCAD0" modified="2002-05-02" version="2">MISAHVWADAQRLWDFQQMGHEPHPCSVAIGLGSHDLGVAETTAELYHRGMAPVIVFTGATSRTTHERMPRGEAEHYRERAVELGVPERAILVEPNARNTGENIRLSRALLEDLGMPVTSVLLVSKPYEERRAYATARKLWPNVEWVCVSTSMTLPDYVKSIGDARLVIDMLVGAQQRLMVYPRQGFMIKQEIPEPIMTAYEHLRGHGFTSRLVPETAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKR9</accession>
    <name>Q7AKR9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0701</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S23604">
        <property type="entry name" value="S23604"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625007.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978161.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0701"/>
    <dbReference type="GeneID" id="1096124"/>
    <dbReference type="KEGG" id="sco:SCO0701"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.688"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127143_0_0_11"/>
    <dbReference type="OMA" id="PFLWELA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="16482" checksum="AE22FBBF9C86E1A4" modified="2012-05-16" version="1">MPWSDIQDSTGSAAAIPRLLRKVARGDAETARAALGDLRRRICQYGFVVEQATAATVPFLWELAQRPQVSCRAQIIQLLKNIADARQWETTATAYPKLLNHRENPVAWERAARQAVRARRDGLERLLADDDTEIMRATSELARTLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJR3</accession>
    <name>Q8CJR3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative muramoyl-pentapeptide carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5467</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAD55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733665.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030267.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5467"/>
    <dbReference type="MEROPS" id="M15.001"/>
    <dbReference type="GeneID" id="1100907"/>
    <dbReference type="KEGG" id="sco:SCO5467"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5551"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119635_0_0_11"/>
    <dbReference type="OMA" id="YWSAPTC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176130" evidence="1">
        <location>
            <begin position="33"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="3">
        <location>
            <begin position="117"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="25621" checksum="EF03B299839D09F3" modified="2003-03-01" version="1">MFRRVSRLLLSFVMLMAGAVVGVGATAGAAHADSCYTWNRTLSQGASGSDVTQLQIRVAGWVTSGERLSYDGQYGARTAAAVKKFQAAYGLGADGVAGPATFSKIYALQDADCTPVHFTYAELNKCNSDWSGGAVSAATAKSNALKTMWKLEAMRHALGDVPITISSGFRSRACNSAVGGSSTSRHLYGDAADLTGSPSFCRLAQQARTHGFSEILGPGYPGHNDHTHVAFDPSPYWSAPNCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJS2</accession>
    <name>Q8CJS2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptide transport system ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5116</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD55223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733655.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973861.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5116"/>
    <dbReference type="TCDB" id="3.A.1.5.36">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100557"/>
    <dbReference type="KEGG" id="sco:SCO5116"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5199"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="Q8CJS2"/>
    <dbReference type="OMA" id="CHFPEDP"/>
    <dbReference type="PhylomeDB" id="Q8CJS2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="381" mass="41788" checksum="68EFE12806287FD0" modified="2003-03-01" version="1">MSDNSKTTTAVADDFPQQRDGDTAPLLKVSGLSKHFPIKGGFPIKRTVGHVKAVDGVDFEVFPGESLGLVGESGCGKSTTGRLLTRLYEPTQGSIEYRGKDITRANRRELAPVRSEIQMIFQDPYASLNPRQTVGTIISGPMEINGINPPGGREKRVRELLEIVGLNPEHYNRFPHEFSGGQRQRIGVARAVALQPKLIVADEPVSALDVSIQAQVVNLLQEVQREMGIAFVFIAHDLAIVRHFSQRVAVMYLGKIVEIADRDSLYNRPRHPYTHALLSAVPETDLDAEKRERIRLEGDVPSPISPPSGCRFRTRCWKAQDKCATEEPPLVQLSGNREGHLTACHFPEEGSTEARAEDIVMDPGLKAMEDGADGGATLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J53</accession>
    <name>Q93J53_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3049</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627270.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975762.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3049"/>
    <dbReference type="GeneID" id="1098482"/>
    <dbReference type="KEGG" id="sco:SCO3049"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3109"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_0_11"/>
    <dbReference type="InParanoid" id="Q93J53"/>
    <dbReference type="OMA" id="MDEMAFL"/>
    <dbReference type="PhylomeDB" id="Q93J53"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036042">
        <property type="term" value="F:long-chain fatty acyl-CoA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC44514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="21560" checksum="94EFBE1BB5D96D3D" modified="2001-12-01" version="1">MWPRHKVEAMTDQAEQASAAQSTAPEIPGKPTSASRTTLSHIMTHSDTNLLGTVHGGVIMKLVDDAAGAVAGRHSGGPAVTASMDEMAFLEPVRVGDLVHVKAQVNWTGRSSMEVGVRVLAERWNESTPATQVGSAYLVFAAVDADGKPRTVPPVLPETEKDKRRYQEAQIRRTHRLARRRAIMELRERRVAEGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JA0</accession>
    <name>Q93JA0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7497</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631543.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031705.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7497"/>
    <dbReference type="GeneID" id="1102935"/>
    <dbReference type="KEGG" id="sco:SCO7497"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7610"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_87_4_11"/>
    <dbReference type="InParanoid" id="Q93JA0"/>
    <dbReference type="OMA" id="HARGQLF"/>
    <dbReference type="PhylomeDB" id="Q93JA0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="28044" checksum="A3E20D78CD50C756" modified="2001-12-01" version="1">MKNVPLADVDHVDRAVLPIGTDYPPGHVLDWHEHRRAQFLYGATGVMVVDTGDGTWTVPPERAVLIPAATRHRVRMLGVSTRSLYIEPDAVPWWPGTCTVVDVPPLLRELLLTAVEFEADYSLSGRAGSVADLLLHEIAARAPLPFHVRIPAGADLAALCREYLAAPDTGVTNAVWAARTNMSERAFTRRFRAETGDSPAVWRGRARLLAAVPLLRSGSVSEVGGRLGYASPAAFTAAFTRTFGIPPSRFAQGHRGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JE8</accession>
    <name>Q93JE8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5979</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2009-02" db="PDB data bank">
            <title>Crystal Structure of Putative Enoyl-CoA Hydratase from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Kim Y."/>
                <person name="Xu X."/>
                <person name="Cui H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A.M."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630095.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973042.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="PDB" id="3G64">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B/C=1-275"/>
    </dbReference>
    <dbReference type="PDBsum" id="3G64"/>
    <dbReference type="SMR" id="Q93JE8"/>
    <dbReference type="STRING" id="100226.SCO5979"/>
    <dbReference type="DNASU" id="1101421"/>
    <dbReference type="GeneID" id="1101421"/>
    <dbReference type="KEGG" id="sco:SCO5979"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6078"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_11"/>
    <dbReference type="InParanoid" id="Q93JE8"/>
    <dbReference type="OMA" id="HCLGAGI"/>
    <dbReference type="PhylomeDB" id="Q93JE8"/>
    <dbReference type="EvolutionaryTrace" id="Q93JE8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3G64"/>
        </source>
    </evidence>
    <sequence length="275" mass="29291" checksum="CA7F4E42DE7F035B" modified="2001-12-01" version="1">MSPFTGSAAPTPEWRHLRVEITDGVATVTLARPDKLNALTFEAYADLRDLLAELSRRRAVRALVLAGEGRGFCSGGDVDEIIGATLSMDTARLLDFNRMTGQVVRAVRECPFPVIAALHGVAAGAGAVLALAADFRVADPSTRFAFLFTRVGLSGGDMGAAYLLPRVVGLGHATRLLMLGDTVRAPEAERIGLISELTEEGRADEAARTLARRLADGPALAHAQTKALLTAELDMPLAAAVELDASTQALLMTGEDYAEFHAAFTEKRPPKWQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JG5</accession>
    <name>Q93JG5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7707</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631745.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971432.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7707"/>
    <dbReference type="GeneID" id="1103145"/>
    <dbReference type="KEGG" id="sco:SCO7707"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7827"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142247_2_0_11"/>
    <dbReference type="OMA" id="HIEYVDD"/>
    <dbReference type="PhylomeDB" id="Q93JG5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038646">
        <property type="entry name" value="Atu4866-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020955">
        <property type="entry name" value="Uncharacterised_Atu4866"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11512">
        <property type="entry name" value="Atu4866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="10590" checksum="7DCDAEB8FDB353AB" modified="2001-12-01" version="1">MTANARDRSNRENADVVGTWVTADGHIRQELLPDGRYDEARGDRRSAYTGRYTVTGDHLDYVDDTGFTATGDLRDGVLHHEHLVLYREEKPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ9</accession>
    <name>Q93JJ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4995</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629147.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029991.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4995"/>
    <dbReference type="GeneID" id="1100436"/>
    <dbReference type="KEGG" id="sco:SCO4995"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5076"/>
    <dbReference type="eggNOG" id="ENOG5033RRU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053850_0_0_11"/>
    <dbReference type="OMA" id="QGYEYPD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC40608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="420" mass="44445" checksum="C0B0455AD552A435" modified="2001-12-01" version="1">MLENERQDPFEDRLGTALRDAGDGFEADRAALVTAGRARGRRALLRRRAAVVGGVAGVALAGVGGVLVLPADHPAGPDRSGTASAPSAGDATTAAASFTGDDLLHELKGLLPPGTYGEESARGSDHQLGPTAQLVYDDGAGAAAIGMGFARVEPGSAQVRELMACPDHNITPYDDCSSDRLPDGSLLKLYQGYEYPDLRVDTKRWTADLVTAEGQHVSVSEWNSPAEKGAPVSREEPPLSTERLRELVTAGVWREVVDAVPKSRKPPRSAAPRTERPEVSGKSVGDTLAALLPRKLDVVSRGGQESEYAYVVVDDGRGRSLVQINVQHGMADVAGQLYADGETLPDGTRVATRQGPGEKAGSGVVMWTVDTLRPGPAGFRVVISAFNTGDQNKDATRDAPALTMEQLRKIALSGEWDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK3</accession>
    <name>Q93JK3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4991</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629143.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029989.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4991"/>
    <dbReference type="GeneID" id="1100432"/>
    <dbReference type="KEGG" id="sco:SCO4991"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5072"/>
    <dbReference type="eggNOG" id="COG2610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027949_0_2_11"/>
    <dbReference type="InParanoid" id="Q93JK3"/>
    <dbReference type="OMA" id="MGGILGH"/>
    <dbReference type="PhylomeDB" id="Q93JK3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="46"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="191"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC40604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="492" mass="50616" checksum="A38A0CC71380D542" modified="2001-12-01" version="1">MSYSSLRLAAAEAPPHTGGLLTLIDGTAGLLTVAAIGIALLLFLIIKVRLQPFVALLAVSIAVGLLAGLSVTELFGTVQKSDAVSTIESGMGGILGHVAIIIGLGTMLGAILEVSGGAQVLASRLLGLFGEKRAPLAMGLTGLIFGIPVFFDVGIFVLAPIVYAAAKRSGKSILLYCLPLLAGLSMTHAFLPPHPGPVAAAGLLNVKLGWIILMGIVCGIPAVLAAWVFSAWIGRRIFVPVPQDMVEASEEAKQAVIEEQRKAGVAPNESPVALGTVLGIIGTPLVLILAATFSSIALDPSTLRSVIEFFGNPFVALTIALLLAYYLLGIRRGWSRKSLETVSTASLKPVGNILLVVGAGGVFGAVLKASGVAQALSDTFNDVGLPVIVLAYLISVVLRVAQGSATVAIVTTAGIVAPLLAEGDHSQAFVALVIMAISAGSIFASHVNDGGFWMVAKYFGISERDTLKTWTVLESVLSVAGFVVAAVVSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RS7</accession>
    <name>Q93RS7_STRCO</name>
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        <submittedName>
            <fullName evidence="2">SCO6317 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">SCO6317</name>
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    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="30" mass="3363" checksum="6BFF32A95384917A" modified="2001-12-01" version="1" fragment="single">VAYEAPFRCRTVASGSGPRSDRYHNLRAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD26</accession>
    <name>Q9AD26_STRCO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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    </organism>
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        <name>SCP1</name>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC36645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8887" checksum="656B95E0B453854A" modified="2001-06-01" version="1">MTPRHSRPEGAEKRLEEAVRAAKRQRDKAVRQAETTFWTEIAELKQSYRGAQTDIASVLGVTRDAILKSVNKYAGGQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJX2</accession>
    <name>Q9AJX2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">SCO1805</name>
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    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC28545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626074.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977017.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1805"/>
    <dbReference type="GeneID" id="1097239"/>
    <dbReference type="KEGG" id="sco:SCO1805"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1826"/>
    <dbReference type="eggNOG" id="COG3953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083020_1_0_11"/>
    <dbReference type="InParanoid" id="Q9AJX2"/>
    <dbReference type="OMA" id="GTSWDIY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176620" evidence="2">
        <location>
            <begin position="51"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC28545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="25524" checksum="61999D62CA23A7B0" modified="2001-06-01" version="1">MLKNILPRGRSRSLNRTQKAAIAGVGALGAAAVALTAVPASGQTTTTSEAAPTAKVAYSTKQIQDVHAGVTGQLAGASQKVAAIEAKKEAAAKKATAKKATAEKKAAAEKAAAKRAAKETTSRSAQRTEVKKAAPKSYPNNLDGWIREARSIMKKHGIPGTYEGIHRNIMRESSGNPKAINDWDINAINGIPSKGLLQVIPPTFAAYHVPGTSKNIYDPVANIVAACNYAADKYGTMDNVDSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK62</accession>
    <name>Q9AK62_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4055</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628237.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974908.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4055"/>
    <dbReference type="GeneID" id="1099491"/>
    <dbReference type="KEGG" id="sco:SCO4055"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4117"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_11"/>
    <dbReference type="InParanoid" id="Q9AK62"/>
    <dbReference type="OMA" id="WAKAQSF"/>
    <dbReference type="PhylomeDB" id="Q9AK62"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N_assoc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="185"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="377" mass="40031" checksum="6EE9079B5854A28D" modified="2001-06-01" version="1">MKAVVYKGPFSVAVEDVEKPDIRHPNDVIVRVTSTAICGSDLHMYEGRTAAEPGIVFGHENMGIVDQVGQGVTGLKKGDRVVMPFNVACGFCTNCAAGYTGYCTTVNPGFAGGAYGYVSMGPWQGGQAEYLRVPYADFNCLKLPEGDAHETDFILLADIFPTGYHGCELADVRPGESVAVYGAGPVGLMAAYSALLRGAKKVFVVDRVPERLQKAEEIGAVPVDFSAGDPVEQIKEQTEGAGTDKGVDAVGYQATAGGTGKEEPATVLNSLVNTVRPTGALGVPGLYVPADPGGPDEQAKQGMLLVAIGKLFEKGLRVGTGQCNVKRYNRQLRDMIIEGRAEPSFVVSHELPLDQAPSGYDKFDKRIEGYTKVVLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWD7</accession>
    <name>Q9EWD7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629024.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029917.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4870"/>
    <dbReference type="GeneID" id="1100311"/>
    <dbReference type="KEGG" id="sco:SCO4870"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4949"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_3_11"/>
    <dbReference type="InParanoid" id="Q9EWD7"/>
    <dbReference type="OMA" id="PQWRTQE"/>
    <dbReference type="PhylomeDB" id="Q9EWD7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="15"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="483" mass="50754" checksum="C93F00B2BDE97CFB" modified="2001-03-01" version="1">MNVTDTHVAGTDVPDTDVLIVGAGPTGLTLGVELARRGVHALVLEGAGELFPGSRGKGFQPRTMEVFDDLGVVDALHAVGGPYPIGMIWRNGERVGEHHMFDPAEPSEDSPYNRAWMVPQWRTQEILAARLAELGGRVAFRHEVVGVAQDAEGVTAHLSSGGTVRARYLVAADGGRSAARRALGIGMTGETVDPSPTLVADVRISGLDRDNWHVFPPGDGVDLLAVCPLAGTEDFQVMARFPEGADLDTSADGVRKVVAERSHIAAEDVTEVRWVSDFRPRAALADRFRDGRVFLAGDAAHVHSPAGGQGLNTSVQDAYNLGWKLGAVLKGDAPAALLDSYEEERRPIAAQMLDLSTAVHRGEVRRGGATRQLGIGYRDSSLTVETRGAVGEEAVRAGDRAPDGRVDGVRLFDAFRGPHWTLLALGVDAPGGGVGAAVPVVRGGAHGAYGAGLFLVRPDGYVGWAGDTPDGLGAYLGRFGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWH2</accession>
    <name>Q9EWH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4977</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2007-01" db="PDB data bank">
            <title>The crystal structure of a tetR-family transcriptional regulator from Streptomyces coelicolor A3.</title>
            <authorList>
                <person name="Tan K."/>
                <person name="Xu X."/>
                <person name="Zheng H."/>
                <person name="Savchenko A."/>
                <person name="Edwards A."/>
                <person name="Joachimiak A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 3-235</scope>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029983.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="PDB" id="2OF7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=2-235"/>
    </dbReference>
    <dbReference type="PDBsum" id="2OF7"/>
    <dbReference type="SMR" id="Q9EWH2"/>
    <dbReference type="STRING" id="100226.SCO4977"/>
    <dbReference type="GeneID" id="1100418"/>
    <dbReference type="KEGG" id="sco:SCO4977"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5058"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="InParanoid" id="Q9EWH2"/>
    <dbReference type="OMA" id="MYGIPEA"/>
    <dbReference type="PhylomeDB" id="Q9EWH2"/>
    <dbReference type="EvolutionaryTrace" id="Q9EWH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD30962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="2OF7"/>
        </source>
    </evidence>
    <sequence length="235" mass="26104" checksum="1C5B16F243362999" modified="2001-03-01" version="1">MTAARSAPSPAGAPRPGLRERKKTRTREAIRAATYGLIRQQGYEATTVEQIAERAEVSPSTVLRYFPTREDIVLTDEYDPVMAAELAARPAGEPWSDSLRHVLRKALGLGAGEEAELIRLRTRLLAEVPAVRARMLENMSDTGRMLARAIADRTGLDPDGLEVRIVSMSLVGGLMEVSRYWAEHDHEESLAELVDRALDALENGLPALRESDRESDREGDRGGHREDRREGPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWR4</accession>
    <name>Q9EWR4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0788</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625090.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978072.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0788"/>
    <dbReference type="GeneID" id="1096211"/>
    <dbReference type="KEGG" id="sco:SCO0788"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.780"/>
    <dbReference type="eggNOG" id="ENOG5031P3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171136_0_0_11"/>
    <dbReference type="OMA" id="RIMVLGV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8356" checksum="AC19538E7ABBB148" modified="2001-03-01" version="1">MTEIDSPHIGSPRILVLGVQAGPPPFRIVEIDGQVVGEAKAVTDVLEAAAAFGITVHDLDDPDVVRWVGGDKFTWKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWV9</accession>
    <name>Q9EWV9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4927</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629080.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029953.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9EWV9"/>
    <dbReference type="STRING" id="100226.SCO4927"/>
    <dbReference type="GeneID" id="1100368"/>
    <dbReference type="KEGG" id="sco:SCO4927"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5006"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_5_0_11"/>
    <dbReference type="InParanoid" id="Q9EWV9"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="PhylomeDB" id="Q9EWV9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="30545" checksum="7C98648485F87C6F" modified="2001-03-01" version="1">MTPRDSSDSPDSPRNRWSDLDRPPLSSTALRRGLVRDGGLWRQVDVVQRTGSTNSDLVARAAEGDLAEGVVLVAEEQSAARGRLDRQWTAPARSGLFFSVLLRPAEIPVARWGWLPLLTGVAVATGLSRVAGVDTALKWPNDLLVTVGDEERKAGGILAERAGDDGVVIGVGINVSLRADELPVPRAGSLALAGAVNTDRDPLMRGVLRSLEDWYGRWRGAGGDPAASGLQETYAAGCATLGRMVRAELPGDRSLVGEAVAVDGDGRLVLATGAGVQEPVGAGDIVHLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWZ4</accession>
    <name>Q9EWZ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1132</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625425.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027598.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1132"/>
    <dbReference type="GeneID" id="1096555"/>
    <dbReference type="KEGG" id="sco:SCO1132"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1129"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_2_11"/>
    <dbReference type="InParanoid" id="Q9EWZ4"/>
    <dbReference type="OMA" id="SMGTRSW"/>
    <dbReference type="PhylomeDB" id="Q9EWZ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="715" mass="75168" checksum="F55B88F9E7C89404" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX37</accession>
    <name>Q9EX37_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1002</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625298.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977879.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1002"/>
    <dbReference type="GeneID" id="1096425"/>
    <dbReference type="KEGG" id="sco:SCO1002"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.999"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160733_0_0_11"/>
    <dbReference type="OMA" id="GMNAFFV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="128" mass="13893" checksum="B24DCD4078E1D4C2" modified="2001-03-01" version="1">MSSSEAALALGRTFHQALVSADWSGIRALLHDDATWTLPGDNTISGTADGADAVVERAQRIASYGLDFKLLHLLVSRENLALSLHNTARREDVVLDEHLATVCRLRDGKIASIETYLSDVPGMNAFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX53</accession>
    <name>Q9EX53_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6274</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC22145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630373.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030786.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6274"/>
    <dbReference type="GeneID" id="1101715"/>
    <dbReference type="KEGG" id="sco:SCO6274"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6390"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_35_8_11"/>
    <dbReference type="InParanoid" id="Q9EX53"/>
    <dbReference type="OMA" id="ATHERHA"/>
    <dbReference type="PhylomeDB" id="Q9EX53"/>
    <dbReference type="BioCyc" id="MetaCyc:SCO6274-MON"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071770">
        <property type="term" value="P:DIM/DIP cell wall layer assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1698"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3417"/>
            <end position="3492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1397"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2220"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1733"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC22145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="3576" mass="377357" checksum="8A83C6F90AC9928B" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F1Y5</accession>
    <name>GPPMT_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Geranyl diphosphate 2-C-methyltransferase</fullName>
            <shortName>GPP methyltransferase</shortName>
            <ecNumber>2.1.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO7701</name>
        <name type="ORF">orf4</name>
        <name type="ORF">SCBAC12C8.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-11" db="EMBL/GenBank/DDBJ databases">
            <title>S.coelicolor orf3 orf1 p52 orf2 orf4 orf5.</title>
            <authorList>
                <person name="Watanabe M."/>
                <person name="Kawamoto S."/>
                <person name="Ochi K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / 1147</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="J. Am. Chem. Soc." volume="130" first="8908" last="8909">
            <title>Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Wang C.M."/>
                <person name="Cane D.E."/>
            </authorList>
            <dbReference type="PubMed" id="18563898"/>
            <dbReference type="DOI" id="10.1021/ja803639g"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>PATHWAY</scope>
        <scope>KINETIC PARAMETERS</scope>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2010" name="J. Am. Chem. Soc." volume="132" first="9509" last="9509">
            <authorList>
                <person name="Wang C.M."/>
                <person name="Cane D.E."/>
            </authorList>
            <dbReference type="DOI" id="10.1021/ja104306p"/>
        </citation>
        <scope>ERRATUM OF PUBMED:18563898</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the SAM-dependent methylation of geranyl diphosphate (GPP) to yield (E)-2-methylgeranyl diphosphate (2-MeGPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-geranyl diphosphate + S-adenosyl-L-methionine = (E)-2-methylgeranyl diphosphate + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:32519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61984"/>
            <dbReference type="EC" id="2.1.1.255"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="1">13.1 uM for geranyl diphosphate</KM>
            <KM evidence="1">4.3 uM for S-adenosyl-L-methionine</KM>
        </kinetics>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the geranyl diphosphate 2-C-methyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAB20434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CAC44557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L=1-292"/>
    </dbReference>
    <dbReference type="PDB" id="3VC2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L=1-292"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.7821"/>
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    <dbReference type="OMA" id="AHFECNI"/>
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    <dbReference type="BioCyc" id="MetaCyc:MON-17559"/>
    <dbReference type="BRENDA" id="2.1.1.255">
        <property type="organism ID" value="5998"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
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        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042214">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000403379" description="Geranyl diphosphate 2-C-methyltransferase">
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            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
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    <feature type="helix" evidence="4">
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    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="100"/>
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        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
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            <end position="128"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="130"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="strand" evidence="4">
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        </location>
    </feature>
    <feature type="strand" evidence="4">
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    <evidence type="ECO:0000269" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000305" key="2"/>
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        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3VC1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32824" checksum="73D2386F9D40A48D" modified="2001-03-01" version="1">MTTETTTATATAKIPAPATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGPVDRAALGDPEHSEYEKKVIAELHRLESAQAEFLMDHLGQAGPDDTLVDAGCGRGGSMVMAHRRFGSRVEGVTLSAAQADFGNRRARELRIDDHVRSRVCNMLDTPFDKGAVTASWNNESTMYVDLHDLFSEHSRFLKVGGRYVTITGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPHTIVDLTPDTLPYWELRATSSLVTGIEKAFIESYRDGSFQYVLIAADRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3J9</accession>
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    <organism evidence="2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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                <person name="Barrell B.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
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    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC05953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="28574" checksum="261B9EC3963D7C65" modified="2001-03-01" version="1">MSTEESVSAPTPGALLLCRAEPDSVAAVAPLLGERMPLVRAGAQWSALVPEGGPWRDGREPVDRVVAGWAAALAVGAPWPVLALWWDADRAGYVLASGFRRPVGYVWLADGTPAGEDEAMRTFAARLGLDPVLDVQSLDRLTRADPDAEREFGAGAGARARLRGLLAVLARGGISLPAGLDPGEGAARLGAAARALPGVRRTESAGLRPTVDESPLAAWMPWTGGPGARVLALTQVATGLPLTVWGLRRRSGGWAAAGALLVGHGALGAAYGLSRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3K8</accession>
    <name>Q9F3K8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
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    <gene>
        <name evidence="3" type="ordered locus">SCO5257</name>
    </gene>
    <organism evidence="4">
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        <lineage>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="Pfam" id="PF13649">
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    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="29542" checksum="DF61934EA8F04B07" modified="2001-03-01" version="1">MTNADTTTATTAGTTATTTATAGADWQAWQRSWDRQQEWYMPDREERFRIMLDMVEALVGPAPRVLDLACGTGTITARLLDRFPDATSTGVDLDPALLAIAEGTFAGDDRVSFVAADLKDPDWPAKLPYDAYDAVLTATALHWFHAEPLADLYGRVAELVRDGGVFMNADHMIDEATPRINAAERAQRHARMDAAKGQGALDWAEWWQLAAEDPVLAGPTARRFEIYGEHADGEMPSAAWHARVLREKGFGEARPVWCSPSDTLLLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3P5</accession>
    <name>Q9F3P5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7642</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031798.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7642"/>
    <dbReference type="GeneID" id="1103080"/>
    <dbReference type="KEGG" id="sco:SCO7642"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7762"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_4_11"/>
    <dbReference type="InParanoid" id="Q9F3P5"/>
    <dbReference type="OMA" id="REMPQGR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="121" mass="12844" checksum="B2EA9A7BB391342D" modified="2001-03-01" version="1">MSRATRITHVATVGIRVADQRKATEFYVGELGFEVRRDVPFGGGRWIEVAPPGATTTVALVPEGVPGGIRLATRDADADHADLRARGVDADAEVLRTGPGVPHMFAVRDPDGNDLIVVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBM9</accession>
    <name>Q9FBM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nucleotide-sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5050</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629202.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973927.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5050"/>
    <dbReference type="GeneID" id="1100491"/>
    <dbReference type="KEGG" id="sco:SCO5050"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5130"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_11"/>
    <dbReference type="InParanoid" id="Q9FBM9"/>
    <dbReference type="OMA" id="FENCYRM"/>
    <dbReference type="PhylomeDB" id="Q9FBM9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="5">
        <location>
            <begin position="330"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC05895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="443" mass="46365" checksum="FAF858ED4308BE08" modified="2001-03-01" version="1">MKFKSDSSHFDVSGPTVAVVGLGYVGLPTALALCDAGATVIGVDSSPERLRDIARGAVDLLPLHHAQLACASAGDRFRLTPDATAVRDADAVVICVPTPVDARRRPDLAALSAACASVVEHAVPGQLIVLTSTSYVGTTRDLLVEPLRARGLTVDEDVYVAFAPERIDPGNERHTPERTPRLVGGAGPRSSRAAADLLAPTASAVRTVPDPETAEMAKLWENTYRAVNIALANELADACHSLGLAPAPVIEAAATKPYGFMPFYPGPGVGGHCIPCDPHYLLWQLGKVRQQAPLVATALAANSRRPARITERALDLLADSAVPAHGARVLLIGVAYKEGVADVRESPALEILAGLAEAGAHVAYCDPLVPSLRVGADALHHLPDPHTRPWDLVVLNTVHPVHDLTWLCADDAPPVLDTRQRGPLTKAAARAATGVPPAAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBW7</accession>
    <name>Q9FBW7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7818</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631846.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971321.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1103256"/>
    <dbReference type="KEGG" id="sco:SCO7818"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7929"/>
    <dbReference type="eggNOG" id="COG3967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_11"/>
    <dbReference type="InParanoid" id="Q9FBW7"/>
    <dbReference type="OMA" id="WSMNLRT"/>
    <dbReference type="PhylomeDB" id="Q9FBW7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC03636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="27203" checksum="59753E16415A0DBF" modified="2001-03-01" version="1">MNISGNTIFIPGSTSGIGLALALALQARGNTVIVGGRRAELLEQIAARHPGIGTVQIDTTDAASIASAAKQVLAGYPDLNVLVTMAGVMHIEDWRRPASFLTTAESTITTNVLGPIRLIAAFVEHLQAQSDATIMTVSSGLAFTPLKVTPSYNASKAAIHLLSESVRLQFAGTSVKILELEPPSVRTALLPGQEDNEHAMPLDEFIAEVVSLIETQPDAREIQVERVKYLRYGEARGDYEQVVETLNHSDPHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC83</accession>
    <name>Q9FC83_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7103</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631164.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031433.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102541"/>
    <dbReference type="KEGG" id="sco:SCO7103"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7204"/>
    <dbReference type="eggNOG" id="ENOG5031Y5S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2541155_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="99" mass="10612" checksum="E8EE524406323843" modified="2001-03-01" version="1">MSTVHEPTARAEEGRGMSRSTDRQTDPAAATASLAAEAALLEGRLSLLREAIDSVDARIDAVSETLRRLQRPATGPTDGETPEERKRGTGPDRSKRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3F4</accession>
    <name>Q9K3F4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LPG_synthase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1287</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625574.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977544.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1287"/>
    <dbReference type="GeneID" id="1096710"/>
    <dbReference type="KEGG" id="sco:SCO1287"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1288"/>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062993_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3F4"/>
    <dbReference type="OMA" id="AGWMHDL"/>
    <dbReference type="PhylomeDB" id="Q9K3F4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB99167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="35666" checksum="69223A9439BD5709" modified="2000-10-01" version="1">MPSVLDTLAAHSDNPSSFLALNSGNAYFHDGGFDGACAYRTSGRYVLQFGGPFTAPEHRARLLDAFAAHAGRRLVAVQLQRADAELYAAHGFTVNQLGASYAVDLSRFTLRGSRFVRLRNKISRARRAGLEVAEVMAGDDCAELDRIDQCWLRDKGRHVKELRFLVGQRNGSLQRHRRLFVGRIDGETAGYINYSPVYGSRSGWLHDLSRRRPDAPPGVMEALNATVMERLTAEGAGWLHFGFTPFTGLDPEHELPGASRMFTRFARLLAERGDVIYPAASQLEYKQKWAPHVVLPEYIAFRGRPRPGAVWQLLRATNAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3T9</accession>
    <name>RL25_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name evidence="1" type="synonym">ctc</name>
        <name type="ordered locus">SCO3124</name>
        <name type="ORF">SCE66.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627341.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975690.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3T9"/>
    <dbReference type="SMR" id="Q9K3T9"/>
    <dbReference type="STRING" id="100226.SCO3124"/>
    <dbReference type="GeneID" id="1098558"/>
    <dbReference type="KEGG" id="sco:SCO3124"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3188"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K3T9"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="PhylomeDB" id="Q9K3T9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000181603" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <sequence length="198" mass="20829" checksum="62ED9E59D38EF56A" modified="2000-10-01" version="1">MSEVKLTAETRTEFGKGAARRIRRDNKVPGVLYGHGSDPLHLTLPGHELLLALRTSNVLIALDIDGKTNELAIPKSVQRDPIKGFLEHVDLQLVKRGETVSVEIPVQAEGELAPGGFLLEYVLDALPVEAEATHIPQQVTVSVAGLEAGASIHAKDIALPSGVKLDVDGDTVVLQVLSAQAEEAPAEGEGEGEGAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4E1</accession>
    <name>Q9K4E1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LMWPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5363</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629502.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030206.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5363"/>
    <dbReference type="GeneID" id="1100803"/>
    <dbReference type="KEGG" id="sco:SCO5363"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5443"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_1_0_11"/>
    <dbReference type="OMA" id="HIMFVCT"/>
    <dbReference type="PhylomeDB" id="Q9K4E1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="17651" checksum="CBCC8C4D6ED4D8D4" modified="2000-10-01" version="1">MLGGGLIVESAGTWGHEGAPMEANAETVLTDFGADPAGFTGRELLDEHVIRADLVLTATRDHRAQVISMGHSAGLRTFTLKEFTRLVNAIDPATLPPLEDGVVTRARALVRAAAALRGWLLAPTVEADEVYDPYGAPLPFFRSIGDEIHQALDPVVTALTGVPARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4G4</accession>
    <name>Q9K4G4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4174</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628350.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029485.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4174"/>
    <dbReference type="GeneID" id="1099614"/>
    <dbReference type="KEGG" id="sco:SCO4174"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4239"/>
    <dbReference type="eggNOG" id="ENOG5030569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2541018_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="83" mass="9132" checksum="6097AC224CA582D5" modified="2000-10-01" version="1">MTYDGGLPYEECRRAQRLAPRRDRAPLSPGFAMPPFHPDHPPRPAPRHKARSRRRAGLDGATVSGLLTVLCVATLLVTITFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXM7</accession>
    <name>Q9KXM7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628501.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974645.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4330"/>
    <dbReference type="GeneID" id="1099770"/>
    <dbReference type="KEGG" id="sco:SCO4330"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4399"/>
    <dbReference type="eggNOG" id="ENOG502ZBU7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035969_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KXM7"/>
    <dbReference type="OMA" id="PEWVPWS"/>
    <dbReference type="PhylomeDB" id="Q9KXM7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="308" mass="32239" checksum="96855FE946CA72D5" modified="2000-10-01" version="1">MSAATTRSRTPDRLCAEAVDLARAAAEEAAAPGVVGEHEGLVSEGDRVVTHYFACKELGYRGWRWAVTVARASRAKIVTVDEAVLLPGPDALLAPEWVPWSERLRPGDMGPGDLLPTDAEDLRLEPGWTGEDEPPPNSAVSHEMADLVEAEDAEVTAGPPAELSAVPARGTISAVAEELGLRRTRVLSRYGLHVAADRWEEGYGPKTAMAQAAPASCVSCGFLARIGGSLGQAFGVCANEFSPADGHVVSLAYGCGGHSEAAVMPKPPRVAPPVIDETRVDPFPLRPAADSGSVPVTEDQAVAELGHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-11" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXR5</accession>
    <name>CARA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="1">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">carA</name>
        <name type="synonym">pyrAA</name>
        <name type="ordered locus">SCO1484</name>
        <name type="ORF">SC9C5.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625764.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027810.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXR5"/>
    <dbReference type="SMR" id="Q9KXR5"/>
    <dbReference type="STRING" id="100226.SCO1484"/>
    <dbReference type="GeneID" id="1096910"/>
    <dbReference type="KEGG" id="sco:SCO1484"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1493"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_11"/>
    <dbReference type="InParanoid" id="Q9KXR5"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="PhylomeDB" id="Q9KXR5"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000112328" description="Carbamoyl-phosphate synthase small chain">
        <location>
            <begin position="1"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <sequence length="380" mass="40914" checksum="7F259A2DF84E6FC8" modified="2000-10-01" version="1">MTTSTRGAHRTPAVLVLEDGRIFRGRAYGAVGATFGEAVFSTGMTGYQETLTDPSYHRQVVVMTAPHVGNTGINDEDMESRRIWVSGYVVRDPARVPSNWRSTRSLDQELAAQGVVGISGIDTRALTRHLRERGAMRVGIFSGNALPDEGTMLAEVRQTPEMSGADLSAEVATTEAYVVPAIGEKKFTVAAVDLGIKGMTPHRMAERGIEVHVLPATATVDDVYAVEPDGVFFSNGPGDPATADHPVSVMQGVLERGTPLFGICFGNQILGRALGFGTFKLKYGHRGINQPVQDRTTGKVEVTAHNHGFAVDAPLDQVSDTPYGRAEVSHVCLNDNVVEGLQLLDRPAFSVQYHPEAAAGPHDAAYLFDRFVNLMEGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYA3</accession>
    <name>Q9KYA3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4999</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629151.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029992.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4999"/>
    <dbReference type="GeneID" id="1100440"/>
    <dbReference type="KEGG" id="sco:SCO4999"/>
    <dbReference type="eggNOG" id="ENOG50348H6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618061_0_0_11"/>
    <dbReference type="OMA" id="MWATLPR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="17323" checksum="3708194484924746" modified="2000-10-01" version="1">MPTTRCPAAPTYPADPTPPIPETLAYSLTLPAALASAALARATTREVLRAHGLTDMLDPALQAVGELTAVASQFTESSNYYLTLRYRFSTLRLIAYDSHPRHTSPHLATACDTRRRAALRVLACVCRACDGTWGFGEAREPGGGTRMWATLPRASAAAYGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYF2</accession>
    <name>Q9KYF2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4118</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628296.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029446.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4118"/>
    <dbReference type="GeneID" id="1099555"/>
    <dbReference type="KEGG" id="sco:SCO4118"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4179"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_0_11"/>
    <dbReference type="InParanoid" id="Q9KYF2"/>
    <dbReference type="OMA" id="SHWQAAV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="297" mass="29923" checksum="828C810ED13ADAB1" modified="2000-10-01" version="1">MHVQDSHWSSASAVAPGGAMSTAAGGAHGDAGRSAPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAEEETARLTDQARTALGQEDEPWSALSRFLRTSVASGAGRLLPPQVLRVGVSDDAGTDGGVGGPGAAAAGDPRVPQQRIQPGTGELRLVSEESAAARASAVGGSAADAAGPVATSAAGPAAGAVAGPVAGSVVGDDGAAALLEVVGRLVERARTAGELRPDVSVSDVLLVIATAAPSLPDPAQQAAASARLLDILLEGLRSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH0</accession>
    <name>Q9KYH0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2702</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626936.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028526.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2702"/>
    <dbReference type="GeneID" id="1098136"/>
    <dbReference type="KEGG" id="sco:SCO2702"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2757"/>
    <dbReference type="eggNOG" id="ENOG502ZH2Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1593657_0_0_11"/>
    <dbReference type="OMA" id="EMRTATP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176769" evidence="1">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="16916" checksum="BEFE08625E8F431C" modified="2000-10-01" version="1">MKPTTRRTLAAVVTGVAAAVGVAATPAAAARAVPVPVPLGGAETALGMELPEVAGELPVPTAGAPEGPRYVEGRLLPERTLPQLPVRAGLPGVDVRQPLPHVLGDDFDHAGVDAPAAGLRTLAPGLSLDAPLTAPNPEALGLPSPKLPEVGVLAPVVQTVPVADLGVGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYN0</accession>
    <name>Q9KYN0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LigD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7355</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631408.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031607.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7355"/>
    <dbReference type="GeneID" id="1102793"/>
    <dbReference type="KEGG" id="sco:SCO7355"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7458"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008325_5_0_11"/>
    <dbReference type="InParanoid" id="Q9KYN0"/>
    <dbReference type="OMA" id="FVVQIHD"/>
    <dbReference type="PhylomeDB" id="Q9KYN0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="2">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="22811" checksum="92A8869DA89E78F9" modified="2000-10-01" version="1">MDGEDDGLRDYHGKRDFGRTGEPAGPGAPGEGGAPGGDGPPRFVVQIHDASTLHFDFRLQVADVLKSWSVPKGPSADPRDKRLAVPTEDHPLEYEEFEGVIPAGEYGGGTVIVWDHGTYEPLSHDRRGRPVDFAESLAHGHARFRLHGAKLRGEYALTRFRGGPDGDAGADAAWLLVKTAGGGRGHGTPDPRRARSARTGRTLARVAAEHGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYP8</accession>
    <name>Q9KYP8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4484</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB92105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628649.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974466.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4484"/>
    <dbReference type="GeneID" id="1099924"/>
    <dbReference type="KEGG" id="sco:SCO4484"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4554"/>
    <dbReference type="eggNOG" id="ENOG5032WYA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126433_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KYP8"/>
    <dbReference type="OMA" id="VFHISRG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13564">
        <property type="entry name" value="DoxX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB92105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="120" mass="12371" checksum="B24DDBD038A52BFF" modified="2000-10-01" version="1">MNVAYWIVAGLLAAFYLYGGAVKAVRSRDALRPMMAWVDSTPMPAVRAIGVVEVLGAAGLVLPPLTGVAPWLAPAAAAGFVVLQIGATGVHLRLGDRQVALNLTLLATAAVTVWLAAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYY9</accession>
    <name>Q9KYY9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7540</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631584.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031734.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7540"/>
    <dbReference type="GeneID" id="1102978"/>
    <dbReference type="KEGG" id="sco:SCO7540"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7654"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KYY9"/>
    <dbReference type="OMA" id="CAREDWS"/>
    <dbReference type="PhylomeDB" id="Q9KYY9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="145"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB90898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="23853" checksum="0C4198F9BA157919" modified="2000-10-01" version="1">MKHQRVRDLMSDAVVRVQRGTPFKEIAHLLLEYDITAVPVVDEENRPVGVVSEADLLQKMWGGEPDGSAEHAEWSRASAGKADATDAAGLMTSPPLCALESWSVVDAARVMARHRIKRLLVVDGDGRLAGVVSRSDLLRVFLRTDRAIRTEIIEEALVKALGLAPSSVQVDVAHGHVVLSGRLPAHVSAPLLEEHCRSVDGVVAVEFRPAGEADAEGPAAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZC3</accession>
    <name>Q9KZC3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631032.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031343.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6966"/>
    <dbReference type="ESTHER" id="strco-SC6F7.19C">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="GeneID" id="1102404"/>
    <dbReference type="KEGG" id="sco:SCO6966"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7066"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_11"/>
    <dbReference type="InParanoid" id="Q9KZC3"/>
    <dbReference type="OMA" id="KPRWPIP"/>
    <dbReference type="PhylomeDB" id="Q9KZC3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="28923" checksum="AA2241A216864A69" modified="2000-10-01" version="1">MAEAREHTLTGTRGRIAVREWPAVRPRYVALLVHGYGEHTGRYEEVAGVLTGHGAAVYAPDHTGHGRSDGERVVVEDFEDVVTDVHAVADLARAGHPGLPVVMVGHSMGGLIASRYAQRHPGELTALVLSGPVIGDWELPRRLLALEEIPDTPISPASLSRDPAVGAAYAADPLVWHGPMKRPTLRAFVRTLETVAEGGDVGPLPLLWVHGDDDRLVPLPGSRVGVEPLSGGDLTVRIYPGARHEVFNETNRAEVFADVTRFLDGVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZC5</accession>
    <name>Q9KZC5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6964</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631030.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031342.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6964"/>
    <dbReference type="GeneID" id="1102402"/>
    <dbReference type="KEGG" id="sco:SCO6964"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7064"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050554_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZC5"/>
    <dbReference type="OMA" id="EVQDVWT"/>
    <dbReference type="PhylomeDB" id="Q9KZC5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="23810" checksum="DDD7C717D60F7AA7" modified="2000-10-01" version="1">MGRDQRRTVRELVDAHGRTYAEEAGIRLKDTPQPLYRLLVLAHLLSARISASIAVAAARALSEAGLRDPRRMAGATWQQRVDALGRGGYRRYDERTATQLGEAAELLTERWGGDLRRLRDEADGDVSELRRLLQEFPGMGPTGADIFLREAQLVWPETGPLLDRKALRGAERLDLPGDRDRLLALAGKTEPAVLAAALVRAAVDKEVAEDTLDRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZG2</accession>
    <name>Q9KZG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6990</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031361.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6990"/>
    <dbReference type="GeneID" id="1102428"/>
    <dbReference type="KEGG" id="sco:SCO6990"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7091"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034788_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZG2"/>
    <dbReference type="OMA" id="QFTIMPL"/>
    <dbReference type="PhylomeDB" id="Q9KZG2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="33352" checksum="377F0B10A8140E5D" modified="2000-10-01" version="1">MRTESTANNEHDEHLGADPTGDRSARRAVTVFPVLVLLAGALGLLLPGSFTGWSEAVPYLLGVVMFCMGITMTPEDFRGVVKRPWAVALGLVAHYVIMPGLGWAIAHLLDLPPQLAAGVILVGCAPSGTASNVVTYLARGDVALSVSVATVSTLVAPLVTPPLTLLLAGEYLPVDAGSMVTDILKTVLLPVLAGVVVRLLAGRYVQRALPALPWLSALTISVIVAVVVAGSADAIKSAAGLVFVAVVLHNGLGLALGYGAGRLGRLGEPGSRAMAFEVGMQNSGLAASLATAHFSPLAALPAAVFSVWHNVSGAVVAAWLSRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZY4</accession>
    <name>Q9KZY4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4442</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628609.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974539.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4442"/>
    <dbReference type="GeneID" id="1099882"/>
    <dbReference type="KEGG" id="sco:SCO4442"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4512"/>
    <dbReference type="eggNOG" id="ENOG5034547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="NNGACVM"/>
    <dbReference type="PhylomeDB" id="Q9KZY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="6484" checksum="570FC37A7AC82800" modified="2000-10-01" version="1">MAILQGAQESWTKSSYSGGNGACVEVRSPLVAALAVRDSKVTGGPVLAFPADAWTAFVTSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L015</accession>
    <name>Q9L015_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2298</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626546.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028260.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2298"/>
    <dbReference type="GeneID" id="1097732"/>
    <dbReference type="KEGG" id="sco:SCO2298"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2335"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L015"/>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="PhylomeDB" id="Q9L015"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="219" mass="21941" checksum="25448C76FF13BEA4" modified="2000-10-01" version="1">MSSPLPSSPAASVLDLAPVVPVVVVDDLADAVPLARALVAGGLPAIEVTLRTPVALDAIRAIAGEVPDAVVGAGTVVTAEQVGEVVAAGARFLVSPGWTDTLVEAMRGSGVPFLPGVSTASEVVALLERGVREMKFFPAEAAGGTAYLKALAAPLPQARFCPTGGITPASAPEYLALPNVGCVGGSWMLPKDAIAGRDWARVEALAREAAALSAGGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L054</accession>
    <name>Q9L054_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2981</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627204.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975830.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2981"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1098414"/>
    <dbReference type="KEGG" id="sco:SCO2981"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3040"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003394_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L054"/>
    <dbReference type="OMA" id="DCSPDAC"/>
    <dbReference type="PhylomeDB" id="Q9L054"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="722"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB87331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="765" mass="85044" checksum="F8EC031706F9B6D6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0M4</accession>
    <name>Y4636_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein SCO4636</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4636</name>
        <name type="ORF">SCD82.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628797.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029784.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0M4"/>
    <dbReference type="SMR" id="Q9L0M4"/>
    <dbReference type="STRING" id="100226.SCO4636"/>
    <dbReference type="GeneID" id="1100077"/>
    <dbReference type="KEGG" id="sco:SCO4636"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4707"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116276_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0M4"/>
    <dbReference type="OMA" id="MITTRAE"/>
    <dbReference type="PhylomeDB" id="Q9L0M4"/>
    <dbReference type="BRENDA" id="4.2.1.59">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000216147" description="UPF0336 protein SCO4636">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <sequence length="150" mass="16152" checksum="68D9C1A58DCA3D04" modified="2000-10-01" version="1">MALDQSLVGRSYPPTAPYEVGREKIREFAEAVGDANPAYTDAEAAKALGHPDVIAPPTFVFSITFKAAGQVIEDPQLGLDYSRVVHGDQKFSYARPVRAGDRLTVTSTIEAIKSMAGNDILDIRGEVHDEAGEHVVTAWTKLVARAAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0M7</accession>
    <name>Q9L0M7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4633</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628794.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029782.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4633"/>
    <dbReference type="GeneID" id="1100074"/>
    <dbReference type="KEGG" id="sco:SCO4633"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4704"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L0M7"/>
    <dbReference type="OMA" id="DWVVWSA"/>
    <dbReference type="PhylomeDB" id="Q9L0M7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="22237" checksum="B4A4015A543A6428" modified="2000-10-01" version="1">MRIVIAGGHGQIALRLERLLAARGDEVAGIVRKAEQADDLRAAGAEPVVLDLESASVEEVAERLRGADAAVFAAGAGPGSGVARKDTVDKAAAVLFADAAVRAGVRRFLIVSSMGADPGHQGDEIFDVYLRAKGEADAYVSSLDALDWTILRPGALTDDAGTGLVRLEAHTGRGPVPRDDVAAVLAELVDTPATNGLALELISGSAPVSVAVKSVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1S5</accession>
    <name>Q9L1S5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627194.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975842.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2970"/>
    <dbReference type="GeneID" id="1098403"/>
    <dbReference type="KEGG" id="sco:SCO2970"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3028"/>
    <dbReference type="eggNOG" id="ENOG502ZDJI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207336_0_0_11"/>
    <dbReference type="OMA" id="CANCAAP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6886" checksum="A583DC0BAB6FF5BF" modified="2000-10-01" version="1">MTYDRLVCANCAAPVSEGRCPVCRANRERLQQESNFFAGLNPTTLIALLAVLIAAVALLAHQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L246</accession>
    <name>Q9L246_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2675</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626910.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976124.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2675"/>
    <dbReference type="GeneID" id="1098109"/>
    <dbReference type="KEGG" id="sco:SCO2675"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2730"/>
    <dbReference type="eggNOG" id="ENOG5032UNB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083318_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L246"/>
    <dbReference type="OMA" id="DPGFAMD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016601">
        <property type="entry name" value="UCP012637"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012637">
        <property type="entry name" value="UCP012637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="24927" checksum="AEFAB604395B86AE" modified="2000-10-01" version="1">MLHLADEGEAADLAAFLSRLLHYDRSAAVRLQAAGTALAVFGRPPSFEVLAVRAVRLAKPYENGLDDTLDVTVSAGELLESVDEQAATSVVPGPVTGPPWAGVLPPRGGWRTEAGLPGPDALRALVAAAVAEFRTRMEELTPEDRTRAELDRVGREIWSRTVGETGLPVRAVHAAQSLGFLRTRRTPPGSEAGAGSGAGLGEDAPKLLSSGAWLRLRTPFGSVALRRAGTGALGISVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2G4</accession>
    <name>Q9L2G4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2519</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626759.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028402.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2519"/>
    <dbReference type="GeneID" id="1097953"/>
    <dbReference type="KEGG" id="sco:SCO2519"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2564"/>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005108_4_1_11"/>
    <dbReference type="InParanoid" id="Q9L2G4"/>
    <dbReference type="OMA" id="GIFLMHR"/>
    <dbReference type="PhylomeDB" id="Q9L2G4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="211"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB69740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="692" mass="71731" checksum="A1B548AC4C13CDD9" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9R7V6</accession>
    <name>Q9R7V6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5541</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29071">
        <property type="entry name" value="T29071"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629675.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5541"/>
    <dbReference type="DNASU" id="1100981"/>
    <dbReference type="GeneID" id="1100981"/>
    <dbReference type="KEGG" id="sco:SCO5541"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5629"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="Q9R7V6"/>
    <dbReference type="OMA" id="QCFPAVD"/>
    <dbReference type="PhylomeDB" id="Q9R7V6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="18839" checksum="F0B479F947DCC58E" modified="2000-05-01" version="1">MVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHAGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLCDTRRLADCFPAVDYFENSGLPFVVALNGFDGQQPYSPDEVREALQIGPDTPIITTDARHRADAKSALITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD92</accession>
    <name>Q9RD92_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2859</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB65589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975942.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2859"/>
    <dbReference type="GeneID" id="1098293"/>
    <dbReference type="KEGG" id="sco:SCO2859"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2919"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RD92"/>
    <dbReference type="OMA" id="YRWEEST"/>
    <dbReference type="PhylomeDB" id="Q9RD92"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="125" mass="13713" checksum="55C3B29C64664107" modified="2000-05-01" version="1">MEPGDPTKQARAAAQLRKGVLEYCVLALMRDRPRYGVELLHALEESGALATSQGTVYPLLSRLRREDLVTTTWQESASGPPRRYYALTATGRAALDEFTHVWPGFRDAVDAFLATTPHPSAGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ8</accession>
    <name>Q9RDJ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028439.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2588"/>
    <dbReference type="GeneID" id="1098022"/>
    <dbReference type="KEGG" id="sco:SCO2588"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2634"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023991_1_0_11"/>
    <dbReference type="OMA" id="AYQANMW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="719" mass="77039" checksum="779953550527E95E" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDM9</accession>
    <name>Q9RDM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626654.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028334.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2408"/>
    <dbReference type="GeneID" id="1097842"/>
    <dbReference type="KEGG" id="sco:SCO2408"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2449"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_5_11"/>
    <dbReference type="InParanoid" id="Q9RDM9"/>
    <dbReference type="OMA" id="KRVDMFP"/>
    <dbReference type="PhylomeDB" id="Q9RDM9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="541" mass="56702" checksum="A1A39802C8590DAB" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDQ7</accession>
    <name>Q9RDQ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2377</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626623.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028313.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2377"/>
    <dbReference type="GeneID" id="1097811"/>
    <dbReference type="KEGG" id="sco:SCO2377"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2418"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RDQ7"/>
    <dbReference type="OMA" id="MRHPANI"/>
    <dbReference type="PhylomeDB" id="Q9RDQ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004033">
        <property type="term" value="F:aldo-keto reductase (NADP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="338" mass="36536" checksum="1FEA41F8916BD896" modified="2000-05-01" version="1">MTDSRIPTARLGTDGPEVGAQGLGCMGMSFAYGPTDTEASRATLERALELGVTLYDTADAYGAGENERFLAPFFKAHRDEVVVATKFALSIPPDDPTKRIIRNDAPYIREAVEASLRRLDLDVIDLYYMHRRDVNVPIEETVAVMADLVREGKVKQLGLSEVTGDELRAAQTVHPIAAVQSEWSLFSRDIEAGVVPAARELGVTLVPYSPLGRGFLTGSFANAEQDLTDGDFRRQQPRFTGDNAAANAALLTPVRALAEAHDATLGQIALAWVQQRAQVHGLPVIPIPGTRKPARVAENTAATRLVLTEAELSLLEPIAEKVAGDRYADMTFASAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIX0</accession>
    <name>Q9RIX0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0143</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624481.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026881.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0143"/>
    <dbReference type="GeneID" id="1095567"/>
    <dbReference type="KEGG" id="sco:SCO0143"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.121"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_7_11"/>
    <dbReference type="InParanoid" id="Q9RIX0"/>
    <dbReference type="OMA" id="YDNGPAA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="18386" checksum="10B7DAD7CB73639B" modified="2000-05-01" version="1">MTDRSSSAWLAAMGRPRAFDEDEAVRAAVTLFGGRAYDGVSVDDLVSHLGVHRNSLYKTFGSKRGLYLTALRRHLADDVGPLLDALADAPDAAAALRLVTSADLGLLLLAITERAPVDDEVAAEVNAALAAVDRAVADALGVSADLATAVTAAALGIVLRGNPDNAATALAQRLSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIX3</accession>
    <name>Q9RIX3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative merR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0140</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624478.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026878.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0140"/>
    <dbReference type="GeneID" id="1095564"/>
    <dbReference type="KEGG" id="sco:SCO0140"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.117"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065103_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RIX3"/>
    <dbReference type="OMA" id="HYDKEEI"/>
    <dbReference type="PhylomeDB" id="Q9RIX3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="30944" checksum="05F88EFA872598D4" modified="2000-05-01" version="1">MADRLTIGEFSRITHLSIRMLRRYHEQDLLVPAEVDPDTGYRYYSPAQIRPALTVRRFRDLDLPLADLRRFLAAESADGPDDGTAQQVVAAHLRRLEDRLGRTQRAVEVLRELLDPEAERAVTLEELPARRVLAVTLDVPEGAGLDWYDEAMCDVDSAAGERSVLPPGGRYEHTLFTEGHGRATVYVPFEAPLPPEMPGRVRELHLPRRTAAVATHQGRHDDLDLTYGAVGSFAARNDLRSQDLVEEVYLVGPRDTDRPELWRTLVAWLIAPENG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ61</accession>
    <name>PAFA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pup--protein ligase</fullName>
            <ecNumber evidence="1">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pafA</name>
        <name type="ordered locus">SCO1640</name>
        <name type="ORF">SCI41.23c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625915.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977186.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ61"/>
    <dbReference type="SMR" id="Q9RJ61"/>
    <dbReference type="STRING" id="100226.SCO1640"/>
    <dbReference type="GeneID" id="1097071"/>
    <dbReference type="KEGG" id="sco:SCO1640"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1655"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040524_0_1_11"/>
    <dbReference type="InParanoid" id="Q9RJ61"/>
    <dbReference type="OMA" id="CVSQRAE"/>
    <dbReference type="PhylomeDB" id="Q9RJ61"/>
    <dbReference type="BRENDA" id="6.3.1.19">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000395956" description="Pup--protein ligase">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <sequence length="453" mass="52096" checksum="C75DAA7BD95A2E10" modified="2000-05-01" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNVTELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADILIPFLVTRQLLCGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTMLLKVGATDLVLRMIEAGTVMRDLTLENPIRAIREVSHDITGRRKVRLASGREASALEVQREYYEKAVDFCERRGIRTGTVERVLELWGRTLDAIEAEDLDRIGTEIDWVMKYKLLERYRAKHNMTMSHPRVAQIDLAYHDIHRRRGLYYLLEKKGQAARVANDLKIFEGKSVPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ86</accession>
    <name>Q9RJ86_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624988.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978184.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0679"/>
    <dbReference type="GeneID" id="1096102"/>
    <dbReference type="KEGG" id="sco:SCO0679"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.665"/>
    <dbReference type="eggNOG" id="ENOG502ZU24">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202636_0_1_11"/>
    <dbReference type="OMA" id="RIKQFAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="71" mass="7829" checksum="686A8990AE31BECC" modified="2000-05-01" version="1">MSGGAVGTSTAGQNATSSTRRNVMAGVLDRIKQFARSPQGRRAAEQVRRAASDPRRRAQAQEMLRRFGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJV7</accession>
    <name>Q9RJV7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative binding protein dependent transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0353</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027045.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0353"/>
    <dbReference type="GeneID" id="1095776"/>
    <dbReference type="KEGG" id="sco:SCO0353"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.328"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RJV7"/>
    <dbReference type="OMA" id="WISFFTG"/>
    <dbReference type="PhylomeDB" id="Q9RJV7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB55715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="32476" checksum="D5C6B640961DF1FD" modified="2000-05-01" version="1">MEQTSVSKPRAWRDLGARVSMVVPAVLVYVALLVVPVIYAIYYSFTEYNGFPHRVPEFIGLDNYRTMFGSDDITGTMVVTAVVAVVGAVAVNLAALGLALLLQRTNRFNTFGRVVMFYPHVLSALVVGFLWQAILGPQGVVNTMLEKAGTDSLPFLSDPDWALWSMILVIVWSLFGVQLILYLAGLQAVPADLLEAARIDGASRWQTFRAVTWPSLASTVTVAVITSGISLLKTYDVVVSLTGGGPAGSTKTLAYSILAVSFPQRDIGVASAQAVLLIVAAAVLAITVLVLRRRAEDDAESIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK60</accession>
    <name>Q9RK60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624864.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027196.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095973"/>
    <dbReference type="KEGG" id="sco:SCO0550"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.531"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048111_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RK60"/>
    <dbReference type="OMA" id="GSPWAMM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="173"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="28169" checksum="B8A60B7127BCD5C2" modified="2000-05-01" version="1">MGSRRAARPSRSHARPRGGLRSRGAALALGAVTLTAGVGITLAVGDGDDGGASDRVTANAADQASNAEEAAGGAAPLASASASPSATAGRSPSPSAEPKRTPTKTASPATSAPKASAPASKAPVRATAKSGGDRSGGGGSGSGSGSSGGSGSGSGPGSGSGSGSTGGAEAQVLALVNEERAAAGCSPVTANSRLTRAADDYSDVMASSGVMSHTGPDGSTMASRVEAAGYQWSALGENIAQGQADAASVMEAWMNSPGHRENILNCSFKELGVGVHFGDGGPWWTQDFGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKF6</accession>
    <name>Q9RKF6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3481</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627684.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029020.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000041.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKF6"/>
    <dbReference type="STRING" id="100226.SCO3481"/>
    <dbReference type="DNASU" id="1098918"/>
    <dbReference type="GeneID" id="1098918"/>
    <dbReference type="KEGG" id="sco:SCO3481"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3540"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051848_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKF6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="370" mass="41113" checksum="43B0BB191CECE4D4" modified="2000-05-01" version="1">MTMPAESAATVRGRRYPADPEWFCDFRTFPVQGLGPEVGVHRRDPSSVLTVDGRYHVWYTRSTGETDGFGTGDPMAKVFPWDWSEIWHATSDDGATWVEQGRALGRGEPGSYDDRSVFTPEVLEHQGWFYLVYQVIRSPYALRSFESIAMAKAPSPDGPWVRSPQPILRPQADGEWAGEEDNRLSVVSQGSFDSHKVHDPILVPFQGRFFLYYKGEQMGEGFSAGGRTTRWGLAIADDIEGPYHRCPANPVTNSGHETCVWRYGDGIAAMLTTDGPERNTIQFAPDGINFEIMAHIANPPVATGPLRLPDHAVAPLDGVRWGLCHDVTASWHYIQGFAADERQKMFYTRGLSPETAESAEADALPAPHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKL5</accession>
    <name>Q9RKL5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ordered locus">SCO4067</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628248.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029416.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4067"/>
    <dbReference type="GeneID" id="1099504"/>
    <dbReference type="KEGG" id="sco:SCO4067"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4126"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_3_5_11"/>
    <dbReference type="InParanoid" id="Q9RKL5"/>
    <dbReference type="OMA" id="PGHIVSH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB56347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="784" mass="78600" checksum="9AAE92AB1C6370B9" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKM9</accession>
    <name>Q9RKM9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4098</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628278.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029430.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4098"/>
    <dbReference type="GeneID" id="1099535"/>
    <dbReference type="KEGG" id="sco:SCO4098"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4157"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_5_3_11"/>
    <dbReference type="InParanoid" id="Q9RKM9"/>
    <dbReference type="OMA" id="HRMDGPS"/>
    <dbReference type="PhylomeDB" id="Q9RKM9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="23525" checksum="74B4B3F1579753A8" modified="2000-05-01" version="1">MPEQPRVVLLKPLVKSPLIEVGDFSYYDDPDDATAFETRNVLYHYGPEKLVIGKFCALGTGTRFIMNGANHRMDGPSTFPFPTMGGSWAEHFDLLTGLPNPGDTVVGNDVWFGNGATVMPGVRIGHGAIIATGAVVTSDVPDYGIVGGNPARLIRKRHPERDIARLLAVAWWDWPVEQITAHVRTIMSGTVTQLEEAAARTKRTPAQSCREPGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKU1</accession>
    <name>Q9RKU1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030768.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6251"/>
    <dbReference type="GeneID" id="1101692"/>
    <dbReference type="KEGG" id="sco:SCO6251"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6365"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RKU1"/>
    <dbReference type="OMA" id="PQYNWSV"/>
    <dbReference type="PhylomeDB" id="Q9RKU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB60170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="20311" checksum="5EE08901E9237EE2" modified="2000-05-01" version="1">MTEVAIVIGSTGPRRVGEAVARWVHELAAKRGDAEFELVDLKDYDLPHLDEMMPAAMGQYSQPHTRAWAEKVAGFDAFVFVTPEYNHSTTGALKNAIDFLHAEWHNKAAGFVSYGSNGGVRAVEHLRLVLGELQVADVQAQVALSVFTDFEHFTAFKPGEHHEATLNTMLAQVVAWGEALAPLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKX6</accession>
    <name>Q9RKX6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977408.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1417"/>
    <dbReference type="GeneID" id="1096843"/>
    <dbReference type="KEGG" id="sco:SCO1417"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1427"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKX6"/>
    <dbReference type="OMA" id="MPEQIMV"/>
    <dbReference type="PhylomeDB" id="Q9RKX6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="500" mass="53055" checksum="2B6BC603D71F1195" modified="2000-05-01" version="1">MAQWTSAVGAGQLARLLGSQQDRPAGPGTRRPPAYRALADGIRLLVLEGRVPVAARLPAERELALALTVSRTTVAAAYEALRAEGFLESRRGAGSWTAVPAGNPLPARGLEPLPPEALGSVIDLGCAALPAPEPWLTRAVQGALEELPPYAHTHGDYPAGLPALRAMIAERYTARGIPTMPEQIMVTTGAMGAIDAICHLFGGRGERIAVESPSYANILQLMREAGARLVPVAMAEGLTGWDVDRWRQVLRDAAPRIAYVVADFHNPTGALADDDQRRRLVDAARSAGTVLVADETMSELWLDEDVEMPRPVCAFDPAGSTVITVGSASKAFWAGMRIGWVRAAPDVIRSLVAARAYADLGTPVLEQLAVNWLFSTGGWEQAVTVRREQARQNRDELVAAVRRELPDWEFEVPRGGLTLWVRTGGLSGSRLAEAGERVGVRVPSGPRFGVDGAFEGYVRLPFTVGGAVAEEAAVRLAAAARLVESGGVGGGGEAPRTFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL63</accession>
    <name>Q9RL63_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0423</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
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                <person name="Quail M.A."/>
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                <person name="Chen C.W."/>
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                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
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                <person name="Sharp S."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
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        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176967" evidence="1">
        <location>
            <begin position="39"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="84"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB54171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="17590" checksum="E73C05D717D4E970" modified="2000-05-01" version="1">MQRVPTTLRTRTGLLGALALLFAAGLTASPMMTAPAHAAYGPCNTTVKRTDGLGSGGVPGNHYKIPARTGNGLSCYMEYGTGSDNAVTALQRAIVSCYDGTYAARRIIDTGGADGSYGTGTEDAVRWLQANRLGVSADGDYGPATREQMRWPLYTAGGTYISCLNPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2P5</accession>
    <name>Q9S2P5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2191</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35307">
        <property type="entry name" value="T35307"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626444.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028190.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2191"/>
    <dbReference type="GeneID" id="1097624"/>
    <dbReference type="KEGG" id="sco:SCO2191"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2228"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039679_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2P5"/>
    <dbReference type="OMA" id="DFHPVTV"/>
    <dbReference type="PhylomeDB" id="Q9S2P5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB51275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="467" mass="48236" checksum="5C49D6EB850FB423" modified="2000-05-01" version="1">MLEPAYQADVVVVGAGIAGLAAAQRLTSAGVTTTVLEAAHAVGGRMATEKVDGFRLDRIGQLLSTAYPELRRTPGLDGLALLPFAPGVLLHSEGRHHHAGAPSGVRSARGALHAVRALASAPRSMPAPRRTVNAPGTSGRPAAAPRSRAGAPLGTAVDQARLGAALARLAHTPAERLLARPELPAARALAARGLPARTIDGFLRPLLAALLYDPDLTTSSRCADLALRAFAGGRLTLPEGGAEALPEHMARSLPPGTVHTGVRVTSVATNAVTTAEHGVIRCRAVLVATDARAAAELLPGLRVPDFHPVTVVHHTTDEPPTTGAALLLDADRGGPVAHTAQVSQVDPSRAPAGRTLVSSTVLGPPPPDLDTAVRIHLSRLYGTPTTRWETLAVHHTPEAVPAMRPPHDPRRPVRLLAGLYVCGDHRDTSTAQGALHSGHRASAAILRDLGAGRPMHSAEPAPTAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2S8</accession>
    <name>Q9S2S8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2061</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35090">
        <property type="entry name" value="T35090"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626321.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028123.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2061"/>
    <dbReference type="GeneID" id="1097495"/>
    <dbReference type="KEGG" id="sco:SCO2061"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2093"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9S2S8"/>
    <dbReference type="OMA" id="VWRERAP"/>
    <dbReference type="PhylomeDB" id="Q9S2S8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB51453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="34696" checksum="EE76CC1E7479D3C8" modified="2000-05-01" version="1">MCVVRSLTKTYPAVRGRRGVPAAPEVRATDDVTLDIRRGEIFGLLGPNGAGKSTLVRQLTGLMRPDGGSVEILGHDIVRHPERAARILAYLGQESSALDELTVSLAAETTGRLRGLEVRRARAERDAVLEELGLTGLAGRPIKKLSGGQRRLACFAAALVGERPLLVLDEPTTGMDPVARRAVWSAVDRRRAEHGATVLLVTHNVIEAETVLDRVAVLDRGRVIACDTPAGLKEQVAGEVRVDLVWRESAPLNVPEVAALRDRVVESGRRWTLRLAPEEARAVVATVTGGAAFAALDDFTLATPSLEDVYLALGGAARQGLVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2V8</accession>
    <name>Q9S2V8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2098</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34968">
        <property type="entry name" value="T34968"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626357.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028138.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S2V8"/>
    <dbReference type="STRING" id="100226.SCO2098"/>
    <dbReference type="GeneID" id="1097532"/>
    <dbReference type="KEGG" id="sco:SCO2098"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2132"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061533_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S2V8"/>
    <dbReference type="OMA" id="CHGVLEY"/>
    <dbReference type="PhylomeDB" id="Q9S2V8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097697">
        <property type="term" value="F:tRNA 5-carboxymethoxyuridine methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="2">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="28035" checksum="FBBE9209052CE8E3" modified="2000-05-01" version="1">MRPPASHPRPHTAVSRSEPSRSRAALRTAVVWDVLQDALDRRVKATGRPTLDVLDTGGGSGNFAVPVAGLGHRVTVVDPSPNALFALERRAAEAGVADRVRGVQGDARGLFDVAERGGYDAVLCHGVLEYVDDPAEGVRNAVAALREDGVLSLLAAGLGGAVLARALAGHFTEARQALADPDGRWGTGDPVPRRFTAEQLTGLVEAAGLRIGAVHGVRVFADLVPGVLVDTEPGAMDALLKLEAAAAELAAFHSVATQLHVLGETRGAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Q7</accession>
    <name>Q9X7Q7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6751</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35276">
        <property type="entry name" value="T35276"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630824.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972246.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6751"/>
    <dbReference type="GeneID" id="1102190"/>
    <dbReference type="KEGG" id="sco:SCO6751"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6858"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7Q7"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="PhylomeDB" id="Q9X7Q7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071577">
        <property type="term" value="P:zinc ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB40701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="312" mass="32580" checksum="1F0F44DFB326ADA5" modified="1999-11-01" version="1">MGAGHDHGHAHGGHAGGTATAAYRGRLRVALSITLTVMVVEIVGGLVADSLALIADAAHMATDALGLGMALLAVHFASRPPSDRRTFGYARAEILAALANCLLLLGVGGYVLYEAIDRFVTPADTAAGPTVVFGAIGLVANMVSLSLLMRGQKESLNVRGAFLEVAADALGSLAVIVSALVILATGWQPADPIASLLIGLMIVPRTLRLLRETLDVLLEAAPKGVDIAEVRAHILALDGVEDVHDLHAWTITSGMPVLSAHVVVDGEALSAIGHEKMLHELQGCLGDHFDVEHCTFQLEPSGHAEHEARLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7T3</accession>
    <name>Q9X7T3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7267</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35341">
        <property type="entry name" value="T35341"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031553.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7267"/>
    <dbReference type="GeneID" id="1102705"/>
    <dbReference type="KEGG" id="sco:SCO7267"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7369"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_1_11"/>
    <dbReference type="InParanoid" id="Q9X7T3"/>
    <dbReference type="OMA" id="GFFLHTD"/>
    <dbReference type="PhylomeDB" id="Q9X7T3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="14430" checksum="8274B1A2BAB9945A" modified="1999-11-01" version="1">MTRIALVALVVDDYDEAIRFYTEALGFRLAEDTPRPDGSRWVVVEPGGPDAGTALLLARAKGEAQRARVGDQTGGRVGFFLHTDDFARDHARMTAAGVTFLEEPRHEPYGSVAVFQDLYGNRWDLLQPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7W1</accession>
    <name>Q9X7W1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6766</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35406">
        <property type="entry name" value="T35406"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630838.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972231.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X7W1"/>
    <dbReference type="STRING" id="100226.SCO6766"/>
    <dbReference type="GeneID" id="1102205"/>
    <dbReference type="KEGG" id="sco:SCO6766"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6875"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052502_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7W1"/>
    <dbReference type="OMA" id="FNTDTPQ"/>
    <dbReference type="PhylomeDB" id="Q9X7W1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="38650" checksum="F7C3B4239E1924E6" modified="1999-11-01" version="1">MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVFLCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGFRVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTRELFKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVPTYRELIEKTDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAMRETVSGNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8D2</accession>
    <name>Q9X8D2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">KorSA, regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3259</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36219">
        <property type="entry name" value="T36219"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627471.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028866.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3259"/>
    <dbReference type="GeneID" id="1098693"/>
    <dbReference type="KEGG" id="sco:SCO3259"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3323"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_1_11"/>
    <dbReference type="OMA" id="LYIERET"/>
    <dbReference type="PhylomeDB" id="Q9X8D2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="27825" checksum="35D5CA957FD16782" modified="1999-11-01" version="1">MGTAVEGGRSGPRYVQIADEIVQQIRAGVLKPGDMVPSESELVDRYGVSGGTIRKAMVEVRASGLVETRHGKGSIVKDRPPVRHRSSDRFRRSLRQGGKAAYLAESAQSGATAKVSVLYIGPMEAPADAAQRLGLPAGTQVLARRRLYFRNGTPVETASSYLPWDVVKDIPELFAENPGGGGIYARLEDHGHEFAEFVETLQARPASKAEASELALSPGAPVVHLIREARTTAGVVVEVCDTLMAADQFVFEYRIPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9T7</accession>
    <name>Q9X9T7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3931</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37184">
        <property type="entry name" value="T37184"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628116.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029318.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1099367"/>
    <dbReference type="KEGG" id="sco:SCO3931"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4003"/>
    <dbReference type="eggNOG" id="ENOG5031P6C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2275971_0_0_11"/>
    <dbReference type="OMA" id="EWRVARE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB46969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="99" mass="10322" checksum="96390F4FA44B824E" modified="1999-11-01" version="1">MTGAGDSWLHDGLDGVAGVESGLWVRGVDYVGGWRSARESADRLNRALLGAGFELSAVRAVASADETGRGVVRLAGWPETADRLAVLLEALADRDDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Y1</accession>
    <name>Q9X9Y1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1891</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36905">
        <property type="entry name" value="T36905"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626157.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028034.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1891"/>
    <dbReference type="GeneID" id="1097325"/>
    <dbReference type="KEGG" id="sco:SCO1891"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1916"/>
    <dbReference type="eggNOG" id="ENOG5032B92">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051661_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X9Y1"/>
    <dbReference type="OMA" id="WTGMTRA"/>
    <dbReference type="PhylomeDB" id="Q9X9Y1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="20758" checksum="A95700BFBA1EB8FA" modified="1999-11-01" version="1">MTAETTTLDLGPQTRVLTRLADGVREDRLADPTPCPGLAVRNLLGHLTGLAVAFRDAARKDLGPTTDTSPEASVPDVGPGWREELAAALGELAEAWRDPEAWTGMTRAGGIDLPGEVAGAVVADELVIHGWDLARATGQEYAPDAAALRAAHGLLAAAAEESERDQGMFGPVVAVPADAPLLERAVGLSGRDPDWTRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAB9</accession>
    <name>Q9XAB9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ordered locus">SCO1937</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36009">
        <property type="entry name" value="T36009"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626202.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976881.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1937"/>
    <dbReference type="GeneID" id="1097371"/>
    <dbReference type="KEGG" id="sco:SCO1937"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1964"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_11"/>
    <dbReference type="InParanoid" id="Q9XAB9"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="PhylomeDB" id="Q9XAB9"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="210"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB50762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="56607" checksum="68317DC3002D80FC" modified="1999-11-01" version="1">MSSSNPLRDPADRRLPRIAGPSGLVIFGVTGDLSRKKLMPAVYDLANRGLLPPGFSLVGFARRDWEHEDFAQVVHDAVKEHSRTPFREEVWQQLIQGMRFVQGTFDDDDAFERLRGTIEELDKAQGTGGNFAFYLSVPPKSFPVVIQQLKKHGLADQTNGSWRRAVIEKPFGHDLKSAEELNAIVHEVFGSDQVFRIDHYLGKETVQNILALRFANTMFEPIWNRSYVDHIQITMAEDIGIGGRAGYYDGIGAARDVIQNHLLQLLALTAMEEPASFDADALAAEKTKVLGAVRLPKDLGRDTVRGQYAAGWQGGAKAVGYLEEDGIDPKSKTDTYAAIKVGIDNRRWAGVPFYLRTGKRLGRRVTEIAVVFQRAPHSPFDTTATEELGSNAIVIRVQPDEGVTVRFGSKVPGTSMEIRDVSMDFAYGESFTESSPEAYERLILDVLLGDANLFPRTEEVELSWKILDPIEEYWDEHGTPAQYPAGTWGPVEADDMLERDGRSWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAD0</accession>
    <name>Q9XAD0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35998">
        <property type="entry name" value="T35998"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626191.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976893.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1926"/>
    <dbReference type="GeneID" id="1097360"/>
    <dbReference type="KEGG" id="sco:SCO1926"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1952"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078469_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAD0"/>
    <dbReference type="OMA" id="LCQGHCP"/>
    <dbReference type="PhylomeDB" id="Q9XAD0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB50751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="252" mass="26850" checksum="98E69AC1819323EF" modified="1999-11-01" version="1">MKNVGEAPQEELATGERSTRNRVARSILDHGPSTVAELAGRLGLTQAAVRRHLDALVADDVVEPREQRVYGARTRGRPAKVFALTDCGRDAFDQSYDKLAADALRWIAEQEGGEQAIAAFARARIAAQSGAYRAAVESVPAEKRAEALAKALSEDGYAATARSAPHPQQGEQLCQHHCPVAHVAEQFPQLCEAETEFFAELLGTHVQRLATIAHGDGVCTTFIPKTSHAPPPARASENTANASASTAGRNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAD3</accession>
    <name>Q9XAD3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dioxygenase ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1923</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35995">
        <property type="entry name" value="T35995"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626188.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976896.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1923"/>
    <dbReference type="GeneID" id="1097357"/>
    <dbReference type="KEGG" id="sco:SCO1923"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1949"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_2_11"/>
    <dbReference type="InParanoid" id="Q9XAD3"/>
    <dbReference type="OMA" id="TLECWLH"/>
    <dbReference type="PhylomeDB" id="Q9XAD3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB50748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="105" mass="11548" checksum="6697AE5E60503C14" modified="1999-11-01" version="1">MTFVRVCGADELEEDTPKRVELDGTPISVVRTEGELFAIHDICSHANVSLAEGEVDDCHIECWLHGSRFDLRSGKPDSLPATRPVPVYPVKIEGDDVLVSLTQES</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAJ4</accession>
    <name>Q9XAJ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35376">
        <property type="entry name" value="T35376"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627803.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975331.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3608"/>
    <dbReference type="GeneID" id="1099044"/>
    <dbReference type="KEGG" id="sco:SCO3608"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3666"/>
    <dbReference type="eggNOG" id="ENOG50335JA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117589_0_0_11"/>
    <dbReference type="OMA" id="AGWLTWK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="17093" checksum="69706DD5DF47ECD3" modified="1999-11-01" version="1">MAWFLGLGITGVVLLALSLVFDGLLEGVFDGVLDGVLEGWLSLPVVAGFVAMTGFGGAIALGSGWTGPAGAAGIGAVAGVGAGWLTYRFGRALMRDQTAVTPRTDDLLGTSGKVVTAIPADGYGEVLLRLAGQPLKCAARSTVPLARGAEVWVEAVPTGTSVVVRPVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z505</accession>
    <name>Q9Z505_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1960</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36033">
        <property type="entry name" value="T36033"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626224.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976859.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1960"/>
    <dbReference type="GeneID" id="1097394"/>
    <dbReference type="KEGG" id="sco:SCO1960"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1986"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_4_11"/>
    <dbReference type="InParanoid" id="Q9Z505"/>
    <dbReference type="OMA" id="ETWVYPG"/>
    <dbReference type="PhylomeDB" id="Q9Z505"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="23394" checksum="201A9E3C03FC38F0" modified="1999-05-01" version="1">MTYSGEVTVGGPADVHELKDLMITKVAVGPMNNNAYLLRCRATDEQLLIDAANDAHTLLGTIGDDGIASVVTTHRHGDHWQALAEVVAATGARTHAGRHDAEGIPVPTDVLIDDGDTIRVGQVELTARHIAGHTPGSVVLVYDDPHGHPHVFTGDCLFPGGVGNTFKDPDAFASLIHDVQTKVFDTLPDETWVYPGHGNDTTLGAERPHLPEWRARGW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5B5</accession>
    <name>HLDE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein HldE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">D-beta-D-heptose 7-phosphate kinase</fullName>
                <ecNumber evidence="1">2.7.1.167</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">D-beta-D-heptose 7-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">D-glycero-beta-D-manno-heptose-7-phosphate kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">D-beta-D-heptose 1-phosphate adenylyltransferase</fullName>
                <ecNumber evidence="1">2.7.7.70</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">hldE</name>
        <name type="synonym">rfaE</name>
        <name type="ordered locus">SCO6187</name>
        <name type="ORF">SC2G5.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="ChEBI" id="CHEBI:60208"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.167"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.167" evidence="1"/>
    <dbReference type="EC" id="2.7.7.70" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34841">
        <property type="entry name" value="T34841"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z5B5"/>
    <dbReference type="SMR" id="Q9Z5B5"/>
    <dbReference type="STRING" id="100226.SCO6187"/>
    <dbReference type="GeneID" id="1101628"/>
    <dbReference type="KEGG" id="sco:SCO6187"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6297"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021150_1_0_11"/>
    <dbReference type="InParanoid" id="Q9Z5B5"/>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="PhylomeDB" id="Q9Z5B5"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00437"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033785">
        <property type="term" value="F:heptose 7-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01603">
        <property type="entry name" value="HldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023030">
        <property type="entry name" value="Bifunc_HldE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000080128" description="Bifunctional protein HldE">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribokinase">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cytidylyltransferase">
        <location>
            <begin position="331"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01603"/>
        </source>
    </evidence>
    <sequence length="463" mass="47193" checksum="07AEB034625A1B0D" modified="1999-05-01" version="1">MTGPMAVRTDRTPLVVVGDALLDRDLTGTADRLAPDAPVPVVQECAERIRPGGAALAAYLAARDGREVTLIAGVGEDPAGLALRELLAPWLKLIPLPLTGTVPEKTRVLAQDRPVVRLDRGGGRVREATDEARDALGCARAVLVSDYGRGAADALRDVLAARPPLVWDPHPRGGPPVPGTRLVTPAEKEAHGFAPSEGRPGGGLRAAALNAAALVRDWRVAAVTVTLGSRGALLSYGEHPLLVPAPAAHHGDSCGAGDRFAATAAGLLADGALVGEAVEGAVGAATAFVAAGGAAAVPPAGSERALAALPDTDDPGALAARIRAEHGTVVAAGGCFDLLHAGHVGLLQAARRLGDCLVVCVNSDASVRRGKGGGRPVNPLADRVRVLRALACVDAVAVFDEDTPERLLGELRPDVWVKGGDYAGADLPEAGLLKEWGGQAVLLPYLDGRSSTALLARAAEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBJ9</accession>
    <name>Q9ZBJ9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6475</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35962">
        <property type="entry name" value="T35962"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630558.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030948.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6475"/>
    <dbReference type="GeneID" id="1101914"/>
    <dbReference type="KEGG" id="sco:SCO6475"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6575"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_21_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBJ9"/>
    <dbReference type="OMA" id="EAMYAES"/>
    <dbReference type="PhylomeDB" id="Q9ZBJ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="196"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="2">
        <location>
            <begin position="322"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="1">
        <location>
            <begin position="502"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="601" mass="62855" checksum="61BEE1F421103B54" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZC09</accession>
    <name>Q9ZC09_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6504</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34734">
        <property type="entry name" value="T34734"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030971.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6504"/>
    <dbReference type="GeneID" id="1101943"/>
    <dbReference type="KEGG" id="sco:SCO6504"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6606"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042786_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZC09"/>
    <dbReference type="OMA" id="YYPKGLF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="138"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="376" mass="41250" checksum="27C4AC27135544CC" modified="1999-05-01" version="1">MSDSLGSAASTAGKAAKKNPLADVAQSEAADRLKAEVQDYLAAQATRLLTGVGTKLGETTGKLNDIAEGNSPGFAKLALDGGRKLAEGKSPMRAAFEVGAGKVKDNVVGAFKNLTGGKGRKKGGGGQKPTVIIEYVDVGVPLRTAYDQWTQYQDFSTFAKGVKSANRADDTSSDWQLKVLWSNRSWKATTTEQVPDDRISWTSEGAKGSTKGVVSFHELAANLTRVVLVIEYYPKGLFEKTGNIWRAQGRRARLDLKNYVRHITFKGEADDGWRGEIRDGEVVRSHEDAVAEEEEERQAEQEPEQEPEQEPEGEYDEEAEGEPEEEYEEAAESEYAEPEEDEAPEEDKEAGEDEYASGDEDEDEYEYEDAEGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O69856</accession>
    <name>O69856_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6026</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34706">
        <property type="entry name" value="T34706"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630137.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030602.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6026"/>
    <dbReference type="GeneID" id="1101467"/>
    <dbReference type="KEGG" id="sco:SCO6026"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6126"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_16_2_11"/>
    <dbReference type="InParanoid" id="O69856"/>
    <dbReference type="OMA" id="TGAGWPF"/>
    <dbReference type="PhylomeDB" id="O69856"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016509">
        <property type="term" value="F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="340"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="524"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAA19238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="709" mass="75287" checksum="364A2385C7ED89B4" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O69861</accession>
    <name>DCUP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="1">UPD</shortName>
            <shortName evidence="1">URO-D</shortName>
            <ecNumber evidence="1">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemE</name>
        <name type="ordered locus">SCO6031</name>
        <name type="ORF">SC1C3.19</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34711">
        <property type="entry name" value="T34711"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630142.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972892.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O69861"/>
    <dbReference type="SMR" id="O69861"/>
    <dbReference type="STRING" id="100226.SCO6031"/>
    <dbReference type="PRIDE" id="O69861"/>
    <dbReference type="GeneID" id="1101472"/>
    <dbReference type="KEGG" id="sco:SCO6031"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6131"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_1_11"/>
    <dbReference type="InParanoid" id="O69861"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="PhylomeDB" id="O69861"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187648" description="Uroporphyrinogen decarboxylase">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <sequence length="355" mass="38169" checksum="4A5AE1BECA60C9B7" modified="1998-08-01" version="1">MSANQSPAGQPPTATYDSAFLKACRREPVPHTPVWFMRQAGRSLPEYLKVREGIPMLESCMRPELVAEITLQPVRRHGVDAAVYFSDIVVPLKAIGIDLDIKPGVGPVIAEPIRTRADLARLRDLTPEDVAYVTEAFGLLTRELGATPLIGFAGAPFTLASYLVEGGPSRNHEHTKALMYGDPQLWADLLDRLAGITAAFLKVQIEAGASAVQLFDSWVGALSPADYRRSVLPASRKVFEAVSGYGVPRIHFGVGTGELLGLLGEAGADVVGVDWRVPLDEAARRVGPGKALQGNLDPAVLFAGREAVETKTREVLDAATGLEGHVFNLGHGVLPTTDPDALTRLVEYVHTQTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>O86496</accession>
    <name>O86496_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6328</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34642">
        <property type="entry name" value="T34642"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630421.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030829.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6328"/>
    <dbReference type="GeneID" id="1101769"/>
    <dbReference type="KEGG" id="sco:SCO6328"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6441"/>
    <dbReference type="HOGENOM" id="CLU_2275777_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="102" mass="10449" checksum="3DC7C469E31F20FE" modified="1998-11-01" version="1">MSDPAHVLARLGGSWTWLMASALATLVPGAPAGVLGLRNPLAVDVAGIVVLALPAESARALTRLLGLWLGLLGLTEAVVALGRRCVPHGTRPSTRVTPVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O87600</accession>
    <accession>Q7AKQ7</accession>
    <name>O87600_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative LacI family regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative LacI family repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1642</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5448" last="5453">
            <title>The 20S proteasome of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Nagy I."/>
                <person name="Tamura T."/>
                <person name="Vanderleyden J."/>
                <person name="Baumeister W."/>
                <person name="De Mot R."/>
            </authorList>
            <dbReference type="PubMed" id="9765579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="1999-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="De Mot R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">A3</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">A3</strain>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF086832">
        <property type="protein sequence ID" value="AAC64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625917.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977184.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1642"/>
    <dbReference type="GeneID" id="1097073"/>
    <dbReference type="KEGG" id="sco:SCO1642"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1657"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_11"/>
    <dbReference type="OMA" id="LGDKWRG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010133104" evidence="5">
        <location>
            <begin position="31"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB59495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="350" mass="36898" checksum="522AAFB6E85E1853" modified="1998-11-01" version="1">MSPVQQSRRKRRRTVARGSTRPTSRDVAQAAGVSQAAVSLVLGDKWRGRVSEPTAQRVRDAALELGYRPNLAARNLRLGRTRTVLLVVPALTTEFFAEVYTGAARVAAEHGFGVVLYPSPEGVGPARDPFASAQAALDGVIASSMAADALSAIRGDQLPLVMLDSDPEGSLGAATVNLDIADGIRQVTEHLLSLGHRGFLHLAADIPSWTFEVRARELASRLADAPGTELRTIRAPISIEGALRATEAALAAPGPRPTALVCDDDKLAAGAYKAIRRAGLRVPDDLSVTGLDDLGLATAIDPELTTVRLDAEAFGERGMRALLAVLEGRPPEKGDLPVSLVVRGSTAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O87836</accession>
    <name>O87836_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6581</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35769">
        <property type="entry name" value="T35769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630660.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972397.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6581"/>
    <dbReference type="GeneID" id="1102020"/>
    <dbReference type="KEGG" id="sco:SCO6581"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6686"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_11"/>
    <dbReference type="InParanoid" id="O87836"/>
    <dbReference type="OMA" id="AKWWQLA"/>
    <dbReference type="PhylomeDB" id="O87836"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="277"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA19774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="476" mass="51064" checksum="F68000FC8F4150BF" modified="1998-11-01" version="1">MGQGALARSFDARGAIDMTTTDVTRVAAYREVTDRNGRVYRVGESDIDLMGRKRKWMVILPWIGMMGISSAEYAFASAEDTLHEAQHWSSGSIYWMMTAWVFCQAAVAFPAGRLRESGKLPARWAMMLGSAGTLLGYLSLAFAPHVSLAFIGFGVFSGMGAGMVYATCVNMVGKWYPERRGGKTGFVNGGFAYGSVPFVFIFHGYMDTSNFRWVLVSAGVFLAAMVAIAGFYFRDPPKNWWPAAVDPLNPPADPRARRSLEKNPPAVKQYSPMEAWKTGRVALMWFCLACTSGVNIFGIAFQVDIGEEAGFAAGVVAAAMSLKAIVNGTGRGVIGWLSDLYGRKQCLLYVCAILGLAQFGIIWSAEIKNLPLFLVFSAISGFGGGAIFPMFAALTADYFGENNNATNYGMVYSSKLVSGLGAGMGSVVVGVWGYNGAFSLAGSISIFAGFVALSLRPPGRPKGKRVTPNPQPLGEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O87844</accession>
    <name>EFG2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor G 2</fullName>
            <shortName>EF-G 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fusB</name>
        <name type="ordered locus">SCO6589</name>
        <name type="ORF">SC8A6.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35777">
        <property type="entry name" value="T35777"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630668.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031026.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O87844"/>
    <dbReference type="SMR" id="O87844"/>
    <dbReference type="STRING" id="100226.SCO6589"/>
    <dbReference type="GeneID" id="1102028"/>
    <dbReference type="KEGG" id="sco:SCO6589"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6696"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_11"/>
    <dbReference type="InParanoid" id="O87844"/>
    <dbReference type="OMA" id="HKRGEVH"/>
    <dbReference type="PhylomeDB" id="O87844"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091228" description="Elongation factor G 2">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="686" mass="72921" checksum="BCFC581BFC9FAFC2" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O88012</accession>
    <name>O88012_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6656</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35155">
        <property type="entry name" value="T35155"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630731.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031081.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6656"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="GeneID" id="1102095"/>
    <dbReference type="KEGG" id="sco:SCO6656"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6762"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_11"/>
    <dbReference type="InParanoid" id="O88012"/>
    <dbReference type="OMA" id="FAEPRVY"/>
    <dbReference type="PhylomeDB" id="O88012"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="409" mass="43786" checksum="6AA1F9AD35FDF2B2" modified="1998-11-01" version="1">MPPLRQEVEAGAAGLDPGALARLDLHFARQVDEGRLPGFLVAVARGGRVAHLTVHGLRDVAAGLPVTADTLWRIYSMTKPVTSVAVLTLVEEGRLALDDPVDRYLPAFAEPRVYVGGTGENVVTRPATGPVRVRHLMTHTAGLTFGFYRTHPVDALYRAAGVESSVRPGADLAETVDLYASLPLQFDPGTEWNYSVASNVLGRLVEVVSGQPLDVFCAERIFGPLGMTDTGFHVADAQAGRLAELYGETEDGGIAPVPGLPLLGRPRFLSGSGGLASSAYDVHRFAELLRRRGELDGVRLLAPATVDLMTRNHLPGDADLRSFGSRPAHDERGNDGVGFGLGVSVVTDPSRTRSPSGLGTYGWSGVATTTFWVDPGRDLTVQFMTQVRPRSSHAVYPDLKRLVHEALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O88067</accession>
    <name>O88067_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1610</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36845">
        <property type="entry name" value="T36845"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625886.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027881.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1610"/>
    <dbReference type="GeneID" id="1097041"/>
    <dbReference type="KEGG" id="sco:SCO1610"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1622"/>
    <dbReference type="eggNOG" id="ENOG50334N1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058606_1_0_11"/>
    <dbReference type="OMA" id="TPPPGWY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="32610" checksum="B4570904E2091034" modified="1998-11-01" version="1">MTPPPGWYRDPSAPHQERWWDGTAWTEHRRAPGPVGYGPAVGGTPVPGPGPGPEPGPGTGTGGRGKAVAVTAAAAVLVAAIVTGVFVLGEDDDGSPRTRTPPVTETATAPAPGNDPASSSPTASEPSADDPALVEDQLNGITLPLPDGWVRPEHVAEDDVMMTTDGTYDCPADGSVCRHGLVVSRTVTANAESSPKVLAQQDIEDAADDAYDRDLIGNKPFGGIESHEEVASGPVAVAGRAGYYVRWRVTTAEGPGGYVQSMVFPSTVGTESPILVRYVFDAGEDGPPLADMDTITKGIRPIGDADTGGGVGSGIGPTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-08-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>P27903</accession>
    <name>DPO3B_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Beta sliding clamp</fullName>
            <shortName>Beta clamp</shortName>
            <shortName>Sliding clamp</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-clamp processivity factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA polymerase III beta sliding clamp subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA polymerase III subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dnaN</name>
        <name type="ordered locus">SCO3878</name>
        <name type="ORF">SCH18.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Bacteriol." volume="174" first="3220" last="3226">
            <title>Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome.</title>
            <authorList>
                <person name="Calcutt M.J."/>
                <person name="Schmidt F.J."/>
            </authorList>
            <dbReference type="PubMed" id="1577691"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AF187159">
        <property type="protein sequence ID" value="AAA26735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B41870">
        <property type="entry name" value="B41870"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628065.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975054.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P27903"/>
    <dbReference type="SMR" id="P27903"/>
    <dbReference type="STRING" id="100226.SCO3878"/>
    <dbReference type="GeneID" id="1099314"/>
    <dbReference type="KEGG" id="sco:SCO3878"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3951"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_1_1_11"/>
    <dbReference type="InParanoid" id="P27903"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="PhylomeDB" id="P27903"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000105471" description="Beta sliding clamp">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="376" mass="39956" checksum="F11C285D703EF567" modified="1992-08-01" version="1">MKIRVERDVLAEAVAWAARSLPARPPAPVLAGLLLKAEEGQLSLSSFDYEVSARVSVEAEIEEEGTVLVSGRLLADISRALPNRPVEISTDGVRATVVCGSSRFTLHTLPVEEYPALPQMPEATGTVPGEVFASAVQQVAIAAGRDDTLPVLTGVRIEIEGDSVTLASTDRYRFAVREFLWKPENPDISAVALVPAKTLQDTAKALTSGDQVILALSGSGAGEGLIGFEGAGRRTTTRLLEGDLPKYKTLFPTEFNSVAVIETAPFVEAVKRVALVAERNTPVRLSFEQGVLILEAGSSDDAQAVERVDAQLEGDDISIAFNPTFLLDGLSAIDSPVAQLSFTTSTKPALLSGRPAVDAEADEAYKYLIMPVRLSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>P35925</accession>
    <name>Y3875_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>UPF0232 protein SCO3875</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3875</name>
        <name type="ORF">SCH18.12c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Gene" volume="151" first="23" last="28">
            <title>Gene organization in the dnaA-gyrA region of the Streptomyces coelicolor chromosome.</title>
            <authorList>
                <person name="Calcutt M.J."/>
            </authorList>
            <dbReference type="PubMed" id="7828880"/>
            <dbReference type="DOI" id="10.1016/0378-1119(94)90628-9"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0232 family.</text>
    </comment>
    <dbReference type="EMBL" id="L27063">
        <property type="protein sequence ID" value="AAA65214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB92995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T10968">
        <property type="entry name" value="T10968"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628062.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975057.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P35925"/>
    <dbReference type="STRING" id="100226.SCO3875"/>
    <dbReference type="GeneID" id="1099311"/>
    <dbReference type="KEGG" id="sco:SCO3875"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3948"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087206_0_2_11"/>
    <dbReference type="InParanoid" id="P35925"/>
    <dbReference type="OMA" id="RWPQIVG"/>
    <dbReference type="PhylomeDB" id="P35925"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00630">
        <property type="entry name" value="UPF0232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023007">
        <property type="entry name" value="UPF0232_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211367" description="UPF0232 protein SCO3875">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="190" mass="19772" checksum="5173D4FC781E7076" modified="1994-06-01" version="1">MSADAPEPGPGQSPGERASGGPEPSGVDLARVALRAAREAARARGDAAQQKKQARRGGLRSGARADGRDPMALGSAINRLITERGWETPAAVGGVMGRWPEIVGADVAKHCVPERYDEDERVLVVRCDSTAWATNLRLLAPTLVARLNEDLGHGSVRMIKVLGPGGPGGPGRRYGPLRAPGSQGPGDTYG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q06539</accession>
    <accession>Q9RKJ7</accession>
    <name>VDH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Valine dehydrogenase</fullName>
            <shortName>ValDH</shortName>
            <ecNumber evidence="3">1.4.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">vdh</name>
        <name type="ordered locus">SCO4089</name>
        <name type="ORF">SCD25.25c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="J. Bacteriol." volume="175" first="4176" last="4185">
            <title>Sequence, transcriptional, and functional analyses of the valine (branched-chain amino acid) dehydrogenase gene of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Tang L."/>
                <person name="Hutchinson C.R."/>
            </authorList>
            <dbReference type="PubMed" id="8320231"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 2-21</scope>
        <source>
            <strain>A3(2) / J802</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="J. Gen. Microbiol." volume="136" first="273" last="281">
            <title>Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Navarette R.M."/>
                <person name="Vara J.A."/>
                <person name="Hutchinson C.R."/>
            </authorList>
            <dbReference type="PubMed" id="2324704"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Oxidative deamination of branched-chain amino acids. Oxidizes L-valine and L-alpha-aminobutyric acid efficiently, and L-isoleucine and L-leucine less efficiently. Does not act on D-valine. The catabolism of L-valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors. Uses NAD; no activity was found with NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30763"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.23"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text>Repressed in minimal medium by the presence of glucose and NH4(+), glycerol and NH4(+), or glycerol and asparagine.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <phDependence>
            <text evidence="3">Optimum pH is 10.5 with valine as substrate.</text>
        </phDependence>
    </comment>
    <comment type="pathway">
        <text>Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text>By valine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.23" evidence="3"/>
    <dbReference type="EMBL" id="L13455">
        <property type="protein sequence ID" value="AAA71983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B40657">
        <property type="entry name" value="B40657"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628270.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029424.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q06539"/>
    <dbReference type="SMR" id="Q06539"/>
    <dbReference type="STRING" id="100226.SCO4089"/>
    <dbReference type="GeneID" id="1099526"/>
    <dbReference type="KEGG" id="sco:SCO4089"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4148"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_0_0_11"/>
    <dbReference type="InParanoid" id="Q06539"/>
    <dbReference type="OMA" id="TYVADMD"/>
    <dbReference type="PhylomeDB" id="Q06539"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-17657"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043837">
        <property type="term" value="F:valine dehydrogenase (NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000182813" description="Valine dehydrogenase">
        <location>
            <begin position="2"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AA sequence." evidence="5" ref="1">
        <original>Q</original>
        <variation>A</variation>
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA71983." evidence="5" ref="1">
        <original>A</original>
        <variation>V</variation>
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="2324704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="8320231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="364" mass="38309" checksum="80E8432B9FF645B4" modified="2007-01-23" version="4">MTDVNGAPADVLHTLFHSDQGGHEQVVLCQDRASGLKAVIALHSTALGPALGGTRFYPYASEAEAVADALNLARGMSYKNAMAGLDHGGGKAVIIGDPEQIKSEELLLAYGRFVASLGGRYVTACDVGTYVADMDVVARECRWTTGRSPENGGAGDSSVLTSFGVYQGMRAAAQHLWGDPTLRDRTVGIAGVGKVGHHLVEHLLAEGAHVVVTDVRKDVVRGITERHPSVVAVADTDALIRVENLDIYAPCALGGALNDDTVPVLTAKVVCGAANNQLAHPGVEKDLADRGILYAPDYVVNAGGVIQVADELHGFDFDRCKAKASKIYDTTLAIFARAKEDGIPPAAAADRIAEQRMAEARPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q53873</accession>
    <name>Q53873_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO4733</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35562">
        <property type="entry name" value="T35562"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628891.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029829.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4733"/>
    <dbReference type="GeneID" id="1100174"/>
    <dbReference type="KEGG" id="sco:SCO4733"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4804"/>
    <dbReference type="eggNOG" id="ENOG5033U55">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642370_0_0_11"/>
    <dbReference type="InParanoid" id="Q53873"/>
    <dbReference type="OMA" id="AMFCTES"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA20389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="411" mass="42826" checksum="CD93509E751508B3" modified="1999-05-01" version="2">MGPAGPSVPCMRTGKSDISGWLVRPAGRHPWAVLATVLAASAAHAARTTSDGGMDNAIVVRAARTWLAGGSPYDDPHFLYLPSAVLAAVPQALLPGAVLRVLVPCAVTVLLALAWACALRLHRVPLGSRLAVLGLTGLALGFAPFGHLVRLGNWTVTATVALPLALLLASRGRWTGAGVVIGAAVALKPLLAPVVLLFLFAGRWRALAAAVLVPALASAAAALAMPDPAGFFTRTLPFLLHGEDGFVRLYEASPAAVLPRLGVPPALAQGLAVAAASAGVLCAYRRWRRADPGPLRLAETGAGLMLSAFLVSRPSYDHYLLVALPLLLAGLPYAGSVARGAWFWIALVPQVPGLTWPWLEGERRRAFRDAFTLCVLAVTVARQARTGPAGADDRVPQGRSPEPERAPAAPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-05-25" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>Q59833</accession>
    <accession>Q9L1K4</accession>
    <name>GLGB1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>1,4-alpha-glucan branching enzyme GlgB 1</fullName>
            <ecNumber>2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Alpha-(1-&gt;4)-glucan branching enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycogen branching enzyme 1</fullName>
            <shortName>BE 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">glgB1</name>
        <name type="synonym">glgBI</name>
        <name type="ordered locus">SCO5440</name>
        <name type="ORF">SC6A11.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Microbiol." volume="18" first="89" last="99">
            <title>Tissue-specific glycogen branching isoenzymes in a multicellular prokaryote, Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bruton C.J."/>
                <person name="Plaskitt K.A."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="8596463"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1995.mmi_18010089.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="1998-03" db="EMBL/GenBank/DDBJ databases">
            <title>Duplicated gene clusters reveal a possible 'carbon relay' during aerial mycelium development in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Schneider D."/>
                <person name="Bruton C.J."/>
                <person name="Chater K.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18"/>
    <dbReference type="EMBL" id="X83397">
        <property type="protein sequence ID" value="CAA58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB72416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ001205">
        <property type="protein sequence ID" value="CAA04603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S70079">
        <property type="entry name" value="S70079"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629578.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030247.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q59833"/>
    <dbReference type="SMR" id="Q59833"/>
    <dbReference type="STRING" id="100226.SCO5440"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1100880"/>
    <dbReference type="KEGG" id="sco:SCO5440"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5521"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004245_3_2_11"/>
    <dbReference type="InParanoid" id="Q59833"/>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="PhylomeDB" id="Q59833"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000188749" description="1,4-alpha-glucan branching enzyme GlgB 1">
        <location>
            <begin position="1"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA58314/CAA04603." evidence="3" ref="1">
        <original>T</original>
        <variation>R</variation>
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA58314." evidence="3" ref="1">
        <original>GTAARRASG</original>
        <variation>WHGRPASIRLTLPPLATVWLRPA</variation>
        <location>
            <begin position="766"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="774" mass="85451" checksum="1D55555330F249BF" modified="2003-08-15" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKE3</accession>
    <name>Q7AKE3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6834</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630905.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031219.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6834"/>
    <dbReference type="GeneID" id="1102273"/>
    <dbReference type="KEGG" id="sco:SCO6834"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6944"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_11"/>
    <dbReference type="InParanoid" id="Q7AKE3"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="PhylomeDB" id="Q7AKE3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB71847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="326" mass="34591" checksum="7D0B5E6CF96715DD" modified="2012-05-16" version="1">MSTAKDVRDVIVIGSGPAGYTAALYTARASLNPLVFGGAIFVGGSLTTTTEVENFPGFPDGVQGPELMENMRAQAERFGAEMVDDDIVAVDLTGDVKTVTDTAGTVHRARTVIVATGSGYRKLGVPKEDELSGRGVSWCATCDGFFFRDRDIVVVGGGDTAMEEATFLTRFARSVTVVHRRSALRASQVMQNRAFSEDKISLAFDSEVATLHEENGMLSGMTLRDTLTGETRELATTGLFIAIGHDPRTELFKGQLHLDSEGYLMVESPSTRTNVPGVFGAGDVVDHTYRQAITAASSGCAAALDAERYLAARSDTSVSAEVVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJY9</accession>
    <name>Q8CJY9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2658</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAD55198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733579.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028490.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2658"/>
    <dbReference type="GeneID" id="1098092"/>
    <dbReference type="KEGG" id="sco:SCO2658"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2705"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_11"/>
    <dbReference type="InParanoid" id="Q8CJY9"/>
    <dbReference type="OMA" id="QNAAWEL"/>
    <dbReference type="PhylomeDB" id="Q8CJY9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176133" evidence="1">
        <location>
            <begin position="30"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="445" mass="48299" checksum="5E13BEE912700666" modified="2003-03-01" version="1">MPGISRKAALAVAASASLALLATACTGQSATGASDDPNAETTITFWHGWSAPAEVKAVQANVDRFEKAHPNIKVKVVGNINDDKLNQALRAGGSSGPDVVSSFTTSNIGKFCSSGAFLDLKPFVEKSKLDLDALIPKPMLDYTQFEGTRCALPLLGDAYGLYYNKDAFEAAGIKAPPKTWSEFAQVAKKLTKTKGDGYRQLGFMPNYHGYETVVDHYMSQWDHAYFDEDGRSAVAEDPAFAEMFTYQKKLVDDLGGFEKLEKYRNTFGDEWGAKHPFQTGQVAMQLDGEWRLGMAKDAGVDFEIGTAPMPVADDEAAEYGKGFLSGTVMGIAPQSKKQNAAWELVKYMTTDTGAVVAFANAIRNVPSTFPALKSPDLKTDPEFKTFLDIAQHRESNSPPASVNGATYQLTLQDLGYQYESGKVKDLKAGLEKAAAQIDRDIEQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK05</accession>
    <name>Q8CK05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2164</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAD55296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35280">
        <property type="entry name" value="T35280"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733561.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976652.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2164"/>
    <dbReference type="GeneID" id="1097597"/>
    <dbReference type="KEGG" id="sco:SCO2164"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2200"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_11"/>
    <dbReference type="InParanoid" id="Q8CK05"/>
    <dbReference type="OMA" id="WRGVRTD"/>
    <dbReference type="PhylomeDB" id="Q8CK05"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
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        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
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        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
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        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="846"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1041" mass="108053" checksum="864F634EF7E06CF7" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK56</accession>
    <name>Q8CK56_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0480</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAD55443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733503.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0480"/>
    <dbReference type="GeneID" id="1095903"/>
    <dbReference type="KEGG" id="sco:SCO0480"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.459"/>
    <dbReference type="eggNOG" id="COG4188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309501_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="22108" checksum="322D5582F574DF98" modified="2003-03-01" version="1">MQGNGRSFPGLRSTGPPDLPTSRPPGLPASGPTTPGDPGRGAGLLQEVPQEIPARQGRPVRRFPVAPVMTESGRPRVPTGSAMRPSTRSRSMDNRSSSSGVARPPAAYGTSPTMVLLYRPGAAWTADPYVLSPGRRSPLTLFAAEHFLGGISGYEAAETTDENPAAHVAVVRRVPLAHLRHTLGVDSTDWTAARRTLAGTAHPLGRLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IU3</accession>
    <name>Q93IU3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BldKA, putative ABC transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5112</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629262.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973865.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5112"/>
    <dbReference type="TCDB" id="3.A.1.5.36">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100553"/>
    <dbReference type="KEGG" id="sco:SCO5112"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5195"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_11"/>
    <dbReference type="InParanoid" id="Q93IU3"/>
    <dbReference type="OMA" id="SPGQLMW"/>
    <dbReference type="PhylomeDB" id="Q93IU3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="128"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC44319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="37471" checksum="84A78EA92D3599C6" modified="2001-12-01" version="1">MTSPIEIEGAEASSVLDKESAPQGDAPKPKEPEGRKPGQLMWARFKRDRAGVISAFVVLFFFVIAAAAPLISMVYGKDPYTLYGQDNPDLLDMFTMPAAPYGGIDGDFWFGIEPGLGRDVFTQLLYGMRNSMATALAATIIMTVLGVLIGLAGGYFGGKIDYWLGRITDFFMALPSQLFFVAAMPVITTVFVAPDKETPTYVRAAAIIIVLSFLGWMSMARIVRGATMSLRDREFIEAARISGASPWRILRKELLPNIVTPTLVQATLTLPSTILSIAFLSFVGVGYVEPTPDWGRMFAIGADIVEQDPYYMLFPGVAMVIFIVAFNLLGDSVRDAFDPKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IW8</accession>
    <name>Q93IW8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1302</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625588.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027706.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1302"/>
    <dbReference type="GeneID" id="1096725"/>
    <dbReference type="KEGG" id="sco:SCO1302"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1304"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_2_1_11"/>
    <dbReference type="InParanoid" id="Q93IW8"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="PhylomeDB" id="Q93IW8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
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        <property type="entry name" value="Impact_bac/arc"/>
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        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IMPACT_YIGZ"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC42849.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="208" mass="22244" checksum="8EBE627309215527" modified="2001-12-01" version="1">MQDEYRTVARAGVHETEINRSRFLCSLAPAATEQDAQAFVAGVRKEHADATHNCWAYVIGADAGVQKASDDGEPGGTAGVPMLQMLLRRDMRYVVAVVTRYYGGVKLGAGGLIRAYGGAVGEALDDLGTLTRRRFRLATVTVDHHRAGKLQNDLRTAGRAVRDVRYAEAVTIEVGLPEADVDTFRSWLADATAGSAGFELGGEAYGDA</sequence>
</entry>
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    <accession>Q93IZ9</accession>
    <name>Q93IZ9_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative secreted peptidase</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7521</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC42148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SMR" id="Q93IZ9"/>
    <dbReference type="STRING" id="100226.SCO7521"/>
    <dbReference type="GeneID" id="1102959"/>
    <dbReference type="KEGG" id="sco:SCO7521"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7635"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_2_3_11"/>
    <dbReference type="InParanoid" id="Q93IZ9"/>
    <dbReference type="OMA" id="FIDMSAS"/>
    <dbReference type="PhylomeDB" id="Q93IZ9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176569" evidence="1">
        <location>
            <begin position="27"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="371" mass="39201" checksum="5A54095CBFCD8C27" modified="2001-12-01" version="1">MHRKRLAAAVLLAAALTGALAPVAAAHPGRPGHPGAVQRQLDLLTARDGVPGALAYDGRTTRTSGVADLESGRAMTGERGRFRLASDTKAFTATAVLRLVADGRLGLGDRAGSYVPQLADSPLTVRQLLKQTSGLPEYSALVDWTRPGTPEEYLALALDAEPVFEPGTDWGYSNTNYLVLGMVIDEVSGVGFRTYVERTILRPLHLDDTYWPAPGELDLRGPHARNYGVHPAHPQDGRVDVTELPGYEFGASGGLVSTPVDLNAFWDGLFGGRLLPGWAVRLMTRDTTDIGGRDVYPAGSRYGYGVASIPLSCGGVYWGHGGDLPGGSVGGGRATGGRGTVTVYTTTWAAEGDSLRHLQGTVDAALCAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J45</accession>
    <name>Q93J45_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2009-08" db="PDB data bank">
            <title>Crystal structure of Sco3058 with bound inhibitor L-Ala-L-Asp Phosphinodipeptide.</title>
            <authorList>
                <person name="Nguyen T.T."/>
                <person name="Cummings J.A."/>
                <person name="Tsai C.-L."/>
                <person name="Barondeau D.P."/>
                <person name="Raushel F.M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <reference evidence="3 5 6" key="3">
        <citation type="journal article" date="2010" name="Biochemistry" volume="49" first="611" last="622">
            <title>Structure, mechanism, and substrate profile for Sco3058: the closest bacterial homologue to human renal dipeptidase .</title>
            <authorList>
                <person name="Cummings J.A."/>
                <person name="Nguyen T.T."/>
                <person name="Fedorov A.A."/>
                <person name="Kolb P."/>
                <person name="Xu C."/>
                <person name="Fedorov E.V."/>
                <person name="Shoichet B.K."/>
                <person name="Barondeau D.P."/>
                <person name="Almo S.C."/>
                <person name="Raushel F.M."/>
            </authorList>
            <dbReference type="PubMed" id="20000809"/>
            <dbReference type="DOI" id="10.1021/bi901935y"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2011-05" db="PDB data bank">
            <title>Crystal structure of dipeptidase from Streptomyces coelicolor complexed with phosphinate pseudodipeptide L-Leu-D-Ala.</title>
            <authorList>
                <person name="Fedorov A.A."/>
                <person name="Fedorov E.V."/>
                <person name="Cummings J."/>
                <person name="Raushel F.M."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <reference evidence="8" key="5">
        <citation type="submission" date="2011-05" db="PDB data bank">
            <title>Crystal structure of dipeptidase from Streptomyces coelicolor complexed with phosphinate pseudodipeptide L-Leu-D-Glu.</title>
            <authorList>
                <person name="Fedorov A.A."/>
                <person name="Fedorov E.V."/>
                <person name="Cummings J."/>
                <person name="Raushel F.M."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <reference evidence="9" key="6">
        <citation type="submission" date="2011-05" db="PDB data bank">
            <title>Crystal structure of dipeptidase from Streptomyces coelicolor complexed with phosphinate pseudodipeptide L-Phe-D-Asp.</title>
            <authorList>
                <person name="Fedorov A.A."/>
                <person name="Fedorov E.V."/>
                <person name="Cummings J."/>
                <person name="Raushel F.M."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <reference evidence="10" key="7">
        <citation type="submission" date="2011-05" db="PDB data bank">
            <title>Crystal structure of dipeptidase from Streptomyces coelicolor complexed with phosphinate pseudodipeptide L-Tyr-D-Asp.</title>
            <authorList>
                <person name="Fedorov A.A."/>
                <person name="Fedorov E.V."/>
                <person name="Cummings J."/>
                <person name="Raushel F.M."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627279.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028742.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="PDB" id="3ID7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.30 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3ISI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="X=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3ITC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3K5X">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3S2J">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.30 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3S2L">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3S2M">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDB" id="3S2N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=1-400"/>
    </dbReference>
    <dbReference type="PDBsum" id="3ID7"/>
    <dbReference type="PDBsum" id="3ISI"/>
    <dbReference type="PDBsum" id="3ITC"/>
    <dbReference type="PDBsum" id="3K5X"/>
    <dbReference type="PDBsum" id="3S2J"/>
    <dbReference type="PDBsum" id="3S2L"/>
    <dbReference type="PDBsum" id="3S2M"/>
    <dbReference type="PDBsum" id="3S2N"/>
    <dbReference type="SMR" id="Q93J45"/>
    <dbReference type="STRING" id="100226.SCO3058"/>
    <dbReference type="GeneID" id="1098491"/>
    <dbReference type="KEGG" id="sco:SCO3058"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3118"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_4_2_11"/>
    <dbReference type="InParanoid" id="Q93J45"/>
    <dbReference type="OMA" id="CDHPRNI"/>
    <dbReference type="PhylomeDB" id="Q93J45"/>
    <dbReference type="EvolutionaryTrace" id="Q93J45"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3 4 5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4 5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4 5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4 5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4 5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3ID7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3ISI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3ITC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3K5X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3S2J"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="3S2L"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="3S2M"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="3S2N"/>
        </source>
    </evidence>
    <sequence length="400" mass="43253" checksum="52E262E7928E72BA" modified="2001-12-01" version="1">MTSLEKARELLREFPVVDGHNDLPWALREQVRYDLDARDIAADQSAHLHTDLARLRSGGVGAQYWSVYVRSDLPGAVTATLEQIDCVRRLIDRHPGELRAALTAADMEAARAEGRIASLMGAEGGHSIDNSLATLRALYALGVRYMTLTHNDNNAWADSATDEPGVGGLSAFGREVVREMNREGMLVDLSHVAATTMRDALDTSTAPVIFSHSSSRAVCDHPRNIPDDVLERLSANGGMAMVTFVPKFVLQAAVDWTAEADDNMRAHGFHHLDSSPEAMKVHAAFEERVPRPVATVSTVADHLDHMREVAGVDHLGIGGDYDGTPFTPDGLGDVSGYPNLIAELLDRGWSQSDLAKLTWKNAVRVLDAAEDVSRGLRAARGPSNATIEQLDGTAAEQPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J60</accession>
    <name>Q93J60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0984</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625280.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027493.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0984"/>
    <dbReference type="GeneID" id="1096407"/>
    <dbReference type="KEGG" id="sco:SCO0984"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.982"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_11"/>
    <dbReference type="InParanoid" id="Q93J60"/>
    <dbReference type="OMA" id="SVMEVFY"/>
    <dbReference type="PhylomeDB" id="Q93J60"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="190"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="289" mass="30255" checksum="2A4BD1832EA55A68" modified="2001-12-01" version="1">MSGGIRRVGVVGGGRMGAGIAEVCARAGLDTVVCEADTVAARAARDRVAASLDRAVRRGTLTQAAARDTLARMVFTGSLEDLADRQLVVEAVAENLDAKTEIFAALDKIVEDPAAVLASNTSSLPVMRLGMATGRADRVVGLHFFNPVPVLPLVEVVASLHTSAATAAAAEDFATGTLGKTVIRSQDRAGFVVNALLVPYLLSAIRMAESGFAIAADIDIGMELGCAHPMGPLKLADLIGLDTVASIAESLYDEFKEPLYAPPPLLQRMVEAGLLGRKTGRGFHTYDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JI9</accession>
    <name>Q93JI9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1972</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626235.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976847.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1972"/>
    <dbReference type="GeneID" id="1097406"/>
    <dbReference type="KEGG" id="sco:SCO1972"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1998"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_11"/>
    <dbReference type="InParanoid" id="Q93JI9"/>
    <dbReference type="OMA" id="ANVACWA"/>
    <dbReference type="PhylomeDB" id="Q93JI9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="9"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="30976" checksum="E710A2E424C7637F" modified="2001-12-01" version="1">MSLAPGGALLVVGDVVTDIVARHRGPLAPGTDTAAAVRRLPGGAGANVACWAAHEGCGDVRLLGRVGTDASAWHERELTACGVRPLLVVDSAAPTGTVICLVDTADSAERTFLTDSGAALRIGPGDWSDTLLDGVGRLHLSGYLLFSEPGRALVSVALAAARARGVPVSLDPASAGFLTELGVDRFLGLVEGVDVLLPSRDEACLLTGLPDVADAAAKLSRHVPLVIVKQGAKGALVARSGTVGARVAAVTAAPRDSTGAGDAFTGAFLAALLAGAEAEEATAAGCRAGARAVERVGGRPPRAAGRGPGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RT3</accession>
    <name>Q93RT3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6308</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630405.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030815.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6308"/>
    <dbReference type="GeneID" id="1101749"/>
    <dbReference type="KEGG" id="sco:SCO6308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6422"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_0_11"/>
    <dbReference type="InParanoid" id="Q93RT3"/>
    <dbReference type="OMA" id="AGNGMHW"/>
    <dbReference type="PhylomeDB" id="Q93RT3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="333" mass="36060" checksum="932F36EC6B2EA9CB" modified="2001-12-01" version="1">MSVKPEAASALFAGPFALATLSAPEGAAFPALVTPDARVTDLRSAFEDTGLSMRGLLDDWDAVAPRLAALAVDDAAARRPLAEFRVHAPVEPRQVFQSGANYRQHVIDLHVAHRAPDDDRPEEERRAEAAEIMDRRAAEDLPYVFIGLPSAVTGPYDDVVLPAWAEKPDWELELAAVIGRPAHRVSVEEALDHVAGYTIANDLTDRATVFRRDMPQIGTDWLRSKNAPGFTPLGPWIVPAASIANPGDLRLTLRLNGETMQDESTKDMIFNVARMVSHVSQTARLLPGDLVLTGSPAGNGMHWGRLLRDGDVMDASITGLGAQRTRCVAEAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RW2</accession>
    <name>ECTA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>L-2,4-diaminobutyric acid acetyltransferase</fullName>
            <shortName>DABA acetyltransferase</shortName>
            <ecNumber>2.3.1.178</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ectA</name>
        <name type="ordered locus">SCO1864</name>
        <name type="ORF">SCI39.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16901"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58761"/>
            <dbReference type="ChEBI" id="CHEBI:58929"/>
            <dbReference type="EC" id="2.3.1.178"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amine and polyamine biosynthesis; ectoine biosynthesis; L-ectoine from L-aspartate 4-semialdehyde: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. EctA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.178"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626131.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976956.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93RW2"/>
    <dbReference type="SMR" id="Q93RW2"/>
    <dbReference type="STRING" id="100226.SCO1864"/>
    <dbReference type="GeneID" id="1097298"/>
    <dbReference type="KEGG" id="sco:SCO1864"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1889"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111896_0_0_11"/>
    <dbReference type="InParanoid" id="Q93RW2"/>
    <dbReference type="OMA" id="DGAAIWR"/>
    <dbReference type="PhylomeDB" id="Q93RW2"/>
    <dbReference type="UniPathway" id="UPA00067">
        <property type="reaction ID" value="UER00122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033816">
        <property type="term" value="F:diaminobutyrate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019491">
        <property type="term" value="P:ectoine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012772">
        <property type="entry name" value="Ectoine_EctA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02406">
        <property type="entry name" value="ectoine_EctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000220092" description="L-2,4-diaminobutyric acid acetyltransferase">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="170" mass="18534" checksum="7A599BD6DC328B51" modified="2001-12-01" version="1">MTAAQADLQIDRPRVADGAALWRIARDSEVLDLNSSYSYLLWCRDFAATSAVVRDGHGVPVGFITGYVRPDSPDTLLVWQVAVDGTYRGRGLAATLVDGLADRVARERGITILETTISPDNTASQRLFTSFAERRGARLEREVLFDTAVFPDGPHEPEVLYRIGPLSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q05</accession>
    <name>Q99Q05_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.281</name>
        <name evidence="1" type="ordered locus">SCP1.72c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="17510" last="17515">
            <title>2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining.</title>
            <authorList>
                <person name="Corre C."/>
                <person name="Song L."/>
                <person name="O'Rourke S."/>
                <person name="Chater K.F."/>
                <person name="Challis G.L."/>
            </authorList>
            <dbReference type="PubMed" id="18988741"/>
            <dbReference type="DOI" id="10.1073/pnas.0805530105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639647.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639891.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039373.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095151"/>
    <dbReference type="GeneID" id="1095364"/>
    <dbReference type="KEGG" id="sco:SCP1.281"/>
    <dbReference type="KEGG" id="sco:SCP1.72c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8021"/>
    <dbReference type="HOGENOM" id="CLU_1250016_0_0_11"/>
    <dbReference type="OMA" id="MTEVRHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="24602" checksum="E09B5D8AE5BF5D53" modified="2001-06-01" version="1">MRGPVTQLEVEALRSLYTASLHLRQEYAAAVNRTLTHYRLGDIAEDNARGKAFTHHHDVLRQMASAADRYERDVGMLAWSHAGAAVRLGTRVLERLVHGQAPLGVDEVAALCDEPTLGELRTTLSTPADTLLPHRDPWIKEHQEKSRKQLLQAVEGVFSDAAQLDSRDKPLPDDVVAGFRLTQVSPPDMDPLYEGRLEQLLSYAEGLPHEISVHLKHTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADE1</accession>
    <name>Q9ADE1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5066</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629217.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030032.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5066"/>
    <dbReference type="GeneID" id="1100507"/>
    <dbReference type="KEGG" id="sco:SCO5066"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5145"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056519_1_1_11"/>
    <dbReference type="InParanoid" id="Q9ADE1"/>
    <dbReference type="OMA" id="GMQTAVN"/>
    <dbReference type="PhylomeDB" id="Q9ADE1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="59"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="304" mass="33599" checksum="14B45C278F6BD860" modified="2001-06-01" version="1">MDTITLGDVTVTRVREYYGPVGMTPEAFVPDSPAQAWDTHRSWLVPDFLDAETRIVNTAIQTWVLRSEGRTILVDTGVGNHKDRPYAPVWSRLETDFLANLARAGVQPEDVDIVINTHLHIDHVGWNTYLDGRTWVPTFPNATYLMAKADFDYWNPANEIKTLLGRGNQNVFEDSVAPVHEAGLTRLWEDGHRIDSNLRLELAPGHTPGSSVLRLESGSDRGLFVGDLMHSPIQIHEPDANSCFCEDPAEARATRRRLLGSAVDSNALVFPAHLGGHGAAEVVREGGKFAVKGWAPFTPYTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADK5</accession>
    <name>Q9ADK5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629107.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029974.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4955"/>
    <dbReference type="GeneID" id="1100396"/>
    <dbReference type="KEGG" id="sco:SCO4955"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5035"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676020_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADK5"/>
    <dbReference type="OMA" id="VRTEREC"/>
    <dbReference type="PhylomeDB" id="Q9ADK5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323109" evidence="2">
        <location>
            <begin position="19"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="395" mass="41831" checksum="33CDE347688877E5" modified="2001-06-01" version="1">MGLALAGAGLATVGTAPAAAGSYDCPSGYFCGWTGESANGSMWKTNKSVADLGGWDNKIRSYVNRTTSVACVYEDKNYTPWGGYWAQEPNSPGEYNGDPVATTSSVKFVRTERECSQPAYPSWSSETSPKALGFGDLNGDRRADVVTRDEAGRLWFSPGDTTGRLIGTGGWNAMSALTRHGDFSRDGREDLIAREASTGKLWLYPGTGTGSLGSRKLIGKSGWNAMNRVTAFGDLTGDGRSDLIAVEKATARLWLYPGTSTGTLGARKLIGKSGWNAMNALIGMGDVTGDGRPDLYAREASTGKLWLYPGTSTGTLGSRTLVGTGGWNAMAHFLPVGDFSGDGVPDLATVTNEKYVLDGYPGNLGWLVTYRGRGNGFLTSGVPTHGEWWGLNGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADP5</accession>
    <name>Q9ADP5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4010</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628192.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029380.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4010"/>
    <dbReference type="GeneID" id="1099446"/>
    <dbReference type="KEGG" id="sco:SCO4010"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4073"/>
    <dbReference type="eggNOG" id="ENOG50333FU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121949_1_0_11"/>
    <dbReference type="OMA" id="CTMQYGG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176616" evidence="3">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="4">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="15867" checksum="CD9077A0AA8B4024" modified="2001-06-01" version="1">MFQVTRTPAARLLGAAALSAAALASVCAAPSAAVAGAGPAAPEGDHLTVTVRDAGAGMDGTYELYCHPVGGDHPDTEGACAVVDRDTRWGQEVFAPAPEGAVCTMQYGGPATARVTGTWAGRPVDATYDRRDGCEISRWDRMVPLLPEVGGPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK02</accession>
    <name>Q9AK02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7726</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631764.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031861.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7726"/>
    <dbReference type="GeneID" id="1103164"/>
    <dbReference type="KEGG" id="sco:SCO7726"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7848"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_1_0_11"/>
    <dbReference type="InParanoid" id="Q9AK02"/>
    <dbReference type="OMA" id="CVAMPAI"/>
    <dbReference type="PhylomeDB" id="Q9AK02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="23390" checksum="C728C474D2AD00A2" modified="2001-06-01" version="1">MSTGDKAVLGALLTPEESVLALIDHQPFQVANLHSHEPTMVINNAVGLAKAAKVFEVPTILTTVLEERGGLILPGLQEVFPEQKPINRTFINTWQDERVVDAVKATGRKKLIIAGLWTEICVAMPAIQAVGEGFEVFVVTDASGGVSREAHDMAVQRMIQAGVVPITWMAVLGEWQRDWAREKTVAGVAEVQAQHGGASGVAFAWEMQLLATTAGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK72</accession>
    <name>Q9AK72_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4045</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628227.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029402.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4045"/>
    <dbReference type="TCDB" id="9.B.36.1.2">
        <property type="family name" value="the acid resistance membrane protein (hded) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1099481"/>
    <dbReference type="KEGG" id="sco:SCO4045"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4108"/>
    <dbReference type="eggNOG" id="COG3247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091585_4_0_11"/>
    <dbReference type="InParanoid" id="Q9AK72"/>
    <dbReference type="OMA" id="GIGWLFR"/>
    <dbReference type="PhylomeDB" id="Q9AK72"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="23753" checksum="CF9F67C25DD9D952" modified="2001-06-01" version="1">MTEPPSGSPGGTPYDDRGVHARHGTTHGPASGPQEPEPAFEGPLHLLSRAAWQTVLFTGIASLILGVLVLVWPGASLLAAGVLFGLYLVISGVLQLAAAFGTHRRTSLRVLAFISGAVSILLGLFCFRGPLQSVLLLALWIGIGWLFRGVTQIVAAAHDPTMPARGWQIFLGAVTVVAGIVLIDSPVESATVLMLVGGWWLVVVGVVEIVTSVRLRGRAHQVPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWG2</accession>
    <name>Q9EWG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative marR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4961</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629113.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974015.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4961"/>
    <dbReference type="GeneID" id="1100402"/>
    <dbReference type="KEGG" id="sco:SCO4961"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5041"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_15_0_11"/>
    <dbReference type="InParanoid" id="Q9EWG2"/>
    <dbReference type="OMA" id="PMGVKAL"/>
    <dbReference type="PhylomeDB" id="Q9EWG2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="166" mass="17855" checksum="C49847735525394E" modified="2001-03-01" version="1">MDMTTAGDTGLLETLQHEVALFARRAEQTRLGGVGQVRNSMDRAAYLLLNRLDKEGPMGVKALAASMGIDSSTVTRQVAPLVDTGLVKRTSHPEDGRAVVLQLSPRGVARLEEVRSSRRQLMAELTHDWAPQERETFCALLARFNGALSARMAPSGVSPTDAPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWI5</accession>
    <name>Q9EWI5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7599</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631641.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031770.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7599"/>
    <dbReference type="GeneID" id="1103037"/>
    <dbReference type="KEGG" id="sco:SCO7599"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7714"/>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055769_0_1_11"/>
    <dbReference type="InParanoid" id="Q9EWI5"/>
    <dbReference type="OMA" id="QDLEHAP"/>
    <dbReference type="PhylomeDB" id="Q9EWI5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="147"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="32600" checksum="C791678048748173" modified="2001-03-01" version="1">MVRQSSSRAPEPSAQDAPLADVLTRVRAARPSLAPSERRVADAVLADPGQVAELSIHALAERASTSAATVMRFCRTIGTGNYPQLRLALAAAAAREHALGGERAAQGGTDISPTDSLDRIVSKIIYNEVRALEDSGAALDVDALGRAVDAVAKARRVDIFGVGASAFVGQDLHQKLHRIGRMAFIWSDRHAALTATALLGPGDVALAVSHSGETEDTTEPLQAAAERGATTIALTNDPGSTLATGADLVLTTCARETPFRSGATVSRIAQLAVIDCLFVGVAQRSYDAATTALEETYGAVQRRRRPTRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWJ8</accession>
    <name>Q9EWJ8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ordered locus">SCO1441</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC17559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625722.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977384.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9EWJ8"/>
    <dbReference type="STRING" id="100226.SCO1441"/>
    <dbReference type="GeneID" id="1096867"/>
    <dbReference type="KEGG" id="sco:SCO1441"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1451"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_1_2_11"/>
    <dbReference type="InParanoid" id="Q9EWJ8"/>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="PhylomeDB" id="Q9EWJ8"/>
    <dbReference type="BRENDA" id="3.5.4.25">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="225"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="219"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAC17559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="46269" checksum="0C9D361865D0672F" modified="2001-03-01" version="1">MSTAPILYSPDGPEDLVLDPVEQAVADIAAGRPVVVVDDENRENEGDLVIAAEKATEEIVAFMMTECRGLICAPMEGEELDRLRLPQMVDDNTESMKTAFTVSVDAGAAHGVTTGISAADRATTLRLLAGGTAEPGDLVRPGHVFPLRARPGGVLVRNGHTEAAVDLARLAGLRPAGAIVEIAGEDGRMLRLPELIPFARKHGLTIISIEDLIAYRRSAEPTVRREAEVRLPTKHGEFTAYGYRSTVDGVEHIALVHGEIGDGEDVLVRVHSECLTGDVFGSQRCDCGPQLDASLDRIQAEGRGVVVYLRGHEGRGIGLMSKLRAYELQERGRDTLDANLELGLPADARDYGAGAQILADLGVRAVRLLTNNPDKSDALERHGITVTGREPMPVQAGEHNLRYLRTKRDRMGHDLPWLDTTPVSTCGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWU1</accession>
    <name>Q9EWU1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625034.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027319.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0730"/>
    <dbReference type="GeneID" id="1096153"/>
    <dbReference type="KEGG" id="sco:SCO0730"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.720"/>
    <dbReference type="eggNOG" id="COG3871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139738_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EWU1"/>
    <dbReference type="OMA" id="RYWYHAW"/>
    <dbReference type="PhylomeDB" id="Q9EWU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="153" mass="16603" checksum="CC6E96961FE59A93" modified="2001-03-01" version="1">MRRGRRRGPGAAGLDFRSMDDDASLARLGAGKYLLVTTYRKNGTPVATPVWVVRDGDALGVWTVSDSWKVKRVRNRADVLVGPCDVRGRPTGEQVPGTAEICDAATTARYRRLLARKYGVLGRLTLLGSRLRRGLDGTLGIRVTLTSAPPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX27</accession>
    <name>Q9EX27_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mut-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1013</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625309.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977815.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1013"/>
    <dbReference type="GeneID" id="1096436"/>
    <dbReference type="KEGG" id="sco:SCO1013"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1009"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_3_11"/>
    <dbReference type="InParanoid" id="Q9EX27"/>
    <dbReference type="OMA" id="GEQPAAC"/>
    <dbReference type="PhylomeDB" id="Q9EX27"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17538" checksum="AF954716F0CD8C9D" modified="2001-03-01" version="1">MATPDFIRDLRASAGHQLLWLPGVTAVVFDDEGRVLLGRRSDNGRWSLIGGIPEPGEQPAACAVREVEEETAVQCVVERLVLVQALKPVTYDNGDVCQFMDITFRCRAVGGEARVNDDESLEVGWFEVDALPDIKEFGQTRVKQALSDAPTWFEPTGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2L4</accession>
    <name>Q9F2L4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3767</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627957.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975175.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3767"/>
    <dbReference type="GeneID" id="1099203"/>
    <dbReference type="KEGG" id="sco:SCO3767"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3826"/>
    <dbReference type="eggNOG" id="COG3793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127140_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2L4"/>
    <dbReference type="OMA" id="RVCCAIG"/>
    <dbReference type="PhylomeDB" id="Q9F2L4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC10305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="16602" checksum="F3F54A0AD8FE8FA7" modified="2001-03-01" version="1">MALWDRFKESASQMQTQLVAKKNDLKSGAFRDASMAMCALVAAADGTVDASERQRVAQLISTNEVLQNFPADDLRRRFEENLDKLTADFAFGKVGILQEIAKAKKKPAEARAVVQIGIVIGGADGDFDKDERAVVREACYALDLPPHEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2T5</accession>
    <name>Q9F2T5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4627</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628789.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029776.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4627"/>
    <dbReference type="GeneID" id="1100067"/>
    <dbReference type="KEGG" id="sco:SCO4627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4700"/>
    <dbReference type="eggNOG" id="ENOG502ZTSU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171888_0_0_11"/>
    <dbReference type="OMA" id="ADFMEPT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046251">
        <property type="entry name" value="DUF6284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19801">
        <property type="entry name" value="DUF6284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="89" mass="9646" checksum="AEADD692834DAB38" modified="2001-03-01" version="1">MNLIVTAQDAVTAFADFMEPTDAELDAIEQEMPVILAGVDLVDAQIIALDRTPNEMDNRRIRRARNRVLAARRELANRTAGASLPGGAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-10" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F316</accession>
    <name>CLPX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">SCO2617</name>
        <name type="ORF">SCC80.02c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAC09993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626853.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028457.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F316"/>
    <dbReference type="SMR" id="Q9F316"/>
    <dbReference type="STRING" id="100226.SCO2617"/>
    <dbReference type="GeneID" id="1098051"/>
    <dbReference type="KEGG" id="sco:SCO2617"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2663"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_11"/>
    <dbReference type="InParanoid" id="Q9F316"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="PhylomeDB" id="Q9F316"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000160430" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="428" mass="46781" checksum="0595BED69A60871D" modified="2001-03-01" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRWEELPKPREIYEFLESYVVGQEAAKKALSVAVYNHYKRVQAGENGGAQGREDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKIIEGRAGAKGIGFGAQIRSKREIESKDQFEQVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLQILVEPRNALVKQYERLFELDGVELDFERGALEAIADQAILRQTGARGLRAIMEEVLQGVMYEVPSRKDVARVVITADVVLSNVNPTLIPRDSRGRGPGEQKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F358</accession>
    <name>Q9F358_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2417</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAC12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626662.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028342.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2417"/>
    <dbReference type="GeneID" id="1097851"/>
    <dbReference type="KEGG" id="sco:SCO2417"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2458"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026704_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F358"/>
    <dbReference type="OMA" id="RWFDNYV"/>
    <dbReference type="PhylomeDB" id="Q9F358"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="351" mass="37357" checksum="3B1AB5DFF0DE5404" modified="2001-03-01" version="1">MKRPRGKPLFKPVKERNPVAVGVAGLLVLTLVALLVYNVDRLPFGGGTTYSADFSESAGLDEGDEVRIAGVKVGQVTGVALDGAKVKVSFEVEDAWIGDRTTAAIAIKTVLGDKYLALDPLGSGRQDPGARIPLARTTSPYDVTQAFQDLSGTVDDIDTGRLAESFETISDTFKDSPPHVRKAATGLSDLSKSISKRDAKLSELLKGSARFTKTLENNKSSFETLIEDGGPLLGELRDRRTAINALLKGSQDLGTELGGLVKDNEKQLGPTLKALGRVTSVLEKNNTRLGETLALVGPYYRLVGNTLGNGRWFDSYLCGVVPRDYLPETSQPSTGCLPPKQPAAAQGSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L1</accession>
    <name>Q9F3L1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5253</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629399.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973717.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5253"/>
    <dbReference type="GeneID" id="1100694"/>
    <dbReference type="KEGG" id="sco:SCO5253"/>
    <dbReference type="eggNOG" id="ENOG5031U52">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191575_0_0_11"/>
    <dbReference type="OMA" id="FVPVWGP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7738" checksum="7E13E733E1F84F6E" modified="2001-03-01" version="1">MDSDTYACPVCGQPVEAVVRRHKTLGIWVPEWAPGPCGNPKCEAGPGKNAGAAEAEARPGRPEHSRETVTENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBL6</accession>
    <name>Q9FBL6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5142</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973835.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5142"/>
    <dbReference type="GeneID" id="1100583"/>
    <dbReference type="KEGG" id="sco:SCO5142"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5225"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128227_1_1_11"/>
    <dbReference type="OMA" id="GYRMTEV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176692" evidence="3">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="12705" checksum="F32723B4D032CE9E" modified="2001-03-01" version="1">MVMFLFLVIALAVVVAAVTLAVVGGGESGPLPDAAPERVRDALPPDRPVGRGDVERLRFPLVVRGYRMADVDDALGRLGAELAEREARIADLESALAGARAAAAHRHVVMDKPDREEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBW2</accession>
    <name>Q9FBW2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7823</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971315.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7823"/>
    <dbReference type="GeneID" id="1103261"/>
    <dbReference type="KEGG" id="sco:SCO7823"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7933"/>
    <dbReference type="eggNOG" id="ENOG503327J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164714_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBW2"/>
    <dbReference type="OMA" id="CAHIAVD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025356">
        <property type="entry name" value="DUF4260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14079">
        <property type="entry name" value="DUF4260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC03641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="14521" checksum="AB6DFC30CBA9E193" modified="2001-03-01" version="1">MTPPTVQGPTRSSASGPVRGTWALFSAFLLFWLVLEMVNHGGGTIPLGIAGLFTPDLTLFVGPSGSHEAGQLPRGRVPGYNLVHRPVVPLLWLAVCVVLPDPPGTALFTFGIAWLLHIALDRALGYGLRTADGWQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-01-20" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBX1</accession>
    <name>Y7813_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative S-adenosyl-L-methionine-dependent methyltransferase SCO7813</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO7813</name>
        <name type="ORF">SC8E7.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631842.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031934.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FBX1"/>
    <dbReference type="SMR" id="Q9FBX1"/>
    <dbReference type="STRING" id="100226.SCO7813"/>
    <dbReference type="PRIDE" id="Q9FBX1"/>
    <dbReference type="GeneID" id="1103251"/>
    <dbReference type="KEGG" id="sco:SCO7813"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7923"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056160_2_0_11"/>
    <dbReference type="InParanoid" id="Q9FBX1"/>
    <dbReference type="OMA" id="GSAASMW"/>
    <dbReference type="PhylomeDB" id="Q9FBX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000361266" description="Putative S-adenosyl-L-methionine-dependent methyltransferase SCO7813">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="283" mass="30406" checksum="2FE602E7190BB46C" modified="2001-03-01" version="1">MTGEQEWVQPSGVWATAVGVARVRALESEREDALFRDPLAQAFAAAGGLWPSSPPLPDDEAARRRRLAVAFSIVVRTKFLDDLLEHATASGVRQVVLLGAGMDSRAFRMAWPEGTRLFEVDTPAPLEFKASVLRQERAVAHCERITVAVDLREDWPSALAAAGHDAAIPTAWIGEGLLIYLPEDAVELLLARIGEQSASGSRMGLTLGSRGVIERFAAGAVPGSAASMWVSEMPDDPVGWLAGHGWEASCHTLRERAVAYGRPMSTLPQHEDGPGGLISAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBZ5</accession>
    <name>Q9FBZ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7187</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631245.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031492.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7187"/>
    <dbReference type="TCDB" id="1.A.1.23.4">
        <property type="family name" value="the voltage-gated ion channel (vic) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1102625"/>
    <dbReference type="KEGG" id="sco:SCO7187"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7286"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012980_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FBZ5"/>
    <dbReference type="OMA" id="VPEMDRE"/>
    <dbReference type="PhylomeDB" id="Q9FBZ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044849">
        <property type="entry name" value="CASTOR/POLLUX/SYM8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010420">
        <property type="entry name" value="CASTOR/POLLUX/SYM8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31563">
        <property type="entry name" value="PTHR31563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06241">
        <property type="entry name" value="Castor_Poll_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Castor_Poll_mid" evidence="4">
        <location>
            <begin position="271"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC01587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="672" mass="71214" checksum="27D4C38882A46303" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCF3</accession>
    <name>Q9FCF3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628392.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029509.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4217"/>
    <dbReference type="GeneID" id="1099657"/>
    <dbReference type="KEGG" id="sco:SCO4217"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4280"/>
    <dbReference type="eggNOG" id="COG3217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_0_2_11"/>
    <dbReference type="InParanoid" id="Q9FCF3"/>
    <dbReference type="OMA" id="YPVKGCA"/>
    <dbReference type="PhylomeDB" id="Q9FCF3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="126"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="31158" checksum="03E3B1302F7A25B3" modified="2001-03-01" version="1">MANVVDLICYPVKGCAGASTSDALLTPAGLAHDRSFMVISENGIFRTQRRHPRLALIRPAIGTDGTRLTLDAAHGADGTGRFGTLCLDVTTSAPRRDVDLFGTAFQGIDQGDEAAAWLSEFLGAPSRLVRVPPEHNRITDGLTPGPSGYADSSAVHLLSRASLALLNQRLAERGAAILPMNRFRPNIVVDSHEDHDHDSGGDPAALPHAEDRARRISLGGTELGYAKLAVRCAVTLVEQETGARRGPEPLRTLAAYRRAASGGVVFGAKFSVITPGKLSVGDEVVIQEWGDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCG3</accession>
    <name>Q9FCG3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative AraC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4206</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628381.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029500.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4206"/>
    <dbReference type="GeneID" id="1099646"/>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.4270"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_16_11"/>
    <dbReference type="InParanoid" id="Q9FCG3"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AraC-bd"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
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    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
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    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
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    </dbReference>
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        <property type="entry name" value="HTH_ARAC"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="29783" checksum="A0930A7873081BE2" modified="2001-03-01" version="1">MGGRPKDQRNVSAWRPRVPGVVEVFHAHYTEYAYPMHVHDAWTLLIVDDGAVRYDLDRHEHGTPHDTVSLLPPHVPHNGSPATPDGFRKRVLYLDASRLGDELIGPAVDAPDLRDPVLRRRVGQLHAALALPGDELEAESRLTLIGDRLRDHLRPGTGAAGARRDPVLARRLRELLDERVVAGIGLTEAAALVPAHPAHLVRAFSGAYGIAPHQYLMSRRVDRARRLLLAGRAPADVAGATGFYDQAHLTRHFKRLVGVTPGRYRAGGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH6</accession>
    <name>Q9FCH6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4193</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628368.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029492.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4193"/>
    <dbReference type="GeneID" id="1099633"/>
    <dbReference type="KEGG" id="sco:SCO4193"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4257"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943057_0_0_11"/>
    <dbReference type="OMA" id="EFRAVHI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="333" mass="35807" checksum="9F3AA32923079535" modified="2001-03-01" version="1">MSEGGSSLSGRMAALRGRAETTLTKGLLLAVFFVGLVAQFVKPVGDALEGKTYIGGALLSIVGYVLYAEVLRLNAARDADGEQTRQLHEAVRRLSGEVQELTARLGPQSGDAATMERLIEECAQAVLRGGETQLSGMCFTGETFVEPLRRVLEDLPPDPSRSVSVRILVPDFTRPTGVPGLVRAADGKLTDAPGFRRHLTGKIAGYAQDLRTTRGRMLHKNQGTLSVEFRAVHISPFLKLYAIGDDVVYEGIYDTLEVRPDAYVTSAPLPQGPGPEEGQLLDLIGRGSLLTRWSRYDGEPGGVLVDRRCGFFGTLWDAARRLEPEAAPGGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M9</accession>
    <name>Q9K3M9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO1031</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625326.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027530.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1031"/>
    <dbReference type="GeneID" id="1096454"/>
    <dbReference type="KEGG" id="sco:SCO1031"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1026"/>
    <dbReference type="eggNOG" id="COG3127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K3M9"/>
    <dbReference type="OMA" id="IENDARG"/>
    <dbReference type="PhylomeDB" id="Q9K3M9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="812"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="303"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="496"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="755"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB96016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="855" mass="86735" checksum="50EAA5EC33BB4C95" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3W9</accession>
    <name>Q9K3W9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative marR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4375</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628544.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974608.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4375"/>
    <dbReference type="GeneID" id="1099815"/>
    <dbReference type="KEGG" id="sco:SCO4375"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4443"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_23_1_11"/>
    <dbReference type="InParanoid" id="Q9K3W9"/>
    <dbReference type="OMA" id="PGFLVWR"/>
    <dbReference type="PhylomeDB" id="Q9K3W9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="164" mass="18068" checksum="244067D79F05FEDB" modified="2000-10-01" version="1">MSKGSRHATPGFLVWRLANKWRVAVDRAVAPLGLTHAQYSVVASLYGMQRAGERPSQRRLADHTGLEALYVSKLARALEAAGLIERTRDPRDPRAVQLALTERGESVTREAITMVQELLQRMLEPLGGLDAARTRAFTDELTTLLDAPLAPPVPNDESTRRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C0</accession>
    <name>Q9K4C0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding protein, doubtful CDS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5391</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973605.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100831"/>
    <dbReference type="KEGG" id="sco:SCO5391"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5472"/>
    <dbReference type="eggNOG" id="ENOG5032YDP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133073_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4C0"/>
    <dbReference type="OMA" id="CWNAKDR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="12308" checksum="C1A184959E610914" modified="2000-10-01" version="1">MSPRRNRPKGAGSSGRSAEEDGSGRYGGWQSAENWQGEEWSVRHVAGASAQGKSYRCPGCDQLIPDGVPHVVAWPAHSGVDDRRHWHKACWNAKDRRTTRVQRSRNAPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4L4</accession>
    <name>Q9K4L4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7300</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631355.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971841.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7300"/>
    <dbReference type="GeneID" id="1102738"/>
    <dbReference type="KEGG" id="sco:SCO7300"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7402"/>
    <dbReference type="eggNOG" id="COG3642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035793_0_0_11"/>
    <dbReference type="OMA" id="EHRWYLS"/>
    <dbReference type="PhylomeDB" id="Q9K4L4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025111">
        <property type="entry name" value="DUF4032"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13224">
        <property type="entry name" value="DUF4032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4032" evidence="1">
        <location>
            <begin position="230"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="410" mass="46249" checksum="AAEA761D98D03166" modified="2000-10-01" version="1">MALQISATNPEHPALLLELPWQLPLEQWPEEYLVPLPRGISRHVVRYARAGDEVIAVKELAERPALREYQLLRDLDRLAIPAVDALAVVTGRLDAAGEALEPVLVTRHLGGSLPYRSMFETTLRPATMHRLMDALAVLLVRLHLAGFAWGDCSLSNTLFRRDAGAYAAYLVDAETGDLHPRLSDGQRDYDLDLARVNISGELLDLEASGALHPSVDPVEFGTEICARYRSLWQELTRTSVYPAGKYHYIERRIRRLNDLGFDVAEMQIEHASNGDTVSFVPKVVDAGHHQRQLLRLTGLDAEENQARRLLNDLESWMATQDDYAPGDPLGARPEVLAHRWVREVFRPTVRAVPVELRGAMDPAEIYHELLEHRWYLSERAQHDIGLDTAVEDYLVNILPRARETLQPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY42</accession>
    <name>Q9KY42_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2348</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626595.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976456.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2348"/>
    <dbReference type="GeneID" id="1097782"/>
    <dbReference type="KEGG" id="sco:SCO2348"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2386"/>
    <dbReference type="eggNOG" id="COG2356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043034_3_1_11"/>
    <dbReference type="InParanoid" id="Q9KY42"/>
    <dbReference type="OMA" id="RTAYRCT"/>
    <dbReference type="PhylomeDB" id="Q9KY42"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176755" evidence="1">
        <location>
            <begin position="34"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="23320" checksum="5CC669BDAD69600D" modified="2000-10-01" version="1">MPKFYARRRLGFLAAFTGLIASAGLLNGPAASAALPTPVSAATARTYLASLTVATEDRTGYDRDLFPHWITQSGTCNTRETILKRDGTNVVTDSSCAATSGSWYSPYDGATWSASSDVDIDHLVPLAEAWDSGADSWTTSRRQSFANDLTRPQLLAVTDNVNQSKGDQDPATWMPSRSAYRCTYVRAWVQVKYYYDLSVDSAEKSALQGYLANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY79</accession>
    <name>Q9KY79_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5023</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629175.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030010.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5023"/>
    <dbReference type="GeneID" id="1100464"/>
    <dbReference type="KEGG" id="sco:SCO5023"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5101"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816147_0_0_11"/>
    <dbReference type="OMA" id="YLEPIWE"/>
    <dbReference type="PhylomeDB" id="Q9KY79"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004328635" evidence="2">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="35701" checksum="21A74E97CE6CBCD5" modified="2000-10-01" version="1">MRCATVAAIVLVSVISAPMAFAGGRGEGGSRGSTDQQANADGNGTVSVTVGGVVFDRSKNGSGDSVGAVTSSTSWSPPACWYAPKYTPEELQDYLEPIWEAESTGYEWDAKQREKYNAKDEKKGFNKDKTGKGFWWGSYVNESFPPGWDKCDTDYFWVDTGDPPPADKENAVTPEVLAELAYAEIRVPGTEVTLAPAEATKVNLPTWAWLDGAEFKPVSVTASVKEIGIEATATAEPVSLQIKPGTPDAETYPASGVCEIKNGRIGAPYEKGRADDAPPCGVKYLRSSGDGTFPLQATVTWEIHWTGTGGAGGDLPDGTFGATQDVVVQEIQAVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYL0</accession>
    <name>Q9KYL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6931</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630997.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031313.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6931"/>
    <dbReference type="GeneID" id="1102369"/>
    <dbReference type="KEGG" id="sco:SCO6931"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7037"/>
    <dbReference type="HOGENOM" id="CLU_209221_0_0_11"/>
    <dbReference type="OMA" id="DDNCGST"/>
    <dbReference type="PhylomeDB" id="Q9KYL0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027575">
        <property type="entry name" value="LD_lanti_pre"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04363">
        <property type="entry name" value="LD_lanti_pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="59" mass="5773" checksum="3979667BD2184792" modified="2000-10-01" version="1">MNANTIKGQAHSPAATAGGDAFDLDISVLESDDGSATLINLTDDGCGSTCSSPCATNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYQ0</accession>
    <name>Q9KYQ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4482</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB92103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628647.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974468.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4482"/>
    <dbReference type="GeneID" id="1099922"/>
    <dbReference type="KEGG" id="sco:SCO4482"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4552"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9KYQ0"/>
    <dbReference type="OMA" id="WNGTVGM"/>
    <dbReference type="PhylomeDB" id="Q9KYQ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="286" mass="30653" checksum="7D566CDA4B928455" modified="2000-10-01" version="1">MDRLELRTLRYFAAVAEELHFGRAAVRLHMSQPPLSRAIRALEADLGATLFHRTSAGVTLTGAGAVLLDEARALLDRAARVPARVAAAAGAATLTVGILGDSTDPDVVRLADAYRRHHPHVEVTVRETDLTDPTCGLHAGLVDVALTRGPFDPTGLATRALRADPVGALLRADDPLAGRASLTPAELADRRWFRFPEGTDPLWQAYWNGGEPRPGPVVRTVRECQQVVLWNGTVGMTLADHVPADGLTVVPLTGLPPSPVVVAWPRTDPNPLIRSFVRLAVAVYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ08</accession>
    <name>Q9KZ08_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2229</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626480.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976585.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2229"/>
    <dbReference type="TCDB" id="3.A.1.1.44">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1097662"/>
    <dbReference type="KEGG" id="sco:SCO2229"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2266"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="InParanoid" id="Q9KZ08"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="PhylomeDB" id="Q9KZ08"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB90877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="33105" checksum="5690413EC2E52DD4" modified="2000-10-01" version="1">MSTSTAPTKAPAEQIAAPTAPPRKVRGRGERSRAASLASHGVLTLASLVALFPVAWLVYLSLGPDKNDYLHPGRIWSKMTFDNYAFVLQDTNFFDWLKSSLIVSLGTTVIGVLVAATTGYAVSRMRFPGYRKLMWVLLVTQMFPIAVLIVPMYQILSKLQLIDNYFGLILVYCSTAVPYCAWLLKGYFDTIPFEIDEAGRVDGLTPFGTFFRLILPLARPGLAVAGFYSFITAFGEVAFASTFMLSDTKYTFAVGLQSFVSEHDAQRNLMAATAVLVAIPVSAFFYLVQKNLVTGLTAGGTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ12</accession>
    <name>Q9KZ12_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2225</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626476.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976590.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KZ12"/>
    <dbReference type="STRING" id="100226.SCO2225"/>
    <dbReference type="GeneID" id="1097658"/>
    <dbReference type="KEGG" id="sco:SCO2225"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2262"/>
    <dbReference type="eggNOG" id="COG3232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139188_0_0_11"/>
    <dbReference type="OMA" id="MPQITVD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008704">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00580">
        <property type="entry name" value="CHMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004220">
        <property type="entry name" value="5-COMe_2-OHmuconate_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37950">
        <property type="entry name" value="PTHR37950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02962">
        <property type="entry name" value="CHMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB90873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="12970" checksum="54FEF917D2625531" modified="2000-10-01" version="1">MPQITVDYSGRLAGDFDRPGFARALHEAVVEIAAAKPPACKTQFRRTEDTVVGPDAEGHAVVHVTLGLLAGRTDETKVRLTEAVLELLRQYAKPGDGLALHASAEVRDLDPSYRKFETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ95</accession>
    <name>Q9KZ95_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4851</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629006.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974120.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4851"/>
    <dbReference type="GeneID" id="1100292"/>
    <dbReference type="KEGG" id="sco:SCO4851"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4929"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137436_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ95"/>
    <dbReference type="OMA" id="AWIVCLW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="17422" checksum="5AB3C411CFB44C2D" modified="2000-10-01" version="1">MAPAPGPTAGAPVRRLTVLYDAECSLCTHVRDWLLRQPRLVPLELVPAASEEARRRFPGLDHGATLDEVTAVGDAGQVYRGAAAWVVVLWALRGYRRLAHRLSTPKGALLARGAVLAAAKWRAGQRSAGGYAYRRADGWVYEPRLGWIYAGPGCDDGTCATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZJ4</accession>
    <name>Q9KZJ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625443.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977680.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1151"/>
    <dbReference type="GeneID" id="1096574"/>
    <dbReference type="KEGG" id="sco:SCO1151"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1149"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071993_0_0_11"/>
    <dbReference type="OMA" id="PGQEYLW"/>
    <dbReference type="PhylomeDB" id="Q9KZJ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="27718" checksum="E0C4CD2D2CA70E03" modified="2000-10-01" version="1">MMGPAHSLSGAAAWLGVGAATAAAGHPMPWPVLLAGALICAGAALAPDLDHKAATISRAFGPVSRGLCEIVDKLSYAVYKATKKRGDPRRTGGHRTLTHTWLWAVLIGGGTSVLAITGGRWAVLAILFVHMVLAIEGLLWRATRGSSSDVLVWLLAGTSAWILAGILDKPDGGADWLFTAPGQEYLWLGLPIVLGALVHDIGDALTVSGCPILWPIPVGRKRWYPIGPPKAMRFRAGSWVELKVLMPVFMLLGGVGGAAALNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZQ3</accession>
    <name>Q9KZQ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627126.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028653.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2900"/>
    <dbReference type="GeneID" id="1098333"/>
    <dbReference type="KEGG" id="sco:SCO2900"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2959"/>
    <dbReference type="eggNOG" id="ENOG50341VE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171866_0_0_11"/>
    <dbReference type="OMA" id="DHTLGRA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="12015" checksum="068C7CCD15D36501" modified="2000-10-01" version="1">MADTSDIRTPAQIEADIKRRREVLAETLDELGMRVHPKTIVDDAKAKVASSVDHTLGRAYVQVNRVVSDVKAQFVDETGAPRMERVVPVALVVAGVVGLLALGGTRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZV7</accession>
    <name>Q9KZV7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4144</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628321.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029462.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4144"/>
    <dbReference type="GeneID" id="1099584"/>
    <dbReference type="KEGG" id="sco:SCO4144"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4208"/>
    <dbReference type="eggNOG" id="COG5607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038934_0_0_11"/>
    <dbReference type="OMA" id="LHRYALE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="40457" checksum="685BE1537D052FF7" modified="2000-10-01" version="1">MGYLRAQATEFLRALRRHRESGPGTGTGTGTAAGANGALGEPGRAAQPGDDVDAARALRRAARRISGTLHTFQPLLDAGWAEEMRPELAWLSGTLALEHAYASRLERLLQALHRLSGSTAFPAPRPVGRAATATATTTSVPPAAPPTHPASANRGNLTVGAAKAGALLDRQLTLARTRAHSTALQALGSSRFHAVADKVALLASEVPLSSAGRRSATPAPGAAPVDLRPLATAARERLTDAVAALPLVTAGSPYNAEALVHGLSPDPAPHPQDTPWHQVRLLLRLHRYALEALAGADPRTDGTAGTDGTAGPPDDSVDVRLLAVGEALDRHRDASEAAAAAAQAARTPRIAPATAYALGVLHADQRHEVEAARYAFQHSWRKEPIRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L090</accession>
    <name>Q9L090_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2456</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028363.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2456"/>
    <dbReference type="GeneID" id="1097890"/>
    <dbReference type="KEGG" id="sco:SCO2456"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2498"/>
    <dbReference type="eggNOG" id="ENOG5033238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135044_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L090"/>
    <dbReference type="OMA" id="WVERNRN"/>
    <dbReference type="PhylomeDB" id="Q9L090"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB86121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="14928" checksum="999FDE822CFC7A55" modified="2000-10-01" version="1">MTEIFESAGQALLYGVVGLAVMAVGFGALDLVTPGKLFHVVWRDRNRGAAVLLGSQSVAVGLVIMSAIRASESEEGLGYGLFSTLLYGLAGVLVMTLVGIVIGLLTPGQMGAVALDDGDDHRPHPAAWVQAGMYLGTAAMVGAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0B1</accession>
    <name>Q9L0B1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2435</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626678.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028350.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2435"/>
    <dbReference type="GeneID" id="1097869"/>
    <dbReference type="KEGG" id="sco:SCO2435"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2476"/>
    <dbReference type="HOGENOM" id="CLU_104213_0_0_11"/>
    <dbReference type="OMA" id="CHEVWHM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB86100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="175" mass="19071" checksum="A1FE72B7FD8655B0" modified="2000-10-01" version="1">MRTRKEMRRLADALIDPIEVAVPADPEVLFEALVASVSAWRGREVVVHRAAFPPHTASGLWLERESHDDVVVDERAAVWHQIVILCHEVWHMSRRRAEGGAGADGRSRAVAARSDFSLAEEQEADRFGMLMGSRLRTWLDASTDSVFAAEGGGPASPESLAGRIGAALNYRGTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0G8</accession>
    <name>Q9L0G8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4789</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628947.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974183.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4789"/>
    <dbReference type="GeneID" id="1100230"/>
    <dbReference type="KEGG" id="sco:SCO4789"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4863"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524247_0_0_11"/>
    <dbReference type="OMA" id="NDLPYLM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB82028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="171" mass="18294" checksum="B816060066B2CE75" modified="2000-10-01" version="1">MRTDVHISPGSGGDWRDHAARYALLPLRIFLGVTFVYAGLDKLTDSAFMKDSGAGSVGDMMRTVRDSSAVPALVDLALKNPPGFGYAIALGELAVGIGTLLGLLTRLAALGGALISLSLWLTVSWASDPYYYGNDLAYLMAWLPLVLAGAPLLSLDALLRSRHRRRTGGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0X3</accession>
    <name>Q9L0X3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3731</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627922.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975209.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3731"/>
    <dbReference type="GeneID" id="1099167"/>
    <dbReference type="KEGG" id="sco:SCO3731"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3791"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_11"/>
    <dbReference type="InParanoid" id="Q9L0X3"/>
    <dbReference type="OMA" id="AHFRQIQ"/>
    <dbReference type="PhylomeDB" id="Q9L0X3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="7190" checksum="AC250D387045B432" modified="2000-10-01" version="1">MASGTVKWFNAEKGFGFIEQDGGGPDVFAHYSNINAQGFRELLEGQKVTFDIAQGQKGPTAENITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1F6</accession>
    <name>Q9L1F6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5449</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030253.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5449"/>
    <dbReference type="GeneID" id="1100889"/>
    <dbReference type="KEGG" id="sco:SCO5449"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5533"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="OMA" id="RMDANFR"/>
    <dbReference type="PhylomeDB" id="Q9L1F6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="323"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB76003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="605" mass="63161" checksum="D4E778458EB7740A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1T8</accession>
    <name>Q9L1T8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2957</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627181.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028681.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2957"/>
    <dbReference type="GeneID" id="1098390"/>
    <dbReference type="KEGG" id="sco:SCO2957"/>
    <dbReference type="HOGENOM" id="CLU_1414432_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="19652" checksum="C7ACFE12E7BE4B4C" modified="2000-10-01" version="1">MDRTRARAVMRGAGRARYGRTASPGPRADRQPAPPTTPRRVPADRPSADRPPTGEAPVTPGGRWPVGWGVPWGAVACGAPGRVGGRVSSGPRFREATGVLGARCSVLGARCSVLGGRWSVLGARCSVPGGRSGGVCRGAPWRPGRRAVSVVACRRACGSGRLRVSSVLGARCSVLGARCSVLGARCPVPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Z2</accession>
    <name>Q9L1Z2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">SCO2643</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626879.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028475.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L1Z2"/>
    <dbReference type="STRING" id="100226.SCO2643"/>
    <dbReference type="MEROPS" id="M01.009"/>
    <dbReference type="GeneID" id="1098077"/>
    <dbReference type="KEGG" id="sco:SCO2643"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2689"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007335_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L1Z2"/>
    <dbReference type="OMA" id="CAYTNTG"/>
    <dbReference type="PhylomeDB" id="Q9L1Z2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="230"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="535"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAB71818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="857" mass="94380" checksum="537DBAE3593655CE" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2D9</accession>
    <name>Q9L2D9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2480</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626722.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2480"/>
    <dbReference type="GeneID" id="1097914"/>
    <dbReference type="KEGG" id="sco:SCO2480"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2522"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_5_1_11"/>
    <dbReference type="InParanoid" id="Q9L2D9"/>
    <dbReference type="OMA" id="NLAGWYE"/>
    <dbReference type="PhylomeDB" id="Q9L2D9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="21373" checksum="7450EFE1A27DCFC4" modified="2000-10-01" version="1">MRRVKDTAIAAVTAVALCSGGWLLLGGSRPDAPPQPSAAQSGTTDRAGHADRGAAAPALPPSPPDRVRIPAIGVDAPLTGLGLTGTGSLDVPPAEKKNLAGWYEAGTTPGETGTAIVAGHVDNAEGPAVFYRLGALEKGSAIEIDRRDGGVAVFTVDAVEVYAADAFPDEKVYGAADRPELRVITCGGPYSRSTGYQGNVVVFAHLTGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2J1</accession>
    <name>Q9L2J1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0718</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625023.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978144.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0718"/>
    <dbReference type="GeneID" id="1096141"/>
    <dbReference type="KEGG" id="sco:SCO0718"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.706"/>
    <dbReference type="eggNOG" id="ENOG5030VX7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203318_0_0_11"/>
    <dbReference type="OMA" id="ENLEWAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB69690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7837" checksum="D6D91B31C469F80D" modified="2000-10-01" version="1">MSTSQPDASRPSEARAGDDRATPDDLLHTRTGTDVSPEDLVLAAGRDVTPQNLEWARRKLADEGPAALDKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCX7</accession>
    <name>Q9RCX7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0933</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977927.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0933"/>
    <dbReference type="GeneID" id="1096356"/>
    <dbReference type="KEGG" id="sco:SCO0933"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.928"/>
    <dbReference type="eggNOG" id="ENOG5033YH1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097171_0_1_11"/>
    <dbReference type="OMA" id="TIPRHES"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176858" evidence="1">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="17456" checksum="683DB1B5F2AF0BF3" modified="2000-05-01" version="1">MRAIPVASVALLGAAALSACVPAGAVGSNTFGFTVSPATVAPGGQVTLGVGRTEAGCRGRVTVTSPVFDTVTIPRHESSATARVDRDARRGAVYRVTFACRDKTGTVDLTIAGGGSHHPTDEPWRDKGVHAGQGGSVAGFDLKQIGFGAALIAGAVGTAYHLSRRRSGEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD99</accession>
    <name>Q9RD99_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627081.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028620.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2852"/>
    <dbReference type="GeneID" id="1098286"/>
    <dbReference type="KEGG" id="sco:SCO2852"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2912"/>
    <dbReference type="eggNOG" id="ENOG502ZEJI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155931_0_0_11"/>
    <dbReference type="OMA" id="ISARCVP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004332968" evidence="2">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="11723" checksum="1CAA465A269E2637" modified="2000-05-01" version="1">MYERGEQPMTRERSVPRPLLVLLLVLLPVALVDVGSLSATVALAATAAVGSALAVCAVIAARCAPAVPRTRVRTAIRDRDLRTAFLPQRDPDAPGRRRPRAPGHALPATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDQ1</accession>
    <name>Q9RDQ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2383</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626629.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028318.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2383"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1097817"/>
    <dbReference type="KEGG" id="sco:SCO2383"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2424"/>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245169_0_0_11"/>
    <dbReference type="OMA" id="QDYWSPG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="4">
        <location>
            <begin position="384"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB62715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1545" mass="161520" checksum="81EF325143593AEA" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ04</accession>
    <name>Q9RJ04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0161</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36943">
        <property type="entry name" value="T36943"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624497.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0161"/>
    <dbReference type="GeneID" id="1095585"/>
    <dbReference type="KEGG" id="sco:SCO0161"/>
    <dbReference type="HOGENOM" id="CLU_2119665_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="114" mass="12266" checksum="8519EC425DD496E8" modified="2000-05-01" version="1">MLRRSSVASVLYARRSGDPVTVLSARDFIRHLHCSSSVRSAGRAGQAAHRYRLAQPCGTFGAHEPRAGYECGPTACGGLRSGSLRWRTDGASAPLEEGARNGVDSRARRARTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB2</accession>
    <name>Q9RJB2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gas vesicle synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0652</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624961.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978210.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0652"/>
    <dbReference type="GeneID" id="1096075"/>
    <dbReference type="KEGG" id="sco:SCO0652"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.636"/>
    <dbReference type="HOGENOM" id="CLU_162460_1_0_11"/>
    <dbReference type="OMA" id="TAWIADH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="92" mass="10095" checksum="062B7DED92D49FFB" modified="2000-05-01" version="1">MGIVSGLLLLPLAPVRGTAWIADHLLQEARRQAHDPRAVQARLAALNRALDDGAIDEAAFEREEERLLTLLERPAGSTGPTTPTNQARRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJE3</accession>
    <name>Q9RJE3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0749</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978112.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0749"/>
    <dbReference type="GeneID" id="1096172"/>
    <dbReference type="KEGG" id="sco:SCO0749"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.739"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_11"/>
    <dbReference type="InParanoid" id="Q9RJE3"/>
    <dbReference type="OMA" id="MHIDNIP"/>
    <dbReference type="PhylomeDB" id="Q9RJE3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="35372" checksum="D138B960A2FE986F" modified="2000-05-01" version="1">MNILVTGAAGFIGSRYVRGLLASDAPGAPRVTVLDALTYAGSTANLELGHPRLEFVHGDIRDAALVDRLTAGADQVVHFAAESHVDRSIHAASDFVLTNVVGTQNLLDAALRHGVGPFVHVSTDEVYGSVDAGSATEEHPLRPSSPYSASKASGDLLALSYHRTHGLDVRVTRCSNNYGPHQFPEKLVPLFVTRLLDGHRVPLYGDGRNVRDWLHVDDHCRGVDLVRTRGRAGEVYNIGGGTELSNRDLTGLLLDACGAGPDRIVHVEDRKGHDLRYSVDWSKAREELGYRPHRDLATGLAETVAWYRDNRAWWEPLERRADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJL2</accession>
    <name>Q9RJL2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0376</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624698.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027066.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095799"/>
    <dbReference type="KEGG" id="sco:SCO0376"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.352"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RJL2"/>
    <dbReference type="OMA" id="EWLVVLS"/>
    <dbReference type="PhylomeDB" id="Q9RJL2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="22342" checksum="56D13994F700D7DA" modified="2000-05-01" version="1">MLLMTQEDGDLDSLVRKRIRALRVAQGWSLEELAGRARLSQSSLSRIENGRRRLALDQLVTLARALDTTLDQLVETADEDVITSPMIDSAHGLMRWPVKGDPGMTVVRQRMTQPPPENPARMRAHPGREWLVVLSGTAVLMLGHRRFRVETHQAAEFPTMMPHAIGTAGGPCEILGIFDRDARRGHQREGGEPEARDRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKE5</accession>
    <name>Q9RKE5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3493</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627694.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029029.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3493"/>
    <dbReference type="GeneID" id="1098929"/>
    <dbReference type="KEGG" id="sco:SCO3493"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3551"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_6_11"/>
    <dbReference type="InParanoid" id="Q9RKE5"/>
    <dbReference type="OMA" id="VYLEDHW"/>
    <dbReference type="PhylomeDB" id="Q9RKE5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:peptide-serine-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017198">
        <property type="term" value="P:N-terminal peptidyl-serine acetylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="22103" checksum="5AF478C7C6CCA432" modified="2000-05-01" version="1">MSRRPVTLHRIVFTDWLAVHSWAGLPDACRFQPWGPNTEEQTRDFVRAAAEAWTHIRPRRLAHVARVGNAVVGMGDLHVRSHTQRQGEISYIVHPRVWGQGIGTEIGRSLLSLGFDRWGLHRIRATCDPRNQASSRVLTKLGMTYEGRHRHTAWIRDGWRDSLVFSIIEDEWHEATRSGADAVAEGLPPRRPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKR1</accession>
    <name>Q9RKR1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2267</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50576">
        <property type="entry name" value="T50576"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626515.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028236.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2267"/>
    <dbReference type="GeneID" id="1097700"/>
    <dbReference type="KEGG" id="sco:SCO2267"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2304"/>
    <dbReference type="eggNOG" id="COG5398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057050_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RKR1"/>
    <dbReference type="OMA" id="KKSHTMA"/>
    <dbReference type="PhylomeDB" id="Q9RKR1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23993" checksum="72FCFCDEC2716311" modified="2000-05-01" version="1">MDSFSTLIRTASHQQHVEAETSTFMSDLLGGGLGVDAYARYTEQLWFVYEALEAAAGRLAADPVAGPFVRPELLRLASLERDLAHLRGADWRTGLTALPATEAYAARVRECAEEWPAGYVAHHYTRYLGDLSGGQIIRDKAERTWGFARKGDGVRFYVFEEISNPAAFKREYRDLLDGIRADDLEKQRVVAECKRAFALNTAVFRALGEEFPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKW0</accession>
    <name>Q9RKW0_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6216</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6216"/>
    <dbReference type="DNASU" id="1101657"/>
    <dbReference type="GeneID" id="1101657"/>
    <dbReference type="KEGG" id="sco:SCO6216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6330"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_4_2_11"/>
    <dbReference type="InParanoid" id="Q9RKW0"/>
    <dbReference type="OMA" id="VRGYETD"/>
    <dbReference type="PhylomeDB" id="Q9RKW0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="15473" checksum="94F4AE1789B9E7EE" modified="2000-05-01" version="1">MSEPFSVPVTVRGYETDTQGHLNQSVYLNYAEHARWSLLQAAGIRQADLVARGVGPVALETTIRFQRELLAGDEVTVTCAFEWGTGKTFRIRQLVTKADGTVAAEIEAVGGLMDLGERRLVPDPRQRFKELAARPELFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKW8</accession>
    <name>Q9RKW8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1409</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625691.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977417.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1409"/>
    <dbReference type="GeneID" id="1096835"/>
    <dbReference type="KEGG" id="sco:SCO1409"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1419"/>
    <dbReference type="eggNOG" id="ENOG5032S76">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026989_0_0_11"/>
    <dbReference type="OMA" id="YRTVQYS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="508" mass="55004" checksum="FCFE14B0E4762FBA" modified="2000-05-01" version="1">MTSPASTDSVPPQLSAGPRPAPGPAADEGLARRLRALACTAPLHDLDARKANLAGEYSVYGMAEVALAAIDLVTLNMDFDTGADHDQIVARLIPRVAAQAPHRPAAEHERVARWVLENLINVGSVDRGFRAVYGTFGPDGTYVRRDYDFKLLEEVPGPGGTVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLINRGRLADAQLAAEQARYRTVQYSETLRRALDATRRNVRAVDWLSAVPDMIAEALDHVADRYRHENAILTNIRKARDETEDAEHKRRAAELVDIVKDCIRRHTQLQSRLLEAGPLFRAEQDRQAFATPLTTSGLDLYGHLVAPVLPLPVESALRVTDAFFARGTGLRTPVSVRVGDLVDILLTPPVEREHLGAEMPEPDLIATPDDSRFSEEQLAAAMELLDLPHDAPRRLSGLLADARARDAELPYLVALLAVHAASPPVGTAYRQGEPKLLFAVDDGTELDDPEFGGADLIVGTALLDAAGMAADRTEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL37</accession>
    <name>Q9RL37_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0450</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624770.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027126.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0450"/>
    <dbReference type="GeneID" id="1095873"/>
    <dbReference type="KEGG" id="sco:SCO0450"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.428"/>
    <dbReference type="eggNOG" id="COG3447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052655_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RL37"/>
    <dbReference type="OMA" id="WWVGDAM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MASE1" evidence="7">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB56680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="329" mass="34129" checksum="43D0FD35F12CED60" modified="2000-05-01" version="1">MAAVVGIRAWPRPVVLTCATLLLAGCYYAAGRLGLSQQLTADGSVVTPIWPPTGLAVACLLLFGPWCVPGIALGALLVIVSLGAPGPEAAGIVVGNTAAPVCAWLLLRAVGFRLSLSRLRDGLALVFLGALAAMLISSCTGIGMLLLSGKLPTDHLGIVWLAWWVGDAMGVVLVTPLLLLLYRARLPPPSARWPEAAGLTAVVCVLVPLIMYSSVSVLFLAYPILIWSALRFQLAGGIPCALFVSVTATVVARQEAGSFGKLTDIETMMKLQAFNGTLGLTALLLSAVISEQLNTRRSVERACHELVEALQHLNAGGSGAPGPPGGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL49</accession>
    <name>Q9RL49_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0437</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624758.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027115.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0437"/>
    <dbReference type="GeneID" id="1095860"/>
    <dbReference type="KEGG" id="sco:SCO0437"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.414"/>
    <dbReference type="eggNOG" id="ENOG502Z7RS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042917_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RL49"/>
    <dbReference type="OMA" id="GCFDWHS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="36899" checksum="0F20413E7E64421C" modified="2000-05-01" version="1">MPLSTHAARFAQLALANITREYPNFPAHLITSADERPEPRSLHPAFYGAYDWHSSVHMHWLLVRLLRRHGGTSALPGTEEAVAALDRHLTPGNLATEAAYLRERPSFERPYGWAWLLALAAECRALGGPEGQRWAGALEPAVDAVDALLADWLPKATYPVRHGNHPNSAFALGLALDSGELPAGTERAVRERLLSWFADDHDAPAHWEPSGQDFLSPALTEADAMRRVLAPDRLARWLDRFLPGLGTGARCALLEVPVVSDHADPQIGHLLGLTLSRAAALRALADALPDGPVRARLDKAAGAHLTAGLPAVERGDFTTDHWLATFAALALDPVAPPAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Q0</accession>
    <name>Q9S1Q0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37156">
        <property type="entry name" value="T37156"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624573.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026950.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0241"/>
    <dbReference type="GeneID" id="1095665"/>
    <dbReference type="KEGG" id="sco:SCO0241"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.214"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092792_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S1Q0"/>
    <dbReference type="OMA" id="AVWTHAR"/>
    <dbReference type="PhylomeDB" id="Q9S1Q0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041483">
        <property type="entry name" value="TetR_C_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17929">
        <property type="entry name" value="TetR_C_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24135" checksum="386DB4B473CF7245" modified="2000-05-01" version="1">MTNFQRARSEEQRAVRRQAILDTTAAMLEEMPVGEVSLNELSRRVGLAKSNVLRYFESREAILLELLDRAWQQWVADLPALVHAGVDQGAPVSRRAEQFAAVIAASLAGRQVLCDLLSAQAGVLEHNVSPQVAARYKRAAVANVADIAALAHQHLPELGASAPQLTAVMIMAVGAVWTHARPSPAMLSAYEADPSLTAFKLDFVTTLQEMLATLTAGTIARESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S252</accession>
    <name>Q9S252_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36801">
        <property type="entry name" value="T36801"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625974.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977125.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1700"/>
    <dbReference type="GeneID" id="1097131"/>
    <dbReference type="KEGG" id="sco:SCO1700"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1718"/>
    <dbReference type="eggNOG" id="COG4298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172326_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S252"/>
    <dbReference type="OMA" id="LAEHDPF"/>
    <dbReference type="PhylomeDB" id="Q9S252"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038972">
        <property type="entry name" value="YiaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008024">
        <property type="entry name" value="YiaAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37290">
        <property type="entry name" value="PTHR37290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05360">
        <property type="entry name" value="YiaAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="YiaAB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="104" mass="11289" checksum="D7E9646879DFA4DB" modified="2000-05-01" version="1">MSDTPVKQQNTAAFYGQAVASFAVAMAATAIGIYQLQADAWVRAFLAIAVLYLVTSAFTLAKIIRDRQEVGQIVSRVDQARLDRILVEHDPFQKPGGTPAGQRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2G5</accession>
    <name>CLPS_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name type="ordered locus">SCO2916</name>
        <name type="ORF">SCE19A.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB50997" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50997.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36139">
        <property type="entry name" value="T36139"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627142.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2G5"/>
    <dbReference type="SMR" id="Q9S2G5"/>
    <dbReference type="STRING" id="100226.SCO2916"/>
    <dbReference type="GeneID" id="1098349"/>
    <dbReference type="KEGG" id="sco:SCO2916"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2974"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153743_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2G5"/>
    <dbReference type="PhylomeDB" id="Q9S2G5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000215752" description="ATP-dependent Clp protease adapter protein ClpS">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="96" mass="11054" checksum="5DAFF4D8CB25CA52" modified="2001-01-11" version="2">MEIEKTESAEEVFAVPEPDVPWVTIVHNDPVNLMSYVTYVFQSYFGYSKDKATKLMMDVHHKGRAVVSSGSREEMERDVQAMHGYGLWATLQQDRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U8</accession>
    <name>LGT1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase 1</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt1</name>
        <name type="ordered locus">SCO2034</name>
        <name type="ORF">SC4G6.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35063">
        <property type="entry name" value="T35063"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626294.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976782.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2U8"/>
    <dbReference type="SMR" id="Q9S2U8"/>
    <dbReference type="STRING" id="100226.SCO2034"/>
    <dbReference type="GeneID" id="1097468"/>
    <dbReference type="KEGG" id="sco:SCO2034"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2065"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_2_2_11"/>
    <dbReference type="InParanoid" id="Q9S2U8"/>
    <dbReference type="OMA" id="HQYLFFI"/>
    <dbReference type="PhylomeDB" id="Q9S2U8"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172685" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase 1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="343" mass="36803" checksum="E11969E40BE7C8E1" modified="2000-05-01" version="1">MELAFIPSPSRGVLHLGPVPLRGYAFCIIIGVFVAVWLGNKRWVARGGRPGTVADIAVWAVPFGLIGGRLYHVITDYQLYFSEGRDWVDAFKIWEGGLGIWGAIAFGAVGAWIGARRRGVPMPAYADAVAPGIALAQAIGRWGNWFNQELYGKATDLPWAVEITSTADGRVPGTYHPTFLYESLWCIGVALLVIWADRRFKLGHGRAFALYVAAYCAGRFWIEYMRVDDAHHILGLRLNNWTALFVFLLAVLYIVLSARKRPGREAVVEPGAETAAGDSGSAADKDVKGTKDAEDAEGAEDGAEKTDASGATEAPEDTSGADEADAAKDAEGVTNGADSAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8D9</accession>
    <name>Q9X8D9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3266</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36226">
        <property type="entry name" value="T36226"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627478.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028873.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3266"/>
    <dbReference type="GeneID" id="1098700"/>
    <dbReference type="KEGG" id="sco:SCO3266"/>
    <dbReference type="eggNOG" id="ENOG5031YHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200600_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB40324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="7050" checksum="5A18DD04BE1BDA24" modified="1999-11-01" version="1">MPRRRQPHIADPASVPYRSTACRIGTHHVCADASPTPVPADIPVICEACDCPCHSGVGLSASLEVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA39</accession>
    <name>Q9XA39_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3574</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36559">
        <property type="entry name" value="T36559"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627771.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029094.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3574"/>
    <dbReference type="ESTHER" id="strco-SCH17.08C">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1099010"/>
    <dbReference type="KEGG" id="sco:SCO3574"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3630"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_2_11"/>
    <dbReference type="InParanoid" id="Q9XA39"/>
    <dbReference type="OMA" id="FYVSYFQ"/>
    <dbReference type="PhylomeDB" id="Q9XA39"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="354" mass="38123" checksum="4F1305498E0FAC13" modified="1999-11-01" version="1">MPQPPVTDQQTGERDTRQDGRPGQAAGRPVHRLVPSPAGRIHLVEQGSGPLVLLVHGFPESWYSWRHQLPALAAAGFRAVALDVRGYGRSSRPDAVEAYRMLDLVADNVAVVEALGESSAVVVGHDWGANIAAHSALLRPDVFRAVGLLSVPYTPPGGPRPSEAFAGMSDPAGPFAGQEFYVSYFQEPGRAEAEIEPDVRGWLAGLYAALSAGTMPGPQDPDPHFVAPGGRMRDRFPSAGRLPSWLTEEDLDVYAGEFERTGLTGALNRYRNMDRDWADLAAHEGAPITQPSLFLGGALDASTTWLSDAIEAYPVTLPGLSASHLLDGCGHWLQQERPEETNRLLTEWLTGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA50</accession>
    <name>Q9XA50_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3828</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36509">
        <property type="entry name" value="T36509"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628017.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029254.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3828"/>
    <dbReference type="GeneID" id="1099264"/>
    <dbReference type="KEGG" id="sco:SCO3828"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3897"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XA50"/>
    <dbReference type="OMA" id="FDCDTWD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6457" evidence="6">
        <location>
            <begin position="196"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB46951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="31118" checksum="DCB484C5B1046371" modified="1999-11-01" version="1">MLAGGAARRLGGADKPGLRVGGRPLLDRVLAACAGARRTVVVADPRPTARPVTWAREDPPGGGPLAALAAGLRHTTAEYVLVASADLPFLAGPTVGRLLSALAAGDADGVLLTDADGRDQPLVAAYRAPALRRELAALARNRAGRGERADGAQLTGLPLRRLTGALRLTRVPDAVAAFDCDTWDDLATARARIREHGHVLDEWISAAKDELGIDLDVDTGILLDLARDAAHGVARPAAPLTTFLVGYAAGRAGGGPEAVAETARKAAALAQRWAEEAADTGSAPARGKPDVAPDATPDTRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA54</accession>
    <name>Q9XA54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC-transporter ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3824</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36505">
        <property type="entry name" value="T36505"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628013.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029252.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3824"/>
    <dbReference type="GeneID" id="1099260"/>
    <dbReference type="KEGG" id="sco:SCO3824"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3893"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9XA54"/>
    <dbReference type="OMA" id="ITAPMAD"/>
    <dbReference type="PhylomeDB" id="Q9XA54"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB46947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="342" mass="35624" checksum="C5FDBE9363EEA9DC" modified="1999-11-01" version="1">MSTHTSGLAIETAGLVKTFGETRAVDGVDLAVPAGTVYGVLGPNGAGKTTTVKMLATLLRPDGGHARVFGHDVVHEADEVRGRVSLTGQYASVDEDLTGTENLVLLGRLLGHGKAAARERGDQLLAAFGLTDAAAKQVKHYSGGMRRRIDIAASILNTPDLLFLDEPTTGLDPRSRNQVWDIVRAVVAQGTTVLLTTQYLDEADQLASRIAVIDKGRVIAEGTKGELKASVGAGSVHLRLRDAEERPEAERVLRNLLVAEVQPEPDPVALTARLGAAASDTAADQAAKALGELARAGITVDSFSLGQPSLDEVFLALTGHDTGQSTDGDSGTGTDKKDGVAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z512</accession>
    <name>UVRC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">SCO1953</name>
        <name type="ORF">SCC54.13c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36026">
        <property type="entry name" value="T36026"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626217.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028063.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z512"/>
    <dbReference type="SMR" id="Q9Z512"/>
    <dbReference type="STRING" id="100226.SCO1953"/>
    <dbReference type="GeneID" id="1097387"/>
    <dbReference type="KEGG" id="sco:SCO1953"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1979"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_1_1_11"/>
    <dbReference type="InParanoid" id="Q9Z512"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="PhylomeDB" id="Q9Z512"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138345" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="728" mass="80841" checksum="6DFDD3439BEBADD6" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z515</accession>
    <accession>Q9S4Y1</accession>
    <name>WHIA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">whiA</name>
        <name type="ordered locus">SCO1950</name>
        <name type="ORF">SCC54.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="5470" last="5478">
            <title>WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Ainsa J.A."/>
                <person name="Ryding N.J."/>
                <person name="Hartley N."/>
                <person name="Findlay K.C."/>
                <person name="Bruton C.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="10986251"/>
            <dbReference type="DOI" id="10.1128/JB.182.19.5470-5478.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF LEU-160 AND LEU-194</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>POSSIBLE OPERON STRUCTURE</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="1710" last="1720">
            <title>Developmental control of a parAB promoter leads to formation of sporulation-associated ParB complexes in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Jakimowicz D."/>
                <person name="Mouz S."/>
                <person name="Zakrzewska-Czerwinska J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="16484182"/>
            <dbReference type="DOI" id="10.1128/JB.188.5.1710-1720.2006"/>
        </citation>
        <scope>FUNCTION IN PARB EXPRESSION</scope>
        <scope>REGULATION MODEL</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2007" name="Cell Cycle" volume="6" first="1666" last="1670">
            <title>Bacterial DUF199/COG1481 proteins including sporulation regulator WhiA are distant homologs of LAGLIDADG homing endonucleases that retained only DNA binding.</title>
            <authorList>
                <person name="Knizewski L."/>
                <person name="Ginalski K."/>
            </authorList>
            <dbReference type="PubMed" id="17603302"/>
        </citation>
        <scope>SUGGESTION OF DNA-BINDING</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="FEMS Microbiol. Rev." volume="30" first="651" last="672">
            <title>The evolution of development in Streptomyces analysed by genome comparisons.</title>
            <authorList>
                <person name="Chater K.F."/>
                <person name="Chandra G."/>
            </authorList>
            <dbReference type="PubMed" id="16911038"/>
            <dbReference type="DOI" id="10.1111/j.1574-6976.2006.00033.x"/>
        </citation>
        <scope>REVIEW</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2011" name="Sci. Rep." volume="1" first="156" last="156">
            <title>DNA recognition and transcriptional regulation by the WhiA sporulation factor.</title>
            <authorList>
                <person name="Kaiser B.K."/>
                <person name="Stoddard B.L."/>
            </authorList>
            <dbReference type="PubMed" id="22355671"/>
            <dbReference type="DOI" id="10.1038/srep00156"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DNA-BINDING</scope>
        <scope>SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3 4">Involved in cell division and chromosome segregation (By similarity). Involved in sporulation (PubMed:16484182, PubMed:22355671). May coordinate the cessation of aerial hyphae growth and subsequent chromosome segregation and/or septation (PubMed:16484182, PubMed:22355671). Required for expression of the ParB partioning protein during sporogenesis. Activates its own transcription and represses WhiB (PubMed:16484182). Binds with low affinity to its own promoter and to the Parp2 sporulation-specific promoter. Also binds directly to the RNA polymerase sigma factor WhiG, leading to inhibition of WhiG-dependent transcription in a dose-dependent manner (PubMed:22355671).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer in solution.</text>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Induced when aerial mycelia start forming, expression is maximal when sporulation starts.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 4">Transcribed both as part of an operon and from its own specific promoter during sporulation (PubMed:10986251). Transcription is stimulated by WhiG (PubMed:22355671).</text>
    </comment>
    <comment type="domain">
        <text evidence="4">DNA binding is primarily driven by the H-T-H domain, but requires full-length protein for maximum affinity.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Cells lacking this gene do not sporulate; instead of aerial hyphae of unicellular spores, long slightly coiled unseptated stalks form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">There may be second mutations present in each of mutant strains C58 and C213.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB38140" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AF106003">
        <property type="protein sequence ID" value="AAD42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38140.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36023">
        <property type="entry name" value="T36023"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626214.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028060.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z515"/>
    <dbReference type="SMR" id="Q9Z515"/>
    <dbReference type="STRING" id="100226.SCO1950"/>
    <dbReference type="PRIDE" id="Q9Z515"/>
    <dbReference type="GeneID" id="1097384"/>
    <dbReference type="KEGG" id="sco:SCO1950"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1976"/>
    <dbReference type="eggNOG" id="COG1481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053282_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z515"/>
    <dbReference type="OMA" id="CDAEAAW"/>
    <dbReference type="PhylomeDB" id="Q9Z515"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000376600" description="Probable cell division protein WhiA">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Aerial hyphae have coiled segments and no signs of septation (strain C85)." evidence="2">
        <original>L</original>
        <variation>P</variation>
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Aerial hyphae have coiled segments and no signs of septation (strain C213)." evidence="2">
        <original>L</original>
        <variation>P</variation>
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="10986251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16484182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22355671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="328" mass="34738" checksum="6C7E48744A537947" modified="1999-05-01" version="1">MTAAVKSEISQLPVTRTCCRKAEVSAVLRFAGGLHLVSGRIVIEAELDTGNAARRLKRDILEIFGHSSELIVMAPGGLRRGSRFVVRVVAGGDQLARQTGLVDGRGRPIRGLPPQVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEVTCPGPEAALALVGAARRLSIPAKAREVRGVDRVVVRDGDAIGALLTRLGAHDSVLAWEERRLRREVRATANRLANFDDANLRRSARAAVAAGARVQRALEILADDVPEHLAAAGRLRMEHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRASDLGIAGTDANLGEEELADNLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z530</accession>
    <name>Q9Z530_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO5711</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35984">
        <property type="entry name" value="T35984"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629838.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973315.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5711"/>
    <dbReference type="GeneID" id="1101150"/>
    <dbReference type="KEGG" id="sco:SCO5711"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5801"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z530"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="PhylomeDB" id="Q9Z530"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006771">
        <property type="term" value="P:riboflavin metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB37472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="34587" checksum="DFA51833FADD966C" modified="1999-05-01" version="1">MQRWRGLEDIPEDWGRSVVTIGSYDGVHRGHQLIIRHAVDRARELGVPAVVVTFDPHPSEVVRPGSHPPLLAPHHRRAELMADLGVDAVLILPFTKEFSKLSAADFVVKVLVDRLRAKAVVEGPNFRFGHKAAGNVDFLIEQGKVYDFEVEVVDLYVTGDAGGGEPFSSTLTRRLVAEGDVAGAAEILGRPHRVEGVVVRGAQRGREMGFPTANVETLPHTAIPADGVYAGWLHAQGEAMPAAISVGTNPQFEGTERTVEAYAIDRVGLELYGLHVAVDFVAFVRGQAKFETLDALLEQMAVDVDRCREITATDAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z594</accession>
    <name>Q9Z594_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6208</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34862">
        <property type="entry name" value="T34862"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630311.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972719.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6208"/>
    <dbReference type="GeneID" id="1101649"/>
    <dbReference type="KEGG" id="sco:SCO6208"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6322"/>
    <dbReference type="eggNOG" id="COG2964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2036347_0_0_11"/>
    <dbReference type="OMA" id="MERRHGM"/>
    <dbReference type="PhylomeDB" id="Q9Z594"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_22" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB36616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="122" mass="13225" checksum="CAE9EE7010DAE348" modified="1999-05-01" version="1">MTGPAEEPFIAAVKPLVDAMGGEMLPPDEAGLEDVVLSWEGADVVAVRLPQLADSLDHILAAMERRQGRPLADLDRRTKQEVVRALEARGAFAVRHGVETVASALGVSRFTVYNYLNREKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBY3</accession>
    <name>Q9ZBY3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible secreted peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3949</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36055">
        <property type="entry name" value="T36055"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628133.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029334.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3949"/>
    <dbReference type="GeneID" id="1099385"/>
    <dbReference type="KEGG" id="sco:SCO3949"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4021"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787351_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBY3"/>
    <dbReference type="OMA" id="GQWIGQS"/>
    <dbReference type="PhylomeDB" id="Q9ZBY3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177082" evidence="2">
        <location>
            <begin position="29"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="349" mass="37226" checksum="1C2630D21D42D675" modified="1999-05-01" version="1">MCSSRRRPLLVPVLLCALALLAARPTDGMDGDTGPGAGLGPQVARLYEDAAKATRQYEDGRREAEAQRSKALEYERRLDGQRQKIDAMHEDLGRIARAQYRDGGGLPLTARMLLADDPEELMRGQRAVSRANLAVDRAIGKNLRAEARLADQEAGARAAWQALEKRNAGLAKLKKEIESKLEVVRSRLEGQADSSVAAGACPGAVRLDQPDVPSGPSWVAPVEAYELSASFGSGGSRWAHRHTGQDFAVPVGTPVRSVGTGRVLKVSCGGAFGIQVVIEHAGGYYTQYAHLAAVAVDQGDRVDAGQWIGQSGSTGNSTGPHLHFEVRVTPDMGSALDPVPWLSQRGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZC10</accession>
    <name>Q9ZC10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6503</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34733">
        <property type="entry name" value="T34733"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630585.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030970.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6503"/>
    <dbReference type="GeneID" id="1101942"/>
    <dbReference type="KEGG" id="sco:SCO6503"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6605"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078525_0_0_11"/>
    <dbReference type="OMA" id="INVKCAL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="25260" checksum="A912F14E478BF5BC" modified="1999-05-01" version="1">MNRVGLGLAIGAGYLLGRTKKLKMAVAVGTMVAGKKLNLTPKGIAELVSGQLQNNPQFKEIGDQLRTDLRGVGKAASGAMVERQIDALADRLHGRTAEVRDQLSGVASRAPGTGSDDSDDSRDSEASEDSEYEEAREREEPEEHQDAEEPQQAEESEESEESEERRAPRRARPAKKASPETRGTAGKAPAKKAAAKAPAKKAAAKRAQPAKKAAGKKTAGARNAARGAGARRSKDGGER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-15" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZNB0</accession>
    <name>Y742_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized ABC transporter ATP-binding protein SCO0742</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO0742</name>
        <name type="ORF">3SC5B7.20</name>
        <name type="ORF">SCF81.01</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-11" db="EMBL/GenBank/DDBJ databases">
            <title>ABC transporter and alcohol dehydrogenase genes from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Ogawara H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AB019513">
        <property type="protein sequence ID" value="BAA34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAD55276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978119.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZNB0"/>
    <dbReference type="SMR" id="Q9ZNB0"/>
    <dbReference type="STRING" id="100226.SCO0742"/>
    <dbReference type="GeneID" id="1096165"/>
    <dbReference type="KEGG" id="sco:SCO0742"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.732"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_11"/>
    <dbReference type="InParanoid" id="Q9ZNB0"/>
    <dbReference type="OMA" id="ERANASC"/>
    <dbReference type="PhylomeDB" id="Q9ZNB0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093277" description="Uncharacterized ABC transporter ATP-binding protein SCO0742">
        <location>
            <begin position="1"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="342"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="584" mass="61507" checksum="2DFC6F248A2FD5CD" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-04-07" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O50502</accession>
    <name>O50502_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable transcriptional repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6008</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA15785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35673">
        <property type="entry name" value="T35673"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630122.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972914.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6008"/>
    <dbReference type="GeneID" id="1101450"/>
    <dbReference type="KEGG" id="sco:SCO6008"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6106"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="InParanoid" id="O50502"/>
    <dbReference type="OMA" id="VDFGHTH"/>
    <dbReference type="PhylomeDB" id="O50502"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA15785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="403" mass="40960" checksum="E17CAD0AAEA2A1F5" modified="1998-06-01" version="1">METPGSQSSLHRANLERVVRAVRLAGSLTQAEIARTTGLSAATVSNIVRELKDGGTVEVTPTSAGGRRARSVSLSGDAGIVIGVDFGHTHLRVAVGNLAHQVLAEESEPLDVDASSDQGFDRAEQLVSRLIEATGVDRAKIAGVGLGVPGPIDVESGTLGSTAILPGWGGIRPAEELRGRLGVPVHVDNDANLGALGELVWGGGRGVRDLAYIKVASGVGAGLVINGKIYRGPGGTAGEIGHITLDEAGPVCRCGNRGCLETFAAARYVLPLLQPSHGTDLTMEGVVRLARDGDPGCRRVIADVGRHIGSGVANLCNLLNPSRVVLGGDLAEAGELVLGPIRESVGRYAIPSAARQLSVLPGALGGRAEVLGALALALSEMGDSTLLDGSATGALPAATPAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>O54103</accession>
    <name>O54103_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5907</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34579">
        <property type="entry name" value="T34579"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630025.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030526.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5907"/>
    <dbReference type="GeneID" id="1101349"/>
    <dbReference type="KEGG" id="sco:SCO5907"/>
    <dbReference type="HOGENOM" id="CLU_3317465_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA16444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="39" mass="4132" checksum="30ED11E9BAD9497C" modified="1998-06-01" version="1">MTNERTTNVNALNALVRVVDVVIDGRRALTGRPPGGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="146" xmlns="http://uniprot.org/uniprot">
    <accession>O54155</accession>
    <name>O54155_STRCO</name>
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        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO5892</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T34918"/>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO5892"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5991"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_67_1_11"/>
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    <dbReference type="PhylomeDB" id="O54155"/>
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        <property type="reaction ID" value="UER00071"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
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        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
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    </dbReference>
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        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
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        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="698"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1670"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1770"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAA16183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="2297" mass="241991" checksum="C67B58461535EE46" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>O69920</accession>
    <name>O69920_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6388</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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    <dbReference type="GeneID" id="1101829"/>
    <dbReference type="KEGG" id="sco:SCO6388"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="12450" checksum="3EA3301B19342BCB" modified="1998-08-01" version="1">MTGSRVGGADPLPPGDHGLVGGAQPHVTAVALADAHPCTSVVTLALIHPSSCVVHELLPRVSVEVAFLAVIVGRLVHRLDVEAAGEDQTSHGYALQSTSLPERKFHRDSFARPGPRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O69959</accession>
    <name>O69959_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5783</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35103">
        <property type="entry name" value="T35103"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629907.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973240.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5783"/>
    <dbReference type="GeneID" id="1101225"/>
    <dbReference type="KEGG" id="sco:SCO5783"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5873"/>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116143_1_0_11"/>
    <dbReference type="InParanoid" id="O69959"/>
    <dbReference type="OMA" id="EGAYFQP"/>
    <dbReference type="PhylomeDB" id="O69959"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="17131" checksum="B6FB63F3205000C2" modified="1998-08-01" version="1">MSAPRLRATPLPGIGVQYDLVTREHRHLSVVAHRDGARTVNVYRSDDPDSCAHSLRLTGPEAGALIDALKPSHHSASLLYTTDLGLVAERIEVAATSRWNGRLLGDTRLRTDTGASIVAVLRRAEAIPSPAPDFRLVGGDTLIVIGTREGVDAAAAILGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O69983</accession>
    <name>O69983_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4937 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5807</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35127">
        <property type="entry name" value="T35127"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629931.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030469.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5807"/>
    <dbReference type="GeneID" id="1101249"/>
    <dbReference type="KEGG" id="sco:SCO5807"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5899"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114411_1_0_11"/>
    <dbReference type="OMA" id="WNPAMAG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032555">
        <property type="entry name" value="DUF4937"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16291">
        <property type="entry name" value="DUF4937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4937" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="25500" checksum="3735D3B5B1755791" modified="1998-08-01" version="1">MRASGPAESGRRRVPWPYDGAVLVKWIRCTVVDRRGFERGQRKWAGLPGEPGFRGQGGGWSRGRPDVAHVFAFWESRAFYDSFMARSHDRLASAQAGTFKDAQVRLFDYRFDVKTGFEPRFTDADLLRVALCRVHEERSEHYVLMQEKVWNPAMAGSPGMIRGLFGEAPGNGYNEYLVLSMWLSAAEHGKYRTERVERLALRAQTEADIAALTGDIVQLEPSWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O69990</accession>
    <name>O69990_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35187">
        <property type="entry name" value="T35187"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629936.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030472.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5813"/>
    <dbReference type="GeneID" id="1101255"/>
    <dbReference type="KEGG" id="sco:SCO5813"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5905"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127700_0_0_11"/>
    <dbReference type="OMA" id="HPWAAHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="21328" checksum="EEE86243AAF3428C" modified="1998-08-01" version="1">MPLIPEEPQIHEKAQGPRATPASGRTAPTPRPVPGPRPAAPPRPGRPGPVRPAPPAQRATRDTAATPGPSGPAAPAAPEATSAAPQIQLIPATPDGALDAAEEAVDLLLDSGRTPGDVLVITTGELHPWAAHELSFGDAAYWAQHDAGDDVFYTDATVADRAASRAVVVVALNGGPEAAAVTALTAAHSRAGALLIVCGDPQRINSVLGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O86555</accession>
    <name>O86555_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6621</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29127">
        <property type="entry name" value="T29127"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630698.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031048.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6621"/>
    <dbReference type="GeneID" id="1102060"/>
    <dbReference type="KEGG" id="sco:SCO6621"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6728"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660417_0_0_11"/>
    <dbReference type="InParanoid" id="O86555"/>
    <dbReference type="OMA" id="KLRWTYN"/>
    <dbReference type="PhylomeDB" id="O86555"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="424" mass="45064" checksum="48A286A78C197D8C" modified="1998-11-01" version="1">MVRRDSGSDDRTPGAFGAPSRRRVLRLAGGGLALAALTAGTVGCDEDSVDVEDPGSTGGDEPKGGGNGSGDGGDVGEKGQAPKPLWTKPTSAETYGDNDELVAAGGVVIASGSPLAALDAATGGQKWSLPGGAVPGAPLLLSEDTLYLASSEYDGSVIGYAPASGKETWRSRLGKEYRQPRPIAVDEEQVYVLAEILEEDGSSKTNVIAALDSTTGRIAWKEQRDVGTEQNGIHAAVRGRHLVYTDFKKNLTVRDTASGGQVWTHKTTRTNYGFFTVHQDLVIVPQGNVLQAFNLADGKEKWSLKASDGALFREPAVLEDVLYVADSARTMWAVDPRTGRQLWKSEALADAELQVPRQYVKAGDTLYGATDLDKQGGIIAIDARTGEVRWTFNDKTGDYHAWLVATDGKRVFALHGKKLHALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O86637</accession>
    <name>O86637_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5717</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629843.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030409.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5717"/>
    <dbReference type="GeneID" id="1101156"/>
    <dbReference type="KEGG" id="sco:SCO5717"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5807"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003609_3_0_11"/>
    <dbReference type="InParanoid" id="O86637"/>
    <dbReference type="OMA" id="YGFPQQG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051782">
        <property type="term" value="P:negative regulation of cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="710"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1083" mass="112084" checksum="AD42EDFE4C12126D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-27" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O87840</accession>
    <name>SUCC2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate--CoA ligase [ADP-forming] subunit beta 2</fullName>
            <ecNumber evidence="1">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Succinyl-CoA synthetase subunit beta 2</fullName>
            <shortName evidence="1">SCS-beta 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sucC2</name>
        <name type="synonym">sucC</name>
        <name type="ordered locus">SCO6585</name>
        <name type="ORF">SC8A6.06</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35773">
        <property type="entry name" value="T35773"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630664.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031022.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O87840"/>
    <dbReference type="SMR" id="O87840"/>
    <dbReference type="STRING" id="100226.SCO6585"/>
    <dbReference type="GeneID" id="1102024"/>
    <dbReference type="KEGG" id="sco:SCO6585"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6690"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_11"/>
    <dbReference type="InParanoid" id="O87840"/>
    <dbReference type="OMA" id="AIQQFKV"/>
    <dbReference type="PhylomeDB" id="O87840"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000102870" description="Succinate--CoA ligase [ADP-forming] subunit beta 2">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <sequence length="383" mass="40162" checksum="5A3D05C0FD11DD03" modified="1998-11-01" version="1">MDLYEHQARELFKEHGIVVPRAEVTDSPERAREIARALGGRAVVKAQVKTGGRGKAGGVRLAADPAEAEEAARHILGMDIRGHTVDTVMLAEPCEIEREFYVSYVLDRASGGFLAIASAEGGTEIEEVAARRPEAVARIPVDPATGVHTATAVRIADAAGLPPQTVDTLVRLWKVLVREDALLVEVNPLVRTAEGRIVALDGKVTLDDNARFRQSRWGETRQEDADSLEARAGAKGLNYVKLDGEVGVIGNGAGLVMSTLDVVAGCGARPANFLDIGGGASARVMADGLSVVLSDPDVRSVLVNVFGGITACDAVADGIVRALDEVRLTKPLVVRLDGNNAARGRALLDARAHPLVEQATTMDGAARRAARLATAASTAGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O88044</accession>
    <name>O88044_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1584</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36819">
        <property type="entry name" value="T36819"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625860.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1584"/>
    <dbReference type="GeneID" id="1097015"/>
    <dbReference type="KEGG" id="sco:SCO1584"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1596"/>
    <dbReference type="eggNOG" id="ENOG5032ZC5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093209_1_0_11"/>
    <dbReference type="InParanoid" id="O88044"/>
    <dbReference type="OMA" id="HPCAADL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="1">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="16748" checksum="53B4579E35B5AC30" modified="1998-11-01" version="1">MEMGELWPVPDVLAYLAGHWRTARSVRDLAGGLEGRFEGRTSFDALDGGGLIGRESGAFTWQGVTRPAERTLRYEPGSGPGRVDVRFADGRPFHGLDLSSGHHVADHPCAADLYRGEFTVRGPDRWRTVWRVGGPAKDLLLTTDYLRETPDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-02-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>P49399</accession>
    <accession>Q9L0C6</accession>
    <name>RS8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">SCO4716</name>
        <name type="ORF">SCD31.41</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1994-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Loriaux A."/>
                <person name="Brans A."/>
                <person name="Dusart J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-132</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X83011">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S50000">
        <property type="entry name" value="S50000"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628875.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974254.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P49399"/>
    <dbReference type="SMR" id="P49399"/>
    <dbReference type="STRING" id="100226.SCO4716"/>
    <dbReference type="GeneID" id="1100157"/>
    <dbReference type="KEGG" id="sco:SCO4716"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4787"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_1_11"/>
    <dbReference type="InParanoid" id="P49399"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="PhylomeDB" id="P49399"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126494" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="132" mass="14277" checksum="57943D3C5876DDB8" modified="2001-10-18" version="2">MTMTDPIADMLTRLRNANSAYHDSVTMPASKIKSHIAEILQQEGFITGWKTEDAEVGKNLTLELKFGPNRERSIAGIKRISKPGLRVYAKSTNLPKVLGGLGVAIISTSHGLLTDKQAGKKGVGGEVLAYVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKQ6</accession>
    <accession>O87599</accession>
    <name>PSA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prcA</name>
        <name type="ordered locus">SCO1643</name>
        <name type="ORF">SCI41.26</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5448" last="5453">
            <title>The 20S proteasome of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Nagy I."/>
                <person name="Tamura T."/>
                <person name="Vanderleyden J."/>
                <person name="Baumeister W."/>
                <person name="De Mot R."/>
            </authorList>
            <dbReference type="PubMed" id="9765579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>SUBUNIT</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>TEMPERATURE DEPENDENCE</scope>
        <scope>BLOCKAGE OF N-TERMINUS</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1 3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity (By similarity). Peptidolytic activity is completely inhibited by lactacystin, and to a lesser extent, by N-acetyl-Leu-Leu-norleucinal (Ac-LLnL) and benzoyloxycarbonyl-Leu-Leu-Leu-vinylsulfone (Z-LLL-VS) in vitro.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <temperatureDependence>
            <text evidence="3">Optimum temperature is 55 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has probably a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is likely capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text>The N-terminus is blocked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="AF086832">
        <property type="protein sequence ID" value="AAC64278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625918.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027897.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7AKQ6"/>
    <dbReference type="SMR" id="Q7AKQ6"/>
    <dbReference type="STRING" id="100226.SCO1643"/>
    <dbReference type="MEROPS" id="T01.011"/>
    <dbReference type="GeneID" id="1097074"/>
    <dbReference type="KEGG" id="sco:SCO1643"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1658"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071031_0_0_11"/>
    <dbReference type="InParanoid" id="Q7AKQ6"/>
    <dbReference type="OMA" id="QIYRLPH"/>
    <dbReference type="PhylomeDB" id="Q7AKQ6"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383484" description="Proteasome subunit alpha">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="9765579"/>
        </source>
    </evidence>
    <sequence length="254" mass="27883" checksum="97460DA9883C33D8" modified="2004-07-05" version="1">MSTPFYVSPQQAMADRAEYARKGIARGRSLVVLQYADGIVFVGENPSRALHKFSEIYDRIGFAAAGKYNEYENLRIGGVRYADLRGYTYDRDDVTARGLANVYAQTLGTIFSSQAEKPYEVELVVAEVGDSPENDQIYRLPHDGSIVDEHGSVAVGGNAEQISGYLDQRHRDGMTLAEALKLAVQALSRDTNGTEREIPAERLEVAVLDRTRPQQRKFKRIVGGQLSRLLESGAASADGEAETEAETDSGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK6</accession>
    <name>Q8CJK6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAD55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031506.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7202"/>
    <dbReference type="GeneID" id="1102640"/>
    <dbReference type="KEGG" id="sco:SCO7202"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7301"/>
    <dbReference type="eggNOG" id="ENOG5031IYK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1128531_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="25080" checksum="9F4FAFE21F0BFD1C" modified="2003-03-01" version="1">MSRGRRGPSTGGLHAAAHVRAMVWGPAEFTGLPPRWLIGEGLFAGVLGSGLIVGAGVFGTWTGESAFAEGEVGLACALGLVLHLLLVRAGRAMVGIVAVLAVGLALHTPQAAAGVVLTARGQERSVVVTSVRASEEASGARGRYFCSVEGRDGAPSTARIWRGCTRSVRPGDSLALVYDPKGLVPPRGVEGATSIVDALRSLAGWVVGLVVACVTAVVRSFRLLDRPVASGSAHPGGRGATHQGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJP2</accession>
    <name>Q8CJP2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptide-binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6114</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAD55371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35897">
        <property type="entry name" value="T35897"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030659.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6114"/>
    <dbReference type="GeneID" id="1101555"/>
    <dbReference type="KEGG" id="sco:SCO6114"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6217"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_1_11"/>
    <dbReference type="InParanoid" id="Q8CJP2"/>
    <dbReference type="OMA" id="CKWQLSF"/>
    <dbReference type="PhylomeDB" id="Q8CJP2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176126" evidence="1">
        <location>
            <begin position="36"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="98"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="602" mass="65899" checksum="57F2ADF48D246B0D" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJZ1</accession>
    <name>Q8CJZ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2590</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAD55196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733577.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028441.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2590"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1098024"/>
    <dbReference type="KEGG" id="sco:SCO2590"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2636"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003394_1_0_11"/>
    <dbReference type="OMA" id="FELYLFE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1197" mass="134973" checksum="D4B2072970248DC3" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IV2</accession>
    <name>Q93IV2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1318</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625604.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027716.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1318"/>
    <dbReference type="GeneID" id="1096741"/>
    <dbReference type="KEGG" id="sco:SCO1318"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1321"/>
    <dbReference type="HOGENOM" id="CLU_070075_0_0_11"/>
    <dbReference type="OMA" id="LKEKWCG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="33245" checksum="B595F20C86A32597" modified="2001-12-01" version="1">MWPGEQSSTGGPDPRHPNPYRQPGYQQQPHPGQQQPAPWNAPAVASGGPAGGPAGGPAGRGPGHGRTKVVVIVAAAVVVVAAAVTGAVLLGGGEDDGARPGPTASAPSVSAPSASPADDPRGGDGAPKATVEGWTVVANPDLGLAFDVPASWVPQSRDWVTYVAEDDDPDEKPLVAMKAPAVLKEKWCGSDGDRDGSVEYTPLASAGTRGNNGARSTGEIARADSATWVYGAFAQPDRDKVSTGTVTPFTTDSGIEGSLATSRSAGVAKKGKCDVNGKATTFAFKSADGDFVSWSFFGAAGVADEVTDATVRRILATVREYTPSDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J03</accession>
    <name>Q93J03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO7517</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631562.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031716.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102955"/>
    <dbReference type="KEGG" id="sco:SCO7517"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7631"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050656_1_0_11"/>
    <dbReference type="InParanoid" id="Q93J03"/>
    <dbReference type="OMA" id="SLHGWLW"/>
    <dbReference type="PhylomeDB" id="Q93J03"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="9">
        <location>
            <begin position="83"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="432" mass="43517" checksum="DC222112875091B7" modified="2001-12-01" version="1">MTTASPAGPSPAAPPRPSTPLFAPSPTSSARPEAPPLPPVRRTPLAVSGLLAVALTAYVWSAHGAKPGVLLLLGLGLGLALFHSRFGFTSAWRQLVAVGNGTGLRAHALLLGTTATLFALVIGTESGLFGSQPAPSAGPIGVGLFAGSALFAIGMQLGGACASGTLFAVGSGQTSIVLTLGGFVAGATLAAWQFDLWKDLPAWEPVVLSEHLGWFGSWAVTVAALLLVVLVSRRIQARRNPPPLGAVPSARRAVVRAVRGSWPLAVGALALALLGAGVLLVSGGAWGVTSAFSLWGSELVGALGGHPENWTWWQRPGNAEMLAGPVLADKTSLTDIGIMIGAAVAASLGGTWALHRGIPWRTAVAAVLGGVLMGIGARLAGGCNIGAYLAGIASGSLSGWLWGAFALAGTWVGLKLRPLFGLGNPKPGDGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J82</accession>
    <name>Q93J82_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2815</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627044.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028600.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2815"/>
    <dbReference type="GeneID" id="1098249"/>
    <dbReference type="KEGG" id="sco:SCO2815"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2873"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107158_0_0_11"/>
    <dbReference type="OMA" id="HLLMTGW"/>
    <dbReference type="PhylomeDB" id="Q93J82"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="232" mass="24095" checksum="4953CDBF846B8855" modified="2001-12-01" version="1">MRPNCMGKCPNPAIPGTIHGVEPSRGDRSGTNERPMAPRGVATPDVRERLFAAAERIVERDGPGALTSRAVTTEAGCAKGLLHAHFAGFDEFVAELCLDRFAKTATKARALSGIAGQGAVEHNLNTVALALFDSGGLALSGLAMTRPAAALGIREALEKGAPGFTAIQDAIADYLEAERELGRVARTVDPPSVALAVVGTAHHLLMTGRPDAPDPRPLVTRLIATLVNAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JB1</accession>
    <name>Q93JB1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7485</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631532.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031695.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7485"/>
    <dbReference type="GeneID" id="1102923"/>
    <dbReference type="KEGG" id="sco:SCO7485"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7597"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214224_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JB1"/>
    <dbReference type="OMA" id="VLTKRYH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="24150" checksum="F9E1A2EB8210550D" modified="2001-12-01" version="1">MTASPHDRLPPFPADRRETFADRNAVTADPAPWTDRPVEVGLVGAGPWARAMHARVLAAGPETRLAAVWARRTEAARETAAPYGAHVAADFEELLDHCEAVAFAVPPAVQAELAPLAAKRGKDLLLEKPLGPDLAAARRVADAVAESGVVSQLVLTKRYHPATRAFLEAARSFEAVGARSCYLHGAFLGGDFATGWRLEHGALLDLGPHLLDLLDAAVGPPASTRTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q99PX4</accession>
    <name>Q99PX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.288c</name>
        <name evidence="1" type="ordered locus">SCP1.65</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639640.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639898.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039366.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095144"/>
    <dbReference type="GeneID" id="1095371"/>
    <dbReference type="KEGG" id="sco:SCP1.288c"/>
    <dbReference type="KEGG" id="sco:SCP1.65"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8013"/>
    <dbReference type="HOGENOM" id="CLU_330354_0_0_11"/>
    <dbReference type="OMA" id="YPHLLAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="892" mass="98433" checksum="FFFAD703B93246CB" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QD8</accession>
    <name>Q99QD8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore associated protein, SapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sapC</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="1" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">A3</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">A3</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="1" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">A3</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="1" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">A3</strain>
            <plasmid evidence="2">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639631.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639907.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039357.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095135"/>
    <dbReference type="GeneID" id="1095380"/>
    <dbReference type="KEGG" id="sco:SCP1.297"/>
    <dbReference type="KEGG" id="sco:SCP1.56c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8004"/>
    <dbReference type="HOGENOM" id="CLU_1766921_0_0_11"/>
    <dbReference type="OMA" id="FCADEVM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045728">
        <property type="entry name" value="DUF6082"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19560">
        <property type="entry name" value="DUF6082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="150" mass="17206" checksum="62FB66BD75EC1994" modified="2001-06-01" version="1">MKLHHATALAVAAVGTAHLVLRERHRWQQNEIAVMRNQLDWLTHLTTHPEFAQIWAPKDMAVEEYIKLLHVNQQICALSLRHRLGLLRGRRLRFCADEVMKREYGLKYWAAYGSLREAESDGDGLAGDFTDVMHAAYTRATRNSSGTERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACT4</accession>
    <name>Q9ACT4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCP1.217Ac</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639825.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039517.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095297"/>
    <dbReference type="KEGG" id="sco:SCP1.217Ac"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8159"/>
    <dbReference type="HOGENOM" id="CLU_063871_0_0_11"/>
    <dbReference type="OMA" id="DGPNLAC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323003" evidence="2">
        <location>
            <begin position="36"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="381" mass="40037" checksum="45B3D68D962B7525" modified="2001-06-01" version="1">MPSFPAGGHVIVFVCAGCGAELTAPLSQVALPAHAHQKYGNGVQLPVLMEPGTFAVESESESWRPSWPSWEKGAPDAADGPGIHASADGLLSGDAADSSVIAPGDTRGTVLIPEKSGGYCCGLDGADGPNMACEVCGLPVASRIEDCSLWQAVWLAPNTVRRHAIGDASPAPLPWADLTAGAMGTPPYEPITSWGGRHFGLYHRWSWSPRWEAAAGRGLAHLLAASGGRPVSVPHGLTAEVFQRALDALLSADGPPLHAALAGPNLPAPDTDADLLLVPEHPQTGETWAPAGGTLAYLVPLPLGVWLWLAFPEPHLPADPPPQVLPAELLRDDPLSPRPGHLFRIDAGVFRHTLLRLPAAGDPWLREVLENLPTYARTGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACY5</accession>
    <name>Q9ACY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.166</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639739.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039465.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095244"/>
    <dbReference type="KEGG" id="sco:SCP1.166"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8112"/>
    <dbReference type="HOGENOM" id="CLU_071262_0_0_11"/>
    <dbReference type="OMA" id="MCWTPEP"/>
    <dbReference type="PhylomeDB" id="Q9ACY5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325716" evidence="2">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="30764" checksum="C7E5B3C6B3EA32F6" modified="2001-06-01" version="1">MLKRHGIASAATAVLVALAVPFSAHADEDPRGGGSTDCLLFTCQVEVEVPGNAGGQAGGGDGAGKSGGNGSSASADNTDKRVCTYELADPQPPADSLDWEGHKPGDGAVYKQKCGWEGLDGNTIVRMVWMPEPPPEQETVDPAVLAQQAVDKMTLLGPDIGITPKPGGKGVVGMPVYMWTDKGAETYGPNTASASAGGLTVTATAKVKKIVWTMGDGNTVTCTTAGTPYKAAYGKEPSPDCGYRYTAPSSTSSTGKYHVTATSTWVVDWTVNGGGGQGGQLTEIRNSAVDITVAEVQVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD02</accession>
    <name>Q9AD02_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCP1.148</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639721.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039447.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C40.007"/>
    <dbReference type="GeneID" id="1095226"/>
    <dbReference type="KEGG" id="sco:SCP1.148"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8095"/>
    <dbReference type="HOGENOM" id="CLU_055280_1_0_11"/>
    <dbReference type="OMA" id="PNWATIP"/>
    <dbReference type="PhylomeDB" id="Q9AD02"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325717" evidence="2">
        <location>
            <begin position="29"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="255"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="384" mass="39678" checksum="3892BF8C52DAC57B" modified="2001-06-01" version="1">MNSGRSKWLASGVAGVCLLGVVATGAVAAHVAGVTEAQAQAAAARLQCQGPAGAVDTDTAQLAQQVSTLVSGSGDVQVPGLPAPKEQLPNAKIIVATGIQLGISARGQVVALATALQESALRNLDHGDRDSVGLFQQRPSMGWGTREQLMDPVYASKKFYNALQSVNGWESMPVTAAAQKVQKSGLPDAYAKYEQLATALQNAIAPTLGATITSPTGTVTNPYGLRCGTQPDGSQYGTIEAGKLPDGYQIPATAKPAAQAAIQWALQQLGTPYQWGGSCTDPHGDDPSGRCDCSSLMQRAYGVAGIQITRTTYTQIHDGRAAPANATSLQPGDLVFTEGSASRPEHVAMAIGDGLLVHAPRPGRVVEVAKVATHGDILVVRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADM8</accession>
    <name>Q9ADM8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4030</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628212.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4030"/>
    <dbReference type="GeneID" id="1099466"/>
    <dbReference type="KEGG" id="sco:SCO4030"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4093"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_11"/>
    <dbReference type="InParanoid" id="Q9ADM8"/>
    <dbReference type="OMA" id="FAMNYNQ"/>
    <dbReference type="PhylomeDB" id="Q9ADM8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="96"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="273" mass="28607" checksum="E981DD8754E3A138" modified="2001-06-01" version="1">MGLTARIRTRDGWAVSHAVVTVTDMTGTQVLRAEADTEGAVRDTTALTPGAYTVIVTAVGYAPAASSAIVTASGRAEVGTVTLARQGGTELPPPGPWTVDPAHSSVAAVAQHLGISSVRGRFTDFAATVEIAPDDVGKSRVEAVIKAASIDTGNGMRDTHLRSADFLDVERYPEITYRSTGVSEVGPDRWTVHGELGLHGVVREVDLDLAHLGTGADPWGGTRAAFRATTELHREDFAMNYNQVVQAGIAAIGTTLRVELDVQAVQGESLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN9</accession>
    <name>Q9ADN9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4018</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628200.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974945.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4018"/>
    <dbReference type="GeneID" id="1099454"/>
    <dbReference type="KEGG" id="sco:SCO4018"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4081"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_2_1_11"/>
    <dbReference type="InParanoid" id="Q9ADN9"/>
    <dbReference type="OMA" id="LAWDEVP"/>
    <dbReference type="PhylomeDB" id="Q9ADN9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="17927" checksum="1CF8DF41E8688741" modified="2001-06-01" version="1">MSANNPFARLPEAASFTVTSTTVADGAAWPSAQRSAGVPGGKDVSPQLSWSGAPEGTRSYAVTVYDPDAPTGSGFWHWAVADIPAAVTELPEGAGDDTGPGLPEGAFQLPNDARAARYIGAAPPAGHGPHRYFVVVHALDVESIGIPADATPAVLGFTMAGHILGRAVLTATAETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJY1</accession>
    <name>Q9AJY1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B12-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7749</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631785.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031881.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7749"/>
    <dbReference type="GeneID" id="1103187"/>
    <dbReference type="KEGG" id="sco:SCO7749"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7871"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069063_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AJY1"/>
    <dbReference type="OMA" id="WRVDFLG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="103"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="38974" checksum="689A71CB5A9AD332" modified="2001-06-01" version="1">MSTSTPPHIPHARDVQRAADQLWHAVTGGDEYAATEVVLRILDEGAAPESVLLDVIAPVQGRVGEEWAANRISVAQEHAATAINERAVAAVSVHPVVRTTATRGRIAVACVDGEWHALPARLLAEVLKLRGWQVDYFGAQVPTAHLIAHLHNARTDAVALSSSIATRLPTAHAAITACQAVGVPVLVGGAAFGPGGRYAVLLGADAWAANARAAADRLAQSPLPRPQPDHQQFDDLPHLADQEYTLVTRNSVTLVRTVFSVLEDAFPTMRSYSSDQRERTAEDLAHMVEFLATALYLDDEELFTGFLTWTAQILEARDVSARSLPPALKLLARELQDFPRAVRILKAATCALTTAPSTVAGTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJY5</accession>
    <name>Q9AJY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7743</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631781.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031877.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1103181"/>
    <dbReference type="KEGG" id="sco:SCO7743"/>
    <dbReference type="eggNOG" id="ENOG502ZICB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1642794_0_0_11"/>
    <dbReference type="OMA" id="DAWYLEL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="18261" checksum="38232641D6FEB59D" modified="2001-06-01" version="1">MVFRHPDGDYAITAIYSVPDDAWYLELDLVAGQRNLVTAIIPDEDPAREPTVCFNPSAGHTDVPYEVMRWFMHQVDEEIRSSRAWMRLRPELVETVYQLRQEHMGVIDDDDFPQVLADVRTTVPEEDLPAVLEAAFGRNPDGTTMNHPQTPQPVGDQGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK48</accession>
    <name>Q9AK48_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4878</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629031.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974094.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4878"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1100319"/>
    <dbReference type="KEGG" id="sco:SCO4878"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4958"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_11"/>
    <dbReference type="InParanoid" id="Q9AK48"/>
    <dbReference type="OMA" id="RTYCAII"/>
    <dbReference type="PhylomeDB" id="Q9AK48"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="326" mass="36399" checksum="6D2E7162DF7DCEF7" modified="2001-06-01" version="1">MPKLSVIVPFYNVRQYAPDTLRSLRANARDDFEFILVDDCSSDGTADLLARAESELPGAVLVRHERNGGLATARNTGIDRARGEYLTFLDGDDWLAPGYYERLLAAIEELGCDFVRTDHVQCTARARVVHRVPHGRRNVSLRPRDAILPAHRSTSVDYAYAWAGVYHRRLVDRGLLHFTDGLRTAEDRPWIWRLHREAESFAVTGLLGVFYRRGVASSLTQIGDVRQLDFIRAFDEVVAGAAEDADAARLLPKAVRTYCAIISHHLGSVERFEPAVARKLKAMSAAALRRMPQGALDEVLGSMDTERATLLRRLRRRGPQGAEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWD9</accession>
    <name>Q9EWD9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4868</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629022.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029915.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4868"/>
    <dbReference type="GeneID" id="1100309"/>
    <dbReference type="KEGG" id="sco:SCO4868"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4947"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055984_1_0_11"/>
    <dbReference type="OMA" id="YWKSRHH"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018104">
        <property type="term" value="P:peptidoglycan-protein cross-linking"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176635" evidence="4">
        <location>
            <begin position="31"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="168"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="30460" checksum="CEC3B937E74DD345" modified="2001-03-01" version="1">MRMTGMGSTGRVVAVALGAVLVAGGCTVQGTGPDGRGRAPVRIEVTGHPPKSTPAPDRHRPSSAPPAAPAAARVLWKRGDTGRDVRELQARLRQVEWLVDGPTGTYDDLTERAVSGFQGKRGLPRTGRTDTVTWQRLLGMSHEPGKWDLYLMGGQPAAAPDPRCTSGRVLCVSKSSRTLRWMIDGRTVSTMSVRFGSQYTPTREGVFQVYWKSRHHVSTLYDSAMPYAMFFSGGQAVHYSYDFAARGYAGASHGCVNVRDEAAIADLYAQVKTGDKVVVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWP5</accession>
    <name>Q9EWP5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative non-ribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7682</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631721.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031827.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7682"/>
    <dbReference type="GeneID" id="1103120"/>
    <dbReference type="KEGG" id="sco:SCO7682"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7803"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_8_11"/>
    <dbReference type="InParanoid" id="Q9EWP5"/>
    <dbReference type="OMA" id="LYQEFDG"/>
    <dbReference type="PhylomeDB" id="Q9EWP5"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2142"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1737"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1104"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC17499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="2229" mass="239297" checksum="66EB782247C326CD" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWR0</accession>
    <name>Q9EWR0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7667</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631706.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971478.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7667"/>
    <dbReference type="GeneID" id="1103105"/>
    <dbReference type="KEGG" id="sco:SCO7667"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7786"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070871_2_0_11"/>
    <dbReference type="InParanoid" id="Q9EWR0"/>
    <dbReference type="OMA" id="AGRGFEQ"/>
    <dbReference type="PhylomeDB" id="Q9EWR0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC17484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="20804" checksum="1FED6100E9C85C2E" modified="2001-03-01" version="1">MSLDALPVPGSPASAAALDVATAYLPPALLNHSLRAYVWAAARGTADGLTFDPELLYVAALHHDIGLVPAFDSHTVAFEEASGHVARVFAAGAGWPAERRERLADVIVRHMAPQVDAATDPEGHLLARATATEITGKGADDYPPCFRDEVLARYPRLDLTERFLACFQAQAARKPGSSAGGAVRSGLADRMAANPLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWY3</accession>
    <name>Q9EWY3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">SCO1143</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625436.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1143"/>
    <dbReference type="GeneID" id="1096566"/>
    <dbReference type="KEGG" id="sco:SCO1143"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1140"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_3_11"/>
    <dbReference type="InParanoid" id="Q9EWY3"/>
    <dbReference type="OMA" id="QRNAMNV"/>
    <dbReference type="PhylomeDB" id="Q9EWY3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="27145" checksum="813CE1C777ED9CB2" modified="2001-03-01" version="1">MAVPLLTTDDEGESRPASLLIPEGWRATQVYGAVDKALALPAGTTKKSLAKANLKLPNDAEGNPEGYLFPATYPLGENPTPEKLLTAMVDTANKKFTGAPVAAGAQRNALNVYQAVTIASIVQAEAAAKEDMGKVARVIFNRLERGMPLQMDSTINYALGRSTLKTSTKDTKIDSPYNSYQRMGLPPTPIANPGDEAMTAAINPTPGDWLYFVTVKPGDTRFTADYTEHRRNVDEFNRLQQSASKQAGAGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX44</accession>
    <name>Q9EX44_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0994</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027503.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0994"/>
    <dbReference type="GeneID" id="1096417"/>
    <dbReference type="KEGG" id="sco:SCO0994"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.992"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650384_0_0_11"/>
    <dbReference type="InParanoid" id="Q9EX44"/>
    <dbReference type="OMA" id="SVFLHER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC14362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="421" mass="43822" checksum="A0B747AFF09EA6FF" modified="2001-03-01" version="1">MAEHAPGGSGLRAALSTLDGPPRFLLLSSFLIPLGSFMILPFMSVFLHERLGMGLGTVGIVLAVASLVQFSGGIVGGALADRIGLRRTMLWALIIRTAGFIGLLLALRWPPLAVAALVLTCCGAALYLPANKAYLVHGVDDERRPAFLSAGNAALNAGMAVGPLIAGPFVLSSPGWLFVAVTALFVLVTVGHARLPPAGGARKSGGQGAAQSLLAGVAVLPFAANALAFYLYFHFQHYLAVYAVERASSTFYSLVLLLCFTLVIVVQPLASGLIRRMPYATALTVGFTGLAAGLAVLAIGTRTALLAGGALITLGDIVLFLKNDLEALHRSPRSDAVVFGQQRLAAGLGACASGVLGGQLYSLTEQAGNTGWFWLMAAAQCLVLPPVLLALRKRPAQHPHPHHDDEGALRPHGTNGRVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2K4</accession>
    <name>Q9F2K4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3777</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627967.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029228.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3777"/>
    <dbReference type="GeneID" id="1099213"/>
    <dbReference type="KEGG" id="sco:SCO3777"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3837"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_11"/>
    <dbReference type="InParanoid" id="Q9F2K4"/>
    <dbReference type="OMA" id="IHEWPYL"/>
    <dbReference type="PhylomeDB" id="Q9F2K4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
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    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="158"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC10315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="375" mass="39890" checksum="16ACAD48978CE23A" modified="2001-03-01" version="1">MGDAAPGAFTDEVYAARMDRTAYQAAALGLAGVLVTPGPDLVWLCGYRPTAPIERLTLLVLTATSQPRLLVPALDRPTAEASPGAGAVRVSDWWEGQDAYAAAAGLLRPHGRYAVSDATWALHLLCLQASLPLATYQPLSVVLPMRRAVKDEQEMARLTAAAAAADTAYEEVLGLRFGGRSERELAADLAGLLRAHGHSRVDFTVVGAGPHAADPHHRPGDRVIGDGDMVVLDFGGLKDGYGFDIARTVHVGAPTDEERRVHETVRAAQRAAFGAVRPGVSCQEVDRAARAVIEEAGHAGHGARRTGHGVGVTTHEPPYLVEGEEQPLEPGMCFSLEPGIHLPDRFGVRIEDVVTCTEDGGRRLNTTSHELAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2M9</accession>
    <name>Q9F2M9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3121</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627339.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028782.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3121"/>
    <dbReference type="GeneID" id="1098555"/>
    <dbReference type="KEGG" id="sco:SCO3121"/>
    <dbReference type="HOGENOM" id="CLU_3258234_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC09562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="42" mass="4530" checksum="E41DB317B4B9E329" modified="2001-03-01" version="1">MRKNAGDSSRGCLAIKVLKSADLYRRIEGSWYGIVLGADSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Q5</accession>
    <name>Q9F2Q5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3094</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627312.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028762.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3094"/>
    <dbReference type="GeneID" id="1098528"/>
    <dbReference type="KEGG" id="sco:SCO3094"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3156"/>
    <dbReference type="eggNOG" id="COG1507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097805_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2Q5"/>
    <dbReference type="OMA" id="IAHRCPC"/>
    <dbReference type="PhylomeDB" id="Q9F2Q5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC09535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="186" mass="20142" checksum="EE2913F5249603FD" modified="2001-03-01" version="1">MQTPPPTTPRTEPTDADVAAFKQQLGRPPRGLRAIAHRCPCGQPDVVETAPRLPDGTPFPTLYYLTCPKAASAIGTLEANGVMKEMTERLATDPELAAAYRAAHEDYIRRRDEIEELTGFPSAGGMPDRVKCLHVLVAHSLAAGPGVNPLGDEAIAMLPEWWRKGPCVTPTEQTDETDETGQEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3B6</accession>
    <name>Q9F3B6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7559</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631602.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031745.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F3B6"/>
    <dbReference type="STRING" id="100226.SCO7559"/>
    <dbReference type="CAZy" id="GH64">
        <property type="family name" value="Glycoside Hydrolase Family 64"/>
    </dbReference>
    <dbReference type="GeneID" id="1102997"/>
    <dbReference type="KEGG" id="sco:SCO7559"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7673"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032886_1_1_11"/>
    <dbReference type="InParanoid" id="Q9F3B6"/>
    <dbReference type="OMA" id="SFQKPDA"/>
    <dbReference type="PhylomeDB" id="Q9F3B6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="entry name" value="PTHR38165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176676" evidence="1">
        <location>
            <begin position="34"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_64" evidence="2">
        <location>
            <begin position="38"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="398" mass="42441" checksum="ECCF02ACE68A3DFE" modified="2001-03-01" version="1">MLSRLRHRLLAVAAAAGLTGALLSFGAAPPADAAVPATIPLKITNNSARGDAVHIYNLGTSLTTGQQGWADENGTFHAWPAGGNPPTPAPDASIPGPAAGQTKTIRIPKLSGRIYFSYGQKLDFRLTTGGLVQPAVQNPSDPNRNILFNWSEYTLNDGGLWLNSTQVDMFSAPYTVGVQRADGGVTSAGQLKAGGYRGVFDALRAQPGWGGLIQTRPDGTVLRALAPLYGVETGALPASVMDDYINRVWQKYTTTTLTVTPFGDRPDTKYFGRVSGNVMNFTNTSGAVVTSFQKPDASSVFGCHRLLDAPNDQVRGPISRTLCAGFNRSTLLSNPNQPDPSAANFYRDPVTNHYARIIHERMADGKAYAFAFDDVGNHESLVHDGNPAEARLTLAPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3G0</accession>
    <name>Q9F3G0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4540</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628703.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029718.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4540"/>
    <dbReference type="GeneID" id="1099980"/>
    <dbReference type="KEGG" id="sco:SCO4540"/>
    <dbReference type="HOGENOM" id="CLU_2588099_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="80" mass="8866" checksum="4677CF398A80F3C2" modified="2001-03-01" version="1">MSAGPDVLDPEGQLLTGIGSLYTDGEWIWRGDLSYYVSHHHVALPDQFVTHIRDSNYSPPKVPENRLVAIATEDLGMSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3M4</accession>
    <name>Q9F3M4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7664</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631704.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031813.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7664"/>
    <dbReference type="GeneID" id="1103102"/>
    <dbReference type="KEGG" id="sco:SCO7664"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7783"/>
    <dbReference type="eggNOG" id="COG5483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_0_1_11"/>
    <dbReference type="InParanoid" id="Q9F3M4"/>
    <dbReference type="OMA" id="RHNPQFN"/>
    <dbReference type="PhylomeDB" id="Q9F3M4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC16997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="20164" checksum="C90C50E16C846DF3" modified="2001-03-01" version="1">MSRVHTIGHSTRAFDEVLDMLRGHDITCLVDVRSYPSSRKHPQWNQSAVVENLPPDIEYRWISRLGGRRHTPKGVPSENGAWRVKAFRDYADYMAGDEFAEGLDELIGLARHERPAIMCSEAVPWRCHRRLITDALLVAGVEVVHIMSRTATKPAVLNEHARVRDGHLTYPPPDAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBQ8</accession>
    <name>Q9FBQ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5288</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC04503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629433.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030154.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5288"/>
    <dbReference type="GeneID" id="1100729"/>
    <dbReference type="KEGG" id="sco:SCO5288"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5373"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067299_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBQ8"/>
    <dbReference type="OMA" id="PWFTARL"/>
    <dbReference type="PhylomeDB" id="Q9FBQ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="27468" checksum="AC78A733CF385ACA" modified="2001-03-01" version="1">MRTELVSEPGLADQPNEDFASVGLPASGQGGSLVVLDGVTPPRTATGCLHSVPWFTARLGGALTELTVSLPDLPLAEALSRGIARTAAAHAETCDLSHPRTPQATVVLARWSAAAFEYLVLSDSALLLEAPDGTLTPVLDDRLARLPRSALVSDAVIDAGLRNKEGGFFTAAADPAVAARAVTGVLPRGAVRTLAALTDGAARWVEKFGEGDWADCLALVRKQGAQALVDRVRELERADAADGRAFLGRSKTHDDATVVYAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBT7</accession>
    <name>Q9FBT7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7155</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631214.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031466.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7155"/>
    <dbReference type="GeneID" id="1102593"/>
    <dbReference type="KEGG" id="sco:SCO7155"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7256"/>
    <dbReference type="eggNOG" id="COG3369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043311_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBT7"/>
    <dbReference type="OMA" id="TALYSIK"/>
    <dbReference type="PhylomeDB" id="Q9FBT7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="38440" checksum="7D33755A457D207E" modified="2001-03-01" version="1">MSQDQTDTLDPASAAGIATLDDLRRHLQWAIEVEHSTLPPYLTALYSLDPERNADAVQLISGVFVEEMIHLALAANLLNAVGGRPVLDAPHLLPPHPRTMPHADPSIELSLLPFGQEALRLFLRLEQPARPGDPAEGDHYETIGQFYDAIERGLRHLCAELGEDQVFVGDPARQVAGGPFVHTAGHLAPVTDLSSALAALEEIVEQGEGAARAEVWDGDKDMFHPGTRAVSHYYRFQELALGRRYQTGDTPDSGPTGEAVTVDEAGIRPVRPNPRLADHPEGSAIRAAQEVFNQTYCKTLEMVEQAFNGNPAMLGMSVGTMYALKAQAQGLMALQDDDGQAAGPTFEYVAPEDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH4</accession>
    <name>Q9FCH4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4195</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628370.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029494.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4195"/>
    <dbReference type="GeneID" id="1099635"/>
    <dbReference type="KEGG" id="sco:SCO4195"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4259"/>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010312_3_0_11"/>
    <dbReference type="InParanoid" id="Q9FCH4"/>
    <dbReference type="OMA" id="KHDARMA"/>
    <dbReference type="PhylomeDB" id="Q9FCH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033202">
        <property type="term" value="C:DNA helicase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC04031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="680" mass="72790" checksum="5E7A9C787B1A169F" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCH9</accession>
    <name>Q9FCH9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4190</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628365.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974781.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4190"/>
    <dbReference type="GeneID" id="1099630"/>
    <dbReference type="KEGG" id="sco:SCO4190"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4254"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078241_0_0_11"/>
    <dbReference type="OMA" id="QKWFDAL"/>
    <dbReference type="PhylomeDB" id="Q9FCH9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC04026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="32999" checksum="EFB88DC9FD9438C1" modified="2001-03-01" version="1">MVVTQENVSVNGSRRLSSQEIADVLRERIRGGDLRAGDRLPTQAELAEEFGVERGTVRQALRALQEDGLLTNVSKGSPPRIAEPATPRAEPQPTMVALGPRLAEAFAAPHVRVDVVCHTSETLMLALSEPLRLIHEGRIHPESIDFRVLMPSRDIALAFPVLVEDEEDDPVHQRWLQMRNAQARVLQHNLHAVRSTHRVDVRIAFRALPFTPPMKLYLLNGEEALLGYYMLTRREEEYESRTLQMYDALGSQSLLFSFLNRTGHRDAVFVEESQKWFDALWETITTDMTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M0</accession>
    <name>Q9K3M0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1040</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625335.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027536.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1040"/>
    <dbReference type="DNASU" id="1096463"/>
    <dbReference type="GeneID" id="1096463"/>
    <dbReference type="KEGG" id="sco:SCO1040"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1035"/>
    <dbReference type="eggNOG" id="COG3145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039677_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K3M0"/>
    <dbReference type="OMA" id="NCGPLGW"/>
    <dbReference type="PhylomeDB" id="Q9K3M0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB96025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="23424" checksum="15153ACD08419CCA" modified="2000-10-01" version="1">MDAELFPRTRAETAPGAVHLPDWLSPGQQRELLDACREWARPPAGLRTVRTPGGGTMTARQVCLGRHWYPYGYAATAVDGDGAPVKPFPARLDGLARRAVTDALGAEAVAPAPYDIALINFYDADARMGMHRDADERTDAPVVSLSLGDTCVFRFGNPETRTRPYTDTELRSGDLFVFGGPSRLAYHGVPRVHPGTAPPELGLRGRLNITLRVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M6</accession>
    <name>Q9K3M6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1034</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625329.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027532.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1034"/>
    <dbReference type="GeneID" id="1096457"/>
    <dbReference type="KEGG" id="sco:SCO1034"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1029"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_11"/>
    <dbReference type="InParanoid" id="Q9K3M6"/>
    <dbReference type="OMA" id="MYHHFKG"/>
    <dbReference type="PhylomeDB" id="Q9K3M6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB96019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="217" mass="23379" checksum="80905A90A0DF646A" modified="2000-10-01" version="1">MGSTAPARVCFPPLLFARSTSVTTSMYSACMNTSERLIESTRELLWERGYVGTSPKAILERADAGQGSMYHHFKGKPDLALAAIRRTAEEMRAAAGAVLAGPGTPYERIEAYLRRERDVLRGCPVGRLTMDPDVIADDTLRAPVDETLDWLREQIAQLVEEGREQGEFAPSLDGEEIAAAVVATVQGGYVLARASGSPAAFDAGVRGLLSLLATHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Q5</accession>
    <name>Q9K3Q5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1093</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625387.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027569.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1093"/>
    <dbReference type="GeneID" id="1096516"/>
    <dbReference type="KEGG" id="sco:SCO1093"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1090"/>
    <dbReference type="eggNOG" id="COG3324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069623_3_0_11"/>
    <dbReference type="InParanoid" id="Q9K3Q5"/>
    <dbReference type="OMA" id="TTVFGWS"/>
    <dbReference type="PhylomeDB" id="Q9K3Q5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="167"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="30215" checksum="EDC296C5ED710FE1" modified="2000-10-01" version="1">MPDGRGPGPALACWRGTDGLRPRRKDASTMKLHEPVTGGPCWAELGTTDLEAAKRFYTKLFGWRPETDPRQRAGGYTIARIDDAPVAALTPLYQQGQPVAWNVSFAVRDADAAARQVTAAGGVALQGPADVFDAGRFAVAADPTGAVFQLWQGRSFPGAGLFNAPGSLGWVELLTREPGRAADFYTTVFGWSVGASDRYPQWGIDGADFGGMVTMDDKFPHEVPAHWLPYFAVADVNTVAVDTTDGGGTVLMEPTSVPDGPRIAVLRDPQGAMFGVYRAGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3V5</accession>
    <name>Q9K3V5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4389</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628558.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029625.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4389"/>
    <dbReference type="GeneID" id="1099829"/>
    <dbReference type="KEGG" id="sco:SCO4389"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4457"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000840_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="31451" checksum="770D691602F59748" modified="2000-10-01" version="1">MTKRLGEAPVRRAVVSGSTFEERIGYARAVVDGDWVHVSGTTGFDYATMTISGDVVEQAEQCLHNIATALAEAGCTFADVVRVRYLLPAREDFEPCWPVLRRAFGQVRPAATMMVCGLADERMRIEIEVYARRGAVATGAGPALRIEPVAGDAMVEEWRHVHNVIVPPAAMTPDEARERAGRNRLANAYLADVLVGCSTVRPPGGEERVATVIARTLPAYRGRGIGTALYEEGLAHARVLGAEAVETVVLAANADGLRFAGARGFAEKERYVLDGEHDEWVDLRLAAARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K417</accession>
    <name>Q9K417_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1082</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625376.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027565.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1082"/>
    <dbReference type="GeneID" id="1096505"/>
    <dbReference type="KEGG" id="sco:SCO1082"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1079"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K417"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="PhylomeDB" id="Q9K417"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB95301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="27750" checksum="A4BBF1A301F1CBAF" modified="2000-10-01" version="1">MSLRIVVTVKYVPDATGDRHFADDLTVDRDDVDGLLSELDEYAVEQALQISENSDDDVEVTVLTVGPEDAKDALRKALSMGADKAIHVEDDDLHGTDAIGTSLVLAKAVEKAGYDLVVSGMASTDGTMGVVPALLAERLGVPQVTLLSEVSVEGGVVKGRRDGDSATEQLEASLPAVVSVTDQSGEARYPSFKGIMAAKKKPVQSWDLSDLDIDEDEVGLENAYTVVESATERPARTAGTIVKDEGEGGKQLAEFLAGQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXS9</accession>
    <name>Q9KXS9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4312</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628484.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029572.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4312"/>
    <dbReference type="GeneID" id="1099752"/>
    <dbReference type="KEGG" id="sco:SCO4312"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4380"/>
    <dbReference type="eggNOG" id="COG4339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051795_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KXS9"/>
    <dbReference type="OMA" id="PQRRYHT"/>
    <dbReference type="PhylomeDB" id="Q9KXS9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="28580" checksum="28ECDE189E0E796E" modified="2000-10-01" version="1">MVRPPPFEFRPARPPGTRALQLEVITNIIWENAPMADLDALRSRFAHALAGATAPGATAGAGPGSGPDPAPYADNLLARWQEPQRRYHTLAHLTAVLDRVDVLAEHADDVAVVRLAAWFHDAVYQPDRSENEERSARLAERALPEAGVPAAKTAEVARLVRLTVTHAPAGDDRDGQVLCDADLAVLASPPSAYAAYTAAVREEYHFVPNEAFREGRAAILRQLLDLPSLFHTPYGRQEWEATARHNLTGELEMLSLPDTPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYC9</accession>
    <name>Q9KYC9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6901</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630970.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031286.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6901"/>
    <dbReference type="GeneID" id="1102340"/>
    <dbReference type="KEGG" id="sco:SCO6901"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7011"/>
    <dbReference type="eggNOG" id="ENOG503211N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079637_0_0_11"/>
    <dbReference type="OMA" id="FGPPAWG"/>
    <dbReference type="PhylomeDB" id="Q9KYC9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="155"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="288" mass="31671" checksum="D363DB86385F8338" modified="2000-10-01" version="1">MPHDDHDTIDGDVYVAPRHLARSTAVSDPGLDPLRDLGWDLHHDHLGNAYLTAPDGKLRLGYLPEGDDDGLWRINAYKDAFGPPAWGVCFNDSAPTEFVTAFTTALAEAYRQGPDRYLARPLAGSTDRDPFQAVDPLINRGWCFDRPDLRTFAITSPDGLATLEYTTGDLDPAIELETRDARWHLWAGTSSARPYWYATASTDTPAALLRAVTEAVADPAPLPRWRDDTPSYVKDHAQTSPIHPPSPPTPTPLDVRRAAASRRPAALPAASVPRWSTTSRHALPGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYZ6</accession>
    <name>Q9KYZ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7533</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631577.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971612.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7533"/>
    <dbReference type="GeneID" id="1102971"/>
    <dbReference type="KEGG" id="sco:SCO7533"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7647"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_11"/>
    <dbReference type="InParanoid" id="Q9KYZ6"/>
    <dbReference type="OMA" id="NISTIWG"/>
    <dbReference type="PhylomeDB" id="Q9KYZ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
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        <property type="entry name" value="WalR-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB90891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25754" checksum="BD02166C657AF05C" modified="2000-10-01" version="1">MARVLLIEDDPAVQRGVSLALKRRGHEVAVAGSGETGLLTLERHRPDLVLLDLMLPNMSGLEVCRRIRESKRIPIIILSARGDEIDMVVGLEAGADDYIVKPAGAELLEARIRAVLRRVAPAQDGGSRDPADAGPERHADLTVDRTTLVVAKHGTELPLAPSELKLLLFLTATPGQVYSRQQLLEQVWEHSFYGDVRLVDACVMRLRARIEDDPRKPVYVQTVRGFGYRFGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ68</accession>
    <name>Q9KZ68_STRCO</name>
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        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627300.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028756.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3080"/>
    <dbReference type="GeneID" id="1098513"/>
    <dbReference type="KEGG" id="sco:SCO3080"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3141"/>
    <dbReference type="eggNOG" id="ENOG5033TGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891134_0_0_11"/>
    <dbReference type="OMA" id="YTLTFAC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="28079" checksum="37714E68D54463D7" modified="2000-10-01" version="1">MSAMPIALLLTTAATGAVGVAVLRSILVLRRQVTALRAELAESRATATRGRVPAARTTADAEEIRAAVAEALAEERERELAEARAFWAAQETRDASDAPLLLGLSDSELFLPRQADLVGLEPVTEPAADADEPAAQDAGHTGPRESAELAAARRRHPSHPDFVPNPSPAVNDHDRTVATLEGLAESSVALADVRPGPLGTLDVYVFADGTTLCMTPGHRETAERLAAALGAGQTPYLLGGSGISGAYTLTFACGEENVYILADRVIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZD5</accession>
    <name>Q9KZD5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable NADH dehydrogenase I complex, subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO6954</name>
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    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631020.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031336.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6954"/>
    <dbReference type="GeneID" id="1102392"/>
    <dbReference type="KEGG" id="sco:SCO6954"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7054"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KZD5"/>
    <dbReference type="OMA" id="AFILQYM"/>
    <dbReference type="PhylomeDB" id="Q9KZD5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025607599" evidence="9">
        <location>
            <begin position="42"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB89015.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="967" mass="101771" checksum="A727564D3EEE05AC" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZL8</accession>
    <name>Q9KZL8_STRCO</name>
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        <recommendedName>
            <fullName evidence="2">bact-PGI_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">SCO3026</name>
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    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
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        <text evidence="1">Belongs to the PGI/PMI family.</text>
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    <dbReference type="OMA" id="QAYRRGC"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="375" mass="38230" checksum="74DDA6B9661D716E" modified="2000-10-01" version="1">MLDESLLDAPERLTQADRRGLLRGAAEAGARVRTAARHAAEAGVGNLKPDGRPRAVLIAGPGAAATHAADLLGTLAGAGSPVTRLAPTGVAPAAGALRWELPGWAGSVDLLLIATPDGAEPGLSLLAEQAYRRGCTVVAVAPARSPLNDAVSASRGLFIPMATAPYDHDEPLAGAAPGVLWALLTPLLALLDRTGLLEAPPEAIDKVADRLDQIAERCGPAIVTYSNPAKTLASELAETLPVVWTEGTSAGPAGRRFAAALAELAGTPAVVADLPEALAAHNALLAGRLAAGADPDDFFRDRVDEPPALHARVVLLRDRPSGGLTAAPNARDLALGHDTPISELEPEEGGELETLAELIAITDFAAVYLALASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZW3</accession>
    <name>Q9KZW3_STRCO</name>
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        <submittedName>
            <fullName evidence="7">Phosphate transport protein</fullName>
        </submittedName>
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    </gene>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628315.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029459.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4138"/>
    <dbReference type="TCDB" id="2.A.20.1.5">
        <property type="family name" value="the inorganic phosphate transporter (pit) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1099578"/>
    <dbReference type="KEGG" id="sco:SCO4138"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4202"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZW3"/>
    <dbReference type="OMA" id="RANPHKA"/>
    <dbReference type="PhylomeDB" id="Q9KZW3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="34899" checksum="490F3438A4A9738B" modified="2000-10-01" version="1">MDTFALVVTIGVALFFTYTNGFHDSANAIATSVSTRALTPRAALAMAAVMNLAGAFMGSGVAKTVSEGVIETPEGSKGMGILFAALVGAIVWNLITWYFGLPSSSSHALFGGMVGAALAGSTTVYWHGVVDKIVIPMFVSPVIGLLAGYLVMTAIMWIFRRANPHKAKRGFRIAQTVSAAGMALGHGLQDAQKTMGIVVMALVIADVEDYGDPIPVWVKLACALMLSLGTYAGGWRIMRTLGRKIIELDPPQGFAAETTGASIMFGSAFIFHAPISTTHVITSAIMGVGATRRVNAVRWGVAKNIIMGWFITMPAAAVVAAVSFWIVNLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L010</accession>
    <name>Q9L010_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2303</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626551.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976510.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1097737"/>
    <dbReference type="KEGG" id="sco:SCO2303"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2340"/>
    <dbReference type="eggNOG" id="ENOG5031X28">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209892_1_0_11"/>
    <dbReference type="OMA" id="GKHRGPV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="55" mass="5700" checksum="A0BE63F7AFE3C20F" modified="2000-10-01" version="1">MNDASTTQPMQAAGADVSETDTGHGKHRGPVSSQEGVVTPQGRHRKPAEESKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L096</accession>
    <name>Q9L096_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative serine/threonine protein kinase (Regulator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2450</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626693.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028360.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2450"/>
    <dbReference type="GeneID" id="1097884"/>
    <dbReference type="KEGG" id="sco:SCO2450"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2492"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005743_0_0_11"/>
    <dbReference type="OMA" id="CMGPQWR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="588"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1349" mass="145672" checksum="F0902A235D694B38" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0D0</accession>
    <name>RL14_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">SCO4712</name>
        <name type="ORF">SCD31.37</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628871.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974257.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0D0"/>
    <dbReference type="SMR" id="Q9L0D0"/>
    <dbReference type="STRING" id="100226.SCO4712"/>
    <dbReference type="GeneID" id="1100153"/>
    <dbReference type="GeneID" id="66855990"/>
    <dbReference type="KEGG" id="sco:SCO4712"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4783"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L0D0"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="PhylomeDB" id="Q9L0D0"/>
    <dbReference type="PRO" id="PR:Q9L0D0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000266568" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="122" mass="13370" checksum="49705967D7024784" modified="2000-10-01" version="1">MIQQESRLRVADNTGAKEILTIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVIVRTVKERRRPDGSYIRFDENAAVILKNDGDPRGTRIFGPVGRELREKKFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Q9</accession>
    <name>Q9L0Q9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional factor regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4232</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628406.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003953493.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4232"/>
    <dbReference type="GeneID" id="1099672"/>
    <dbReference type="GeneID" id="63981650"/>
    <dbReference type="GeneID" id="67401070"/>
    <dbReference type="KEGG" id="sco:SCO4232"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4294"/>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048259_1_2_11"/>
    <dbReference type="InParanoid" id="Q9L0Q9"/>
    <dbReference type="OMA" id="DMKVMIP"/>
    <dbReference type="PhylomeDB" id="Q9L0Q9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015968">
        <property type="term" value="P:stringent response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="17829" checksum="0D8F10F093DB8DAB" modified="2000-10-01" version="1">MTFKVGDTVVYPHHGAALIEAIETRQIKGVDKTYLVLKVAQGDLTVRVPADNAEFVGVRDVVGQDGLDRVFEVLRAPYAEEPTNWSRRYKANLEKLASGDVIKVAEVVRDLWRRERERGLSAGEKRMLAKARQILVSELALAENTNEDKAEALLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0R2</accession>
    <name>Q9L0R2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4229</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628403.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974746.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L0R2"/>
    <dbReference type="STRING" id="100226.SCO4229"/>
    <dbReference type="GeneID" id="1099669"/>
    <dbReference type="KEGG" id="sco:SCO4229"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4291"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_11"/>
    <dbReference type="InParanoid" id="Q9L0R2"/>
    <dbReference type="OMA" id="AMLAFRW"/>
    <dbReference type="PhylomeDB" id="Q9L0R2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="162"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB77323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="426" mass="45364" checksum="72E490310514F76C" modified="2000-10-01" version="1">MDVNAAVAAVAAIAGVLTGVIAVLAFRWSEREQKRPTRTSLHTDPVLPPGVDTVLSVLRSSAVVLDEADAVVKASSAAYALGLVRGGRLAVEPMLQMARDTRRDGEIRQVELDLPRRGNGRGEALAVSARVAPLGSRLVLLLVEDLTEARRIEAVRRDFVANVSHELKTPVGALSLLSEAVMDAADDPEAVERFAGRMQIEATRLTNLVQELIDLSRVQNDDPLDDAEPVRVDELVAEAIDRCRHAAGTKQITMAAGGTADLHVRGNRGQLAAALGNLVENAVNYSPARTRVGIAARRVAAPGGDLIEIAVTDQGIGISEKDKERVFERFYRVDPARSRATGGTGLGLAIVKHVVASHGGEVTVWSAEGQGSTFTLRLPEAGLARDRAQRRSDRAGLSAETERSSSAPQSPHTAPFETFPAPEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L147</accession>
    <name>Q9L147_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative pyruvate dehydrogenase (Pyruvate oxidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7412</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631461.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031645.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7412"/>
    <dbReference type="GeneID" id="1102850"/>
    <dbReference type="KEGG" id="sco:SCO7412"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7522"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_11"/>
    <dbReference type="InParanoid" id="Q9L147"/>
    <dbReference type="OMA" id="MITVKRY"/>
    <dbReference type="PhylomeDB" id="Q9L147"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="388"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="600" mass="65282" checksum="A5D0DA8382B7D90F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L148</accession>
    <name>Q9L148_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative LacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7411</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631460.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031644.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7411"/>
    <dbReference type="GeneID" id="1102849"/>
    <dbReference type="KEGG" id="sco:SCO7411"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7521"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9L148"/>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="PhylomeDB" id="Q9L148"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB76330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="352" mass="37544" checksum="DD5D3F5C2C07C149" modified="2000-10-01" version="1">MSTAEEVPTSAPAPPRRGRDRTASMADVARLAGVSSQTVSRVSNGYAGVTEETRQQVLAAMKELGYRPNSAARALKRGEFRTIGVITFTLATTGNVRTLEAIATSAASEGYAVTLLPVAVPTQDEVRGAFSRLEELAVDAVIVIMEVHLLDAASLKLPPHVQVVVVDSDAGDTYTVVDTDQAGGSRAAVRHLLDLGHDTVWHLGGPEGSFAAQRRTDAWRRTLTEAGRTPPPLVRGDWSAESGYRAGLELAAREDCTAVFAANDQMALGLLRALHERGRRVPEDISVIGFDDIAEAGSFLPPLTTVHQDFAEVGRLCVRAVLRKMRAAGPEQGTTLVPTRLVTRASTAPPPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1B1</accession>
    <name>ARLY_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name type="ordered locus">SCO1570</name>
        <name type="ORF">SCL24.06c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625847.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027854.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L1B1"/>
    <dbReference type="SMR" id="Q9L1B1"/>
    <dbReference type="STRING" id="100226.SCO1570"/>
    <dbReference type="GeneID" id="1097001"/>
    <dbReference type="KEGG" id="sco:SCO1570"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1582"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_2_11"/>
    <dbReference type="InParanoid" id="Q9L1B1"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="PhylomeDB" id="Q9L1B1"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137833" description="Argininosuccinate lyase">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <sequence length="475" mass="50942" checksum="9E2EB1448589A509" modified="2000-10-01" version="1">MSSNSGDVRLWGGRFADGPAEALAKLSASVHFDWRLAPYDIAGSRAHARVLHAAGLLTEDELTRMIAGLDRLEADVADGSFTGTIADEDVHTALERGLLERLGPDLGGKLRAGRSRNDQVATLFRMYLRDHARTVGSLIADLQDALVGLAEAHPDVAMPGRTHLQHAQPVLFAHHVLAHAQALGRDAERLRQWDARTAVSPYGSGALAGSSLGLDPEAVARDLGFEHGSVGNSIDGTASRDFVAEFAFITAMIGVNVSRIAEEIIIWNTKEFSFVTLHDAFSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLMATLKALPLAYNRDLQEDKEPVFDSIDQLEVLLPAFTGMMATLTVHRERMEELAPAGFSLATDIAEWLVKQGVPFRVAHEVAGECVKVAEADGKELDELTDEQFAKISEHLTPEVRTVLNVPGALASRDGRGGTAPSAVAVQLAEVKADVAAQHAWADAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1J6</accession>
    <name>Q9L1J6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long-chain fatty acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2720</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626953.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028538.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2720"/>
    <dbReference type="GeneID" id="1098154"/>
    <dbReference type="KEGG" id="sco:SCO2720"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2775"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="InParanoid" id="Q9L1J6"/>
    <dbReference type="OMA" id="EWIVRDS"/>
    <dbReference type="PhylomeDB" id="Q9L1J6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="642" mass="68758" checksum="0C5E2BC894FCD86B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L206</accession>
    <name>Q9L206_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sugar-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2627</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976172.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2627"/>
    <dbReference type="GeneID" id="1098061"/>
    <dbReference type="KEGG" id="sco:SCO2627"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2673"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_0_11"/>
    <dbReference type="InParanoid" id="Q9L206"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="PhylomeDB" id="Q9L206"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019316">
        <property type="term" value="P:D-allose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB71802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17185" checksum="4115A5E4A811AC25" modified="2000-10-01" version="1">MYLGSDHAGFELKNHLVEWLAAAGHEPVDCGPHIYDAQDDYPPFCLRAAERTAADQGALGIVIGGSGNGEQIAANKVKGVRAALAWSEETASLGRQHNNANVVAVGARMHTQEEATKFVETFLGTPFSGDERHIRRIDMLTSYETTGDLPPVPSHHPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L224</accession>
    <name>Q9L224_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ArsR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6808</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630880.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031196.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6808"/>
    <dbReference type="GeneID" id="1102247"/>
    <dbReference type="KEGG" id="sco:SCO6808"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6918"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_11"/>
    <dbReference type="InParanoid" id="Q9L224"/>
    <dbReference type="OMA" id="KSLCVCD"/>
    <dbReference type="PhylomeDB" id="Q9L224"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="120" mass="13272" checksum="8B68EF1F9D0633B4" modified="2000-10-01" version="1">MSDDGFLEGGSCGPGLNCQPLERSEAEQLSTILRSIADPTRLQLFRLLEQAPDGEACVCDLADSLGLRQSTVSHHLKIMTEAGLLDRERRGTWAWFSVNHEGLRRIRSILDPAPQATKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD09</accession>
    <name>Q9RD09_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0902</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0902"/>
    <dbReference type="GeneID" id="1096325"/>
    <dbReference type="KEGG" id="sco:SCO0902"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.896"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142293_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RD09"/>
    <dbReference type="OMA" id="ESHHYAF"/>
    <dbReference type="PhylomeDB" id="Q9RD09"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="15347" checksum="2A3221A933497DC9" modified="2000-05-01" version="1">MSVEFNHTIVLSQDREKSAHFLAEVLGLEVAEPAGMFLPVTTANGVTLDFATVDIDIPVQHYAFLVSEDDFDGILARLVEGRIPIQADPPGRHPRRINRNDGGRGVYFTDPSGHGMEAFTRPYGSDPASPLNGVTEDVPGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD88</accession>
    <name>Q9RD88_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2863</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627092.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028629.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2863"/>
    <dbReference type="REBASE" id="22993">
        <property type="entry name" value="ScoA3I"/>
    </dbReference>
    <dbReference type="GeneID" id="1098297"/>
    <dbReference type="KEGG" id="sco:SCO2863"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2922"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005588_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RD88"/>
    <dbReference type="OMA" id="DEFHHAE"/>
    <dbReference type="PhylomeDB" id="Q9RD88"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="233"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="446"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="945" mass="105781" checksum="53C0B95B67BA2A8C" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDF4</accession>
    <name>Q9RDF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2537</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2537"/>
    <dbReference type="GeneID" id="1097971"/>
    <dbReference type="KEGG" id="sco:SCO2537"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2582"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057862_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RDF4"/>
    <dbReference type="OMA" id="WYQWLEQ"/>
    <dbReference type="PhylomeDB" id="Q9RDF4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="32906" checksum="775B231538DFFF21" modified="2000-05-01" version="1">MITRAGTAGRDRRRSELREFLMSRRARVSPAEVGLPDGGARRRTPGLRREEVAVLAGVGASWYQWLEQGRDISVSPQVLDAVGRVLRLSNTERRHLYVLAGLNPPAAEVEPSKRDMCEGLRRLIDTWMPYPAHIMDRYYNCVLYNDAAATVLGMRPETTWNCILDFFTDPLYRSRARNWEHNARTVVAQFRATCAANPDDEGFQQVLADLTGASAEFAALWEERDIEDAGQIRKELDHPLVGLLSLESTALQVPARPDLTIVLHTPLEEANTAAKLEWLASPEGRRGAMYPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI34</accession>
    <name>Q9RI34_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0214</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37043">
        <property type="entry name" value="T37043"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624547.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978653.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0214"/>
    <dbReference type="GeneID" id="1095638"/>
    <dbReference type="KEGG" id="sco:SCO0214"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.185"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127487_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RI34"/>
    <dbReference type="OMA" id="LEPWQPG"/>
    <dbReference type="PhylomeDB" id="Q9RI34"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14532" checksum="0D1E5EC4D84C78A8" modified="2000-05-01" version="1">MSSEDGFRALERAECLRLLGSAPVGRIVYTREALPAVLPVNFSLDTDASVVLRTSAGSDLVRAVDGAVVAFEADAFDAHDRSGWSVVVTGRATVVTDPAARARLAENGPRSWVVSRDGLYVRIESEMVTGREIAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI80</accession>
    <name>Q9RI80_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative noncomposite transposon transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36996">
        <property type="entry name" value="T36996"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624441.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0096"/>
    <dbReference type="GeneID" id="1095522"/>
    <dbReference type="KEGG" id="sco:SCO0096"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.82"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_15_3_11"/>
    <dbReference type="InParanoid" id="Q9RI80"/>
    <dbReference type="OMA" id="CVCARLM"/>
    <dbReference type="PhylomeDB" id="Q9RI80"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="138"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="32255" checksum="3CB7E18237EA468B" modified="2000-05-01" version="1">MLRSEVVDVQQLAEYRYRTVREVLGGSPIGEVAARYGTSRQTLHTWRRRFVLEGMPGLLDRSRRPRNSPAGLSAEMEAEICELRRRHLRWGARRIAHELSVRGLESAPSRATVHRVLSRNGLVRAQEQQHPRKYRRWQREAPMHLWQMDLVGGVPLADGRECKMVTGIDDHSRFVVIASVVAVPSARAVCSAFAAAMRRYGVPFEVLTDNGKQFTGRHQRPQPVEVLFERICRENGITQRLTKPRSPTTTGKIERSHRTLREEFLDHVVPFESLAAAQQAIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ33</accession>
    <name>Q9RJ33_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626103.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976987.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1835"/>
    <dbReference type="GeneID" id="1097269"/>
    <dbReference type="KEGG" id="sco:SCO1835"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1857"/>
    <dbReference type="eggNOG" id="ENOG502ZI1B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196127_0_0_11"/>
    <dbReference type="OMA" id="MNMAVVG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="61" mass="6499" checksum="27AF826ADEF957F6" modified="2000-05-01" version="1">MSMAVVGMIAGMALGFAGYFGGFGAFLLVAALGAVGFVVGRFLEGDMELGDFFRTRDDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJI2</accession>
    <name>Q9RJI2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0557</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB57409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624870.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027203.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0557"/>
    <dbReference type="GeneID" id="1095980"/>
    <dbReference type="KEGG" id="sco:SCO0557"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.539"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052806_1_0_11"/>
    <dbReference type="OMA" id="PRIDRYW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB57409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="36007" checksum="2E022F0765C80156" modified="2000-05-01" version="1">MFTSNDGLCGIGELAEGAGVTVKTVRFYSDRGLLPEASRSAGGHRRYGPEALDRLRLIRSLRALGLGVPEVRRILDERHAHGTAGGEGGALEAAVAGRLREVGSELRALRWREAALRLVQEAPPGEQADRLRLIGAVSVPPSTAPLVRFWRGWLPARMPARSAGAFLDVAVPQPPDEPAPAQVLAFARLNALTLAPCRPGTVQPQPEAHRAAGARGAALLYTGLAEAYELAGVHMRRGREPHPGEALDAFVASYTSAYGVRDTPGFRRRLAGQLAADPRLDGYWELVAEVTTAPGARPEPTPGSAHDWLLAALTAGTGAVPDQGTSPRQSKRRVSPGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJQ1</accession>
    <name>Q9RJQ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0589</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624901.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027226.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0589"/>
    <dbReference type="GeneID" id="1096012"/>
    <dbReference type="KEGG" id="sco:SCO0589"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.570"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RJQ1"/>
    <dbReference type="OMA" id="VYGPVEH"/>
    <dbReference type="PhylomeDB" id="Q9RJQ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176909" evidence="2">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="31727" checksum="513DA2335B6A3FE1" modified="2000-05-01" version="1">MDTRLLTTFTVLARTGGFTAAAAELHLAQSTVTVHIRTLERDLGVRLFDRLPTGALLTDAGRRLLERAEEVLDAVARLRAGSAEAGAVSGRVVIGSPESLCASRLPGLVAALRTSHPEVDVHLYAAGTRECVEGLRSGRLDLALLLEEETEFPDVTSEPVGREPLALVAAPGHPLAARERAASWPELAEESFFLLEEGCSYSDALARRLLAVPGTRPRLTRFGSVDAARNCVAAGLGLTLLPLTTVTEELRRGRLVRVEGPGFPAAPVRLARHRRRWTAPAAREVARVLVRHLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJU1</accession>
    <name>Q9RJU1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0369</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624692.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027059.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0369"/>
    <dbReference type="CAZy" id="GH78">
        <property type="family name" value="Glycoside Hydrolase Family 78"/>
    </dbReference>
    <dbReference type="GeneID" id="1095792"/>
    <dbReference type="KEGG" id="sco:SCO0369"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.345"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RJU1"/>
    <dbReference type="OMA" id="FFTAYPR"/>
    <dbReference type="PhylomeDB" id="Q9RJU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176914" description="Alpha-L-rhamnosidase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="360"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="548"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="651"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB55731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1085" mass="117277" checksum="537FD7B13A8D5AC3" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJX1</accession>
    <name>Q9RJX1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1199</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625489.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977632.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1199"/>
    <dbReference type="GeneID" id="1096622"/>
    <dbReference type="KEGG" id="sco:SCO1199"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1198"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RJX1"/>
    <dbReference type="OMA" id="WGLYNTK"/>
    <dbReference type="PhylomeDB" id="Q9RJX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="326" mass="33926" checksum="C3E37404E83B36D7" modified="2000-05-01" version="1">MQAWQVHENGEPGEVMRLADVAPPTPGEGQVLLRVRAANINFPDALMCRGQYQVRPPLPFTPGVEICGETEEGRRVIANPALPHGGFAEYALADARALLPAPDSLDDAEAAALHIGYQTGWFGLHRRARLEAGETLLVHAAAGGVGSAAVQLGKAAGATVIGVVGGSQKAAVARELGCDVVVDRHAEDVVAAVKEATGGRGADVIYDPVGGQAYAQSAKVVAFEGRIVVVGFASGTIPSPALNHALVKNYAILGLHWGLYNTKDPKLVRHCHEQLTELAARGAIKPLVSERVPLADAADAVQRVADGRTTGRLAVVPENLDKGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK52</accession>
    <name>Q9RK52_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624651.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027020.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0325"/>
    <dbReference type="GeneID" id="1095749"/>
    <dbReference type="KEGG" id="sco:SCO0325"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.299"/>
    <dbReference type="HOGENOM" id="CLU_2036651_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="121" mass="12990" checksum="A8C7D63069419070" modified="2000-05-01" version="1">MRVTGTSAHERDGVDVIVRMSGSAYDSWAGFEEITVRSCFTVRVSPASRWREDPDDVDCPEDPALTFAPPVRGNHFDPQDCLLARVVPGATEVRGAAPHPPDARSGRPQVACALDPAAAPH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK61</accession>
    <name>ACP_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name type="ordered locus">SCO0549</name>
        <name type="ORF">SCF11.29c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978314.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RK61"/>
    <dbReference type="SMR" id="Q9RK61"/>
    <dbReference type="STRING" id="100226.SCO0549"/>
    <dbReference type="GeneID" id="1095972"/>
    <dbReference type="KEGG" id="sco:SCO0549"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.529"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RK61"/>
    <dbReference type="OMA" id="IEDRWQI"/>
    <dbReference type="PhylomeDB" id="Q9RK61"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180198" description="Acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <sequence length="92" mass="9876" checksum="8A1800D2395AA2B3" modified="2000-05-01" version="1">MPSTADERQLLDELRDLLAATVEDLTVEEIGPDSSLQDDLGVDSLARLELVAAIEDRWQIEVPQEQADRLTTVRQIAAHLAEAVAAPAGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK65</accession>
    <name>Q9RK65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0545</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027193.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0545"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="CAZy" id="GH55">
        <property type="family name" value="Glycoside Hydrolase Family 55"/>
    </dbReference>
    <dbReference type="GeneID" id="1095968"/>
    <dbReference type="KEGG" id="sco:SCO0545"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.525"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013797_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RK65"/>
    <dbReference type="OMA" id="EYKVFAP"/>
    <dbReference type="PhylomeDB" id="Q9RK65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331850" evidence="2">
        <location>
            <begin position="28"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="848" mass="89531" checksum="13CEB7C7F241B231" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK69</accession>
    <name>Q9RK69_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0541</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624855.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978322.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0541"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="1095964"/>
    <dbReference type="GeneID" id="1095964"/>
    <dbReference type="KEGG" id="sco:SCO0541"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.521"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RK69"/>
    <dbReference type="OMA" id="YVPWYLH"/>
    <dbReference type="PhylomeDB" id="Q9RK69"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="201"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB59598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="48368" checksum="B7D0CEBAB4E4137F" modified="2000-05-01" version="1">MSTAHPSAPKITFVGAGSVVFTQGLLADLFAFDELKSAHIALHDIDAERLATARAAAEYIAAERGARPRVTAHADRREALAGADFVINIVQVGMGEATRTDFEVPARYGLRQTIGDTLGVGGIFRALRTFPLLKALGEDIAEVCPDAWLLNYTNPMAMNVQYLAEATGLTRVVGLCHSVYWTVQGLCELLKVPYEEVTYQAAGVNHQAWVLRLEHGGEDLHPRLDALIAEDPQLRRRVRMDMYRRLGHYPTETSEHSSEYVPWYLHHDSEVERLRLPVGAYLGIVDENVAEYERTRDALACGAPLTVEGTMEYAPQIIHSMVTGTPRTVYGNVPNHGLIENLPARGTVEVPCLVDSAGLQPTRVGALPPQLAALNRAYLSTTDLVVRAATEDDPRHIRHAAMADPATAATLRVEEIWQLCDDMVRAHGDRLQPGLRGVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKF8</accession>
    <name>Q9RKF8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Beta-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO3479</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 7"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627682.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029018.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000041.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKF8"/>
    <dbReference type="STRING" id="100226.SCO3479"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1098916"/>
    <dbReference type="KEGG" id="sco:SCO3479"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3538"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RKF8"/>
    <dbReference type="OMA" id="DSFFYLW"/>
    <dbReference type="PhylomeDB" id="Q9RKF8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="710"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="968"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB61803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="995" mass="108856" checksum="DF5DEB6958A3F8F8" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKT2</accession>
    <name>Q9RKT2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6260</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAB60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630360.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030775.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6260"/>
    <dbReference type="GeneID" id="1101701"/>
    <dbReference type="KEGG" id="sco:SCO6260"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6374"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKT2"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="PhylomeDB" id="Q9RKT2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="382" mass="41456" checksum="D9B23FC69DE88177" modified="2000-05-01" version="1">MSTYRDFTAPIGSRRAPVLRTVGTRERRSHLTAPRVPTVGIDIGGTKVMAGVVDADGNILEKLRTETPDKSKSPKVVEDTIVELVLDLSDRHDVHAVGIGAAGWVDADRNRVLFAPHLSWRNEPLRDRIAGRLAVPVLVDNDANTAAWAEWRFGAGRGEDHLVMITLGTGIGGAILEDGQVKRGKYGVAGEFGHMQVVPGGHRCPCGNRGCWEQYSSGNALVREARELAAADSPVAYGIIEHVKGSIGDITGPMITELAREGDAMCVELLQDIGQWLGVGIANLAAALDPSCFVIGGGVSAADDLLIGPARDAFKRQLTGRGYRPEARIVRAQLGPEAGMVGAADLSRLVARRFRRAKRRRVERYERYERYAEARRESRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S228</accession>
    <name>Q9S228_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative partitioning or sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36875">
        <property type="entry name" value="T36875"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626043.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977053.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1772"/>
    <dbReference type="GeneID" id="1097203"/>
    <dbReference type="KEGG" id="sco:SCO1772"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1789"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S228"/>
    <dbReference type="OMA" id="CEFFALR"/>
    <dbReference type="PhylomeDB" id="Q9S228"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="86"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="37028" checksum="EA0ACE96E6635EB4" modified="2000-05-01" version="1">MSMDGQHVNAMAGDGSGAPRNHFADYDELPEGHFYDPDAEYEPDPEYAATLAPDAARQRRERIGPTGRPLPYFPIPGPLTDHGPAKIIAMCNQKGGVGKTTSTINLGAALAEYGRRVLLVDFDPQGALSVGLGVNPMELDLTVYNLLMERGMAADEVLLKTAVPNMDLLPSNIDLSAAEVQLVSEVARESTLQRALKPLMDDYDYIVIDCQPSLGLLTVNALTAAHKVIVPLECEFFALRGVALLTETIEKVQERLNPDLELDGILATMYDSRTVHSREVLARVVEAFDDHVYHTVIGRTVRFPETTVAGEPITTYASNSVGAAAYRQLAREVLARCHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S231</accession>
    <name>Q9S231_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1769</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36872">
        <property type="entry name" value="T36872"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626040.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027964.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1769"/>
    <dbReference type="GeneID" id="1097200"/>
    <dbReference type="KEGG" id="sco:SCO1769"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1786"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_1_11"/>
    <dbReference type="InParanoid" id="Q9S231"/>
    <dbReference type="OMA" id="DGWRFYT"/>
    <dbReference type="PhylomeDB" id="Q9S231"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB52833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="24288" checksum="EF827A676A00D2CF" modified="2000-05-01" version="1">MSERITEAEEATEAEGGPDGVAALDLKPALEAVLMVVDEPATEERLAKILQRPRRRIADALRELADEYAVQGRGFELRLIAGGWRFYSRPEYAAAVEGFVLDGQHARLTQAALETLAVVAYRQPVSRGRVSAVRGVNCDGVMRTLLQRGLVEEAGTEPETGAILYVTTNYFLERMGLRGLDELPELAPFLPEAEAIEADTLEGVPSFDPDAPDAGDADDKTEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WVX8</accession>
    <name>RSBV_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Anti-sigma-B factor antagonist</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Anti-anti-sigma-B factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rsbV</name>
        <name type="synonym">bldG</name>
        <name type="ordered locus">SCO3549</name>
        <name type="ORF">SCH5.12c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-03" db="EMBL/GenBank/DDBJ databases">
            <title>The bldG gene of Streptomyces coelicolor A3(2) encodes a putative anti-anti-sigma factor.</title>
            <authorList>
                <person name="Leskiw B.K."/>
                <person name="Warawa J."/>
                <person name="Bignell D.R."/>
                <person name="Strap J.L."/>
                <person name="Chater K.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / J1501</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="FEMS Microbiol. Lett." volume="225" first="93" last="99">
            <title>The putative anti-anti-sigma factor BldG is post-translationally modified by phosphorylation in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Bignell D.R."/>
                <person name="Lau L.H."/>
                <person name="Colvin K.R."/>
                <person name="Leskiw B.K."/>
            </authorList>
            <dbReference type="PubMed" id="12900026"/>
            <dbReference type="DOI" id="10.1016/S0378-1097(03)00504-4"/>
        </citation>
        <scope>PHOSPHORYLATION AT SER-57</scope>
        <scope>MUTAGENESIS OF SER-57</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-6406852">
            <id>Q9WVX8</id>
        </interactant>
        <interactant intactId="EBI-6412450">
            <id>Q9R3X8</id>
            <label>prsH</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>3</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-6406852">
            <id>Q9WVX8</id>
        </interactant>
        <interactant intactId="EBI-6406852">
            <id>Q9WVX8</id>
            <label>rsbV</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-6406852">
            <id>Q9WVX8</id>
        </interactant>
        <interactant intactId="EBI-6406843">
            <id>Q9X914</id>
            <label>SCO3548</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by RsbW on a serine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AF134889">
        <property type="protein sequence ID" value="AAD30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36670">
        <property type="entry name" value="T36670"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627747.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975386.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9WVX8"/>
    <dbReference type="SMR" id="Q9WVX8"/>
    <dbReference type="IntAct" id="Q9WVX8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3549"/>
    <dbReference type="iPTMnet" id="Q9WVX8"/>
    <dbReference type="GeneID" id="1098985"/>
    <dbReference type="KEGG" id="sco:SCO3549"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3605"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_11"/>
    <dbReference type="InParanoid" id="Q9WVX8"/>
    <dbReference type="OMA" id="MNLAINI"/>
    <dbReference type="PhylomeDB" id="Q9WVX8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="IntAct"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000194198" description="Anti-sigma-B factor antagonist">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolished phosphorylation." evidence="3">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12900026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="113" mass="12321" checksum="DE2708636F8C9B24" modified="1999-11-01" version="1">MDLSLSTRTVGDRTVVEVGGEIDVYTAPKLREQLVELVNDGSFHLVVDMEGVDFLDSTGLGVLVGGLKRVRAHEGSLRLVCNQERILKIFRITGLTKVFPIHTSVEEAVAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX06</accession>
    <name>Q9WX06_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36276">
        <property type="entry name" value="T36276"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627538.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004984898.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3328"/>
    <dbReference type="GeneID" id="1098762"/>
    <dbReference type="GeneID" id="24309677"/>
    <dbReference type="KEGG" id="sco:SCO3328"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3388"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_4_0_11"/>
    <dbReference type="InParanoid" id="Q9WX06"/>
    <dbReference type="OMA" id="RYRWVMA"/>
    <dbReference type="PhylomeDB" id="Q9WX06"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="70" mass="7798" checksum="60D2F8A86796DAC0" modified="1999-11-01" version="1">MAAAGERPLNEVQFLTVAEVASVMRVSKMTVYRLVHSGHLPAIRVGRSFRVPEQAVHEYLRESYVGVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX27</accession>
    <name>Q9WX27_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3306</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36254">
        <property type="entry name" value="T36254"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627516.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028898.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3306"/>
    <dbReference type="GeneID" id="1098740"/>
    <dbReference type="KEGG" id="sco:SCO3306"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3367"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_11"/>
    <dbReference type="InParanoid" id="Q9WX27"/>
    <dbReference type="OMA" id="GGCFNNY"/>
    <dbReference type="PhylomeDB" id="Q9WX27"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="68"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="42819" checksum="D4382E16CE2C366F" modified="1999-11-01" version="1">MTVTENVPAATASLPPLAARARSIGGSPVRDILAVTARPEVINFAGGLPAPELFDAEGIAAAYRDVLAETPARALQYSTTEGEPALRAALAARTSARGLATDADDILVTTGSQQALSLLATALLEPGDTVLVERPCYLAALQAFGFAGARVVAVPGDEHGIDPGALEELVVRERPKLLYTVPTFSNPTGRTVPAARRAAVAEVAGRCGLWIVEDDPYGELRFEGERVPWIASYEGARDRTVLLGSFSKVMAPGLRLGWLRAPAELRRACAVAKQAADLHTPTVNQLAAARYLADRDLDAHVARVAAVYGERRDAMLAGLADALPAGSVWTRPEGGMFLWARLPQGYDTTALLPEVVRHDVAYVPGAPFHAGEPDRATLRLCFVTQTPDEIAEGLRRLGEGLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7M8</accession>
    <name>Q9X7M8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6722</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35247">
        <property type="entry name" value="T35247"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630795.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972274.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6722"/>
    <dbReference type="DNASU" id="1102161"/>
    <dbReference type="GeneID" id="1102161"/>
    <dbReference type="KEGG" id="sco:SCO6722"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6829"/>
    <dbReference type="eggNOG" id="ENOG5032RFA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126599_0_1_11"/>
    <dbReference type="OMA" id="VEVCWTF"/>
    <dbReference type="PhylomeDB" id="Q9X7M8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB40672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="138" mass="15261" checksum="F531BA295144ABA5" modified="1999-11-01" version="1">MSTVIEQSVEARLVAAAPRMPSIPATLHYDRADPFAVRMTFPAPATLEGVEVCWTFSRELLIAGMQEPNGHGDVRVRPYAYDRTVLEFHAPEGTAVIHVRSGELRRFLQAAGELVPVGLEHLQLDLDHDLAELMRGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X882</accession>
    <name>Q9X882_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3290</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36110">
        <property type="entry name" value="T36110"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627501.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975544.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3290"/>
    <dbReference type="GeneID" id="1098724"/>
    <dbReference type="KEGG" id="sco:SCO3290"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3351"/>
    <dbReference type="eggNOG" id="COG4271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115277_0_0_11"/>
    <dbReference type="OMA" id="AMRNDIN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019302">
        <property type="entry name" value="TIR-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10137">
        <property type="entry name" value="TIR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="27152" checksum="034E1D552ED26A1D" modified="1999-11-01" version="1">MSGQQFHGNSFGQGSTNNFGGNQSAGNTDTTQTFGDNSPVHAAPPAPSAPPAQPYADGWRRPAAPVPGDAERARSVFVVHGRDDQVRREMYELLRRLDLRPKEWEDLVRATGQASPFLGDVVAGAPAQAQAALVLLTPDDVVTLHPELRGHNEPDHETRPVCQPRPNVLIELGMVLMAYPERTLIVEVGGVRPIADIAGRNVIRFDGSDTALGKVVERLKLAGCTVNDTGSDWRQTYPFRHLSAYHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8E9</accession>
    <name>Q9X8E9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3276</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36236">
        <property type="entry name" value="T36236"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627488.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028880.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3276"/>
    <dbReference type="GeneID" id="1098710"/>
    <dbReference type="KEGG" id="sco:SCO3276"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3337"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_7_0_11"/>
    <dbReference type="InParanoid" id="Q9X8E9"/>
    <dbReference type="OMA" id="GCALVGQ"/>
    <dbReference type="PhylomeDB" id="Q9X8E9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="414"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB40334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="499" mass="52142" checksum="2B51984DE9063E97" modified="1999-11-01" version="1">MTPTTPAARLRALKPDWLNDPKVWRTEILAGLVVALALIPEAISFSIIAGVDPAIGLFASFTMAVTISIVGGRRAMISAATGAVALVIAPMNREHGLGYLIATVILAGVFQIVLGAVGVAKLMRFVPRSVMTGFVNALAVMIFMAQVPEMHDVPWPVYPLIVGGLALMVFFPKVTRVVPAPLVSIVILTVITVAAGIAVPTVGDKGELPSSLPVPGLPDVPFTLDTLTTVAPYALAMALVGLMESLMTARLVDDITDTHSSKTRESIGQGVANIVTGFFGGMGGCAMIGQTMINVKVSGARTRVSTFLAGSFLMVLCIVFGPVVSDIPMAALVAVMVMVAFGTFDWHSVAPKTLKRMPAGEIAVMIITVIVVVATDNLAIGVVVGTVTAMVVFARRVAHLAQVTAVTDPDGTTVVYRVTGELFFASSNDLVGQFDYAGDPDRVVIDLSAAHIWDASSVAALDAIETKYGQRGKSVEITGLNTPSADLHGRLTGELTGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W7</accession>
    <name>Q9X8W7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3685</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36620">
        <property type="entry name" value="T36620"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627877.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975253.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3685"/>
    <dbReference type="GeneID" id="1099121"/>
    <dbReference type="KEGG" id="sco:SCO3685"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3743"/>
    <dbReference type="eggNOG" id="ENOG50328WC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100184_3_0_11"/>
    <dbReference type="PhylomeDB" id="Q9X8W7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="133" mass="14756" checksum="AAA1C97FB57B870A" modified="1999-11-01" version="1">MTLNTIPLRPHTAPFRPRAARLVLGSASRFGRPDGAWWPRTRDLARELGELADVIDPLWGRLTHVAVNPRHWQPVPRRGVVVNGHEVAVDRFAEVLNPHRILLQSYTAGRWDLLVVPPPTSASSAARLMAAVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-10" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC0</accession>
    <name>TAL2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transaldolase 2</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tal2</name>
        <name type="ordered locus">SCO1936</name>
        <name type="ORF">SCC22.18</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36008">
        <property type="entry name" value="T36008"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976882.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAC0"/>
    <dbReference type="SMR" id="Q9XAC0"/>
    <dbReference type="STRING" id="100226.SCO1936"/>
    <dbReference type="GeneID" id="1097370"/>
    <dbReference type="KEGG" id="sco:SCO1936"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1963"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050771_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAC0"/>
    <dbReference type="OMA" id="EGVYSAI"/>
    <dbReference type="PhylomeDB" id="Q9XAC0"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173642" description="Transaldolase 2">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <sequence length="372" mass="40588" checksum="E6487BA466481C08" modified="1999-11-01" version="1">MTDALKRLSDEGVAIWLDDLSRKRITSGNLAELIDQQHVVGVTTNPSIFQKAISQGDGYDQQLADLAVRGVTVEEAIRMITTADVRDAADILRPVYDNTGGKDGRVSIEVDPRLAHNTHATVAEAKQLAWLVDRPNTFIKIPATEAGLPAIAETIGLGISVNVTLIFSLERYRKVMDAFLTGLEKAKERGLDLSQIHSVASFFVSRVDTEIDKRIDALGTDEAKAQRGKAAVANARLAYQAYEEVFGTDRWAALEKAGANKQRPLWASTGVKDKAYSDTMYVTDLVAPNTVNTMPEATLLATEDHGEITGDAVAGSYERARADLDAIEKLGISYDEVVQLLEKEGVDKFEDAWNDLLKSTEAELKRLAPSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAK3</accession>
    <name>Q9XAK3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35367">
        <property type="entry name" value="T35367"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627794.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029113.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3599"/>
    <dbReference type="ESTHER" id="strco-SC66T3.10C">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1099035"/>
    <dbReference type="KEGG" id="sco:SCO3599"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3656"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_1_2_11"/>
    <dbReference type="InParanoid" id="Q9XAK3"/>
    <dbReference type="OMA" id="HVMARLG"/>
    <dbReference type="PhylomeDB" id="Q9XAK3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="58"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="33931" checksum="FF041D2B56E665FC" modified="1999-11-01" version="1">MPETDLTVTADDGTSLAGTLSLPAGPGPHPAVLLLHGSGPLDREGNTPRLPLNLGRPLADALAAAGVAALRYDRRGAGSTPGVWEESGFTDNRRDASAALRALAAHPDIRPDAVGVVGHSEGALHAMTLAARQEVAAVVLLAGFARGGEAAFRWQAASVFGGMPAPVRLLRRPLGALGERVLARVKRTRTDVARIAGLRVNARWVREMLVHDTRDDLAAVPAAVPVLAVTGDKDVQVPPADLDEIRRLVPGGHTEIHRVPDLTHVLRRDTGRPTLRSYRRLLREPVDPELLALVATWLQARLREPSGAPAEERRTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAL4</accession>
    <name>Q9XAL4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6716</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB45590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35034">
        <property type="entry name" value="T35034"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630789.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031129.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6716"/>
    <dbReference type="GeneID" id="1102155"/>
    <dbReference type="KEGG" id="sco:SCO6716"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6823"/>
    <dbReference type="HOGENOM" id="CLU_2865934_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6521" checksum="C9A635172295B433" modified="1999-11-01" version="1">MCRAAGGVAAALLTEAAAEPLAVTGALGECEDRPAPWRELPRAPRRHPAPGVRGAAPGEITAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4X8</accession>
    <name>Q9Z4X8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glycolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3228</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36246">
        <property type="entry name" value="T36246"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627441.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9Z4X8"/>
    <dbReference type="STRING" id="100226.SCO3228"/>
    <dbReference type="GeneID" id="1098662"/>
    <dbReference type="KEGG" id="sco:SCO3228"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3291"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z4X8"/>
    <dbReference type="OMA" id="DPSLDWE"/>
    <dbReference type="PhylomeDB" id="Q9Z4X8"/>
    <dbReference type="BRENDA" id="1.1.3.46">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="281"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="304"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB38520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="377" mass="38744" checksum="2E9F5F3CC2402CCA" modified="1999-05-01" version="1">MREPLTLDDFARLARGQLPAATWDFIAGGAGRERTLAANEAVFGAVRLRPRALPGIEEPDTSVEVLGSRWPAPVGIAPVAYHGLAHPDGEPATAAAAGALGLPLVVSTFAGRSLEEVARAASAPLWLQLYCFRDHETTLGLARRARDSGYQALVLTVDTPFTGRRLRDLRNGFAVPAHITPANLTGTAAAGSATPGAHSRLAFDRRLDWSFVARLGAASGLPVLAKGVLTAPDAEAAVAAGVAGIVVSNHGGRQLDGAPATLEALPEVVSAVRGRCPVLLDGGVRTGADVLAALALGARAVLVGRPALYALAVGGASGVRRMLTLLTEDFADTMVLTGHAATGTIGPDTLAPPHHAPPHHGPPTAPRPAPHRDRSHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBR1</accession>
    <name>COAD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="synonym">kdtB</name>
        <name type="ordered locus">SCO5568</name>
        <name type="ORF">SC7A1.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35652">
        <property type="entry name" value="T35652"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629703.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973426.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBR1"/>
    <dbReference type="SMR" id="Q9ZBR1"/>
    <dbReference type="STRING" id="100226.SCO5568"/>
    <dbReference type="GeneID" id="1101009"/>
    <dbReference type="KEGG" id="sco:SCO5568"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5657"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBR1"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="PhylomeDB" id="Q9ZBR1"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156282" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="159" mass="17813" checksum="F5003C16A92361FD" modified="1999-05-01" version="1">MRRAVCPGSFDPITNGHLDIIARASSLYDEVYVAVMINQAKKGLFEIEERIDLIRRVTAEYGNVRVESFHGLLVDFCKQREIPAIVKGLRAVSDFDYELQMAQMNNGLSGVETLFIPTNPTYSFLSSSLVKEVATWGGDVAHLVPPLVLEALTERLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBR4</accession>
    <name>Q9ZBR4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DhaL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5565</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35649">
        <property type="entry name" value="T35649"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629700.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030309.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5565"/>
    <dbReference type="GeneID" id="1101006"/>
    <dbReference type="KEGG" id="sco:SCO5565"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5654"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_0_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBR4"/>
    <dbReference type="OMA" id="TRTIPQG"/>
    <dbReference type="PhylomeDB" id="Q9ZBR4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="589" mass="59495" checksum="AF36F7C6AE296AA5" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBX7</accession>
    <name>Q9ZBX7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3955</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36061">
        <property type="entry name" value="T36061"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628139.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029340.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3955"/>
    <dbReference type="GeneID" id="1099391"/>
    <dbReference type="KEGG" id="sco:SCO3955"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4027"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083305_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBX7"/>
    <dbReference type="OMA" id="GYANRHR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="74"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="37837" checksum="FB44262B208D8DC8" modified="1999-05-01" version="1">MPYLRATAPASEAAPAALLTLGLTTGRFGGVALRASSTAGADRAGTAGRGWHGMDGTPTAATTTTAGLRAELRGFREVQRLAYECAEAVAARLEPGVTERDAARMQRAWLRERGVRDWFHLPFAWFGDRTAFTGFRVPLQFFPTNRRLEPGMPFILDLTPVHRGFTADIGYSGALGPNPVQHRLAADLAAHRELILREVRERRPLREIYEDVDRLMVRQGCANRHRAYPFGVIAHKVDRVRERRPAPRLFGFGTRALKGLASDALHGHREGWSPLWSPYRFSDHPPHPGLWAVEPHLGFRGTGAKFEEILVVTDSADPEESAFWLDDDLPHVRRWAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O50481</accession>
    <name>O50481_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein SC4H8.02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5763</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35133">
        <property type="entry name" value="T35133"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629888.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973261.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5763"/>
    <dbReference type="TCDB" id="2.A.78.2.2">
        <property type="family name" value="the branched chain amino acid exporter (liv-e) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101205"/>
    <dbReference type="KEGG" id="sco:SCO5763"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5852"/>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065777_0_0_11"/>
    <dbReference type="InParanoid" id="O50481"/>
    <dbReference type="OMA" id="WPYKLGL"/>
    <dbReference type="PhylomeDB" id="O50481"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="25582" checksum="86EF85085259E7D9" modified="1998-06-01" version="1">MTEQTALPDAPDTGGAGAKPDAAVVRDALGVGVAVGLSGFAFGVTSAGSGLTLAQTCALSLLVFTGASQFALVGALAAGGNPLTAAAGAFFLGVRNAFYGLRLSQLLALPRAVRPFAAQWVIDETTAVALAQPTRRGVRIGFTVTGLTLYVLWNLTTLLGALGAEAIGDTDAWGLDAAGPAVFLALLAPMLKNTTERAVAALAVLLGLGLLPVLPAGVPVLVAALAAPLVLWARGRRAGDTEDGAARGTAEGEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O69865</accession>
    <name>O69865_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lysine/ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6035</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34715">
        <property type="entry name" value="T34715"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630146.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030609.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6035"/>
    <dbReference type="GeneID" id="1101476"/>
    <dbReference type="KEGG" id="sco:SCO6035"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6135"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_3_11"/>
    <dbReference type="InParanoid" id="O69865"/>
    <dbReference type="OMA" id="FNGLYEM"/>
    <dbReference type="PhylomeDB" id="O69865"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="PTHR11482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="402" mass="42261" checksum="C4EB768AB553C465" modified="1998-08-01" version="1">MSPLTAADLGAPLAAALAAATEDRLVYDLAGIERRHDTLRNELPGVHVRFAMKACPVDEVLAALAGRGAGADAASPGEVEQALRAGVPAGRVHYGNTVKSDRNIAEAHRLGVRTFATDSLQDVAALAVHAPGARVFCRVATGGAGALWGLSNKFGCPPGDAVRVLVAARDAGLVPAGLSVHVGSQQMTSEAWHGAVDDLGDVLRALGRHGIRVDHVNLGGGLPALGYRDRHGAPLDPPLDKIFAVIREGMDELRRIHGGHLDFVVEPGRHLVADHGAIRAHVVRLTERRAADGERQHWLYLSCGKFNGLYEMDALQYRLVFPGHPDGPCVPAVVAGPTCDSDDAYSHEEGLVPVPAALASGDPVWVLSCGAYATSYTTRGFNGFAPLPYAFAGRPERTGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O69899</accession>
    <name>O69899_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5611</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34796">
        <property type="entry name" value="T34796"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629745.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030337.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101052"/>
    <dbReference type="KEGG" id="sco:SCO5611"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5702"/>
    <dbReference type="eggNOG" id="ENOG5031WF9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_62_11_11"/>
    <dbReference type="InParanoid" id="O69899"/>
    <dbReference type="PhylomeDB" id="O69899"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="71" mass="7863" checksum="C0E35FAB79BD2DBB" modified="1998-08-01" version="1">MPARTFSPDALRQIRRQRGVTQYKLAASLGVHNTAISHYENGHRRPDVETLATIADVLGARMDDFVTARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O69934</accession>
    <name>O69934_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34900">
        <property type="entry name" value="T34900"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630493.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030895.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6406"/>
    <dbReference type="GeneID" id="1101845"/>
    <dbReference type="KEGG" id="sco:SCO6406"/>
    <dbReference type="eggNOG" id="ENOG5033RJG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1926324_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="14251" checksum="0309E4BD911ECF23" modified="1998-08-01" version="1">MTDDVRNIVLGVLAAGISATLGWLARTYLWKRKLRRKQAFLGLPDGSESLLVVNRDPAASEPAVHRFDVFALLELAALVKDCGAHVQVVTQDMVGQGFGERTEFCVGGPGSNRPVPRLPLWTQEPAARMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O69977</accession>
    <name>O69977_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5801</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35121">
        <property type="entry name" value="T35121"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629925.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973221.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5801"/>
    <dbReference type="GeneID" id="1101243"/>
    <dbReference type="KEGG" id="sco:SCO5801"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5893"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039848_2_1_11"/>
    <dbReference type="InParanoid" id="O69977"/>
    <dbReference type="OMA" id="WEIYRAD"/>
    <dbReference type="PhylomeDB" id="O69977"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA18337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="231" mass="24941" checksum="BA8EBEE23EF4E38E" modified="1998-08-01" version="1">MNSTDASADDTLDLHLPEEFVALFRSPAHDAAEAGTARAREDLLDGIADWGPSDTPAGVFHLVPADLERDVPLIARWMNDPAVAAYWELTGPQSVTADHLRAQLAGDGRSVPCVGTLDGVPMSYWEIYRADLDPLARYCPVRPHDTGVHLLIGDGAHRGRGLGTELIRAVVDLVLAGRPACTRVLAEPDVRNRQSVAAFLGAGFRPTGEVDLPTKRAVLMIRAREAREQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O69978</accession>
    <name>O69978_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5802</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35122">
        <property type="entry name" value="T35122"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629926.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030465.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5802"/>
    <dbReference type="GeneID" id="1101244"/>
    <dbReference type="KEGG" id="sco:SCO5802"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5894"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_2_0_11"/>
    <dbReference type="InParanoid" id="O69978"/>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="PhylomeDB" id="O69978"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="664" mass="71464" checksum="B9D84DAF1C4F479A" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O86535</accession>
    <name>LEUD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber>4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha-IPM isomerase</fullName>
            <shortName>IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">leuD</name>
        <name type="ordered locus">SCO5554</name>
        <name type="ORF">SC1C2.35</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29084">
        <property type="entry name" value="T29084"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030306.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86535"/>
    <dbReference type="SMR" id="O86535"/>
    <dbReference type="STRING" id="100226.SCO5554"/>
    <dbReference type="GeneID" id="1100994"/>
    <dbReference type="KEGG" id="sco:SCO5554"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5642"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_0_1_11"/>
    <dbReference type="InParanoid" id="O86535"/>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="PhylomeDB" id="O86535"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000141898" description="3-isopropylmalate dehydratase small subunit">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="197" mass="22213" checksum="FEE30F68A1ECE72E" modified="1998-11-01" version="1">MEAFTKHTGRAVPLRRSNVDTDQIIPAHWLKKVTRDGFEDGLFEAWRKDPEFVLNRPEREGATVLVAGPDFGTGSSREHAVWALQNYGFKTVVSSRFADIFRGNSLKNGLLTVVLDQKTVDALWELVERDPQAEITVDLEAREVRAEGVTASFELDENSRWRLLNGLDDISITLQNEADIAAYEAKRPSFKPQTVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O86599</accession>
    <name>O86599_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6234</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37232">
        <property type="entry name" value="T37232"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630335.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030756.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6234"/>
    <dbReference type="CAZy" id="CBM10">
        <property type="family name" value="Carbohydrate-Binding Module Family 10"/>
    </dbReference>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="GeneID" id="1101675"/>
    <dbReference type="KEGG" id="sco:SCO6234"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6348"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018488_1_1_11"/>
    <dbReference type="InParanoid" id="O86599"/>
    <dbReference type="OMA" id="GTAPNGY"/>
    <dbReference type="PhylomeDB" id="O86599"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.32.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002883">
        <property type="entry name" value="CBM10/Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036601">
        <property type="entry name" value="CBM10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009031">
        <property type="entry name" value="CBM_fam10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02013">
        <property type="entry name" value="CBM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01064">
        <property type="entry name" value="CBM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51763">
        <property type="entry name" value="CBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174875" evidence="4">
        <location>
            <begin position="37"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="CBM10" evidence="5">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA20610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="384" mass="39847" checksum="B8AD158E3FD3BD11" modified="1998-11-01" version="1">MRKPRSTLITTAGMAFAAVLGLLFALAGPSAGRAEAAAGGIHVSNGRVLEGNGSVFVMRGVNHAYTWYPDRTGSIADIAAKGANTVRVVLSSGGRWTKTSASEVSALIGQCKANKVICVLEVHDTTGYGEDGAATSLDQAADYWVSVKSALEGQEDYVVVNIGNEPFGNTNYTAWTDATKSAIGKLRGAGLDHALMVDAPNWGQDWSGTMRSNAASVFASDPDRNTVFSVHMYGVYDTAAEVRDYLNAFVGSGLPIVVGEFGDQHSDGNPDEDAIMATAQSLGVGYLGWSWSGNGGGVEYLDMVNGFDPNSLTSWGNRIFYGSNGIAATSRTATVYGGGGGSTGGTAPNGYPYCVNGGASDPDGDGWGWENSRSCVVRGSAADH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O86662</accession>
    <name>O86662_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6370</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34981">
        <property type="entry name" value="T34981"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630461.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030867.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6370"/>
    <dbReference type="TCDB" id="2.A.28.2.8">
        <property type="family name" value="the bile acid:na(+) symporter (bass) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101811"/>
    <dbReference type="KEGG" id="sco:SCO6370"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6482"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063851_0_0_11"/>
    <dbReference type="OMA" id="TIMPVAN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="344" mass="35350" checksum="19DAC4BAB17035A4" modified="1998-11-01" version="1">MHTRAASWLRHRLGRAVVLFYALALVLPAPGLWLRRPHPLPPSHLTLHTAPLLLSLVLFSAGLQVPVRALGALLRRPKALLAGLVLHLAIPLAVVPFVAFLLRRTPDADGGSGLLTAMILVVAMPVAAGATVWTDKGEGDQPTMVGLVLASTLLSPLTTPVLLATLSPLLSGGYAHTLAATGRLSEGGFTLTAVVLPCAAGLLCALVLPAHWLGRLVTAVAPSAMAGSLVLTYVNASGALGSVLARPRPLLFAAALAVAALVCLLSFVLGRVAARLLRLDAATASSLTLACGMNNSSASAVLITASLPDKPHLLLPVLAYGLLQKTAANRIVTRLRPPPIAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O86741</accession>
    <name>O86741_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polyamine-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5658</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35440">
        <property type="entry name" value="T35440"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629788.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030369.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5658"/>
    <dbReference type="GeneID" id="1101097"/>
    <dbReference type="KEGG" id="sco:SCO5658"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5742"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_2_11"/>
    <dbReference type="InParanoid" id="O86741"/>
    <dbReference type="OMA" id="FWMDNYA"/>
    <dbReference type="PhylomeDB" id="O86741"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="399" mass="44491" checksum="6A6DE3F5FC79C3D6" modified="1998-11-01" version="1">MPLLPKTPSPSRRTLLRGLGGSAALGALGTLAGCGVPAAYVAPGDRAATDRSATERRLIWANWPLYIDTDDRHPSRRPTLEAFEKETGLSVDYIEEINDNDEFFGKISPSLMNHQPTDRDLIVISDWMCGRFVRLGWVQEMDRSRQPNVTKYLDPLLRSPAFDPGRKFTVPWQSGITGIAYNRHRLGREIRHVSDLWAADLKGRVTLLSGMDEAFALLMQGNGVDITDWKTDDFHRICDQVEKQVAKGQIRRFTGNDYIKDLSSGDVLACQAYSGDVIQLQADDPDIEFVVPEEGAELWAESLMIPDLARHKANAERLIDHYYRPEVAAELAAWVNYVCPVPAARDVLASSDDEETAALAEDPLIFPDAAMRERLAIARDISAGERTEFAKRWNGIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O86804</accession>
    <name>O86804_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4765</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35594">
        <property type="entry name" value="T35594"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4765"/>
    <dbReference type="GeneID" id="1100206"/>
    <dbReference type="KEGG" id="sco:SCO4765"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4837"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082566_0_1_11"/>
    <dbReference type="InParanoid" id="O86804"/>
    <dbReference type="OMA" id="CWKLNDR"/>
    <dbReference type="PhylomeDB" id="O86804"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174893" description="MOSC domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="40"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25209" checksum="5714510708288C89" modified="1998-11-01" version="1">MAYRSGMHPSAMRLLSVNLGRAKAVPYTDQPEGVTGIDKRPADGPVRVAVPGSEGFGASGLAGDTVCDTRHHGGDEQAVYAMAREDLDDWERTLGRELPNGAFGENLTTTGLDLTGALIGERWRVGAELLLELTSGRIPCRTFQGHMGEPRWVKRFMEKGAPGAYFRVLEPGEIRAGDPVRIVHRPSHEVTVALQFRAVTTQRELLPRLLAAGGALHPEALATARKYVAEYGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O86820</accession>
    <name>END8B_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable endonuclease 8 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>DNA glycosylase/AP lyase Nei 2</fullName>
            <ecNumber>3.2.2.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>DNA-(apurinic or apyrimidinic site) lyase Nei 2</fullName>
            <ecNumber>4.2.99.18</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Endonuclease VIII 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nei</name>
        <name type="ordered locus">SCO5760</name>
        <name type="ORF">SC7C7.15c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-"/>
    <dbReference type="EC" id="4.2.99.18"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35693">
        <property type="entry name" value="T35693"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629885.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030437.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86820"/>
    <dbReference type="SMR" id="O86820"/>
    <dbReference type="STRING" id="100226.SCO5760"/>
    <dbReference type="GeneID" id="1101202"/>
    <dbReference type="KEGG" id="sco:SCO5760"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5849"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_2_0_11"/>
    <dbReference type="InParanoid" id="O86820"/>
    <dbReference type="OMA" id="TYWCPRC"/>
    <dbReference type="PhylomeDB" id="O86820"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000170902" description="Probable endonuclease 8 2">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FPG-type" evidence="2">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="3">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="3">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00392"/>
        </source>
    </evidence>
    <sequence length="276" mass="30408" checksum="01106CD65EF94DE9" modified="2007-01-23" version="3">MPEGDTVWQAARRLHDALAGRVLTRSDFRVPRYATVDLTGRTVLDVTPRGKHLLTRVEGGLTVHSHLRMDGSWKVFAPGQRWSGGPAHQIRVILGTADRTAVGYRLPVLDILRTAEEQRAVGHLGPDLLGPDWDPERALDNLRADPPRALGEALLDQRNLAGIGNVYKSELCFLLGVTPWLPVGELPADRAARLPTLAKKLLEANRDRPVRRTTGLRGQDLFVYGRAPRPCLRCGTSVRVADQGDGSRERPTYWCPTCQAGPAPRPGGRTGVRPRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-12-15" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O87838</accession>
    <name>FCTA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Formyl-CoA:oxalate CoA-transferase</fullName>
            <shortName>FCOCT</shortName>
            <ecNumber evidence="2">2.8.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Formyl-coenzyme A transferase</fullName>
            <shortName evidence="2">Formyl-CoA transferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frc</name>
        <name type="ordered locus">SCO6583</name>
        <name type="ORF">SC8A6.04c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>formyl-CoA + oxalate = formate + oxalyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:16545"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:57388"/>
            <dbReference type="EC" id="2.8.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CoA-transferase III family. Frc subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35771">
        <property type="entry name" value="T35771"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630662.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O87838"/>
    <dbReference type="SMR" id="O87838"/>
    <dbReference type="STRING" id="100226.SCO6583"/>
    <dbReference type="GeneID" id="1102022"/>
    <dbReference type="KEGG" id="sco:SCO6583"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6688"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_2_1_11"/>
    <dbReference type="InParanoid" id="O87838"/>
    <dbReference type="OMA" id="KFDIPCA"/>
    <dbReference type="PhylomeDB" id="O87838"/>
    <dbReference type="BRENDA" id="2.8.3.16">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00540">
        <property type="reaction ID" value="UER00598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033608">
        <property type="term" value="F:formyl-CoA transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00742">
        <property type="entry name" value="Formyl_CoA_transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017659">
        <property type="entry name" value="Formyl_CoA_transfer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03253">
        <property type="entry name" value="oxalate_frc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000194724" description="Formyl-CoA:oxalate CoA-transferase">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="410" mass="44664" checksum="3760A61D3D3DCAA4" modified="1998-11-01" version="1">MTAKALEGIRVLDMTHVQSGPSATQLLAWLGADVVKLEAPHGDITRGQLRDLPDVDSLYFTMLNCNKRSITLNTKSERGKEILTELIRRSDVMVENFGPGAVDRMGFTWDRVKEINPRIVYASIKGFGEGPYTAFKAYEVVAQAMGGSMSTTGFEDGPPLATGAQIGDSGTGVHVVAGILAALYQREHTGRGQRVNVAMQHAVLNLCRVKLRDQQRLSHGPLAEYPNEDFGDEVPRSGNASGGGQPGWAVKCAPGGPNDYVYVIVQPVGWQPLSELIGRPELAEDPEWATPRARLPKLNKMFQLIEEWSSTLPKWEVLERLNAHNIPCGPILSTKEIIEDDSLVANEMVVTVPHPERGEFVTVGSPLKLSDSPVEVTSSPLLGEHNEEVYVGELGLGDEELRLLKSSGVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-02-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>P19780</accession>
    <name>YIS1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Insertion element IS110 uncharacterized 43.6 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1005</name>
        <name type="ORF">2SCG2.18</name>
    </gene>
    <gene>
        <name type="ordered locus">SCO2759</name>
        <name type="ORF">SCC57A.30c</name>
    </gene>
    <gene>
        <name type="ordered locus">SCO6391</name>
        <name type="ORF">SC3C8.10</name>
    </gene>
    <gene>
        <name type="ordered locus">SCO7782</name>
        <name type="ORF">SC5E9.30</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1987" name="Nucleic Acids Res." volume="15" first="7053" last="7065">
            <title>Nucleotide sequence of IS110, an insertion sequence of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bruton C.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="2821490"/>
            <dbReference type="DOI" id="10.1093/nar/15.17.7053"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Oliver K."/>
                <person name="Harris D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (SC3C8.10)</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="submission" date="2000-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Seeger K.J."/>
                <person name="Harris D."/>
                <person name="Thomson N.R."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] (SCC57A.30C)</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="Y00434">
        <property type="protein sequence ID" value="CAB51528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A26848">
        <property type="entry name" value="A26848"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626990.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631813.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027512.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P19780"/>
    <dbReference type="SMR" id="P19780"/>
    <dbReference type="STRING" id="100226.SCO1005"/>
    <dbReference type="GeneID" id="1096428"/>
    <dbReference type="GeneID" id="1098193"/>
    <dbReference type="GeneID" id="1101832"/>
    <dbReference type="GeneID" id="1103219"/>
    <dbReference type="KEGG" id="sco:SCO1005"/>
    <dbReference type="KEGG" id="sco:SCO2759"/>
    <dbReference type="KEGG" id="sco:SCO6391"/>
    <dbReference type="KEGG" id="sco:SCO7782"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1002"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_2_3_11"/>
    <dbReference type="InParanoid" id="P19780"/>
    <dbReference type="OMA" id="KQSIHHI"/>
    <dbReference type="PhylomeDB" id="P19780"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0814">Transposable element</keyword>
    <feature type="chain" id="PRO_0000075519" description="Insertion element IS110 uncharacterized 43.6 kDa protein">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <sequence length="405" mass="43563" checksum="0D765883DC451F61" modified="1991-02-01" version="1">MFDTEDVGVFLGLDVGKTAHHGHGLTPAGKKVLDKQLPNSEPRLRAVFDKLAAKFGTVLVIVDQPASIGALPLTVARDAGCKVAYLPGLAMRRIADLYPGEAKTDAKDAAVIADAARTMAHTLRSLELTDEITAELSVLVGFDQDLAAEATRTSNRIRGLLTQFHPSLERVLGPRLDHQAVTWLLERYGSPAALRKAGRRRLVELVRPKAPRMAQRLIDDIFDALDEQTVVVPGTGTLDIVVPSLASSLTAVHEQRRALEAQINALLEAHPLSPVLTSMPGVGVRTAAVLLVTVGDGTSFPTAAHLASYAGLAPTTKSSGTSIHGEHAPRGGNRQLKRAMFLSAFACMNADPASRTYYDRQRARGKTHTQALLRLARQRISVLFAMLRDGTFYESRMPAGVELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKE2</accession>
    <name>Q7AKE2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6835</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630906.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031220.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKE2"/>
    <dbReference type="STRING" id="100226.SCO6835"/>
    <dbReference type="GeneID" id="1102274"/>
    <dbReference type="KEGG" id="sco:SCO6835"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6945"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_11"/>
    <dbReference type="InParanoid" id="Q7AKE2"/>
    <dbReference type="OMA" id="DNAKERC"/>
    <dbReference type="PhylomeDB" id="Q7AKE2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14497" checksum="A9F499E69D2B9C1C" modified="2012-05-16" version="1">MSDKPSVLFVCVHNAGRSQMAAAWLTHLAGGRVEVRSAGSTPGENVNPAAVEAMAEVGIDISAEVPKLLTADAVKESDVCITMGCGDTCPVFPGKRYLDWQLDDPAGQGVEAVRPIRDEIRVLVEGLIKEIAPEPQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKQ5</accession>
    <accession>O87598</accession>
    <name>PSB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome subunit beta</fullName>
            <ecNumber evidence="1">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prcB</name>
        <name type="ordered locus">SCO1644</name>
        <name type="ORF">SCI41.27</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5448" last="5453">
            <title>The 20S proteasome of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Nagy I."/>
                <person name="Tamura T."/>
                <person name="Vanderleyden J."/>
                <person name="Baumeister W."/>
                <person name="De Mot R."/>
            </authorList>
            <dbReference type="PubMed" id="9765579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 54-61</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>SUBUNIT</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>TEMPERATURE DEPENDENCE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The S.coelicolor proteasome is able to cleave oligopeptides after hydrophobic residues, but not after basic or acidic residues, thus displaying chymotrypsin-like activity but not trypsin-like activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1 2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity (By similarity). Peptidolytic activity is completely inhibited by lactacystin, and to a lesser extent, by N-acetyl-Leu-Leu-norleucinal (Ac-LLnL) and benzoyloxycarbonyl-Leu-Leu-Leu-vinylsulfone (Z-LLL-VS) in vitro.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <temperatureDependence>
            <text evidence="2">Optimum temperature is 55 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has probably a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is likely capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="1"/>
    <dbReference type="EMBL" id="AF086832">
        <property type="protein sequence ID" value="AAC64284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625919.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977182.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q7AKQ5"/>
    <dbReference type="SMR" id="Q7AKQ5"/>
    <dbReference type="STRING" id="100226.SCO1644"/>
    <dbReference type="MEROPS" id="T01.005"/>
    <dbReference type="GeneID" id="1097075"/>
    <dbReference type="KEGG" id="sco:SCO1644"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1659"/>
    <dbReference type="eggNOG" id="COG0638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_2_0_11"/>
    <dbReference type="InParanoid" id="Q7AKQ5"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="PhylomeDB" id="Q7AKQ5"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_0000383489" description="Removed in mature form; by autocatalysis" evidence="1 2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5000055072" description="Proteasome subunit beta">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="9765579"/>
        </source>
    </evidence>
    <sequence length="281" mass="30086" checksum="860B58A2B45CD8F8" modified="2004-07-05" version="1" precursor="true">MEANTRSTGRLPAAFLTPGSSSFMDFLGEHQPEMLPGNRQLPPVQGVIEAPHGTTIVAVTFPGGVVLAGDRRATMGNMIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVKLFQLELEHFEKVEGAQLSLEGKANRLSTMIRSNLGMAMQGLAVVPLFAGYDVDRGRGRIFSYDVTGGRSEERHFATTGSGSVFARGAMKKLFRDDLTEEQATTLVVQALYDAADDDSATGGPDVARRIYPIITVITEDGFRRLGEDEAAELAGSVLQARLEQPDGPRAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API4</accession>
    <name>Q7API4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mmyD</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639841.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039533.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095314"/>
    <dbReference type="KEGG" id="sco:SCP1.233"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8178"/>
    <dbReference type="HOGENOM" id="CLU_073081_0_0_11"/>
    <dbReference type="OMA" id="SIFCKAN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008799">
        <property type="entry name" value="Pseudomon_AvrD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05655">
        <property type="entry name" value="AvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="37307" checksum="AD23E93C373DCB16" modified="2012-05-16" version="1">MPVSGSLSQKLFHRSVDDVLGPRERRFFGEGFKRAEHRLRHIFVTYGPEGRAQADARVSVDYPSDWSRKGDADQRPHLSTVDVLVIGAQLSEVHLAHVLGLSPDQRARAVLQRVRIKAGRSPVEEDLAGFAASAQLVATIPSDRVVGLFLSTVECVVGTLRMRCEIRHEAGVPHQAAGSYDSLRGLLGDPRLRLFGEGFTSRRQLVEDVVIDPQARQAAAAVRVIRDEDAPSPATGLEGAHHDRASAIDAFVIGLQLGQVLLYTLDEVPRAQSNTLWMRETILELDPLRPPLPATAPVTTRLDRCKRLETGKGDIWRSADIVGEFLGVRLRCSVAHRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJK2</accession>
    <name>Q8CJK2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO7374</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAD55398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733731.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031619.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7374"/>
    <dbReference type="GeneID" id="1102812"/>
    <dbReference type="KEGG" id="sco:SCO7374"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7479"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_4_11"/>
    <dbReference type="InParanoid" id="Q8CJK2"/>
    <dbReference type="OMA" id="NLAWCHP"/>
    <dbReference type="PhylomeDB" id="Q8CJK2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02791">
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAD55398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="830" mass="90517" checksum="EC75AF7C88CEAAA2" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJY4</accession>
    <name>Q8CJY4_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">SCO2810</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="CAD55455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="453" mass="48084" checksum="5B7506ECAD9DF60B" modified="2003-03-01" version="1">MTVKALSASAPASFDPGAEAARATAAILHDTLHGTERGVVVDSPPGAGKSTLVVRAALELAEAGRPLMVVAQTNAQVDDLVLRLAEKNPDLPVGRLHSSDADPYDKALDALGNVRKSAKAADLAGQAVVLSTAAKWAHVKVDEPWRHAIVDEAYQMRSDSLLAVAGLFERALFVGDPGQLDPFATVGSEQWAGLAYDPSSSAVTTLLAHNPGLPQHRLPVSWRLPASAARLVSDAFYPYTPFRSGTRHGDRSLAFAVPSDGSGPDRVIDEAAASGWGLLELPARHTPRTDPEAVRAVAAVVRRLLDREGRATSERSPDPAPLTAARIAVGTAHRDQAAAVRAELAGLGVHDVTVDTANRLQGREYDVTVVLHPLSGRPDATAFHLETGRLCVLASRHRHACIVVCREGVGDLLDDYPSTEPVQLGTLVKFPDGWEANHAVLAHLAEHRAAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK59</accession>
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        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
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    </protein>
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        <name evidence="7" type="ordered locus">SCO0375</name>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
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            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAD55439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095798"/>
    <dbReference type="KEGG" id="sco:SCO0375"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.351"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q8CK59"/>
    <dbReference type="OMA" id="SFVDGWQ"/>
    <dbReference type="PhylomeDB" id="Q8CK59"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="53712" checksum="CB86231C8A95533B" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IX1</accession>
    <name>Q93IX1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1299</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625585.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977532.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1299"/>
    <dbReference type="GeneID" id="1096722"/>
    <dbReference type="KEGG" id="sco:SCO1299"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1300"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_3_1_11"/>
    <dbReference type="InParanoid" id="Q93IX1"/>
    <dbReference type="OMA" id="NYKPFHD"/>
    <dbReference type="PhylomeDB" id="Q93IX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="16331" checksum="D37B70BA1B8D0C4F" modified="2001-12-01" version="1">MTEYSPDATDWRILEALQRDGRASFAELARAVSMSASAVTERVRRLEEAGIIQGYAAVVDPERLGLPILAFVRLRYPVANYKPFHDLVAVTPEILEAHHVTGDDCFVIKVAARSMRHLEEVSGRISALGSVTTSVVYSSPLPRRPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF5</accession>
    <name>Q93JF5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO5972</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630088.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030574.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5972"/>
    <dbReference type="GeneID" id="1101414"/>
    <dbReference type="KEGG" id="sco:SCO5972"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6070"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042787_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JF5"/>
    <dbReference type="OMA" id="AKHYWVA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024026">
        <property type="entry name" value="3'-RNA_MeTfrase_Hen1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024740">
        <property type="entry name" value="Hen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038546">
        <property type="entry name" value="Hen1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="PTHR21404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12623">
        <property type="entry name" value="Hen1_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04074">
        <property type="entry name" value="bacter_Hen1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hen1_L" evidence="10">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_12" evidence="9">
        <location>
            <begin position="335"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC44586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="531" mass="58657" checksum="714F1033D5C29B3F" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD79</accession>
    <name>Q9AD79_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4929</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629082.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029955.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4929"/>
    <dbReference type="GeneID" id="1100370"/>
    <dbReference type="KEGG" id="sco:SCO4929"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5008"/>
    <dbReference type="eggNOG" id="ENOG5030G8T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101000_0_0_11"/>
    <dbReference type="OMA" id="DRATHTD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="221" mass="21600" checksum="5EDE3A6C31AFCE89" modified="2001-06-01" version="1">MTTTGTPTEPRYAWGRRGRHRRPRPRKVLLAAGGLALAAGALSVVRLLPGPGGDTGGVRAGAEPRVESGGRDPSPDPATAPAAGTVGEPSGAGPSATSAMGGLSGSPGPGLIPGLAPAPSATGPAVPLPTAPPVRTPGAPETPKPGEGAGERERERGDDTGERAPAPGTPQPSRSDRPVPHPVPPPPPGPGTPPPSDPAPEPADPGLCVPVIGLCVDLLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADH9</accession>
    <name>Q9ADH9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6084</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630192.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030642.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6084"/>
    <dbReference type="GeneID" id="1101525"/>
    <dbReference type="KEGG" id="sco:SCO6084"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6186"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_5_0_11"/>
    <dbReference type="InParanoid" id="Q9ADH9"/>
    <dbReference type="OMA" id="RQIEWYA"/>
    <dbReference type="PhylomeDB" id="Q9ADH9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="26700" checksum="CA300BED24D15C63" modified="2001-06-01" version="1">MGWHRELLIGFDLETTGTDPREARIVTGAVIEVRGSEPLGRREWLADPGVEIPADAVAVHGISNERAAREGRPADQVADAIATVLVDHWKAGVPVVAYNAAFDLTLLAAELRRHALPSLRERLGGLDPAPVIDPYTIDRSVDRYRRGKRNLEAVCREYGVRLDAAHDATADALAAARLACAIADRHPKVAALGPADLHRRQIEWYAEWAADFQSFLRRKGDATAVVDGTWPLRESAGEPADERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN0</accession>
    <name>Q9ADN0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4028</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628210.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029393.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4028"/>
    <dbReference type="GeneID" id="1099464"/>
    <dbReference type="KEGG" id="sco:SCO4028"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4091"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074354_2_0_11"/>
    <dbReference type="OMA" id="AERPHAF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="273" mass="29524" checksum="59F5A64B64998C79" modified="2001-06-01" version="1">MLFVLCSQSGMCCGALLRTAVRPRLPKRFVVAASEFPDLPRFPVGFELAEALTAAAGDLHATGSPGDTMNTAVALAVRLLPEAEHAGISEIQRGGRLRSLAWTDETVRFAAEPRQGGHTPHPDWERLWTTPVVRTDDSEADGGGSVLSGLGLRSTLSLRLRADRRRLTVLTAYARKPQAFDEDATRIGRLFTAHVSLALDSATVREQLTEAMRTRDLIGQATGILMERLDIDAGGAFESLVKASQRENVKLRDLARRIVDANSGAGGRGVTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADN8</accession>
    <name>Q9ADN8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gntR family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4019</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628201.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029386.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4019"/>
    <dbReference type="GeneID" id="1099455"/>
    <dbReference type="KEGG" id="sco:SCO4019"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4082"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_3_11"/>
    <dbReference type="InParanoid" id="Q9ADN8"/>
    <dbReference type="OMA" id="RYRHLWL"/>
    <dbReference type="PhylomeDB" id="Q9ADN8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="25766" checksum="ED3BBBC83362ADF5" modified="2001-06-01" version="1">MTQTAPTSPQSPPPAGKRMLSEQVYAHLRDAIMRGDHTPGAALKPQDLAKEQGVSLAVVREALVRVVGDGLADRLPNRGFAVPAYSDRRWQEIAEARRTIEPVLLRMSVERGDVDWEARVRAAHHRLSRTPPYTPEEGEYYSEAWSEAHRLFHRALMEGCGNPVLLETFDRLWTASELARRWSTHRNPGRDGVEEHRRLEEAALARDADTAAEVLVRHLTLTAEGLTAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK33</accession>
    <name>Q9AK33_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4893</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629046.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029931.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4893"/>
    <dbReference type="TCDB" id="2.A.69.3.1">
        <property type="family name" value="the auxin efflux carrier (aec) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1100334"/>
    <dbReference type="KEGG" id="sco:SCO4893"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4973"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_2_2_11"/>
    <dbReference type="InParanoid" id="Q9AK33"/>
    <dbReference type="OMA" id="TTFFWTL"/>
    <dbReference type="PhylomeDB" id="Q9AK33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="307" mass="30970" checksum="6CC4393EFB9A45CC" modified="2001-06-01" version="1">MQGVLTGFAVIAVVIGVGYVLGLRGHLGPQGREVLTKLAFHVASPALLFTTLATADLSVVFSARLLVTALSTLAVAGAFVAVGVVRGWGVGRTTIGALCSGYVNSGNLGIPIAVYVLGDASLVAPVLLFQLVLVTPVAVTILDLSSGGGAEGPLWRRLLTPLRNPIALGSLAGVAVAASGFEVPDPVMDPITLIGNMSVPAVLLAFGIGLCGSTMPLRGVERRPVLLAVALKAVGQPAVAWALASGVFGLRGPQLLDVVVTSALPAAQNLYTYASTYGVGERLARDAILVSTVVSVPVLVGVAAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK97</accession>
    <name>Q9AK97_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625649.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977461.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1365"/>
    <dbReference type="GeneID" id="1096788"/>
    <dbReference type="KEGG" id="sco:SCO1365"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1373"/>
    <dbReference type="eggNOG" id="ENOG502ZVZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177097_0_0_11"/>
    <dbReference type="OMA" id="WHCHDES"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="55" mass="6333" checksum="4E9882B298F5CBAA" modified="2001-06-01" version="1">MALPAVDGRQYVYRVDAPAEALLADLFWEAWHCHDESAFPRAWDVFDAAVIRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWH4</accession>
    <name>Q9EWH4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1656</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC18787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625931.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977169.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1656"/>
    <dbReference type="GeneID" id="1097087"/>
    <dbReference type="KEGG" id="sco:SCO1656"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1673"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_1_11"/>
    <dbReference type="InParanoid" id="Q9EWH4"/>
    <dbReference type="OMA" id="HTLDDSW"/>
    <dbReference type="PhylomeDB" id="Q9EWH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC18787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="24503" checksum="692A1A91C3F4F06E" modified="2001-03-01" version="1">MTSTVPALGTRTAEGSALQAVLLDMDGTLVDTEGFWWDVELEVFASLGHTLDDSWRHVVVGGPMTRSAGFLIEATGADITLAELSVLLNDGFEQRIGRDLPLMPGAARLLAELSAHEIPTALVSASHRRIIDRVLTSLGPRHFALTVAGDEVPRTKPHPDPYLAAAAGLGVDPARCAVVEDTATGVAAAEAAGCHVVAVPSVAPITPAARRTVVASLEEVDLTFLRGLMTQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWM7</accession>
    <name>Q9EWM7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7762</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631795.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031889.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7762"/>
    <dbReference type="GeneID" id="1103199"/>
    <dbReference type="KEGG" id="sco:SCO7762"/>
    <dbReference type="HOGENOM" id="CLU_075312_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="34059" checksum="B9EADB1679C1C6D7" modified="2001-03-01" version="1">MQRLLKVSGTNTPIVVGDEFGRSGRVSASSENVLDLGRLGQRMQVGGACRSHRCPSRLARSRSVRALGCRECRPRSVAQSLPSLTTSSELPRGVDSVSRPQVVRLIALEHLEHRFRARCSERGDLTKILLAQNDPARFPCHDSILDHCAGQPGGRGGSGCSIPTGSPPHRILQSHQLCPVCRRSFRPRTDLYINNRATRAFGPGCGRSSLAGSRPAVFQRAGAGSESGALTAGRSRRAGAGGAPGDAIAAPTRSAPAPFSPLTQLTGDVRAAHLEGRSVAALARDHRSGRDRMTRPWLHPARLSNEPAPGVPDLARSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWR7</accession>
    <name>Q9EWR7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0785</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625087.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027354.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0785"/>
    <dbReference type="GeneID" id="1096208"/>
    <dbReference type="KEGG" id="sco:SCO0785"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.777"/>
    <dbReference type="HOGENOM" id="CLU_1219127_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="22856" checksum="B8A7424409FB4B41" modified="2001-03-01" version="1">MPGEPRVPAHSCPVLPRPGHSGGGAAARRRRPSLARGLDGGEAGTTVAKGVLVRSRRTLLAAAVVLAAGVGATLWGLMTGPLRRRAAALNLSSVPALGAAVVVAVGVTTGPGRAWSSRWSSGRCWSAATWSPPGRSWAGGRRAAVTEAVIVLALLLVALSATAVVAVRDPVRQSLVPAVLGVVLAVLFAVPQAPRGVAPGRHRPAGRAGPPRCAVRVSRAAPTADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWU0</accession>
    <name>Q9EWU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625035.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027320.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0731"/>
    <dbReference type="GeneID" id="1096154"/>
    <dbReference type="KEGG" id="sco:SCO0731"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.721"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_2_11"/>
    <dbReference type="InParanoid" id="Q9EWU0"/>
    <dbReference type="OMA" id="IWRADEI"/>
    <dbReference type="PhylomeDB" id="Q9EWU0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="106"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="393" mass="41565" checksum="DEA28D5AF32EC6C7" modified="2001-03-01" version="1">MTSNPWDQAGEPNPLRALTPDQLRRRTSMKWRTHPADVLPLWVAEMDVPLARPVVRAVTEAMELGDTGYPVGTAYAEALAAFAAKRWGWDGLAVERTAIVPDVMLGVVEMLKLVTGPGDPVIVNPPVYPPFYQFVTHMDRRVVEAPLGPDLRIDLGVLEAVFRRAVAGGGRAAFLLCSPHNPTGTVHTAEELAAVAALAERYGVRVVADEIHAPVVTAPDARFVPYLGVPGAERGLSLMSASKGWNLAGLKAALAVAGPGAAADLARMPEEVGHGPSHIGVLAHTAALRDGTAWLDAVLAGLDENRRLLTGLLAERLPGVVHRAGEATYLAWLDCRALGLGDEPADVFLDRGRVALSSGVPFGSGGPGHVRLNLATSPEVLTEAVRRMAAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2K3</accession>
    <name>Q9F2K3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3778</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627968.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029229.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3778"/>
    <dbReference type="GeneID" id="1099214"/>
    <dbReference type="KEGG" id="sco:SCO3778"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3838"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_2_1_11"/>
    <dbReference type="InParanoid" id="Q9F2K3"/>
    <dbReference type="OMA" id="QIDFHQP"/>
    <dbReference type="PhylomeDB" id="Q9F2K3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="54"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC10316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="430" mass="47915" checksum="4A905C49A7E33084" modified="2001-03-01" version="1">MVLVPWTVPRETTVHDRNHARSHDRDHDHRRLGRELALFDTDPLMGAGLPYWLPDGAVVRHTLEEYVREAERRAGYRHVYSPVLGKRELYEISGHWEHYRDDMFPPMELGAEEVVLRPSLCPHHALVYRSRARSYRELPLRIAELGAMYRSEPSGVLGGLSRVRAIHLNDAHIFCTPDQAAAEARAALGLIRRAHADLGIRAARHRLSLPGPGGKYVADPELWRRATALLEEALDGLPYEAVEGEAAFYGPKIDVQIEDAAGRESTLSTVQIDFHQPERFGLRYLGPDGARHRPVMVHRSVIGSVERAVAHLIEAHGGAFPAWLAPVQLVVLPVAGAQREAAYALVRQATDLGLRAEVADPERGSLGARVRAARKVPYQAVIGVREAQDGDLVDVRLRDGRRPGQLSGTELLHRITDRVEARGPELWPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2L5</accession>
    <name>Q9F2L5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3766</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627956.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3766"/>
    <dbReference type="DNASU" id="1099202"/>
    <dbReference type="GeneID" id="1099202"/>
    <dbReference type="KEGG" id="sco:SCO3766"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3825"/>
    <dbReference type="eggNOG" id="COG4326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057336_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2L5"/>
    <dbReference type="OMA" id="YGHHEVH"/>
    <dbReference type="PhylomeDB" id="Q9F2L5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC10304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="34977" checksum="AFA6BC2EFB0C02F8" modified="2001-03-01" version="1">MLLLACREQPAGSGCSPHEREGENASMVFKRLLGSLGVGGPTVDTTLAPGAARPGGTLSGRVRLVGGTVGHDVEHVALELVARVETGDGEHGDGEGVVVFGRHTVGGPFRLAAGEETSIPFTVTLPWETPATELYGRQLGVVLGVRTELAVAGARDSGDPDPFAVAPLPAQEAVLEALGRLGCGFRSAGLEYGRIGGTGQQLPFHQEIELTPPPRYAHQADEIELTFLAVPGALEVVLEADKRGGPLSDGHGGHDALSRFTVPHEGPAGPRDWTALVDGWMRELVEHRASYGSHAVYGHDAGVGAPVMAGAAGIAGGMVAAEVVDEAGDFFEGDSGDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2P4</accession>
    <name>Q9F2P4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3106</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627324.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028770.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3106"/>
    <dbReference type="GeneID" id="1098540"/>
    <dbReference type="KEGG" id="sco:SCO3106"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3169"/>
    <dbReference type="eggNOG" id="ENOG50337FI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061390_0_0_11"/>
    <dbReference type="OMA" id="KGECAGT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176661" evidence="2">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC09547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="30430" checksum="13A1DA979A27CF9B" modified="2001-03-01" version="1">MRRRARRTALTALLLAAGATACLTGCQSGQDGDGASDGAARSAASGGSSAASPSATAPGSTAAPAEASASAPAPSPDEPFAGLSGAEISERALKATTGARSLRMTGSVPDDESGDTIEIDLALDRRGDCAGTMGMDGQGEAELIKTGDTVYLKYDERFLRAQSKGEPQADTEALVSLLAGRWTSMSADGADAKEMAGFCDLDKLLEDAGGSGDDAPTKVTRGRATTVDGKPAFTLYETDGSVRNTVYVATEGKPYLLRFESGSKQEPGALSFTGYDEPVPAEPPSGEVLDLDSPDGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F319</accession>
    <name>Q9F319_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627989.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975142.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3799"/>
    <dbReference type="GeneID" id="1099235"/>
    <dbReference type="KEGG" id="sco:SCO3799"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3866"/>
    <dbReference type="eggNOG" id="ENOG5033PZR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1676798_0_0_11"/>
    <dbReference type="OMA" id="KVYCPRG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="2">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="17400" checksum="C74BFE3EB4398590" modified="2001-03-01" version="1">MYGYDQTAGQQQQQYAPPPQQPMGGGYGQQPPLYPEPSPPSLADAVRAFTTGQMSAEDFQQIFATSKVYCPRGDNPGFLALHNTQQPVIPMFTGLKELRRYAGKESKYFVITGAEVIDLLPTGYGFVLDMEGEHRMVFDAKAVEQMVDFAMRRMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F339</accession>
    <name>Q9F339_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5131</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629280.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030073.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F339"/>
    <dbReference type="STRING" id="100226.SCO5131"/>
    <dbReference type="GeneID" id="1100572"/>
    <dbReference type="KEGG" id="sco:SCO5131"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5214"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_8_11"/>
    <dbReference type="InParanoid" id="Q9F339"/>
    <dbReference type="OMA" id="WRIALGW"/>
    <dbReference type="PhylomeDB" id="Q9F339"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="40670" checksum="D56DB924BBA65243" modified="2001-03-01" version="1">MSGVGIGQRPENRRQKTVKVMWTAIWLAYLGAPVSDLLHGGHAVGVQVLGWIGLVAFVVWYMLLLFRTGRGERTRLVLGSLAVLAAESTLLALTLGREWLVLFVYVAIASGAALPLRLARWTIPGASALLTAMALVVPGGTSFIAGLLLPALLGGFAMTGVRELVRTTIALREARATVAQLAANEERLRLARDLHDLLGHSLSLITLKSELAGRMLPAHPDKAAQQVADIEQVSRQALVDVREAVTGYRRARLAPELAGAKVALTAAGVDAELPGEPDPAHLPEDSEAALAWALREAVTNVVRHSGARRCVVELLERQTLDGAVLELSVEDNGSGGPASANAPGNGLTGLAERLEKAGGTLEAGGSRRGFRLVARVPVGAATDVGSGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-02" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F344</accession>
    <name>MSHB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="1">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="1">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mshB</name>
        <name type="ordered locus">SCO5126</name>
        <name type="ORF">SC9E12.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Mol. Microbiol." volume="68" first="861" last="870">
            <title>Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and sigma(R) in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Park J.H."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="18430082"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06191.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Gradually induced by thiol-oxidant diamide, under (probably indirect) control of SigR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MshB deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629275.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030070.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F344"/>
    <dbReference type="SMR" id="Q9F344"/>
    <dbReference type="STRING" id="100226.SCO5126"/>
    <dbReference type="GeneID" id="1100567"/>
    <dbReference type="KEGG" id="sco:SCO5126"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5209"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_2_1_11"/>
    <dbReference type="InParanoid" id="Q9F344"/>
    <dbReference type="OMA" id="YWNRVPR"/>
    <dbReference type="PhylomeDB" id="Q9F344"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000400226" description="1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18430082"/>
        </source>
    </evidence>
    <sequence length="295" mass="31433" checksum="0EBA7027EF891ED8" modified="2001-03-01" version="1">MTDLPGRRLLLVHAHPDDESINNGVTMARYAAEGAHVTLVTCTLGERGEVIPPALAHLSGAALGGHRRGELADAMRALGVDDFRLLGGPGRYADSGMLGLSDNDDPGCLWQADVDAAAALLVDVIREVRPQVLVTYDPNGGYGHPDHIQAHRIAMRAAELAAEAGCPVAKVYWNRVPRSRVEDAFARLRDDLPGLPFEKAAGVEDVPGVVDDERITTEIRGEGTAYAAAKAAAMRAHATQITVAEPYFVLSNDLAQPILTTEYYELVRGERGGEGRENDLFAGIAGTFDTGEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F379</accession>
    <name>Q9F379_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4409</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628577.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974573.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4409"/>
    <dbReference type="GeneID" id="1099849"/>
    <dbReference type="KEGG" id="sco:SCO4409"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4477"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_5_11"/>
    <dbReference type="InParanoid" id="Q9F379"/>
    <dbReference type="OMA" id="WDRKMQQ"/>
    <dbReference type="PhylomeDB" id="Q9F379"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC08418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="21875" checksum="5DEA88371F7A4F87" modified="2001-03-01" version="1">MAKRDVPPRWDRKMQQRLARGEAAALGELYDRFASLVHGLAHRVLDDERAADHITRDVFAHVWEHPDAYDPRQGPLRTWIATLTHRFAVQRLRATETAALVRGGAGTAEELETKVRHASVAARADYIVQSMPAPLRAALELAYFQRRDYRQTAADLGVTEDEARRRLRLGLQLLSTARDAGTAQHPPGAPPGYGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3B5</accession>
    <name>Q9F3B5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative MutT-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7560</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631603.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971584.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7560"/>
    <dbReference type="GeneID" id="1102998"/>
    <dbReference type="KEGG" id="sco:SCO7560"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7674"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_9_1_11"/>
    <dbReference type="InParanoid" id="Q9F3B5"/>
    <dbReference type="OMA" id="GHDGRWE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC16440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="18278" checksum="A1751E6CAC304AAC" modified="2001-03-01" version="1">MNSSAPGAERPERARPAAQSLTGVGLAVLDPAGRVLLGLGHDGRWELPGGKVDAGEDFETAAARELAEETGLVAAPAEVRVLAVLVDGVGGLTRVTAAAVTGRAAGTPRVTEPDKIERWEWFARESVPSALFPPSASVLDCLWPAAQRRGADGVRHYAVAGPAVKGRTSPDGRAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3I5</accession>
    <name>Q9F3I5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cellobiose transport permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2796</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627026.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028590.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2796"/>
    <dbReference type="GeneID" id="1098230"/>
    <dbReference type="KEGG" id="sco:SCO2796"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2854"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_11"/>
    <dbReference type="InParanoid" id="Q9F3I5"/>
    <dbReference type="OMA" id="THILVTY"/>
    <dbReference type="PhylomeDB" id="Q9F3I5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="37652" checksum="3FD3CC533C69B203" modified="2001-03-01" version="1">MTTRHDTAASPVKGGAAPGRPPGGRASAEADRRKRAKLSRRWQRDMRWSPYAFVSPFFLLFLAFGLFPLIYTGWASLHTVELTAPTDMQWTGLDNYTRIFDDEFFWNAAKNTLWIGVISTVPQLLMAMGLAHILNYKLRASTFYRVVMLAPYATSIAAASLVFVLLFGRDYGMINWVLDLVGLDKIDWQNGSWSSKFAVSTIVIWRWTGYNALIYLAAMQAIPQDLYESAALDGASRWRQFIHVTLPSLRPTILFTVVVSTIGASQVFGEPLLFDANKGASGGSQHQFQTLGLYLYEQGWVNQHLGRASAIAWAMFLILIVIGVLNAVISRRLRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBJ3</accession>
    <name>Q9FBJ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5165</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629313.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030092.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5165"/>
    <dbReference type="ESTHER" id="strco-SCP8.28C">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1100606"/>
    <dbReference type="KEGG" id="sco:SCO5165"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5248"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_23_0_11"/>
    <dbReference type="InParanoid" id="Q9FBJ3"/>
    <dbReference type="OMA" id="RGQYESD"/>
    <dbReference type="PhylomeDB" id="Q9FBJ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046503">
        <property type="term" value="P:glycerolipid catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="32178" checksum="A072C9C344405AE5" modified="2001-03-01" version="1">MSRNAAFSPPPSARAYRLRTARGEFAVVDSPAAAGVAPRGVVMMLPGFTGSKEDFTLLHRPLGARGYRTVAVDGRGQYESDGPEHDESAYARPELARDVLAQAAALGTRVHLVGHSLGGQIARAAVLLDPAPFLSLTLMSSGPARISESQRQRVKLLRDALDTMTMAEVWEVMQAMGPPEEAGAPAPAHGPEDRVRLRDRWLGTRPAQLLATGGQLCTEPDRVAELAAVPLPFHVLSGTYDDTWPVPLLDEMALRLDARRTVVAGAEHSPNTDQPLPTARALADFWDDHPVPPRPYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC30</accession>
    <name>Q9FC30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7054</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631116.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031405.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7054"/>
    <dbReference type="GeneID" id="1102492"/>
    <dbReference type="KEGG" id="sco:SCO7054"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7158"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_1_4_11"/>
    <dbReference type="InParanoid" id="Q9FC30"/>
    <dbReference type="OMA" id="ANFWMAT"/>
    <dbReference type="PhylomeDB" id="Q9FC30"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="93"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="21873" checksum="4301D0D45C204EFD" modified="2001-03-01" version="1">MSLKYAVLAALLEGEASGYELSKVFDVSLANFWPATPQQLYRELERLAGDGLIEARTVPQERRPTKRLFSLTEAGREQLGVFAAAPTRRPTAIRDEFLIKMQAMDGVDPAAVRALVEERRAWALGKLARYERVRERLLDGRTEEEHLRDADRVGPYLTLAAGITFERENARWCERVLAVLDERRAPAGPAGQPLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC37</accession>
    <name>CRCB2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative fluoride ion transporter CrcB 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crcB2</name>
        <name type="ordered locus">SCO7046</name>
        <name type="ORF">SC4G1.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631108.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031399.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FC37"/>
    <dbReference type="SMR" id="Q9FC37"/>
    <dbReference type="STRING" id="100226.SCO7046"/>
    <dbReference type="GeneID" id="1102484"/>
    <dbReference type="KEGG" id="sco:SCO7046"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7150"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_1_11"/>
    <dbReference type="InParanoid" id="Q9FC37"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="PhylomeDB" id="Q9FC37"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903424">
        <property type="term" value="P:fluoride transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000110193" description="Putative fluoride ion transporter CrcB 2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <sequence length="124" mass="12636" checksum="FFBCD2CA00081E6D" modified="2001-03-01" version="1">MNWLLVVAGGMIGAPLRYLTDRAVQSRHDSVFPWGTFTVNVIGSVVLGLLTGAALAGAVGSDLRLLLGTGLCGALTTYSTFSYETLRLTETGARLHAAVNVGGSVAAGLVAAFAGVTLADALWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCB7</accession>
    <name>Q9FCB7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1250</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625538.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027669.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1250"/>
    <dbReference type="GeneID" id="1096673"/>
    <dbReference type="KEGG" id="sco:SCO1250"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1250"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_1_11"/>
    <dbReference type="InParanoid" id="Q9FCB7"/>
    <dbReference type="OMA" id="IAGFDGW"/>
    <dbReference type="PhylomeDB" id="Q9FCB7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="15881" checksum="BAA2021D4D260CAA" modified="2001-03-01" version="1">MTDLLVRPAVADDLDAVLAFWKTAAEGTSISDDRDGVERLVARDPEALLLAEREGELVGTVIAGFDGWRCHLYRLAVHPDHRRRGIGSALLTAADERFVRLGGRRGDAMVLVRNEQAQHAWRAAGYEPQEQWRRWVKHLTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCD3</accession>
    <name>URE11_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease subunit alpha 1</fullName>
            <ecNumber evidence="1">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Urea amidohydrolase subunit alpha 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureC1</name>
        <name type="ordered locus">SCO1234</name>
        <name type="ORF">2SCG1.09c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="1">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625522.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977597.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCD3"/>
    <dbReference type="SMR" id="Q9FCD3"/>
    <dbReference type="STRING" id="100226.SCO1234"/>
    <dbReference type="GeneID" id="1096657"/>
    <dbReference type="KEGG" id="sco:SCO1234"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1233"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCD3"/>
    <dbReference type="OMA" id="GFDSHIH"/>
    <dbReference type="PhylomeDB" id="Q9FCD3"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000234187" description="Urease subunit alpha 1">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Urease" evidence="1">
        <location>
            <begin position="136"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <sequence length="573" mass="60551" checksum="EE035EEA30B18456" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J4</accession>
    <name>Q9K3J4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4826</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628982.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029891.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4826"/>
    <dbReference type="GeneID" id="1100267"/>
    <dbReference type="KEGG" id="sco:SCO4826"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4902"/>
    <dbReference type="eggNOG" id="ENOG5033XVA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027956_0_0_11"/>
    <dbReference type="OMA" id="GYSKTSW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021224">
        <property type="entry name" value="DUF2690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10901">
        <property type="entry name" value="DUF2690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB97429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="498" mass="49567" checksum="B87FA93147BE992B" modified="2000-10-01" version="1">MGSQKRVPRGGTPRAGTSGETTSTSPGEEGEAVPRWKALPEELDPQIREFTSQLRRLVDRSELSVASVADATGYSKTSWERYLNGRLLAPKGAIVALAEVTETNPVHLTTMWELAERAWSRSEMRHDMTMEAIRISQARAALGELGTPAARSGGAAAKSGHGGRTGKGSRTGRHGGGTSAASGIAGPAGVSPTLPPTVPAQPTAADSPDSALGAGRDGGAPGVSSAPSPGGATDGNSWGLAGYRGPAPTGDRTARSGVRPGTEEPVGPAGPAGPHGPGPAGAYDEPRSDAYGGPRPDAYGGTRSDAYGESPSDAYGEPPHGGASASRRTPPGGGGNKRVTTVIAGVVGVLVVIAGAFFLLRDGGDKKNEGTKPSPSPTVSSEPKLPPGVKCSGDACTGKDPEAMGCGGDLVTTGATAVVGTAAVEVRYSEVCGAAWARVTQAAQGDEVQVSAGGAGEQRATVGTVGSTVAYTPMVAVKSAADATACATLAAGTQGCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Z7</accession>
    <name>Q9K3Z7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ordered locus">SCO1336</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625621.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027728.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1336"/>
    <dbReference type="GeneID" id="1096759"/>
    <dbReference type="KEGG" id="sco:SCO1336"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1342"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_2_0_11"/>
    <dbReference type="OMA" id="YVALVPW"/>
    <dbReference type="PhylomeDB" id="Q9K3Z7"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="219"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB95793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="524" mass="56224" checksum="9D14446FD9049489" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K405</accession>
    <name>Q9K405_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625613.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027724.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9K405"/>
    <dbReference type="STRING" id="100226.SCO1328"/>
    <dbReference type="GeneID" id="1096751"/>
    <dbReference type="KEGG" id="sco:SCO1328"/>
    <dbReference type="HOGENOM" id="CLU_976308_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="30886" checksum="E88276618ACFE605" modified="2000-10-01" version="1">MTTPPAQGRTHVTRRPAPFAMDPDQNTGADVVLYAISDHTSTAVVTLASLRAFAARQGFNVVHEVYDLTSLHVPARRRAGWRTVERVITSRRAAGLVAPAANHISAVPAQQSALRRWLLSVSAFAAYLDDVRKTAHRRPVAADRLERHQSYTCSPNELGTLRNDARTHLTLVGWPGDLATAIQVLTCLTHIPVARAPLAGTASSAAILRLTVTEREELVIELQAPQACTDRAAASLTARSLTQARLLGAEISCGLSDGARATTVRARLRPSSPDHRVRSAGRRWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K407</accession>
    <name>UPPP2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase 2</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP2</name>
        <name type="synonym">bacA2</name>
        <name type="synonym">upk2</name>
        <name type="ordered locus">SCO1326</name>
        <name type="ORF">2SCG61.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625611.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977503.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K407"/>
    <dbReference type="SMR" id="Q9K407"/>
    <dbReference type="STRING" id="100226.SCO1326"/>
    <dbReference type="GeneID" id="1096749"/>
    <dbReference type="KEGG" id="sco:SCO1326"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1330"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K407"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="PhylomeDB" id="Q9K407"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000151212" description="Undecaprenyl-diphosphatase 2">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="291" mass="31437" checksum="AB24C9578D4E1F51" modified="2000-10-01" version="1">MSWFESLVLGLVQGLTEFLPVSSSAHLRLTAAFSGWHDPGAAFTAITQIGTEAAVLIYFRKDIGRIIAAWTRSLTDKSMRHDPDARMGWLVIVGSIPIGVLGLTLKDQIEGPFRDLRITATMLIVVGVIIGIADRMAARDEKGGRHRAPQQRKELENLGVRDGLIYGLCQAAALIPGVSRSGATISGGLFMGYRREAAARYSFLLAIPAVLASGVFELKDAMESDHVSWGPTLFATVIAFATGYVVIAWFMKFISTKSFMPFVWYRIALGIVIIVLVSVGVLSPHAAESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K420</accession>
    <name>Q9K420_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1079</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625373.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977751.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1079"/>
    <dbReference type="GeneID" id="1096502"/>
    <dbReference type="KEGG" id="sco:SCO1079"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1076"/>
    <dbReference type="eggNOG" id="ENOG5033322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087610_0_0_11"/>
    <dbReference type="OMA" id="LLYPGAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="29545" checksum="6510A6C00951F359" modified="2000-10-01" version="1">MSRPPGEDRTLRALGLAGVPREEPLLYPGAWPRESGLLDGDRLLPLDRPVYDEEDGRVPVLAIGSNASPAQLRHKMAEFGIDSPIPMVRSRVTGLDIGVSAHVSRMGYVSASPVGAPGTVRELFVLWLDAEQLAVIDASEGVPMAGGNFDRVWLPAPDVRVEPGDGSVLGGAYAYVNRHGVLHDGTGAPRRHPGAQRPLITELLHGSARLRELFGATPEEFSARARADRRLCDRGTRLFAEEGRVTASGLERYVGSGPQDPFAGSRTPSAGPTAPTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXS1</accession>
    <name>RPOZ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase subunit omega</fullName>
            <shortName>RNAP omega subunit</shortName>
            <ecNumber>2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpoZ</name>
        <name type="ordered locus">SCO1478</name>
        <name type="ORF">SC9C5.02c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="42" first="1007" last="1020">
            <title>Defining the disulphide stress response in Streptomyces coelicolor A3(2): identification of the sigmaR regulon.</title>
            <authorList>
                <person name="Paget M.S.B."/>
                <person name="Molle V."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="11737643"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02675.x"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625758.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977348.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXS1"/>
    <dbReference type="SMR" id="Q9KXS1"/>
    <dbReference type="STRING" id="100226.SCO1478"/>
    <dbReference type="GeneID" id="1096904"/>
    <dbReference type="KEGG" id="sco:SCO1478"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1487"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125406_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KXS1"/>
    <dbReference type="OMA" id="QHADSKY"/>
    <dbReference type="PhylomeDB" id="Q9KXS1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000128990" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11737643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="90" mass="9709" checksum="5B5D87917F06A832" modified="2000-10-01" version="1">MSSSISAPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGLLTSEAIEGPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU2</accession>
    <name>Q9KXU2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4299</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628471.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029564.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4299"/>
    <dbReference type="GeneID" id="1099739"/>
    <dbReference type="KEGG" id="sco:SCO4299"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4367"/>
    <dbReference type="eggNOG" id="ENOG5031XRC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107643_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12339" checksum="A39C7F0B5A0EDF89" modified="2000-10-01" version="1">MTFRGLLLGLFAVPVVVGGYFLTGAATADGTPQCDGIIEEYGDAERSGPMKPGETCDLYDFTDGRSAGTRTYEQQRKAQEEGAADGYRTGGWWLAYGVAGLTVVTVHLGLKRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXU3</accession>
    <name>Q9KXU3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4298</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628470.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029563.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4298"/>
    <dbReference type="ESTHER" id="strco-SCD95A">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="GeneID" id="1099738"/>
    <dbReference type="KEGG" id="sco:SCO4298"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4366"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_11"/>
    <dbReference type="InParanoid" id="Q9KXU3"/>
    <dbReference type="OMA" id="WLTVNVW"/>
    <dbReference type="PhylomeDB" id="Q9KXU3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB93058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="513" mass="54062" checksum="E731F4F0A9B4B93C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH2</accession>
    <name>Q9KYH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosinase (Monophenol monooxygenase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2700</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626934.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976100.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KYH2"/>
    <dbReference type="STRING" id="100226.SCO2700"/>
    <dbReference type="GeneID" id="1098134"/>
    <dbReference type="KEGG" id="sco:SCO2700"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2755"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KYH2"/>
    <dbReference type="OMA" id="NHNRVHR"/>
    <dbReference type="PhylomeDB" id="Q9KYH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase_Cu-bd" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="288" mass="33104" checksum="0C1ECA3B345852ED" modified="2000-10-01" version="1">MAYTRKDVSTLTRTEKRRFVNALLEIKRRGEYDEFVRTHIEYYVSDGENGLRTAHMAPSFLPWHRRFLLDLEEALRRVDPSVTVPYWDWTKDRSAKSAPWTADLLGGTGRRSDHRVTTGPFAHAGGNWTIKVNVTDTEYLTRDLGRAADPLGLPTKSDLEWALDDPKYDTSPYDSTVRKGFRNKLEGWGAGRGSVSWRNHNRVHRWVGGAMVGGASVNDPVFWLHHAFIDLQWSRWQARHRGARYLPAEPPGRGSAQRGRIVARHEKLPPWDVTPDELEDVGRIYRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYS9</accession>
    <name>Q9KYS9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5686</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629814.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030391.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5686"/>
    <dbReference type="GeneID" id="1101125"/>
    <dbReference type="KEGG" id="sco:SCO5686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5775"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035417_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYS9"/>
    <dbReference type="OMA" id="ILYHQQP"/>
    <dbReference type="PhylomeDB" id="Q9KYS9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176776" evidence="1">
        <location>
            <begin position="24"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB91122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="561" mass="60479" checksum="6B22BA26EFC61333" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ55</accession>
    <name>Q9KZ55_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO7076</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631138.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031417.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7076"/>
    <dbReference type="GeneID" id="1102514"/>
    <dbReference type="KEGG" id="sco:SCO7076"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7182"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="InParanoid" id="Q9KZ55"/>
    <dbReference type="OMA" id="KWSPADQ"/>
    <dbReference type="PhylomeDB" id="Q9KZ55"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="249"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB89748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="483" mass="51164" checksum="74A47321CAD2BDD8" modified="2000-10-01" version="1">MSRTAGRGPRRLIRWWRRRSLRARLTVIAATAIAVSVFVAFQVASELLAWQLRDTVEEQLRADARVLAANAERAGPAQVELPPYPGSGQLVRVILPDGSIRTPAGQPVLPPVSENAGRVARGTSADLLESNGGDEEGYAIYTLRAGDGAVQVARAVDDGPVNQFGFGMLLIGLLCVAGGALVGRTVARTGLAPIDRLTSAAVRVAHTRELDADIPDEGGGEIRRLIQSINDMLAALRDSRQAQRLLAEDAAHELKTPLTSLRLNVELLIRLDRRGTLDSALPAESRTRLLNDLGAQVAELSTLVAELTDLARGDVSDESTEVLDFADVVAAAATRAESRMPDIEVALDVTSVWVNGRPAALERAVLNLIDNAGKWSPADQPVQVRLRTEGESVVLEVDDGGPGIDAADIPRLFDRFYRADSARGLPGSGLGLSIVQRVVDAHAGRATVARSARGGALLRVVLPAAASPTPIARPTTGEDTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZD4</accession>
    <name>Q9KZD4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6955</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631021.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972191.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6955"/>
    <dbReference type="GeneID" id="1102393"/>
    <dbReference type="KEGG" id="sco:SCO6955"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7055"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_0_0_11"/>
    <dbReference type="OMA" id="AMAYRSH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB89016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="27090" checksum="87F8827C6D2BB5DC" modified="2000-10-01" version="1">MTVSLSLLVAAAVLNAVGATLLLTRSLTRILLGAVVLGNGVNLLVLAATGSAGEAPLLYPHIIRNRVTDPLPQAIALTAIVITLATTAFLLAMAYRSHQVTGSDEISDDTEDRLVALRAEFLDRRGELRDRYREARAGDGGADAEQRARYRAARRRLRRRVREERAYQARANDVSGNLWNDILGADPEDYREGRELGSTDAAGRPAPAPARVAGPSNDPEETGREPDSLPGEDSCHPPPDQPDDPGGAGTEGTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZK8</accession>
    <name>FBIB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional F420 biosynthesis protein FbiB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Coenzyme F420:L-glutamate ligase</fullName>
                <ecNumber evidence="1">6.3.2.31</ecNumber>
                <ecNumber evidence="1">6.3.2.34</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Coenzyme F420-0:L-glutamate ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Dehydro-coenzyme F420-0 reductase</fullName>
                <ecNumber evidence="1">1.3.8.17</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiB</name>
        <name type="ordered locus">SCO3037</name>
        <name type="ORF">SCE34.18</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2</text>
            <dbReference type="Rhea" id="RHEA:60360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="1.3.8.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CofE family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="1"/>
    <dbReference type="EC" id="6.3.2.34" evidence="1"/>
    <dbReference type="EC" id="1.3.8.17" evidence="1"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627259.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028727.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KZK8"/>
    <dbReference type="SMR" id="Q9KZK8"/>
    <dbReference type="STRING" id="100226.SCO3037"/>
    <dbReference type="GeneID" id="1098470"/>
    <dbReference type="KEGG" id="sco:SCO3037"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3097"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051152_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZK8"/>
    <dbReference type="OMA" id="VGSCWIG"/>
    <dbReference type="PhylomeDB" id="Q9KZK8"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052890">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000145784" description="Bifunctional F420 biosynthesis protein FbiB">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme F420:L-glutamate ligase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydro-coenzyme F420-0 reductase" evidence="1">
        <location>
            <begin position="244"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>coenzyme F420-(gamma-Glu)n</name>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01259"/>
        </source>
    </evidence>
    <sequence length="443" mass="46867" checksum="A5D3F5C1E7911BA1" modified="2000-10-01" version="1">MSDETRDAAPGRRDGYRVWALPGLPEVQSGDDLAKLIAAAEPALADGDVLLVTSKIVSKAEGRVVEAADREAAIDAETVRVVARRGPLRIVENRQGLVMAAAGVDASNTPAGTVLLLPEDPDASARGIREGLRDTLGVDVGVIVTDTFGRPWRAGLTDVAIGAAGVRVLDDLRGGTDAYGNPLGATVVATADELAAAGDLVKGKAAGLPVAVLRGLPQVVAEDDGEGARAMVRGARDDMFRLGTSEAVRQAVTQRRTVRAFTDEPVDPGAVRRAVAAAVTAPAPHHTTPWRFVLLESGESRTRLLDAMRDAWIADLRRDGKSEESVAKRVRRGDVLRNAPYLVVPCLVMDGSHTYGDVRRDAAEREMFVVATGAGVQNLLVALAGERLGSAWVSSTMFCRDVVREVLGLPDGWDPMGAVAVGHPAEEPKARPERDAEAFIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN0</accession>
    <name>Q9KZN0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1402</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
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                <person name="Chen C.W."/>
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                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
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                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
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        <location>
            <begin position="889"/>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Cerdeno-Tarraga A.M."/>
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                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
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                <person name="Harper D."/>
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                <person name="Chen C.W."/>
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                <person name="Hidalgo J."/>
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                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
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                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB76988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="27618" checksum="89585AAEFFCE3948" modified="2000-10-01" version="1">MLEPTAAPAAAAEPAAATAPAVAPAADPARILVVDDDPTVAEVVAGYLDRAGYRVDRAGDGPEALARAAGHRPDLVVLDLMLPGMDGLEVCRRLRGQGPVPVIMLTARGDEDDRVLGLEVGADDYVTKPFSPRELVLRVESVLRRTRPAPAPRPPSAAGLTADPAARRATKDGAELALTLREFDLLAFFLRHPGRAFAREELMREVWGWDFGDLSTVTVHVRRLRGKVEDDPARPRLIQTVWGVGYRFDPAGREAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L113</accession>
    <name>Q9L113_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1446</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977379.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096872"/>
    <dbReference type="KEGG" id="sco:SCO1446"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1456"/>
    <dbReference type="HOGENOM" id="CLU_2156964_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="122" mass="12233" checksum="9500B2CFF60A6CAD" modified="2000-10-01" version="1">MDPAAARAVLEVALCVAPAALHEHLLRDFGGAGLALAVMLCAAVATMERRLVLTSPVACPDSSVARLLFHARHLEPLSAGGAAGFMAPLGTAVLLPTVLGWPAADGTAFAEPGSAGTGRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L119</accession>
    <name>Q9L119_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7441</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631490.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031668.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7441"/>
    <dbReference type="GeneID" id="1102879"/>
    <dbReference type="KEGG" id="sco:SCO7441"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7551"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_0_11"/>
    <dbReference type="InParanoid" id="Q9L119"/>
    <dbReference type="OMA" id="AMIQFWR"/>
    <dbReference type="PhylomeDB" id="Q9L119"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="21437" checksum="0FCD79933236522B" modified="2000-10-01" version="1">MMAGKKQFDVDTALDAAMVQYWRAGYADTSLDDLSRATGLNRSSLYSSFGDKESLYLRCLDRYAARYGSRYDHALSRASEEPLRAVRAFFEVTLERIADPDVPDGCLIAQTAMAAPVLGPAIAARAVEALGLQRARLRTALDAARLAEDEADDFAVHMTAVNQSLAVMSRTGASRQQLRTVVDISMSALSRALPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L128</accession>
    <name>Q9L128_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631480.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031659.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102869"/>
    <dbReference type="KEGG" id="sco:SCO7431"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7541"/>
    <dbReference type="eggNOG" id="ENOG503054E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2398436_0_0_11"/>
    <dbReference type="OMA" id="VADIAWT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="86" mass="9435" checksum="F0047767898F0B58" modified="2000-10-01" version="1">MDERKAPVDDGLGDLEPGTRQRTQLRVRVADIAWTAACAVLALWAVWTAIDLARGATAWAYCAVAWLLLAVALTVRVMAVRRRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L176</accession>
    <name>Q9L176_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631451.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031637.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7401"/>
    <dbReference type="GeneID" id="1102839"/>
    <dbReference type="KEGG" id="sco:SCO7401"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7511"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085054_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L176"/>
    <dbReference type="OMA" id="CDVSPKG"/>
    <dbReference type="PhylomeDB" id="Q9L176"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024029">
        <property type="entry name" value="Pyridox_Oxase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04025">
        <property type="entry name" value="PPOX_FMN_DR2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="189" mass="20625" checksum="9A3C843B326A5F4F" modified="2000-10-01" version="1">MPHTTVTTGDRPDAATATEEGWVELDSRAHLRELLGEPWPLVIDKVHDRLTDDDRDILARSPFCLLATSDAGGNCDVSPRGDVPGFTHVLDSRTLALPDRAGNRRGDSFHNVLDNPHAGLLYLIPGGKEVLRVNGRARILTDAPFFDAMARGGRRPDLALLLEIDEIYLHCPMSLNRAGLWNSGSAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L177</accession>
    <name>Q9L177_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC-transport protein, ATP-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7400</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631450.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971743.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7400"/>
    <dbReference type="TCDB" id="3.A.1.14.12">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1102838"/>
    <dbReference type="KEGG" id="sco:SCO7400"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7510"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_11"/>
    <dbReference type="InParanoid" id="Q9L177"/>
    <dbReference type="OMA" id="VEFGRYP"/>
    <dbReference type="PhylomeDB" id="Q9L177"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB76301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="31348" checksum="F6B34DFC4CE925E9" modified="2000-10-01" version="1">MRSGEDAAGTPRLRGHELSATGVTVAYDGVDVVHDAGVRLRPGEVTVLVGPNGSGKSTLLRTVARLQRARSATLSLDGATDGLALTSREFSRYVALLTQGRPTPGGLTVRDVVEFGRYPYRGRWGRPDPDGPAAVERALALTGVDGLADRGADHLSGGQLQRVWLASCLAQETGVLLLDEPTTYLDLRYQVELLDLIRDLADDHGIAVGVVLHDLDQAAAVADRITLLEAGRIVADGPPEDVLTPERLTAVYGIRIDVDTDPLTGRLRTRPIGRHHIRTPRTRTPERLGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1B2</accession>
    <name>Q9L1B2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625846.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977255.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1569"/>
    <dbReference type="GeneID" id="1097000"/>
    <dbReference type="KEGG" id="sco:SCO1569"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1581"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073071_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1B2"/>
    <dbReference type="OMA" id="SKWGYTY"/>
    <dbReference type="PhylomeDB" id="Q9L1B2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="75"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="350" mass="37276" checksum="0A13DCD5B1BBEE94" modified="2000-10-01" version="1">MSGGHRGYVGQQLSSSTAPAVDRTESAMPFARLAAATTPTCHIGLGLAAVGRPGYINLGRDRDLPADRTVEALRERTHDLLDAAYAQGVRYFDAARSYGRSEEFLAGWLRDRPDVDDVVVGSKWGYTYTADWSTEAERHEVKDHGVATYDRQRAETDALLGDRLDLYQIHSLTPDSPALTDKELHARLAEAAAQGSTVGFSTSGPAQADAIRAALAVTVDGEPLFRTVQSTFNALDTSAGPALAEAHQAGLTVIVKEGMANGRLAEPHAPGVLKAVAEETALGCDAVALALVLRQPWAGVVLSGAATVNQLGSNLHAAVVDLDDDQVARLGALAEDPHAYWERRGQLPWH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1I4</accession>
    <name>Y2592_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Exopolysaccharide phosphotransferase SCO2592</fullName>
            <ecNumber>2.7.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Stealth protein SCO2592</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2592</name>
        <name type="ORF">SCC88.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="PLoS Comput. Biol." volume="1" first="492" last="499">
            <title>Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.</title>
            <authorList>
                <person name="Sperisen P."/>
                <person name="Schmid C.D."/>
                <person name="Bucher P."/>
                <person name="Zilian O."/>
            </authorList>
            <dbReference type="PubMed" id="16299590"/>
            <dbReference type="DOI" id="10.1371/journal.pcbi.0010063"/>
        </citation>
        <scope>IDENTIFICATION AS A STEALTH PROTEIN</scope>
        <scope>PREDICTION OF FUNCTION</scope>
    </reference>
    <comment type="miscellaneous">
        <text>Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626829.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028443.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L1I4"/>
    <dbReference type="SMR" id="Q9L1I4"/>
    <dbReference type="STRING" id="100226.SCO2592"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1098026"/>
    <dbReference type="KEGG" id="sco:SCO2592"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2638"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311673_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1I4"/>
    <dbReference type="OMA" id="CTISFWD"/>
    <dbReference type="PhylomeDB" id="Q9L1I4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235959" description="Exopolysaccharide phosphotransferase SCO2592">
        <location>
            <begin position="1"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="942" mass="105064" checksum="108B737B98A97B80" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1V1</accession>
    <name>Q9L1V1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2943</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627167.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028675.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2943"/>
    <dbReference type="CAZy" id="GH20">
        <property type="family name" value="Glycoside Hydrolase Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="1098376"/>
    <dbReference type="KEGG" id="sco:SCO2943"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3001"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_11"/>
    <dbReference type="InParanoid" id="Q9L1V1"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="PhylomeDB" id="Q9L1V1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="141"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB72189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="545" mass="60291" checksum="A61A87FF1447555C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1W7</accession>
    <name>Q9L1W7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6844</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630915.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031229.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6844"/>
    <dbReference type="REBASE" id="17349">
        <property type="entry name" value="M.ScoA3ORF6844P"/>
    </dbReference>
    <dbReference type="GeneID" id="1102283"/>
    <dbReference type="KEGG" id="sco:SCO6844"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6954"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052980_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1W7"/>
    <dbReference type="OMA" id="RANECVW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB71857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="423" mass="46037" checksum="54CAE3EC80751AF9" modified="2000-10-01" version="1">MILDLFAGPGGWSRAVHVLGMRDIGLEWDQWACKTRAAAGQLTIRCDVARYPAWPFIGRTRGVIASPPCQAWSMAGKRLGLVDQPLVHAAVEDLAAGRDTRERLLSACRDERSLLAAEPMRYLYALNTVGEPDWVAMEEVPDVLPLWKQYAAVLRRWGFSVWYGILNAADFGVPQTRKRAILLASRVRTAQPPTPTHAQLAEPESLFGPGRARWVSMAEALGWGATDRPVPTVCAGGGPGGGPEPFPSGSRKTLSDARKRGTWMPRPDRGVLQSCREGTGWAARHRIRESRAADAPAPTFTAEPHRWSWSLRSNNQANATVRSIQEPAGTLFFGHRANECTWVAEPATPPAEEAEVPAVPEPIRITAREAGLLQTFPADYPWAGNKGQQFSQIGNAVPPLLAGHLLAPHLGVALDPDDFTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2C7</accession>
    <name>Q9L2C7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2492</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626734.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028384.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2492"/>
    <dbReference type="GeneID" id="1097926"/>
    <dbReference type="KEGG" id="sco:SCO2492"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2534"/>
    <dbReference type="eggNOG" id="ENOG5033H2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785800_0_0_11"/>
    <dbReference type="OMA" id="KNCTEAY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008613">
        <property type="entry name" value="Excalibur_Ca-bd_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05901">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00894">
        <property type="entry name" value="Excalibur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176838" evidence="6">
        <location>
            <begin position="28"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB69780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="157" mass="15477" checksum="C60E392D8D8F336B" modified="2000-10-01" version="1">MKLLRKPAAVTVAALALAALPAAAAQAHDGAHPFKNCSEAYDAGYSNIKKGDEHYGEHLDRDKDGVGCDKPPAGFVPADGKDSGAKDTDDAADAGSGKDSGSEEGGGAEAAGQQGTDLAETGGDDSTPYLAAGGAVVVLAGGGLLLAARRRRSDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD11</accession>
    <name>Q9RD11_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625199.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027428.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0900"/>
    <dbReference type="GeneID" id="1096323"/>
    <dbReference type="KEGG" id="sco:SCO0900"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.894"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_2_11"/>
    <dbReference type="OMA" id="GWLWAAY"/>
    <dbReference type="PhylomeDB" id="Q9RD11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="427" mass="43719" checksum="C86EDFE5D485089B" modified="2000-05-01" version="1">MSGVTESGVVESDVVGGGSLGRGFGWLWGAYTVSTFGTRLAFDAFPLIAVMVLDAGPARVAALSAAGLAVGAVVAVPLGPWVEFRRKRPVMIATDLLRCAVLLSVPLAYALGRLGFAQLLVVSVVVAAADITFRAAAGSCLKALVRGPDLLRANGRFEATTWTAAMLGPPVGGAAIGLFGPVVTVAADAVSYLLSALGIRAIGGGEPHPRRAAASRLRAGDLLNGWRYVLASPALRPLFLNTVLVNGLIMATAPLLAVLMLGDLGFAPWQYALAFAVPCLGGLVGSRMAGPLVARFGEHRVLVTSGVLRVCWPVGLAFVGPGTGGLVLVMAVEFGLIASVGVYNPVYATRRLELTPADRVARTLSAWTVSGKLTTAALTALWGLLAGLTGTRTAVALAGVLLLATPLLLPRQPHTSAPSPSRPAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDI4</accession>
    <name>Q9RDI4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2743</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626974.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028555.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2743"/>
    <dbReference type="GeneID" id="1098177"/>
    <dbReference type="KEGG" id="sco:SCO2743"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2799"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RDI4"/>
    <dbReference type="OMA" id="CGHCIDM"/>
    <dbReference type="PhylomeDB" id="Q9RDI4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="17340" checksum="DCCE7F655FA0C9E3" modified="2000-05-01" version="1">MDTRFNLFENEFGGRFAKRFAGVGMLVHQSALPQSTQELVSLRASQINGCGHCIDMHVKEAAAAGESAVRLHLVAAWRESTVFTEAERAALALAEEGTRLADAHEGVSDETWELVRKHYDDDQVAALVCLVALINAANRLAVITHQKGGSYEAGMFAAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="152" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ01</accession>
    <name>Q9RJ01_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0164</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36946">
        <property type="entry name" value="T36946"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624500.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026895.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0164"/>
    <dbReference type="TCDB" id="3.A.3.25.1">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1095588"/>
    <dbReference type="KEGG" id="sco:SCO0164"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.137"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_11"/>
    <dbReference type="InParanoid" id="Q9RJ01"/>
    <dbReference type="OMA" id="AQVVIMN"/>
    <dbReference type="PhylomeDB" id="Q9RJ01"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="8">
        <location>
            <begin position="638"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB53131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="776" mass="80626" checksum="3E2C4D66D24ECB7D" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ59</accession>
    <name>Q9RJ59_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1645</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625920.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027898.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1645"/>
    <dbReference type="GeneID" id="1097076"/>
    <dbReference type="KEGG" id="sco:SCO1645"/>
    <dbReference type="eggNOG" id="ENOG503398W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096778_0_0_11"/>
    <dbReference type="OMA" id="CGEIKPH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004211">
        <property type="entry name" value="Endonuclease_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038563">
        <property type="entry name" value="Endonuclease_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02945">
        <property type="entry name" value="Endonuclease_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="21640" checksum="AFFB7A2E19C4A451" modified="2000-05-01" version="1">MAIEEVGRRCSRCKDHKPRAAFARNKAMRDGLQAYCRECAAAYHQERQVAKGCNVRPRVEVPEGHKLCRTCGEIKPHSEWTRNRTASDGLATLCKTCKAAKGRVGHLKRHYGLTEAERDAMVASQMGLCVICLKAPAVHVDHCHKTGKVRGVLCFNCNSAIGKLGDDPDAVRRAAAYLEGTSWKPTLVAPGVYQLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJA1</accession>
    <name>Q9RJA1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-hydroxyacid-family dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0663</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624972.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027278.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0663"/>
    <dbReference type="GeneID" id="1096086"/>
    <dbReference type="KEGG" id="sco:SCO0663"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.647"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_11"/>
    <dbReference type="InParanoid" id="Q9RJA1"/>
    <dbReference type="OMA" id="AMQPERT"/>
    <dbReference type="PhylomeDB" id="Q9RJA1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="46"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="138"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="36929" checksum="2FADF29C2994E5E1" modified="2000-05-01" version="1">MTVHAPGPGHRPRAAVAMSPDAASAVLDPQSLAAFRRVCDLAPFPVLDDLSTARARSVLADVELLVTGWGCPPLDAQVLRSAPRLRAVVHTAGSVRGHVTDACWERGVEVSSAAAANALPVAEYTLGMILLSGKRVLERARDYRASRVRGNWLRTPRGVGNYRRTVGILSASLIGRRVVELLRPHDIEVLLHDPYVTDAEAAELGVENVGLPELFARCDTVSVHTPLLPTTRGLVSRPLIEAMPADAVLINTSRGAVIDQDALTDAALAGRIRAVLDVTDPEALPPEHPLWDCEHALITPHLAGSEGNEWRRLADLALAETTRWASGSGFLHPVRRERLAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB3</accession>
    <name>Q9RJB3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative gas vesicle synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0651</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624960.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027273.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0651"/>
    <dbReference type="GeneID" id="1096074"/>
    <dbReference type="KEGG" id="sco:SCO0651"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.635"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065736_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RJB3"/>
    <dbReference type="OMA" id="CYSFVDP"/>
    <dbReference type="PhylomeDB" id="Q9RJB3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="261" mass="28001" checksum="0D584376DC9E9D0E" modified="2000-05-01" version="1">MTAPATTRAPGSAPEAAPAPQALYVYGITPAGVRTPRSAGVDGAPVRLLTESGLCAAVSAAPPRLRPRRRDLLAHQSVLDELAAQGPVLPMRFAVLSPRTDVLHSQLRSDAAHLTAQLDGVRGCVELNVKGTVVPGHFADLVRRDDKLRTLALRTRRRPDYEANVRLGEAIALGVRREARRAAREVVDRLAPLAVRTVQGATDDEQVLSASFLLRSADEPRFREAVAEQARDRGDRLALSVTGPLPCYSFVDPRPAAPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJC0</accession>
    <name>Q9RJC0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0644</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624953.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027268.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0644"/>
    <dbReference type="GeneID" id="1096067"/>
    <dbReference type="KEGG" id="sco:SCO0644"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.628"/>
    <dbReference type="eggNOG" id="ENOG502Z890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025573_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJC0"/>
    <dbReference type="OMA" id="NGAHHFH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331497" evidence="3">
        <location>
            <begin position="37"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="4">
        <location>
            <begin position="260"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="718" mass="73861" checksum="70C6F22BF2E77DC4" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJC1</accession>
    <name>Q9RJC1_STRCO</name>
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        <submittedName>
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        <name evidence="3" type="ordered locus">SCO0643</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Proc. Natl. Acad. Sci. U.S.A." volume="111" first="8446" last="8451">
            <title>Structural and functional characterization of a conserved pair of bacterial cellulose-oxidizing lytic polysaccharide monooxygenases.</title>
            <authorList>
                <person name="Forsberg Z."/>
                <person name="Mackenzie A.K."/>
                <person name="Sorlie M."/>
                <person name="Rohr A.K."/>
                <person name="Helland R."/>
                <person name="Arvai A.S."/>
                <person name="Vaaje-Kolstad G."/>
                <person name="Eijsink V.G."/>
            </authorList>
            <dbReference type="PubMed" id="24912171"/>
            <dbReference type="DOI" id="10.1073/pnas.1402771111"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.29 ANGSTROMS) OF 43-228 IN COMPLEX WITH COPPER AND ZINC</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624952.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="PDB" id="4OY6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.29 A"/>
        <property type="chains" value="A=43-228"/>
    </dbReference>
    <dbReference type="PDB" id="4OY8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=43-228"/>
    </dbReference>
    <dbReference type="PDBsum" id="4OY6"/>
    <dbReference type="PDBsum" id="4OY8"/>
    <dbReference type="SMR" id="Q9RJC1"/>
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    <dbReference type="CAZy" id="AA10">
        <property type="family name" value="Auxiliary Activities 10"/>
    </dbReference>
    <dbReference type="GeneID" id="1096066"/>
    <dbReference type="KEGG" id="sco:SCO0643"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.627"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="organism ID" value="5998"/>
    </dbReference>
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        <property type="organism ID" value="5998"/>
    </dbReference>
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        <property type="organism ID" value="5998"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176897" evidence="1">
        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="43"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <position position="43"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
            <label>5</label>
        </ligand>
    </feature>
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        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
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        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5 6">
        <location>
            <begin position="112"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="4OY6"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4OY8"/>
        </source>
    </evidence>
    <sequence length="228" mass="25168" checksum="CB5F35C4A3423D65" modified="2000-05-01" version="1">MTCHDRAKIQLAGRARRATTLVLSTLAAVLLTLIPWSGTAVAHGSVVDPASRNYGCWERWGDDFQNPAMADEDPMCWQAWQDDPNAMWNWNGLYRNGSAGDFEAVVPDGQLCSGGRTESGRYNSLDAVGPWQTTDVTDDFTVKLHDQASHGADYFLVYVTKQGFDPATQALTWGELQQVARTGSYGPSQNYEIPVSTSGLTGRHVVYTIWQASHMDQTYFLCSDVDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="122" xmlns="http://uniprot.org/uniprot">
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    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="1095894"/>
    <dbReference type="KEGG" id="sco:SCO0471"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.449"/>
    <dbReference type="eggNOG" id="COG2207">
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    <dbReference type="HOGENOM" id="CLU_066193_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJG3"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="295"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="326" mass="34425" checksum="2FEF5346ACAC80D6" modified="2000-05-01" version="1">MLSTETPTDPSAPAPAVAPTGAPPDWSIVDVAVPRPSVRLAGVAMAGFSQHVSAFVDMAMVAHPSVTLLIDLSDGDGILYSARDRHGHGSFVVGLAPGDLRAAGRVGTCLQIRLEPAVAAAVLGPSAGLGGRVESFEDVWGREAGRVQDELRTAGSWDERFAVAADVLRRRTADRPPVDPEVAHTWRTTLAGRGRVRVEGLAEEVGWSRKRLSARFHAQLGITPKRAARLVRFDHAAHLLAAGLAPASVAFESGYADQSHLHREVKAFTGLTPTAVAGAPWLAIDDVAWPGSSPARSVSAAGSAPRRMARPGRAWNRGRTAWTDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJH1</accession>
    <name>Q9RJH1_STRCO</name>
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        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ordered locus">SCO0463</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0463"/>
    <dbReference type="GeneID" id="1095886"/>
    <dbReference type="KEGG" id="sco:SCO0463"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.441"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RJH1"/>
    <dbReference type="OMA" id="CASPTCQ"/>
    <dbReference type="PhylomeDB" id="Q9RJH1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="22158" checksum="073383DFA385460E" modified="2000-05-01" version="1">MDAVQHQPPRTRVTAQLRALRFDAGTLCLNLVATVGRRPGVPVERMGDAERLEAWCRGVGLTLADGYDPRDVLSSLHALRAAAHDIASGALDAHRPRQESVDLVNLLARPAPPAPRLEVTADGAWVAEGRRALSKEALLSLVARDLIDLMTDEARRSRLAACASEVCRMLCLDSGGGRPRKWCSMRRCGNRAKAAGRRLRESAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJP5</accession>
    <name>Q9RJP5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0595</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624907.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0595"/>
    <dbReference type="GeneID" id="1096018"/>
    <dbReference type="KEGG" id="sco:SCO0595"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.576"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082329_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJP5"/>
    <dbReference type="OMA" id="TYWVGEA"/>
    <dbReference type="PhylomeDB" id="Q9RJP5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="20724" checksum="EE67AC8B21EB7B62" modified="2000-05-01" version="1">MINCTLKPSPQPSNTEALAATVIAALKGHGAEVDVVRAVDLNLKPGVETDMGDGDDWPGVHEKLLASQILVIASPTWLGRPSSVAQRVLERMDAMLGETDDEGRPVAYNRVAGVLVTGNEDGAHHVISEIGGGLADIGYTIPGQAWTYWHLGPGPGPDFLDDERGHDWSVSTGRAMASNLVHAARALDAMPLPAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJS5</accession>
    <name>Q9RJS5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0411</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624732.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027095.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0411"/>
    <dbReference type="GeneID" id="1095834"/>
    <dbReference type="KEGG" id="sco:SCO0411"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.387"/>
    <dbReference type="eggNOG" id="ENOG50303I4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177092_0_0_11"/>
    <dbReference type="OMA" id="TDDEMHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="74" mass="8231" checksum="E0F50328680C1ADA" modified="2000-05-01" version="1">MTFTEEEMEGVRAAAAAEGKSLKQYMHDLGVREMQRKRFVAGAVSWADRLRAEFDEAFPDEIPPSQRGEGVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJY4</accession>
    <name>Q9RJY4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative lacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1186</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625476.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027638.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1186"/>
    <dbReference type="GeneID" id="1096609"/>
    <dbReference type="KEGG" id="sco:SCO1186"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1185"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9RJY4"/>
    <dbReference type="OMA" id="AWRHVIL"/>
    <dbReference type="PhylomeDB" id="Q9RJY4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="341" mass="36747" checksum="DE67EFC19C6100B6" modified="2000-05-01" version="1">MGRQRPGTPTLEEVAARAGVGRGTVSRVVNNAAGVRDSTRRAVQRAIAELGYVPNLAARSLAGHRADAVALVMTEPDWRLFGEPFFTEIVHAVGDALTDTPFQLLLTLVRTDTERRRFVEYARGGRVDGVLLMSVHAEDPLPDMLADAGLPTVMLGRRSGEECVTYVDADNAGGARGAVTYLLDAGRRRIGAISGPLDMYVAQCRLRGYREALEPAGVAAGASLVVEGSDFTEESGHRAMTELLARHPDLDAVFAASDTLAAGALNALRAAGRRVPQDVAVIGFDDFHPARPTDPPLTTVRQPLEEIGRTMVRLLLEEMEDAPVAWRHVILRTELVVRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKN9</accession>
    <name>Q9RKN9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2289</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50598">
        <property type="entry name" value="T50598"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626537.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976524.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2289"/>
    <dbReference type="GeneID" id="1097722"/>
    <dbReference type="KEGG" id="sco:SCO2289"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2326"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_3_0_11"/>
    <dbReference type="OMA" id="TCYDRRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="17710" checksum="57C052F39D4E0BDF" modified="2000-05-01" version="1">MKCCDRRDLGLLLLRLGTGGVLAAHGTQKLLGWFGGGGLGETGRAMEAMGYAPGRASATAAGLAEAGGGTLLALGLATPAAGAAAVGAMAGAAAVHAPNGFFAQAGGYEYAVSLGLTAAGLAVSGPGRLSLDHALGHAVNRNWMVPAAFAVTAAAATAVVGARNRRLRRAAEGRQETLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKT5</accession>
    <name>Q9RKT5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transport system sugar binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6257</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAB60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630357.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030773.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6257"/>
    <dbReference type="GeneID" id="1101698"/>
    <dbReference type="KEGG" id="sco:SCO6257"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6371"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_5_11"/>
    <dbReference type="InParanoid" id="Q9RKT5"/>
    <dbReference type="OMA" id="CVLHEQG"/>
    <dbReference type="PhylomeDB" id="Q9RKT5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176946" evidence="1">
        <location>
            <begin position="32"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="53"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="334" mass="35183" checksum="1603F2BC76171205" modified="2000-05-01" version="1">MARFRTWVGIALAGALSVSLAGCSSTGGKRAEDARKAASAEGRAAVDTPRWTFAMITHSGDGDTFWDIVQSGAEQAAVKDNINFLYSHDAEAQQQAQLVNAAIDKKVDGIIVTLAKPDAMKSALARAHKAGIPVITVNSGSEESKEFGALTHVGQDETIAGEAVGEELNERGREQAVCVLHEQGNVGHEQSCDGVEKTFDGKVQRLYVNGTSMPDVQSAIEAKLQTDKSVDAVVTLGAPYADTAVKAKQGAGSKAEIDTFDLNAKVAAGLADGTLGFAVDQQPYLQGYEAVDLLWLYKYNADVLGGGRPVLTGPQIITKDDAAALADYTKRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKY9</accession>
    <name>Q9RKY9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1431</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625713.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027784.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1431"/>
    <dbReference type="GeneID" id="1096857"/>
    <dbReference type="KEGG" id="sco:SCO1431"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1441"/>
    <dbReference type="eggNOG" id="ENOG502ZP31">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189260_0_0_11"/>
    <dbReference type="OMA" id="EAMTAHS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="80" mass="8301" checksum="207DFFF1190F75D6" modified="2000-05-01" version="1">MTKLSAAKAAHGGKVDTVSGGTPPSRSREQREAMTAHSAAATRVRTGGPKDDDGPKILEHVLGWTLVVVVAMLVVQLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1T7</accession>
    <name>Q9S1T7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0055</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37119">
        <property type="entry name" value="T37119"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624409.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026811.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0055"/>
    <dbReference type="GeneID" id="1095486"/>
    <dbReference type="KEGG" id="sco:SCO0055"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023173_0_0_11"/>
    <dbReference type="OMA" id="WYRQIGH"/>
    <dbReference type="PhylomeDB" id="Q9S1T7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="503" mass="54607" checksum="9304160699316145" modified="2000-05-01" version="1">MLSYDELTSPERELWDAFPEGRRVDLRTGVPDTDAPPAGDRWGPDRTVRAAVVATLLLGANDDRSGTVAALRLTGARITGRLNLSGTEICHTFSLQGCRLDEAVQLHGATTRTIEITNSWVPGINAELARIEGDLDLRRSTFEGGFLILVNARMAGNLLISDARILDPEEWAVRAGGLVLNGGVFGQRLTTQGGLRLPGAQLLSGLFLQGARLGNTAGVALAAGGMAASTVDCSQGFAAQGGVLLRRARIEGLLTFEGAQLNGDGVALDCVSMHVGDFDYRTATPLSGLVDLRSAQATWCQDSEQSWPREVLLEGFTYGSIRFWDAPSAAGDDGPPTRDGVARRLAWLRRNPGYVPQPYEQLAGWYRQIGHDDDARRVLLAKQRHRRLTLSPSARAWGHLLDVTVGYGYRPWLAGVWLLALTLLGTLAFSTHSPSPVKRDEGSPFQPLVYTLDLLIPLGGLGQRTGWYWPNSSLQWLSYLLIAFGWMLTTAIIAGITRTLQKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-10" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S266</accession>
    <name>Y1686_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized Nudix hydrolase SCO1686</fullName>
            <ecNumber>3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1686</name>
        <name type="ORF">SCI30A.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36787">
        <property type="entry name" value="T36787"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625960.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027918.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S266"/>
    <dbReference type="SMR" id="Q9S266"/>
    <dbReference type="STRING" id="100226.SCO1686"/>
    <dbReference type="GeneID" id="1097117"/>
    <dbReference type="KEGG" id="sco:SCO1686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1703"/>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060552_3_1_11"/>
    <dbReference type="InParanoid" id="Q9S266"/>
    <dbReference type="OMA" id="PGYWDVA"/>
    <dbReference type="PhylomeDB" id="Q9S266"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000057087" description="Uncharacterized Nudix hydrolase SCO1686">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="181" mass="19950" checksum="766642DC3C6F8428" modified="2000-05-01" version="1">MDGLMSSADEILDIVDENDRVVGQARRGDAYARGLRHRCVFVWARDPEGRVFVHRRTATKLVFPAPYDMFVGGVVGAGESYDDAALREAEEELGASGLPRPEFLFKFLYDDGAGRTWWSAVYEVRVAGAVSPQVEEVAWHGFLPEAELEGRLGEWEFVPDGLSAYARLRAWRGASGPGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Q5</accession>
    <name>Q9S2Q5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2181</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35297">
        <property type="entry name" value="T35297"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626434.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028184.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2181"/>
    <dbReference type="GeneID" id="1097614"/>
    <dbReference type="KEGG" id="sco:SCO2181"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2219"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_1_11"/>
    <dbReference type="InParanoid" id="Q9S2Q5"/>
    <dbReference type="OMA" id="MKVPSPG"/>
    <dbReference type="PhylomeDB" id="Q9S2Q5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB51265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="590" mass="59036" checksum="A9D58A35A6F0A4ED" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7U0</accession>
    <name>Q9X7U0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7259</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35349">
        <property type="entry name" value="T35349"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631315.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031548.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7259"/>
    <dbReference type="GeneID" id="1102697"/>
    <dbReference type="KEGG" id="sco:SCO7259"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7361"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049717_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X7U0"/>
    <dbReference type="OMA" id="VYHCVNV"/>
    <dbReference type="PhylomeDB" id="Q9X7U0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="34324" checksum="880A5038EF931625" modified="1999-11-01" version="1">MSAATPQPPAPHVVLGSGPAGTALARELVRRGHPVRLVDRRATGPAVEGVERFPADVGTADGARAAIRDAAVVYHCVNVAYHLQVEVMPRVQEAVLAAVEESGARLVVLDTVYPYGETGGAVMTEDSPWKATSRKGRMRAELDERYLAAHRSGRARVVLGRSADFVGPGVLNSSLGAAVFPGALTGGDVVAMGNIDLPHSYTGIEDVAAALATLGERPDGDGRVWHLPTAPAVSTREIHALIEKRVGRPLNVVVLERPRPFGPFDEQLMAEYEEMFYQHTEAQIMDSGAFERFFEAAPTPLADTLDATVTWYEAWLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA21</accession>
    <name>Q9XA21_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3843</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36712">
        <property type="entry name" value="T36712"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628031.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975091.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3843"/>
    <dbReference type="GeneID" id="1099279"/>
    <dbReference type="KEGG" id="sco:SCO3843"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3913"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047963_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA21"/>
    <dbReference type="OMA" id="FKSEVQP"/>
    <dbReference type="PhylomeDB" id="Q9XA21"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="217"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="30824" checksum="341B044E8E031B27" modified="1999-11-01" version="1">MGVLKKFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNATIWNRDRTVVPNDFIVELSTPDFERLSPYSGQLGDELAGMVRDYAKQQRYTFMGPIKVHLEKADDLDTGLYRVRSRTLASSTSHQGGPAAAAPPAPPARPAGPGGGYGYPPAAAPAGAPPMPSAPPPGGRPGGYGYPQPAGGQQPPAAPAPGGRTRHWIEINGTRHQISRATLVMGRSTEADVRIDDPGVSRRHCEIRTGTPSTIQDLGSTNGIVVDGQHTTRATLRDGSRIVVGSTTVIYRQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA22</accession>
    <name>Q9XA22_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO3842</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36711">
        <property type="entry name" value="T36711"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628030.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029265.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3842"/>
    <dbReference type="CAZy" id="CBM12">
        <property type="family name" value="Carbohydrate-Binding Module Family 12"/>
    </dbReference>
    <dbReference type="GeneID" id="1099278"/>
    <dbReference type="KEGG" id="sco:SCO3842"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3912"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_5_1_11"/>
    <dbReference type="InParanoid" id="Q9XA22"/>
    <dbReference type="OMA" id="YFPNEPR"/>
    <dbReference type="PhylomeDB" id="Q9XA22"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="6">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB45209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="30904" checksum="2051A564DA20A2E4" modified="1999-11-01" version="1">MTSDTPTTPDEPGPRPGPGSGADRGISRKTLLRAAVAAGAAVPLLATGGVALARDAARSGDGQRLTPTPYCDDGDDLTPDQMEGPYFKPNSPLRTNLVTPGTPGTPLTVSGYVFGRNCVPLSGVLLDFWQADDNGDYDMAGYTFRGHQFTGATGAFALKTIVPGLYPGRTRHIHVKVQAPGEPVLTTQLYFPGEPRNSTDMIFDPALLMNVRGAGGGKEGTFDFVLNVDGDTGPTDPPTDPPTDPPGGTWASGHAYTSGDRVTYGGRSYRCLQAHTAMTGWEPPNVPALWQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA27</accession>
    <name>Q9XA27_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3837</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36706">
        <property type="entry name" value="T36706"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628025.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029262.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3837"/>
    <dbReference type="TCDB" id="9.A.31.1.2">
        <property type="family name" value="the putative sdpab peptide antibiotic-like killing factor exporter (sdpab) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1099273"/>
    <dbReference type="KEGG" id="sco:SCO3837"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3906"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045120_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XA27"/>
    <dbReference type="OMA" id="GSRWQDG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="HTTM" evidence="7">
        <location>
            <begin position="17"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB45204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="436" mass="46795" checksum="7218EE34C0CD98BB" modified="1999-11-01" version="1">MNAAVLSVSRGIARVTGAALGQYQTAVIRIGFSATWLLFLLRELPHRNELYGPDGPWSHDLAEQLLSDNGAFTALMWSDGRAWFEIVYAVAVLSSVLLLLGWRTRTMSVLFMIGVLSLQNRSVFMGDGGDNVVHLMSIYLVLTRCGRVWSLDARRARRAAAARARGERVEDRVGPVLWCALGFLLLTVTLAGGLDGDWFVPALLWAVWIALGLWWAVGRGGEGSQPRILLDVVTSIVHNGALVVIMAEACLIYATAGWYKIQGSRWQDGTAVYYPLHLDYFSPWPALSDALAASGTMVMLITYGTVAVQVAFPFTLFNRRVKNVLLAAMMIEHAVIAVTLGLPFFSLAMIAADAVFLPTSFLRRLGGWAARARGRLFGRGPSGGLAKAPDGGGRGDGSGRTATVPGPRAREAGGPVAGTGAVDGKDADPTHVGFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAE4</accession>
    <name>Q9XAE4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35634">
        <property type="entry name" value="T35634"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629439.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030159.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5295"/>
    <dbReference type="GeneID" id="1100736"/>
    <dbReference type="KEGG" id="sco:SCO5295"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5381"/>
    <dbReference type="eggNOG" id="ENOG503406I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168330_0_0_11"/>
    <dbReference type="OMA" id="PPKWYEV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="107" mass="11568" checksum="29F29CF939C03A89" modified="1999-11-01" version="1">MKSEDTPFEGGPMDGRVLPVLVGMTGHPPKTYRIPVPDPDGGPPTVLVYRRVPRDSRGGLRFARWKYAYAPEGAKGSGRKWPWSKPERPSAAEPDATPGGKPDDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAH1</accession>
    <name>Q9XAH1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5331</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35599">
        <property type="entry name" value="T35599"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629472.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030180.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5331"/>
    <dbReference type="REBASE" id="22996">
        <property type="entry name" value="ScoA3ORF5331P"/>
    </dbReference>
    <dbReference type="GeneID" id="1100771"/>
    <dbReference type="KEGG" id="sco:SCO5331"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5416"/>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_269467_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAH1"/>
    <dbReference type="OMA" id="ACFWLKQ"/>
    <dbReference type="PhylomeDB" id="Q9XAH1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1200" mass="135817" checksum="E272928D64E5F7E4" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5A1</accession>
    <name>Q9Z5A1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glyoxylate carboligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6201</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34855">
        <property type="entry name" value="T34855"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030737.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6201"/>
    <dbReference type="GeneID" id="1101642"/>
    <dbReference type="KEGG" id="sco:SCO6201"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6314"/>
    <dbReference type="eggNOG" id="COG3960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_3_11"/>
    <dbReference type="InParanoid" id="Q9Z5A1"/>
    <dbReference type="OMA" id="TLMGWGA"/>
    <dbReference type="PhylomeDB" id="Q9Z5A1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01504">
        <property type="entry name" value="glyox_carbo_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="193"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="393"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="594" mass="63836" checksum="B10E33B1539617BC" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBK7</accession>
    <name>Q9ZBK7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO6467</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35954">
        <property type="entry name" value="T35954"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630550.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972511.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6467"/>
    <dbReference type="GeneID" id="1101906"/>
    <dbReference type="KEGG" id="sco:SCO6467"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6567"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071052_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBK7"/>
    <dbReference type="OMA" id="ESGMARH"/>
    <dbReference type="PhylomeDB" id="Q9ZBK7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA22715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="27738" checksum="2D1587B365A99008" modified="1999-05-01" version="1">MPLSLRLSIADTLTLGNATCGFMAVYFTTTGILIPHLMGSDESGMARHSAATAVILMLCAAIFDLFDGLVARKLRSSPMGAELDNLSDLISFGLAPAYFVLVYGMVADDAYQRVAAVGAIVVLLAVVLRLARFSCVTVKDGTFQGMPSPFGALTVVSIVLLELPFVATLLAILGTAWLMVSRVEYPKPRGRLAVAMLSWIVLSMGLLAGWAFDAPSGQLLLQTGCALQLVMGAVIPLFATARRVNNFRDNRREARAAQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBQ0</accession>
    <name>Q9ZBQ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5579</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35663">
        <property type="entry name" value="T35663"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629714.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973415.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5579"/>
    <dbReference type="TCDB" id="2.A.39.1.6">
        <property type="family name" value="the nucleobase:cation symporter-1 (ncs1) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101020"/>
    <dbReference type="KEGG" id="sco:SCO5579"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5669"/>
    <dbReference type="eggNOG" id="COG1457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_3_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBQ0"/>
    <dbReference type="OMA" id="MYSAGFT"/>
    <dbReference type="PhylomeDB" id="Q9ZBQ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA22422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="485" mass="50784" checksum="6196923A6E2DFF39" modified="1999-05-01" version="1">MSKTAENEGALETRGIEQVPDHERTARTRELFPTWVGANISVLLLTMGASLVVAYRLNFWQALVVAGAAPVVSYGLVGLIGIAGKRGGAPGMALSRAVFGQRGNLLPGSLIWVARWGWETINAVTGAYALLTVLDIVFGIRANSVLDMVTLLAFVVATFAISGLGINAVQKCNKYAAYLFGAFSVLVLGYLVVDTDWSAVFDRSAGSVAAMITGVGLIAAGGVSWIPSAPDFTRYLPRTASSKGIVGVTVGGAGIVVLPMVLMGAVMAVSTPDLASAADPVSFLGEILPTWIAVPYLLIALIGMLLINSMSMYSAGFTAQTLGFKVPRHWAVSVNAVISLVFGGVLMLVATSFMGSFIAFLSLLAVAFSAWVGVFGADMLRGREYDGEALADTGRTSAYWYRGGFSPAAVVAWAVGLAAGLMFTTSDWFTGPLATDNFVGEYGLGWVATVVISALLYAVLPKPALIVPDARAERAEQPEAETVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O50520</accession>
    <name>O50520_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5846</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35882">
        <property type="entry name" value="T35882"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629969.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030494.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5846"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="GeneID" id="1101288"/>
    <dbReference type="KEGG" id="sco:SCO5846"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5944"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404246_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174830" evidence="1">
        <location>
            <begin position="35"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA15803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="689" mass="76056" checksum="E83E7BB62018CD6A" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O69972</accession>
    <name>O69972_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="7" type="ordered locus">SCO5796</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35116">
        <property type="entry name" value="T35116"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629920.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030461.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="SMR" id="O69972"/>
    <dbReference type="STRING" id="100226.SCO5796"/>
    <dbReference type="GeneID" id="1101238"/>
    <dbReference type="KEGG" id="sco:SCO5796"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5887"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_7_0_11"/>
    <dbReference type="InParanoid" id="O69972"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="PhylomeDB" id="O69972"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="6">
        <location>
            <begin position="275"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA18333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="497" mass="54507" checksum="FB3646D4D6E54028" modified="1998-08-01" version="1">MTSSSSPSQDTKRLAQTYPEGLRADALMEEDVAWNRGNDSQWDGEQFDRSDRAALRRVAGLSTELEDVTEVEYRQLRLERVVLVGVWTSGTVQDAENSLAELAALAETAGALVLDGVVQRRDKPDAATYIGSGKAEELRDVVLHTGADTVICDGELSPGQLIHLEDVVKVKVIDRTALILDIFAQHAKSREGKAQVALAQMQYMLPRLRGWGQSLSRQMGGGKGGGLATRGPGETKIETDRRRIREKMAKMRREIAEMKTGREIKRQERKRHKVPSVAIAGYTNAGKSSLLNRLTGAGVLVENALFATLDPTVRRAETPSGRLYTLADTVGFVRHLPHHLVEAFRSTMEEVGDSDLILHVVDGSHPVPEEQLAAVREVIRDVGATDVPEIVVINKADMADPLVLQRLLRIEKRAIAVSARTGQNIDQLLALIDNELPRPSVEIEALVPYTHGKLVARAHDEGEVISEEHTPEGTLLKVRVHEELAAELAPYVPAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O86519</accession>
    <name>O86519_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5537</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29067">
        <property type="entry name" value="T29067"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629671.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973459.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5537"/>
    <dbReference type="DNASU" id="1100977"/>
    <dbReference type="GeneID" id="1100977"/>
    <dbReference type="KEGG" id="sco:SCO5537"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5624"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_1_0_11"/>
    <dbReference type="InParanoid" id="O86519"/>
    <dbReference type="OMA" id="DRFDFMW"/>
    <dbReference type="PhylomeDB" id="O86519"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="18921" checksum="0A5ED85A2F2A873D" modified="1998-11-01" version="1">MVAGGFGVGKTTFVGAVSEINPLRTEAVMTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGAIGAIVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGQQPYNPDEVREALQIGPDTPIITTDARHRADAKSALITLVEHALMARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O86552</accession>
    <name>O86552_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6618</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29124">
        <property type="entry name" value="T29124"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630695.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031046.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6618"/>
    <dbReference type="GeneID" id="1102057"/>
    <dbReference type="KEGG" id="sco:SCO6618"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6725"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184535_0_0_11"/>
    <dbReference type="OMA" id="ALACEGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="23700" checksum="D25E95F6E10423B5" modified="1998-11-01" version="1">MNGGRAMKWFQRDREERPAGVVPLSGVVKSESAPGQAPPPLGAGGPVLQRIGGHSDQVARMTTPAEPVILDITHQGRGHFVVDALDAGLHSQSQLVYTDGPFACRALVNADDRTVRALRVQADGPWAIEATAVSSAAALDGAARCPASNVLRYEGGPGIASLCHEGDPRAEDGGYFLVDTYAPDGNGFLDELANHVGPWRGEAPLTGPCLIYARSDGPWSISVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O86710</accession>
    <name>O86710_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6528</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35220">
        <property type="entry name" value="T35220"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630609.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030990.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6528"/>
    <dbReference type="GeneID" id="1101967"/>
    <dbReference type="KEGG" id="sco:SCO6528"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6631"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_1_0_11"/>
    <dbReference type="InParanoid" id="O86710"/>
    <dbReference type="OMA" id="YDGWILI"/>
    <dbReference type="PhylomeDB" id="O86710"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA20625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="474" mass="48745" checksum="1208E710BAF42836" modified="1998-11-01" version="1">MHVTGTVPPPAPEPRETPAAPDHTTLADPAPGNGRHARRFGLPVATALVMGNIIGGGIFLLPASVAPFGTISLLAFGVLTVGAIALALVFGRLAARDPHTGGPYVYARGAFGDFAGFLAAWAYWITTWVSNAALAVAAVGYLDVLIPVNDHRWTACLAALVVQWLPALANFAGTRWVGAVQLVSTVLKFAPLLLVAVGGLFFFDADNLGPFNASGSGGIGAVSAAAAILLFSYLGVESAAVSAGEVEDPRRTVGRATVIGTAGAALVYLLGTLSVFGTVAHDRLVTSDAPFSDAVNAMFGGAWGGWAVALAALVSMTGCLNGWTLLSAQTPYAAARDGLFPAAFARKRRGVPTTGVGVTVVLASLLTVYNYTSGSAKVFEVLVLVTTFTATVPYLLATAAQIFHLVSGQGERVDRARLVRDGIAASVAAAFSLWLVAGAGYAAVYQGVLFLFAGVLVYAVMAARRRRAETSNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>O86725</accession>
    <name>O86725_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6543</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35235">
        <property type="entry name" value="T35235"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630624.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972436.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101982"/>
    <dbReference type="KEGG" id="sco:SCO6543"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6647"/>
    <dbReference type="eggNOG" id="ENOG5031WM4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2572256_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="9005" checksum="560F2293655B6F1D" modified="1998-11-01" version="1">MARTWEGPAGRLLLGLAVLLHRTVTDRAAKRRLEHWRNAALRAAYRRGVPVGVLASRTRLTQRWVRTVVTGGKPPPVDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O86755</accession>
    <name>O86755_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5644</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35454">
        <property type="entry name" value="T35454"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629774.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030359.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5644"/>
    <dbReference type="GeneID" id="1101083"/>
    <dbReference type="KEGG" id="sco:SCO5644"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5727"/>
    <dbReference type="eggNOG" id="ENOG5033D1C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320269_0_0_11"/>
    <dbReference type="OMA" id="YAVINEH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="208" mass="23346" checksum="073C1CF9A016352D" modified="1998-11-01" version="1">MSVLGSNCGEPSDWAVKRFGRHAGRLVETIPEQLGRAHARAHAVHLTARLKRRSPYGSTLAEAVRENLADTARELGGAVRDLRGYEYAVISDHALFPFKYANRLKPLERARLAADASPTRRRMLLSHGPEPEDGLFPLDDEYTTEEYEGLRETFEALGASTKLVCLFFTADPEGGIHVIHWGDARLEPDRTFTWLYSEQLRVATQSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O86782</accession>
    <name>O86782_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4741</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35570">
        <property type="entry name" value="T35570"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628899.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029832.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4741"/>
    <dbReference type="GeneID" id="1100182"/>
    <dbReference type="KEGG" id="sco:SCO4741"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4813"/>
    <dbReference type="eggNOG" id="COG4405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102450_3_1_11"/>
    <dbReference type="OMA" id="RAGHERF"/>
    <dbReference type="PhylomeDB" id="O86782"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06553">
        <property type="entry name" value="ASCH_Ef3133_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009326">
        <property type="entry name" value="DUF984"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39203">
        <property type="entry name" value="PTHR39203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="19782" checksum="64AE8302ABBDB10D" modified="1998-11-01" version="1">MALEPDPPPPSPHPPSPPPPSPHPSSPPSSSSPSSSPSPPVPAPPVPGLGSLPRAEFGFPGPLRDRLVAAVLDGSKTSTTGLVADYEHEGEPLPEAGRREVVVDSRERPVAVIEVTEVRVVPLAEVDLAHAVDEGEGDTSVAGWRAGHERFWHGAEMRAALGDPGFTVDDATPVVLERFRIVTLLPAPGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-05-25" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>P16246</accession>
    <name>HIS8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Histidinol-phosphate aminotransferase</fullName>
            <ecNumber>2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hisC</name>
        <name type="ordered locus">SCO2053</name>
        <name type="ORF">SC4G6.22c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Gene" volume="90" first="31" last="41">
            <title>Cloning and characterization of the histidine biosynthetic gene cluster of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Limauro D."/>
                <person name="Avitabile A."/>
                <person name="Cappellano M."/>
                <person name="Puglia A.M."/>
                <person name="Bruni C.B."/>
            </authorList>
            <dbReference type="PubMed" id="2199329"/>
            <dbReference type="DOI" id="10.1016/0378-1119(90)90436-U"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9"/>
    <dbReference type="EMBL" id="M31628">
        <property type="protein sequence ID" value="AAA26756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JQ0637">
        <property type="entry name" value="JQ0637"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626313.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976762.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P16246"/>
    <dbReference type="SMR" id="P16246"/>
    <dbReference type="STRING" id="100226.SCO2053"/>
    <dbReference type="PRIDE" id="P16246"/>
    <dbReference type="GeneID" id="1097487"/>
    <dbReference type="KEGG" id="sco:SCO2053"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2085"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_11"/>
    <dbReference type="InParanoid" id="P16246"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="PhylomeDB" id="P16246"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000153463" description="Histidinol-phosphate aminotransferase">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="369" mass="40388" checksum="AA572A9BB0C93E08" modified="1990-08-01" version="1">MTFGIDDLPVRDELRGKSPYGAPQLDVPVRLNTNENPYPLPEALVERIAERVREAARDLNRYPDRDAVELRTQLARYLTDTSGHPLDVSNVWAANGSNEVIQQLLQTFGGPGRTAIGFEPSYSMHGLIARGTGTGWISGPRHEDFTIDVPAATRAIDEHRPDVVFITTPNNPTGTAVPAETVLALYEAAQAAKPSMVVVDEAYIEFSHGASLLPLLDGRPNLVVSRTMSKAFGAAGLRLGYLAAHPAVVDAVQLVRLPYHLSAVTQATALAALEHTDTLLKYVEQLKTERDRLVAELRAIGYAVTESDANFVQFGRFADSHATWRKILDRGVLVRDNGVPGWLRVTAGTPEENDAFLDAVREVKKEQHT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>P33158</accession>
    <name>GPMA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-dependent PGAM</shortName>
            <shortName evidence="1">PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">dPGM</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name type="synonym">gpm</name>
        <name type="synonym">pgm</name>
        <name type="ordered locus">SCO4209</name>
        <name type="ORF">2SCD46.23</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="J. Bacteriol." volume="174" first="434" last="440">
            <title>Phosphoglycerate mutase from Streptomyces coelicolor A3(2): purification and characterization of the enzyme and cloning and sequence analysis of the gene.</title>
            <authorList>
                <person name="White P.J."/>
                <person name="Nairn J."/>
                <person name="Price N.C."/>
                <person name="Nimmo H.G."/>
                <person name="Coggins J.R."/>
                <person name="Hunter I.S."/>
            </authorList>
            <dbReference type="PubMed" id="1530847"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 2-26</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text>Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="M83661">
        <property type="protein sequence ID" value="AAA26800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S30886">
        <property type="entry name" value="S30886"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628384.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974762.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P33158"/>
    <dbReference type="SMR" id="P33158"/>
    <dbReference type="STRING" id="100226.SCO4209"/>
    <dbReference type="PRIDE" id="P33158"/>
    <dbReference type="GeneID" id="1099649"/>
    <dbReference type="KEGG" id="sco:SCO4209"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4273"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_11"/>
    <dbReference type="InParanoid" id="P33158"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="PhylomeDB" id="P33158"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000179923" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1530847"/>
        </source>
    </evidence>
    <sequence length="253" mass="28279" checksum="6850B3CCCA93164A" modified="2007-01-23" version="3">MADAPYKLILLRHGESEWNEKNLFTGWVDVNLTPKGEKEATRGGELLKDAGLLPDVVHTSVQKRAIRTAQLALEAADRHWIPVHRHWRLNERHYGALQGKDKAQTLAEFGEEQFMLWRRSYDTPPPALDRDAEYSQFSDPRYAMLPPELRPQTECLKDVVGRMLPYWFDAIVPDLLTGRTVLVAAHGNSLRALVKHLDGISDADIAGLNIPTGIPLSYELNAEFKPLNPGGTYLDPDAAAAAIEAVKNQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q7APH3</accession>
    <name>Q7APH3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acid-dependent transcriptional regulator (TetR-family), MmyR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mmyR</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639856.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039548.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095329"/>
    <dbReference type="KEGG" id="sco:SCP1.246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8192"/>
    <dbReference type="HOGENOM" id="CLU_069356_8_1_11"/>
    <dbReference type="InParanoid" id="Q7APH3"/>
    <dbReference type="OMA" id="HWDASIS"/>
    <dbReference type="PhylomeDB" id="Q7APH3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="21883" checksum="0DA3465E7DEFB448" modified="2012-05-16" version="1">MKQARAMRTRDQVLDAAAEEFALHGYAGTNLATVAVRTGMTKGALYGHFPSKKALADELVSQSTETWNTIGRSIAETACAPETALRALVLAVSRQMKHDIRFRAALRLAADCTMPAGGAPDLLDRIRREMAAAARDTQQQQAPYSPLATQPPDVVVHLLLTVAYGLSFAAERGAPGRSPATTDKVWELLLTALQLEDISTCHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJP3</accession>
    <name>Q8CJP3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptide ABC transporter integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6113</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAD55370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972807.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6113"/>
    <dbReference type="GeneID" id="1101554"/>
    <dbReference type="KEGG" id="sco:SCO6113"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6216"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_11"/>
    <dbReference type="InParanoid" id="Q8CJP3"/>
    <dbReference type="OMA" id="IFYATPS"/>
    <dbReference type="PhylomeDB" id="Q8CJP3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAD55370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="319" mass="34534" checksum="186641A48392B409" modified="2003-03-01" version="1">MSTYSFLIRRVLQALAVVLLVTVVVFCLLHALPGGPARGILGPQATASQIAAFNHEQGLDKPLPVQYVYYLNQLIHGDLGMSYTLNEPVSQLITERLPKTLLLTVLSAVVGLLVAVPLGVWQAVRRNKPVDYVITTLSFIAYSTPVYFLGLILVLVFSQVLPWFPAQAPQGNSVADVLSQPQGLVLPVVAGAATMVAVFSRYMRSATLENLTEDYVRTARAGGTRPRAILTRHVFRNSLTPVVAMLGYYIPVLFGGALVVEQLFNYPGMGLLFWTAAQSSDYPVLLGCVLVISVATVTGTLLADVLQRVIDPRVKAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJT9</accession>
    <name>Q8CJT9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4369</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAD55481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733635.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029610.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4369"/>
    <dbReference type="GeneID" id="1099809"/>
    <dbReference type="KEGG" id="sco:SCO4369"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4437"/>
    <dbReference type="eggNOG" id="COG5555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016303_1_0_11"/>
    <dbReference type="InParanoid" id="Q8CJT9"/>
    <dbReference type="OMA" id="HEARFWK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="540" mass="54031" checksum="DD118ABD802A3205" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK66</accession>
    <name>Q8CK66_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAD55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37020">
        <property type="entry name" value="T37020"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733493.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026913.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0189"/>
    <dbReference type="DNASU" id="1095613"/>
    <dbReference type="GeneID" id="1095613"/>
    <dbReference type="KEGG" id="sco:SCO0189"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.162"/>
    <dbReference type="eggNOG" id="COG3349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026366_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CK66"/>
    <dbReference type="OMA" id="HGFHGFF"/>
    <dbReference type="PhylomeDB" id="Q8CK66"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="522" mass="56708" checksum="A11ACC1776ACBACF" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IY5</accession>
    <name>Q93IY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative gntR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5100</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629250.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973878.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5100"/>
    <dbReference type="GeneID" id="1100541"/>
    <dbReference type="KEGG" id="sco:SCO5100"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5181"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_1_11"/>
    <dbReference type="OMA" id="PFRQEQA"/>
    <dbReference type="PhylomeDB" id="Q93IY5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="27022" checksum="CA3F803F64F5CCD6" modified="2001-12-01" version="1">MTFGEQPAYLRVAGDLRKKIADGLLPPHTRLPSQARIREEYGVSDTVALEARKVLMAEGLVEGRSGSGTYVRERPVPRRVARSGYRPAGGATPFRQEQADGDARGTWESRSEQAEASGAVAERLGIKPGDRVMCTRYVFREAGEAVMLSTSWEPLDLTGRTPVMLPEEGPLGGMGVVERMAAIDVVVDNVTEEVGARPGLAEELLALGGVPGHVVLVVQRTFYASGRAVETADVVVPADRYRVAYHLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RV8</accession>
    <name>Q93RV8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotran_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626135.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028020.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1868"/>
    <dbReference type="GeneID" id="1097302"/>
    <dbReference type="KEGG" id="sco:SCO1868"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1893"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_11"/>
    <dbReference type="InParanoid" id="Q93RV8"/>
    <dbReference type="OMA" id="PWDSCYG"/>
    <dbReference type="PhylomeDB" id="Q93RV8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC38803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="37632" checksum="F7F491FCD29B87F9" modified="2001-12-01" version="1">MDGEVTGPHSGAMESFENLVRTEFAPKTTYLNTASTGLLPARTLAAMRDAAASAAEGQPLDMFADVEASRAAYARLVGVPATRVATGASVATFSGLVAASLPPGAEVLTAEADFSSLVNPLYTRGDLKVRSVPLERLAESVGPDTALVAVSSVQSADGRLADLAALRDAARAHGARTLIDASQSNGWLPLAAGDFDFVVAVAYKWVLCPRGVAFLVVPEDLGAAAGLTPLFAGWASGEHPWDSCYGPVEELAHSARRFDESPALFSYTGARHSLALIEELGVDAVHAHDTGLADRFRAGVRSLGHEPVDAPGSAIVSVPGLGHRQGELGGAGVQVSDRAGNLRAAFHAYNTAADVDRLLDVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK87</accession>
    <name>Q9AK87_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1375</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625659.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977451.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1375"/>
    <dbReference type="GeneID" id="1096798"/>
    <dbReference type="KEGG" id="sco:SCO1375"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1383"/>
    <dbReference type="eggNOG" id="ENOG50330PX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191540_0_0_11"/>
    <dbReference type="OMA" id="CQHQPSC"/>
    <dbReference type="PhylomeDB" id="Q9AK87"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="67" mass="7068" checksum="CC92C1789C9EBDC6" modified="2001-06-01" version="1">MCQHQPPCPSAVSADRESARLVAHHPEQGWSLLCNGVVLFEDTGELLPDGRVIAPHRPVGAGLTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWQ0</accession>
    <name>Q9EWQ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7677</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031822.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7677"/>
    <dbReference type="GeneID" id="1103115"/>
    <dbReference type="KEGG" id="sco:SCO7677"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7796"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_4_11"/>
    <dbReference type="InParanoid" id="Q9EWQ0"/>
    <dbReference type="OMA" id="AENHHVC"/>
    <dbReference type="PhylomeDB" id="Q9EWQ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176639" evidence="2">
        <location>
            <begin position="30"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="108"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC17494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="528" mass="55917" checksum="BE0E9E870C3E68B5" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F370</accession>
    <name>Q9F370_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4418</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628586.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974564.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9F370"/>
    <dbReference type="STRING" id="100226.SCO4418"/>
    <dbReference type="GeneID" id="1099858"/>
    <dbReference type="KEGG" id="sco:SCO4418"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4488"/>
    <dbReference type="eggNOG" id="COG0259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_3_11"/>
    <dbReference type="InParanoid" id="Q9F370"/>
    <dbReference type="OMA" id="FYWPVLG"/>
    <dbReference type="PhylomeDB" id="Q9F370"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="6">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="7">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC08427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24633" checksum="2534674B8FC2FB34" modified="2001-03-01" version="1">METDLHELLRSLRVWDPAVTELPPLDPAGAPGDPLELFTRWFAEAVAAGEREPHTVSLATADAEGLPDARIVMLHGADADGWAFATHADSRKGRHLAARPYAALVFYWPVLGRQVRLRGPVAVAPADQARADLHARSTGALAAALTGRQSAELDSPEELARASQAAWERAEREPDAPVASWTLYRLRPAEVEFFQGEARRRHVRLAYRRTAEEGWDRRLLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F375</accession>
    <name>Q9F375_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative araC family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4413</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628581.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974569.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4413"/>
    <dbReference type="GeneID" id="1099853"/>
    <dbReference type="KEGG" id="sco:SCO4413"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4482"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="InParanoid" id="Q9F375"/>
    <dbReference type="OMA" id="HWASAEH"/>
    <dbReference type="PhylomeDB" id="Q9F375"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="235"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="344" mass="37003" checksum="52CBC1714A0F12DD" modified="2001-03-01" version="1">MAPETLSAPGAHGAPVRPHRVVVLALDGLLPFELGIASRIFGLARDEHRRPLYEVVTCSVRPPGPVATDADFEILVGNGPEALATADTVVVPASYELGPVYEEGVLTGELSAALAHVRPGTRLVAICTGGFVLAAAGYLDGRPATTHWASAEHFQRVFPKVRVDADVLFVDDGDVLTSAGVAAGIDLCVHIVRRDHGTAVANEVARRTVVPPHRDGGQAQYIERPVPDPQQSSTTAARVWALGRLHEPIQLRDMAAQESMSVRTFTRRFREEVGVSPGQWLTRQRVERARHLLESTALSVDQVAQDAGFGTAQSMRQHLQAVLGVTPTGYRRTFRAELSTACGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F384</accession>
    <name>Q9F384_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4404</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628572.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974578.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4404"/>
    <dbReference type="GeneID" id="1099844"/>
    <dbReference type="KEGG" id="sco:SCO4404"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4472"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_0_11"/>
    <dbReference type="InParanoid" id="Q9F384"/>
    <dbReference type="OMA" id="YIFGDTM"/>
    <dbReference type="PhylomeDB" id="Q9F384"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAC08413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="27770" checksum="DDE0602083C6820A" modified="2001-03-01" version="1">MSNLSLAVRDSSTMLRRNLLHARRYPSLTLNLLLTPVMLLLLFVYVFGDAMSAGIGGGGDRSDYVSYLVPGLLLMTIGSTTIGTAVSVSNDMTEGIIARFRTMAIHRGSVLVGHVIGSVVQSIMSVVLVGAVGVAIGFRSTDATALEWLAAFGLLLLFTLALTWIAVGMGLISPNAEAASNNALPLIFLPLISSAFVPIDSMPGWFQPIAEYQPFTPAIETLRGLLLGTGIGHNGWLALGWCLALTALGYVWATSKFNSDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F389</accession>
    <name>Q9F389_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7586</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631629.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971557.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7586"/>
    <dbReference type="GeneID" id="1103024"/>
    <dbReference type="KEGG" id="sco:SCO7586"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7701"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_1_11"/>
    <dbReference type="InParanoid" id="Q9F389"/>
    <dbReference type="OMA" id="YQDTPGL"/>
    <dbReference type="PhylomeDB" id="Q9F389"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="357" mass="38058" checksum="C6A3A0EA7F7054EF" modified="2001-03-01" version="1">MTSLFDSYRLGELTLPNRMVMAPMSRVRAAGGGLATPSMATYYAQRATAGLIVSEGVQPNEVGQSNPGTPGLHTDEQVAAWRPVTAAVHTNGGRIFAQIMHGGRVSHPDTTGMLPVGPSAVPAVGEVFTPTGPQPVPTPRALETAEVPEQARSYAEAARRAVDAGFDGVELHGANGYLISQFLSTNANLRTDRYGGPVAHRIRFAVEAVSATVEAVGADRTGIRLSPAGTFWGVEETDVLDLYTELLTELSRLGIAYVHIEATADEELLVALRRVWPGTLVMNPVLPMGPKQTGREDADHWLGLGADLISFGRGFIANPDLVERLRTGLPVAPVDESTYYQGGDAGYLTYPAYQHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3E0</accession>
    <name>Q9F3E0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7617</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631658.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971527.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7617"/>
    <dbReference type="GeneID" id="1103055"/>
    <dbReference type="KEGG" id="sco:SCO7617"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7735"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067079_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F3E0"/>
    <dbReference type="OMA" id="QWLDIGT"/>
    <dbReference type="PhylomeDB" id="Q9F3E0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC16719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="29573" checksum="46A02DDC56BBD363" modified="2001-03-01" version="1">MSSTQGARSLDTSRPHSARMYDFYLGGKDHFPVDKQAAEAVAEAYPGIFTCARENRAFMHRATRVLAQEHGIRQWLDIGTGIPTEPNVHQVAQSVVPDARVVYADNDPLVLKYAERLMRSTPQGRTTYIEADVNDPDALLNAPELAEVLDLSRPVALSLNALMHFITDARDPYGIVDRLMAALPAGSALALSHCTPDFDPPTWEKVTDIYTGGGTPVQFRSQQDVARFFDGLDLLTPGVTVGHRWRPDLPAGPDAPTDAQVSLWAGVGIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBT9</accession>
    <name>Q9FBT9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7152</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631211.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031464.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7152"/>
    <dbReference type="GeneID" id="1102590"/>
    <dbReference type="KEGG" id="sco:SCO7152"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7253"/>
    <dbReference type="eggNOG" id="ENOG502ZHPD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015337_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="30424" checksum="68A5573294C3D86C" modified="2001-03-01" version="1">MTTLNLTLLGALREITAAELPPVTSAHSGRPLRRYALQLHVPDERHQELDAELRAAATPDGDHLQGSDAAWRVSEGWTASSQGRRPEIYVYRIEIQEVEILYAEALEVGGVRIVPGMYRERADEDTITVTVVAELSGEDDEHLEELLREPGAWYDVTRRGISDTPVRMRFGRCVWQRTEEGGRRHHLELVGDEGSPETAPSALDLAARPRLDRALEQVAAHTDALSRLLEELSAGGVLSEGAVKAVEAAAAPRPLTPREQRELSRTDRLSDYWS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-25" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCC1</accession>
    <name>BIOD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="1">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DTB synthetase</fullName>
            <shortName evidence="1">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioD</name>
        <name type="ordered locus">SCO1246</name>
        <name type="ORF">2SCG1.21</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625534.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027666.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCC1"/>
    <dbReference type="SMR" id="Q9FCC1"/>
    <dbReference type="STRING" id="100226.SCO1246"/>
    <dbReference type="GeneID" id="1096669"/>
    <dbReference type="KEGG" id="sco:SCO1246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1246"/>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FCC1"/>
    <dbReference type="OMA" id="SPHWAAE"/>
    <dbReference type="PhylomeDB" id="Q9FCC1"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187991" description="ATP-dependent dethiobiotin synthetase BioD">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <sequence length="238" mass="23587" checksum="819341CF4E722C7B" modified="2001-03-01" version="1">MPVLVITGTGTEVGKTVVTAAVAAAALAGGRTVAVLKAAQTGVGPDEAGDAQEVARLAGTATVAEVARFPDPLAPGTAARRAGRTPVRPEEVAEAATKLATEHDLVLVEGAGGLLVRFDAEGGTLADVAGLLDAPVLLVTSAGLGTLNTTELTARELRSRGLELPGLVIGSWPGAPDLAARCNLADLPDVSGAPLLGAVPAGAGSLSPAAFRSAAPHWLAPPLDGTWDADAFGDRHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCM0</accession>
    <name>Q9FCM0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7794</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631825.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031918.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7794"/>
    <dbReference type="GeneID" id="1103232"/>
    <dbReference type="KEGG" id="sco:SCO7794"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7910"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069543_2_1_11"/>
    <dbReference type="OMA" id="YHQGARI"/>
    <dbReference type="PhylomeDB" id="Q9FCM0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC04106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="23715" checksum="F0159ACA025668B9" modified="2001-03-01" version="1">MTKGITRERIVTAALELLDDQGMDALTVRTLASRLDVRPSALYWHVRNKQELLDEMATEVMRRVADALAAVLPGDGWRDDLAAYGRVLRSEYLLHRDGARIFSGTRITDPDVVRMKEPLFERWTASGWKPADADDAIDLVTAFAVGFVIEEQERRQAAGADPSRYSIDQRDAWLGEGAPLVKEAGHLHDDGDRRFERLLGMVLDGIGARLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3I3</accession>
    <name>Q9K3I3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1257</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625544.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027674.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1257"/>
    <dbReference type="GeneID" id="1096680"/>
    <dbReference type="KEGG" id="sco:SCO1257"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1257"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051674_4_1_11"/>
    <dbReference type="OMA" id="AGVLYHP"/>
    <dbReference type="PhylomeDB" id="Q9K3I3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB99137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="241" mass="24560" checksum="300F70FACD254926" modified="2000-10-01" version="1">MNLTPVLRAEALKVLTLRSLCGTLLSLSVVTTAFSALAGSSDASAPDFDPLFTALSGVMPGQIAAIAFGALVVSSEYQGSGIRLSLAAVPQRGRWFAAKLAVIAVPALVVGLATALAALLAARTGLGTAADGLSTGEQVRGVVGCGLYLMLMALFAAGLTTLFRSGVATLSTLIPFILVVSFVIGDAAGAAADFLPDQAGQIVLYQTHEGTLGPWTGLAVTALWAAAALLAGYWRLRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X6</accession>
    <name>Q9K3X6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1358</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625643.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027744.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1358"/>
    <dbReference type="GeneID" id="1096781"/>
    <dbReference type="KEGG" id="sco:SCO1358"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1366"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_0_11"/>
    <dbReference type="InParanoid" id="Q9K3X6"/>
    <dbReference type="OMA" id="HRAGETH"/>
    <dbReference type="PhylomeDB" id="Q9K3X6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="32772" checksum="740BB6D984B98F1D" modified="2000-10-01" version="1">MLNLERLRTLDALARHGSVSGAAAGLHITTSAVSQQMAKLEREAGQRLLAKNGRGVRLTDAGRLLAEHAARILSQVELAQADLEAQRGQVAGELRLSAFPTAARGLFPAALAALRAEHPALRIRSSELEPERGINGVVRGDLDLAVVLDWYNKPMPLPDGLVKAPLLDDPADVALPVGHRLAGRDEVDLAEFAEDEWITWGEGEFCHEWLMFTLRSKGIEPIVGHRAAETHTQLGLVAAGLGVCIAPLLGRHPMPAAVVTVPLRQRVRRHVYVVWRADADRRPSIRAAVDALRAAAREVGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K427</accession>
    <name>Q9K427_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1072</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625366.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027560.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1072"/>
    <dbReference type="GeneID" id="1096495"/>
    <dbReference type="KEGG" id="sco:SCO1072"/>
    <dbReference type="HOGENOM" id="CLU_2703131_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="73" mass="7094" checksum="1F0C913FC95AA3EB" modified="2000-10-01" version="1">MVGARRADRTGEAARRVADGSAPQAALAATAPGGGSGGGGKRRRPSGGPAGPRLGGTTGSARSVLRCCRPVRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-09-19" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4A0</accession>
    <name>DEF4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide deformylase 4</fullName>
            <shortName evidence="1">PDF 4</shortName>
            <ecNumber evidence="1">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polypeptide deformylase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">def4</name>
        <name type="ordered locus">SCO5221</name>
        <name type="ORF">SC7E4.18</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629368.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973751.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4A0"/>
    <dbReference type="SMR" id="Q9K4A0"/>
    <dbReference type="STRING" id="100226.SCO5221"/>
    <dbReference type="GeneID" id="1100662"/>
    <dbReference type="KEGG" id="sco:SCO5221"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5305"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K4A0"/>
    <dbReference type="OMA" id="WRERGTS"/>
    <dbReference type="PhylomeDB" id="Q9K4A0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043686">
        <property type="term" value="P:co-translational protein modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031365">
        <property type="term" value="P:N-terminal protein amino acid modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018206">
        <property type="term" value="P:peptidyl-methionine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000082855" description="Peptide deformylase 4">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <sequence length="216" mass="24184" checksum="562FDF5C60732AAF" modified="2000-10-01" version="1">MAQQDTDQQHPGVLPVDDEGFVVDSQDCEEREADWRGRGTSRPITVVGNPVLHKECEDVTDFGEEFQQLVADMFASQRTAEGVGLAANQIGVSKKVFVYDCPDDEGVRHVGVVCNPRLVELPADRRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPVKVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4L7</accession>
    <name>Q9K4L7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7297</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631352.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031573.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7297"/>
    <dbReference type="GeneID" id="1102735"/>
    <dbReference type="KEGG" id="sco:SCO7297"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7399"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_81_11"/>
    <dbReference type="InParanoid" id="Q9K4L7"/>
    <dbReference type="OMA" id="MREWFPM"/>
    <dbReference type="PhylomeDB" id="Q9K4L7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="497" mass="54564" checksum="81CD86842D7AAB2B" modified="2000-10-01" version="1">MSGRPMPCSPEEIGKLFLFEKLTPEQLGRLCAEGRVELFDPGPVYAEGEDATCFYVMLAGTVVLSRRVGADDVETNRTSQPGVYAGAMQAYVGDRVPQVYNNSMRVTEPTRFFVLPADTFAAVMREWFPMAVHLLEGLFFGSKNTQRAIGQRERLLALGSLSAGLTHELNNPAAAAVRATSTLRERVAKMRHKLAVIAEGPFSREALAGLIEIQERTAERVAKAPSLSPLEAADREDDLGDWLEDHGIEHGWQLAPTFVQAGLDTEWLEQVAAAVDEEILPGAVGWLNYTVETELLMNEIADSTARISHLVDAAKQYAQLDRAPYRTVDVHELLDSTLLMLSGKIGPRIEVVKEYERTVPRVPAYPAELNQVWTNLIDNAVAAVNDAGGEGTLTVRTALHHDRLLVEFRDTGTGIDPEIRERIFDPFFTTKPVGEGTGLGLDISWRIVVDKHHGSLQVESVPGDTRFQVLLPLTAAEPDPADPTDPTDPTDPTEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4M0</accession>
    <name>Q9K4M0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7294</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631349.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031571.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7294"/>
    <dbReference type="GeneID" id="1102732"/>
    <dbReference type="KEGG" id="sco:SCO7294"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7396"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055120_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4M0"/>
    <dbReference type="OMA" id="GTYWTQL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="318"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="434" mass="44895" checksum="47F6C3EAB51620EF" modified="2000-10-01" version="1">MSDLVPGGNVPLPGGPVSVRVPGGFDVSALVTDEGGKVGGDADFVFYNQPEAPGARLRDDTLTVDPARLRRGAARVTVAVGPSDPGTPLGALPSPTVLVTDARGRTVARFTPARPGRETVLLLVEFYRRGEGWKVRALGQGYADGLAGLARDFGVEVTDDAPPEPATAPEPLTPGADSDGFLNLVNSARAAAGSPAVRPDPRLRSAARAHAAAMAAAGTLSIETRDGVSVHQRVVSAGFAYLTVGEHLVSGPRTPAEFVAYCLRAERTRRTLHDTAFTHAGWACVTGGPSGDTYWTALWAVPLTPDGLARTTAEVVGLTNRERAGAGLPALAVDARLTAAAQAHSADMVTRDFYSHTDPDGGKPWDRAAAAGADRRSVGENIACGQRSPAEVVEGWMNSPGHRANILEAGFTHIGVGLAGGGRAGTYWTQLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KIL8</accession>
    <accession>Q7AKH1</accession>
    <name>Q9KIL8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F58a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">f58a</name>
        <name evidence="3" type="ordered locus">SCO5171</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2000-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kormanec J."/>
                <person name="Sevcikova B."/>
                <person name="Homerova D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">M145</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF230490">
        <property type="protein sequence ID" value="AAF82062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629319.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973806.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5171"/>
    <dbReference type="GeneID" id="1100612"/>
    <dbReference type="KEGG" id="sco:SCO5171"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5254"/>
    <dbReference type="eggNOG" id="ENOG502ZVB4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176356_0_0_11"/>
    <dbReference type="OMA" id="EADRMEQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF82062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="75" mass="8264" checksum="392569EF4D29B941" modified="2000-10-01" version="1">MTVDPTDPETFDDEAQAPDPEDRDVEAPDADAAEQRADVGQERDAPLTGVEPDRADEADLAEQARVVPHDEDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY72</accession>
    <name>Q9KY72_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component system DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4792</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB92655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628949.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029866.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4792"/>
    <dbReference type="GeneID" id="1100233"/>
    <dbReference type="KEGG" id="sco:SCO4792"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4868"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9KY72"/>
    <dbReference type="OMA" id="NVLRKTQ"/>
    <dbReference type="PhylomeDB" id="Q9KY72"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
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    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="36"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB92655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="251" mass="26868" checksum="BA487090117E3EE6" modified="2000-10-01" version="1">MSDPTEANGTAGTAGAGEAARPAQPAGDGAGERRVRVVLVDDHRMFRTGVQAEIGQTAETGVEVVGEAADVDQAVTVITATRPEVVLLDVHLPGGGGVEVLRRCAPLMSDAERPVRFLALSVSDAAEDVIGVIRGGARGYVTKTITGTDLVDSVFRVQEGDAVFSPRLAGFVLDAFASTDAPPVDEDLDRLTQREREVLRLIARGYAYKEIAKQLYISVKTVESHVSAVLRKLQLSNRHELTRWATARRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY97</accession>
    <name>Q9KY97_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical proten SCK15.07</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5005</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629157.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029998.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5005"/>
    <dbReference type="DNASU" id="1100446"/>
    <dbReference type="GeneID" id="1100446"/>
    <dbReference type="KEGG" id="sco:SCO5005"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5084"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101260_0_0_11"/>
    <dbReference type="OMA" id="MNSRQRR"/>
    <dbReference type="PhylomeDB" id="Q9KY97"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="21998" checksum="31C8D2C0C032CB83" modified="2000-10-01" version="1">MKSKVGPEVTAYRVKSDIEPYTELGATQFEKVEMPERWLSENAVTDLSRVRGKIAVTTLKAGSLLQTDMIVDTPALRPGQQEVAIMIDAATGVAGKITPGSTVNVYATFEGPREGDPDQSKIIVTGAKVIDVGELTSLEPDEDSRDREPTDAVPITFALSTIDAQRITYAESFARRVRLALVAPGGDTTVPDKDRTYELAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYE6</accession>
    <name>Q9KYE6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4124</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628302.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029451.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4124"/>
    <dbReference type="GeneID" id="1099564"/>
    <dbReference type="KEGG" id="sco:SCO4124"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4186"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9KYE6"/>
    <dbReference type="OMA" id="WRVHLHL"/>
    <dbReference type="PhylomeDB" id="Q9KYE6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="356"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB92377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="456" mass="49179" checksum="6431C71FCBB87FD9" modified="2000-10-01" version="1">MPATVIPGYYAPHLIYGPRTDARPARTPDHGRMEPVKPVPEDRAAEPVTEYVQRVNRRIRAFDHRHPLLWDLTLTGFWVLAALVDGTGDGWRSVAHDPGVPVGLVLVLSLALSVPVVWRRSHPRGALLLTLPAALVSAWSGAALQAALLQLLLVHHIALRLPLRNLWWAVAVVAAPTCVSVARYGDSAGSWNQQLGSQLVAIGVAALIGITVRTRRGYTEALEDRARRLETERDQQVRLAAAAERARIAREMHDIIGHNLSVITGLADGGRYAAAKSPDRAAQALDAIGTTSRQALGELRRLLDVLRDDDQDGTGPEPELAPQPALTDLDRLLDGVRRAGLPVRTTVKGEPALPEGRQLTLYRVIQEALTNTLKHAGPDATAHIELSYGSGGAATLTVTDTGRTAPLPSRTPSGGRGLPGMRERTSLYGGTLEAGPRPAPEQGWRVHLHLPEESPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYR8</accession>
    <name>Q9KYR8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629825.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973329.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5697"/>
    <dbReference type="GeneID" id="1101136"/>
    <dbReference type="KEGG" id="sco:SCO5697"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5786"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086566_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYR8"/>
    <dbReference type="OMA" id="CVAMFTE"/>
    <dbReference type="PhylomeDB" id="Q9KYR8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="145"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB91133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="31277" checksum="B36EF9AF254F378B" modified="2000-10-01" version="1">MRPPHVLTQTTSRVLEPSDLDAALAILDRDPVANAFVTARVQIAGLDPWRLGGEMWGWYEHGMLTSLCYAGANLVPICATQRAVRAFADRARRAGRRCSSIVGPAGPTAQLWRLLEPGWGPAREVRTHQPLMVADRLPDDMAPDPYVRRVRKDEVERIMPACVAMFTEEVGISPMAGDGGLLYQARVAELVGSGRSFARFDADGKVVFKAEIGAATDRACQIQGVWVAPEYRGKGLAAPGMAAVLRYALTDVAPVASLYVNDFNTAARRTYLRVGFQEVGAFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYS5</accession>
    <name>Q9KYS5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5690</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB91126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629818.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5690"/>
    <dbReference type="CAZy" id="GH95">
        <property type="family name" value="Glycoside Hydrolase Family 95"/>
    </dbReference>
    <dbReference type="GeneID" id="1101129"/>
    <dbReference type="KEGG" id="sco:SCO5690"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5779"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004617_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYS5"/>
    <dbReference type="OMA" id="WTAGADW"/>
    <dbReference type="PhylomeDB" id="Q9KYS5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB91126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="747" mass="81233" checksum="47046DEB94FF6AE6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYX2</accession>
    <name>Q9KYX2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ordered locus">SCO3009</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975803.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3009"/>
    <dbReference type="GeneID" id="1098442"/>
    <dbReference type="KEGG" id="sco:SCO3009"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3068"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYX2"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="PhylomeDB" id="Q9KYX2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB90920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="27894" checksum="D6EA8F0EC017183F" modified="2000-10-01" version="1">MDRNLVQKGDAPPSKRSDPGTEFCVDIVVKGRKTEVPERFRKHVAEKLKLEKIQKLDGKVISLDVEVSKEPNPRQADRCDRVEITLRSRGPVIRAEAAASDPYAALDLAAEKLGARLRKQHDKRFSRRGARRISAAEVADHVPGAATLNGNGDVVPTEKQDGVPTKKIGSLEVQGDGPLVVREKTHVAAPMSLDQALYEMELVGHDFYLFVDSETKEPSVVYRRHAYDYGVIHLTTDTMVTQAHAPDAGDALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ09</accession>
    <name>Q9KZ09_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2228</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626479.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028213.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2228"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1097661"/>
    <dbReference type="KEGG" id="sco:SCO2228"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2265"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_11"/>
    <dbReference type="InParanoid" id="Q9KZ09"/>
    <dbReference type="OMA" id="HATRFAN"/>
    <dbReference type="PhylomeDB" id="Q9KZ09"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="32"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB90876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="577" mass="63497" checksum="633D6BD94E477E29" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-13" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ75</accession>
    <name>HUTU_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urocanate hydratase</fullName>
            <shortName evidence="1">Urocanase</shortName>
            <ecNumber evidence="1">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutU</name>
        <name type="ordered locus">SCO3073</name>
        <name type="ORF">SCE25.14c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="1">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627293.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028751.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KZ75"/>
    <dbReference type="SMR" id="Q9KZ75"/>
    <dbReference type="STRING" id="100226.SCO3073"/>
    <dbReference type="GeneID" id="1098506"/>
    <dbReference type="KEGG" id="sco:SCO3073"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3133"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KZ75"/>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="PhylomeDB" id="Q9KZ75"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:histidine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000207361" description="Urocanate hydratase">
        <location>
            <begin position="1"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="572" mass="61262" checksum="BE0A810D8AE8804F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZA4</accession>
    <name>Q9KZA4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4842</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628997.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974129.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4842"/>
    <dbReference type="GeneID" id="1100283"/>
    <dbReference type="KEGG" id="sco:SCO4842"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4918"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032465_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZA4"/>
    <dbReference type="OMA" id="YTVAWID"/>
    <dbReference type="PhylomeDB" id="Q9KZA4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB89061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="457" mass="49321" checksum="82F16F00396EE57F" modified="2000-10-01" version="1">MSADTVPDADWGTVTGWGRTAPTAALLVRPRTYEEAAVAVRDCGARGGIARGLGRAYGDAAQNAGGAVLDMTALDRVHAVDVAGGTVLCDAGVSLHRLMEVLLPLGWFVPVTPGTRYVTVGGAIGADIHGKNHHVSGSFTRHVLSLELLTADGRVRTVAPGTPLFDATAGGMGLTGVILTATLRLQPVETALMSVDTERAGDLDDLMARLTATDHRYRYSVAWIDLLARGRATGRAVLTRGDHAPLDALPARSRARHAPLAFRTSRLPATPDFLPGGLLSRTTVGLFNEVWYRKAPRESRGRLQRIATFFHPLDGVPHWNRVYGRGGFVQYQFVVGHGREEALRRIVRRISARRCPSFLAVLKRFGAADPGWLSFPVPGWTLALDIPAGLPGLGAFLDELDEEVADAGGRVYLAKDSRLRPELLAAMYPRLDDFRALRAELDPRGVFVSDLARRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZR5</accession>
    <name>Q9KZR5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2886</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627114.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028646.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2886"/>
    <dbReference type="ESTHER" id="strco-SCE6.23C">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1098320"/>
    <dbReference type="KEGG" id="sco:SCO2886"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2946"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_11"/>
    <dbReference type="InParanoid" id="Q9KZR5"/>
    <dbReference type="OMA" id="SAFWITM"/>
    <dbReference type="PhylomeDB" id="Q9KZR5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="32818" checksum="694A0B1DBA774E86" modified="2000-10-01" version="1">MTTQRPRTYDPPRPRTVTVDGARVACWEAGPPDAEPVVLLHGYPADHRCWRHQVPPLSARHRVITPDLLGWGASDRPLHLSFDYDTEVARVGRLLDALDLDSVNLVGHDYGGFLSLGFTQNHPDRVRRLALLNTRAHGTFTRRWYAVFGLLGLLGRNPLLSGPARHLPYAALHRRSLAPLVRAGHLDARVVDGYLDWMAAPEGRRWLLHYFGDYRTPARPELRRRLSGITCPTAVVWGRADPYLSPAIATGLAGSVPRAELTMLDDAGHWVMDERPADVTRALGRLLERTTPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZZ5</accession>
    <name>Q9KZZ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4431</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628598.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974551.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4431"/>
    <dbReference type="GeneID" id="1099871"/>
    <dbReference type="KEGG" id="sco:SCO4431"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4500"/>
    <dbReference type="eggNOG" id="COG5472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110234_0_0_11"/>
    <dbReference type="OMA" id="GGEWFAM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018681">
        <property type="entry name" value="DUF2165_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09933">
        <property type="entry name" value="DUF2165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="18814" checksum="B7685780EC402D77" modified="2000-10-01" version="1">MTNIPRSTLLLASTVLTAVLALYIALVALGNITDFDNNQQYVHHVLAMDTTFKDDDLMWRAITSKGLQDTAYVAIIVWETAAALVLIWATWLWIRRQHAPARRFTTYGTLMLMLLFGAGFLAIGGEWFAMWQSEDWNGLDAATRVLLFSGVVLIVAHLPSGEAEATRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L087</accession>
    <name>Q9L087_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028364.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2459"/>
    <dbReference type="GeneID" id="1097893"/>
    <dbReference type="KEGG" id="sco:SCO2459"/>
    <dbReference type="eggNOG" id="ENOG5032WTP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129891_0_0_11"/>
    <dbReference type="OMA" id="PGAVAWF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB86124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="19753" checksum="564879A62989DF6B" modified="2000-10-01" version="1">MDAHLRPVQEGTGSRAEQWQDAPMGTTDSDRDRDRDSEVQYVRFQSPHRNSRGHFTGVFGLVNNLAREGRLSDEQETFRRGGNRWYDAAYTDPSTVDPHVYDDEINPGAAAWFKPSATHLLARVSGYLEILSSHGVACRALRSADPGRVIYEDDVQIVVVPHAPEATAAHENSHGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0G3</accession>
    <name>Q9L0G3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4679</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628838.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029810.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4679"/>
    <dbReference type="GeneID" id="1100120"/>
    <dbReference type="KEGG" id="sco:SCO4679"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4751"/>
    <dbReference type="HOGENOM" id="CLU_131550_2_1_11"/>
    <dbReference type="OMA" id="RLDWFKS"/>
    <dbReference type="PhylomeDB" id="Q9L0G3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB82047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="6997" checksum="FACC74F940E70485" modified="2000-10-01" version="1">MIRETEPVWFKSSYSSGTDGNSCVELAVTPATIHIRDSKHTDGPRLTLTPAAWSSFLPYASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0J4</accession>
    <name>Q9L0J4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lysR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4671</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628831.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029804.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4671"/>
    <dbReference type="GeneID" id="1100112"/>
    <dbReference type="KEGG" id="sco:SCO4671"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4743"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9L0J4"/>
    <dbReference type="OMA" id="DGCFADC"/>
    <dbReference type="PhylomeDB" id="Q9L0J4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB81862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="315" mass="33621" checksum="DDE41DDA287B854A" modified="2000-10-01" version="1">MELELRHLKTVRAIADAGSLTRAATALGLAQPALSAQLKRIERALGGALFVRGRHGVRATALGELVLERSRIVLPAVTELQQEAARFARAPRTAERLRIGGTHGPLLGALLDRLAGVAPDARMTTCTSWSERELAGQLAEGRLDFALAGTCGTASPPAGEGLVWREVAVDPVFVMMTDGHPLAHRAEVDLTALADEEWACVPGDGCFGDCFTASCARAGFTPRRMYETDTASLVHLVQVGRAVGLCRATFPTTPGIVTRPLADTPLTWRHLLGWHAATQRRDTAAAVLAQARMAHASVAANSDSYTEWMSAHRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0M2</accession>
    <name>Q9L0M2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4638</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628799.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029786.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4638"/>
    <dbReference type="GeneID" id="1100079"/>
    <dbReference type="KEGG" id="sco:SCO4638"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4709"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_7_1_11"/>
    <dbReference type="InParanoid" id="Q9L0M2"/>
    <dbReference type="OMA" id="FEAWDPA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB77412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="29696" checksum="4792168334F62914" modified="2000-10-01" version="1">MPTLSSPEPPEQPPSHQARETAESFGADAQRYDRARPPYPDALVTRVVAGSPGTDVLDVGCGTGIAARQFRAAGCAVLGVEPDARMAAFARDRGLPVEVAAFEAWDPAGRAFDAVIAAQSWHWVDPAAGAVKAAQVLRPDGRLAIFGHVYEPPAEVAEPFAAAYRRAAPESPFSDQPARRPLEMYLAGYAQIADRIRASGRFHEPEQWRFDWERSYTRDEWLELLPTTGGLTRLRPGQLAGILDAVGRAVDALGGRFTMRYTTLATTAVRAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0P2</accession>
    <name>Q9L0P2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4249</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628423.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029530.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4249"/>
    <dbReference type="GeneID" id="1099689"/>
    <dbReference type="KEGG" id="sco:SCO4249"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4313"/>
    <dbReference type="HOGENOM" id="CLU_1194320_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="232" mass="21001" checksum="C1264DB4A849059B" modified="2000-10-01" version="1">MYAGGGPSGGGAPAPASYGGGGSLYGGGGSSGPGRDGGGSSRVRLSTTVAAVAEARAAVVCPARRERRKENRWTGGMSPDTAPGGAVSGVVSAGPACVATGISGRAADGRGGVSGATGSGAPVEAPGDTGLRRGTALAGARWTTGGAAPPPPGSAGGVRCGAAGAASVAAAAKGGTADVARAAKGGVADVAGGVRAVKGGVADVAAAVVVAVKGGVVGAKAWAVARCTGGGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1A3</accession>
    <name>ARGB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name type="ordered locus">SCO1578</name>
        <name type="ORF">SCL24.14c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625855.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977246.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L1A3"/>
    <dbReference type="SMR" id="Q9L1A3"/>
    <dbReference type="STRING" id="100226.SCO1578"/>
    <dbReference type="GeneID" id="1097009"/>
    <dbReference type="KEGG" id="sco:SCO1578"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1590"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_0_1_11"/>
    <dbReference type="InParanoid" id="Q9L1A3"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="PhylomeDB" id="Q9L1A3"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112672" description="Acetylglutamate kinase">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <sequence length="306" mass="32464" checksum="D914478E9655A9CB" modified="2000-10-01" version="1">MSDGTSNAPTRKHTALPKAQILIEALPWLTRHHGKTVVIKFGGNAMIDEDLKAAFAQDVVFLRHAGLKPVVVHGGGPQISAALDKHGIVSEFKAGLRVTTEDAMDVVRMVLAGQVQRELVGLLNQHGPLAVGLTGEDAHTLTATKHQPEIDGELVDIGRVGEITEIDTGAIEALLADGRIPVVSSIARSQDDHHVYNVNADTAAAALAAALGAETLMVLTDVEGLYEDWPDSDEVISRLTASELEKLLPDLSSGMVPKMEGCLHAVRGGVTTARVIDGRVQHSILLEIFTDEGIGTMVVPDEQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1H5</accession>
    <name>Q9L1H5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626839.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028448.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2602"/>
    <dbReference type="GeneID" id="1098036"/>
    <dbReference type="KEGG" id="sco:SCO2602"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2648"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398464_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="568"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="707" mass="76880" checksum="3C8CB415ACFCC7BA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L244</accession>
    <name>Q9L244_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ordered locus">SCO2677</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626912.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028506.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L244"/>
    <dbReference type="STRING" id="100226.SCO2677"/>
    <dbReference type="GeneID" id="1098111"/>
    <dbReference type="KEGG" id="sco:SCO2677"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2732"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="InParanoid" id="Q9L244"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="PhylomeDB" id="Q9L244"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="315"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="547" mass="60683" checksum="19D3D174A28DB636" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L248</accession>
    <name>Q9L248_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2673</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626908.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028503.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2673"/>
    <dbReference type="TCDB" id="3.A.1.122.33">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1098107"/>
    <dbReference type="KEGG" id="sco:SCO2673"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2728"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013835_0_0_11"/>
    <dbReference type="OMA" id="QAWWSGR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004328710" evidence="7">
        <location>
            <begin position="34"/>
            <end position="907"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="800"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB71211.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="907" mass="92969" checksum="DA4390FAB035D808" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L281</accession>
    <name>Q9L281_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1528</name>
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    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="entry name" value="EFG_V-like"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ELONGATNFCT"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB70930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="732" mass="78155" checksum="547F9FED84290329" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2L5</accession>
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        <submittedName>
            <fullName evidence="5">PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2532</name>
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    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB66426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2532"/>
    <dbReference type="GeneID" id="1097966"/>
    <dbReference type="KEGG" id="sco:SCO2532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2577"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_2_1_11"/>
    <dbReference type="InParanoid" id="Q9L2L5"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="PhylomeDB" id="Q9L2L5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="128"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB66426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="39147" checksum="EAB26376BF0E45C7" modified="2000-10-01" version="1">MTQTPSAHTPAQGQASARITVPAQHPMVTVLGSGDSLLRVIEKAFPAADIHVRGNEISAVGDTHEVALVQRVFDEMMLVLRTGQPMTEDAVERSIAMLKASENGESDGQETPAEVLTQNILSSRGRTIRPKTLNQKRYVDAIDKHTIVFGIGPAGTGKTYLAMAKAVQALQSKQVNRIILTRPAVEAGERLGFLPGTLYEKIDPYLRPLYDALHDMLDPDSIPRLMAAGTIEVAPLAYMRGRTLNDAFIILDEAQNTSPEQMKMFLTRLGFESKIVITGDVTQVDLPGGTKSGLRQVQEILEGVEDVHFSRLTSHDVVRHKLVGRIVDAYEQYDSRNGTENGGHNGGRTPRHGAKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCX1</accession>
    <name>Q9RCX1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0939</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625237.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027458.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0939"/>
    <dbReference type="ESTHER" id="strco-SCM10.27c">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1096362"/>
    <dbReference type="KEGG" id="sco:SCO0939"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.935"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_11"/>
    <dbReference type="InParanoid" id="Q9RCX1"/>
    <dbReference type="OMA" id="AHYPNME"/>
    <dbReference type="PhylomeDB" id="Q9RCX1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="31103" checksum="C2FA947BD23A0247" modified="2000-05-01" version="1">MTPRLPKSTSHDTLVVMTAASDLRFFTSADGGLAYRDTGAGDPVVLLHSGFTDHRVFDDQIPALAREYRVIAPDVRGHGASANASRPFRWADDLAALLRHLDTGPAVLVGVSMGGAIATDTVIEYPELVRAVVACGASTSEFEYTDPWVRQVQADQARALGAGDVEGWLTAFLRFVPGEHRTLDDVDPDVLRRVREMALGTLTKHTPDEVNHHVPLTGTWARVPKIDVPVLAVNGALDAPDLIAEAERLARTVPDGRSTLVEGVAHYPNMERPEVFTDIVSGFLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCY4</accession>
    <name>Q9RCY4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0926</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB63175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625224.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027450.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0926"/>
    <dbReference type="GeneID" id="1096349"/>
    <dbReference type="KEGG" id="sco:SCO0926"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.920"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_11"/>
    <dbReference type="InParanoid" id="Q9RCY4"/>
    <dbReference type="OMA" id="SENWARA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="31417" checksum="DC01CA507FD38960" modified="2000-05-01" version="1">MIVITTPTGGIGRQVLDNVLDALGARDDGPALRVIARDPGRLTARTRERAEVFQGSHADPEVLGAACEGADQVFWLVPPAPGADSVEGHFRDFTLPLCEVIARRDVARVVAVSSLGRGVAKDAGPISASLAMDDRIAATGVHYRALCPPFLMENLLGQAAALRDTGEFRMAYAADRVLRTCATADIAATAARLLLDDSWTGRADVPLVGPDDLTPEGMAEVLADVLGRPVRVRETTPEAYKASALRFGASESGAQGLADMASAMDAQGFYGAAEPSTPDTASTSFGRWCEEVLRPATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD68</accession>
    <name>Q9RD68_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0809</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625110.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978051.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0809"/>
    <dbReference type="GeneID" id="1096232"/>
    <dbReference type="KEGG" id="sco:SCO0809"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.801"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RD68"/>
    <dbReference type="OMA" id="KRMLKMH"/>
    <dbReference type="PhylomeDB" id="Q9RD68"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB66209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="34645" checksum="9AB9B882EB2B91C6" modified="2000-05-01" version="1">MADTSLTRAVRWDTVVGALLVVVLLLSFGFVDGFGNALNLSFLIGNTLPIALIALPMTLLVVSGEIDLSVASTAGLSGAVMGALWNQGMTIETIIPICLLLGVVCGLVNGLLVTRLGLPSLAVTIGTMAAYRGIAQIVLGSDAVTDFPSQYLDFAAGRIDGTFVPYAFLPFLVLLAVAVVALHAMPFGRSLFAIGASEEAARFAGIRVKRQKLILFTLTGLMSSLTGVFWALHYASARYDNATGLELSVVAAVLLGGIDFDGGKGTLGGAIAGVFLLGALQNVMSLQDVSAQSQIVVTGVLLVLSVLGPRVARQISLARAGRGAAPAPPSKAPAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDA2</accession>
    <name>Q9RDA2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2849</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627078.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975951.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2849"/>
    <dbReference type="GeneID" id="1098283"/>
    <dbReference type="KEGG" id="sco:SCO2849"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2908"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079072_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDA2"/>
    <dbReference type="OMA" id="ANYLNSW"/>
    <dbReference type="PhylomeDB" id="Q9RDA2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="31380" checksum="8DD94A5AC0EB5086" modified="2000-05-01" version="1">MNEATASLKESVGRYGVWSVQLRAEDPEGAAERAEAAAELERLGYGALWLGGNSAARHAAPLIRATERIVVGTSIQSIWEHKPSEAAAGFAELEVSHPGRFVLGLGVSHGPRVEGYRRPYSTMVGYLDELDRAGMRSGHRVLAALGPKMLDLSRDRAAGAIPYLVTPEHTAQARERLGEGPLLAPEFKVVLDADPSRARATARAYLAMYLKLPNYTKNFLNLGFTDDDVTGGGSDRLIDAVFAWGDEATIRARIDAFHAAGADHVALQLVTDDMARLPREGWRRLAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDC7</accession>
    <name>Q9RDC7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2496</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626737.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976306.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1097930"/>
    <dbReference type="KEGG" id="sco:SCO2496"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2541"/>
    <dbReference type="eggNOG" id="ENOG502ZE5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776356_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176867" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="16155" checksum="FEAF21EAC9BF9265" modified="2000-05-01" version="1">MKKRTACVAALSAATLAVLPLAATASAAEYTVTYVGVRHEGDVCTSHNWTHDCNGSASFVHDGDHLLVWDNAADGHSVVVEYLRSDENGDDYLRAWNYYGKYDRLDVNMNLAEDGGYISYRVCLGEYGTREVLSDTCSPFNFEWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDD5</accession>
    <name>Q9RDD5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2556</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626794.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028425.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2556"/>
    <dbReference type="GeneID" id="1097990"/>
    <dbReference type="KEGG" id="sco:SCO2556"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2601"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_5_0_11"/>
    <dbReference type="InParanoid" id="Q9RDD5"/>
    <dbReference type="OMA" id="NVGPGHT"/>
    <dbReference type="PhylomeDB" id="Q9RDD5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="25559" checksum="6773E6B4A906A1C7" modified="2000-05-01" version="1">MTVTWEELGWERLADGVGRCRLPGWDCTAGLVLGADAALMVDAGSSLDEGARLREGARRLAGRRVTHLALTHPHFDHVFGAAAFTGAEVYGAYGAAGTGALFAPGGQGRQALRADAVAEGLDSRAAREAAEALSPVRHEVRGEQPLDLGGGRRVLLADAGPGHTGHDLAVLVPGSPDVLFCGDLVEESGEPQAGPDAVPSHWPAALDRLLELGGDDALYVPGHGAVVDAAFVRVQRDALAARFGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDG7</accession>
    <name>Q9RDG7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted tripeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2761</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626992.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028568.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2761"/>
    <dbReference type="ESTHER" id="strco-SCO2761">
        <property type="family name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="MEROPS" id="S37.001"/>
    <dbReference type="GeneID" id="1098195"/>
    <dbReference type="KEGG" id="sco:SCO2761"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2818"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039283_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RDG7"/>
    <dbReference type="OMA" id="TPYYYQA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176871" evidence="1">
        <location>
            <begin position="24"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="474" mass="53470" checksum="2B3CD96C8BB38EE1" modified="2000-05-01" version="1">MRKALRWLLALVVLIGTVSTAGAATAAEPKAVDIKDRLLSIPGMSLIEEKPYTGYRFFVLNYTQPVDHRHPSKGTFQQRITVLHKDVNRPTVFYTGGYNVSTNPSRREPTQIVDGNQVSMEYRYFTPSRPAPADWSKLDIWQAASDQHRIFKALKPLYSKNWISTGGSKGGMTATYYERFYPRDMDGVVAYVAPNDVVNKEDSAYDRFFARVGTDECRDKLNGVQREALVRRAPLEKKYAAYAAENGYTFDTIGSLDRAYEAVVLDYVWGFWQYSTLADCADIPADAKNATDDAIWGSVDAISGFSAYTDQGLETYTPYYYQAGTQLGAPTIHFPHIEKKYIRYGYQPPRNFVPRSIPMKFEPWAMRDVDTWVRHNARHMLFVYGENDPWGAERFRLGHGARDSYVLTAPGMNHGANVAGLVPDQKARATARILDWAGVAPAKVQENPSAARPLATFDARLDQRDVEREPALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ51</accession>
    <name>Q9RJ51_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PmbA_TldD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1817</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027992.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1817"/>
    <dbReference type="GeneID" id="1097251"/>
    <dbReference type="KEGG" id="sco:SCO1817"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1838"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046126_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ51"/>
    <dbReference type="OMA" id="TCLWYIR"/>
    <dbReference type="PhylomeDB" id="Q9RJ51"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="227"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="464" mass="49477" checksum="F29D98DBE2D3D175" modified="2000-05-01" version="1">MSVRSSKPHEVVERALELSRADGCVVIADEESTANLRWAGNTLTTNGVTRGRTLTVVATVDGREGTASGVVSRSAVTLDELEPLVRAAEAAARNAGPAEDAQPLVTGGAAAPDFTDAPAETSSAVFADFAPALGEAFARARAGDRELYGFANHEMTSTYVGTSTGLRLRHDQPNGTLELNAKSPDRTRSAWAGRATRDFKDVDPAALDAELAVRLGWAERRVELPAGRYETLLPPTAVADLLIYQYWSASGRDAVEGRTVFSKPGGTRVGERLGTLPLTLRSDPHEPGLESAPFVVAHSSGGDQSVFDNGLPVAATDWIRDGELHRLTTTRHSAGLTGLPVAPAIGNLVLDGGDPDRSLDEMVAGTERGLLLTCLWYIREVDPATLLLTGLTRDGVYLVEHGEVVGEVNNFRFNESPVGLLGRASEAGRTEKTLPREWGDWFTRTAMPALRVPDFNMSSVSQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ97</accession>
    <name>Q9RJ97_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0668</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624977.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0668"/>
    <dbReference type="GeneID" id="1096091"/>
    <dbReference type="KEGG" id="sco:SCO0668"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.652"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ97"/>
    <dbReference type="OMA" id="PRCHDEV"/>
    <dbReference type="PhylomeDB" id="Q9RJ97"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="95"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="530" mass="55843" checksum="EAD4DA1B51EE9C8E" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJP2</accession>
    <name>Q9RJP2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0602</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624914.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027237.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0602"/>
    <dbReference type="GeneID" id="1096025"/>
    <dbReference type="KEGG" id="sco:SCO0602"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.584"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048411_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJP2"/>
    <dbReference type="OMA" id="LYLAHHD"/>
    <dbReference type="PhylomeDB" id="Q9RJP2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="373" mass="42190" checksum="313D32E99EEAEA58" modified="2000-05-01" version="1">MSCRLKPITREEHLRFVAARPSVSHLQVPSWGDVKPDWRAESLGWFDEGGELVGAGLVLLRPLPRLKRYLAYLPEGPVIDWSADGLERWLEPMLAHLRGRGAFTVRMGPPVVARRWSAEAVKAAIADPGARRLGDVEATEHEPGADALAERLRRMGWRRTEPGGADGFAAGQPRHVCQVPLAGRSLEQLQNGFNQQWRRNIKKADKAGVKVVRGDQEDLPVFYELYVETARRDRFAPRPLAYFQRMWQALTAEDPDRMRLYLAHHDGEVLAAATMLTVGEHVWYSYGASTGRRREVQPNNALQWRMMCDARELGAAVYDFRGITDTLDEDNHLLGLLRFKVGAGGKAVEYLGEWEYPLNRVLHKAVALYLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJP6</accession>
    <name>Q9RJP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624906.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027230.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RJP6"/>
    <dbReference type="STRING" id="100226.SCO0594"/>
    <dbReference type="GeneID" id="1096017"/>
    <dbReference type="KEGG" id="sco:SCO0594"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.575"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_7_4_11"/>
    <dbReference type="InParanoid" id="Q9RJP6"/>
    <dbReference type="OMA" id="HLVFETR"/>
    <dbReference type="PhylomeDB" id="Q9RJP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26756" checksum="6BC0F3D8E08277CF" modified="2000-05-01" version="1">MADESFRHPRLAALYDVLDTDRGDLVPYLLMAGEFGARSVLDIGCGTGVFALLLADRGLEVVGVDPAGASLDVARGREGADRVRWIEGDATSLPALRVDLATMTANVAQAITGRSAWQGTLRGAYEALRPGGHLVFETRDPARRAWEEWTREHTHQVVEVPGTGTVESWCRLLDVSGPLVTFRWTYVFGADGAVLTSDSTLRFRERDEVAADLAEQGYVVQEVRGALDRAGREFVFVARRPQAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJV2</accession>
    <name>Q9RJV2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0358</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624681.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027050.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0358"/>
    <dbReference type="GeneID" id="1095781"/>
    <dbReference type="KEGG" id="sco:SCO0358"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.334"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RJV2"/>
    <dbReference type="OMA" id="EWLEYSF"/>
    <dbReference type="PhylomeDB" id="Q9RJV2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="40756" checksum="F2976885EE30AE52" modified="2000-05-01" version="1">MRITGYRSLATVHEWGRPVGDVNGVVTTGVTEVPVLLLETDEGLTGVGLGGHADVERVFPALEGQDPRAVTSLYDRMLAHVFKSGHGGHVFATIGALDMALWDLKAKIAQEPLWRTLGAADRFVPGYASGLDYALSDDELVAFHGRWARRGFTGAKVKGGLDVDRDVRRLAAVRDVFRVNSERPALMYDVNECWGRHQAVRLARQVEERVELTWIEEPVRRWDVAGHRAVATGIRAAVATGENLTGLEHFRPLLAADAVGVVQTGAVWGITHFLRVSTLAFGHGLPVSPVGYNANPVAHAAAAVPNHLVTEVQDLAFPVGLRVDQEIADGGIVLGDAPGLGIEVDEERIVARAASGGWSLPSGPHVRPADAGLRLAPQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK63</accession>
    <name>Q9RK63_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0547</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978316.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0547"/>
    <dbReference type="GeneID" id="1095970"/>
    <dbReference type="KEGG" id="sco:SCO0547"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.527"/>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833978_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RK63"/>
    <dbReference type="OMA" id="AFDLATY"/>
    <dbReference type="PhylomeDB" id="Q9RK63"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="333" mass="34448" checksum="31C28CFB7B26F4D0" modified="2000-05-01" version="1">MTDDRPAPTGGTPRTVLMCPGQGAYLPGALRHLSGVPSVSRVLGTVDAHGTALGSTRTPVGRLLTDSAAPDPDLLLRTDPLAFDLATYAAVVASAAVLLDLATPPVHAVLGHSVGDLAALTVAGVITIEQGVRLLHVRDRLLRDAALPAAGLLATDLSAEPAADLLRAEGLPQVRIAARNAPGQTVLAGPDDQLAAVRSAARALGRRATPLTSRTAYHHPLLAEVQRAFRRLLRAQPVAPPTLPVYTAAAPGPARTPAQLRTVAAAHLSEPLAFHRTLCALRLAGFTTYLDSGPRALLSTLARAGLPGCITAAPSRTPAGLDRIRLRLTAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK83</accession>
    <name>Q9RK83_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0526</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978337.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0526"/>
    <dbReference type="ESTHER" id="strco-SCF11.06">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1095949"/>
    <dbReference type="KEGG" id="sco:SCO0526"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.506"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_11"/>
    <dbReference type="InParanoid" id="Q9RK83"/>
    <dbReference type="OMA" id="HRIAWGT"/>
    <dbReference type="PhylomeDB" id="Q9RK83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="30371" checksum="8292B5B7DAE4D8E1" modified="2000-05-01" version="1">MSAWPLPEAFTGGSGTVRWNRLGAPDGRPLVLLHGTPFSSYVWRAVARSLGRDHQVFVWDMPGYGVSEKSAGQDVSLAAQGRVFTELLEHWGLEEPLVAAHDFGGAVALRAHLLHGARYGALALVDPVALAPWGSPFFRLVRDHAEVFEQLPEALHRALVREYVGSTGGPGLHPAVLDRLVEPWLGETGQPAFYRQIAQADQRYTDEIQDRYTGIDVPTLICWGEDDAWIPVAKGRELAGLVPGSRWEPIAHAGHLVQEDAPAELTAALLDFFRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKA2</accession>
    <name>Q9RKA2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0260</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624590.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978605.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0260"/>
    <dbReference type="GeneID" id="1095684"/>
    <dbReference type="KEGG" id="sco:SCO0260"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.233"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_7_0_11"/>
    <dbReference type="InParanoid" id="Q9RKA2"/>
    <dbReference type="OMA" id="GNLWFDW"/>
    <dbReference type="PhylomeDB" id="Q9RKA2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="109" mass="12162" checksum="F5434BD6AB881163" modified="2000-05-01" version="1">MIFITAKFRVLPEHADQWPQVVEDFTRATRAEPGCLWFDWSRSLDDPTEYVLVEAFRDDEAGAAHVGSAHFKAAQQTLPPHLATTPRIVNANVPQDDWSLLGEMAVDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKB1</accession>
    <name>Q9RKB1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3176</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627392.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028811.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3176"/>
    <dbReference type="GeneID" id="1098610"/>
    <dbReference type="KEGG" id="sco:SCO3176"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3236"/>
    <dbReference type="eggNOG" id="ENOG503426H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035909_0_0_11"/>
    <dbReference type="OMA" id="RCNFESE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176931" evidence="3">
        <location>
            <begin position="35"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="583" mass="59709" checksum="68F3A6C66EF23911" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKS9</accession>
    <name>Q9RKS9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6263</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
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                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
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                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
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        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
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        <location>
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            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
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        <location>
            <begin position="572"/>
            <end position="629"/>
        </location>
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            <begin position="776"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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            <end position="86"/>
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            <begin position="179"/>
            <end position="210"/>
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            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
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            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
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                <person name="Saunders D."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="284"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50901"/>
        </source>
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            <dbReference type="EMBL" id="CAB61675.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="582" mass="62252" checksum="03A5740BBD4445DF" modified="2000-05-01" version="1"> </sequence>
</entry>
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    <accession>Q9RL43</accession>
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            <fullName evidence="4">AHS2 domain-containing protein</fullName>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
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                <person name="Chen C.W."/>
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                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
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                <person name="Rutherford K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InParanoid" id="Q9RL43"/>
    <dbReference type="OMA" id="DDYAYSW"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="285" mass="28707" checksum="52983B41B8F52EB6" modified="2000-05-01" version="1">MTTRLTTVRAGALTTVQDAGRPGHAHLGVPRSGALDAPAMRLANRLLGNDPDTAVLETTLTGCALRPDRDVAAVVGGAPCAVTVDGRPAAWGAPVRVPAGSVLDVGTATGGVRSYVAVAGGIAAEPVLGSRSTDLLSGLGPTPLRDGDVLAVGAPARPAPPPVAAPWPGPPAELVLPVRPGPRADWFTPAALRTLTSAAYRVSPHSNRIGLRTEGPPLQRLSTGELPSEGMVLGAVQVPPDGRPVIFLHDHPTTGGYPVVAVVPEPALAAAAQAVAGTPVRFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL47</accession>
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            <fullName evidence="2">Putative membrane protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0439</name>
    </gene>
    <organism evidence="3">
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624760.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978427.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0439"/>
    <dbReference type="GeneID" id="1095862"/>
    <dbReference type="KEGG" id="sco:SCO0439"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.416"/>
    <dbReference type="eggNOG" id="COG3817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078249_0_0_11"/>
    <dbReference type="OMA" id="CWLTRDT"/>
    <dbReference type="PhylomeDB" id="Q9RL47"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="33708" checksum="401CC803D5504BEA" modified="2000-05-01" version="1">MIKVEWLYWLIGLVFVVMAVQMAMDRSNPKRWTSAAFWGLLGLTFPYGTGVANATAGNGGWTLPAEPLGVAVLALIVLAGFNFLGKGVPVTTTGEQREAAAARLGNKIFVPALTIPLVAIVCASVLDESGLFETGKATLLGLGLGCVAALVVGMLVTGEKKLSVPIHSGRSMLEAMGSALLLPQLLAVLGSIFAAAGVGDQVGDIMNKVLPDDSKYFAVLAYCVGMFLFTVIMGNAFAAFPVMTAAIGWPVLIQQMHGNEPAVLAIGMLAGFAGTLCTPMAANFNIVPATLLELKDQYGPIKAQLPTGIALLGCCTVIMALFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Z2</accession>
    <name>Q9S1Z2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0134</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37064">
        <property type="entry name" value="T37064"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624473.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978742.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095558"/>
    <dbReference type="KEGG" id="sco:SCO0134"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.111"/>
    <dbReference type="HOGENOM" id="CLU_180106_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="101" mass="10752" checksum="E0EA49CE6522558C" modified="2000-05-01" version="1">MALRATVRGRAPRPEARGGSITPGPGWQHVGGPFLSRAHCLTALAAYRAHDPGREYRYGTDGAGSWNVYLEALPTYGPDGTGTSSAGRGRPALRIVRPDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S233</accession>
    <name>Q9S233_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1767</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36870">
        <property type="entry name" value="T36870"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626038.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027962.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1767"/>
    <dbReference type="GeneID" id="1097198"/>
    <dbReference type="KEGG" id="sco:SCO1767"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1784"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_3_11"/>
    <dbReference type="InParanoid" id="Q9S233"/>
    <dbReference type="OMA" id="QVYETVW"/>
    <dbReference type="PhylomeDB" id="Q9S233"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB52831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="25862" checksum="828EEF9867ED9EB4" modified="2000-05-01" version="1">MHGYDKHAFEPFAVTVDLAVLTLRAGALHALLVERGQEPYAGRWALPGGFLLPAESAEEAARRELAEETGLADVTGLHLEQLRTYSEPGRDPRMRVVSVAFAALLPDPPEPHGGGDAAEARWVPYDKAQGLAFDHDRILADARDRVGAKLEYTCLATAFCPAEFTLGELQQVYETVWGTALDRPNFRRKVLATPGFVEPVPGAARLTGGRGKPAAVYRAGPATTLHPPLLRTPREGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2A7</accession>
    <name>Q9S2A7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1723</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36745">
        <property type="entry name" value="T36745"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625996.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1723"/>
    <dbReference type="GeneID" id="1097154"/>
    <dbReference type="KEGG" id="sco:SCO1723"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1740"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_9_3_11"/>
    <dbReference type="InParanoid" id="Q9S2A7"/>
    <dbReference type="OMA" id="WLMTISH"/>
    <dbReference type="PhylomeDB" id="Q9S2A7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB50938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="20857" checksum="6EB4E6F49ACA7591" modified="2000-05-01" version="1">MAGDRVAADELLVLVADGDQQAFEELYGLVSGPVFGLVRRVVRDPAQSEEVAQEVLLELWRSAARFDPRRGSALSWILTVAHRRAVDRVRSARAAGERDRREAHRSHHPAFDQVSEEVEAELEREWVRGCLDRLTALQRQSVTLAYYDGYTYREVAERLSLPLGTVKTRMRDGLGRLRECLGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2G6</accession>
    <name>Q9S2G6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2915</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB50996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36138">
        <property type="entry name" value="T36138"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627141.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975896.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2915"/>
    <dbReference type="GeneID" id="1098348"/>
    <dbReference type="KEGG" id="sco:SCO2915"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2973"/>
    <dbReference type="eggNOG" id="ENOG5032Z6K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087287_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2G6"/>
    <dbReference type="OMA" id="KPMVMAY"/>
    <dbReference type="PhylomeDB" id="Q9S2G6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="2">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB50996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="202" mass="21914" checksum="6CF46B1DC1A881A8" modified="2000-05-01" version="1">MPGQFEPLPGGGAAVALDDVEISIIRSLAVQLLELIGPGPAEDASDDPLAELFAEGPSEPPSDPVLRRLFPDAYGDPEGAPQAREAEEQRAHSAEFRRYTENDLRAGKRDNALAVVRTLDTLSSASAGEEGAVLKLSPQESQQWLRALNDLRLAIGSRLEIADEDDTDLLYRLPDEDPRKPMVMAYLWLGGLQESLVATLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2J8</accession>
    <name>Q9S2J8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2005</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35750">
        <property type="entry name" value="T35750"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626266.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028089.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2005"/>
    <dbReference type="GeneID" id="1097439"/>
    <dbReference type="KEGG" id="sco:SCO2005"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2034"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_13_2_11"/>
    <dbReference type="InParanoid" id="Q9S2J8"/>
    <dbReference type="OMA" id="TSCRLTC"/>
    <dbReference type="PhylomeDB" id="Q9S2J8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="79"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="18533" checksum="2EAF562A8B62CE0D" modified="2000-05-01" version="1">MRPAGGHADGSTKRSRPMGERQQVQFPQEVIDEYAALGVDLPALFSAGHLGTRMGVQIVEASADRVVGTMPVEGNTQPYGLLHGGASAVLAETLGSVGSMLHGGAAKIAVGVDLNCTHHRGVRSGLVTGVATPVHRGRSTATYEVVISDEQDRRVCTARLTCLLRDVNPGDGVRAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2K3</accession>
    <name>Q9S2K3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP-binding RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2000</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35745">
        <property type="entry name" value="T35745"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626261.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028086.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2000"/>
    <dbReference type="GeneID" id="1097434"/>
    <dbReference type="KEGG" id="sco:SCO2000"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2028"/>
    <dbReference type="eggNOG" id="COG1643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_6_11"/>
    <dbReference type="InParanoid" id="Q9S2K3"/>
    <dbReference type="OMA" id="DLRILVM"/>
    <dbReference type="PhylomeDB" id="Q9S2K3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB52056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="998" mass="105837" checksum="66DDB7D6B6525E35" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2M0</accession>
    <name>Q9S2M0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2124</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35505">
        <property type="entry name" value="T35505"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626381.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976691.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2124"/>
    <dbReference type="GeneID" id="1097558"/>
    <dbReference type="KEGG" id="sco:SCO2124"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2159"/>
    <dbReference type="eggNOG" id="ENOG5033FW7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092812_0_0_11"/>
    <dbReference type="OMA" id="MTWWLTT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="205" mass="22061" checksum="E123A3387701D35E" modified="2000-05-01" version="1">MAEHDSDREDREERDLEREHREGRERAADGGPEAQDAPFDEDAAWASIVAGYGEEPPDPPGAKPFKSVEDLALLEPEVNDEKPSADRPSSDRPLGSSVAFAPGVGPRDHAPAEPSDDDFDADDEGHFVPPEPPPLPETDPTSKFAWLGVLGGPVLLLLAVVLGWDMTWWLTTLSIGGFLGGFATLVVRMRTGDEDDDDPGRGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2R9</accession>
    <name>Q9S2R9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2167</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35283">
        <property type="entry name" value="T35283"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626420.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976649.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2167"/>
    <dbReference type="GeneID" id="1097600"/>
    <dbReference type="KEGG" id="sco:SCO2167"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2204"/>
    <dbReference type="eggNOG" id="ENOG5032YW2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186753_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2R9"/>
    <dbReference type="OMA" id="MIVRIMG"/>
    <dbReference type="PhylomeDB" id="Q9S2R9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB51251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="9994" checksum="294CF1C16ADFD979" modified="2000-05-01" version="1">MIVRIMGEGQLTLADGRLGELNKLDDELLAEMENGDGPGFRATLQALLAKVRELGEPLPDDTLEPSDLILPSPDATLEEVQELLSDDGLIPGGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8K4</accession>
    <name>RS182_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR2</name>
        <name type="ordered locus">SCO3425</name>
        <name type="ORF">SCE9.32c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36351">
        <property type="entry name" value="T36351"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627631.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028969.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8K4"/>
    <dbReference type="SMR" id="Q9X8K4"/>
    <dbReference type="STRING" id="100226.SCO3425"/>
    <dbReference type="GeneID" id="1098862"/>
    <dbReference type="KEGG" id="sco:SCO3425"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3487"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X8K4"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="PhylomeDB" id="Q9X8K4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000111237" description="30S ribosomal protein S18 2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="79" mass="9324" checksum="FF40165F0A62BE6A" modified="1999-11-01" version="1">MPRPRKADRTPARQRPNPLDRDGVTYVDYKDTELLRKFVSDRGKIRSRRVTRVTSQQQRQLARAIKNAREMALLPYGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8L2</accession>
    <name>Q9X8L2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3433</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36359">
        <property type="entry name" value="T36359"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627639.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028974.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3433"/>
    <dbReference type="GeneID" id="1098870"/>
    <dbReference type="KEGG" id="sco:SCO3433"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3495"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083296_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8L2"/>
    <dbReference type="OMA" id="TEIGKCM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="95"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27321" checksum="4194936A29FA73F9" modified="1999-11-01" version="1">MTTNPSITSSVRLDELITAIKKVHPEPLEQLQDAVIAGEHLGEVADHLIGHFVDQARRSGASWTDIGKSMGVTRQAAQKRFVTKESADLDAGQGFSRYTPRARNVVMTAHNAAKTAGNAEGLPEHLVLGLVTERESLSAKAIAAQGVTLDAIHEAATAALPPAAAEVPELVPYGPAAKKVLELTFREALRLGHNYIGTEHILLALLEHEHGEGVLSGLGLDKEATERYVVDAVAEFIHLTEKAEKAGASREGGAAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8P5</accession>
    <name>Q9X8P5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3628</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36518">
        <property type="entry name" value="T36518"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627822.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029126.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3628"/>
    <dbReference type="GeneID" id="1099064"/>
    <dbReference type="KEGG" id="sco:SCO3628"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3687"/>
    <dbReference type="eggNOG" id="ENOG5032SM3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111512_2_0_11"/>
    <dbReference type="OMA" id="WTFTTYG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB42015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="17516" checksum="E8CBB56A5D8D5FC0" modified="1999-11-01" version="1">MRKPTTRTWIWLAAAVVVVTGGAFYVDGHRVSAAPHAGDPKCDEIVSRLPDDIPGASRDWALGDGVASWGGQKAVFRCGAEELQPNVNLCVTADGVDWVLDEARLKRDGVSVLRTYGRSPAVEFTYSGPREEVGGILTALDPAVKWIPQERKCIGLDDAATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X914</accession>
    <name>Q9X914_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3548</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-6406843">
            <id>Q9X914</id>
        </interactant>
        <interactant intactId="EBI-6406852">
            <id>Q9WVX8</id>
            <label>rsbV</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>6</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-6406843">
            <id>Q9X914</id>
        </interactant>
        <interactant intactId="EBI-6406843">
            <id>Q9X914</id>
            <label>SCO3548</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36669">
        <property type="entry name" value="T36669"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627746.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975387.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q9X914">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3548"/>
    <dbReference type="GeneID" id="1098984"/>
    <dbReference type="KEGG" id="sco:SCO3548"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3604"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119460_0_0_11"/>
    <dbReference type="OMA" id="GVIRMSW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="IntAct"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="143" mass="14958" checksum="09CB8FB4E0E97197" modified="1999-11-01" version="1">MATVELRFSALPEHVRTARLVAAAVARRAGVDEAVLDEVRLAVGEACTRAVGLHQHVGITAPVKVSLIEEEKQFSIEVGDEAPHAVPGVKTSGDAVDELEAEEDEMGLAVISGLVDDVEVSAGEDGGLIRMTWPTASAVLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9T5</accession>
    <name>Q9X9T5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3933</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37186">
        <property type="entry name" value="T37186"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029320.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3933"/>
    <dbReference type="GeneID" id="1099369"/>
    <dbReference type="KEGG" id="sco:SCO3933"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4005"/>
    <dbReference type="eggNOG" id="ENOG5034A3J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159294_0_0_11"/>
    <dbReference type="OMA" id="LEAFAWN"/>
    <dbReference type="PhylomeDB" id="Q9X9T5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB46971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="116" mass="12228" checksum="4B6986EB74C7E6CD" modified="1999-11-01" version="1">MQSIPVDTTRLGVLRCAIAPEAKLSNPATQEVKKDRDGNPVYTVAVTVRQDRRRISVIEIAVSGEPKGIQEGQIVKVTGLTAFAWAMGDRHGISFRADAITPISGAATAQGKGGDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9U0</accession>
    <name>THIC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="1">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="1">HMP-P synthase</shortName>
            <shortName evidence="1">HMP-phosphate synthase</shortName>
            <shortName evidence="1">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiC</name>
        <name type="ordered locus">SCO3928</name>
        <name type="ORF">SCQ11.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="1"/>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37181">
        <property type="entry name" value="T37181"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628113.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029315.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X9U0"/>
    <dbReference type="SMR" id="Q9X9U0"/>
    <dbReference type="STRING" id="100226.SCO3928"/>
    <dbReference type="GeneID" id="1099364"/>
    <dbReference type="KEGG" id="sco:SCO3928"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4002"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_1_11"/>
    <dbReference type="InParanoid" id="Q9X9U0"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="PhylomeDB" id="Q9X9U0"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025747">
        <property type="entry name" value="ThiC-associated_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13667">
        <property type="entry name" value="ThiC-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000152839" description="Phosphomethylpyrimidine synthase">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="327"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="612" mass="67372" checksum="290BF2454200CF68" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9U2</accession>
    <name>Q9X9U2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3926</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37179">
        <property type="entry name" value="T37179"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628111.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029313.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3926"/>
    <dbReference type="DNASU" id="1099362"/>
    <dbReference type="GeneID" id="1099362"/>
    <dbReference type="KEGG" id="sco:SCO3926"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4000"/>
    <dbReference type="eggNOG" id="ENOG5033V9Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126599_0_1_11"/>
    <dbReference type="OMA" id="VTWAFGR"/>
    <dbReference type="PhylomeDB" id="Q9X9U2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB46964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="14920" checksum="4B67C1F1E0BECC88" modified="1999-11-01" version="1">MMSFLVSEELSFRIPVELRYETRDPYAVRLTFHLPGDAPVTWAFGRELLVDGVGRPCGDGDVRIAPVEPEPLAEVLIRLQVGSDQALFRSSAAPLVAFLDRTDKLVPLGQEGALADFDSHLDEALDRILAEEQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA03</accession>
    <name>Q9XA03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3861</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB45228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36730">
        <property type="entry name" value="T36730"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628049.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029277.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3861"/>
    <dbReference type="GeneID" id="1099297"/>
    <dbReference type="KEGG" id="sco:SCO3861"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3932"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631534_0_0_11"/>
    <dbReference type="OMA" id="AGWYYLS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177036" evidence="3">
        <location>
            <begin position="21"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="45246" checksum="7C0805D1E2923EE0" modified="1999-11-01" version="1">MGRWCTARRSAATGRVAVTAAVLAAVLATTAALPGATSLAPGLAAGSAGSAAGYDFADDAVRIAGARATAGAEPLAAGATYRSSLPRNGTLYYRLELDAASDAYVSVTAVPGADGEVTAVDGIRVSVQDAEGGSCSVQSATFGAARSPRPVTARGMREIDPAAHRCQDPGTYYVGVERTRPQDSPPDDWDLELTVATEPRPRETGATKAPEAWDSASPEPLAGEPERRPGGNGFAHATLVGQGVWRDDIRPGETLYYKVPVDWGRQVYATAELAGSADASGYATGALRLALHNPVRGEVDDAAKGYTGRTTTVGLAPLPPVAYPNRYATGQAGALRFAGDYYVVIHLAAQVADDFGQGPFALTLRLRLGGSAGTGPGYAGESRPKGLFEVSAQDRVAAPAGGGADDRLAMKAVAVGGIGTGSLLLLGLAVWTTTARRRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA88</accession>
    <name>Q9XA88_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0837</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB48914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36450">
        <property type="entry name" value="T36450"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625137.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027380.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0837"/>
    <dbReference type="GeneID" id="1096260"/>
    <dbReference type="KEGG" id="sco:SCO0837"/>
    <dbReference type="HOGENOM" id="CLU_2467567_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB48914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="88" mass="9213" checksum="0CF8EF565242FD66" modified="1999-11-01" version="1">MASGGVAVGRPARAGPAVRAAPAAREQTQMPAPGVPGRVRITEQPVLQIRHGEQQQTQCGQQQDGNGDHARDPFHRGTTPGGCPDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAH7</accession>
    <name>Q9XAH7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6687</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB46975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35547">
        <property type="entry name" value="T35547"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630761.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031105.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6687"/>
    <dbReference type="GeneID" id="1102126"/>
    <dbReference type="KEGG" id="sco:SCO6687"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6792"/>
    <dbReference type="eggNOG" id="ENOG502ZAJJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004188_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAH7"/>
    <dbReference type="OMA" id="GTWWPQD"/>
    <dbReference type="PhylomeDB" id="Q9XAH7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB46975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1678" mass="181533" checksum="60E0C7D2D8564BB8" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI2</accession>
    <name>Q9XAI2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protei</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3620</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35388">
        <property type="entry name" value="T35388"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627815.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029121.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3620"/>
    <dbReference type="GeneID" id="1099056"/>
    <dbReference type="KEGG" id="sco:SCO3620"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3678"/>
    <dbReference type="eggNOG" id="ENOG5033CIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075314_0_0_11"/>
    <dbReference type="OMA" id="ELYRWVE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040688">
        <property type="entry name" value="SLATT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18183">
        <property type="entry name" value="SLATT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_2" evidence="3">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="26942" checksum="DB5168A02A4417EE" modified="1999-11-01" version="1">MGQPEMQPEGPPQRGRDGEGGAAGTRPGDLTGRTFPLGDWALPAERLDELYRWVERGALDTAAWYLADRVWKRRGAVLLRGGAAVGAAAGAALPLLDLSGAVGGVAPWGYLALLWAVACVAGDRYFGVTSGWMRDVATAQAVQRRLQALQFDWASESVREVLGPADGTASEAAERCLLVLRRFSEDVTELVRAETADWMVCFRPGPGPLGPHAAAAADGPRPDGAGTGATGRFPLPPQNGSRPNMPRQRPPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ8</accession>
    <name>Q9XAQ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NuoE, NADH dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4566</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34620">
        <property type="entry name" value="T34620"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628728.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974380.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4566"/>
    <dbReference type="GeneID" id="1100006"/>
    <dbReference type="KEGG" id="sco:SCO4566"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4638"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054537_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAQ8"/>
    <dbReference type="OMA" id="QVGVCTN"/>
    <dbReference type="PhylomeDB" id="Q9XAQ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB44527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="30635" checksum="CC20CE4A67152723" modified="1999-11-01" version="1">MTTSSSERGVSLGMPELPAPAYPDDVRARLETDAREIIARYPDSRSALLPLLHLVQSEEGHVTRTGMQFCADVLDLTTAEVTAVATFYTMYRRRPSGDYQVGVCTNTLCAVMGGDAIFESLQDHLGVGNGETTEDGKVTLEHIECNAACDFAPVVMVNWEFFDNQTPASVKALVDDLRAGRPVTPTRGAPLCTFKETARILAGFPDERDGAVAAGGSAGPASLAGLRLAKGEASAARVVHPRDGGPHDAPQDRAVHDPSPTEHLSSHDAPQDTSASDPSNPAGPTAEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XD95</accession>
    <accession>Q7AKJ3</accession>
    <name>Q9XD95_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4544</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="5470" last="5478">
            <title>WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Ainsa J.A."/>
                <person name="Ryding N.J."/>
                <person name="Hartley N."/>
                <person name="Findlay K.C."/>
                <person name="Bruton C.J."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="10986251"/>
            <dbReference type="DOI" id="10.1128/JB.182.19.5470-5478.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF106004">
        <property type="protein sequence ID" value="AAD42173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628707.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029722.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4544"/>
    <dbReference type="GeneID" id="1099984"/>
    <dbReference type="KEGG" id="sco:SCO4544"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4616"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_20_1_11"/>
    <dbReference type="OMA" id="TICRRTL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAD42173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="141" mass="15421" checksum="D533D5E05C4F275D" modified="1999-11-01" version="1">MPETEPFDPAAPWEYTLYIPNDLRAVTVCRRTLRLILTMHGLIRLVDTAELLATELVSNAVRHTKGPAALRVRWAAGVLRVGAWDADPGPPEPPGNLDALTEAEEGRGLALVRACADLWGWQPLARGGNRGKYVWCDLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z522</accession>
    <name>Q9Z522_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="4" type="ordered locus">SCO1943</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36016">
        <property type="entry name" value="T36016"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626207.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976875.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1943"/>
    <dbReference type="GeneID" id="1097377"/>
    <dbReference type="KEGG" id="sco:SCO1943"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1970"/>
    <dbReference type="eggNOG" id="ENOG5031GEE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134276_1_0_11"/>
    <dbReference type="OMA" id="CANGHET"/>
    <dbReference type="PhylomeDB" id="Q9Z522"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB38133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="111" mass="12066" checksum="0494E90BF0CEB611" modified="1999-05-01" version="1">MASGNAIRGSRVGAGPMGEAERGESAPRLRISFWCSNGHETQPSFASDAQVPETWDCPRCGFPAGQDRDNPPDPPRTEPYKTHLAYVRERRSDADGEAILAEALAKLRGEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z527</accession>
    <name>RBFA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">SCO5708</name>
        <name type="ORF">SC9F2.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35987">
        <property type="entry name" value="T35987"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629835.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973318.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z527"/>
    <dbReference type="SMR" id="Q9Z527"/>
    <dbReference type="STRING" id="100226.SCO5708"/>
    <dbReference type="PRIDE" id="Q9Z527"/>
    <dbReference type="GeneID" id="1101147"/>
    <dbReference type="KEGG" id="sco:SCO5708"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5797"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z527"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="PhylomeDB" id="Q9Z527"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000102743" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="160" mass="17390" checksum="E1C21C09EFCDCBF0" modified="1999-05-01" version="1">MADNARAKRLADLIREVVAQKLQRGIKDPRLGSHVTITDTRVTGDLREATVFYTVYGDDEERKAATAGLESAKGILRSEVGKAAGVKFTPTLTFVMDALPDTARNIEDLLDKARQSDEKVREASAGATYAGEADPYRKPDEDETDTEGAVEADETDDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z586</accession>
    <name>Q9Z586_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5493</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB37569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35809">
        <property type="entry name" value="T35809"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629628.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030277.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5493"/>
    <dbReference type="GeneID" id="1100933"/>
    <dbReference type="KEGG" id="sco:SCO5493"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5577"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065357_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z586"/>
    <dbReference type="OMA" id="DRPGRDT"/>
    <dbReference type="PhylomeDB" id="Q9Z586"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB37569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="331" mass="34990" checksum="E63CA4DB7B4FA32F" modified="1999-05-01" version="1">MNDTFAPATGIGSLPGHDAREAAKTATGSFEDFPFLPELPARGPGADMIGRTAGMLVELYARVEPSGWRLGDRPGRDTKRARAWLGEDLDALEEFTQGYEGPLKVQAVGPWTLAAALELRGGEAVLSDPGACRDLAASLAEGLRLHLAEVRRRVPGARVVLQLDEPSLTAVLRGRIRTASGYRTHRAVDRQVVEGSLREVAGVHDGGPVVVHSCAPDVPFALLRRAGVAGVSFDFSLLTERDDDAIGEAVEGGTRLFTGVVPGTDTALSDPAGSVRGVRTLWRRLGLRPELLAEAVTVTPACGLAGASPDYARRALAHCVRAARSLADNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5A7</accession>
    <name>Q9Z5A7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6195</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34849">
        <property type="entry name" value="T34849"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630298.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030731.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6195"/>
    <dbReference type="GeneID" id="1101636"/>
    <dbReference type="KEGG" id="sco:SCO6195"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6308"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_11"/>
    <dbReference type="InParanoid" id="Q9Z5A7"/>
    <dbReference type="OMA" id="HAWSNLF"/>
    <dbReference type="PhylomeDB" id="Q9Z5A7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015645">
        <property type="term" value="F:fatty acid ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="457"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB36603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="558" mass="61462" checksum="C7ED7B6AADD53C74" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O50509</accession>
    <name>O50509_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35871">
        <property type="entry name" value="T35871"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629958.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030486.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5835"/>
    <dbReference type="GeneID" id="1101277"/>
    <dbReference type="KEGG" id="sco:SCO5835"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5932"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_1_1_11"/>
    <dbReference type="InParanoid" id="O50509"/>
    <dbReference type="OMA" id="MWGVLRY"/>
    <dbReference type="PhylomeDB" id="O50509"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="232"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA15792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="362" mass="38524" checksum="2B1F7CF65EF87104" modified="1998-06-01" version="1">MGQRSTPQQIPVVVLAGFLGSGKTTLLNHLLHRSGGSRIGAVVNDFGSIEIDAMAVAGALGDSTVSLGNGCLCCAVDASELDGYLARLARPEAGIDVIVIEASGLAEPQELVRMLLASEQPGIVYGGLVEVVDAAEFDDTRARHPEIDRHLALADLVVVNKTDRATDAERVLGLVHSLVGGAAVVPATYGRIDPEFLYDCRPGEERVGQLSFDDLHDHSEGGAHADHLHAAYDTLSFVSGLPLDPRRLMRFLDSRPKGLYRIKGYVDFGPYDTRNRYAVHAVGRFLRFYPEPWTPAGAAGGSGAPETGRTQLVLIGSGIDAAALGEELDACRRDADAPPADEHGMWGVLRYVADGEEPPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O69858</accession>
    <name>O69858_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6028</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34708">
        <property type="entry name" value="T34708"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630139.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030604.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6028"/>
    <dbReference type="GeneID" id="1101469"/>
    <dbReference type="KEGG" id="sco:SCO6028"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6128"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042387_3_0_11"/>
    <dbReference type="InParanoid" id="O69858"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="PhylomeDB" id="O69858"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="214"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="394" mass="42461" checksum="DEF10258BFF26B7B" modified="1998-08-01" version="1">MLEPREGIPPVIADADALAEVTAAFAAGSGPVAVDAERASGYRYGQRAYLVQLRRAGAGSALIDPVACPDLSGLGAAIADAEWVLHAATQDLPCLREIGMVPTRIFDTELAGRLAGFPRVGLGAMVENVLGFVLEKGHSAVDWSTRPLPEPWLRYAALDVELLVDLRDALEKELDRQGKLEWARQEFDAIASAPPAEPRKDPWRRTSGMHKVRRRRQLAVVRELWQARDRIAQRRDVSPGKVLGDAAIVEAALALPPNAHALAALNGFGRVNRRQLEQWQLSVDRARALSESQLPQPGQPVTGPPPPRAWADKDPAAAARLTAARAAVTALAERLSMPQENLITPDTVRRVCWEPPATVDAESVGAALAGHGARPWQVEQVTPVLVAALSREAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O86568</accession>
    <name>O86568_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5473</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAA20176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34753">
        <property type="entry name" value="T34753"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629609.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030270.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5473"/>
    <dbReference type="GeneID" id="1100913"/>
    <dbReference type="KEGG" id="sco:SCO5473"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5557"/>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084942_0_0_11"/>
    <dbReference type="OMA" id="VHDCGTQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24353" checksum="37B7853003CA90C0" modified="1998-11-01" version="1">MNRTTAYATTSGLALPKQPAAPAPEACAPLTAPVVRDLRDRDGRSPHALLFGPRDLVVITGLPGSGKSTLMRRTVRGGRIDSQDTRDRWDRRVPRLLPYTLYRPFVRLAHYAGLRRALRSGEGVVVHDCGTQAWVRGWLAREARRRHGTLHLLLLDVAPGEALAGQRERGRGVSRYAFLRHRAANSRLLRAVTEGTLPAGCSSAVVLDRAAADTLRRIAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O86590</accession>
    <name>O86590_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6225</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37223">
        <property type="entry name" value="T37223"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630326.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030748.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6225"/>
    <dbReference type="GeneID" id="1101666"/>
    <dbReference type="KEGG" id="sco:SCO6225"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6339"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647068_0_0_11"/>
    <dbReference type="InParanoid" id="O86590"/>
    <dbReference type="OMA" id="GWTPIGP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174873" evidence="2">
        <location>
            <begin position="29"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="40"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="421" mass="44175" checksum="F7749DBD5E4F5C41" modified="1998-11-01" version="1">MITRTRLAAGACALLAALAAGMAFPAGASAGEPTGEDAPKVDLVLDVSGSMRTRDIDGGTRMAAAKQAFNEVLDATPEEVRLGIRTLGADYPGDDRKTGCKDTAQLYPVGPLDRTEAKTAVATLSPTGWTPIGPALLKAADDLDGGDGSKRIVLISDGEDTCAPLDPCEVAREIAAKGIGLTIDTLGLVPNTKMRQQLSCIAEATGGTYTSVEHTDELTDKVNQLVDRAADPVVTPVATEGADACAKAPTLKSGLYTDREEFGQQRWYRVDVEPGQELRASVSVGADRAVNPSYGVLLRAVTVHGREIVRGEAAGNGRTDVLSTGLRYPKAKSDEDDAPAEAVCLQVTNSFSVASGVKTSPGLPLELTVDVVDGPGDSDDVAAFGLGRGWWLLGLLVLVGFVAGLLWGWLSRWRFAIWRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O86787</accession>
    <name>O86787_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4746</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35575">
        <property type="entry name" value="T35575"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628904.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029836.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4746"/>
    <dbReference type="ESTHER" id="strco-SC6G4.24">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1100187"/>
    <dbReference type="KEGG" id="sco:SCO4746"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4818"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_6_2_11"/>
    <dbReference type="InParanoid" id="O86787"/>
    <dbReference type="OMA" id="FSHGYCL"/>
    <dbReference type="PhylomeDB" id="O86787"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="420" mass="44028" checksum="EE05B3FD930505E1" modified="1998-11-01" version="1">MHVSESNAEAVAAAVASATEAATEAAAGGWRRATGIAGVAIGVVAAGAAAGVAIERLTVGRGMRQKARLALDSTGPYGGLRGTPGKAYAEDGTELYYEVDDLDPEAGADPAPRRRRLFGRKAPAPVTVVFSHGYCLNQDSWHFQRAALRGVVRSVYWDQRSHGRSGRGVAQTRDDRPVSIEELGRDLKAVIDAAAPEGPIVLVGHSMGGMTVMALADAFPDLVRERVVGVALVGTSSGRLGEVNFGLPVAGVNAVRRVLPGVLRALGQRAELVERGRRATADLFAGIIKRYSFASRDVDPAVARFAERMIESTPIDVVAEYYPAFNDHDKTEALAHFAGLPVLVLAGVRDLVTPSEHSEAIADLLPDAELVLVPDAGHLVMLEHPELVTDRLADLLARAGAVPAATTVDGYGSTSSTGPG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>P0A3Z3</accession>
    <accession>Q60394</accession>
    <name>AMPP2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Xaa-Pro aminopeptidase 2</fullName>
            <ecNumber>3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Aminoacylproline aminopeptidase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Aminopeptidase P II</fullName>
            <shortName>APP</shortName>
            <shortName>PEPP II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>X-Pro aminopeptidase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Xaa-Pro aminopeptidase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pepP2</name>
        <name type="ordered locus">SCO1352</name>
        <name type="ORF">2SCG61.34c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625637.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027739.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A3Z3"/>
    <dbReference type="SMR" id="P0A3Z3"/>
    <dbReference type="STRING" id="100226.SCO1352"/>
    <dbReference type="MEROPS" id="M24.033"/>
    <dbReference type="GeneID" id="1096775"/>
    <dbReference type="KEGG" id="sco:SCO1352"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1360"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_0_11"/>
    <dbReference type="InParanoid" id="P0A3Z3"/>
    <dbReference type="OMA" id="YRRWTLH"/>
    <dbReference type="PhylomeDB" id="P0A3Z3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000185080" description="Xaa-Pro aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="470" mass="51925" checksum="0D3D33CE256523C2" modified="2005-03-15" version="1">MSNRRKNSLYPTLSAELSALMRTGWADTERHDLAPAEQAPYAALRRAALSARFPGERLVVPSGNLKVRSNDDTYPFRSYSGYVHMTGDQARDGALVLEPRPDGGHDAYCYQLPRDSRDDDEFWTGAHAELWTGRRRSLAESERVLGLPCRDVRTAAADLAAVSEVRTRIVRGIDPALEAAVTTDEERDAELEDALSDLRLVKDAWELGELRKAVDSTVRGFTDVVGELSRAVASSERWLEGTFFRRARLEGNAVGYGTICAAGEHATIMHWTDNDGPVRPGDLLLLDAGVETRSLYTADVTRTLPISGTFTPLQREVYDAVYEAQEAGIATVKPGAAYRDFHEAAQRHLAARLVEWGFIEGPAERAYELGLQRRFTMAGTGHMLGLDVHDCARARTEEYVEGVLEPGMCLTVEPGLYFQADDLTVPEEWRGIGVRIEDDLVVTEDGHENLSAGLPRSADEVEAWMARFAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>P0A4G6</accession>
    <accession>P55021</accession>
    <accession>P95725</accession>
    <accession>Q54396</accession>
    <name>SECA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">SCO3005</name>
        <name type="ORF">SCE33.07c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brans A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="X79813">
        <property type="protein sequence ID" value="CAA56209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42056">
        <property type="entry name" value="T42056"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627227.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975807.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A4G6"/>
    <dbReference type="SMR" id="P0A4G6"/>
    <dbReference type="STRING" id="100226.SCO3005"/>
    <dbReference type="PRIDE" id="P0A4G6"/>
    <dbReference type="GeneID" id="1098438"/>
    <dbReference type="KEGG" id="sco:SCO3005"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3064"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_11"/>
    <dbReference type="InParanoid" id="P0A4G6"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="PhylomeDB" id="P0A4G6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031522">
        <property type="term" value="C:cell envelope Sec protein transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015462">
        <property type="term" value="F:ABC-type protein transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000109615" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="947" mass="106456" checksum="ECE618B7890AEC51" modified="2005-03-15" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>P56833</accession>
    <name>MRAY_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="synonym">murX</name>
        <name type="ordered locus">SCO2087</name>
        <name type="ORF">SC4A10.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34957">
        <property type="entry name" value="T34957"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626346.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976728.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P56833"/>
    <dbReference type="SMR" id="P56833"/>
    <dbReference type="STRING" id="100226.SCO2087"/>
    <dbReference type="GeneID" id="1097521"/>
    <dbReference type="KEGG" id="sco:SCO2087"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2120"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_11"/>
    <dbReference type="InParanoid" id="P56833"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="PhylomeDB" id="P56833"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000108902" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="363" mass="38893" checksum="526A8016B7F3EC29" modified="2000-05-30" version="1">MKQILFAGVIGLFLTLVGTPLLIKLLARKGYGQYIRDDGPREHASKRGTPTMGGIAFILATVAAYFLAKGITSYLDPDIDAGPTFSGLLVLGLMVGMGLVGFLDDYIKIVKRRSLGLRARAKMIGQLTVGIAFAVLSLQFADNRGNTPASTKLSFITDFGWTIGPVLFVVWALFMILAMSNGVNLTDGLDGLATGASVLVFGAYTFIGVWQFQESCANALTLTNPGACYEVRDPLDLAVVASALMGSCLGFLWWNTSPAKIFMGDTGSLALGGVLAGLAICSRTELLMAILGGLFVLITMSVVIQVGSFRLTGKRVFRMAPLQHHFELKGWSEVLVVVRFWIIQGICVIVGLGLFYAGWATDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKC8</accession>
    <name>Q7AKC8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7362</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631415.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031610.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7362"/>
    <dbReference type="GeneID" id="1102800"/>
    <dbReference type="KEGG" id="sco:SCO7362"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7465"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_11"/>
    <dbReference type="InParanoid" id="Q7AKC8"/>
    <dbReference type="OMA" id="GPWGCGT"/>
    <dbReference type="PhylomeDB" id="Q7AKC8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="346" mass="35430" checksum="0E595884971162D8" modified="2012-05-16" version="1">MKALQYRTIGAPPEVVTVPDPEPGPGQVLLKVTAAGVCHSDIAVMSWPAEGFPYELPLTLGHEGVGTVAALGAGVTGLAEGDAVAVYGPWGCGTCAKCAEGKENYCLRADELGIRPPGLGRPGSMAEYLLIDDPRHLVPLDGLDPVAAVPLTDAGLTPYHAIKRSLPKLVPGSTAVVIGTGGLGHVAIQLLRALTSARVVALDVSEEKLRLARAVGAHEAVLSDAKAADAVREITGGLGAEAVFDFVGVAPTVQTAGAVAAVEGDVTLVGIGGGSLPVGFGMLPFEVSVNAPYWGSRSELTEVLNLARSGAVSVHTETYSLDDAPLAYERLHEGRVNGRAVILPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKD1</accession>
    <name>Q7AKD1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase secondary sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO7341</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631395.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031598.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7341"/>
    <dbReference type="GeneID" id="1102779"/>
    <dbReference type="KEGG" id="sco:SCO7341"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7445"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_11"/>
    <dbReference type="InParanoid" id="Q7AKD1"/>
    <dbReference type="OMA" id="FIRDKTW"/>
    <dbReference type="PhylomeDB" id="Q7AKD1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB92887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="29423" checksum="667B4525422663EB" modified="2012-05-16" version="1">MRVAGRTQPHPHDDAPDTAAAFERLAGLPEGPERKALRDDLIRVWLPMAERIAVRFRGRGENLEDLYQVAALGLVKAVDHYDPERGHAFEAYAVPTVTGEIKRHFRDHMWTLHVPRRIQDLRNRVRKSAKELAQTTPGRAPTVEEIAEHAQLTTAEVRTGMEALECFSALSLEAEMPGTDGYALGDALGGPDPAFDAVVDRVAVRPCLEALPERERTILYLRFFGGMTQSRIAQQLGISQMHVSRLLTGCFDRIREEILAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJL8</accession>
    <name>Q8CJL8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphonopyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6824</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAD55389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031211.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6824"/>
    <dbReference type="GeneID" id="1102263"/>
    <dbReference type="KEGG" id="sco:SCO6824"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6933"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042853_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJL8"/>
    <dbReference type="OMA" id="PILASWR"/>
    <dbReference type="PhylomeDB" id="Q8CJL8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050545">
        <property type="term" value="F:sulfopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019295">
        <property type="term" value="P:coenzyme M biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="217"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="367" mass="38134" checksum="2B2BF826055F207D" modified="2003-03-01" version="1">MITAQEFCDLLADGGFTFASGVPCSHFGGPIAHLSTEPGRYVPAPNEGSALAVAAGAALGGQRAYVMLQNSGLGNLINPLTSLVMTYQLPILTFASLRGWPDPATDEPQHAVMGPATHGLLDSVDTPHHTLYAQDGVEEFAAVLEKAEKDLAEQRAPFVLVERGAIGKAAAANSPHTEGLPAAEAIRLVTSAAPQAAVVATTGFTGRDTFAVADTPSTFYMQGSMGHASSIGLGVALTQPERTVVVLDGDGALLMHLGALSMIGSEAPANLIHVVLDNRVHESTGGQATTSATTSFPEMAKAAGYADAVVCDREEDVRAAMLRAQAAPGPHLICIKTLPRTGAIPPRATNALSTLDIRDRFQNDLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJS1</accession>
    <name>Q8CJS1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5138</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD55224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733656.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030078.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5138"/>
    <dbReference type="GeneID" id="1100579"/>
    <dbReference type="KEGG" id="sco:SCO5138"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5221"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068874_0_0_11"/>
    <dbReference type="InParanoid" id="Q8CJS1"/>
    <dbReference type="OMA" id="AHWAVAN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="33830" checksum="49A60A2A1E0B4C37" modified="2003-03-01" version="1">MLQPSPPRKRRGRLARSGAASMVLLAVAGYLAVQYVTGGAFAPGCKVAGGKGGRTTYEFTPEQAVNAATITAVGTARKLPDRAVTIALAAALQESALRNLDHGDKDSLGLFQQRPSQGWGKPEEIMDPAYSAGLFYDHLVEVPGYLDLPLTDAAQRVQRSAFPDAYAKHEPDAELLAAALTGRSAATLTCVGRPGATPEKGPDAVRAALVRDFGHDVLRPAGAEVGGDAASRRPATGSDERTVTLPVTGSTGSGPAREHVRRGWQLAHWAVANASSLHIQRVTYAGREWTAGNTDSKWYPTGTEGAKGAERAAEAVRITSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJU3</accession>
    <name>Q8CJU3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4228</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAD55476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733631.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974747.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4228"/>
    <dbReference type="GeneID" id="1099668"/>
    <dbReference type="KEGG" id="sco:SCO4228"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4290"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_1_0_11"/>
    <dbReference type="InParanoid" id="Q8CJU3"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="PhylomeDB" id="Q8CJU3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="229" mass="25457" checksum="BF7E0AE52BE31CF6" modified="2003-03-01" version="1">MRDAYHEELDSIGDGLVEMARLVGSAIGRATTAILDSDLKLAEAVIEADQKVDNLQHELEARAITLLARQQPVATDLRIVVTSLRMSADLERSGDLAQHVAKLARLRYPERAVPHDLHATILEMGQLAQRLMAKAAEVIITKDVDLALQLEQDDDAMDLLHRTLFQHLMDDRWKHGIETAVDVTLLGRYYERFADHAVSVAKRVVYLVTGEHADDLQADIQPATQVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK40</accession>
    <name>Q8CK40_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1021</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAD55452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733520.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1021"/>
    <dbReference type="GeneID" id="1096444"/>
    <dbReference type="KEGG" id="sco:SCO1021"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1016"/>
    <dbReference type="eggNOG" id="ENOG50342JH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131560_0_0_11"/>
    <dbReference type="OMA" id="HAPAPYI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="149" mass="15770" checksum="10D6B90DCB55F914" modified="2003-03-01" version="1">MAMTSPRSTYGGGYYSASFPDTPIYDSLVAERGTPQIAPIRVPAAYDMPSSSHLPALPSALPALPAGPSQPSYGYPQQAPQPAPLQQAPAAYIPHQATAPRGYPGPQQPQQPRPGAPGPAGYEAMRPAAPRPAPAPYQDPYNQQQYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IV6</accession>
    <name>Q93IV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1314</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625600.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977515.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1314"/>
    <dbReference type="GeneID" id="1096737"/>
    <dbReference type="KEGG" id="sco:SCO1314"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1317"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_4_1_11"/>
    <dbReference type="InParanoid" id="Q93IV6"/>
    <dbReference type="OMA" id="GCWIGTG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="267" mass="28347" checksum="5167DE0AB664CAD3" modified="2001-12-01" version="1">MPHRKNTFSSWRSRLAQKAVHAGWAWVQRTGSVTAAHPGRFRFGALGTGTRLAFPLGTVFGEPWIQVGAHCIIGEQVTLTAGLMPDLDLGPEPILRIGDGVVLGRGSHVIADTTVTIGSDCYFGPYVYVTSTNHSYDDPHQPIGKQWPRMDPVEIGPGCWIGTGAVILPGARIGRNVVVAAGAVVRGAVPDHAVVAGAPARVVRRWTPAEGWQPPLRTPAPVPIPDGITPGQLRELSKLDDEAVARLAELDDPERAAGRLAEPAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J21</accession>
    <name>Q93J21_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3986</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628169.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029358.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q93J21"/>
    <dbReference type="STRING" id="100226.SCO3986"/>
    <dbReference type="GeneID" id="1099422"/>
    <dbReference type="KEGG" id="sco:SCO3986"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_8_1_11"/>
    <dbReference type="OMA" id="DIYIDRE"/>
    <dbReference type="PhylomeDB" id="Q93J21"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="26537" checksum="731CDDB7A9CF8ED3" modified="2001-12-01" version="1">MTSRRLIIADDLRRQITTGRIGPGDRLPSESALADRYKVSTATLRSALAVLQGEGLVEKIHGKGNFVRRTKRKITYVGGWGTLDPRTATDVDLRVTVRTTALPARGHLTALLKVDDGSPLTEFLRLSYEGESPHSLARVYVPRDLAPTTALKDRPSRAWAEASFSVSDPPPAEIHETVSARLPTPDEASTLRINTALAVLAITRVAADNTGRVVEAALLVFPGDRVDAVFSTHHVIEERQVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J39</accession>
    <name>Q93J39_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3967</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628150.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974977.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3967"/>
    <dbReference type="GeneID" id="1099403"/>
    <dbReference type="KEGG" id="sco:SCO3967"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4039"/>
    <dbReference type="eggNOG" id="COG4549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087540_0_0_11"/>
    <dbReference type="InParanoid" id="Q93J39"/>
    <dbReference type="OMA" id="NKEVVRW"/>
    <dbReference type="PhylomeDB" id="Q93J39"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176570" evidence="3">
        <location>
            <begin position="36"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC44691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="25843" checksum="6C3FCA3A8FB0DADB" modified="2001-12-01" version="1">MKASRIAAVGAVSGIAVLALSAPAFAHVSVQPEGAAAKGGYAVVDFKVPNERDNASTTKLEVNFPTDHPLASVMPQPVPGWKAEVTKAKPAKPLESHGKQITEVVTKVTWTADGKGVEPGYFQKFPVSIGALPEDADQLVFKAIQTYSNKEVVRWIEVPQEGQEEPETPAPVLKLSAAEDDAHGASGSSDAKAEDTGADAQNTAADASSSDSGSGDGSDTTARVLGIVGIVVGAAGVAYGVLAGRRRNSGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J40</accession>
    <name>Q93J40_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3966</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628149.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974978.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="PDBsum" id="4BPY"/>
    <dbReference type="SMR" id="Q93J40"/>
    <dbReference type="STRING" id="100226.SCO3966"/>
    <dbReference type="GeneID" id="1099402"/>
    <dbReference type="KEGG" id="sco:SCO3966"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_3_2_11"/>
    <dbReference type="InParanoid" id="Q93J40"/>
    <dbReference type="OMA" id="CPLTMNN"/>
    <dbReference type="PhylomeDB" id="Q93J40"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176571" evidence="3">
        <location>
            <begin position="27"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="47"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC44690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="23148" checksum="BB8ABBF5B0E1687A" modified="2001-12-01" version="1">MRKKTFATAALLAAACLTLSACGSGADSDKPVTVVSEDNSQQAATVLDKPFEKPDLVLTDTQGKKYDLREQTAGKPTLIYFGYTHCPDVCPLTMNNIAVAKKQLSQAEQDKLRVVFVSTDPERDTPAALGKWLKGIDPQIVGLTGEFDTIQAGARTLGISIDPPTKDKDGKIVSTHGTQVVAFSPKSDAGYVLYGEDATVDDYTKDLPKLIKGENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J47</accession>
    <name>Q93J47_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3056</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC44521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627277.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975755.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3056"/>
    <dbReference type="GeneID" id="1098489"/>
    <dbReference type="KEGG" id="sco:SCO3056"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3116"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_2_1_11"/>
    <dbReference type="OMA" id="FCLCRIE"/>
    <dbReference type="PhylomeDB" id="Q93J47"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="130" mass="14443" checksum="EBFFE99F0B4AEAD5" modified="2001-12-01" version="1">MAPAARFRSVVVDCPDPRELARFYAAVGGGTPDEADPDWVVLQVPGGPRLSFQRAPDLTPPEWPRSDRNAQQFHLDFDGGATWAEMDAAHDRVLALGARPLDLEDREDKDFMVYADPAGHPFCLCRIEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JE7</accession>
    <name>Q93JE7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative bifunctional hydroxylase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5980</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630096.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030579.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5980"/>
    <dbReference type="GeneID" id="1101422"/>
    <dbReference type="KEGG" id="sco:SCO5980"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6079"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_10_0_11"/>
    <dbReference type="InParanoid" id="Q93JE7"/>
    <dbReference type="OMA" id="PMFTPFR"/>
    <dbReference type="PhylomeDB" id="Q93JE7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="44"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="424"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="801" mass="87947" checksum="6D5462BFE94603C9" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-11" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF1</accession>
    <name>OTC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="2">OTCase</shortName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argF</name>
        <name type="synonym">arcB</name>
        <name type="ordered locus">SCO5976</name>
        <name type="ORF">SCBAC16H6.11</name>
        <name type="ORF">STBAC16H6.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630092.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030578.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93JF1"/>
    <dbReference type="SMR" id="Q93JF1"/>
    <dbReference type="STRING" id="100226.SCO5976"/>
    <dbReference type="GeneID" id="1101418"/>
    <dbReference type="KEGG" id="sco:SCO5976"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6075"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_1_11"/>
    <dbReference type="InParanoid" id="Q93JF1"/>
    <dbReference type="OMA" id="VYVKNWS"/>
    <dbReference type="PhylomeDB" id="Q93JF1"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000113031" description="Ornithine carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <sequence length="335" mass="36702" checksum="6FAFC3FBC876D337" modified="2001-12-01" version="1">MATVPTALAGRHFLKELDFTEEEFRGLIELAAELKAAKRAGTETRYLQGRNIALIFEKTSTRTRCAFEVAAADQGASTTYLDPAGSQIGHKESVKDTARVLGRMFDGIEYRGDSQTKVEELAAFAGVPVYNGLTDDWHPTQMLADVLTMTEHSDRPLREITFAYLGDARFNMGNSYLVTGALLGMDVRIVAPKSYWPAQEVVDRAHRLAAASGARITLTEDVAEGVRGAGFVVTDVWVSMGEPKEVWAERIKALAPYAVTMDVLRATGNPDVRFLHCLPAFHDLGTKVGQEIFEAHGLDSLEVTDEVFESAHSVVFDEAENRLHTIKAVLVATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RV0</accession>
    <name>Q93RV0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1876</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626143.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028024.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1876"/>
    <dbReference type="GeneID" id="1097310"/>
    <dbReference type="KEGG" id="sco:SCO1876"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1901"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_0_11"/>
    <dbReference type="InParanoid" id="Q93RV0"/>
    <dbReference type="OMA" id="ALWHRWD"/>
    <dbReference type="PhylomeDB" id="Q93RV0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC38811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="20866" checksum="F4BF9D34BE7BD1B6" modified="2001-12-01" version="1">MGTVVDDAAGEFRAFFERHYAELARLAHLLTGEPDAADDLAADALLALWHRWDRVRAADHPVAYARGVVANLARTRVRAAVRERRRVALFWSQREERTENPDVAGVVDVREALRRLPFRKRACVVLRHSFDLSEKDTALALGISVGTVKSQTSKGVAELQRLLGTRTAPRAPGQVRAAIAHSGETAGGAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q99PZ1</accession>
    <name>HOA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="1">HOA</shortName>
            <ecNumber evidence="1">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCP1.301</name>
    </gene>
    <gene>
        <name type="ordered locus">SCP1.53c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid">
        <name>SCP1</name>
    </geneLocation>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid>SCP1</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="1"/>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639628.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639910.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039354.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q99PZ1"/>
    <dbReference type="SMR" id="Q99PZ1"/>
    <dbReference type="GeneID" id="1095132"/>
    <dbReference type="GeneID" id="1095383"/>
    <dbReference type="KEGG" id="sco:SCP1.301"/>
    <dbReference type="KEGG" id="sco:SCP1.53c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8001"/>
    <dbReference type="HOGENOM" id="CLU_049173_0_0_11"/>
    <dbReference type="InParanoid" id="Q99PZ1"/>
    <dbReference type="OMA" id="CALMVRF"/>
    <dbReference type="PhylomeDB" id="Q99PZ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0614">Plasmid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000387924" description="4-hydroxy-2-oxovalerate aldolase">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <sequence length="338" mass="35318" checksum="ECC032842A1CF3BC" modified="2001-06-01" version="1">MNPPTVTVHDSTLRDGQHAVRHQLDADQIRAYAVAADTAGVPVLEVGHGNGIGASSRQVGLSKTDDATMLTTAREAMPHSRLATLMLPGWATSTDLRSAIRHGVDIVRVAAHCTEADVTERHLGVIRDLGAEAQGVLLMSHLAAPDELAAQCQRMVGYGAQAVCIFDSAGTYLPEDVTARITAITTAVDVPVAFHGHNNLGMAVANSLAAVRAGARVLDACARGFGAGAGNTQLEVLVAVLERYGHPTGIDLRLVAQAADLAERTLMPAPPTIDSTSLVSGLAGVFSGFKKPVLAAAQRAGVSPWDVFVELGRRRVLAGQEDLIPDAINTLTSMGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD47</accession>
    <name>Q9AD47_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.103</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639676.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039402.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095181"/>
    <dbReference type="KEGG" id="sco:SCP1.103"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8051"/>
    <dbReference type="HOGENOM" id="CLU_1488209_0_0_11"/>
    <dbReference type="OMA" id="CMLGAIR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="177" mass="18657" checksum="2360A4B29C8F50C7" modified="2001-06-01" version="1">MHQTRPAIDRTTPATPAPAELTFDERLAFINTAMTVRLDEAKVAYEVNTAHIPTEPVDLAAVVTGPVDIGPAPLADLYPTPVAALLQRAHHRLFTGGWCSGALVDEDGARCMLGAIRAEARGDSGLEADAAAVLLDVIRRRFGAVDSVPSFNDAHGSARVPLRMVDQAAGLADARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD58</accession>
    <name>Q9AD58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.92</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639665.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039391.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095170"/>
    <dbReference type="KEGG" id="sco:SCP1.92"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8040"/>
    <dbReference type="HOGENOM" id="CLU_086372_0_0_11"/>
    <dbReference type="OMA" id="PCRDGER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="202" mass="22417" checksum="D004C928067C8ADD" modified="2001-06-01" version="1">MSASPLERTARPRRSRTRSRTLNSRPALALSALKPHQYDLRRDCASLICPDCETWVPITGLRGTAPKVVPHDTGRTWKDAAVRCRLGSNRLVTVDVAVKQWQERLEDGHADTGHRRRTTVRRKPKAAVAPAVSQIAAQKQAPADDERGNDRPLWLLRKKQWAATESSVRDADTRRAQLPAGDAPLGAAPVPLKTLHPERRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADB8</accession>
    <name>Q9ADB8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629490.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030199.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5350"/>
    <dbReference type="GeneID" id="1100790"/>
    <dbReference type="KEGG" id="sco:SCO5350"/>
    <dbReference type="eggNOG" id="ENOG503243N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127697_0_0_11"/>
    <dbReference type="OMA" id="PRRRWII"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045729">
        <property type="entry name" value="DUF6083"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19561">
        <property type="entry name" value="DUF6083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="20454" checksum="F7C3F5048309A3C5" modified="2001-06-01" version="1">MDWGLRYISAACRRSLVVGCTCRVAFGLAGGLLPQRFRPVRALRLGCRTGDPHGMGLLEREPRRLSGGQSRCPDCGLLQDRVPTLEQDWVLLEPDMNPLAHTVPAEHRWIELSDGRVTVYEVCPPDQSQRCRVEHRLACPARPLPDLWPWLTSLRGENARRVERQNDPEPPPPPEEWPDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADI8</accession>
    <name>Q9ADI8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ordered locus">SCO2238</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC37264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626488.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028216.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2238"/>
    <dbReference type="GeneID" id="1097671"/>
    <dbReference type="KEGG" id="sco:SCO2238"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2276"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_11"/>
    <dbReference type="InParanoid" id="Q9ADI8"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="PhylomeDB" id="Q9ADI8"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC37264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="613" mass="66171" checksum="63780DA6C958B76F" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADQ7</accession>
    <name>Q9ADQ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
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            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="447" mass="46940" checksum="2410EEE5833F84A5" modified="2001-06-01" version="1">MTCCGLIISGSVASLRVEREFMRARRFCFVALLAIGLSACNSPADRGPADGVPSASSSKGSAEKGKPERVPHDPPESFTARGAVALPPEATAGRTNLLGDVRDLAVALHRTSAYVASAGRMQTLDLTTGKVVAVARPRAEALGEDDDATAPLVSADGSLVVTPFVTRQPGAGTQAPSMELEVVATMPETGKAAWSTPIKIPRAWAQRDSSTPEAHVVGFARGNVIVTVYTGYNAMTAGIDIATHQVRWTAQNIRTRAVTAEAAVGVDILDGFGPDQLAGLDPATGKEKWRTEKYIGDTTVESAGPSLVRVRGYAGDEGTRFDRLLKPGTGKVQADVPKGLDSLSCPFDQAKTLVCTSQSLLVALDSTSGKELWRLEDGQADGRFAPKVTACWHGRIYARASSTTAVALDARTGKDRPAGLDVAPVLVNEYQGLVLVDGELLAYPTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWN8</accession>
    <name>Q9EWN8_STRCO</name>
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        <submittedName>
            <fullName evidence="11">Putative ABC transporter ATP-binding protein</fullName>
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        <name evidence="11" type="ordered locus">SCO7689</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
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            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
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            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC17506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="1103127"/>
    <dbReference type="KEGG" id="sco:SCO7689"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7810"/>
    <dbReference type="eggNOG" id="COG1132">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_11"/>
    <dbReference type="InParanoid" id="Q9EWN8"/>
    <dbReference type="OMA" id="HIADNDL"/>
    <dbReference type="PhylomeDB" id="Q9EWN8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
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    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="44"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="361"/>
            <end position="594"/>
        </location>
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        </location>
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    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC17506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="608" mass="63370" checksum="C5E325D19B4F1D76" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWX0</accession>
    <name>Q9EWX0_STRCO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1756</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="100226.SCO1756"/>
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    <dbReference type="KEGG" id="sco:SCO1756"/>
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    <dbReference type="HOGENOM" id="CLU_1081488_0_0_11"/>
    <dbReference type="OMA" id="AWWQAHQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="27670" checksum="26FF134948F13FF0" modified="2001-03-01" version="1">MPRMLDVSDDVRAEIGDEEADRLLAGESAPGSYDCTSCRTPGDCEQERTSTVLFIGDETAVLAFAHAGCLPSQVVKVTEEQLQGAVRSISADQARSESAPAAPEKAAPEQAVLGVTSGLILIAGELHPALVVEPTAPIARPGTSGAGDDFLPLLIEQGFMPVTELASTPAVLHGWSVLLAMGQLHAVLQPGTNGGRPVAWWQAHQPLQVTEGWRTAANKHQQVLMFAAPVGSIGRQPREDLLRDALDKAAANGQLVAAALPLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX09</accession>
    <name>Q9EX09_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1117</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625410.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977714.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1117"/>
    <dbReference type="GeneID" id="1096540"/>
    <dbReference type="KEGG" id="sco:SCO1117"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1114"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_3_0_11"/>
    <dbReference type="InParanoid" id="Q9EX09"/>
    <dbReference type="OMA" id="NGPHAHM"/>
    <dbReference type="PhylomeDB" id="Q9EX09"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="345" mass="35393" checksum="B8C1A97678846B89" modified="2001-03-01" version="1">MTDGGRRQRRAYIGSFTAAGGPGILTATVAPDSGALTVVSGTDGLADPSYLALAPDGDTLYAVSETAEGAVAAYRVSGDRPEPAGRPVPVEGDGPTHLSLYAGHVLTANYGSGTVTAVPVRADGTLARSASGVLRHTGSGPHAQRQQGPHAHQVRPDPSGRWAVSVDLGTDSVRICTLTDGAPAVHREVALRPGSGPRHLAFHPDGSQAYVVNELAPTVTVCHWDADDGVLKPLTEVPLLPGAPAGDAYPSGIAVSPDGRFVWTATRGEDVLSVFVVEPDGLRLSATVPCGGHWPRDIAVSGGFLYAANERSGDVTWFALDPATGIPRRTGSLAVPAASCVIFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX16</accession>
    <name>Q9EX16_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Pectate lyase</fullName>
            <ecNumber evidence="4 5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1110</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the depolymerization of both polygalacturonate and pectins of methyl esterification degree from 22 to 89%, with an endo mode of action. In contrast to the majority of pectate lyases, displays high activity on highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 5"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625403.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027579.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1110"/>
    <dbReference type="CAZy" id="PL3">
        <property type="family name" value="Polysaccharide Lyase Family 3"/>
    </dbReference>
    <dbReference type="GeneID" id="1096533"/>
    <dbReference type="KEGG" id="sco:SCO1110"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1107"/>
    <dbReference type="eggNOG" id="COG5297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044863_3_1_11"/>
    <dbReference type="InParanoid" id="Q9EX16"/>
    <dbReference type="OMA" id="KIVPCQK"/>
    <dbReference type="PhylomeDB" id="Q9EX16"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PTHR33407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025099270" description="Pectate lyase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="27499" checksum="7687BFDD93717913" modified="2001-03-01" version="1">MTAVTRPRARRAVTGALGALGLSVGMLMTSGASSAQAATWPTPNGSEGVSSTLSVSGTKDYGMKRLYGTGDLGSGGQDEDQGPILELAPGAVLKNVIIGAPAADGVHCKGSCTLQNVWWEDVGEDAATFRGSSSSNVYTVSGGGAKEADDKVFQFNGAGTLNISGFAVKNFGTFVRSCGNCSTQYRRTINLNGIEVNWKGGRIAGINTNYGDSATLRNITIVGDSSKKIVPCQKYIGNDDGDEPDSNGSGADGTYCKYSSSDITYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX24</accession>
    <name>Q9EX24_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1016</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625312.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027521.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1016"/>
    <dbReference type="GeneID" id="1096439"/>
    <dbReference type="KEGG" id="sco:SCO1016"/>
    <dbReference type="HOGENOM" id="CLU_1015314_0_0_11"/>
    <dbReference type="OMA" id="MAPACRI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325014" evidence="2">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="26783" checksum="AC7CBC53DFC54218" modified="2001-03-01" version="1">MARPARSPAPSGTAVKLSALPTTAMAASPVRAAPAVRTTGVGRGERHNAYSSQQKAAASSATPTSPCSAACCHTAECGRPSGTGDPAAVGLDAPNRPGPTPRAGSWRSNSSASAHSRTRWEVSCPSRAAASPSGTKPPGTAQLRPVTSPAPRPSPAITAPRRRTRPAASEHSSTTAQATHPATEPSTAAITAITAASSRNAARTAGVPPAHAPQHAAPADSASRAAVAPACPSGAVSRGPGARCGTATARTPPASATAQGAPTGSSAPPIRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2V4</accession>
    <name>Q9F2V4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase subunit NuoM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4607</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628769.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029759.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4607"/>
    <dbReference type="GeneID" id="1100047"/>
    <dbReference type="KEGG" id="sco:SCO4607"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4679"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F2V4"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="PhylomeDB" id="Q9F2V4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
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        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
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    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
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        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="156"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="534" mass="56243" checksum="78F20408FADD42AC" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F351</accession>
    <name>Q9F351_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative peptide transport system integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5119</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629268.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030065.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5119"/>
    <dbReference type="TCDB" id="3.A.1.5.35">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100560"/>
    <dbReference type="KEGG" id="sco:SCO5119"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5202"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_4_11"/>
    <dbReference type="InParanoid" id="Q9F351"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="PhylomeDB" id="Q9F351"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="103"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC05749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="305" mass="31884" checksum="7D68F231F40A3AB7" modified="2001-03-01" version="1">MDLGASEAVTLEQPPGPDGADPRDKPRSLWTDAWHDLRRNPVFIISALVIIFLIVISIWPSLIASGSPLKCDLAKAQEGSQPGHPFGFNGQGCDVYTRTVYGARTSVAVGILATLGVALLGSVLGGLAGFFGGGGDAVLSRITDIFFAIPVVLGGLVLLSVITSNTIWPVIGFIVLLGWPQISRIARGSVITAKQNDYVQAARALGASNSRLLLRHIAPNAVAPVIVVATIALGTYISLEATLSFLGVGLKPPSVSWGIDISSAAPYVRNAPHALLWPSGALAITVLAFIMLGDAVRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F383</accession>
    <name>Q9F383_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4405</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628573.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029634.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4405"/>
    <dbReference type="GeneID" id="1099845"/>
    <dbReference type="KEGG" id="sco:SCO4405"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4473"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9F383"/>
    <dbReference type="OMA" id="HRMNEVE"/>
    <dbReference type="PhylomeDB" id="Q9F383"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC08414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="324" mass="34506" checksum="3A0E848A5B776B29" modified="2001-03-01" version="1">MTSLAITANGLRKSYGDKTVLDGIDLAVPEGTVFSLLGPNGAGKTTAVKILSTLVTPDAGDIRVGGHDLASAPQAVRGAIGVTGQFSAVDGLITGEENMLLMADLHHLPRPEGRRVAAELLERFDLTEAAGKPASTYSGGMKRRLDIAMTLVGDPRIIFLDEPTTGLDPRSRHTMWQIIRALVTDGVTVFLTTQYLEEADELADRIAVLHDGRIAAEGTAEELKRLVPGGHVRLRFTDPTAYRDATAALPHSAGDDNTLTLQIPSDGSQRDLRTILDRLDDAGIEADELTVHTPDLDDVFFALTATTAPAAVPAQTDATKETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3N4</accession>
    <name>Q9F3N4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7653</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631693.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031806.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7653"/>
    <dbReference type="GeneID" id="1103091"/>
    <dbReference type="KEGG" id="sco:SCO7653"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7773"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092691_1_0_11"/>
    <dbReference type="OMA" id="NEFCVIE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="125"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="25155" checksum="EC8EA5C65D1D3DE6" modified="2001-03-01" version="1">MTSQLFAICFNTSVPSDLARFWSGVLGWELSAGADDDLAVLPPDGAGYRLRFLPGPAPKAGQNRAHFDLTSASPQDQRATVARALRLGGKHIDVGQLPEEGHVVLADPDGNEFCVIEAGNNFLAGTGAVGALACDGTQEVGYFWSAALGWPLVWDQDQETAIHSPAGGTKITWGGPPVAPKSGANRLHLELALPADADFEAETARLLSLGATRSAAGEEARGRAFLLDPDGNEFTVTHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3P0</accession>
    <name>Q9F3P0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative calcium binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7647</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031802.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7647"/>
    <dbReference type="GeneID" id="1103085"/>
    <dbReference type="KEGG" id="sco:SCO7647"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7767"/>
    <dbReference type="eggNOG" id="COG5126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096804_3_0_11"/>
    <dbReference type="InParanoid" id="Q9F3P0"/>
    <dbReference type="OMA" id="FRRYWTT"/>
    <dbReference type="PhylomeDB" id="Q9F3P0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC16980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="19464" checksum="5C865855F44A52B1" modified="2001-03-01" version="1">MTPTSEATDRVQLVFSLFDADGNGYLEQADFDLMSDRVTAAVPAARDAVKERLTASFGGYWDTLRTELDANGDGRISPEEFTSVVLDPQRFDTAVDEFAEALAAMGDPEGDGLVARSEFIALMLAIGFERRNIETLFDAFGPDDGDRIRAATWADGIRDYYRPEKSGIPGDHLTAGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3Q3</accession>
    <name>Q9F3Q3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7634</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631674.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7634"/>
    <dbReference type="GeneID" id="1103072"/>
    <dbReference type="KEGG" id="sco:SCO7634"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7753"/>
    <dbReference type="eggNOG" id="COG4282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428887_0_0_11"/>
    <dbReference type="OMA" id="TFTTRSW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="2">
        <location>
            <begin position="47"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="633" mass="69716" checksum="9F2F3012548701E3" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBL2</accession>
    <name>Q9FBL2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5146</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629294.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030083.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5146"/>
    <dbReference type="GeneID" id="1100587"/>
    <dbReference type="KEGG" id="sco:SCO5146"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5229"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_2_0_11"/>
    <dbReference type="InParanoid" id="Q9FBL2"/>
    <dbReference type="OMA" id="RGMRPDG"/>
    <dbReference type="PhylomeDB" id="Q9FBL2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="18442" checksum="A681AF1A9FBD0099" modified="2001-03-01" version="1">MTPGTGSALGLLAAAVDAKAVAEIGTGCGVSGIHLLHGMRPDGVLTTVDPEPEHQQFARHAFRAAGFASNRARFIPGRALDVLPRLADAGYDLVFCDGDRLEYLDYLAESLRLLRPGGLVAFEGVFGAGRTIDSGPQPTEVLRVRELLRAVRESQELVPSLLPVGDGLLCAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBT0</accession>
    <name>Q9FBT0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031473.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7162"/>
    <dbReference type="GeneID" id="1102600"/>
    <dbReference type="KEGG" id="sco:SCO7162"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7263"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_5_0_11"/>
    <dbReference type="InParanoid" id="Q9FBT0"/>
    <dbReference type="OMA" id="GGGINEW"/>
    <dbReference type="PhylomeDB" id="Q9FBT0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd19162">
        <property type="entry name" value="AKR_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044477">
        <property type="entry name" value="FDH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="307" mass="32487" checksum="6689318BA869D675" modified="2001-03-01" version="1">MTPADGRRLALPRFGLGCAPIGDLYHEVDPDVAAATVHAAVDGGATLIDTAPLYGDGLSERRVGRALATVDRARFQLSTKVGWQIAEGAEPRHAFGRDDVLRSLEGSMERLGVDRFDVVHVHDPEDHLDEAVRHAVPALLRLRDEGVVGAVGAGMNHSAPLAELVRRTDLDVVLIAGRYTLLEQPALAGLLPLCAERGVGVIAAGVFNSGLLADPRPGAPYHYHPVPDDVLRRALALDDVCARYGVPLRAAAQQFPFGHPAVVSVVVGAASPQEVTGNLELAGQPIPAAMWAELREAHLLDPAVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBT1</accession>
    <name>Q9FBT1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7161</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631220.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031472.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7161"/>
    <dbReference type="GeneID" id="1102599"/>
    <dbReference type="KEGG" id="sco:SCO7161"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7262"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FBT1"/>
    <dbReference type="OMA" id="ANEDAYH"/>
    <dbReference type="PhylomeDB" id="Q9FBT1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="25944" checksum="8F0D52AA1C75AC9F" modified="2001-03-01" version="1">MTTTGSALSGALPFAGLTALVTGGASGIGLATARLLTAQGARVAVLDLSEPQPAGFAAALRADIRDDASVVAAVDAAVSRLGGLDIVVNNAGIGAQGGVEDNSDEEWHRVLDTNVVGMVRVTRAALPALRASRHAAVVNVGSIAATAGLPQRVLYSAGKGAVVAMTRAMAADLLPEGIRVNAVNPGTADTPWIGRLLDRAADPAAEYTALAARQPHGRLVAADEVAAAIAYLASPAAGSTTGTCLAVDGGMDGLRLRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC18</accession>
    <name>Q9FC18_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dienoyl-CoA reductase [NADPH]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7066</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631128.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031412.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7066"/>
    <dbReference type="GeneID" id="1102504"/>
    <dbReference type="KEGG" id="sco:SCO7066"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7171"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_1_1_11"/>
    <dbReference type="InParanoid" id="Q9FC18"/>
    <dbReference type="OMA" id="PRGAYTW"/>
    <dbReference type="PhylomeDB" id="Q9FC18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033543">
        <property type="term" value="P:fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="7"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="376"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="671" mass="71901" checksum="86A80544F8EB5F22" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCI5</accession>
    <name>Q9FCI5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5203</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030112.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5203"/>
    <dbReference type="GeneID" id="1100644"/>
    <dbReference type="KEGG" id="sco:SCO5203"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5286"/>
    <dbReference type="eggNOG" id="ENOG5032TUF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094573_0_0_11"/>
    <dbReference type="OMA" id="SGLGWDQ"/>
    <dbReference type="PhylomeDB" id="Q9FCI5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="223" mass="23985" checksum="43D43615642097A5" modified="2001-03-01" version="1">MIRQALGFAGPPCAPVIAGPHLCNLLIVYSVPDSGHERGRIVTMSNTPMAASPLTRAVLEIDEYVSGLGWDQPARLFALVDTARLRADQPSLADRLGLREEPESSGLTPIEQDEIPTDQALDEFLGTIAWPDSVVGCALAVERLMLPPSAEAQVPSGLNEKKLAQWVAEHPDRQEVRMTVAVLRDGSRDSALRLREKDTATEVLTGSDLVPGLAAALTATFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3G7</accession>
    <name>Q9K3G7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1273</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB99153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625560.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027686.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1273"/>
    <dbReference type="GeneID" id="1096696"/>
    <dbReference type="KEGG" id="sco:SCO1273"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1273"/>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_76_1_11"/>
    <dbReference type="InParanoid" id="Q9K3G7"/>
    <dbReference type="OMA" id="HDFINLM"/>
    <dbReference type="PhylomeDB" id="Q9K3G7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB99153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="372" mass="40124" checksum="0FE5F5E0A24FE0E0" modified="2000-10-01" version="1">MVSFPIAEDLRLPAEIDASALPDAPEGPPERILLTGATGFLGGFLLADLLDATDARIHCLVRAESAGEARERLAGQLRARNVPEHHMSRIDVVPGSLAKPRFGLSDEEFSGLSRGIDVIYHCGAWVNLLASYPILRGCNVSGTLEILRLATRTRRIPVHYISTMGVIPAARDAGAGVSGYCATKWVAEQLVAQAADRGTPTMVHRPGVILADSRTGLVGKSDWFVHLTTASIRAGCAPDHPGLLPVGTVDFTSRAIVELSLSRRARGQVFHVIDPEPLPFRSYFQGFADAGVDLPLVPFDTWLERLRDLGDEVPRSTLRLAGETLRQMIPAPGQDTAGPAAASAHRAPPVLDSDYFRRMLAFLNRDAVLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3S0</accession>
    <name>Q9K3S0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3144</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627361.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3144"/>
    <dbReference type="GeneID" id="1098578"/>
    <dbReference type="KEGG" id="sco:SCO3144"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3205"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9K3S0"/>
    <dbReference type="OMA" id="HDERIEG"/>
    <dbReference type="PhylomeDB" id="Q9K3S0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB95937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="23151" checksum="BE496F65E2993673" modified="2000-10-01" version="1">MGVRLMVVDDHRLLAEALASALKLRGHRVLAAAAPAAGAAELVISRAPEVCLLGTATPAEPGNFDPVVRIKRERPQVAVLVLGPVPSPRGIAAAFASGASGYVRHDERIEGVERAIMKARAGEAAVAPALLQGAFGELLNPVAQPDDEGQRLLQLLTPREVEVLVRVADGEDTRLIAAGMGIAPSTARTHVQRVLMKLGVGSRLEAAALAARTGLLDRAGASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K432</accession>
    <name>Q9K432_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1067</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625361.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027555.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1067"/>
    <dbReference type="GeneID" id="1096490"/>
    <dbReference type="KEGG" id="sco:SCO1067"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1064"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K432"/>
    <dbReference type="OMA" id="WAPLVPY"/>
    <dbReference type="PhylomeDB" id="Q9K432"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="213"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB95286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="390" mass="39190" checksum="7EFB31045BDC5F4E" modified="2000-10-01" version="1">MPGSRDDLTRLRIALTAFFALDGFVFAGWVVRIPAIKEQTGASASALGLALLGVSAGAVVTMTLTGRLVRRYGSHPVTVACAVLLCLSIALPPLTHSALALGAVLLVFGSAYGGINVAFNSAAVDLVAVLGRPIMPSFHAAFSLGGMVGAGLGGLVAGALSPTRHLLALTVTGLLVTLVAGRALLRCEPAAPPDRTPEEDGTPRRPDRRTRRLVVTFGLIALCTAYGEGAMADWGALHLEQDLDASPGLAAAGYSCFALAMTVGRLTGTTLLERLGRTATVVAGGTTAVAGMLLGSLAPSVWAALFGFAITGLGLANIFPVAIERAGALGGPSGVATASTLGYGGMLLGPPAIGFMADWFSLSAALTSVAVLAAVAVLVAVATRRAAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K460</accession>
    <name>Q9K460_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7225</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631281.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031524.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9K460"/>
    <dbReference type="STRING" id="100226.SCO7225"/>
    <dbReference type="CAZy" id="AA10">
        <property type="family name" value="Auxiliary Activities 10"/>
    </dbReference>
    <dbReference type="CAZy" id="CBM5">
        <property type="family name" value="Carbohydrate-Binding Module Family 5"/>
    </dbReference>
    <dbReference type="GeneID" id="1102663"/>
    <dbReference type="KEGG" id="sco:SCO7225"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7325"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047929_3_0_11"/>
    <dbReference type="OMA" id="DVSHQVN"/>
    <dbReference type="PhylomeDB" id="Q9K460"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176735" evidence="2">
        <location>
            <begin position="31"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="3">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB94648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="244" mass="25243" checksum="B71BEE6F1C1F9F0E" modified="2000-10-01" version="1">MRTKRRVAFAVGALVAPLLAVSLPASTASAHGWVTSPGSRQDQCAAGIVDCGQIKYEPQSVEGPKGLSSCSGGNSQFAELDDDGKGWRVTPVGTTHTFTWHHTARHATANWQYFIGSQKIAEFDGHRAQPAPDVSHQVNFGGFTGRQKVLAVWNVADTGNAFYSCIDVNIGGSGGGDGGGDGGGDGDPGACDAPGWSAGSVYSGGDTVSFGGHTWRAKWWVTGEEPGTTGEWGVWEDLGACAAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-05-23" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K487</accession>
    <name>NAGB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagB</name>
        <name type="ordered locus">SCO5236</name>
        <name type="ORF">SC7E4.33c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="61" first="1237" last="1251">
            <title>The sugar phosphotransferase system of Streptomyces coelicolor is regulated by the GntR-family regulator DasR and links N-acetylglucosamine metabolism to the control of development.</title>
            <authorList>
                <person name="Rigali S."/>
                <person name="Nothaft H."/>
                <person name="Noens E.E.E."/>
                <person name="Schlicht M."/>
                <person name="Colson S."/>
                <person name="Mueller M."/>
                <person name="Joris B."/>
                <person name="Koerten H.K."/>
                <person name="Hopwood D.A."/>
                <person name="Titgemeyer F."/>
                <person name="van Wezel G.P."/>
            </authorList>
            <dbReference type="PubMed" id="16925557"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05319.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Expression is repressed by DasR in the absence of GlcN6P.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629383.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030128.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K487"/>
    <dbReference type="SMR" id="Q9K487"/>
    <dbReference type="STRING" id="100226.SCO5236"/>
    <dbReference type="GeneID" id="1100677"/>
    <dbReference type="KEGG" id="sco:SCO5236"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5319"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_11"/>
    <dbReference type="InParanoid" id="Q9K487"/>
    <dbReference type="OMA" id="FNEPCSS"/>
    <dbReference type="PhylomeDB" id="Q9K487"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000160175" description="Glucosamine-6-phosphate deaminase">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16925557"/>
        </source>
    </evidence>
    <sequence length="261" mass="27446" checksum="FBA6020E3B78C851" modified="2000-10-01" version="1">MEVVIVPDAKAGGELIAEAMAQLLRRKPDALLGVATGSTPLPVYEALAAKVRSGAVDTAQARIAQLDEYVGLPAEHPESYRSVLRREVLEPLGIDMDAFMGPDGTAADVQAACEAYDTALGGSGGVDLQLLGIGTDGHIGFNEPCSSLASRTRIKTLTEQTRIDNARFFDGDIEQVPHHVITQGIGTILEARHVVLLATGEGKADAVAASVEGPVAAVCPASALQLHPHATVVVDEAAASKLKLADYFRHTYAHKPDWQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K497</accession>
    <accession>Q5K5X3</accession>
    <name>Q9K497_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Putative araC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nrdS</name>
        <name evidence="3" type="ordered locus">SCO5224</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Microbiology" volume="148" first="391" last="404">
            <title>Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth.</title>
            <authorList>
                <person name="Borovok I."/>
                <person name="Kreisberg-Zakarin R."/>
                <person name="Yanko M."/>
                <person name="Schreiber R."/>
                <person name="Myslovati M."/>
                <person name="Aaslund F."/>
                <person name="Holmgren A."/>
                <person name="Cohen G."/>
                <person name="Aharonowitz Y."/>
            </authorList>
            <dbReference type="PubMed" id="11832503"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="54" first="1022" last="1035">
            <title>Alternative oxygen-dependent and oxygen-independent ribonucleotide reductases in Streptomyces: cross-regulation and physiological role in response to oxygen limitation.</title>
            <authorList>
                <person name="Borovok I."/>
                <person name="Gorovitz B."/>
                <person name="Yanku M."/>
                <person name="Schreiber R."/>
                <person name="Gust B."/>
                <person name="Chater K."/>
                <person name="Aharonowitz Y."/>
                <person name="Cohen G."/>
            </authorList>
            <dbReference type="PubMed" id="15522084"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04325.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2005-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Borovok I.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="2512" last="2520">
            <title>Coenzyme B12 controls transcription of the Streptomyces class Ia ribonucleotide reductase nrdABS operon via a riboswitch mechanism.</title>
            <authorList>
                <person name="Borovok I."/>
                <person name="Gorovitz B."/>
                <person name="Schreiber R."/>
                <person name="Aharonowitz Y."/>
                <person name="Cohen G."/>
            </authorList>
            <dbReference type="PubMed" id="16547038"/>
            <dbReference type="DOI" id="10.1128/JB.188.7.2512-2520.2006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
        </source>
    </reference>
    <reference evidence="4" key="6">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="7635" last="7644">
            <title>The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons.</title>
            <authorList>
                <person name="Grinberg I."/>
                <person name="Shteinberg T."/>
                <person name="Gorovitz B."/>
                <person name="Aharonowitz Y."/>
                <person name="Cohen G."/>
                <person name="Borovok I."/>
            </authorList>
            <dbReference type="PubMed" id="16950922"/>
            <dbReference type="DOI" id="10.1128/JB.00903-06"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ276618">
        <property type="protein sequence ID" value="CAI45287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629371.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030121.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5224"/>
    <dbReference type="GeneID" id="1100665"/>
    <dbReference type="KEGG" id="sco:SCO5224"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5308"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_59_0_11"/>
    <dbReference type="OMA" id="CTFEFGI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAI45287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="35407" checksum="A22A5E6B23110596" modified="2000-10-01" version="1">MLRNVAAVLLDGAHPFELGVVCEVFGIDRSDEGLPVYDFAVVSAEGPTLGTHVGGLTVSTPYGLERLEEADLIAVPAGSDFVRREYPPDLLDALRRATDRGTRVLSVCSGVFVLGAAGLLDGRQCAVHWHHAAELARQHPRARVAPDVLYVDEDPVVTSAGTAAGIDACLHIVRKEQGPEVANRIARRMVVPPHRDGGQAQYIERPLPRSSCDTVGEVLAWMEQHLDEEVTVEQLAVRAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEATDETMDTIAWRAGFGTAAALRHQFTRALDTTPHAYRRTFRGPEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4I0</accession>
    <name>Q9K4I0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7245</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631301.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031538.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7245"/>
    <dbReference type="ESTHER" id="strco-SC7A12.12">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1102683"/>
    <dbReference type="KEGG" id="sco:SCO7245"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7345"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_0_11"/>
    <dbReference type="InParanoid" id="Q9K4I0"/>
    <dbReference type="OMA" id="FFYGRWD"/>
    <dbReference type="PhylomeDB" id="Q9K4I0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="32295" checksum="8FB252419D235EAE" modified="2000-10-01" version="1">MQTFTAHDGTRLAFHVRGEGDPLVVLPGGPMRASGHLGDLGGLAAHRRLLLLDLRGTGGSAVPQDPATYRCDRLVDDVEALREHLGLESMDLLAHSAGGSLAMLYAARQPERVSRLVLVTATPWAPDMPATPEDRLRAALLRADEPWFEEAIGPFRAWLAGTGEFDPVFAPFFFGRWDDTAREHDAGADEESNDGAGDVFLSPDAFDPPATRAALARCPAPVLVLAGERDGGPSPEPARRCADVFPRAGPAVQPGAGHYPWLDDPRWSAHRIAAFLGPNRSPSHPLARHFPRGLSAAEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY98</accession>
    <name>Q9KY98_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5004</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629156.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029997.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5004"/>
    <dbReference type="GeneID" id="1100445"/>
    <dbReference type="KEGG" id="sco:SCO5004"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5083"/>
    <dbReference type="eggNOG" id="ENOG5033R5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047966_0_0_11"/>
    <dbReference type="OMA" id="WWGTGKL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="33451" checksum="D8305AF8E3BCFC79" modified="2000-10-01" version="1">MGDGEPRVPTAIAVTSADLALPPQDERTLPAAVLQDVDRRPLESVLAELQTLVDQCGHVIVVCSQAVPASVERRLHTVRALLETDRIALFRPPLPPLGIAVLARQLRQLASCDLSPGVLASAGRLLTHYIHAGALLGSVARLDHVPVGLKAHARSWVPGSQFGVVAHPVPQLVRIGPEAALAGPEFGTWLLVAKGQHPTDWVTGSLAPSWHVQGLRETALPAESATWWGTGRLTEFCAYLPDLSVLYQLVTSVRRGTCHWCGIDVIGDRCVFCSATPPVYDDGGAGGGGRDRALAPRRDPALGRRRERRALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYZ7</accession>
    <name>Q9KYZ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7532</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631576.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971613.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7532"/>
    <dbReference type="GeneID" id="1102970"/>
    <dbReference type="KEGG" id="sco:SCO7532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7646"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993634_0_0_11"/>
    <dbReference type="OMA" id="LWMGDSI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB90890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="279" mass="28624" checksum="E78382367945E623" modified="2000-10-01" version="1">MDNEINSSGRSLPARHAVGHALVAAAVALALTGCQGSGTGVEVSASDGAAAGTPDGGTNSSDGKRDDGPRRLLWMGDSIGEAQAPALGAAMKAGGVAFRSVAAAGGGGVVGEIAAPTWDGLPKTLKSFAPDVVAYQVTTYDWGTPAEQRAAYERLVKTVNEAGADLLLVSAPPFKVDDFYRPHEAEIASAPRSAKSVAEKHPDTAGFLDAAALWGDDSASERAQRSEDGIHSCQQGSAAFAVWFGEQLEKRYGFDPAAADAWATGDWTGAKVYSRLGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZG5</accession>
    <name>Q9KZG5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">SCO6987</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM175 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031358.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6987"/>
    <dbReference type="GeneID" id="1102425"/>
    <dbReference type="KEGG" id="sco:SCO6987"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7086"/>
    <dbReference type="eggNOG" id="COG3548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694488_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9KZG5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010617">
        <property type="entry name" value="TMEM175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06736">
        <property type="entry name" value="TMEM175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="155" mass="16208" checksum="60374E8B2F103409" modified="2000-10-01" version="1">MWKPTPAGGPERVVAPAVGVFAIAITLLVLDFSVPSGLDSSACHAALRDLAPNLGAYVPSLLVLGPFRREHRRILGLVARVDGQVITLSLAGPGVAALVPFPAKLISEYGTSRSRSRSTRRRSPPRAPPTWPCSPCWSPGPGGAAARPPRKASCS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZJ5</accession>
    <name>R31B1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31 type B 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE2-1</name>
        <name type="ordered locus">SCO1150</name>
        <name type="ORF">SCG8A.04</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625442.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027612.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KZJ5"/>
    <dbReference type="SMR" id="Q9KZJ5"/>
    <dbReference type="STRING" id="100226.SCO1150"/>
    <dbReference type="GeneID" id="1096573"/>
    <dbReference type="KEGG" id="sco:SCO1150"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1148"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_2_2_11"/>
    <dbReference type="InParanoid" id="Q9KZJ5"/>
    <dbReference type="OMA" id="MQQDKHP"/>
    <dbReference type="PhylomeDB" id="Q9KZJ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00502">
        <property type="entry name" value="Ribosomal_L31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027493">
        <property type="entry name" value="Ribosomal_L31_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000173267" description="50S ribosomal protein L31 type B 1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00502"/>
        </source>
    </evidence>
    <sequence length="90" mass="10063" checksum="052902360E7AF79B" modified="2000-10-01" version="1">MQQDKHPDYRPVVFRDRGAGYAFLTRSTATSDQTIVWDDGETYPVVEVEISSESHPFYTGKARTVDSEGRVARFERRYGAGEGQDTGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L059</accession>
    <name>Q9L059_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2976</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627199.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028693.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2976"/>
    <dbReference type="GeneID" id="1098409"/>
    <dbReference type="KEGG" id="sco:SCO2976"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3035"/>
    <dbReference type="HOGENOM" id="CLU_1314801_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB87326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="209" mass="24308" checksum="34B4EF6CA3D96AB7" modified="2000-10-01" version="1">MGSNDELYEKSVLDVPKLQRYARKVAKAAHSKVPMASHQEYVVRQHQEVRRKGWFSKESVTVSERCAQGPALRYWELGRVADETFRRKDGADLYGHVHINWTGVDDGSMIILLEDGELRHVAYSVRDTGPHYPVLEMETSHTEWKVAAMRPHDYLLLDRPNLGRMREKTYSRKSGLLYMEELRRNYRVTVRQKGLGLSLALNRLLKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L065</accession>
    <name>Q9L065_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">SCO2789</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627019.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976011.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2789"/>
    <dbReference type="GeneID" id="1098223"/>
    <dbReference type="KEGG" id="sco:SCO2789"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2846"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_11"/>
    <dbReference type="OMA" id="TSYYSGC"/>
    <dbReference type="PhylomeDB" id="Q9L065"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="458"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="605" mass="66117" checksum="3558E6ADA09C35CF" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0T2</accession>
    <name>Q9L0T2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4512</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628676.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974430.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4512"/>
    <dbReference type="GeneID" id="1099952"/>
    <dbReference type="KEGG" id="sco:SCO4512"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4584"/>
    <dbReference type="eggNOG" id="ENOG5031R6K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111590_0_0_11"/>
    <dbReference type="OMA" id="LVPRDWF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB77303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="193" mass="21205" checksum="F908B7EB328AC837" modified="2000-10-01" version="1">MTTTHRSRPPDDYRLLVPRDWFRIDLMVDRWRPQLKKFVDQQATRRQMSTDAGRELWASLRNAVETGVSQGALELYLRTDVVAGTGAPATLMVSLLPMRDALHASPEEFAQALRGREEGGATVSVSSLPAGSCVRVSTTTALDYYVEMPGGAGYILLSFTVPLSGVESPLGELCEAMAGSLRWIHNAAPQEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1U0</accession>
    <name>Q9L1U0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2955</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627179.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028679.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2955"/>
    <dbReference type="GeneID" id="1098388"/>
    <dbReference type="KEGG" id="sco:SCO2955"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3014"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_3_1_11"/>
    <dbReference type="InParanoid" id="Q9L1U0"/>
    <dbReference type="OMA" id="WCSSEVC"/>
    <dbReference type="PhylomeDB" id="Q9L1U0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="196" mass="21289" checksum="5D0EB0FDE9384D3F" modified="2000-10-01" version="1">MALGTATDPYELRFDTGRISLDLIATTHPAERLDSVDALRAWITGSGLVPPGTPLAHADPSWLTGFRELRGETARLVRGRPVPHSHPYALALARVNELALAAPPAPRAVPGEDGTLVRELTGPPRCAALLGALARDVVELLTDPVARASLRQCAGDNCPIVYVDTSRGRRRRWCSSEVCGNRERVARHRRRVALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L239</accession>
    <name>Q9L239_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO6793</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630865.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031187.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6793"/>
    <dbReference type="GeneID" id="1102232"/>
    <dbReference type="KEGG" id="sco:SCO6793"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6902"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L239"/>
    <dbReference type="OMA" id="PFMGPQI"/>
    <dbReference type="PhylomeDB" id="Q9L239"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="13"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="501" mass="52023" checksum="995BA1E4822E6659" modified="2000-10-01" version="1">MTDTTPDAAPRATTFTTRSPATGEPLAEHPVDGPEEVARAVARARRAQEGWAALPAARRRERLLRWKRLLARELGTVARTVAEETGKPAGDAGLEVVLTLEHLGWAARNADRVLRRRRVRTGLFTVHQRASLVHRPLGVVGVIGPWNYPCYTPMGSVGYALAAGNAVVLKPSELTPATGLLLAALFDEAVPAHAGLFTAVTGAAATGEALVRSGVDKLAFTGSPGTARKVMAVCAETLTPFLAECGGKDAVIVTADADLDAAADAIVWGAFGNAGQTCAGVERVYAVREVHEALCERVVRRAGVLRPGAGGDAHYGPMTLPGQLETVERHVTEAVSSGARALLGGPESVRAPYVAPVVLTGAPADSAAMTEETFGPVVAVDAVADVDEAVARANDSRYALGAAVFCGSRRTGAAIAARLHAGAVSVNSVLGFAAVPALPFGGSRDSGFGRIHGAEGLRAFTAVQSTTVQRFAPPIALTSFEVPAAARERAVRLARSLHLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L267</accession>
    <name>Q9L267_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1542</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977284.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1542"/>
    <dbReference type="GeneID" id="1096968"/>
    <dbReference type="KEGG" id="sco:SCO1542"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1552"/>
    <dbReference type="eggNOG" id="COG5516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087298_1_0_11"/>
    <dbReference type="OMA" id="SRTCGNR"/>
    <dbReference type="PhylomeDB" id="Q9L267"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB70944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="186" mass="20342" checksum="E90EDEAA58848E44" modified="2000-10-01" version="1">MLITHDTRCALDTVVDLVNTVPEDESAPDGLPDVAALQEFVGTHEISDVGVLTEFDLSAVRRIRARFAAVFAAPDARTAAGLINDLVAAAGTTPRLTDHDGYDWHIHYFAPGASVADHLTADCGMALAFFVVAGEQERLRRCEAPDCRRAFVDLSRNRSRRYCDSRTCGNRLHVAAYRARRKEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2K2</accession>
    <name>Q9L2K2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0706</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978156.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0706"/>
    <dbReference type="GeneID" id="1096129"/>
    <dbReference type="KEGG" id="sco:SCO0706"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.693"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052641_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L2K2"/>
    <dbReference type="OMA" id="QAQQMWA"/>
    <dbReference type="PhylomeDB" id="Q9L2K2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176847" evidence="1">
        <location>
            <begin position="35"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="57"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="427" mass="43512" checksum="49AF2B0370D9F8CF" modified="2000-10-01" version="1">MNVKHPRPRTTRTAALAAALAAVLLAGTACSSKADGGSTDDAAADGVKSGPGVSEKSIRLGALTDLTGPYATLGKSIVQAQQMWADETNAAGGICGRKVEIVVKDHGYDVQKAVTAYADIAPDVVALPQVIGSPVVAALLDDIERDHMLTFPQAWAASLLGRDSVQVLGTTYDLDMIAAVDFLTRTKKLAKGDTIGHVYFEGDYGANALEGTEWAAEQAGMKVAGQKIKATDTDLTAQVSALGKAGVKAILISAGPAQTASLAGVAAARGLKVPIVSSAPGYAPQLLKTPAAAALEAMVHVVSAAPAVSSDLPGVKKMVASYQKAYPGEPVDSGVLSGYNAAQLTGADLKKACEGGSLARQDVVKAHRSQKNADTGLGTPQNFTYVTAPASRSTYVLKPDAKALGGLVGVEEAHKAPGVDAYLAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD69</accession>
    <name>Q9RD69_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted solute-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0808</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625109.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978052.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0808"/>
    <dbReference type="GeneID" id="1096231"/>
    <dbReference type="KEGG" id="sco:SCO0808"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.800"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RD69"/>
    <dbReference type="OMA" id="KQVNNPY"/>
    <dbReference type="PhylomeDB" id="Q9RD69"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015762">
        <property type="term" value="P:rhamnose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013459">
        <property type="entry name" value="RhaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02637">
        <property type="entry name" value="RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176863" evidence="1">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="59"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB66208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="360" mass="37979" checksum="DD262961A5E2C150" modified="2000-05-01" version="1">MRKSSIRRTCAALAAVTSLALAATACGGTTKEDVKDEGGKAAAAGKADPNAATKKGLTVGFLPKQVNNPYFTVADKGGEKALKELGSSYKEVGTSSGTDTAGQVSYVNTLTQQQVDAIAVSAQDPGALCTALKQAMKNDIKVVTYDSDTNPECRNAFISQASADDIGRTQVQQMAEQIGNKGEIAILSAAQTATNQNAWIEIMKDELKDPKYKDVKLVKVAYGDDDAQKSFQQTQGLLQEHPNLKGIISPTTVGIKAAAQYLSGSKYKGKVKLTGLGTPNDMRKYVKNGTVEAFELWDPAKLGELAARTAVALSSGQITGKEGETFKAGAMGEYTIGKNGVIDLGKPTVFTADNVDQFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDJ3</accession>
    <name>Q9RDJ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral-membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2732</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626964.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028548.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2732"/>
    <dbReference type="GeneID" id="1098166"/>
    <dbReference type="KEGG" id="sco:SCO2732"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2788"/>
    <dbReference type="eggNOG" id="COG5500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111152_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RDJ3"/>
    <dbReference type="OMA" id="AMQRINV"/>
    <dbReference type="PhylomeDB" id="Q9RDJ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="199" mass="20815" checksum="1C6D6C4E05289C02" modified="2000-05-01" version="1">MKTTQTGTLLAAVIASGLMAGLFAAFAYSVMPGLRGTSDHTFVATMQGINKAILNPVFMLPFVGTIPLIALAVFLARRGHGRPALPWLVAALVLYLVAFAVTVAANVPLNDQLERAGAPDSIGDLAAVRERFEAAWVAWNIVRALLHTAAFACLAWALVLYGADRVRTDRAAASTSGTSPAYGYGAGHERPFTAGASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI81</accession>
    <name>Q9RI81_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0095</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36995">
        <property type="entry name" value="T36995"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624440.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026843.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0095"/>
    <dbReference type="GeneID" id="1095521"/>
    <dbReference type="KEGG" id="sco:SCO0095"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.81"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160555_0_0_11"/>
    <dbReference type="OMA" id="MHAIADD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="25641" checksum="9D02FAD7C3232A39" modified="2000-05-01" version="1">MSIEVVEPPALPPQGTAVEFKVRVPPSGEITLVTGRQRVGIHQALAGRTLTVWANHRSVHFLLDGHPVTTVPSRLRPEDLAYLTMRYGARPAGPEPAPAALPRARSGTAILAAGEPVEVDRKVHRDGLVRLASGRYQVGFALASRTITLRLDGHLMHAIADDALTGTWPCPVPADRLGQIEGPRTATSPLPPPPLPAGAFRAQRKVHASGRFMINGQSIELGPRHAGKLVTVVIEDTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIT9</accession>
    <name>Q9RIT9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0968</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625265.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027479.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0968"/>
    <dbReference type="GeneID" id="1096391"/>
    <dbReference type="KEGG" id="sco:SCO0968"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.965"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1546730_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="18318" checksum="10F1C317FC164D9F" modified="2000-05-01" version="1">MARPFDPVLLLTVAAAATGRVRLNTSTLSTFHYEPPQLARQPTTLDVLSDGRLGAGVGWGGRSRSTTSSATRTGGGAARRSTVLHHATGPARPRCAESAAVGSAGSGSKGPAPAASISSQDEGASRLGSTARRAAEDAGRDPDALGTAMRINLEPGTSVDSVADQLLDFAAQVIERTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIV9</accession>
    <name>Q9RIV9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0947</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625244.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977913.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0947"/>
    <dbReference type="GeneID" id="1096370"/>
    <dbReference type="KEGG" id="sco:SCO0947"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.943"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020557_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RIV9"/>
    <dbReference type="OMA" id="NFAWLNW"/>
    <dbReference type="PhylomeDB" id="Q9RIV9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="PTHR14463"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="470" mass="53960" checksum="99499D574C93832D" modified="2000-05-01" version="1">MEWFTAPDYWLARLVFQRALAVVYLVAFLTAALQFRALLGERGLTPVPRFVERVPFRRAPSLFQWRYSDRLFAGCAWAGCAVSAALAAGLDALLPLWGAMLLWLVPWALYLSIVNVGQTWYSFGWESLLLETGFVAVFLGNEEVAPPVVVLFLLRWLLFRVEFGAGLIKMRGDECWRKLTCLDHHHETQPMPGPLSWFFHHLPKPLHRVEVAANHVTQLVVPFLLFAPHPVSTAAAALMIATQLWLVLSGNFSWLNWVTIVLALSVVRFPADAPSVAAAPLWYEVVVLAVAALLVFLSHRPVRNMISRRQVMNRSFDSLHLVNTYGAFGSVSRVRYEVVIEGTADEVARKDGDWREYEFKGKPGDPRRWPRQFAPYHLRLDWLMWFAALSPSYAGSWFGTFVERLLENDRATLKLLRSSPFPPDAPPRFVRARLFRYRYTTWRELRETGACWERTYVREYLPPTRLTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ09</accession>
    <name>Q9RJ09_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36938">
        <property type="entry name" value="T36938"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624492.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026889.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0156"/>
    <dbReference type="GeneID" id="1095580"/>
    <dbReference type="KEGG" id="sco:SCO0156"/>
    <dbReference type="eggNOG" id="ENOG502ZDNU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2234975_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="105" mass="11099" checksum="A496C6ACB7533C7F" modified="2000-05-01" version="1">MPDVVLDALAPYVDVLSVQTFPSPGARSAERALDVIGRWHERTGLPVLVADTGNWCPTVMNPGRTGSARDQRERGAARASYGSGCGRSSCSGRPPGRWCRVGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJB9</accession>
    <name>Q9RJB9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zinc-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0645</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624954.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978217.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0645"/>
    <dbReference type="GeneID" id="1096068"/>
    <dbReference type="KEGG" id="sco:SCO0645"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.629"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_11"/>
    <dbReference type="InParanoid" id="Q9RJB9"/>
    <dbReference type="OMA" id="GAWAEYT"/>
    <dbReference type="PhylomeDB" id="Q9RJB9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046187">
        <property type="term" value="P:acetaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="13"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="34857" checksum="190B4FC1091D46F5" modified="2000-05-01" version="1">MAQMLAARLHVPSRTLRLEEVPRPQPGPGEVLVKVEAAGVCLSDVHLIDGTLTPLLLRGDTVTLGHEVSGTVAGTGAGVTAWSPGQRVVLHAGERRDGVTYTRGVDYDGGWAEYALCAADAMTPLPDAIPFEQGAIIPDAVSTPWGAITETGEVRPAEAVGVWGVGGLGVHAVQLLRAIGACPVVAVDPSPVARERALAAGADLALDSADPEFRQKVGAATGGAGLAAAFDFAGVPPVREQAVSVLAPKGRLVLAGLTDKPLTVTDGTRFSYLQQRILGHYGSDMPVALPQLLRLIQGGRLDFSGSVSGVLPLAEAAEAVARLEKKEGDPIRLVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJG2</accession>
    <name>Q9RJG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0472</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624791.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027144.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0472"/>
    <dbReference type="GeneID" id="1095895"/>
    <dbReference type="KEGG" id="sco:SCO0472"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.450"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043135_0_0_11"/>
    <dbReference type="OMA" id="DCPGVHG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176905" evidence="2">
        <location>
            <begin position="36"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="402" mass="42123" checksum="976FDACA4F18DABC" modified="2000-05-01" version="1">MNTSIRNRAVTGTALALAVSAVLTACGGDTSSSDATSKGGGSTPSATPAASVQDPLVATFDGGLYILDGKSLELTRTIDLPGFNRVNPAGDKDHVVVSTDRGFRLLNATRQALTDIEYKGAKPGHVVRHAGKTVLFTDGTGEVNVFAPGDLGTGEKPDGRTYRSAEAHHGVAIELSDGRLLTTLGDEEKRTGALVVDKDGKEIARSENCPGVHGEAAARGEAIALGCEDGVLIYKDGRFTKVDAPDDYGRTGNQAGSDASPVLLGDYKSDPDAELERPTRISLIDTGTAKLRLVELGTSYSFRSLARGPHGEALVLGTDGAIHVIDPDKGTVEKKIPAVGQWQEPLDWQQARPTLFVRGHTAYVSEPGKKAVHAIDLESGRKRTSVTLPQGTNELSGTVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJG7</accession>
    <name>Q9RJG7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0467</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624786.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027139.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0467"/>
    <dbReference type="GeneID" id="1095890"/>
    <dbReference type="KEGG" id="sco:SCO0467"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.445"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070871_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJG7"/>
    <dbReference type="OMA" id="HPRPDFK"/>
    <dbReference type="PhylomeDB" id="Q9RJG7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="26766" checksum="FC2868C7E725901C" modified="2000-05-01" version="1">MTGSEGFVAIGQRTRSGRPAQGGTDTTGNRPGRTTMTETIAGIGIPDSSLAREATELVRDTTPPLIFHHSRRVYLFGSLQAAALGLRPDPELLYVAALFHDTGLVPPYRGDDQRFEMDGADQARAFLLAHGVPEADADTVWTAVALHTTPEVPYKLAPEIAATTAGVETDVLGLHLARITRAEIDAVTAAHPRPDFKKQILQAFTDGFGHRPQTTFGTVNADVLEHFLPGFRRTDFVEVIENSAWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJY0</accession>
    <name>Q9RJY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1190</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625480.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027641.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1190"/>
    <dbReference type="GeneID" id="1096613"/>
    <dbReference type="KEGG" id="sco:SCO1190"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1189"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q9RJY0"/>
    <dbReference type="OMA" id="KGETWGW"/>
    <dbReference type="PhylomeDB" id="Q9RJY0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="33"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="533" mass="54474" checksum="49C650E9797FEF77" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJZ5</accession>
    <name>Q9RJZ5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625465.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027629.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1175"/>
    <dbReference type="ESTHER" id="strco-SCG11A.06c">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1096598"/>
    <dbReference type="KEGG" id="sco:SCO1175"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1173"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_16_1_11"/>
    <dbReference type="InParanoid" id="Q9RJZ5"/>
    <dbReference type="OMA" id="RNDNERA"/>
    <dbReference type="PhylomeDB" id="Q9RJZ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="14658" checksum="BE1D3F73C95CFFF8" modified="2000-05-01" version="1">MCPMLDDRNDSASAHQMDGVDVWDRGWNGFGWKALLGSGCGAPDVSPCAAPARATDLSGLPPAFIDVGSAETLRDEAVAYAERIWRAGGSAELHVWSGGYHTFDLVVPDAVISRAAWQARRSWWERVLAADRRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK96</accession>
    <name>Q9RK96_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0266</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624596.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026972.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095690"/>
    <dbReference type="KEGG" id="sco:SCO0266"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.239"/>
    <dbReference type="eggNOG" id="COG4977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_2_11"/>
    <dbReference type="InParanoid" id="Q9RK96"/>
    <dbReference type="OMA" id="HKHDFFI"/>
    <dbReference type="PhylomeDB" id="Q9RK96"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="210"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="34871" checksum="0ED427317112B7FB" modified="2000-05-01" version="1">MALLVRCPGRLPRVSIEPLAPGPGIGVSGRAMVKTGHVSAIRQMTYQPPGRGAASVETMTFGRLRELNDGGTQRADFHVLAVVDAGRGSVTVDFRLHPLQDRSAVWIPPGAVHRWDDVAEVEGHLVLFVPTAPVTHATRELVASPDPAAHWIVPAADWPFVDAARGHLRLEASAPPSDSSTELPAILLSALIARLHPPHAEARLAHPVVRLFRSSVEANFRQHHDAGYYARTLGYAPRTLSRAVRQATGRTAKAYLVERLVLEAKRLLAHERLTAARCAGVLGFPDASNFSVFFHKATGERPGAWQAAATGPGVPTASTPPEPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKE1</accession>
    <name>Q9RKE1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polyguluronate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3497</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627698.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029033.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3497"/>
    <dbReference type="CAZy" id="PL7">
        <property type="family name" value="Polysaccharide Lyase Family 7"/>
    </dbReference>
    <dbReference type="GeneID" id="1098933"/>
    <dbReference type="KEGG" id="sco:SCO3497"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3555"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081538_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKE1"/>
    <dbReference type="OMA" id="FKAGCYT"/>
    <dbReference type="PhylomeDB" id="Q9RKE1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014895">
        <property type="entry name" value="Alginate_lyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08787">
        <property type="entry name" value="Alginate_lyase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176934" evidence="1">
        <location>
            <begin position="36"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_lyase2" evidence="2">
        <location>
            <begin position="46"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="259" mass="27382" checksum="3F1F95166005F4FF" modified="2000-05-01" version="1">MSRTRKRTLATTGVAALSALAALTLPLVTGGTATAAAPCDYPAQQLNLTNWKVTLPTGSSGSPTEVKQPSLATFSASPWFTVNSACTGVQFRSAVNGVTTSGSSYARSELREMTSNGTKNASWSATSGTHTMTFREAFNKLPNDKPHVVGAQIHDGDDDVTVFRLEGTSLYITKGNDTHHKLVTSNYKLNTVFEGKFVVSGGQIKAYYNGVLQTTIAHSASGNYFKAGGYTQANCGNSSPCSSSNYGQVSVYKLLVNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKF5</accession>
    <name>Q9RKF5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar-permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3482</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627685.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029021.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3482"/>
    <dbReference type="GeneID" id="1098919"/>
    <dbReference type="KEGG" id="sco:SCO3482"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3541"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="InParanoid" id="Q9RKF5"/>
    <dbReference type="OMA" id="VATWMMA"/>
    <dbReference type="PhylomeDB" id="Q9RKF5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="293" mass="31611" checksum="EAF00652D7D6E4AE" modified="2000-05-01" version="1">MTTPVHSALRAGTATPAADRITRKQRRESAAGWAKTAVMSVVTLVALAPIIMILVLSVRSGQTASGTYSWNFSNYVEIFSKTPVLDYLYNSLAVTLGTTVFAVVIGALAGYPMSRLRNRFIGGYTLSLFVVQSLPVIVFVIPLFVVFAKIGMADTLSGVAVIFIAGGMAVTCWMMAAYYDSIPVELEEAAWVDGASLWGGFVRVVLRNSYPGILSAAIFSFLVAWNDYLVATVFLRSQSNFTLPIGLQTYFQQNATDWGPVMAMSVVMLLPPVIVFAVLNRFFSIGGIGGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKR6</accession>
    <name>Q9RKR6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2262</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50571">
        <property type="entry name" value="T50571"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028232.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2262"/>
    <dbReference type="GeneID" id="1097695"/>
    <dbReference type="KEGG" id="sco:SCO2262"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2299"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKR6"/>
    <dbReference type="OMA" id="IDTDVMV"/>
    <dbReference type="PhylomeDB" id="Q9RKR6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="2">
        <location>
            <begin position="31"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="239" mass="24946" checksum="72B3F159A363EDE6" modified="2000-05-01" version="1">MTSTDSAAQKAPDKAPAKDPWDLPDVSGLVVGVLGGTGPQGKGLAYRLAKAGQKVIVGSRAAERAAAAAEEIGHGVEGADNAETARRSDVVIVAVPWDGHGKTLESLRAELSGKLVVDCVNPLGFDKKGAYALKPEEGSAAEQAAALLPDSRVAAAFHHLSAVLLQDPEIDEIDTDVMVLGEERADVEIVQALAGRIPGMRGVFAGRLRNAHQVESLVANLISVNRRYKAHAGLRVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL61</accession>
    <name>Q9RL61_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0425</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624746.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978441.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0425"/>
    <dbReference type="GeneID" id="1095848"/>
    <dbReference type="KEGG" id="sco:SCO0425"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.401"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064249_0_0_11"/>
    <dbReference type="OMA" id="NDHRWHK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029475">
        <property type="entry name" value="PmoA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14100">
        <property type="entry name" value="PmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34572" checksum="E7B55A95035EC776" modified="2000-05-01" version="1">MTLSLTHVHGDRVTVAHGAAGTELFSYVYRPEAAWEAPKPYLHPVRTLSGAVVTDYRPNDHRWHKGLQLTASHLSGQNLWGGNTYVHGEGYRALPERVGSMAHVSFEEIGAEADHAVIAERLTWHPHGGELWAEEERRIEVRDVDPDTGSWTLTWTSAVTNRRAEPLRFGSPTTHGRPAAGYTGLFWRGPRAFRGGRVFTAQSAASAESGEPADAGPMGSSARWLAYVGEHDGRDGHATLVFEHAPSNDHSGEKGTHPAHWFVRSDPFAAVAPSWAFHEELVLPPGETLARAYRVVVADGAWDRARVAAHLAGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1R6</accession>
    <name>Q9S1R6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0225</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37140">
        <property type="entry name" value="T37140"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624557.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0225"/>
    <dbReference type="GeneID" id="1095649"/>
    <dbReference type="KEGG" id="sco:SCO0225"/>
    <dbReference type="HOGENOM" id="CLU_1795333_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="14559" checksum="928EF6E9639C8C64" modified="2000-05-01" version="1">MTEKQSCLSDHLACVRDCGLVVTARTAAVPAITATVRAVTGGQVRGGVRVDSGDWCGLTVGEAGDQPSYLGEGHVSVPPATAADPGSHPGRSSVSRSGRTPSMRKPQVGRKSPAGVLGLAQGCVWVSGPMVLGRCVDSVGSYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S284</accession>
    <name>Q9S284_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36769">
        <property type="entry name" value="T36769"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626020.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027953.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1747"/>
    <dbReference type="GeneID" id="1097178"/>
    <dbReference type="KEGG" id="sco:SCO1747"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1765"/>
    <dbReference type="eggNOG" id="COG3358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093051_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S284"/>
    <dbReference type="OMA" id="CAFADHF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="30441" checksum="90365D9029B9718F" modified="2000-05-01" version="1">MTKGSPGDTPDKASDRAARGASDASDASDAWRRWHEQRVATVSAPYGPLALTGTHWLEDHPDGQLPDIPGRWTTDGDAVLLTAGRADGLTVDGRLLDGEARLTADRGPVGAARVARGERRLVVLVREGLWGVRDFDPAAPARRAFRGIAATPYDPRWSVPGRFTPYDTGRRSVRVPNADGRERGLALGGELAFELDGRAHTLQVGVEDDGSLWAVFADATSGSTSYRFRFLRPAAPDAEGRTTVDLNRALLPPCAFADHFVCPFPPPGNTLGARVEAGERELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2J6</accession>
    <name>Q9S2J6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2007</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35752">
        <property type="entry name" value="T35752"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626268.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028091.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2007"/>
    <dbReference type="GeneID" id="1097441"/>
    <dbReference type="KEGG" id="sco:SCO2007"/>
    <dbReference type="eggNOG" id="ENOG50320TB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095344_0_0_11"/>
    <dbReference type="OMA" id="RNTRAIQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="198" mass="21250" checksum="634EE158E77CEB71" modified="2000-05-01" version="1">MSGVGPVEPGEDTHVRDVPQPRPRGPLALRYDRHRRTVLASAAALVVLSGGGYLYTSRPQPRPAPPPPYPSQAVDLVYVAPVTGSPSTRAAGYSFTVLLSVRSGPPVTVTRLTQPYDGLSVTTSPAAPFQTNSHSARKIVVTLRVTECEKAPRNPGLPFLDVTLRNVRAIEAHSFILGSRYAQDLSRALEVACSNDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2W2</accession>
    <name>Q9S2W2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2094</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34964">
        <property type="entry name" value="T34964"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626353.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976721.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2094"/>
    <dbReference type="GeneID" id="1097528"/>
    <dbReference type="KEGG" id="sco:SCO2094"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2127"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S2W2"/>
    <dbReference type="OMA" id="FMARVSI"/>
    <dbReference type="PhylomeDB" id="Q9S2W2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="39"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="232"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="36704" checksum="DD3BBABD0DF286A1" modified="2000-05-01" version="1">MGEDLTAVVERVRGSVEDVIEGKPEVVRLSLTVLLAEGHLLIEDVPGVGKTMLAKALARSIDCSVRRIQFTPDLLPSDITGVSIWDQQRRDFEFKPGAIFAQVVIGDEINRASPKTQSALLESMEERQVTIDGQTYELPSPFMVVATQNPVEMEGTYPLPEAQRDRFMARVSIGYPSPEAELQMLDVHGGASPLDDLQPVAHAHDILKLIEAVRGVHVADPVRRYAVDLVAATRTHPDLRLGASPRATLHLLRAAKASAALSGRDYALPDDVQALAVAVLAHRLLPTAQAQLNRRTAEQVVQEILQRTAVPAEPQQQTGFGVGRGTPAYGQQPPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Q3</accession>
    <name>Q9X7Q3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1_PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6747</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35272">
        <property type="entry name" value="T35272"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630820.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031152.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6747"/>
    <dbReference type="GeneID" id="1102186"/>
    <dbReference type="KEGG" id="sco:SCO6747"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6854"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_1_11"/>
    <dbReference type="InParanoid" id="Q9X7Q3"/>
    <dbReference type="OMA" id="HWAWRDM"/>
    <dbReference type="PhylomeDB" id="Q9X7Q3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="22392" checksum="1124EBC2FFCF76E9" modified="1999-11-01" version="1">MRTAIVLFDRFTALDAVGPYETMSRIPGAETVFVAERTGPVRNDTGSLALTADRTLADVPDPDVVVVPGGPGQDAQMGNETLLDWLRAADAASTWTTSVCSGSLLLAAAGLLSGRRATSHWLALDLLKQYGAEPTGERVVTDGKYVTAAGVSSGIDMGLTLVGRIAGDEHAQAVQLLTEYDPQPPYDAGSPDKAPAYLVEEFRTRNRFILN</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7X4</accession>
    <name>Q9X7X4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6779</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35419">
        <property type="entry name" value="T35419"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630851.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031176.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6779"/>
    <dbReference type="GeneID" id="1102218"/>
    <dbReference type="KEGG" id="sco:SCO6779"/>
    <dbReference type="HOGENOM" id="CLU_2829221_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="66" mass="7032" checksum="D4DFCFB3BCE3AD2C" modified="1999-11-01" version="1">MSNGRDRGFVGAASQAWGRFDGRGPIRGRGPCGAGCADATQAGRISLMRSDMDRDMACRPSNWTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7X5</accession>
    <name>Q9X7X5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6780</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35420">
        <property type="entry name" value="T35420"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630852.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972218.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X7X5"/>
    <dbReference type="STRING" id="100226.SCO6780"/>
    <dbReference type="GeneID" id="1102219"/>
    <dbReference type="KEGG" id="sco:SCO6780"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6888"/>
    <dbReference type="eggNOG" id="ENOG502Z8CU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677289_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7X5"/>
    <dbReference type="OMA" id="FYMFDQF"/>
    <dbReference type="PhylomeDB" id="Q9X7X5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="PTHR37539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177005" evidence="1">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="124"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="401" mass="43416" checksum="754C8FDD4F68191F" modified="1999-11-01" version="1">MENLSRRGVLSLGVALGLVGVADGAKAWAWPSADSVAGAGTGADPEYVWDSATDPLMAALLENGSVPSINTAMAGWVNNADPLPGGFPAELTAHLRQVNRLPSWADRTKLTRAADFNRRRDTYLFMLYGLGSGIMSTVIPREARSVYWSAGGADMQDRAAKTFTFGYDLSQLKAFEPTGQFVVTANKTRLVHAAVRHLLPRSPHWTSGADQDIPISAADILVTFHSLGTYVRSKLIEWKVPFPAADQEAFLHSWQVALHLLGVPDEYIPKTWAAAEAQSAQVLTPILAPTTEGIKLAEELLGLTAQIDLGVTRGFLNEFVRYVLSDEVGDWLGLRRDPVAAALVRTAWPAYIKFREGLSPIMPGTFYLVDQFVRALAMLFLNKGSSGATTPITIPTGNRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X824</accession>
    <name>Q9X824_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP/GTP-binding integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6057</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35849">
        <property type="entry name" value="T35849"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630166.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030622.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6057"/>
    <dbReference type="GeneID" id="1101498"/>
    <dbReference type="KEGG" id="sco:SCO6057"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6158"/>
    <dbReference type="eggNOG" id="COG1485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_4_0_11"/>
    <dbReference type="InParanoid" id="Q9X824"/>
    <dbReference type="OMA" id="PKAFGTF"/>
    <dbReference type="PhylomeDB" id="Q9X824"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="350" mass="37527" checksum="3A7114DB11823BA1" modified="1999-11-01" version="1">MSLCAREPRVPADRLVAEMVPPPRFDSVRFGTYVPDPNQPSQSEAVRVLEDFAGGLGEAPGTGGGRRGFFGLGRGRAPKTPAGPRGVYLDGGYGVGKTHLLASLWHATPAEPSRKAFGTFVELTNLVGALGFQQTVQTLSGHRLLCIDEFELDDPGDTVLVSSLLARLVEAGVALAATSNTLPGKLGEGRFAAADFLREIQGLSAHFRALRIDGEDYRHRGLPEAPAPYSDEQVTRAARATEGASLDDFAALLDHLARVHPSRYGALTDGLTAVCLTGVHPVPDQSTALRLVVLADRLYDREVPVLASGLPFDRLFGEEMLKGGYRKKYFRAISRLTALARDAARLVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8A1</accession>
    <name>Q9X8A1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3525</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36166">
        <property type="entry name" value="T36166"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627725.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029061.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3525"/>
    <dbReference type="GeneID" id="1098961"/>
    <dbReference type="KEGG" id="sco:SCO3525"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3582"/>
    <dbReference type="eggNOG" id="ENOG5030MMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129892_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB41065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="146" mass="15376" checksum="9F78CBD8FA94265C" modified="1999-11-01" version="1">MPSPRTSAPSTTTGSDALLYLLFGILGSAMAFGSLAWLTGNLTNTFVGSGTWAPFRVTEALLHPEVLWPALSTSMLMVGARVVPALFTVALVVTATVLWTRWRAGAKSGLARKADLAPLLNKEIGAKAKSLRPSLGGRESKRGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8F2</accession>
    <name>Q9X8F2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3279</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36239">
        <property type="entry name" value="T36239"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627491.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975556.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3279"/>
    <dbReference type="GeneID" id="1098713"/>
    <dbReference type="KEGG" id="sco:SCO3279"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3339"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8F2"/>
    <dbReference type="OMA" id="TVRVMMD"/>
    <dbReference type="PhylomeDB" id="Q9X8F2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="8"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB40337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="42265" checksum="9EB8716B5C882D93" modified="1999-11-01" version="1">MSHPGTLVLILAAAVLAPLLVHATGRRVRVPLVIFEISLGIVMGPDVLGWARPDDVVDTLADLGLSMLIFLAGYEIDFAAVRGDTLRRSLWSWPVALVAGIALALLVSGGDVFEAFVIGTALTSTTLGTVLPMLRDSGELRGRFGTVISAFGAVGEFGPVIAVALLLSGRRPAESAALLAAFGAITTAAVFWALRPRPPWFARLTERTLHTSGQFAVRFVMLLLACMLGLAEVFGLDVLLGAFAAGVLTRLVLLRAAPASSGEVLGKVEAMGFGFLVPLFYVVTGIEFDLAALLHDPGALLLVPGFLLLFLLVHGGPVYLLAPRDLGRGDRAALALFTSTCLPLVVAITTIGVDQELIATDRAASLVGAAMVSVLVFPLLAARVRATDRTAPVTDGAAEDSEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8U6</accession>
    <name>Q9X8U6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3910</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36597">
        <property type="entry name" value="T36597"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628096.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3910"/>
    <dbReference type="GeneID" id="1099346"/>
    <dbReference type="KEGG" id="sco:SCO3910"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3984"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_16_3_11"/>
    <dbReference type="InParanoid" id="Q9X8U6"/>
    <dbReference type="OMA" id="MDGIWLA"/>
    <dbReference type="PhylomeDB" id="Q9X8U6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="46273" checksum="D4B85DDAC3BF919E" modified="1999-11-01" version="1">MVLMTQAPARTRTVRRRHDREIVALAVPAFGALVAEPLFVMADSAIVGHLGTAQLAGLGIASALLTTAVSVFVFLAYATTAAVSRRVGAGNLQAAIRQGMDGIWLALLLGAAVVAVFLPAAPSLVELFGASDTAAPYATTYLRISSLGIPAMLVVLASTGVLRGLQNTRTPLYVAVAGFIANAVLNVLLVYGAGLGIAGSAWGTVIAQCGMAAVYLWVVVRGARQHGASLRPDLVGIRASAQAGMPLLVRTLSLRAILMIATAVAARLGDADIAAHQIVLSLWSLLAFALDAIAIAGQAIIGRYLGADDAQGAREACRRMVEWGVAVGVVLGLLVVLSRPVFLPLFTGDSMVTDAALPALVIVAVAQPVCGVVFVLDGVLMGAGDGPYLAWAMLLTLAVFTPAALLVPTLGGGLTALWAAMTLMMAMRLVTLWLRTRSGRWIVTGATR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W0</accession>
    <name>DCDB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="1">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcd</name>
        <name type="ordered locus">SCO3678</name>
        <name type="ORF">SCH35.46</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dCTP deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="1"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36613">
        <property type="entry name" value="T36613"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627870.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975261.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8W0"/>
    <dbReference type="SMR" id="Q9X8W0"/>
    <dbReference type="STRING" id="100226.SCO3678"/>
    <dbReference type="GeneID" id="1099114"/>
    <dbReference type="KEGG" id="sco:SCO3678"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3737"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_2_0_11"/>
    <dbReference type="InParanoid" id="Q9X8W0"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="PhylomeDB" id="Q9X8W0"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015949">
        <property type="term" value="P:nucleobase-containing small molecule interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000156015" description="dCTP deaminase, dUMP-forming">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <sequence length="191" mass="21496" checksum="6352A496990F910C" modified="1999-11-01" version="1">MLLSDKDIRAEIDNGRVRIDPFDDSMVQPSSIDVRLDRYFRVFENHRYPHIDPSVEQVDLTRLVEPEGDEPFILHPGEFVLASTYEVVSLPDDLASRLEGKSSLGRLGLVTHSTAGFIDPGFSGHVTLELSNLATLPIKLWPGMKIGQLCLFRLTSPAEHPYGSERYGSRYQGQRGPTASRSFLNFHRTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X921</accession>
    <name>Q9X921_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3556</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36677">
        <property type="entry name" value="T36677"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627754.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029083.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3556"/>
    <dbReference type="GeneID" id="1098992"/>
    <dbReference type="KEGG" id="sco:SCO3556"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3612"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_8_0_11"/>
    <dbReference type="InParanoid" id="Q9X921"/>
    <dbReference type="PhylomeDB" id="Q9X921"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="186"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB38493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="523" mass="54132" checksum="4E7FA1A590082754" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Y2</accession>
    <name>Q9X9Y2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1890</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36904"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028033.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1890"/>
    <dbReference type="GeneID" id="1097324"/>
    <dbReference type="KEGG" id="sco:SCO1890"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1915"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_4_11"/>
    <dbReference type="InParanoid" id="Q9X9Y2"/>
    <dbReference type="OMA" id="YQSEFHA"/>
    <dbReference type="PhylomeDB" id="Q9X9Y2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB46391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="222" mass="24237" checksum="5AD6B853D4DAB22A" modified="1999-11-01" version="1">MTSVPTPIPSRTQYVLEEIKRRILTGRLTPGQALVETDLAAQFGVSKTPVREALKTLAGTGLVVMSQYKGVTVRMVDADMAREVYDVRLLLEPEALRRAVRREASLDAAREALNRADRATDTAERSLANREFHRALYVPCGNPLLGRMLDEVRDQAALVSAVAWAADPSWEREAGEHQEILRLALAGDADGAARALHAHIASFVERAFPEAGNAAQEEDGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Y6</accession>
    <name>Q9X9Y6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1886</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36900">
        <property type="entry name" value="T36900"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626152.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976934.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1886"/>
    <dbReference type="GeneID" id="1097320"/>
    <dbReference type="KEGG" id="sco:SCO1886"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1911"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_11"/>
    <dbReference type="InParanoid" id="Q9X9Y6"/>
    <dbReference type="OMA" id="WNHFLFA"/>
    <dbReference type="PhylomeDB" id="Q9X9Y6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB46387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="298" mass="32483" checksum="6793AC32E96404B1" modified="1999-11-01" version="1">MITKEAPAAAPAPTPVAPAAARPGKKRPAWDEVPRWQIYLPLGIYLVFTLIPFYWILLFALRPTGSTSLVPWPMTTEHFEKVWTDRGFGTYFTNSVYVGLATLVMTTLVALAGGYALARFDFRIKRGFMLALLCSQFVPGALLLVPLFEIFAGLQMINSLGSVIIAETVFQLPLSIILISNFIKNVPYSLEEAAWVDGCGRFRAFRIVVLPLLRPGLIAVGSFAFVHSWNHFLFALMFLNNQSKQTIPVGLNSLMSADSVDLGALAAGGIVAAVPVVIVFAFIQKWLITGFSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA56</accession>
    <name>Q9XA56_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3822</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36503">
        <property type="entry name" value="T36503"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975113.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3822"/>
    <dbReference type="GeneID" id="1099258"/>
    <dbReference type="KEGG" id="sco:SCO3822"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3890"/>
    <dbReference type="eggNOG" id="ENOG502ZPJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111456_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XA56"/>
    <dbReference type="OMA" id="TDMVEQP"/>
    <dbReference type="PhylomeDB" id="Q9XA56"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB46945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="19535" checksum="119B23A161B392CC" modified="1999-11-01" version="1">MEMPRNDRSPENPQILVVGQDGMALSGGGDDDSREIPVTEQVEQPAKVMRIGSMIKQLLEEVRVAPLDEASRVRLKEIHASSVKELEDGLAPELVEELERLSLPFTDDGTPTDAELRIAQAQLVGWLEGLFHGIQTTLFAQQMAARAQLEQMRRALPPGAVPEGEEPPHPGGRSGGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA60</accession>
    <name>Q9XA60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3817</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB46940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36498">
        <property type="entry name" value="T36498"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628006.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975118.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3817"/>
    <dbReference type="GeneID" id="1099253"/>
    <dbReference type="KEGG" id="sco:SCO3817"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3885"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XA60"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="PhylomeDB" id="Q9XA60"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="95"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB46940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="417" mass="45425" checksum="01A75B130DDCEAEE" modified="1999-11-01" version="1">MTESTAARKPRRSAGSKAAGTTGTKAAGTTGSKAGTGKRTTRTTSTTRTAAEKGSDTELVQLLTPEGERVEDAAHAEYASYVADITPDELRGLYRDMVLTRRFDAEATALQRQGELGLWASLLGQEAAQIGSGRATREDDYVFPTYREHGVAWCRGVDPTNLLGMFRGVNNGGWDPNSNNFHLYTIVIGSQALHATGYAMGVAKDGADSGVIAYFGDGASSQGDVSEAFNFAAVYNAPVVFFCQNNQWAISESNEKQTRVPLYQRAQGFGFPGVRVDGNDVLASLAVTRWALDRARRGEGPALIEAYTYRMGAHTTSDDPSRYRHDDERAAWEAKDPILRLRRFLESANHADEGFFAELEAESETLGKRVREVVRAMPDPDRFAIFENVYADGHALVDEERAQFAAYQASFADAEGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI3</accession>
    <name>Y3619_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein SCO3619</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3619</name>
        <name type="ORF">SC66T3.30c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-08" db="EMBL/GenBank/DDBJ databases">
            <title>Nucleotide sequence analysis and genetic characterization of the recR gene of Streptomyces.</title>
            <authorList>
                <person name="Pelaez A.I."/>
                <person name="Ribas-Aparicio R.M."/>
                <person name="Gomez A."/>
                <person name="Rodicio M.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="AF151381">
        <property type="protein sequence ID" value="AAD34031.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35387">
        <property type="entry name" value="T35387"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627814.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975320.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAI3"/>
    <dbReference type="SMR" id="Q9XAI3"/>
    <dbReference type="STRING" id="100226.SCO3619"/>
    <dbReference type="GeneID" id="1099055"/>
    <dbReference type="KEGG" id="sco:SCO3619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3677"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_4_0_11"/>
    <dbReference type="InParanoid" id="Q9XAI3"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000170446" description="Nucleoid-associated protein SCO3619">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <sequence length="115" mass="11729" checksum="668E1CEDC2E8EB75" modified="1999-11-01" version="1">MIPGGGQPNMQQLLQQAQKMQQDLAKAQEELARTEVDGQAGGGLVKATVTGSGELRGLVIDPKAVDPEDTETLADLVVAAVQAANENAQNLQQQKLGPLAQGMGGGGSGIPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ0</accession>
    <name>Q9XAQ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4558</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34628">
        <property type="entry name" value="T34628"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628720.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029731.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4558"/>
    <dbReference type="GeneID" id="1099998"/>
    <dbReference type="KEGG" id="sco:SCO4558"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4630"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_1_11"/>
    <dbReference type="InParanoid" id="Q9XAQ0"/>
    <dbReference type="OMA" id="PDVMEFH"/>
    <dbReference type="PhylomeDB" id="Q9XAQ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="187" mass="21030" checksum="891D606B3148E0E9" modified="1999-11-01" version="1">MKRPLPVVRLRVPTDEDAVAWHRIFDDPDVMEFHGGRAAELSVYEELTARQRRHDAEHGFCLWTMVDESGQVIGFTGAQPWPGDWGPEGEIEIGWRLGRAHWGKGYVTAAARQTLERVRDAGVAEVVAMVNARNARSIAVTERLGMRLAEVFTIPSSEQRGHCYRLDLHQQRTPGMTQGNRLSQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBI7</accession>
    <name>Q9ZBI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminoacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6487</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35974">
        <property type="entry name" value="T35974"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630570.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030958.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6487"/>
    <dbReference type="GeneID" id="1101926"/>
    <dbReference type="KEGG" id="sco:SCO6487"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6588"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBI7"/>
    <dbReference type="OMA" id="GTDAKQF"/>
    <dbReference type="PhylomeDB" id="Q9ZBI7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="204"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="443" mass="47786" checksum="072F433E63F49421" modified="1999-05-01" version="1">MAEHTGTGPDTGEQALDEVVRFTSELIRIDTTNRGGGDCQERPAAEYAAARLAEAGIEPTLLERTAGRTNVVARIEGTDPSADALLVHGHLDVVPAEAADWSVHPFSGEIRDGVVWGRGAVDMKNMDAMILAVVRDWARRGVRPRRDVVIAFTADEEASAEDGSGFLADRHAALFEGCTEGVSESGAFTFHDGAGRQFYPIAAGERGTGWLKLTARGRAGHGSKVNRENAITRLAAALTRIGDHAWPLRLTPTVRAALTEIAGVYGIETDLSDVDALLDKLGQAGKLVESTVRNSTNPTMLDAGYKVNVIPGEAVAHVDGRFLYGAEDEFRSTLDRLTGPDVDWEFVHREVALQAPVDSPTYARMRAAVEEFAPEGHVVPYCMSGGTDAKQFSRLGITGYGFAPLKLPEGFDYQALFHGVDERVPVEALHFGVHVLDRFLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN0</accession>
    <name>Q9ZBN0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6179</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35486">
        <property type="entry name" value="T35486"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630283.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030715.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6179"/>
    <dbReference type="GeneID" id="1101620"/>
    <dbReference type="KEGG" id="sco:SCO6179"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6289"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBN0"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="PhylomeDB" id="Q9ZBN0"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA22513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="35494" checksum="BEE35C1C5A9338BB" modified="1999-05-01" version="1">MTESPGATGPRSGRTWRRALVTGGAGFVGSHLCGRLLDAGTEVVCLDNLATGSRANVADLERRRGFRFVRGDATDPAALRGLPGRFDLVLHFACPASPADYLRLPLETLDVGSTGTRNALERAHADGARFLLASTSEVYGDPLEHPQRETYWGNVNPIGPRSVYDESKRFAEALVTAHRQVHGTDTAIVRIFNTYGPRMRTGDGRAVPTFIAQALDGMPLTVAGDGGQTRSLCYVDDTVAGVLALAASGESGPMNIGGDDEITMLELARRVVGLTGSGSRIRFVERPVDDPCRRRPDTTLARERLGWRPGVSWNEGLERTIGWFAHAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZC03</accession>
    <name>Q9ZC03_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6510</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34740">
        <property type="entry name" value="T34740"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630592.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030973.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6510"/>
    <dbReference type="GeneID" id="1101949"/>
    <dbReference type="KEGG" id="sco:SCO6510"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6612"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057148_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZC03"/>
    <dbReference type="OMA" id="WWGGMWA"/>
    <dbReference type="PhylomeDB" id="Q9ZC03"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="40"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="273" mass="30267" checksum="272DE1D6AC8C16E0" modified="1999-05-01" version="1">MPKPHETAVYTHGHHESVLRSHTWRTAENSAAYLLGSLRPHMRILDIGCGPGTITADLAERVPEGHVTGVDRSPEIVERARATAAARGLENTGFAVADVHALDYPDDTFCVVHAHQVLQHVGDPVRALREMRRVARPGGFIAVRDSDYGAMTWYPASSGMDDWLDLYHRVARANGGEPDAGRRLKAWALEAGFTDITATSATWTFTTPEEREWWSGLWADRTLASAYAERATEGGHATPERLRAVSAAWRDWGKHPESWFSVLHGEILCRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O54114</accession>
    <name>O54114_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5918</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34590">
        <property type="entry name" value="T34590"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630036.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973102.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5918"/>
    <dbReference type="GeneID" id="1101360"/>
    <dbReference type="KEGG" id="sco:SCO5918"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6016"/>
    <dbReference type="eggNOG" id="ENOG5034769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2275908_0_0_11"/>
    <dbReference type="OMA" id="FTCRTLP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="103" mass="11264" checksum="7DA5C7FD29BA78DA" modified="1998-06-01" version="1">MRCVIARFPFDLTKSGVLESMKGVKPEPVTGESVIIGRRHYPAKQVGQVITRQDRRDFSTGEILRAMAQLGFTCRTLPEAAPARSDSPLQRASAMLGAPHLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O54147</accession>
    <name>O54147_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5884</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34910">
        <property type="entry name" value="T34910"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630005.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973137.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5884"/>
    <dbReference type="GeneID" id="1101326"/>
    <dbReference type="KEGG" id="sco:SCO5884"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5983"/>
    <dbReference type="eggNOG" id="ENOG5032WFI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881888_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045780">
        <property type="entry name" value="DUF6206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19709">
        <property type="entry name" value="DUF6206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="34118" checksum="88F025DB306FAD76" modified="1998-06-01" version="1">MTFSIPADALDALEDEVVRALRTTDDRALTILGYGEVTLVLRLETDAGTFACKRLPVFPSRERLDRHSALVDDYVTRLDKGGVAVAETRMWHRRLPGGRAVAYCVQEALPEGRLCSRLLHTAGEAWCEGFFARFLDRVEATVTPRLGLDGQASNWIDVDGELVYLDVTTPLIRDERERELLDVPLFFTSLPWLVRDVVRMAMTKSIFDKFYTPRGVVLDFLGNLHKERLDHLVPRFLEQANARLDRPLDAEEVGAYYRDDARMWELIQRLRKADRFVHNKILRRPYPFLLPRHVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O69863</accession>
    <name>O69863_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6033</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34713">
        <property type="entry name" value="T34713"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630144.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030607.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6033"/>
    <dbReference type="GeneID" id="1101474"/>
    <dbReference type="KEGG" id="sco:SCO6033"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6133"/>
    <dbReference type="eggNOG" id="COG5285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036343_0_0_11"/>
    <dbReference type="InParanoid" id="O69863"/>
    <dbReference type="OMA" id="FAHWQTY"/>
    <dbReference type="PhylomeDB" id="O69863"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="364" mass="41472" checksum="870722B4472863B2" modified="1998-08-01" version="1">MATPDSYLHRAPSDLPYFSADADTYLARTQLRDLDKTRPLRVLSEEDFAHWQTYGYVVVKEAIPADSARRLLDFAWEFQGLDPERPDTWYQDREYRSDLDRELHIYGFVEAYHHQLIWDSRQTQRVYDAFVDVWDCEELWVTLDRLNLNPPNTGNRDRALINKPDRGFDIDLHWDVDTTLGVLPQRVQGIIALNDTKPDHGGFQCCPELFRRFDRWKALQPDGRDPIRPAIDREDMPVVRPDLEAGDLLIWNGLLAHGVAPNVSGEGVRAVQYLSMMPALESHRTLRDSRVDSWRTLATPDWNATLLGDAHRHESERYGPAELTDLGAKLLGLKPWHADADAGSGDQNSDRNEATGDGACAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>O69894</accession>
    <name>O69894_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5606</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34791">
        <property type="entry name" value="T34791"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629740.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030332.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5606"/>
    <dbReference type="GeneID" id="1101047"/>
    <dbReference type="KEGG" id="sco:SCO5606"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5698"/>
    <dbReference type="eggNOG" id="ENOG5031VAZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2358395_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA19398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="96" mass="10928" checksum="352062514F88EF03" modified="1998-08-01" version="1">MTTRYPALPQSYAITRDRDTVIPRYLVVTALRGGQMAGLSIRVYKIVGETGETEEVSAREWSVDQMPNLPLIDTRWPLCLCWKCNGNGTKGELRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O69917</accession>
    <name>O69917_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6385</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34879">
        <property type="entry name" value="T34879"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630476.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030882.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6385"/>
    <dbReference type="TCDB" id="2.A.3.14.2">
        <property type="family name" value="the amino acid-polyamine-organocation (apc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1101826"/>
    <dbReference type="KEGG" id="sco:SCO6385"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6493"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017999_1_1_11"/>
    <dbReference type="InParanoid" id="O69917"/>
    <dbReference type="OMA" id="FYAIGVF"/>
    <dbReference type="PhylomeDB" id="O69917"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="644" mass="69102" checksum="687070C96C3EA65E" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O69994</accession>
    <name>O69994_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA hydrolase with mutT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5817</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA18515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35191">
        <property type="entry name" value="T35191"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030475.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5817"/>
    <dbReference type="GeneID" id="1101259"/>
    <dbReference type="KEGG" id="sco:SCO5817"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5911"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_3_11"/>
    <dbReference type="InParanoid" id="O69994"/>
    <dbReference type="OMA" id="TYGDPKR"/>
    <dbReference type="PhylomeDB" id="O69994"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="31606" checksum="F828C5764C1F8007" modified="1998-08-01" version="1">MAEPRTCPGPPGGEAQVGRKWINGEAVAEGSVYRQADDYDRRMPYDPSAFPPFAVTVDLVVLTVRRHSLCALAVRRGEPPFQGRWALPGGFVRDGEDLAQAAARELAEETGLCVHDPAAPSQDNGAHLEQLATYGDPERDPRMRVVSVAHLALAPDLPAPRAGGDASNARWAPVEELLEQSGYGRAGEAVAPLAFDHAQILADGVERARSKIEYSSLATAFCPPEFTVGELRRVYEAVWSVALDPRNFHRKVTGTPGFLVPTGGTTTRQGGRPAQLFRAGGATLLNPPMLRPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O86514</accession>
    <name>O86514_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5532</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29062">
        <property type="entry name" value="T29062"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629666.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030297.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1100972"/>
    <dbReference type="KEGG" id="sco:SCO5532"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5619"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_23_1_11"/>
    <dbReference type="InParanoid" id="O86514"/>
    <dbReference type="OMA" id="LANMPGH"/>
    <dbReference type="PhylomeDB" id="O86514"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="194" mass="20936" checksum="AB7F927C127A6D3A" modified="1998-11-01" version="1">MGPQEKPRRVRMTPGARRVLAAAERLFYEHGIHAVGVDTIAAEAGVTKKTLYDRFGSKEQIVVEYLAGRDERWRELLAGRLAAAGEGPAARVVAVFEASRAWSELYGAKGCSMINAHAEISDPGHPAYPVITGQKRWMLDLFTGLARDIDAAGADRLARTLVLLHEGALVSHGVGVLPDPFGAALDQVRELLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O86515</accession>
    <name>O86515_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5533</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29063">
        <property type="entry name" value="T29063"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629667.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973463.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5533"/>
    <dbReference type="GeneID" id="1100973"/>
    <dbReference type="KEGG" id="sco:SCO5533"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5620"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_11"/>
    <dbReference type="InParanoid" id="O86515"/>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="PhylomeDB" id="O86515"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="19960" checksum="49BFDA5ADD3670EC" modified="1998-11-01" version="1">MTTTPDLSTLTGDYTVDPAHTTIGFTARHAMVTNVKGKFLDFTGTLHLDGADPSRSTASLDITMDSIDTGSPDRDGHLKSSDFFNTGEYPTMTFRSTKAESLGGDDYRITGDLSILGTTKPLTIDLEFNGAAKDPFGNERVGFEGKAEIKRSEWGLTWNAALETGGVLVSDKIKLNFDISAIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O86545</accession>
    <name>O86545_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6611</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29117">
        <property type="entry name" value="T29117"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630688.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972367.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6611"/>
    <dbReference type="GeneID" id="1102050"/>
    <dbReference type="KEGG" id="sco:SCO6611"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6718"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115408_0_0_11"/>
    <dbReference type="InParanoid" id="O86545"/>
    <dbReference type="OMA" id="VYSHTRW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="186" mass="19874" checksum="A32B4FE734D48FB2" modified="1998-11-01" version="1">MSVQRPAAEQPTTELDARYSSALHPRPGAADVTATEWAEARRRLEAAEIFWVTTVRPGGGPHVTPVIAAWHDGVLYFSTGPGEQKARNLAHDAHCALITGGNSLTEGFDLVVEGEAEPVGDRAVLEEVIAAYEAKYGAHITSADGTFHGIGDAMRRGDAVLFAVAPVTAYGFGRDDGVYSHTRWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O86742</accession>
    <name>O86742_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5657</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35441">
        <property type="entry name" value="T35441"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629787.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030368.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5657"/>
    <dbReference type="GeneID" id="1101096"/>
    <dbReference type="KEGG" id="sco:SCO5657"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5741"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="InParanoid" id="O86742"/>
    <dbReference type="OMA" id="GMKYVTM"/>
    <dbReference type="PhylomeDB" id="O86742"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="51761" checksum="19A32F70C8690C92" modified="1998-11-01" version="1">MSTELRRLRNYIDGEFRDAADGRTTEVVNPATGEAYATAPLSGQADVDAAMAAAAAAFPAWRDLVPAERQKALLKIADAFEERAEELIAAEVENTGKPIGLTRSEEIPPMVDQIRFFAGAARMLEGRGAGEYMEGLTSFVRREPIGVCAQVAPWNYPMMMAVWKFAPALAAGNTVVLKPSDTTPASTALMADIIGSIVPKGVFNVVCGDRDTGRLMVEHETPAMASITGSVRAGMSVAESASKDLKRVHLELGGKAPVVVFEDTDIPKAVEGISEAGYFNAGQDCTAATRVLVHESVHDEFVSALAKAASEIKTGQPDDEDVMYGPLNNPNQLKQVSGFIERLPAHAKVEAGGHRVGDKGYFYAPTVVSGLKQDDEIIQREVFGPVITVQAFRDEDQAVEWANGVEYALASSVWTKDHGRAMRMSKKLDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSGYGFEDYTRIKHVMTSLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O88026</accession>
    <name>O88026_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6670</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35169">
        <property type="entry name" value="T35169"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630745.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031093.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="SMR" id="O88026"/>
    <dbReference type="STRING" id="100226.SCO6670"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1102109"/>
    <dbReference type="KEGG" id="sco:SCO6670"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6776"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_0_1_11"/>
    <dbReference type="OMA" id="EHIYHAA"/>
    <dbReference type="PhylomeDB" id="O88026"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="186"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA19949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="47298" checksum="82E656300130612A" modified="1998-11-01" version="1">MLGGGGFRVPLVYGALLGDRGEGRVSDVVLHDLDPARLTAVTRVLAEQAAGVPDAPTVTATTDLDEALRGADFVFSAIRVGGLQGRADDERVALAEGVLGQETVGAGGIAYGLRTVPVAVDIARRVARLAPDAWVINFTNPAGLVTEAMSRHLGDRAIGICDSPVGLGRRVARVLGADPDRAFVDYVGLNHLGWLRGLRVGGRDELPRLLADPALLGSFEEGRLFGAEWLRSLGAVPNEYLHYYYFNRETVRAYQEAGLTRGAFLRDQQARFYDEMRRPDAPALATWDRTRAEREATYMAENRETAGAGEREAEDLSGGYEKVALALMRAVARDERATLILNVRNRGTLSVLDADAVIEVPCLVDANGAHPMAVDPLPDHATGLVRAVKGVERDVLAAAGTGSRAAAVRAFALHPLVDSVDVARRLVDGYRAVHPGLAYLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>P0A4E1</accession>
    <accession>P40184</accession>
    <name>GLK_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Glucokinase</fullName>
            <ecNumber evidence="5">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glucose kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ORF 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">glkA</name>
        <name evidence="3" type="synonym">glk</name>
        <name type="ordered locus">SCO2126</name>
        <name type="ORF">SC6E10.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Mol. Microbiol." volume="6" first="2833" last="2844">
            <title>The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression.</title>
            <authorList>
                <person name="Angell S."/>
                <person name="Schwarz E."/>
                <person name="Bibb M.J."/>
            </authorList>
            <dbReference type="PubMed" id="1435260"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1992.tb01463.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>POSSIBLE SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">A probable glucose kinase (Probable). Required for glucose repression of many different genes, restores glucose kinase activity in E.coli glk mutants (PubMed:1435260).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Transcribed from its own promoter, as well as another upstream of the preceeding gene (AC P40182). Expressed when grown on glucose or galactose, levels decrease as cells enter stationary phase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="5"/>
    <dbReference type="EMBL" id="X65932">
        <property type="protein sequence ID" value="CAA46727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S26208">
        <property type="entry name" value="S26208"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626383.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976689.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A4E1"/>
    <dbReference type="SMR" id="P0A4E1"/>
    <dbReference type="STRING" id="100226.SCO2126"/>
    <dbReference type="GeneID" id="1097560"/>
    <dbReference type="KEGG" id="sco:SCO2126"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2161"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_0_11"/>
    <dbReference type="InParanoid" id="P0A4E1"/>
    <dbReference type="OMA" id="APNIDWR"/>
    <dbReference type="PhylomeDB" id="P0A4E1"/>
    <dbReference type="BRENDA" id="2.7.1.2">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000095677" description="Glucokinase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="6"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A6V8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1435260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="1435260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="1435260"/>
        </source>
    </evidence>
    <sequence length="317" mass="33062" checksum="6E65A97691BA15BF" modified="2005-03-15" version="1">MGLTIGVDIGGTKIAAGVVDEEGNILSTHKVPTPTTPEAIVDAIASAVEGARVGHEIVAVGIGAAGYVNRQRSTVYFAPNIDWRQEPLKEKVEARVGLPVVVENDANAAAWGEYKFGGGKGHRNVICITLGTGLGGGIIIGNKLRRGHFGVAAEFGHIRMVPDGLLCGCGSQGCWEQYASGRALVRYAKQRANATPERAEVLLALGDGTPDGIEGKHISVAARQGCPVAVDSYRELARWAGAGLADLASLFDPSAFIVGGGLSDEGDLVLDPIRKSYKRWLVGGNWRPVADVIAAQLGNKAGLVGAADLAREPDPIM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>P40182</accession>
    <name>Y2127_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO2127</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO2127</name>
        <name type="ORF">SC6E10.21c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Mol. Microbiol." volume="6" first="2833" last="2844">
            <title>The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression.</title>
            <authorList>
                <person name="Angell S."/>
                <person name="Schwarz E."/>
                <person name="Bibb M.J."/>
            </authorList>
            <dbReference type="PubMed" id="1435260"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1992.tb01463.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>POSSIBLE FUNCTION</scope>
        <scope>POSSIBLE SUBUNIT</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in glucose transport or metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">It may form a heterotetramer of two glucokinase subunits (glk) with two ORF2 proteins.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Transcribed at low levels from its own promoter. Transcript includes downstream gene glk. Expressed when grown on glucose or galactose, levels decrease as cells enter stationary phase.</text>
    </comment>
    <dbReference type="EMBL" id="X65932">
        <property type="protein sequence ID" value="CAA46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35508">
        <property type="entry name" value="T35508"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626384.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028152.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40182"/>
    <dbReference type="SMR" id="P40182"/>
    <dbReference type="STRING" id="100226.SCO2127"/>
    <dbReference type="GeneID" id="1097561"/>
    <dbReference type="KEGG" id="sco:SCO2127"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2162"/>
    <dbReference type="eggNOG" id="ENOG50340VK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120031_0_0_11"/>
    <dbReference type="OMA" id="GQESRWT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035183">
        <property type="entry name" value="DUF5304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17230">
        <property type="entry name" value="DUF5304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0313">Glucose metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000205345" description="Uncharacterized protein SCO2127">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1435260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="1435260"/>
        </source>
    </evidence>
    <sequence length="191" mass="20131" checksum="7CF36B2A7AC20044" modified="1995-02-01" version="1">MSEELPPSEAPRPDEADAVDETRATGETRGAAQEPGASDADAWATACAEDLEAEKARRRAAYGPPPGSAAEELRRLVDTVADKLSGLQSPLLGQVAGPAAQQVVRQVVQQAKAAVEPVIERNPDLFDHLAAAGGELLAAYRSAVQNQERRWTTGDTAPKDPSDPRDLDERGTDGRDEGDGGTGPGQRIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKK1</accession>
    <name>Q7AKK1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4114</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC1184">
        <property type="entry name" value="JC1184"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628293.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974859.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4114"/>
    <dbReference type="GeneID" id="1099551"/>
    <dbReference type="KEGG" id="sco:SCO4114"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4174"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029927_4_1_11"/>
    <dbReference type="OMA" id="GWMAFDT"/>
    <dbReference type="PhylomeDB" id="Q7AKK1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="473" mass="50821" checksum="00D157434323C123" modified="2012-05-16" version="1">MSREQRGPNEKLGAVLALAGISNAGLARRVNDLGAQRGLTLRYDKTSVARWVSKGMVPQGAAPHLIAAAIGQKLGRPVPLHEIGLADADPAPEVGLAFPRDVGQAVRSATELYRLDLAGRRTGGGIWQSLAGSFAVSAYATPASRWLITPADSSVAREVSPAEGSGAPLKVGHSDVQKLREAAEDARRWDSKYGGGDWRSSMVPECLRVEAAPLLLGSYSDEVGRALFGASAELTRLAGWMAFDTGQQEAAQRYYIQALRLARAAADVPLGGYVLASMSLQATYRGFGDEGVDLAQAALERNRGLATARTMSFFRLVEARAHARAGDAVAAGAALKAAESWLERARPGDSDPTWLGFYSYDRFAADAAECYRDLKAPRQVRRFTEQALSKPTEEFVRSHGLRLVVSAVAELESGNLDAACEQGVRAVEVAGRISSARTTEYVKDLLHRLEPYGDEPRVVELRERARPLLVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKS0</accession>
    <name>Q7AKS0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">SCO0666</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T42027">
        <property type="entry name" value="T42027"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624975.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978196.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0666"/>
    <dbReference type="GeneID" id="1096089"/>
    <dbReference type="KEGG" id="sco:SCO0666"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.650"/>
    <dbReference type="eggNOG" id="COG0753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_3_0_11"/>
    <dbReference type="InParanoid" id="Q7AKS0"/>
    <dbReference type="OMA" id="VMWQMSD"/>
    <dbReference type="PhylomeDB" id="Q7AKS0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="84"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAB61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="759" mass="81283" checksum="291CF8AC671B993C" modified="2012-05-16" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API0</accession>
    <name>Q7API0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding protein, MmyK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mmyK</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639846.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039538.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095319"/>
    <dbReference type="KEGG" id="sco:SCP1.236"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8183"/>
    <dbReference type="HOGENOM" id="CLU_088590_0_0_11"/>
    <dbReference type="OMA" id="HATANYD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="8"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="206" mass="23015" checksum="C0931DFAF397B2CE" modified="2012-05-16" version="1">MTLNRPMRIAVVGAYGNGKTTLTTELSRRLGLPRTHGAAMRDPAGGSGKSLEECTDPELIQLAVRRFTERVVDEARCSRGFVSDGSVLHEWIYTKVRLVLGRLPGPSARLEPVIRSAATAAYEEVIDQIGLLTQQHAFDTYDLVVHLQADVPLPEGHRPISEHFRRVSDQLLRDTLEAWRIPCHVVTGSVQERVRRCRELVDTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q7DJE7</accession>
    <name>Q7DJE7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Insertion element transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IS468B-ORF</name>
        <name evidence="2" type="synonym">IS468A-ORF</name>
        <name evidence="5" type="ordered locus">SCO0098</name>
        <name evidence="9" type="ordered locus">SCO0567</name>
        <name evidence="6" type="ordered locus">SCO3466</name>
        <name evidence="7" type="ordered locus">SCO3467</name>
        <name evidence="10" type="ordered locus">SCO3539</name>
        <name evidence="8" type="ordered locus">SCO6910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="3104" last="3110">
            <title>A complex insertion sequence cluster at a point of interaction between the linear plasmid SCP1 and the linear chromosome of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Yamasaki M."/>
                <person name="Miyashita K."/>
                <person name="Cullum J."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="10809688"/>
            <dbReference type="DOI" id="10.1128/JB.182.11.3104-3110.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">M145</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2001" name="Mol. Gen. Genet." volume="264" first="634" last="642">
            <title>Integrated structures of the linear plasmid SCP1 in two bidirectional donor strains of Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Yamasaki M."/>
                <person name="Redenbach M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="11212918"/>
            <dbReference type="DOI" id="10.1007/s004380000349"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A634</strain>
            <strain evidence="3">M145</strain>
        </source>
    </reference>
    <reference evidence="5 11" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">A3</strain>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AB032065">
        <property type="protein sequence ID" value="BAA84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB032065">
        <property type="protein sequence ID" value="BAA84088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB042600">
        <property type="protein sequence ID" value="BAB17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB042601">
        <property type="protein sequence ID" value="BAB17793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB61791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC44180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAD55323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36179">
        <property type="entry name" value="T36179"/>
    </dbReference>
    <dbReference type="PIR" id="T36659">
        <property type="entry name" value="T36659"/>
    </dbReference>
    <dbReference type="PIR" id="T36998">
        <property type="entry name" value="T36998"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624443.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624880.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627669.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627670.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630979.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733608.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026846.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0098"/>
    <dbReference type="GeneID" id="1095524"/>
    <dbReference type="GeneID" id="1095990"/>
    <dbReference type="GeneID" id="1098903"/>
    <dbReference type="GeneID" id="1098904"/>
    <dbReference type="GeneID" id="1098975"/>
    <dbReference type="GeneID" id="1102349"/>
    <dbReference type="KEGG" id="sco:SCO0098"/>
    <dbReference type="KEGG" id="sco:SCO0567"/>
    <dbReference type="KEGG" id="sco:SCO3466"/>
    <dbReference type="KEGG" id="sco:SCO3467"/>
    <dbReference type="KEGG" id="sco:SCO3539"/>
    <dbReference type="KEGG" id="sco:SCO6910"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3526"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_0_0_11"/>
    <dbReference type="OMA" id="AERTFAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAA84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAA84088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAB17791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB52912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB92572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC44180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAD55323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="279" mass="31492" checksum="7493C1FF06E86CC7" modified="2004-07-05" version="1">MSERKPYPSDLSDARWALIEPTLTAWRNARLERRPTGKPAQVDLRDVFNAILYLNRTGIPWKYLPHDFPGHGTVYFYYAAWRDEGIFTQLNYDLTALARVKEGRKPEPTASVIDTQSVKTSTNVPLTSQGTDAAKKIVGRKRGILTDTIGLILAVTVTGAGLSENAVGIRLLDQAKRTYPTIVKSWVDTGFKNAVIEHGATLGIDVEVVNRNPEKRGFHVVKRRWVVERSIGWIMMHRRLARDYETLTTSSEAMIHIASIDNLAKRITDETTPTWRGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWC9</accession>
    <name>Q8VWC9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alanine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.25c</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639792.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039599.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095065"/>
    <dbReference type="KEGG" id="sco:SCP2.25c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8320"/>
    <dbReference type="HOGENOM" id="CLU_1585506_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="18444" checksum="E610A1FB1A99E8D3" modified="2002-03-01" version="1">MTEINRRPDADYSRLLDLSVLTTWTMDRQRVHHQDAAAYEEILALFQSALRSEVVDGDGRLSAPMRARKVEKHLRAAVKAARKQEVVMERFRLAVAAHQAHVKALPAQREAKQTRKAGRRAVAAHTAKSLHKSAAAFAPAPAEGTPAVPSTAPAARGINDLFNQRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IZ6</accession>
    <name>Q93IZ6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7524</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631569.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971620.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7524"/>
    <dbReference type="GeneID" id="1102962"/>
    <dbReference type="KEGG" id="sco:SCO7524"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7638"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079860_3_1_11"/>
    <dbReference type="InParanoid" id="Q93IZ6"/>
    <dbReference type="OMA" id="QECGAWR"/>
    <dbReference type="PhylomeDB" id="Q93IZ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="172" mass="19215" checksum="326ADC003546BF24" modified="2001-12-01" version="1">MSTVEETIEIAVPVRTAYDQWTQFECFPRFMTTVKRVEQVRPAVTLWVVGLGPLRREFATEIVDQVPDSHLTWRSLGQRHGHRGEVTFRPGEGEHTSVTVRMSAEPRGLTGVLALVPGAAGRVVRRELAHFKAYVEGHGEASGAWRGTIRDGQVRPEEPEPPRSRVAVWPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J04</accession>
    <name>Q93J04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7515</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631560.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031715.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7515"/>
    <dbReference type="GeneID" id="1102953"/>
    <dbReference type="KEGG" id="sco:SCO7515"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7628"/>
    <dbReference type="eggNOG" id="ENOG5032RVV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123371_0_0_11"/>
    <dbReference type="OMA" id="PYYAFGY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025409">
        <property type="entry name" value="DUF4303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14136">
        <property type="entry name" value="DUF4303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="189" mass="20601" checksum="1221CA2FAC5633CA" modified="2001-12-01" version="1">MQPTESELADAVHRAARAALLDLFRVHPDHRFYYCTLVTSGEGYGPALSAWSAEALAAESERQGCAPLDLKWSYADSPFCCYGEAHLEPVRPLFEARGDLFDLPDDAADAEFELRPRAMETAVARLDAEGVFGTGADRHRVVATVEVPSEDGNDERTLRLNPPEAPTDWAVETGADVVRPAPTDAPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF2</accession>
    <name>Q93JF2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="5" type="ordered locus">SCO5975</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630091.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030577.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5975"/>
    <dbReference type="GeneID" id="1101417"/>
    <dbReference type="KEGG" id="sco:SCO5975"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6074"/>
    <dbReference type="eggNOG" id="COG2235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052662_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JF2"/>
    <dbReference type="OMA" id="SAWIYDG"/>
    <dbReference type="PhylomeDB" id="Q93JF2"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC44589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="418" mass="46592" checksum="4AF40C49EA5C0CB7" modified="2001-12-01" version="1">MNGRRSGQDGDMGFQVDSEAGRLTRVILHRPDLELKRLTPSNKDALLFDDVLWVRRARAEHDGFADVLRDRGVAVHLFGDLLTETLDVPAARRLVLDRVFDEKEYGVLATDHLRAAFETLPAHELAEWLVGGMTKREFLDAHPEPTSVRFHAMELDDFLLGPLPNHLFTRDTSAWIYDGVSINAMRWPARQRETVHFEAIYRHHPLFRDESFHLWSEGQADYPSTIEGGDVLVIGNGAVLIGMSERTTPQAVEMLAHKLFAAGSARTIVALDMPKRRAFMHLDTVMTMVDGDTFTQYAGLGMLRSYTIEPGAGEKDLKVTDHPPEHMHRAMAAALGLGEIRVLTATQDVHAAEREQWDDGCNVLAVEPGVVVAYERNATTNTHLRKQGIEVIEIPGSELGRGRGGPRCMSCPVERGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JI0</accession>
    <name>Q93JI0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1982</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626244.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976837.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1982"/>
    <dbReference type="GeneID" id="1097416"/>
    <dbReference type="KEGG" id="sco:SCO1982"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2008"/>
    <dbReference type="eggNOG" id="ENOG5031SQ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_204696_0_0_11"/>
    <dbReference type="OMA" id="MFLVIVR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="60" mass="6491" checksum="5021B2EFB17E2C29" modified="2001-12-01" version="1">MNGRTVLERFPAGGPRGSWPAEEFAQARRLEGMPAEVVMDLATDMFLVVVRRDTAGDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q99PY5</accession>
    <name>Q99PY5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.306</name>
        <name evidence="2" type="ordered locus">SCP1.48c</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
            <plasmid evidence="4">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639623.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639915.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039349.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095127"/>
    <dbReference type="GeneID" id="1095388"/>
    <dbReference type="KEGG" id="sco:SCP1.306"/>
    <dbReference type="KEGG" id="sco:SCP1.48c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7996"/>
    <dbReference type="HOGENOM" id="CLU_1266266_0_0_11"/>
    <dbReference type="OMA" id="IAMGMRM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="218" mass="24686" checksum="F2481958A7B2DABC" modified="2001-06-01" version="1">MTSVLVVVAHPDDAEIAMGMRIHWYALNGATVRVHCLTTGTPAPDGTEVRRQECLSAGELLGVDQYTFSSIPDTRFVENRGRINADLFDVFREARPDIIYTHYPDDQHLDHSVTAREVTTVARREAPNLRHFRSPYSVGFEPNEFFFGTAELLEAKVRALKCFASQTQLDMDVFRQLTEVAYRQHLHHNVVASLPTEATCAEMFNIARQVHVATTRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACT2</accession>
    <name>Q9ACT2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.219</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639827.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039519.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095299"/>
    <dbReference type="KEGG" id="sco:SCP1.219"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8161"/>
    <dbReference type="HOGENOM" id="CLU_097062_2_1_11"/>
    <dbReference type="OMA" id="IVETSTH"/>
    <dbReference type="PhylomeDB" id="Q9ACT2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="173" mass="19021" checksum="208B22A2C4B04914" modified="2001-06-01" version="1">MRRPVNAELDALKGALDHQREHVLGILEGLSEKDLRRPVLPSGWSCLALVRHLTLDVERFWFPGVIAGEPDVTAQLAAGAEAHWYVPEGMGTEEVFADYRAAIARADAVLATATPEQEPAAWPVEIWPAWRLPDVRHILIHVLTEVACHSGHLDATRELIDGTTWLGGNPYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACW3</accession>
    <name>Q9ACW3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.188c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639777.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039487.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095267"/>
    <dbReference type="KEGG" id="sco:SCP1.188c"/>
    <dbReference type="HOGENOM" id="CLU_2384779_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="9873" checksum="99E8493541BCF680" modified="2001-06-01" version="1">MGFMSNPDVLAVLANAPHIALLYVAQACIREVGAIAMLIVVLRGTEAESRPEIIAALGDLRGNRKTVIAQRLARRGRPRKRVGPAGSEGKSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACX6</accession>
    <name>Q9ACX6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.175</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639753.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039474.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095253"/>
    <dbReference type="KEGG" id="sco:SCP1.175"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8121"/>
    <dbReference type="HOGENOM" id="CLU_135445_1_0_11"/>
    <dbReference type="OMA" id="WGLIVDG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="147" mass="14722" checksum="3A3DE4ED1C60C154" modified="2001-06-01" version="1">MIHAAQGLTTRAPGDRGSMSLFMAMSALAILMVLGLLVDGGGALNASNRATSLAQEAARTAGQQLDPAQAVEGTAITIDPEAARAAALDYLAAANVQGDVQITDGGQSLTVTVRDSYTTHFASLLGVGTINVDGTATAHLQTQAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACY2</accession>
    <name>Q9ACY2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCP1.169</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639742.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039468.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095247"/>
    <dbReference type="KEGG" id="sco:SCP1.169"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8115"/>
    <dbReference type="HOGENOM" id="CLU_005379_6_0_11"/>
    <dbReference type="InParanoid" id="Q9ACY2"/>
    <dbReference type="OMA" id="HEELISW"/>
    <dbReference type="PhylomeDB" id="Q9ACY2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="160"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="537" mass="58706" checksum="638B8F89EB02D821" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACZ3</accession>
    <name>Q9ACZ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639731.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039457.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095236"/>
    <dbReference type="KEGG" id="sco:SCP1.158"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8104"/>
    <dbReference type="HOGENOM" id="CLU_564884_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="483" mass="53757" checksum="3B1787A0D586C7E2" modified="2001-06-01" version="1">MQHVSACRHINPVVRLDVSKTALVADTSRHPFGLICDSHAQEIGTTASRRLRRGADFLAAVQFMVGAGYHPKAGRTTVQLAEIFAKRMARSSEGHFPFSAEATARELGLKRRAVYNHARYLRELGLVAYVEHGSKRNVLRTRYGSAWTREHGYRGTATLFAAVAPRMWDEALGRRIEGEGYTARQVGVTDAGRELAIAAAVDKQRRMRSLRQTEPVDNSGQCTPSVVVPQPRSSSSVGGGIKDRTRERACREKSPRHRAKGSTGWSAARTAAAMREARCVQLHTWWTQGSCVRQLAHSLRPFFEAGWSWEEIARELARWTVPLRPRHVASYVSSEIRRRVNTGQLFLPDGLIAPYRQPTTSTWDDNATRHGPRYAAMQALKARTFRPAAARAAAAFEEIRRILGRRAEPGPATTSSVCRVPGARPENVLLSSTEIASLVETHDPVVACETLWAQVDEAAEHRLDTEDRLGSWEYWPPAGPEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD25</accession>
    <name>Q9AD25_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639698.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039424.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095203"/>
    <dbReference type="KEGG" id="sco:SCP1.125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8073"/>
    <dbReference type="HOGENOM" id="CLU_389275_0_0_11"/>
    <dbReference type="OMA" id="ITAGAPW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="724" mass="79705" checksum="F16E675DF39F77A5" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD57</accession>
    <name>Q9AD57_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.93</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639666.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039392.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095171"/>
    <dbReference type="KEGG" id="sco:SCP1.93"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8041"/>
    <dbReference type="HOGENOM" id="CLU_1814685_0_0_11"/>
    <dbReference type="OMA" id="MADDACP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="142" mass="15364" checksum="7B7D7F6D82F0938C" modified="2001-06-01" version="1">MRPRPHERDGRQPQPGDGRPHPHTAGTSAAIRRLGDLLTRMVHEADARIPAGRRARRTLQDMQERIPGYERQPVLVLYRPVMIDEARSPGTALAPVPIAPGAEMQCDRCGGTFGAAPMPTGTQGTRPAPTAWTCDACQALGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-07-24" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADK0</accession>
    <name>MCA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="1">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mca</name>
        <name type="ordered locus">SCO4967</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2008" name="Mol. Microbiol." volume="68" first="861" last="870">
            <title>Mycothiol regulates and is regulated by a thiol-specific antisigma factor RsrA and sigma(R) in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Park J.H."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="18430082"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06191.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="induction">
        <text evidence="2">Transiently induced by thiol-oxidant diamide, under direct control of SigR. Also induced when MSH is oxidized or conjugated.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Loss of amidase activity on mycothiol bimane, leading to dramatically decreased levels of N-acetylcysteinyl bimane. Increased sensitivity to a number of alkylating agents and antibiotics including N-ethylmaleimide and lincomycin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629119.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974009.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ADK0"/>
    <dbReference type="SMR" id="Q9ADK0"/>
    <dbReference type="STRING" id="100226.SCO4967"/>
    <dbReference type="GeneID" id="1100408"/>
    <dbReference type="KEGG" id="sco:SCO4967"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5047"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_2_2_11"/>
    <dbReference type="InParanoid" id="Q9ADK0"/>
    <dbReference type="OMA" id="PLKLYYN"/>
    <dbReference type="PhylomeDB" id="Q9ADK0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000423188" description="Mycothiol S-conjugate amidase">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18430082"/>
        </source>
    </evidence>
    <sequence length="293" mass="33164" checksum="6F5B515F0154B696" modified="2001-06-01" version="1">MTDQLRLMAVHAHPDDESSKGAATMAKYVSEGVDVLVVTCTGGERGSILNPKLQGDAYIEENIHEVRRKEMDEAREILGVGQEWLGFVDSGLPEGDPLPPLPEGCFALEDVDKAAGELVRKIRSFRPQVITTYDENGGYPHPDHIMTHKITMVAFEGAADTEKYPESEYGTAYQPLKVYYNQGFNRPRTEALHHALLDRGLESPYEDWLKRWSEFERKERTLTTHVPCADFFEIRDKALIAHATQIDPEGGWFRVPMEIQKEVWPTEEYELAKSLVETSLPEDDLFAGIRDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADQ1</accession>
    <name>Q9ADQ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative small membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4004</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628186.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029374.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4004"/>
    <dbReference type="GeneID" id="1099440"/>
    <dbReference type="KEGG" id="sco:SCO4004"/>
    <dbReference type="HOGENOM" id="CLU_3048294_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="54" mass="5745" checksum="7626107918556060" modified="2001-06-01" version="1">MDAAGAAVLAVAGAMAVAAFEALVQTGVVMAQRYERGGTRRIGRRSRSRVRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJY8</accession>
    <name>Q9AJY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7740</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631778.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7740"/>
    <dbReference type="GeneID" id="1103178"/>
    <dbReference type="KEGG" id="sco:SCO7740"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7861"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180115_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8494" checksum="4B309CA820F6FFF2" modified="2001-06-01" version="1">MFEIDDVGVFLGLDVGKAAHHGHGLTPAGKKVLDKPLPNSGPELWAVFDKVADDLQQFLEMLEHSLTRFIADGETGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AJZ8</accession>
    <name>Q9AJZ8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7730</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631768.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031865.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7730"/>
    <dbReference type="DNASU" id="1103168"/>
    <dbReference type="GeneID" id="1103168"/>
    <dbReference type="KEGG" id="sco:SCO7730"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7852"/>
    <dbReference type="eggNOG" id="COG2388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132888_0_1_11"/>
    <dbReference type="InParanoid" id="Q9AJZ8"/>
    <dbReference type="OMA" id="QRVFFHT"/>
    <dbReference type="PhylomeDB" id="Q9AJZ8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC22738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="112" mass="12307" checksum="9726A4CFB8A60F64" modified="2001-06-01" version="1">MTESSTPAVVERADADSQYEILVGGQRAGLTAYRDLGAQRVFFHTEIDEAFAGQGLASQLVQQALVDVRASGMRIVPVCPYVAKFLKRHDEFADITDPVTPEVLRWLEAQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK44</accession>
    <name>Q9AK44_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4882</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629035.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974090.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4882"/>
    <dbReference type="GeneID" id="1100323"/>
    <dbReference type="KEGG" id="sco:SCO4882"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4962"/>
    <dbReference type="eggNOG" id="ENOG503293E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040542_0_0_11"/>
    <dbReference type="OMA" id="CDIDPAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="38510" checksum="44E63FB63D3AE377" modified="2001-06-01" version="1">MSPRAGNAGPRTLAFVESPVQLLNVLEWAHTRAPGAELTLVVLSPVDPMTRGQLRRMAELARKEGHEIRWEEARGGATAPFRTVGGLTTPLRQADRIVMGDPFSRYVQLLLTITRAHDLVVVDDGTATMEFVTQLAHGERLVRWHRKGSRPGPRDLLFAPVSRSARHRLTPAPDRQVSVFSSMPIEDVPEGATVTANDFAWTRSRFGPPRITKGADMVGTSLVETGVVDADRYVDAVHALAKTHGAARYFAHRRESAVKLHRLAVETGLQIVRPDLPLELIARRGPIGRTILSFPSTVVHTLPLALAGTDVRVAVCDIDPAWLTESASPRASGFLSGVTGSARDVHRLSAVAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK59</accession>
    <name>Q9AK59_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4058</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628240.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029408.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4058"/>
    <dbReference type="GeneID" id="1099494"/>
    <dbReference type="KEGG" id="sco:SCO4058"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4120"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108923_2_1_11"/>
    <dbReference type="OMA" id="STLVEFW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="18556" checksum="8A59D166AED17162" modified="2001-06-01" version="1">MNESAHSTTEAAELDRIARQIDIDAPADRVWELVARPGWYVNDGAVEADQDVRYEGDTAVVRHPSLGEFRFRTVELDRPRYAAFRWIGTPSRDESAPSTLVEFWIDERDGGGVTLRVVESGFSGLADDPATWLEQREGNDKGWLIELAAAKAYVEQAAPTTPATGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK98</accession>
    <name>Q9AK98_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1364</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625648.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977462.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1364"/>
    <dbReference type="GeneID" id="1096787"/>
    <dbReference type="KEGG" id="sco:SCO1364"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1372"/>
    <dbReference type="eggNOG" id="ENOG50342ZB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099052_0_0_11"/>
    <dbReference type="OMA" id="GLRWQGS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="179" mass="18950" checksum="252F42A88B6827D7" modified="2001-06-01" version="1">MQPRIPRQSAGEQGGRWPDGTDLEDRFGVELTSAVSGARRRAVRDGDRQIDTAHLLHSLLECDADSRELLGDGPRVVRVLGYLVQRSIGYGLRWQSSVEDSGAVPVVTGAAGFSPPAAAAMEDACARAVRRGAARAGGPDLLAALVADPRTRAAEVLARAAVEPHAVLARVESHFEPTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-24" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWJ1</accession>
    <name>DARCH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Darcynin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO7593</name>
        <name type="ORF">SC7H9.05</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the darcynin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631635.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971550.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9EWJ1"/>
    <dbReference type="SMR" id="Q9EWJ1"/>
    <dbReference type="STRING" id="100226.SCO7593"/>
    <dbReference type="GeneID" id="1103031"/>
    <dbReference type="KEGG" id="sco:SCO7593"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7709"/>
    <dbReference type="eggNOG" id="ENOG5031Q68">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165974_0_0_11"/>
    <dbReference type="OMA" id="RETPFWD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031409">
        <property type="entry name" value="Darcynin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17074">
        <property type="entry name" value="Darcynin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220205" description="Darcynin homolog">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="121" mass="13903" checksum="B08A69A99E228C03" modified="2001-03-01" version="1">MPEETAHTPVTAFMLVKTTPEWLALTVEERVHAFTTEVVPVVRARTAGVRSRFYDTEFYSARVTDVWVWEADDHHAYQLLVDALRETPFWDRYFEVVDLLVGTENGYARTYGVDAVTTLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWP6</accession>
    <name>Q9EWP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative AMP-binding ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7681</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631720.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031826.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7681"/>
    <dbReference type="GeneID" id="1103119"/>
    <dbReference type="KEGG" id="sco:SCO7681"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7800"/>
    <dbReference type="eggNOG" id="COG1021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_11"/>
    <dbReference type="InParanoid" id="Q9EWP6"/>
    <dbReference type="OMA" id="PMSPHDE"/>
    <dbReference type="PhylomeDB" id="Q9EWP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="465"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC17498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="553" mass="58573" checksum="8E6321D8501C8E3C" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWQ4</accession>
    <name>Q9EWQ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7673</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971468.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7673"/>
    <dbReference type="GeneID" id="1103111"/>
    <dbReference type="KEGG" id="sco:SCO7673"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7792"/>
    <dbReference type="eggNOG" id="COG4315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053665_0_2_11"/>
    <dbReference type="InParanoid" id="Q9EWQ4"/>
    <dbReference type="OMA" id="GMTVYVY"/>
    <dbReference type="PhylomeDB" id="Q9EWQ4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043448">
        <property type="term" value="P:alkane catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176641" evidence="2">
        <location>
            <begin position="23"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="19107" checksum="9E532A2748AFDE4A" modified="2001-03-01" version="1">MKRIRTATALAAALLVAGAAAGCSDDGGAGSAGGTETRNAADAPDTDVVPAATSSSAPAVDVKDGTYGKSLVDEKGRTLYLFEKDSKDKSKCDDDCAKAWPPFTVKATPTAGKGVKKDLLKTIKRDDGSEQVTYNGHPLYRFADDQKPGDANGQDVDAFGAKWFVVDPDGDKITTKPKTGDGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWT4</accession>
    <name>Q9EWT4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0737</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625041.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0737"/>
    <dbReference type="GeneID" id="1096160"/>
    <dbReference type="KEGG" id="sco:SCO0737"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.727"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="InParanoid" id="Q9EWT4"/>
    <dbReference type="OMA" id="GNHAYSA"/>
    <dbReference type="PhylomeDB" id="Q9EWT4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="27407" checksum="B7139E6111D4193A" modified="2001-03-01" version="1">MTDTRRFTDYAALVTGAARGIGAATARRLATEGARVLLTDVDLVGARRTAAELADDGLDATAFACDVSDRESVETAVAHAVETFGGLDVLVNNAFACTPDAPLFEDEPDDVWARDLDVTLTGAQRCCRAALPHLAASGRGAIVSIGSVNGVQDFGNHAYSAAKAGLASLTRTLAGHAGPRGVRVNLVTPGTVRTTAWEGRDEELAAVRGLYPLGRVGEPEDVAAAVAFLASRDAAWITGTTLAVDGGLTAVNTGFRQAIARAEGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWY0</accession>
    <name>Q9EWY0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1146</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625439.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027608.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1146"/>
    <dbReference type="GeneID" id="1096569"/>
    <dbReference type="KEGG" id="sco:SCO1146"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1143"/>
    <dbReference type="eggNOG" id="COG3786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079606_0_0_11"/>
    <dbReference type="OMA" id="WLHMDHG"/>
    <dbReference type="PhylomeDB" id="Q9EWY0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004325758" evidence="2">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="252" mass="26448" checksum="6D1F860F06BE41C3" modified="2001-03-01" version="1">MARGGGRRTAVAMAALGTLLAGTALSACGGPSGDGGDSRAGESPGEAGRSSASADPTRIPGVGDRLQTRIPGDSRQVVAVYGDGSDSADSTVVLYTKQGSAWHRDRSWAGHNGTKGWTTDHHENDKRSPVGVFTLSDAGGVLPDPEPAPGTGLPYTRSASIAAPRWWAKPYWHDFDYVIAIDYNRVKGTPPNDPTRPEGTSKGGSIWLHMDHGSGTSACVSLPKPAMEYLLRTLDPDQHPVVVMGDRAHLKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-11" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2U7</accession>
    <name>Y4614_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein SCO4614</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4614</name>
        <name type="ORF">SCD39.14c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628776.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974333.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F2U7"/>
    <dbReference type="SMR" id="Q9F2U7"/>
    <dbReference type="STRING" id="100226.SCO4614"/>
    <dbReference type="GeneID" id="1100054"/>
    <dbReference type="KEGG" id="sco:SCO4614"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4686"/>
    <dbReference type="eggNOG" id="COG1666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099839_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2U7"/>
    <dbReference type="OMA" id="SDFDRQE"/>
    <dbReference type="PhylomeDB" id="Q9F2U7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000106202" description="UPF0234 protein SCO4614">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <sequence length="162" mass="17959" checksum="0CF511A91437169E" modified="2001-03-01" version="1">MADSSFDIVSKVERQEVDNALNQAAKEISQRYDFKGVGASISWSGEKILMEANSEDRVTAVLDVFQSKLIKRGISLKALDAGEPQLSGKEYKIFASIEEGISQENAKKVAKLIRDEGPKGVKAQVQGEELRVSSKSRDDLQTVISLLKGQDFDFALQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Z3</accession>
    <name>Q9F2Z3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4354</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628524.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029598.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4354"/>
    <dbReference type="GeneID" id="1099794"/>
    <dbReference type="KEGG" id="sco:SCO4354"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4422"/>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076312_4_1_11"/>
    <dbReference type="InParanoid" id="Q9F2Z3"/>
    <dbReference type="OMA" id="YPGHLNG"/>
    <dbReference type="PhylomeDB" id="Q9F2Z3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="53"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="227" mass="25940" checksum="ED02578A0C5ACC95" modified="2001-03-01" version="1">MRVLPCPDRRAYRCTARLYSSLGQPGRSATMTVLDDRIAMAESDNTRRLDKMFERLERMPVPEGYKVEIVGGVVYMAPQRDIHWQTILEILWALEDHFGRRQARIFSDVRIDFPGYENGFCPDVAKIKSGAKKDDNGKWRYEDVEFVAEVISRGTARNDYEAKKTAYALAEVPVYLIADPYARRCRLFTGPKDGIYVTDTSIEYGGVVDMTHTHLGLTLDTADFPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3G6</accession>
    <name>Q9F3G6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4534</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628697.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029712.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4534"/>
    <dbReference type="GeneID" id="1099974"/>
    <dbReference type="KEGG" id="sco:SCO4534"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4607"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574805_0_0_11"/>
    <dbReference type="OMA" id="SHESDAM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC08350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="474" mass="49217" checksum="2699C0AED46C2202" modified="2001-03-01" version="1">MTRPANHRWAVLDESSDPVPGDPEEVAKLGRQLRKTAEAIEKEAREIKELASVENWKGKAATEFRSAAEGAGDKLRKAFKRYDEAADALGTRVVDGVCSTEFASELHRAQQMADKALRDAEAADADIGAAQKSLDGQPDDTPEDDPDTKKYKEQKENASSALTSAREALHTAKEVRDAAARRAADAIHDVIENDGLKDGWKDKFKNWVHENAGWLTQISKWAGRIALWAGVAALALGWIPVVGQAIAAVANAVALLASVVALATDLVLALGGEGSWKSVILDAVGVATFGLGRAAMAGAKGVAAGGKALARSNLYKSAVASGMKTNKAWNLANRGAQGAIRGKDAAKAMANMPKGKLPTWSNIKEGFSPVSMYRDTVGGVKSISNAFSKQGWREGLGGMAAPRSAGTLDPDLARAAADLDGIAPAATQMPAVSNALGNFSGQTNAWAGATATGVAAGAEGAYGAVTSLYDGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3I6</accession>
    <name>Q9F3I6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sugar binding secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2795</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC10104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627025.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028589.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2795"/>
    <dbReference type="GeneID" id="1098229"/>
    <dbReference type="KEGG" id="sco:SCO2795"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2853"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_2_3_11"/>
    <dbReference type="InParanoid" id="Q9F3I6"/>
    <dbReference type="OMA" id="ACPPWML"/>
    <dbReference type="PhylomeDB" id="Q9F3I6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176684" evidence="1">
        <location>
            <begin position="30"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC10104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="47336" checksum="95EA608A8C831569" modified="2001-03-01" version="1">MRAARRGSARRVVVMAAIASLGAGLLAGCADDGNDEDSSSSGDSSGKTTITLGLFGTMGFKEAGLYDEYEKLNPDINIEENVTERNENYYPALVNHLTTNSGLQDVQAIEVGNIAEVVATQADKFEDMSKAAGVQKANWLDWKWQQATTKDGATIGLGTDIGPMAICYRKDLFEKAGLPTDREEVSKLWAGDWNKFIEAGEKYKKGAGKDTYFMDSPGGLINAILSSEDEKFYDASGKVIYKTNPAVKDAFDLTAEAAEKGLVQSQTQFQPAWDQTISNSLFATVACPPWMLGTIKAKSQPDSAGKWDVAQAPKAGNWGGTFLGVPKSGKHVKEAQKLVTWLTAPEQQAKLFSKMGSFPSAPAAYKLPQVTGGKNDMTGDAPIGELFAKAAEQIPTQVIGPKDQIVQQGLTDNGVILVTQGKSAEDAWDNAVKTIDNNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBK7</accession>
    <name>Q9FBK7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629299.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973826.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5151"/>
    <dbReference type="GeneID" id="1100592"/>
    <dbReference type="KEGG" id="sco:SCO5151"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5234"/>
    <dbReference type="eggNOG" id="ENOG5033S9V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260902_0_0_11"/>
    <dbReference type="OMA" id="FPWYGLD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="26493" checksum="88B6F2B2AA8749D3" modified="2001-03-01" version="1">MRTGRVRPKGGGPFRSDESEEASGHMETTSRAVAQAPAAEGGPQSPSGRRTVDGYLRAPFPWYGLDEAFTGRRWLMQIGTAADGAVEHGSIGHGDEPSVRNEHVAGDEQDAKEKFAVVVTVAANPDRRSADGTGLLEATSVSSAAWLAGVGLLSFTWPGQMDHSLRDDWLEQQTETAWVLADDLDGEDWTTLSLPVDGVPTPFHYRESEFGWVLAGSTEQGVHLGAYGRGMSAYGLAFAVVKDVAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBW0</accession>
    <name>Q9FBW0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631853.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971314.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7825"/>
    <dbReference type="GeneID" id="1103263"/>
    <dbReference type="KEGG" id="sco:SCO7825"/>
    <dbReference type="HOGENOM" id="CLU_2332330_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC03643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="10069" checksum="447DA028418A6DB3" modified="2001-03-01" version="1">MRVSHPEQEVAVRTAGETSYEASLGHRMPAVRCAGLGENGLGPAEHAPAGAGDGRSPSETTNVLEGRTGAACTLRRGRGRRLPRRVPAAAAVTASPLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-20" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC38</accession>
    <name>Y7045_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>UPF0166 protein SCO7045</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO7045</name>
        <name type="ORF">SC4G1.11</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631107.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972099.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FC38"/>
    <dbReference type="SMR" id="Q9FC38"/>
    <dbReference type="STRING" id="100226.SCO7045"/>
    <dbReference type="GeneID" id="1102483"/>
    <dbReference type="KEGG" id="sco:SCO7045"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7149"/>
    <dbReference type="eggNOG" id="COG1993">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146749_0_1_11"/>
    <dbReference type="InParanoid" id="Q9FC38"/>
    <dbReference type="OMA" id="EHWNTLR"/>
    <dbReference type="PhylomeDB" id="Q9FC38"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000185231" description="UPF0166 protein SCO7045">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="114" mass="12495" checksum="2B60BFF8B74A693B" modified="2001-03-01" version="1">MTRLTGSALRLTVYVGENDTWHHRPLYSEIVHRAHAAGLAGASVFRGVEGFGASSIVHTTRLLSLSEDLPVAVVVVDTEERVRGFLPLLDELVTEGLVTLDPCEVVRYEGRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC92</accession>
    <name>Q9FC92_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1221</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977610.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1221"/>
    <dbReference type="GeneID" id="1096644"/>
    <dbReference type="KEGG" id="sco:SCO1221"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1220"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_0_11"/>
    <dbReference type="InParanoid" id="Q9FC92"/>
    <dbReference type="OMA" id="GPSKLHM"/>
    <dbReference type="PhylomeDB" id="Q9FC92"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC01503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="18275" checksum="E39EB3886A1D4D9C" modified="2001-03-01" version="1">MNSRPASFDELDRKIVTALMENARTSFAEIGAEIGLSSTAVKRRVDRLRETDVITGFSATVRPSALGWRTEAYVEVYCEGAAPPRRLAEVVRGYPEITAAMTVTGGADALLHVRARDVEHFEEVLERIRAEPFIRKTISVMVLSHLIPDSPEAGAALLAPKDAADVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCA1</accession>
    <name>Q9FCA1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ordered locus">SCO1212</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625501.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977619.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9FCA1"/>
    <dbReference type="STRING" id="100226.SCO1212"/>
    <dbReference type="GeneID" id="1096635"/>
    <dbReference type="KEGG" id="sco:SCO1212"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1211"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041534_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FCA1"/>
    <dbReference type="OMA" id="WLWDVDY"/>
    <dbReference type="PhylomeDB" id="Q9FCA1"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="65"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="43464" checksum="45C51162FE77761A" modified="2001-03-01" version="1">MAGNSDPLTPRAKIAVTAGKAVAAASRAAGRGSGSVIGGRVALKLDPDLLGRLAGHLDVTLVSATNGKTTTTRLIAEALKAAGPVVSNALGANMPAGITSALAGGADARYGVIEVDEKYLVGVAQATDPKCIALLNLSRDQLDRAAETRMLAENWREGLAGSKAVVVANADDPLVVWAASSSPNVIWVAAGQMWKDDAWSCPSCGGVMQRPGDDWFCGECGFRRPTPSWALSGDHVLDPHGSAWPIHLQLPGRANKANAASSAAVAAVFGVPPQVALERMYQVQAVAGRYDVVQFQGRDLRLLLAKNPAGWLETFSLIDPPPAPVILSVNARGADGTDTSWLWDVDYTRLSGHPICVVGDRKLDLAVRLEVANQQFQVCEDLDQAVQLCPPGRIEVIANYTAFQDLRRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Q2</accession>
    <name>Q9K3Q2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1096</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625390.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027571.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1096"/>
    <dbReference type="GeneID" id="1096519"/>
    <dbReference type="KEGG" id="sco:SCO1096"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1093"/>
    <dbReference type="HOGENOM" id="CLU_2865739_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="64" mass="6661" checksum="0BE070FC34AEA082" modified="2000-10-01" version="1">MWTRAGDVVLDATGQDDLVVLALLGRLYPENVVLRPAGRSAVPTPSGGSGPSRLVTLVDPPQAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3R6</accession>
    <name>ISPE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">SCO3148</name>
        <name type="ORF">SCE66.27c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB95941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627365.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028794.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K3R6"/>
    <dbReference type="SMR" id="Q9K3R6"/>
    <dbReference type="STRING" id="100226.SCO3148"/>
    <dbReference type="GeneID" id="1098582"/>
    <dbReference type="KEGG" id="sco:SCO3148"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3209"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K3R6"/>
    <dbReference type="OMA" id="ACDALWG"/>
    <dbReference type="PhylomeDB" id="Q9K3R6"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189272" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="299" mass="29814" checksum="8BE62BD0B04890D0" modified="2000-10-01" version="1">MSVTVRVPAKVNVQLAVGAARPDGFHDLANVFLAVSLYDEVTATPAADGLRVTCEGPDAGQVPLDRTNLAARAAEALAARYGRAPDVHLHIAKDIPVAGGMAGGSADGAGALLACDALWGTGASREELLEICAGLGSDVPFSLVGGAALGTGRGERLAELEVGGDFHWVFALAARGLSTPAVFREFDRLGEGLDLPEPVADQAVLDALAKGDAAALAVAVTNDLQPAALSLFPELSDTLAAGRAAGALAALVSGSGPTTAFLATDARSASDIAGVLRASGTCRDVRTAVGAAAGATVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4A2</accession>
    <name>Q9K4A2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5219</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629366.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5219"/>
    <dbReference type="GeneID" id="1100660"/>
    <dbReference type="KEGG" id="sco:SCO5219"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5303"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637654_0_0_11"/>
    <dbReference type="OMA" id="LMHDIGQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="418" mass="42419" checksum="24A6857D5AB8B857" modified="2000-10-01" version="1">MQPPARSSPPAAVLLVPGCAGLLALGCLASVLGAGPAQRPVALAFGGLVVLGELTRRTGAEAREAAPLGAAGALAYALLGDVAGQPAHHGVAETVTVVLAASLLGSVPYVARGSGPVLDHLARRVLTVGFAAVCFRPLSNQGVFDDWSGPAYALLLLGLLALTTLCDAVLAAAPAHARTGWPFGPLLREELRGMVGITSAVCATGAVMALAVSVAGLWALPVFSVPLLLAQLSYRRYAAVRATYRQTIASLARATEIAGYTPAGHARRVAGLGVAVGRDLGLSGAELTVLEYAALMHDIGQLSLVDPVPAGATAGLPVTEQRRIALLGGAVVRQTGVDAAVAVVVERQADPCREQPVAARIVRVVNAYDEKARDAGPGGVLTALEELRLATAGDYAPEVVEALARVLSRGSLTEPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4A5</accession>
    <name>Q9K4A5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5214</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629361.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030116.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5214"/>
    <dbReference type="GeneID" id="1100655"/>
    <dbReference type="KEGG" id="sco:SCO5214"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5298"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_11"/>
    <dbReference type="InParanoid" id="Q9K4A5"/>
    <dbReference type="OMA" id="WVTCSVI"/>
    <dbReference type="PhylomeDB" id="Q9K4A5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB94599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="30779" checksum="200771F4921FC932" modified="2000-10-01" version="1">MCGRYAASRRPEDLAGIFEIEKWEPKESLEPDYNVAPTKEVYAVLDRPLKDVEDPEPVRQLRKLKWGLVPSWSKTPEGGARMINARAETVHEKPSYRRAFSTRRCILPADGYYEWVTGKQERDLEVEGRKKRPRKQPYFVTPADGSVFAMAGLYEFWRDRTLPDDHPQAWWVTCSVITTEAETTPLAVAPADGPHALADIHPRMPLMLTPDRWDDWLDPARTDPDELTSLLAPPPTGLMRAFPVSTAVSNVRNNGPELLEELEAPEEGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4B3</accession>
    <name>Q9K4B3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5205</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629352.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030113.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5205"/>
    <dbReference type="GeneID" id="1100646"/>
    <dbReference type="KEGG" id="sco:SCO5205"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5289"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032811_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4B3"/>
    <dbReference type="OMA" id="CEEWYER"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="607" mass="65354" checksum="CF7E79095A078F5F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4J6</accession>
    <name>Q9K4J6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7318</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB93756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631373.1">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="100226.SCO7318"/>
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        <property type="family name" value="the aromatic acid exporter (arae) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1102756"/>
    <dbReference type="KEGG" id="sco:SCO7318"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7421"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_018438_0_0_11"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
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        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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        </location>
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        </location>
    </feature>
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            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
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            <begin position="444"/>
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        </location>
    </feature>
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        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
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        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="752" mass="79640" checksum="B474F6C51D673179" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY86</accession>
    <name>Q9KY86_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5016</name>
    </gene>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
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                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB92609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO5016"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5094"/>
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    </dbReference>
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        <location>
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            <end position="38"/>
        </location>
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            <end position="271"/>
        </location>
    </feature>
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            <end position="117"/>
        </location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="27631" checksum="94D883A8E5E74C1F" modified="2000-10-01" version="1">MGEVAAVVSAITAVAGLLLAVFGIPLVGNSSPIGRSVADSGPTSGAAPAASHSTADAGSEGASASASASASASASGSSKVPSSTAPSGSAPTGQPPAGGDEPRSSASASSCSSSLPQGWRRVEVPALTVCFGRPGGWGEKPAGELQSSWGSPDGVYDLTVKRDRTYGTTARAASAGQLAWYRDTSESSMAGVEVTTHKTRQNGRDALWLEIDYHWEKQSAPRKRLEVFVAGKAGYVYQLLVDTEATSQRLAEQSRLFASARKNLLIDVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI6</accession>
    <name>Q9KYI6_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative luxR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2686</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAB92252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2686"/>
    <dbReference type="GeneID" id="1098120"/>
    <dbReference type="KEGG" id="sco:SCO2686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2742"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056943_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KYI6"/>
    <dbReference type="OMA" id="HGPTLAY"/>
    <dbReference type="PhylomeDB" id="Q9KYI6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="254"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="338" mass="36777" checksum="CD5604FCD4336066" modified="2000-10-01" version="1">MCVKLDIPNNIQVLEICQKGLHFYARILKGRSINQEIPECLTSLGLLRRAPDGGVVAIPPGLAAGGIVRPLEAAIGRQQHALDAVHASIHRAEQVYRDSYREDGVQAARVISGADVISTTLASAVDSCQEELLTAQPGGGRPQELLAKALASDLPALRRGVRQRTIYQHTIRTHNPTLFYVEQISAAGAEVRTLDEVFDRIIVCDQRIAFVPDPGERRSQTALAIEHPGLIRYLVGMFEHAWERATPLRYSPGAHRPPLLADETRRSVLQLMVNGYTDEAIAGRLGMSVRTVATHVRKASEAFGSRSRAQLAFLIAKTGVLDEGPVRADDNPSALAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZJ3</accession>
    <name>Q9KZJ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1152</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625444.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027613.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1152"/>
    <dbReference type="GeneID" id="1096575"/>
    <dbReference type="KEGG" id="sco:SCO1152"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1150"/>
    <dbReference type="eggNOG" id="COG4581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017075_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZJ3"/>
    <dbReference type="OMA" id="DEFHFYA"/>
    <dbReference type="PhylomeDB" id="Q9KZJ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="274"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="854" mass="95511" checksum="2546D80FF2037CA7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZM2</accession>
    <name>Q9KZM2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3022</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627244.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975789.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3022"/>
    <dbReference type="GeneID" id="1098455"/>
    <dbReference type="KEGG" id="sco:SCO3022"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3082"/>
    <dbReference type="eggNOG" id="ENOG5033SAQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383598_0_0_11"/>
    <dbReference type="OMA" id="GVTWVRT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="22127" checksum="2DDD67EC2C225B39" modified="2000-10-01" version="1">MPRGRYSLHDPHDHTPLAEEHFQCAPGPSGWRYVSRLTTPTGDHQGSVDLAIDELGRPIRLELHAADWQVRGAAIDGVTWVRTDPTGIHATEGNARAHAFTGTSPAFLVAVARLLRLTPSESATRVRLVALTDPVLAPRTVDQSWALLNREAHATDNDPLTVDEYQVTALDTGEQYAVHIAGDVVLAAPGIELEDLETPPSVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZP6</accession>
    <name>Q9KZP6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1386</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625669.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977440.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1386"/>
    <dbReference type="GeneID" id="1096809"/>
    <dbReference type="GeneID" id="67393490"/>
    <dbReference type="KEGG" id="sco:SCO1386"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1394"/>
    <dbReference type="eggNOG" id="COG3856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135532_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZP6"/>
    <dbReference type="OMA" id="TGFFFNI"/>
    <dbReference type="PhylomeDB" id="Q9KZP6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="11353" checksum="FF2798206BDB68CD" modified="2000-10-01" version="1">MIAVLGLVVGVVAGLLVRPEVPAAVEPYLPIAVVAALDAVFGGLRAMLDGIFDDKVFVVSFLSNVVVAALIVFLGDKLGVGAQLSTGVVVVLGIRIFSNAAAIRRHVFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZQ8</accession>
    <name>Q9KZQ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2895</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627121.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028652.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2895"/>
    <dbReference type="GeneID" id="1098328"/>
    <dbReference type="KEGG" id="sco:SCO2895"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2954"/>
    <dbReference type="eggNOG" id="COG3694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071040_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZQ8"/>
    <dbReference type="OMA" id="WDFNERY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="31083" checksum="0E46A3BA6581D4DF" modified="2000-10-01" version="1">MAEVAEAAEAAEAAEAAEAARTGVRRGRVVEGVRAYGLIAGMWIRSTMAYRTSFALTAFGNFAMTALDFVAILLMFSRVDALGGYSLPEVAFLYGLSGVSFGLADLAIGSMERLGRRVRDGTLDTLLVRPAPVLAQVAADRFALRRLGRVVQGLLVLGYALVVVDIDWTAAKVLLLPVALISGAGIFCAVFVAAGAFQFAAQDASEVANAFTYGGTTMLQYPPTVFALDLVRGATFVLPLAFVNWLPASYVLGRPYPLDLPGWVAFTPPLAAAACCALAGLAWRAGLRSYRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L005</accession>
    <name>Q9L005_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2308</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626556.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028269.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2308"/>
    <dbReference type="GeneID" id="1097742"/>
    <dbReference type="KEGG" id="sco:SCO2308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2345"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9L005"/>
    <dbReference type="OMA" id="AEDQGMM"/>
    <dbReference type="PhylomeDB" id="Q9L005"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="21752" checksum="7E59E89DDAA26868" modified="2000-10-01" version="1">MTDETPRAHPVRVLLAEDQGMMRGALALLLGMEDDIEVVAQVSAGDEIVAAALTHRPDIALLDIELPGLSGLDAAAELRERAPGCRVLILTTFGRPGYLRRAMEAGAAGFLVKDGPVEELAGAIRRVLGGETVVDPALAAAALSAGPSPLTARECDVLRASADGATVADIAGALHLSESTVRNYLSSAIGKTGTRNRAEALRAARGQGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0E7</accession>
    <name>Q9L0E7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4695</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628854.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029821.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4695"/>
    <dbReference type="GeneID" id="1100136"/>
    <dbReference type="KEGG" id="sco:SCO4695"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4766"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094977_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9L0E7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="18977" checksum="B915019A97814814" modified="2000-10-01" version="1">MGAAFAVLGSFREAAHREPTLTGLVDALDASVVRHNSYVARRGDDERFVTVLILNIDDARNEVQAINCGHVPPHLLDADSVITPPLDSGAPLGLAALAAEPATPGRFAFPGGTALLLTTDGLTESRAADGAFYPLDERLAGPGDLPRALNEDAHAYAGKAAPHDDVAILTVRRPHRSCTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0F4</accession>
    <name>Q9L0F4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628847.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974275.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4688"/>
    <dbReference type="GeneID" id="1100129"/>
    <dbReference type="KEGG" id="sco:SCO4688"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4760"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_7_4_11"/>
    <dbReference type="OMA" id="DYPAFTM"/>
    <dbReference type="PhylomeDB" id="Q9L0F4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="118" mass="12823" checksum="92F0FF1F5648494D" modified="2000-10-01" version="1">MTAGTPLGRIDDDDYPAYTMGRAAEMLGTTPAFLRALGEARLITPLRSEGGHRRYSRYQLRIAARAREMVDQGTAIEAACRIIILEDQLEEAQRINEELRSGGAEASGDSSGSGRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0S7</accession>
    <name>Q9L0S7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4517</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628681.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974425.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4517"/>
    <dbReference type="GeneID" id="1099957"/>
    <dbReference type="KEGG" id="sco:SCO4517"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4589"/>
    <dbReference type="eggNOG" id="ENOG5031H1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101797_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB77308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="241" mass="25965" checksum="4DD376E81728FC23" modified="2000-10-01" version="1">MSAVSHGPTDDIERGATAPFHYAFHHDVPDEFVRLPEPTESDGWREAMAELLPGADAEARDAASEGLRRQLPLLSARENVLLTAMCVGTEEVDGGERLSMGLLAVTVRPSEHSPARRLFTAEGIYRATAKKFFSHVAEDRLEEISFPLGEGLQGPQDMVLATKLPCGPGVMSTSLRTLRLPPIEAGIAVPPLPMAALQLIVPAPHGYCVYVTISTPSVFLLDSYSARLAHIARTLGFGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1C1</accession>
    <name>Q9L1C1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76080.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625839.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977263.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1561"/>
    <dbReference type="GeneID" id="1096992"/>
    <dbReference type="KEGG" id="sco:SCO1561"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1573"/>
    <dbReference type="eggNOG" id="ENOG5033GN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140382_0_0_11"/>
    <dbReference type="OMA" id="DWHFIGM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76080.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="12549" checksum="6F2B45F2DD55C4B3" modified="2000-10-01" version="1">MLDVLTLVTGVAALLLAAWCGWAAYRDQPTKDWHFIGMAAVSALALIQLVVGIVQLARGEDPEQGTTIFVAYLLGAFACVPAAGFMSLAERTRWGSVTVAAGGVVLAVLEVRLFDIWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L254</accession>
    <name>Q9L254_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2667</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626902.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028498.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2667"/>
    <dbReference type="GeneID" id="1098101"/>
    <dbReference type="KEGG" id="sco:SCO2667"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2715"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_2_0_11"/>
    <dbReference type="InParanoid" id="Q9L254"/>
    <dbReference type="OMA" id="KVCVACR"/>
    <dbReference type="PhylomeDB" id="Q9L254"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="216"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB71205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="482" mass="49062" checksum="CCBCEE9FF3FD7B91" modified="2000-10-01" version="1">MSQMPQQAAVPKCPSCEEPLESGDRFCGACGYDLSVVPARPEDSPTLAINGAVPAPDGVDWPVARDSDGHGHPAPVHAAAELPGTDSGGSPLPPPPPPPAAPPSTPAPPSAPAAPAAPAAPAGSPASGVRFDRPGEPDEYPLQAPDPRLTAEQAPAAAPAPVPAPAAVPRQPAAPAAAEKVCVACRAGRVDDDGYCENCGHAQPRERDHMEQESGPIAAVSDRGLRHHRNEDAFSVGCTALPDGARAQVAIVCDGVSSATRPDDASLAASRAAGESLLGALPRGTHPQQAMHEAILAASHAVNALADEPATAREQAPHQNAPACTLVGAVVTAGLLVVGWVGDSRVYWVPADRATPPARLTEDDSWAAQMVAAGLMNEAEAYADERAHAITGWLGADAYELEPHTASFKPDRAGVVVVCTDGLWNYAESAEEMAEAMPPDAADRPLHAARVLVGHALDGGGHDNVTVALLPFPAPPQGAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L292</accession>
    <name>Q9L292_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO1517</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625796.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027824.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1517"/>
    <dbReference type="GeneID" id="1096943"/>
    <dbReference type="KEGG" id="sco:SCO1517"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1526"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_4_1_11"/>
    <dbReference type="InParanoid" id="Q9L292"/>
    <dbReference type="OMA" id="YNRIVHG"/>
    <dbReference type="PhylomeDB" id="Q9L292"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176834" evidence="9">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB70919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="17770" checksum="AF1AD41E77AB08A4" modified="2000-10-01" version="1">MSLVTLLPFIVLIGAMFLMTRSAKKKQQQAANMRNEMQPGTGVRTIGGMYATVKEVNDDTVLLDAGPGVELLFAKNSIGAVLSDDEYNSIVHGIEHDLKSDADVVPDDASSLTETDASADDASDDKSVDLGKKAEPADETADEPKADAAPAEAKTDEQAKKSDGGSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2G5</accession>
    <accession>Q7BB69</accession>
    <name>Q9L2G5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ecrA1</name>
        <name evidence="4" type="ordered locus">SCO2518</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="3183" last="3192">
            <title>Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays.</title>
            <authorList>
                <person name="Huang J."/>
                <person name="Lih C.J."/>
                <person name="Pan K.H."/>
                <person name="Cohen S.N."/>
            </authorList>
            <dbReference type="PubMed" id="11731481"/>
            <dbReference type="DOI" id="10.1101/gad.943401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF425991">
        <property type="protein sequence ID" value="AAM78431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626758.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028401.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2518"/>
    <dbReference type="GeneID" id="1097952"/>
    <dbReference type="KEGG" id="sco:SCO2518"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2563"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="OMA" id="DDIAETC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="341"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAM78431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="447" mass="47687" checksum="495CDE5A245378D9" modified="2000-10-01" version="1">MPGVRSAPLPSRRGAFVAEYGRVQATTTATNPRRTARPRRGERIIAAINRDPRTAEHGTRNDTVLAGVLLLGAVCLALFTDDGRRPDALGWTLLVAAHVPIVWRRRHPLLVLAALVAVVAPYHAMDNNHTAVGPASYVALYTLAVTGRPLRTILTGIAVLTVSVSIMLIVDTHQALELIRTSGWVIAILFCGIDVRYYRQYVAAIVERAERAERTREEEARRRVAEERLRVARDLHDLLAHSITLIGVQTSVAAHVLTADPERLDREAVAKALDDIAETCRSARGELRTTLEVLRGQDTAGVPDARGPLPGLSGLPDLAESARLAGADVDLSVRADDVPPAVGAAVYRIAQEALTNAVRHAGPKPSVRVAVHGERGALRLSVTDDGTGPDPAGTPGFGLVGMRERARSVGGTLDAGPRRGAAGFEVTAVLPTPAPTRTAHPTTERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2I1</accession>
    <name>Q9L2I1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2502</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626742.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028390.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2502"/>
    <dbReference type="GeneID" id="1097936"/>
    <dbReference type="KEGG" id="sco:SCO2502"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2547"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q9L2I1"/>
    <dbReference type="OMA" id="WSGFMFA"/>
    <dbReference type="PhylomeDB" id="Q9L2I1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB69723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="477" mass="48552" checksum="E229D94A5349762B" modified="2000-10-01" version="1">MTETITSRPVRTGTPEAPPALGGLGLFTVLLGAALPLVDFFIVNVALPTIGADLSAGEAVLELVVAGYGVAYAVLLVLGGRLGDLLGRRRLFLGGMAAFGLTSLACGLAPDAWSLVAARVAQGASAAAMLPQVLATIQATTTGPRRAKAMSLYGATAGLSMVAGQILGGVLVAADIAGTGWRSVFLVNVPVVLAGLFLAARAVPETRSARPEPVDVPGTFLLAASILTLLVPLTEGRAAGWPLWTWLSLAAFPFAAAAFYAVERRADRAGRTPLVPPSLFAIVSLRRGLLLIVPFSIGFSGFMFVIAVALQQGAGLGPVAAGLALAPLAVVFFLFSLAGPRLVARYGTRVVPTGAVLQGVGLALMTLAAWRSWPDLGLVELLPGAAVAGAGQALQLPVVLRLVLSEVPAERAGVGSGVMVTTQQSSLALGVATLGTLFLSLTPGMGMRDALVTTLLVQLAGVALTGLLSLRLPRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD30</accession>
    <name>Q9RD30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625179.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027412.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096303"/>
    <dbReference type="KEGG" id="sco:SCO0880"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.871"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1854029_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="138" mass="15085" checksum="1F899133A9EB80D1" modified="2000-05-01" version="1">MVLAAPGGTAAVTAAIAAALTQLYLLIWAGKTVAALAGWLLQTRVGVTLAASYLADLLRSRERLVVFGVTRVRRLVSRVRADLDELTDEDRAQIRQAVQVVRRTRQVGSLGLPRVRQPLPDLRRTRSPDMSKGPFNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD56</accession>
    <name>Q9RD56_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0626</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB62755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624937.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027256.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0626"/>
    <dbReference type="GeneID" id="1096049"/>
    <dbReference type="KEGG" id="sco:SCO0626"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.608"/>
    <dbReference type="eggNOG" id="ENOG503364G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320300_0_0_11"/>
    <dbReference type="OMA" id="TPTHENR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="22837" checksum="7BF483217DCF5899" modified="2000-05-01" version="1">MTVKEAPARADLAATDDIGWAVRLLAATPTHEHRDPELLHRWARTADAFGAALAPVECRARIVERDGGLELGLLARYTSRPPTVELYTDTIDLAERVVDARGWRAWYPPGSVRAAALAHEAVHVHLHHGPGKAALKHALGHSALRLGRLRVPGHVAGAEEVAAHAYARTVCGLGRSPLLLTAALAAETETVTVTENGSVTGSTPPPARDARREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDN3</accession>
    <name>Q9RDN3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2404</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626650.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976402.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2404"/>
    <dbReference type="GeneID" id="1097838"/>
    <dbReference type="KEGG" id="sco:SCO2404"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2445"/>
    <dbReference type="eggNOG" id="COG4213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_13_1_11"/>
    <dbReference type="InParanoid" id="Q9RDN3"/>
    <dbReference type="OMA" id="SARWIDD"/>
    <dbReference type="PhylomeDB" id="Q9RDN3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176878" evidence="1">
        <location>
            <begin position="26"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="44"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="369" mass="39625" checksum="F9CB595548C01488" modified="2000-05-01" version="1">MRNRRAALAAIASAASLALTLTACGQSGEGGSEENKSGSDGATVGIAMPTKSSERWITDGANVEKELKAKGFKTKLVFGEDDPDQQVSQIENMITQGVDALIVAAIDNKSLGNVMQQAKDADIPVISYDRLILGTENVDYYASFDNEKVGELQGGYIVDKLGLKAGKKGPFNIELFAGSNDDNNTRYFFNGAMKVLKPYMDKGQLVVRSKQTDLNQVTTLRWDGGTAQKRMDDLLTSSYRSARVDAVLSPYDGISIGILSALKSDGYGSGSKAMPVVTGQDAEIASVKSIKAGQQTQTVFKDLRELAKVAASMVDAVLNDKKPEVNDTKSYDNGSKVVPAYLLQPVSVDKSNWEKILVDGGYYSADKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS5</accession>
    <name>Q9RDS5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2242</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626491.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976571.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2242"/>
    <dbReference type="GeneID" id="1097675"/>
    <dbReference type="KEGG" id="sco:SCO2242"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2280"/>
    <dbReference type="eggNOG" id="COG5500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111152_1_3_11"/>
    <dbReference type="OMA" id="MATWRPE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="16191" checksum="C7212463DF1B1D5C" modified="2000-05-01" version="1">MLNALEVVTTVVVGVMVGVEFAVAFVMNPILNALPEDSRQLGHAHGGRMLGAVMPVWYIGSLVLVAIWAALGRHHHGTGLVVTAGALLILSVVMSILLLVPINNRNKTWTPENRPEDWKEQTQRWLRWHYVRLAVIGAAFALLATALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI75</accession>
    <name>Q9RI75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0102</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37002">
        <property type="entry name" value="T37002"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624445.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026848.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0102"/>
    <dbReference type="GeneID" id="1095527"/>
    <dbReference type="KEGG" id="sco:SCO0102"/>
    <dbReference type="HOGENOM" id="CLU_1757736_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="15576" checksum="1330835830905C16" modified="2000-05-01" version="1">MSDNVAPLVPRSADVERRRYVSSLHSAPQRTGVSHVGSISHGCDVDPVGPDVKPAGKRSAVLRFVLAATPAPTGTSPTRTRVRTSSGRLRLAPGSARRARRDSHAPRLLVGVRERAADDGGEGVRALPEASGLRVCALSAIEQGWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJG6</accession>
    <name>Q9RJG6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0468</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624787.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027140.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0468"/>
    <dbReference type="GeneID" id="1095891"/>
    <dbReference type="KEGG" id="sco:SCO0468"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.446"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJG6"/>
    <dbReference type="OMA" id="RPHPHIN"/>
    <dbReference type="PhylomeDB" id="Q9RJG6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="5">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB56728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="34293" checksum="42FD56904177C180" modified="2000-05-01" version="1">MSNTETHPAEVRCGAGEEGAPAAGVEILTARDVPLGGPRAMTVRRTLPQRARTLIGAWCFADHYGPDEVSRSGGMDVAPHPHIGLQTVSWLFSGEIEHRDSVGSHALVRPGEVNLMTGGHGISHSEVSTPDTTVLHGVQLWVALPSEHRDTAPAFQHHVPAPVALDGGEARVFLGSLAGDTSPVGTFTPLLGAEVTLAPGATVTLDVDPGFEHGVLVDSGDVRLDGTVVRPAELAYAAPGRRTLALTNAASGAARLVVLGGPPFPEEIVMWWNFVGRTHDEIAAARADWENEAERFGRVEGYPGDRLPAPALPNATLSPRRNPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJK3</accession>
    <name>Q9RJK3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO0385</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624707.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027074.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0385"/>
    <dbReference type="GeneID" id="1095808"/>
    <dbReference type="KEGG" id="sco:SCO0385"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.361"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035591_0_0_11"/>
    <dbReference type="OMA" id="TERLPMW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="9">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB58326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="521" mass="55391" checksum="F489BC68961F3800" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJS1</accession>
    <name>Q9RJS1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protei</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0415</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624736.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027097.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0415"/>
    <dbReference type="GeneID" id="1095838"/>
    <dbReference type="KEGG" id="sco:SCO0415"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.391"/>
    <dbReference type="eggNOG" id="ENOG5033WT8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155293_0_0_11"/>
    <dbReference type="OMA" id="VWHASGF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="120" mass="12613" checksum="ECDE94549A316461" modified="2000-05-01" version="1">MATQATAQHRLSFLRIAIALQTLTIFLQAVSAGLLLTASYGETLHSVGARVMYGASMLYVLAAVLAWKPGGGPLRPVRHACGFLVLASVQVVLGIAHVPSVHLPLGVLMFGLSVLALARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK08</accession>
    <name>Q9RK08_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO0498</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36416">
        <property type="entry name" value="T36416"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624815.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027161.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0498"/>
    <dbReference type="GeneID" id="1095921"/>
    <dbReference type="KEGG" id="sco:SCO0498"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.478"/>
    <dbReference type="eggNOG" id="COG3486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020931_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RK08"/>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="PhylomeDB" id="Q9RK08"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB53328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="451" mass="49851" checksum="57160901E0E7CAD6" modified="2000-05-01" version="1">MSQVLPADSTLVHDLIGIGFGPSNVAMAIAIREHNAQAGGQEELDARFFEQQPRFGWHRGMLIDDATMQVSFLKDLVTLRNPASRYSFLCYLQSRGRLIDFINHKNLFPLRVEFHDYFEWAAAKVDDMVSYGHEVVGVAPVVRDGVVDHLEVTVRSGEGLEVHRARNLVVGTGLRPLVPEGVERGDRVWHNSELLSRVDTLEGTSPSRFVVVGAGQSAAENVAYLHRRFPSAEICAVFARYGYSPADDSAFANRIFDPAAVDDYFTAPDGVKQRLMDYHGNTNYSVVDIDLIDDLYRQMYREKVLGTERLRFLNVSRLSDVKETPDRVRATVTSLVTGEESHLDADVVVLATGYGPADPLGLLGEVADRCLRDDEGRVRVERDYRVTTDPALRCGIYLQGGTEHTHGITSSLLSNTAVRVGEILESLLDRGLESASDEVRTVADGTGTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKD6</accession>
    <name>Q9RKD6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627367.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028796.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3151"/>
    <dbReference type="GeneID" id="1098585"/>
    <dbReference type="KEGG" id="sco:SCO3151"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3212"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_3_11"/>
    <dbReference type="InParanoid" id="Q9RKD6"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="PhylomeDB" id="Q9RKD6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="31381" checksum="9407A7D48FFBCE0D" modified="2000-05-01" version="1">MPSNASGRSDKDGAPPLPEPLRVPVADSHTHLDMQSGTVEEALAKAASVGVTTVVQVGCDLAGSRWAAETAAAHDAVHATVALHPNEAPRIVHGDPDGWSRQGAREPGGDAALDDALAEIDRLAALPQVKGVGETGLDYFRTGPEGKEAQERSFRAHIEIAKRHGKTLVIHDRDAHTDVLRVLKEEGAPERTVFHCYSGDAEMAGICARAGYYMSFAGNVTFKNAQNLRDALAVAPPELVLVETDAPFLTPAPYRGRPNAPYLVPVTVRAMAEVRGVDEDTLATALAANTARAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL19</accession>
    <name>Q9RL19_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0298</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB55655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624626.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026999.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0298"/>
    <dbReference type="GeneID" id="1095722"/>
    <dbReference type="KEGG" id="sco:SCO0298"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.272"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_4_11"/>
    <dbReference type="InParanoid" id="Q9RL19"/>
    <dbReference type="OMA" id="WFKRERN"/>
    <dbReference type="PhylomeDB" id="Q9RL19"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="30740" checksum="384E3C84EB441D35" modified="2000-05-01" version="1">MDALEIRELRYFVAVAEELHFGRAAERLGMAQPPLSRAIQQLERRLGVRLLKRNRRGVALTGAGEMLLHEGRAALDATTAAARRTRRAGGADSPGGPRNRLVLAVKAGASHELLHKLLDAYAAEPDAAEIEVLPSGTCEQEGMLRDGRADVALMHAPFNSLAGFDSEELMTEGQIAVLPAGHPLAARRTLSLADVSDIPDLPLARWSRHGTYPPGPGPEIHDQTQLAQLIALGRTVAVYPDSARAWLWAEHAAVPLTDAAPVVTHIAWPAHSSSPALAGLVRTATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL53</accession>
    <name>Q9RL53_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0433</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624754.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027112.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0433"/>
    <dbReference type="GeneID" id="1095856"/>
    <dbReference type="KEGG" id="sco:SCO0433"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.410"/>
    <dbReference type="eggNOG" id="COG1378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056943_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RL53"/>
    <dbReference type="OMA" id="TRMQLAW"/>
    <dbReference type="PhylomeDB" id="Q9RL53"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="334" mass="36423" checksum="B6B9C9F2EFC2E6D4" modified="2000-05-01" version="1">MVLEIAGLSPDEESVYALLVTFGRAGAADLAERDGMPVERMDRVLESLTAKGLASPTDGVPRLYQAAPPDVALLPRLKRSAEALDLAQHEAARLIESYRDTMRRRDAGQLLEVITGAEALRQHLRQIQTSVREEMLWFCKAQYVAMPSGSNTEEFEALARGVRYRVLYEKAFFDDEGAVDNVVAGVRAGEVARAVPQLPLRLAIADRAVAVFPLVAGGPHGSPEEPTTALVRDSNLLAALIALFERYWEDAVPLDVDDSGELSGTDGPAAPDALAPTDRRLLSLLVAGVADKAIASQMQLSRRTVQRRIQGMMERANAATRMQLAWQAARRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1P8</accession>
    <name>Q9S1P8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0243</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37158">
        <property type="entry name" value="T37158"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624575.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026952.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1095667"/>
    <dbReference type="KEGG" id="sco:SCO0243"/>
    <dbReference type="eggNOG" id="ENOG5032VDG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2958656_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="59" mass="6529" checksum="14F2C375A391F9D7" modified="2000-05-01" version="1">MSATVTDEQIRALAATAKPYSLAFLRWGPERTMDGADAIELEHQRRMVSLRAEGVIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1V1</accession>
    <name>Q9S1V1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0041</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37105">
        <property type="entry name" value="T37105"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624399.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026801.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0041"/>
    <dbReference type="GeneID" id="1095474"/>
    <dbReference type="KEGG" id="sco:SCO0041"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.33"/>
    <dbReference type="eggNOG" id="ENOG5033WVN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634444_0_0_11"/>
    <dbReference type="OMA" id="GWWPAAG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="161" mass="16299" checksum="C4A3BE0224A6B55E" modified="2000-05-01" version="1">MTPAVAALLMLAGLSEALGRVTPVAVRRRGVPRSRIVRLVLAGAVVEGAVFALWPLTAWTLAELLPASPSPGDGLDWTPGLVTPLVLSAVLAFPLLGPLLHLLLFVGVGAGLTGPLSAATGLGWWTAAGCVAVAGVALGVTVEGVRRLVVRISVTDTAETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1Y2</accession>
    <name>Q9S1Y2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0012</name>
        <name evidence="3" type="ordered locus">SCO7835</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37074">
        <property type="entry name" value="T37074"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624373.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026775.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0012"/>
    <dbReference type="GeneID" id="1095452"/>
    <dbReference type="GeneID" id="1103273"/>
    <dbReference type="KEGG" id="sco:SCO0012"/>
    <dbReference type="KEGG" id="sco:SCO7835"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.10"/>
    <dbReference type="eggNOG" id="ENOG5032WVP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874204_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC03653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="15516" checksum="73347C910BE7FD28" modified="2000-05-01" version="1">MEACAPWRPISAGEARERDAAGLPHVVVYREPGREAPLEVRLVSRQDHHVGLWAYDAQDRRSHDLDMRLLDDPSRLLRRYSVSWHCTGPETAEFDKAGPRITVDLMQEHQRLHGDVLTGLRAPPEPPPSLRPLPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2Q8</accession>
    <name>Q9S2Q8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative endo alpha-1,4 polygalactosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2178</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35294">
        <property type="entry name" value="T35294"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626431.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028181.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1097611"/>
    <dbReference type="KEGG" id="sco:SCO2178"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2215"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051214_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S2Q8"/>
    <dbReference type="OMA" id="STGAWED"/>
    <dbReference type="PhylomeDB" id="Q9S2Q8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176977" evidence="2">
        <location>
            <begin position="22"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="3">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="30789" checksum="BEECFE1743703A33" modified="2000-05-01" version="1">MRRPVLPTALLLLLLAGCTSAPGGDGGVGGVGGEGGEGGEGGDGGVGATAGHWRPTPGTAWQWQLSGRLDTSVDVPVYDIDGFDHDEATVAGLHDDGRKVICYVSTGAWEDFRPDADAFPKKVLGKGNGWEGERWLDIRATDVLEPLMAERLDMCRDKGFDAVEPDNMDGYKNDTGFPLTGDDQLRYNRLIAKLAHDRGMAVGLKNDLDQIPDLVDDFDFAVNEQCAQYGECADNRPFVDADKAVFHVEYELPTERFCADSRELRLSSMLKKYELDAWREAC</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX08</accession>
    <name>Q9WX08_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36274">
        <property type="entry name" value="T36274"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627536.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975510.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3326"/>
    <dbReference type="GeneID" id="1098760"/>
    <dbReference type="KEGG" id="sco:SCO3326"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3386"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_2_11"/>
    <dbReference type="InParanoid" id="Q9WX08"/>
    <dbReference type="OMA" id="MQLLGAC"/>
    <dbReference type="PhylomeDB" id="Q9WX08"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="353" mass="37515" checksum="40CA97D45FED47FD" modified="1999-11-01" version="1">MGKVVLVTGVARQLGGRFVRRVQRDPGVERVIGVDAVAPEHHLGGAEFVQADIRQSAIGRVLAQTRADTVVHLDVTGTPLGSGSRASVKETNVIGTMQLLGACQKSPTVRRLVVKSSTNVYGSAPRDPAVCVETTAPKSLPSGGFAKDAVEVEGYVRGFARRRPDVSVTVLRFANILGPAADTPLASYFGLPVLPTVFGYDPRLQFVHEDDVIEVLRVCADEPRRGTLNSGTFNIAGDGVLLLSQCSRRLGRPTVPLLLPAVTWAGSLVRTLGMTDFSPEQIRLLTHGRVVDTTQMRETLGFRPKYSTAGAFADFAHGRGAGLLPPEALAGAVDRIAELSLRGSGHLPTQSAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X827</accession>
    <name>MURC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">SCO6060</name>
        <name type="ORF">SC9B1.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41553.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35852">
        <property type="entry name" value="T35852"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630169.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030625.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X827"/>
    <dbReference type="SMR" id="Q9X827"/>
    <dbReference type="STRING" id="100226.SCO6060"/>
    <dbReference type="GeneID" id="1101501"/>
    <dbReference type="KEGG" id="sco:SCO6060"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6161"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_11"/>
    <dbReference type="InParanoid" id="Q9X827"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="PhylomeDB" id="Q9X827"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182164" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="462" mass="47634" checksum="7E6A17CBC5488702" modified="1999-11-01" version="1">MAPGLPTAMDRPHFIGIGGAGMSGIAKILAQRGAEVAGSDAKESATADALRALGATVHIGHAAEHLAADASCVVVSSAIREDNPELVRAAELGIPVVHRSDALAALMNGLRPIAVAGTHGKTTTTSMLAVSLSELDLGPSYAIGGDLDAPGSNALHGEGEIFVAEADESDRSFHKYAPEVAIVLNVELDHHANYASMDEIYESFETFAGKIVPGGTLVIAADHEGARELTRRLAGRVRTVTYGESEDADVRILSVVPQGLKSEVTVVLDGAELTFAVSVPGRHYAHNAVAALAAGAALGVPAAELAPALAAYTGVKRRLQLKGEAAGVQVVDSYAHHPTEMTADLEAMRAAVGDARILVLFQPHLFSRTQELGKEMGQALALADASVVLDIYPAREDPIPGVTSELIVEAARAAGADVTPVHDKDASPALVAGMAKAGDLVLTMGAGDVTDLGPRILDELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X828</accession>
    <name>Q9X828_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6061</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35853">
        <property type="entry name" value="T35853"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630170.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972860.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6061"/>
    <dbReference type="GeneID" id="1101502"/>
    <dbReference type="KEGG" id="sco:SCO6061"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6162"/>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_11"/>
    <dbReference type="InParanoid" id="Q9X828"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="PhylomeDB" id="Q9X828"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB41554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="135" mass="15152" checksum="4322D9FF139C1F9A" modified="1999-11-01" version="1">MSYDVEKPDEQWRAELAPAEYAVLREAATEPAFTGEYTDTKTEGVYSCRACGAELFTSTTKFESHCGWPSFYDPRDTDAVELIEDRSHGMVRTEVRCARCGSHLGHVFKGEGYPTPTDQRYCINSISLRLEPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8C5</accession>
    <name>Q9X8C5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replication initiator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3252</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB40310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36212">
        <property type="entry name" value="T36212"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028860.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3252"/>
    <dbReference type="GeneID" id="1098686"/>
    <dbReference type="KEGG" id="sco:SCO3252"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3316"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041009_0_0_11"/>
    <dbReference type="OMA" id="FGGHFLT"/>
    <dbReference type="PhylomeDB" id="Q9X8C5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB40310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="466" mass="51089" checksum="B2CC5B77EBEA4E99" modified="1999-11-01" version="1">MAHRAPTAHAPLLDPTTLGDVLRVASAPDYTRWEDQVRRTGGCSDPIHLTGWTLHKDKTTGETLHHYTTAVEPGGRLRLACGNRRASRCPSCAWTYAGDTYHLVRAGLAGDDRRDVPATVRDHPRVFATLTAPSFGAVHNRPDHGACRCGTQHSPDAPELGTALDPATYDYAGAVLFNNHAGQLWQRFTTRLRRELAARAGLTRRELADRVRVSYGKVAEFQKRGALHFHAVIRLDGPDGPGTPPPAWATVGLLADAIHAAAAHSYTSVSVPAAGDQPARSFRWGTQLDVRPVKAFGDGSDTTEQAVVSYVAKYSTKAAENTGTLDRRIGELAELDRHQVPDHTRRLITACRDLDRLYPDRRLWAWAHMLGFRGHFSSKSRRYSTTLGALRQARADYRATQEHTALALDDREPDTVLVLTDWQYAGHGHTPGESALAATIARDLQLNRETAREALQDQLALEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8J5</accession>
    <name>Q9X8J5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3416</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36342">
        <property type="entry name" value="T36342"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627622.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028961.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3416"/>
    <dbReference type="GeneID" id="1098853"/>
    <dbReference type="KEGG" id="sco:SCO3416"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3479"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019582_2_1_11"/>
    <dbReference type="InParanoid" id="Q9X8J5"/>
    <dbReference type="OMA" id="TMAPHSE"/>
    <dbReference type="PhylomeDB" id="Q9X8J5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:glutamate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="475" mass="52651" checksum="9A5D7017FF8281AA" modified="1999-11-01" version="1">MSLHQGPRPSRDSDRDRRRLAVNPFHAAANPLGGMTEAPPAHRLPDSPLPPESAYRLVHDELMLDGNARLNLATFVTTWMEPQAGVLMSECRDKNMIDKDEYPRTAELERRCVAMLADLWHAPDPSTAVGCSTTGSSEACMLAGMALKRRWALRNADRYPAKDVRPNLVMGVNVQVCWDKFCNFWEVEARQVPMEGDRFHLDPQAAAELCDENTIGVVGILGSTFDGSYEPVADLCAALDALQERTGLDVPVHVDGASGAMVAPFLDEDLVWDFRLPRVASINTSGHKYGLVYPGVGWALWRDAEALPEELVFRVNYLGGDMPTFALNFSRPGAQVVAQYYNFLRLGREGYRAVQQSARDIAGSLAERVAALGDFRLLTRGDQLPVFAFTTADDVTAYDVFDVSRRLREGGWLVPAYTFPPHREDLSVLRVVCRNGFSADMADLLLADLERLLPELRRQPGPLTRDKGAATGFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC4</accession>
    <name>Q9XAC4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1932</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36004">
        <property type="entry name" value="T36004"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626197.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028051.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1932"/>
    <dbReference type="GeneID" id="1097366"/>
    <dbReference type="KEGG" id="sco:SCO1932"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1958"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_4_2_11"/>
    <dbReference type="InParanoid" id="Q9XAC4"/>
    <dbReference type="OMA" id="HRHAAHL"/>
    <dbReference type="PhylomeDB" id="Q9XAC4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="183"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="368" mass="38767" checksum="DBF94549F6303FF0" modified="1999-11-01" version="1">MIETPSLVDQYCHGVLRTELGLGTFEAQLARTEGPPAPGTTLFDTQTGFAVRRWCPPLLGLEPHCPPARYLARRRELGVMEADRRLLRGSGITTYLVDAGLPGDLTGPTEMATAADADTREIVRLELLAEQVADTSGTVESFLANLAEAVHGAAVNAVAFTSVAGVRHGLALAPEPPGPGEVRGAAARWLTGREVGGELSDPVLLRHLLWIAVASGLPLQLHAGLGEPGLRIDRTDPVLLTDFVRTTAGLGTDLVLLHGYPYHRHAAHLAGVFPHVYADSGAALVRTGARAATVLAEILELAPFGKILFSSGAQGLPELHVVAARLFREALGRVLGTWVAEGAWSPGDAQRVAAMIASGNAARVYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAG2</accession>
    <name>Q9XAG2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5313</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35616">
        <property type="entry name" value="T35616"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629455.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030168.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5313"/>
    <dbReference type="GeneID" id="1100753"/>
    <dbReference type="KEGG" id="sco:SCO5313"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5399"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037318_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAG2"/>
    <dbReference type="OMA" id="GCLPNAW"/>
    <dbReference type="PhylomeDB" id="Q9XAG2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3152" evidence="3">
        <location>
            <begin position="115"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="31547" checksum="625D9A3093BEDBA2" modified="1999-11-01" version="1">MGRSTARRADRRTGPDGSGHRSRARRRSRRGPARAVLACLALGAVLLTAGAAVAYWRETRPPVTDDQVADVTDALDATTRTPSASPSPSASPSPKASASPSASPSSSPSATTIAIPATGPGTFVTARADGTTVGTGSRVRRYKVLVEKGIDVRPSAAAAEISEVLADRRGWTQDGTNSFRLVSSGSYDFVVKIATPGTVDRICGAAGLLTRGEVNCSVGTDVVVNLKRWVLGSPEFDGPIHEYRALIVNHEVGHRIGHGHETCPGAGRPAPAMMQQIKGLKGCVANAWPYDEKGDYLGGPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAN1</accession>
    <name>Q9XAN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6699</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35017">
        <property type="entry name" value="T35017"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630772.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031115.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6699"/>
    <dbReference type="GeneID" id="1102138"/>
    <dbReference type="KEGG" id="sco:SCO6699"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6806"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_7_0_11"/>
    <dbReference type="InParanoid" id="Q9XAN1"/>
    <dbReference type="OMA" id="YRFDIHL"/>
    <dbReference type="PhylomeDB" id="Q9XAN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03463">
        <property type="entry name" value="3_4-PCD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012786">
        <property type="entry name" value="Protocat_dOase_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02423">
        <property type="entry name" value="protocat_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21566" checksum="3C9B56833FA1A716" modified="1999-11-01" version="1">MTKTDTGSPEQVLPTPSHTVGPFYGYALPFRGGEDIAPAGHPDTVTVHGYVYDGEGNPLPDALLELWGPDPGGAVPTADGSMRRDPASGGFLGRNGVEFTGFGRIQTDANGHWYARTLRPGARGRSAPYVSVCVFARGLLVHLFTRIYLPGDEAVLAADPLLARVPAERRDTLVAGDEGHGTYRFNIRLQGEGETVFLEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAS2</accession>
    <name>Q9XAS2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO4580</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34606">
        <property type="entry name" value="T34606"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628742.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029743.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4580"/>
    <dbReference type="GeneID" id="1100020"/>
    <dbReference type="KEGG" id="sco:SCO4580"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4652"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026207_2_1_11"/>
    <dbReference type="InParanoid" id="Q9XAS2"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="PhylomeDB" id="Q9XAS2"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="15"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="122"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB44513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="418" mass="44872" checksum="AD8069132F9576CD" modified="1999-11-01" version="1">MPPFDVPEGDPFGPHNLPYGVFSIPGSLDRTDRTDRTVGVRLGDHVLDAGAAAHALGSPYAALLAQPTLNPLLAAGRTAWSDVRRALTAWVTVPSHRETLEPFFHPLSSVTLHLPFEVADYVDFYASENHARNVGQIFRPDAADSLTPNWKHLPIGYHGRSGTVVVSGTDVVRPSGQRKAPADAAPVFGPSVRLDIEAEVGFVVGVPSELGSPVALGDFREHVFGLCLLNDWSARDVQAWEYVPLGPFLGKSFTTSVSAWITPLDALEEARVAPPERTHELLPYLDDTDTDQDAPGGYDLRISVAVNGHVVSEPPFSTMYWTAAQQLAHMTVNGASLRTGDLYGSGTVSGPTERERGSLLELTWNGRDPLELPNGKRTFLEDGDVVTLSAWAPGPDGVRVGLGEVTGRVVGRGVEQGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5B6</accession>
    <name>GMHA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gmhA</name>
        <name type="ordered locus">SCO6186</name>
        <name type="ORF">SC2G5.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34840">
        <property type="entry name" value="T34840"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630289.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030722.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9Z5B6"/>
    <dbReference type="SMR" id="Q9Z5B6"/>
    <dbReference type="STRING" id="100226.SCO6186"/>
    <dbReference type="GeneID" id="1101627"/>
    <dbReference type="KEGG" id="sco:SCO6186"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6296"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z5B6"/>
    <dbReference type="OMA" id="DVHICVP"/>
    <dbReference type="PhylomeDB" id="Q9Z5B6"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000136546" description="Phosphoheptose isomerase">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="35"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="231" mass="23699" checksum="0C8464639C52B221" modified="1999-05-01" version="1">MTVHPPVVGHCDELQVALGAFRASAHVTQRWGDRLAAVLGGGGRLLAAGNGGSAAQAQHLTAELVGRYRDDRPPFSAIALHADTSSTTAIANDYGVDEVFARQVRAHGRKGDVLMLLSTSGASANLLSAADAARAAGVRVWALTGRAPNPLMAGSDESLCVEAPSTATVQEIHLVAVHMICAAFDAALERGEHGARAAGSAASTGRAARRERAASTGRAAGAGRAAQRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBJ5</accession>
    <name>Q9ZBJ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6479</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35966">
        <property type="entry name" value="T35966"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630562.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030952.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6479"/>
    <dbReference type="ESTHER" id="strco-SC9C7.15C">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1101918"/>
    <dbReference type="KEGG" id="sco:SCO6479"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6580"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="InParanoid" id="Q9ZBJ5"/>
    <dbReference type="OMA" id="YWPYLAE"/>
    <dbReference type="PhylomeDB" id="Q9ZBJ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177077" evidence="2">
        <location>
            <begin position="27"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="91"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="529" mass="56401" checksum="6B99A076C593C10F" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBN9</accession>
    <name>Q9ZBN9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35477">
        <property type="entry name" value="T35477"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630274.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030706.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6170"/>
    <dbReference type="GeneID" id="1101611"/>
    <dbReference type="KEGG" id="sco:SCO6170"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6279"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBN9"/>
    <dbReference type="OMA" id="MVEINFD"/>
    <dbReference type="PhylomeDB" id="Q9ZBN9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="296" mass="31522" checksum="7866367451BBE946" modified="1999-05-01" version="1">MDFLRPASWEEALAAKAEHPTAVPIAGGTDVMVEINFDHRRPEYLMDLGRIGDLTEWEVGETSVRLGASVPYTRIMEDLGTELPGLALASHTVASPQIRNRGGVGGNLGTASPAGDAHPALLAAGAEVEAESVRGTRRIPIDAFYTGVKRNALEPDELIRAVHVAKADGPQQFSKVGTRNAMVIAVCAFGLALHPATRTVRTGIGSAAPTPIRATAAEEFLNAALDEGGFWENGKIVTPSAVKRFADLCAAACNPIDDVRGTADYRRHAVGVMARRTLTWTWESYRGARRTTEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O50532</accession>
    <name>O50532_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5858</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35894">
        <property type="entry name" value="T35894"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629981.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030502.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5858"/>
    <dbReference type="GeneID" id="1101300"/>
    <dbReference type="KEGG" id="sco:SCO5858"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5957"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033532_0_1_11"/>
    <dbReference type="InParanoid" id="O50532"/>
    <dbReference type="OMA" id="WFPEAGP"/>
    <dbReference type="PhylomeDB" id="O50532"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="188"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA15815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="393" mass="41113" checksum="880B301145BB5FA6" modified="1998-06-01" version="1">MPLSMMGIGVVTMISQLTGRYGLAGALSATIALAAAVAGPQVSRLVDRYGQRRVLRPATLVSLTAAAVLLPAAHYGWPDWVLFAACVGIGCVPSLGAMVRARWAALYRGTPQLHTAYSFESVVDEVCFIFGPIISIGLSTAWFPEAGPLLAACFLATGVFWLTSQRATEPEPHPREHKGGGTALRSRGLQVLVGTFAATGTIFGAIDVVTVAFAEEQGHKAAASLVLALYAAGSCTAAMIFGLLRFAGPPERRWLLGVCAMAVSMIPLLLVGNLPFLAAALFVAGLSIAPTMITTMSLIEEHVPRTQLTEGMTWVSTGLAVGVALGSSAGGWVIDASGARAGYGVPAVAGAVAVAVGFLGYRRLKRPEPRRGGTVEQHTHGERQDERPERHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-04-07" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O54146</accession>
    <name>O54146_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5883</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34909">
        <property type="entry name" value="T34909"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630004.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030512.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5883"/>
    <dbReference type="GeneID" id="1101325"/>
    <dbReference type="KEGG" id="sco:SCO5883"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5982"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080732_0_0_11"/>
    <dbReference type="InParanoid" id="O54146"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="63"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA16174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="261" mass="28351" checksum="37C8E0F580532708" modified="1998-06-01" version="1">MREAVSLTDQVVLDASRPLWITHLRPDPRRLTLAVVSIARLRERGPHGLAALRARYLTAAETEQAATLRAPRRRLEWLAGRLALKHAVSAHGRRHWGLAREPRTVEVRAVSGGLQGGRPVVDAPVEVGLTHSGDFAVAVCGPHAVGVDLEHDRPMPPTLARLLDEECDPRAPSADARRLAAMPATLRWTCKEAVLKYYGFGLRIDAGEVALTGWLPDGRFTWRPGGGLLRHAPVAETRRPAGWAGVVAGHHLALVERPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O54188</accession>
    <name>O54188_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5959</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35724">
        <property type="entry name" value="T35724"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630076.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030565.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5959"/>
    <dbReference type="GeneID" id="1101401"/>
    <dbReference type="KEGG" id="sco:SCO5959"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6056"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_5_2_11"/>
    <dbReference type="InParanoid" id="O54188"/>
    <dbReference type="OMA" id="IAMMMYR"/>
    <dbReference type="PhylomeDB" id="O54188"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="25810" checksum="BC78F2AE5689B04C" modified="1998-06-01" version="1">MLPIDAAAHGSRWRRRHPVDKAVLGLGLTVLAISLPPWPGAALVLVAALTVLLGPAGVPGRRLWRAYRVPLGFCVTGALPLLVQVGGPDGFLTAADGGAVRAGGLLLRTSAASLGVLLFAFTTPMSDLLPRLVRAGVPAPVVDVALVTYRMSFLLLDSVRRIRQAQAARLGHTTRAAAWRSLGGLGATAFVRAFDRAARLQSGLAGRGYDGTLRVLVPEARVSVPFTAASVALLAALAALTLVLEGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O69835</accession>
    <name>O69835_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6047</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA18981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34685">
        <property type="entry name" value="T34685"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630157.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030617.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6047"/>
    <dbReference type="GeneID" id="1101488"/>
    <dbReference type="KEGG" id="sco:SCO6047"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6148"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="O69835"/>
    <dbReference type="OMA" id="AEQVYIE"/>
    <dbReference type="PhylomeDB" id="O69835"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="284" mass="30082" checksum="BFBDC99EC634EA94" modified="1998-08-01" version="1">MRRELRLDGVGRRYGLRGPWVLRGVELGVPPGALVRVEGANGTGKSTLLRLLAGIDAPTEGRVTGRPRTAYVPERFPPALPFTAAQYLTHLGTVHGLSRRAAARAAGHWLERLGAAGYADTRLSRLSKGSSQKVAVAQALLAEPELLVLDEAWTGLDADARGELERAVAERTAVGGAVVFVDHDPRRLAGVPDAVYAVRDGSLHRRTGPAPVSAGPRVVVRVQGPAGAVLPADVHRTAASAEETGPGSHTLTVPASHSDVLLRTLLTARPPWHVVSVHAPEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O69877</accession>
    <name>O69877_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5589</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34774">
        <property type="entry name" value="T34774"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5589"/>
    <dbReference type="GeneID" id="1101030"/>
    <dbReference type="KEGG" id="sco:SCO5589"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5680"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983231_0_0_11"/>
    <dbReference type="OMA" id="WGPPERC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="31178" checksum="9C40EB2BF6D0858F" modified="1998-08-01" version="1">MTPTLVRQHSSHAQATPHVDPRARARDWSEIQERMLVPLYEAVYERLDVGGDTRMLGLNCGSGLALLMAASRGAAVTGVDSRSPELLDLARRRLLSGTSGDPGADSTVSTRTRGDAPRIVQGTPGDAADPTAPAFTLVTAFEPGGCRAGDSETLGDLLARATPLAARGAAVVLAGWGPPERCATTSVLRVAAKLTDPTHGTGGWRPALRDDLEEVAQRAGLRPDGSGRVACPFGYADTGSAVRGLLSTGMFDAAVAATDRDQVDKELTEALHPYQRPDGTVWMPNVFRYLIARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O86653</accession>
    <name>O86653_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ATP/GTP binding protein (Putative membrane protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5734</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T10929">
        <property type="entry name" value="T10929"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629860.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030426.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5734"/>
    <dbReference type="GeneID" id="1101173"/>
    <dbReference type="KEGG" id="sco:SCO5734"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5822"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003134_1_0_11"/>
    <dbReference type="InParanoid" id="O86653"/>
    <dbReference type="OMA" id="WEWMKWL"/>
    <dbReference type="PhylomeDB" id="O86653"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="451"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="814"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="474"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="833"/>
            <end position="840"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA20269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1321" mass="143530" checksum="65C36645E4E7C6ED" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O86691</accession>
    <name>O86691_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO6645</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35054">
        <property type="entry name" value="T35054"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630721.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031071.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6645"/>
    <dbReference type="GeneID" id="1102084"/>
    <dbReference type="KEGG" id="sco:SCO6645"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6750"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031271_1_0_11"/>
    <dbReference type="InParanoid" id="O86691"/>
    <dbReference type="OMA" id="LPALGWY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="380"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA20556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="601" mass="61217" checksum="78601FC5AB2DCB9C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O86796</accession>
    <name>O86796_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4755</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35584">
        <property type="entry name" value="T35584"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628913.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4755"/>
    <dbReference type="GeneID" id="1100196"/>
    <dbReference type="KEGG" id="sco:SCO4755"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4827"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_0_0_11"/>
    <dbReference type="InParanoid" id="O86796"/>
    <dbReference type="OMA" id="TGVRMDH"/>
    <dbReference type="PhylomeDB" id="O86796"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="123"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="360" mass="36884" checksum="D4AA3065D6A5D1AF" modified="1998-11-01" version="1">MGTRTGRDGQGGGGRMAARGGQDGRGGRRKALKAAGVALVGSLLLGAGAAGWAYWHLNGNIRSVDINGALGDDRPARPATVPSASPSASPVPTGALNILVLGSDSRTGEQNQELGGGDSGGARSDTAMVVHLDAGRTAATVVSIPRDTLVERPSCPLPSGGTTRAASGAMFNTAYELGGPVCAVKTVESLTGVRMDHYVEVDFSGFADLVDALGGVTVTTDVDIDDDKSHLHLDAGTHHLDGTEALGLARTRYGLAGGSDLARIELQHKLVKALLQQVSATDLLTDPAKLYQVADALTGSLTTDTGLDSLGELTNLGRSLGDLAADDVRTLTMPVLPAPSDPNRVVADQPDAAELWESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O88068</accession>
    <name>O88068_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1611</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36846">
        <property type="entry name" value="T36846"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625887.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977216.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1611"/>
    <dbReference type="GeneID" id="1097042"/>
    <dbReference type="KEGG" id="sco:SCO1611"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1623"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="O88068"/>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="PhylomeDB" id="O88068"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="27348" checksum="B6A29754AE97026A" modified="1998-11-01" version="1">MSEDIVCRRLVGRTAVVTGAGSGIGLAATRRLASEGAHVVCGDVDETRGRAAAEETGGIFVQADVTDPEQVEALFAAAYDTYGSVDVAFNNAGISPPDDDSILETGLEAWQRVQEVNLTSVYLCCKAAIPYMRRQGRGSIINTASFVARMGAATSQISYTASKGGVLAMSRELGVQFAREGIRVNALCPGPVDTPLLRELFAKDPERAARRLVHIPVGRFAEAEEIAAAVAFLASDDSSFVNATDFLVDGGISGAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O88073</accession>
    <name>O88073_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1616</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36851">
        <property type="entry name" value="T36851"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625892.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977210.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1616"/>
    <dbReference type="GeneID" id="1097047"/>
    <dbReference type="KEGG" id="sco:SCO1616"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1630"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_11"/>
    <dbReference type="InParanoid" id="O88073"/>
    <dbReference type="OMA" id="IEGPCHH"/>
    <dbReference type="PhylomeDB" id="O88073"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="33489" checksum="E864048EDBDC2AE5" modified="1998-11-01" version="1">MGSGAGSSTNGGTGGGTEGGHDTRARQVAGSLAHRVPDLGAMELLLAVARLGSLGGAARELGITQPAASSRIRSMERQLGVALVDRSPRGSRLTDAGALVTDWARRIVEAAEAFDAGAQALRDRRDSRLRVAASMTIAEYLLPGWLVALRAQLPDTAVSLLAGNSAAVAERLLADDADLGFVEGVSVPTGLDSAVIGHDRLIVVTAPGHPWARRRRPLEAAELAATPLILREKGSGTRQVLDAALGGLARPLIELSSTTAVKAAAVGGAGPSVLSELAVGEELTTRRLVSVPVADVVLARDLRAVWPTGHRPTGPARQLLSLTRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>P23155</accession>
    <name>KAS1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative polyketide beta-ketoacyl synthase 1</fullName>
            <ecNumber>2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>WhiE ORF III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5318</name>
        <name type="ORF">SC6G9.15</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Mol. Microbiol." volume="4" first="1679" last="1691">
            <title>Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics.</title>
            <authorList>
                <person name="Davis N.K."/>
                <person name="Chater K.F."/>
                <person name="Bruton C.J."/>
            </authorList>
            <dbReference type="PubMed" id="2077356"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1990.tb00545.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Involved in developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics which is essential for spore color in Streptomyces coelicolor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-"/>
    <dbReference type="EMBL" id="X55942">
        <property type="protein sequence ID" value="CAA39408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S11974">
        <property type="entry name" value="S11974"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629460.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973654.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P23155"/>
    <dbReference type="SMR" id="P23155"/>
    <dbReference type="STRING" id="100226.SCO5318"/>
    <dbReference type="GeneID" id="1100758"/>
    <dbReference type="KEGG" id="sco:SCO5318"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5404"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="InParanoid" id="P23155"/>
    <dbReference type="OMA" id="YRYIKYK"/>
    <dbReference type="PhylomeDB" id="P23155"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000180341" description="Putative polyketide beta-ketoacyl synthase 1">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="423" mass="44815" checksum="195E895027404A43" modified="1991-11-01" version="1">MTRRRVAVTGIGVVAPGGIGTPQFWRLLSEGRTATRRISLFDPSGLRSQIAAECDFEPSDHGLGLATAQRCDRYVQFALVAASEAVRDANLDMNREDPWRAGATLGTAVGGTTRLEHDYVLVSERGSRWDVDDRRSEPHLERAFTPATLSSAVAEEFGVRGPVQTVSTGCTSGLDAVGYAYHAVAEGRVDVCLAGAADSPISPITMACFDAIKATSPNNDDPAHASRPFDADRNGFVMGEGAAVLVLEDLEHARARGADVYCEVSGYATFGNAYHMTGLTKEGLEMARAIDTALDMAELDGSAIDYVNAHGSGTQQNDRHETAAVKRSLGEHAYATPMSSIKSMVGHSLGAIGSIELAACVLAMAHQVVPPTANYTTPDPECDLDYVPREARERTLRHVLSVGSGFGGFQSAVVLSGSEGGLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>P37977</accession>
    <name>Y4036_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO4036</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4036</name>
        <name type="ORF">2SCD60.02c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Mol. Microbiol." volume="17" first="37" last="48">
            <title>A new RNA polymerase sigma factor, sigma F, is required for the late stages of morphological differentiation in Streptomyces spp.</title>
            <authorList>
                <person name="Potuckova L."/>
                <person name="Kelemen G.H."/>
                <person name="Findlay K.C."/>
                <person name="Lonetto M.A."/>
                <person name="Buttner M.J."/>
                <person name="Kormanec J."/>
            </authorList>
            <dbReference type="PubMed" id="7476207"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1995.mmi_17010037.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="L11648">
        <property type="protein sequence ID" value="AAA93051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S69775">
        <property type="entry name" value="S69775"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628218.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974926.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P37977"/>
    <dbReference type="SMR" id="P37977"/>
    <dbReference type="STRING" id="100226.SCO4036"/>
    <dbReference type="GeneID" id="1099472"/>
    <dbReference type="KEGG" id="sco:SCO4036"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4099"/>
    <dbReference type="eggNOG" id="ENOG5033H6W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_8_0_11"/>
    <dbReference type="InParanoid" id="P37977"/>
    <dbReference type="OMA" id="FATWVIA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205349" description="Uncharacterized protein SCO4036">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00835"/>
        </source>
    </evidence>
    <sequence length="97" mass="11121" checksum="0BE63D5661AB3860" modified="1994-10-01" version="1">MIRHLVLFKLNDGVGRDEPRVLAGVEAFRALGGQIEDLRFWECAWNISDRPIAYDFAINSAVDDADALKRYLEHPAHQAGVALWREFATWVIADYEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>P40179</accession>
    <name>Y4760_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO4760</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4760</name>
        <name type="ORF">SC6G4.38</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1994" name="Gene" volume="144" first="97" last="101">
            <title>Characterization of two groEL genes in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Duchene A.M."/>
                <person name="Kieser H.M."/>
                <person name="Hopwood D.A."/>
                <person name="Thompson C.J."/>
                <person name="Mazodier P."/>
            </authorList>
            <dbReference type="PubMed" id="7913076"/>
            <dbReference type="DOI" id="10.1016/0378-1119(94)90210-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-249</scope>
        <source>
            <strain>A3(2) / J1501</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X75206">
        <property type="protein sequence ID" value="CAA53017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35589">
        <property type="entry name" value="T35589"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628918.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029848.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P40179"/>
    <dbReference type="SMR" id="P40179"/>
    <dbReference type="STRING" id="100226.SCO4760"/>
    <dbReference type="GeneID" id="1100201"/>
    <dbReference type="KEGG" id="sco:SCO4760"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4832"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_7_1_11"/>
    <dbReference type="InParanoid" id="P40179"/>
    <dbReference type="OMA" id="GQRAEIC"/>
    <dbReference type="PhylomeDB" id="P40179"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014234" description="Uncharacterized protein SCO4760">
        <location>
            <begin position="44"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="68"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="249" mass="26977" checksum="39F3188D9350A688" modified="2000-05-30" version="2" precursor="true">MRRGRSRPAGAAPAALLLPLLLLLPLTGCDRLAAAPAEHAAAAGDPAQDADRGRRLPPVVDHVRTDDPVVFLTYDDGAERDPAFVGLIRERRLPVTLFLTDTVAGPAYGDLARLRPFGASLQNHTLDHRSLRGLPHAGQRAEICGQQTKLRSRFGVRAHLFRPPHGTYDTTTLRAAADCGITALVLWRATLDADGALTYTRGDHRLHPGDIVAVDPDHPTAANLAARTERLLETIEEQGLRVGNLENYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKI8</accession>
    <name>Q7AKI8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4768</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35597">
        <property type="entry name" value="T35597"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628926.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948568.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKI8"/>
    <dbReference type="STRING" id="100226.SCO4768"/>
    <dbReference type="GeneID" id="1100209"/>
    <dbReference type="GeneID" id="58474832"/>
    <dbReference type="GeneID" id="63982204"/>
    <dbReference type="GeneID" id="67394167"/>
    <dbReference type="KEGG" id="sco:SCO4768"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4840"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q7AKI8"/>
    <dbReference type="OMA" id="FCDALAM"/>
    <dbReference type="PhylomeDB" id="Q7AKI8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="21955" checksum="F3835464B689CC60" modified="2012-05-16" version="1">MTSVLVCDDSPLAREALRRAVATVPGVERVTTAANGEEVLRRWGADRSDLILMDVRMPGLGGVETVRRLLSADPGARIIMLTVAEDLDGVALAVAAGARGYLHKDASRAELRATVTQALADPTWRLAPRRLRSAEMGAAPTLTAREIQVLEGMSHGRSNAEIGRELFLSEDTVKTHARRLFKKLGASDRAHAVALGFRWGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJJ3</accession>
    <name>Q8CJJ3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7628</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAD55532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A58519">
        <property type="entry name" value="A58519"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733740.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031788.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7628"/>
    <dbReference type="GeneID" id="1103066"/>
    <dbReference type="KEGG" id="sco:SCO7628"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7747"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012344_3_1_11"/>
    <dbReference type="InParanoid" id="Q8CJJ3"/>
    <dbReference type="OMA" id="ANLGWSC"/>
    <dbReference type="PhylomeDB" id="Q8CJJ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004307428" description="GSDH domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="51"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="39922" checksum="14A44A19FAF49919" modified="2003-03-01" version="1">MVNTRTRMSAIVATLGLVGSLALATASADESRTSGSAAQIALTEVARAQNPTAGAAGPQDTVWIAERAGTVRVLGDDGLGEPVLDISDETTTDGERGLLGLAFDERFAHLYLSYTDLEGTSTVDEFAVQDGTVREDTRRTVLTQEQPESNHNGGAITFGPDGYLYIALGDGGGGGDPQGNGQKLDTLLGKLLRIDPQGGDPYAIPEDNPFADDPDARGEIWSYGLRNPWRFSFDAGSGDLLIGDVGQSDWEEIDWAPASSPGGENYGWSQMEGTHPFRGGTEPANHVPPIHEYDRTGLGCSVTGGYVYRGEAVPGLAGQYVYSDYCDGTLRSLEIEDGRVTGEHDLGVNGGEVVSFAQDGDGELYVLAIGGTVSRVDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJX2</accession>
    <name>Q8CJX2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CDA peptide synthetase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3232</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAD55498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36180">
        <property type="entry name" value="T36180"/>
    </dbReference>
    <dbReference type="PIR" id="T36250">
        <property type="entry name" value="T36250"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733597.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028844.1">
        <property type="nucleotide sequence ID" value="NZ_CP042324.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3232"/>
    <dbReference type="ESTHER" id="strco-SCE63.01">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="1098666"/>
    <dbReference type="KEGG" id="sco:SCO3232"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3296"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_0_12_11"/>
    <dbReference type="InParanoid" id="Q8CJX2"/>
    <dbReference type="OMA" id="LFDFWSH"/>
    <dbReference type="PhylomeDB" id="Q8CJX2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2037"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2382"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1010"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAD55498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="2417" mass="258498" checksum="F6B227F6C22A5FF9" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK54</accession>
    <name>Q8CK54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative large, multifunctional secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0505</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAD55445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36423">
        <property type="entry name" value="T36423"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733505.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027168.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0505"/>
    <dbReference type="CAZy" id="CBM35">
        <property type="family name" value="Carbohydrate-Binding Module Family 35"/>
    </dbReference>
    <dbReference type="GeneID" id="1095928"/>
    <dbReference type="KEGG" id="sco:SCO0505"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.485"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302417_0_0_11"/>
    <dbReference type="OMA" id="LMPTVDW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176141" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="2">
        <location>
            <begin position="675"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAD55445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108602" checksum="0577A7984EFD9E74" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWD1</accession>
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        <submittedName>
            <fullName evidence="2">Putative glycine-rich protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">SCP2.23c</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <name>SCP2</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAD12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095063"/>
    <dbReference type="KEGG" id="sco:SCP2.23c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8318"/>
    <dbReference type="HOGENOM" id="CLU_388788_0_0_11"/>
    <dbReference type="OMA" id="TWIQESG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="710" mass="70595" checksum="91B0C7AE1CB9A0FB" modified="2002-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWD5</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
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        <name>SCP2</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="1">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095060"/>
    <dbReference type="KEGG" id="sco:SCP2.17c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8312"/>
    <dbReference type="HOGENOM" id="CLU_2541017_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="83" mass="8621" checksum="61B123935E04D354" modified="2002-03-01" version="1">MTGGPLDGRPVRPEDLSHSMLVAVLMANGGSLTIPVSAFEPDSTGGPDGSWHAVVLEPLGDGTVRLSVRPRPAETDEAGVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IW1</accession>
    <name>Q93IW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1309</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625595.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1309"/>
    <dbReference type="GeneID" id="1096732"/>
    <dbReference type="KEGG" id="sco:SCO1309"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1312"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_2_11"/>
    <dbReference type="InParanoid" id="Q93IW1"/>
    <dbReference type="OMA" id="WTSEMAG"/>
    <dbReference type="PhylomeDB" id="Q93IW1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_ARSR_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12481" checksum="E47D386C6E30F859" modified="2001-12-01" version="1">MHLSPADDAHPRTPGEEQFALAAEILALLGDRTRLTLLHALTGGEADVTTLTEACGAARPAVSQHLARLRLAGLVGTRKEGRRVVYSLRDGHLRRLVDEALNVADHRLGDRPLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JC2</accession>
    <name>Q93JC2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phenylacetic acid degradation protein PaaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7474</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631521.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031685.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7474"/>
    <dbReference type="GeneID" id="1102912"/>
    <dbReference type="KEGG" id="sco:SCO7474"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7585"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082133_1_0_11"/>
    <dbReference type="InParanoid" id="Q93JC2"/>
    <dbReference type="OMA" id="FAATSCK"/>
    <dbReference type="PhylomeDB" id="Q93JC2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011883">
        <property type="entry name" value="PA_CoA_Oase4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02159">
        <property type="entry name" value="PA_CoA_Oxy4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="170" mass="18308" checksum="1EFF7924C71B60F9" modified="2001-12-01" version="1">MTRDPALADARRARHVAEQVPDPELPMLTLADLGVLRDVEVDGDGTVVASLTPTYSGCPAMAEMRADVAARLRAAGYPRVEIRTVLDPPWTSDWITESGRGKLAEHGIAPPGAAPRGPVSLVLSPTRPAVPCPRCGSADTEETSRFAATSCKALWRCRACREPFEYVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JI6</accession>
    <name>Q93JI6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1976</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626238.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976843.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1976"/>
    <dbReference type="GeneID" id="1097410"/>
    <dbReference type="KEGG" id="sco:SCO1976"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2002"/>
    <dbReference type="eggNOG" id="COG5500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111152_2_2_11"/>
    <dbReference type="InParanoid" id="Q93JI6"/>
    <dbReference type="OMA" id="STFVMRG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="16173" checksum="E986D80A3F09CA7F" modified="2001-12-01" version="1">MGEGPYFVLTVLGVLGTGVTAGVFCAFSTFVMRGLAALPPAQGVAAMNAINTAAVRPAFMSVFLGTAVLAAVTAVVTLVLWPEDAAVELLLGSGLFLAGSFGVTAAANVPRNAALLRLEPGAAEAAERWPAYVREWTAWNHVRAVASAAAAVAYVLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RY8</accession>
    <name>Q93RY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6003</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972919.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6003"/>
    <dbReference type="GeneID" id="1101445"/>
    <dbReference type="KEGG" id="sco:SCO6003"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6101"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_1_1_11"/>
    <dbReference type="OMA" id="SKGASWW"/>
    <dbReference type="PhylomeDB" id="Q93RY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="286" mass="31920" checksum="A97276149AF128AB" modified="2001-12-01" version="1">MTPLVDPSLNRRKLRLALRKARERAGLSQREAAEQVEWSQSKLIRVETGTVSVSVSDLRALLALYDITEPGTVEELVEAARGSKGASWWSSYHDVVSPQFAQYLGYEGAARAVDTYHPIVIPGHLQTRAYADALLAERGLAEERVRRIVDLRMERQRRMFDGSGRPAATFVLDEAAVRRQVGGRSVFAEQLAQVIAFAGRDEVTVRVLPFDSGAHYSTLGSFVLLRFPDDDDLLYLEHAAGSMTGGEDLELLARYQECFQTLLERALDENASLDLIDRVKQSLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q93S04</accession>
    <name>Q93S04_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6285</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630383.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972640.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6285"/>
    <dbReference type="GeneID" id="1101726"/>
    <dbReference type="KEGG" id="sco:SCO6285"/>
    <dbReference type="HOGENOM" id="CLU_2481869_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="87" mass="9194" checksum="CBE2013C6E5C02F7" modified="2001-12-01" version="1">MANPMSEILSAQSWRITSGSPSAEEVAAVAVVLSAAMAAEAARAAEDERERSGERRRAGARWLPSAARRRAATSWASPASPSWRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACT9</accession>
    <name>Q9ACT9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.214</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639820.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039512.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095292"/>
    <dbReference type="KEGG" id="sco:SCP1.214"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8154"/>
    <dbReference type="HOGENOM" id="CLU_055261_2_2_11"/>
    <dbReference type="InParanoid" id="Q9ACT9"/>
    <dbReference type="OMA" id="RYGPWAT"/>
    <dbReference type="PhylomeDB" id="Q9ACT9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="16018" checksum="23A06A8CF203630A" modified="2001-06-01" version="1">MGRGELTDAAWERIAPLLPGVGGRGRPWRDHRQVINGVLWRLRTGAPWRDLPERFGPWQTVYERFARWETDGTWARLLEEVQVRDDAVGAVEWTVSVDSTVSRAHQHAAGARKKGRRRGTNWKIRHARRLVRRLAAPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACU3</accession>
    <name>Q9ACU3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.210c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639816.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039508.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095288"/>
    <dbReference type="KEGG" id="sco:SCP1.210c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8148"/>
    <dbReference type="HOGENOM" id="CLU_2182394_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="109" mass="10458" checksum="D991FBEF92BAEF72" modified="2001-06-01" version="1">MRGGGPAPRPEVPVTVSPYHPRVVPPSGPDRPTARPAGPAQVCGIVVFPVVGAALCVHGMPVSDVLGLLAGCGVIGAVTTAVAGGGRALLSAVAGAAVRAAAGTEHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACW8</accession>
    <name>Q9ACW8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.183c</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639767.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039482.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095262"/>
    <dbReference type="KEGG" id="sco:SCP1.183c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8128"/>
    <dbReference type="HOGENOM" id="CLU_1184479_0_0_11"/>
    <dbReference type="OMA" id="CYRPVYE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="234" mass="25026" checksum="70ABD9DB8BAD6A48" modified="2001-06-01" version="1">MGRHKQHKPRRSRGENDRPATEWFGTAFHSTAGMQHLDVRRSGNGVLITSSPAEIDGVPASWPLRLRNDVDGGLNEVGAALAAGRGHVFGVTEGPGQRTALAFLPDHPEEGVGTLARVRTSEDPDGDVVFERSAERPMGLWAEAGESLLRIVPLLGPDAPPADELEDCRLCPGCYRPVYESSSSHTLIGAGPLPLMGLCRLCAEGSTLRSLRQANVPIDTRQRTVLETVAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADI1</accession>
    <name>Q9ADI1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6082</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630190.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030640.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6082"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="GeneID" id="1101523"/>
    <dbReference type="KEGG" id="sco:SCO6082"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6184"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_11"/>
    <dbReference type="InParanoid" id="Q9ADI1"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="PhylomeDB" id="Q9ADI1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="154"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="702" mass="79114" checksum="423D1621B888BE0D" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK70</accession>
    <name>Q9AK70_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENDO3c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4047</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628229.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974916.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4047"/>
    <dbReference type="GeneID" id="1099483"/>
    <dbReference type="KEGG" id="sco:SCO4047"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4109"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117222_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AK70"/>
    <dbReference type="OMA" id="HRYPGSM"/>
    <dbReference type="PhylomeDB" id="Q9AK70"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="2">
        <location>
            <begin position="26"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="21388" checksum="5AD6C1F3A5A005C3" modified="2001-06-01" version="1">MDVTLHLAQDPEADELLGRSPLAALVGMLLDQQVPMEWAFKGPSTIARRMGAEDLDAHDIAAYDPESFAALLSDKPAVHRYPGSMAGRVQQLCRYLVETYDGDAEAVWRGVSTGKELLKRLQELPGFGKQKAQIFLALLGKQLGVRPEGWREAAGAYGEADSFRSVADIRGPESLTKVRAHKQEMKAAAKAAKASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK75</accession>
    <name>Q9AK75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4042</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628224.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974920.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4042"/>
    <dbReference type="GeneID" id="1099478"/>
    <dbReference type="KEGG" id="sco:SCO4042"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4105"/>
    <dbReference type="eggNOG" id="ENOG5032WRF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348331_0_0_11"/>
    <dbReference type="OMA" id="NVYNATP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="83"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="20723" checksum="5AF76EC7B781095A" modified="2001-06-01" version="1">MGGQYKITGDKYPRMRPARRRGRFAVVAVACVTVLGVLGWGTLQLIDVFTGGDKASAAGAAGCATTARASASPAAVVLPKPGQVTVNVLNATTRGGLAQKTADELKKRGFRVGDVSNAPKEYDKKVAGTGLLLGPTTSLKTSLTVLGTQLPGAEHRADAARKGAAVDLIIGNGFKGLAKPADADTALAELAAPRSTPAAEKKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWG0</accession>
    <name>Q9EWG0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629111.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974017.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4959"/>
    <dbReference type="GeneID" id="1100400"/>
    <dbReference type="KEGG" id="sco:SCO4959"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5039"/>
    <dbReference type="eggNOG" id="ENOG5030HUE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178592_0_0_11"/>
    <dbReference type="OMA" id="RMLDGPH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="85" mass="9694" checksum="3D9EDCA6D3184080" modified="2001-03-01" version="1">MNRPRREAAARRIMEQSPPRVPADLYAEAVRRGGRMLRRRTAARRLMWLLLGAAAVAFTVWALTVQPWVEPPSETTPPVTGWEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX43</accession>
    <name>Q9EX43_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0995</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC14363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625291.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027504.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9EX43"/>
    <dbReference type="STRING" id="100226.SCO0995"/>
    <dbReference type="DNASU" id="1096418"/>
    <dbReference type="GeneID" id="1096418"/>
    <dbReference type="KEGG" id="sco:SCO0995"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.993"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_0_11"/>
    <dbReference type="InParanoid" id="Q9EX43"/>
    <dbReference type="OMA" id="ACGKGRH"/>
    <dbReference type="PhylomeDB" id="Q9EX43"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="27744" checksum="B3B4D4F4034E3112" modified="2001-03-01" version="1">MARTGGFQDDDFWTEFHDFLFSEQRHAQAEELLDTSPLLSIPAGARVLDLCCGPGVFTVPLARRGYDVTGVDLSPAMLERARKRAADAGAQVTYVQADARAYEPPGAFDVVLNMFTSFGYFENPADNARVLRTMYACLAPGGTLVLDLAGKELLARKVTPPKVVQRGEDLMVQTDTVLDDWARLRSDWVLVRGERVTRATLVWFVYSAVELRRMVEEAGFGQVEIFGGFDGRPYDENAERLVLRAVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2N9</accession>
    <name>Q9F2N9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3111</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627329.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028774.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3111"/>
    <dbReference type="GeneID" id="1098545"/>
    <dbReference type="KEGG" id="sco:SCO3111"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3175"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9F2N9"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="PhylomeDB" id="Q9F2N9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC09552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="262" mass="28264" checksum="981E96CFFC7D313C" modified="2001-03-01" version="1">MTSAVSIPTHGSTGGRTAVAARARQVVKAYGSGETRVVALDHVDVDIARGQFTAIIGPSGSGKSTLMHCLAGLDTVTGGQIYLDETEITGLKDKKLTQLRRDRIGFIFQAFNLLPTLNAIENITLPMDIAGRKYDRAWLDRVVETVGLAGRLKHRPTQLSGGQQQRVAVARALAAQPEIIFGDEPTGNLDSRAGAEVLGFLRRSVTELGQTIVMVTHDPVAASYADRVLYLADGRIVDEMHKPTAEAVLDRMKDFDARGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2X4</accession>
    <name>Q9F2X4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4587</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628749.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029745.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100027"/>
    <dbReference type="KEGG" id="sco:SCO4587"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4659"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_7_1_11"/>
    <dbReference type="InParanoid" id="Q9F2X4"/>
    <dbReference type="OMA" id="SPLYWYS"/>
    <dbReference type="PhylomeDB" id="Q9F2X4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC08288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="200" mass="22335" checksum="50DDC20E37A75FD3" modified="2001-03-01" version="1">MTRRFLFLTGSTRLDGNTELLARRAADQLPADVERRWIDLARHPLPEFEDLRHDSDHTRPTEGNARLLLDATLAATDIVIASPLYWYTLSTPVKRYLDHWSGWLRTPGLDFKATLAGRTLWGVTALAHEEREVADPLIGALNNSAAYMGMRFGGVLLGNGSKPGDVLRDTEALTRAKTFFAREAPFARFPYEQAEAVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F391</accession>
    <name>Q9F391_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7584</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031763.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7584"/>
    <dbReference type="GeneID" id="1103022"/>
    <dbReference type="KEGG" id="sco:SCO7584"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7699"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_43_2_11"/>
    <dbReference type="InParanoid" id="Q9F391"/>
    <dbReference type="OMA" id="QESWTEI"/>
    <dbReference type="PhylomeDB" id="Q9F391"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="20298" checksum="3B768C8C4D575907" modified="2001-03-01" version="1">MARVGLTTEGLIRAGAETADEIGFERTTPTELARRFGVRTASLYSHVKNAHELKTGIALFALAELADLASEAVAGRAGKDALTAFANVYRDYAREHPGRFAATQFPLDAEAAASSAGGRHAQMSRAILRGYRLAEPHQTHAVRLLGSVFSGFVGLEASGGFSHSAPDSQESWTEILDALDVLLRTWPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3J8</accession>
    <name>Q9F3J8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5267</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030139.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5267"/>
    <dbReference type="GeneID" id="1100708"/>
    <dbReference type="KEGG" id="sco:SCO5267"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5351"/>
    <dbReference type="eggNOG" id="ENOG5032Z20">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186972_1_0_11"/>
    <dbReference type="OMA" id="IDRLATW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC05952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="61" mass="7422" checksum="B169C42D13A95DA2" modified="2001-03-01" version="1">MYFTDRGIEELEKRRGEEEITFEWLAEQLRTFVDLNPDFEVPVERLATWLARLDDDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBN1</accession>
    <name>Q9FBN1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5048</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629200.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973929.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5048"/>
    <dbReference type="GeneID" id="1100489"/>
    <dbReference type="KEGG" id="sco:SCO5048"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5128"/>
    <dbReference type="eggNOG" id="ENOG5033C4E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095244_2_0_11"/>
    <dbReference type="OMA" id="RTWTRYT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC05893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="18818" checksum="ABF08D785DD51B02" modified="2001-03-01" version="1">MKGKQKSARDMILSLGVIVLAAGVIWIFIPHDDGEPDVKRVDYRVELLTAQRAASYPVAAPEGLSEDWKPTSVRFRGDDSDAWHLGFRTPDGEYVAVEQSTKKPSTFIHDASQGGQATERTEEIGGRTWTRYTGGRYDALVLDGTGDMKGATTVVAGTGSFEQLGKMAAALKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBV4</accession>
    <name>Q9FBV4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0003</name>
        <name evidence="2" type="ordered locus">SCO7844</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC03662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAD30877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624364.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631872.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026766.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0003"/>
    <dbReference type="GeneID" id="1095446"/>
    <dbReference type="GeneID" id="1103282"/>
    <dbReference type="KEGG" id="sco:SCO0003"/>
    <dbReference type="KEGG" id="sco:SCO7844"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4"/>
    <dbReference type="eggNOG" id="COG1111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357846_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005114">
        <property type="entry name" value="Helicase_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009492">
        <property type="entry name" value="TniQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03457">
        <property type="entry name" value="HA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06527">
        <property type="entry name" value="TniQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HA" evidence="1">
        <location>
            <begin position="365"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="HA" evidence="1">
        <location>
            <begin position="510"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="HA" evidence="1">
        <location>
            <begin position="658"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC03662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD30877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="783" mass="86433" checksum="545B5563958D5EDF" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC90</accession>
    <name>Q9FC90_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1223</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625512.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977608.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1223"/>
    <dbReference type="GeneID" id="1096646"/>
    <dbReference type="KEGG" id="sco:SCO1223"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1222"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_11"/>
    <dbReference type="InParanoid" id="Q9FC90"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="PhylomeDB" id="Q9FC90"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC01505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="42906" checksum="C808C409C73B56DF" modified="2001-03-01" version="1">MTAPVRTARGSEELIRAEEPVLAHNYHPLPVVVARAEGAWVEDVEGRRYLDMLAGYSALNFGHRHPALVEAAHRQLDRLTLTSRAFHNDRLAGFAERLAALTGTDMVLPMNTGAEAVESGIKVARKWAYDVKGVPADRATIVVAADNFHGRTTTIVSFSTDETARSGFGPFTPGFRIVPYNDLAALEAAVDETTAAVLIEPIQGEAGVLIPDDGYLAGVRELTRRKGCLFVADEIQSGLGRTGHTLAVEHESVVPDVVLLGKALGGGIVPVSAVVGRRDVLGVLHPGEHGSTFGGNPLAAAVGTAVVELLETGAFQRRAAELGAVLREGLAALVGRGVVGFRARGLWAGVDVDPALGSGREISERLMREGILVKDTHGSTIRLAPPLTVTAEELTGALGTLEKVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL7</accession>
    <name>Q9FCL7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7797</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631828.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031921.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7797"/>
    <dbReference type="GeneID" id="1103235"/>
    <dbReference type="KEGG" id="sco:SCO7797"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7912"/>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_217300_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="46" mass="4827" checksum="235492A4CE534716" modified="2001-03-01" version="1">MPVIAMAAWRNLAVGALRLSGIKNIAAGLRCNARDARRPLALLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K473</accession>
    <name>Q9K473_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative secreted glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7212</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631268.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031513.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7212"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="CBM6">
        <property type="family name" value="Carbohydrate-Binding Module Family 6"/>
    </dbReference>
    <dbReference type="GeneID" id="1102650"/>
    <dbReference type="KEGG" id="sco:SCO7212"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7310"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002470_0_1_11"/>
    <dbReference type="InParanoid" id="Q9K473"/>
    <dbReference type="OMA" id="FIVGHDS"/>
    <dbReference type="PhylomeDB" id="Q9K473"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176737" evidence="2">
        <location>
            <begin position="39"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="509"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="702"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="4">
        <location>
            <begin position="846"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB94635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="962" mass="99823" checksum="3FF8A5E3685DFEC6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4D1</accession>
    <name>Q9K4D1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5380</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629519.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030214.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5380"/>
    <dbReference type="GeneID" id="1100820"/>
    <dbReference type="KEGG" id="sco:SCO5380"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5460"/>
    <dbReference type="eggNOG" id="ENOG5031SIB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199862_0_0_11"/>
    <dbReference type="OMA" id="WLFTENV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043762">
        <property type="entry name" value="DUF5708"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18969">
        <property type="entry name" value="DUF5708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="62" mass="6538" checksum="83D86ADA36B827BD" modified="2000-10-01" version="1">MTRASKHLLEGAVTLLAGLALWLFTGDVEVPMVTLTKVGVVLMCVGGAQTAWGLYGAARRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4I6</accession>
    <name>Q9K4I6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7239</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631295.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971907.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7239"/>
    <dbReference type="GeneID" id="1102677"/>
    <dbReference type="KEGG" id="sco:SCO7239"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7339"/>
    <dbReference type="eggNOG" id="COG3662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059206_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K4I6"/>
    <dbReference type="OMA" id="PYAHELY"/>
    <dbReference type="PhylomeDB" id="Q9K4I6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB94053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="300" mass="32974" checksum="C179858F60ED8A40" modified="2000-10-01" version="1">MAATRTNGDPGLFGPDSVTWQAHGDPMMWVAGIRALYLQALHPRAVRGVMQNSDFRRDAWGRLMRTAGFVGTTTYGTTEAAERAGARVRKIHSMLGATDPDTGERYGVDEPALLLWVHCAEIGSYLHVLRRSGFPLTDAHADRYLAEHRHSARLVGLDPASVPANRAELAAYFARVRPELAAGADAHEVDDFLLRPPTHPLLVPARGLLWRRVARLAYDSLPPYAHELYGRSAPPPATVTRRLRATGTLLRLVPARLRWQLPPKHILRAMARLGPGVRPAPYKIGRQAAILDRPGEGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4K5</accession>
    <name>Q9K4K5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO7309</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631364.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031580.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7309"/>
    <dbReference type="GeneID" id="1102747"/>
    <dbReference type="KEGG" id="sco:SCO7309"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7411"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_0_11"/>
    <dbReference type="InParanoid" id="Q9K4K5"/>
    <dbReference type="OMA" id="TPDDMRG"/>
    <dbReference type="PhylomeDB" id="Q9K4K5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="256"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB93747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="444" mass="46306" checksum="CF102F04F8E1EFDD" modified="2000-10-01" version="1">MYRACRKRVDTSESSSQSGTGPDAKAAAPDGTRQRGWRRWAMDTRPLRRPAYRRLWSSTVVTAVGSQLTAVAVPKQIYDITGSSAWVGAASLAGLLPLIVFALWGGAVADTVDRRKLLLITNTGIAVTSLLFWIQAVTGMASVAALMLLLALQQAFWGLNAPARNASIARLVPEDELPAANALGSTVMQTGQVVGPLLAGALIPVIGLPELYLIDALALCVTVWAVYKLPALPPLAGTAVRRAGVREVVAGFRYIARHKVLLLSFLADIVAMVFGMPRALFPQLAAETYAPYGEGLALGLLFAAIPIGAVAGGLFSGTFSRARRHGWMVIGAVVVWGAAITGFGLSGSLWLAVAFLVVAGVADMVSMVFRGAILLSAATDEMRGRMQGVFTVVVAGGPRLADVLHGGAGSAAGAREAVAGGGLLVVAVMLALAVAMPALRRYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4K6</accession>
    <name>Q9K4K6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO7308</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB93746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631363.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031579.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7308"/>
    <dbReference type="GeneID" id="1102746"/>
    <dbReference type="KEGG" id="sco:SCO7308"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7410"/>
    <dbReference type="eggNOG" id="COG1279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087840_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4K6"/>
    <dbReference type="OMA" id="FARPRAW"/>
    <dbReference type="PhylomeDB" id="Q9K4K6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB93746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="204" mass="20686" checksum="DD1BD686CCC04DA1" modified="2000-10-01" version="1">MNNALTAAAAGFGTGLSLIVAIGAQNAFVLRQGVRRDAVLAVVGICALSDAVLIALGVGGVGAVVVAWPGALTAVGWIGGAFLLCYGALAARRVFRPSGALRADGAAAGSRRRAVLTCLALTWLNPHVYLDTVFLLGSVAADRGPLRWTFGLGAAAASLVWFAALGFGARYLGRFLSRPVAWRVLDGLVAATMIVLGVSLVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXJ8</accession>
    <name>Q9KXJ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2322</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626569.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028279.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2322"/>
    <dbReference type="GeneID" id="1097756"/>
    <dbReference type="KEGG" id="sco:SCO2322"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2359"/>
    <dbReference type="eggNOG" id="ENOG50332M6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067571_0_0_11"/>
    <dbReference type="OMA" id="YRYWSFW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176741" evidence="2">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB93442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="22892" checksum="36DBD0BB10501D84" modified="2000-10-01" version="1">MTPRRIVPLLLAAFLLIGTAGQAQAAGYRYWSFWDRDGAKWVYATQGPSMAHPSDGDVQGFRFAVSENSGDAAQPRGTADFASICAKTPAEDGTKRVALVLDFGTAPDAPSGETPPAPRTACARVSPDATTADALAAVAGPLRYNTTALLCAIAGYPKSGCGEQVSRTEKKQYSTAAPEAAEDKGDEDGPSIGLYAGIAVVAALAGAATWQARRRRNATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYC7</accession>
    <name>Q9KYC7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6903</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630972.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031288.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6903"/>
    <dbReference type="GeneID" id="1102342"/>
    <dbReference type="KEGG" id="sco:SCO6903"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7013"/>
    <dbReference type="eggNOG" id="ENOG5030HPE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061400_0_0_11"/>
    <dbReference type="OMA" id="LETIWAF"/>
    <dbReference type="PhylomeDB" id="Q9KYC7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="59"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="29341" checksum="3FCD9EC18D1C11C1" modified="2000-10-01" version="1">MLPDPPRDPFNNLDPAQTVRVLPRHLAGPGQADLETIWAFPFDDGWHLHQGLEGMVFAISPCARLWTRFAPKPEERGADTWTIGMDRAPFGPRAWEITFDATTPAELLRDVHTELLDLYLEDRHSEKNHLVEDPTAPHEVYTPLLTHGWSHSVKTDGTQTFLPPEGLGGVRHRYATTGSDGPVWRAWGGYPSAPHWQAQFSAGAPTTLAAAFTASLISTEPLHRAVKQIPFHTRRHLYVAPAAAPQPPSHLPPAPPSAPHPAGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH8</accession>
    <name>Q9KYH8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2694</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626928.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976105.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2694"/>
    <dbReference type="GeneID" id="1098128"/>
    <dbReference type="KEGG" id="sco:SCO2694"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2750"/>
    <dbReference type="HOGENOM" id="CLU_1495351_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="18698" checksum="6546FD3BF71B938D" modified="2000-10-01" version="1">MSPPLITGLHINAVALGDSCRICAIWRVSRPAGPRPACEPVFALLLPRRGTEQDWAAETALRALGEQRLGDGPVCVDLATTVDGIAVDTLRPGLCEPGLLEASRAALGDGHQEWAELARGDPSAFHAAASDGYVLLRHAAVVTECDPAGPGGRVPVVHAREHRVLRAYGAALLAHAGAGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ78</accession>
    <name>HUTI_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazolonepropionase</fullName>
            <ecNumber evidence="1">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutI</name>
        <name type="ordered locus">SCO3070</name>
        <name type="ORF">SCE25.11c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627290.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028748.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KZ78"/>
    <dbReference type="SMR" id="Q9KZ78"/>
    <dbReference type="STRING" id="100226.SCO3070"/>
    <dbReference type="GeneID" id="1098503"/>
    <dbReference type="KEGG" id="sco:SCO3070"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3130"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ78"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="PhylomeDB" id="Q9KZ78"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:histidine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000306530" description="Imidazolonepropionase">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <sequence length="391" mass="41103" checksum="AA711673E043B990" modified="2000-10-01" version="1">MSSSTVITNIAALVTNDPSLGDHSPLGLVRDAAVVVEGDRVVWTGESSKAPATDNRVDADGRAVLPGFVDSHSHLLFAGDRTEEFNARMSGRPYSAGGIRTTVAATRAASDAELEAGLTRYLAEALRQGTTTFETKSGYGLTTADESRALRVAARHTDEVTFLGAHIVAPELADDPAAYVDLVTGEMLDACAPHARWIDVFCEKGAFDGDQARAILTAGKARGLHPRIHANQLSYGPGVRLAVELDAASADHCTHLTDADVDALANSRTVATLLPGAEFSTRAQWPDARRLIDAGATVALSTDCNPGSSFTSSVPFCIALAVRDMGMTPDEAVWSATAGGAAALRREDVGRLVPGAYADLTLLDAPSHVHLAYRPGVPLVAGVWRRGVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZE6</accession>
    <name>Q9KZE6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7007</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
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        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="30059" checksum="B24B8F72B343E2C3" modified="2000-10-01" version="1">MLPLLLVGVVAVRHRSVLADGFGQLATARWPWLLAAAGATCLTWVAAACTRQGAVVERLPARRLLATQFAAGAANHLLPTGLGASAVNLRFMTVCGLPLARSSAALALYLLAESVGRLAVLGALLIAFPGALRLGTLLPEGAVGPLLVVAGAVPVVAAVVLALLPRLRAALLSFLRTALGEARSVHARPARALALWGGALAFPALQASALVLVGRSLGLTLPAGHMAVAYLAATVAVALVPTPGGIGSVEAALVVALVAAGGPAAVATAVVLAFRLLTVWLPLLPGALTLAALVRMRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZL5</accession>
    <name>Q9KZL5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3029</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627251.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028722.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3029"/>
    <dbReference type="GeneID" id="1098462"/>
    <dbReference type="KEGG" id="sco:SCO3029"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3089"/>
    <dbReference type="eggNOG" id="COG1620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021628_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KZL5"/>
    <dbReference type="OMA" id="VIVLWIQ"/>
    <dbReference type="PhylomeDB" id="Q9KZL5"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="538" mass="55665" checksum="CD9FC4E37EC2BCA8" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZP2</accession>
    <name>Q9KZP2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PTS system sugar phosphotransferase component IIA</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">SCO1390</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625673.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977435.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1390"/>
    <dbReference type="GeneID" id="1096816"/>
    <dbReference type="KEGG" id="sco:SCO1390"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1398"/>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012312_5_0_11"/>
    <dbReference type="InParanoid" id="Q9KZP2"/>
    <dbReference type="OMA" id="HTKHAVG"/>
    <dbReference type="PhylomeDB" id="Q9KZP2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031234">
        <property type="term" value="C:extrinsic component of cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="149" mass="15237" checksum="10873D2E87A45871" modified="2000-10-01" version="1">MTTVSSPLAGRAIGLAAVPDPVFSGAMVGPGTAIDPVREPSEAVAPVDGVIVSLHPHAFVVVDESGHGVLTHLGIDTVQLNGEGFELLVNKGDTVVRGQGVVRWDPAAVEAAGKSPICPIVALEATAEALADLREDGDVKAGESLFLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZT1</accession>
    <name>Q9KZT1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2870</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627098.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028636.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2870"/>
    <dbReference type="GeneID" id="1098304"/>
    <dbReference type="KEGG" id="sco:SCO2870"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2930"/>
    <dbReference type="eggNOG" id="ENOG5034684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2439391_0_0_11"/>
    <dbReference type="OMA" id="QAPWAMR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025843">
        <property type="entry name" value="Actino_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026496">
        <property type="entry name" value="GRASP_targ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14408">
        <property type="entry name" value="Actino_peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04186">
        <property type="entry name" value="GRASP_targ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="10381" checksum="0636725DC5F2BB56" modified="2000-10-01" version="1">MESMVKERVFSPAASTQAPWAMRLVTDRLAVSPAPYTSVTLDPATQTARYTDAVGRVVEMGKHGTSRTSGTASVSGGGDGQQPQPQSQDDTTTDYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZU1</accession>
    <name>Q9KZU1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative molybdopterin converting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4161</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628338.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974810.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4161"/>
    <dbReference type="GeneID" id="1099601"/>
    <dbReference type="KEGG" id="sco:SCO4161"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4226"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_2_1_11"/>
    <dbReference type="InParanoid" id="Q9KZU1"/>
    <dbReference type="OMA" id="KVTVRYW"/>
    <dbReference type="PhylomeDB" id="Q9KZU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="84" mass="8760" checksum="F0E748AB6B163553" modified="2000-10-01" version="1">MAKVTVRYWAAAKAAAGVAEEPYDAATLADALGAVRERHPGELTRVLLRCSFLVDGDPVGTRGHETVRLAEGGTVEVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0E9</accession>
    <name>Q9L0E9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4693</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628852.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029819.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4693"/>
    <dbReference type="GeneID" id="1100134"/>
    <dbReference type="KEGG" id="sco:SCO4693"/>
    <dbReference type="HOGENOM" id="CLU_2496469_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB82061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="86" mass="8939" checksum="2F01F11E96558292" modified="2000-10-01" version="1">MVSRPRRRRPAASSTRETIQPPGTGQLVVWMVTVTLLVAVVGSLANSGMALVGLLVLLPAAAAAHARCGRRLWSAPGPLSSAPPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0J6</accession>
    <name>Q9L0J6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4669</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628829.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029802.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4669"/>
    <dbReference type="GeneID" id="1100110"/>
    <dbReference type="KEGG" id="sco:SCO4669"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4741"/>
    <dbReference type="eggNOG" id="ENOG502ZSN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070329_0_0_11"/>
    <dbReference type="OMA" id="ADVTFVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="379" mass="40217" checksum="79CEC17E95677AD9" modified="2000-10-01" version="1">MSSVPPPDRSDGEPAPSISDEQLEAFLREAADGGGGSAPKEPSARARMVARRLREEAEPEPWRAPQGSPRGDGRGRRRLVGAVVGVVVLAALAVVAVRPSLVLDRLPGGDDASATPTLAAESARPTGAPGEAAGAERATREHPFRGSPAERWAEGADAIEVPAAKPLSGMSKDDVAFALRRTKELLVAANLDPAVLRGERPDEALDVLDPKQPELLPKLRRSLSDPDADHDPLRLFTRFDPAETRLAGDVVKVRGRMTLAAGEPGVVKVDADYTFVYPLVRAGDADGPVARTIIRRVLTLTLNDPAKWNVTEGKLLVEKYFSEYGNTDCDVYDGYLHPGFPDDDGPGGARPTGPPTDPYDRSRPLTGSGPGGCGQVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0W2</accession>
    <name>Q9L0W2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3742</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627933.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029202.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3742"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1099178"/>
    <dbReference type="KEGG" id="sco:SCO3742"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3803"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_5_11"/>
    <dbReference type="InParanoid" id="Q9L0W2"/>
    <dbReference type="OMA" id="MGTYNEE"/>
    <dbReference type="PhylomeDB" id="Q9L0W2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="242" mass="25934" checksum="BE06B2FDD28EB41D" modified="2000-10-01" version="1">MNAVTTSPAPDVDVVLPCLNEAGALPWVLARIPAGWRALVVDNGSTDGSADLARSLGATVVTEPRRGFGAACHAGLTAATADVVCFCDCDASLDPGLLTPFVREIRAGTSDLVLGRRRPQARGAWPVHARAGNLALARMLRRRTGLRLHDLGPLRAARRERLLALGLTDRRSGYPLQMVVRAADAGWRIAEHDVPYLPRTGASKVTGTWRGTWHAVRDMRRVLGEPPGRPVPSDAAHEGNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0X9</accession>
    <name>Q9L0X9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3725</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627916.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029191.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3725"/>
    <dbReference type="GeneID" id="1099161"/>
    <dbReference type="KEGG" id="sco:SCO3725"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3785"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636023_0_0_11"/>
    <dbReference type="OMA" id="WVYIELP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045140">
        <property type="term" value="F:inositol phosphoceramide synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045977">
        <property type="entry name" value="DUF5933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19356">
        <property type="entry name" value="DUF5933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5933" evidence="7">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="155"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB76972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="45600" checksum="3805084F8592E9AA" modified="2000-10-01" version="1">MAGAATLAFLVALEIAARRYGLPGPMTNQAKELVFAPASGPLLYAGLALTMVVLTWRQRLVAAAVAVGVDLTVALVRWAADATASGSHSFGNGALWVVLGCGVLALTRRTGPERILLLKGVGLGLLLVAGRKTGDAWLLITSKTRPDVLDPYVATADHALGNPSWLVGRAVEATGAVGEHILDWVYVQLAVAAVVVALYQLRGVAAERRFPRHHLVRTFLLIGLLGPAIYMIFPVVGPVFAYGTGAFGTGGAEWAIADLWPHTLPPVGPPHAFTYDGVTPRNCMPSLHTAWATVIFIHSRKGPRVLRWAGAFWLVATLTATLGFGYHYAIDLIAGVVFAVTVEAGLRSLDRGWDRSGSLLVAHGALVFTAILASTRYLSLEMARNPWVFGPLLLLAMASVIHGYVRTTKSWEPVTAAPPALPEPRLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L144</accession>
    <name>Q9L144_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7415</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031648.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7415"/>
    <dbReference type="DNASU" id="1102853"/>
    <dbReference type="GeneID" id="1102853"/>
    <dbReference type="KEGG" id="sco:SCO7415"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7525"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_3_1_11"/>
    <dbReference type="InParanoid" id="Q9L144"/>
    <dbReference type="OMA" id="CPHYLGA"/>
    <dbReference type="PhylomeDB" id="Q9L144"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="385" mass="41747" checksum="9777B77B4A2EB0B7" modified="2000-10-01" version="1">MTPLTGQDTPALDECVVDAVDVHAFEVPTDGPEGREQDGTLEWDATTLVLVRVHAGGRTGLGYTYGDVSVASFAHSVLGPVVKGRPVSSPPALWELMGARMRNAGRPGVGAMALSAVDVALWDLKARLLGLPLVHLLPAHHDRVPVYGSGGFTNYPLDRLTDQLAGWVRQGIGRVKLKTSRDPEADPRRLTAVRRAVGDGPEVFTDANGALGRKAALYWAHRFHDEWDVRWFEEPVASADLEGLRMLRERGPARLEITAGEYAFTAQDFANLTEGPAVDCLQADVTRCGGVTGVLEVAGLSAARHLDLSAHCAPAVSAHAFCAVRRLRHLEYFHDHVRVERLLFDGVPSPEGGALRPDTSRPGLGLEVRWADAEPYRVRGVRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1E1</accession>
    <name>Q9L1E1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SCO5464 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5464</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629601.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973534.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9L1E1"/>
    <dbReference type="STRING" id="100226.SCO5464"/>
    <dbReference type="GeneID" id="1100904"/>
    <dbReference type="KEGG" id="sco:SCO5464"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5548"/>
    <dbReference type="eggNOG" id="COG5126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_22_7_11"/>
    <dbReference type="InParanoid" id="Q9L1E1"/>
    <dbReference type="OMA" id="FDEFWAH"/>
    <dbReference type="PhylomeDB" id="Q9L1E1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="70" mass="7742" checksum="82A55B9FF1166480" modified="2000-10-01" version="1">MADIEEARKQFERIDTDGDGLITAAEFKTALAQGGDWNVTESVAEAIIAGRDLDGDKQLSFDEFWAHLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1J2</accession>
    <name>Q9L1J2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2724</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB75313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626957.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028542.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2724"/>
    <dbReference type="TCDB" id="2.A.3.8.26">
        <property type="family name" value="the amino acid-polyamine-organocation (apc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1098158"/>
    <dbReference type="KEGG" id="sco:SCO2724"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2780"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045974_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1J2"/>
    <dbReference type="OMA" id="AFCYSEL"/>
    <dbReference type="PhylomeDB" id="Q9L1J2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB75313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="476" mass="49189" checksum="B3D85592BC3FC0C3" modified="2000-10-01" version="1">MTDTLRPAETAAVPPDTPAPQAPSESRTLKRSIGVVGGTLLTLSCVTPASTLFVVVPDLFGSLGTATALTIAVGSLLCVAVAFCYSELGTLVPSAGGEYAMVSTMAGRLAGWLVFVLSLLVVMIVPPVIAMGTADYLEPVLHLDPSLAGAGVMLLATLAGLLDLRANAWITGVFLVLEVIAAAVVAVLGFAHAERGPGSLVSMEVGGTGGGADPVTAMLVVSGLAIALFITQGFSTAVYLSEELENPRRNVARTVLATLAISTVIILVPVVAITFGASDLAELTGGDISAMVTAWSNSAVGTFVSLCVALAIVNAGIVMVIQNSRVLFASARDKAWPAPVNGLLGRLGRFGSPWVATLAVGVPGAALCYVDLDTLYGVTGVSVTAMYLLVAVAALLSRRGAHRHAHAWRMPLWPVVPVLLIAVLAYVLTQQEASHLLLTGSIAAVATLYWALYLRPRLDTRWLVTVPQDVREPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1M6</accession>
    <name>Q9L1M6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6889</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630959.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031274.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6889"/>
    <dbReference type="GeneID" id="1102328"/>
    <dbReference type="KEGG" id="sco:SCO6889"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7000"/>
    <dbReference type="eggNOG" id="ENOG5030RJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094228_1_0_11"/>
    <dbReference type="OMA" id="QWCDDRL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="27049" checksum="0FC5D70C284473C8" modified="2000-10-01" version="1">MLSPTEPAPTPKAIPHVDFELDDLDADEERYLDFYRKVAVHEDMLVPLAAHHDGPNSYYVLFDRAATWGPGMPQVLAVHLQRDYEKRTFSFEQAPLPLPAMAQSWLVHRGCPHDAISLGPELGPPPADEATRALERRLVGDGDRYAMGYSYTSDDPDDMVIVVVLRALDEQALSPFRVVVEEVDTETWTHTLREGGFDTAGEALQWCDDRLTGEAGPLPPVRPAATAGHPAGVAKAPAPRPPGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Q1</accession>
    <name>Q9L1Q1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6864</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630934.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031249.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6864"/>
    <dbReference type="GeneID" id="1102303"/>
    <dbReference type="KEGG" id="sco:SCO6864"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6974"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465925_0_0_11"/>
    <dbReference type="OMA" id="HAAHSVW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB72369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="596" mass="63100" checksum="42CAFB32E64EA662" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1Z5</accession>
    <name>Q9L1Z5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ordered locus">SCO2640</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB71815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626876.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028472.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2640"/>
    <dbReference type="GeneID" id="1098074"/>
    <dbReference type="KEGG" id="sco:SCO2640"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2686"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L1Z5"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="PhylomeDB" id="Q9L1Z5"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAB71815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="35796" checksum="CE9CCF26C59EA09B" modified="2000-10-01" version="1">MRVGIVGATGQVGTVMRRILTERDFPVTELRLFASARSAGKELDGVTVEDAATADYSGLDIVLFSAGGATSKALAEKVASQGPVVIDNSSAWRRDPEVPLVVSEVNPHAITDRPKGIIANPNCTTMAAMPVLRPLHAEAGLEAVVVATYQAVSGSGLAGVDELFEQVQKVGADAPKLTHDGSAVEFPKPDKYVAPIAYNVLPLAGSIVDDGLHETDEEQKLRNESRKILEIPELKVSGTCVRVPVFSGHSLQINARFARPISVERAKELLAGAPGVALTEVPTPLEAAGQDPSYVGRIRQDETVDNGLALFVSNDNLRKGAALNAVQIAELVAAELSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L283</accession>
    <name>Q9L283_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1526</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027829.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1526"/>
    <dbReference type="GeneID" id="1096952"/>
    <dbReference type="KEGG" id="sco:SCO1526"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1535"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_3_0_11"/>
    <dbReference type="InParanoid" id="Q9L283"/>
    <dbReference type="OMA" id="GMRSYMR"/>
    <dbReference type="PhylomeDB" id="Q9L283"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="311" mass="33636" checksum="1520AB3BD83762BF" modified="2000-10-01" version="1">MSARDRLTDGLYGAGWGTVKKLPEPAAVRLGRTIADVAWKRRGAGVRRLESNYARVVPGASPERLAALSRAGMRSYLRYWMESFRLPAWSTERIKSGFAPKDLHHLTDGMDAGKGVILALPHLANWDLAGAWVTTKLGIPFTTVAERLKPETLYDRFVAYREGLGMEVLPHSGGTAFGTLARRLRDGGLVCLVADRDLSASGVEVGFFGETARMPAGPALLAQQTGALLLPVTLWYDDSPVMRGRVHPPVEVPESGTRADKTSVMTQALADAFATGIADHPEDWHMLQRLWLKDLDPAKAPGAADGRGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2A5</accession>
    <name>Q9L2A5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5417</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629556.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030232.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5417"/>
    <dbReference type="GeneID" id="1100857"/>
    <dbReference type="KEGG" id="sco:SCO5417"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5498"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="InParanoid" id="Q9L2A5"/>
    <dbReference type="OMA" id="PCGATTS"/>
    <dbReference type="PhylomeDB" id="Q9L2A5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="40"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="34914" checksum="A8A43FB244A5C7C8" modified="2000-10-01" version="1">MVRARADGQHGGMTSTDTPANGASPHGAPTMLALHQTALGGPEVLRPTELPRPAPGPGEILVAVHAAGLNPTDFKHRALKIFLPPPPLTLGWDVSGTVVETGFGVTLFRPGDEVFGMLPYPHGHGSHAEYVTGPARAFAAKPAGTDHVQAAALPLAALTAWQALVDTAGLRAGQRVLIHAAAGGVGHLAVQIAKERGAHVTGTASAPKHAFLRELGADACVDYRSADFTDTEERYDVVLDTLGGETATRSVGVLRPGGIVVSLLPGDAHTGAAAERAGVRAVVLLVEHDHAGMRAIADLVERGSLRAHVSGTFPLAEGARAHAEGETGRTTGKLVLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2B4</accession>
    <name>Q9L2B4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629545.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973591.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5406"/>
    <dbReference type="GeneID" id="1100846"/>
    <dbReference type="KEGG" id="sco:SCO5406"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5488"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070544_0_0_11"/>
    <dbReference type="OMA" id="VGWADCP"/>
    <dbReference type="PhylomeDB" id="Q9L2B4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB70636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27101" checksum="896A77EC95DA1938" modified="2000-10-01" version="1">MSTVHHDPATLPADDNVNAYTFCVELKGSQWFLQKGKMIAYYGTIDFNGIGHGRLDRLVRTSFHSPLHASDWVVAEGSGKMLLADRAFDVNSYDLEDGNLTIRSGNLLAFQPSLALKQSIVPGFLTLIGTGKFVAASNGPVVFMEPPIRVDPQALVGWADCPSPCHHYDHGYMTGLLGGLRAMTGLGGASGEEHQFEFVGAGTVLLQSSEALMAEQAVGAPPQQAGVPGAGAPGASGGRSGVPGLPGQLGDLQRRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2B6</accession>
    <name>Q9L2B6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO5404</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629543.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973593.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5404"/>
    <dbReference type="GeneID" id="1100844"/>
    <dbReference type="KEGG" id="sco:SCO5404"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5486"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_11"/>
    <dbReference type="InParanoid" id="Q9L2B6"/>
    <dbReference type="OMA" id="LTNMRTE"/>
    <dbReference type="PhylomeDB" id="Q9L2B6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176836" description="Histidine kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="208"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="270"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="478" mass="49935" checksum="1D5B133E46F13DDA" modified="2000-10-01" version="1">MSRLFASVRARATLAATLVVAVALVAAGTAVLLSLRSNLLGEAGTQAERSAREVATELAVGTPYADLSLDVDDRPVQVVDDDGVLVAASEDLERISGTGVDAVKPRPAASPGGEDDDADDDSGESLEPGEIGGRITVSDGSATIDGDTEDYRFAAVPVKTEDRGTLTVYAGAPLSAEHGAVNTALTVMLIGFPLLLAVVAWVTWLVTRRALRPVEGIRREMAAITASEDLARRVPVPGTHDEVARLATTTNETLAALESSVERQRGFVADASHELRSPIASLRTQLEVAAAHPELLDLDGAVADTVRLQRLAADLLLLARLDAGERPADARVDLAALAREAAEGRAGVRVRGDEGVVSAAGSRGQLGRVLANLLDNAERHARSVVEVSVRWDGDTALVAVTDDGEGVPAADRERIFERFVRLDDARSRDDGGAGLGLAIARDVAVRHGGTLTVHDAPAGGALFELRLPGDRAGTARDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="146" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2D2</accession>
    <name>Q9L2D2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="5">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">SCO2487</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="5"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626729.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028382.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2487"/>
    <dbReference type="GeneID" id="1097921"/>
    <dbReference type="KEGG" id="sco:SCO2487"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2529"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L2D2"/>
    <dbReference type="OMA" id="FAQVDPW"/>
    <dbReference type="PhylomeDB" id="Q9L2D2"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017121">
        <property type="entry name" value="Nitrite_Rdtase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037149">
        <property type="entry name" value="NirB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03460"/>
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        <source>
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            <dbReference type="Pfam" id="PF07992"/>
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            <dbReference type="Pfam" id="PF18267"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB69775.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="871" mass="92443" checksum="C06D43C7A035EA41" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2K4</accession>
    <name>Q9L2K4_STRCO</name>
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        <submittedName>
            <fullName evidence="10">Probable ABC transporter protein, ATP-binding component</fullName>
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        <name evidence="10" type="ordered locus">SCO0700</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
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                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
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            <begin position="33"/>
            <end position="58"/>
        </location>
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            <begin position="385"/>
            <end position="392"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="589" mass="63960" checksum="E6214AD72EAA0FF4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-10-16" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD25</accession>
    <name>THIO2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative thioredoxin 2</fullName>
            <shortName>Trx-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trxC</name>
        <name type="ordered locus">SCO0885</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Mol. Microbiol." volume="39" first="1036" last="1047">
            <title>Mutational analysis of RsrA, a zinc-binding anti-sigma factor with a thiol-disulphide redox switch.</title>
            <authorList>
                <person name="Paget M.S."/>
                <person name="Bae J.B."/>
                <person name="Hahn M.Y."/>
                <person name="Li W."/>
                <person name="Kleanthous C."/>
                <person name="Roe J.H."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="11251822"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.2001.02298.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expressed from 2 promoters, 1 of which (trxCp1) is under control of SigR. Dramatically but transiently induced by the thiol-oxidizing agent diamide. In an rsrA mutant expression is constitutive and uninduced by diamide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625184.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027416.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RD25"/>
    <dbReference type="SMR" id="Q9RD25"/>
    <dbReference type="STRING" id="100226.SCO0885"/>
    <dbReference type="GeneID" id="1096308"/>
    <dbReference type="KEGG" id="sco:SCO0885"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.876"/>
    <dbReference type="eggNOG" id="COG0526">
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    <dbReference type="HOGENOM" id="CLU_090389_10_4_11"/>
    <dbReference type="InParanoid" id="Q9RD25"/>
    <dbReference type="OMA" id="QRVDMIN"/>
    <dbReference type="PhylomeDB" id="Q9RD25"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000423655" description="Putative thioredoxin 2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="11251822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="134" mass="14589" checksum="C526A78C04B4E444" modified="2000-05-01" version="1">MTSTVELTKENFDQTVTDNEFVLIDFWAEWCGPCKQFGPVYEKAAEANPDLVFGKVDTEAQPELAQAFGISSIPTLMIVREQVAVFAQPGALPEAALTDVIGQARKLDMDEVRKAVAEQQAQAGQNGQEGQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD31</accession>
    <name>Q9RD31_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0878</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625178.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027411.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0878"/>
    <dbReference type="ESTHER" id="strco-SCM1.11">
        <property type="family name" value="Aclacinomycin-methylesterase_RdmC"/>
    </dbReference>
    <dbReference type="GeneID" id="1096301"/>
    <dbReference type="KEGG" id="sco:SCO0878"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.868"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RD31"/>
    <dbReference type="OMA" id="LNAPCRD"/>
    <dbReference type="PhylomeDB" id="Q9RD31"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="31620" checksum="59F384DCE6618CCC" modified="2000-05-01" version="1">MRNVTIWSEEFGAETDTPILLIMGSMSQGILWPDEFVGRLAAGGRRVIRYDHRDTGRSGTVDFATDPYTWDDIKNDVYRVLAAHGLDSAHLVGHSAGGLLSQLIAVEAPERVRSLTVIASSPLGRGEGQVLLRALTGQPQPKGSLPEPEQEFVEFLRALMAAPPARDRPALIDSMIAEQRVLHGTGLPFDEDAARRLQERVYSRARDLSAASNHRLAAGVSPDFEPVDALHRVKAPTLVIEGSHEPVKPGHGALIAEQIPGARLMTVAGMGHTLPLETHQELADAILTHTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDB4</accession>
    <name>Q9RDB4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2837</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627066.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028609.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RDB4"/>
    <dbReference type="STRING" id="100226.SCO2837"/>
    <dbReference type="GeneID" id="1098271"/>
    <dbReference type="KEGG" id="sco:SCO2837"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2896"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013444_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RDB4"/>
    <dbReference type="OMA" id="WYPTLTT"/>
    <dbReference type="PhylomeDB" id="Q9RDB4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="DUF1929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1929" evidence="3">
        <location>
            <begin position="550"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB65567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="645" mass="70836" checksum="29D5B5969D22F6B6" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDL9</accession>
    <name>Q9RDL9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO2567</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB66245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028431.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.2612"/>
    <dbReference type="eggNOG" id="COG0658">
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RDL9"/>
    <dbReference type="OMA" id="RTDKQGA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ComA-like_MBL"/>
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    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
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    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
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        <location>
            <begin position="608"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAB66245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="855" mass="88522" checksum="F33D833301F1E000" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDN9</accession>
    <name>Q9RDN9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative marR-family transcriptonal regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2398</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="1097832"/>
    <dbReference type="KEGG" id="sco:SCO2398"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="16591" checksum="D093B291960C3959" modified="2000-05-01" version="1">MATPRDTTRRPDALTLEVVELIGEVVARFHADYEEAAAERALTGAQAKLLSLLSLEPLPMRKLAQKLKCEPSNVTGIVDRLEARGLVERRPDPDDRRVKVAAATEEGRRVARGLRESLRFAREPLAGLSEGERVALRDALRLMVGEGSPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIV4</accession>
    <name>Q9RIV4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0952</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625249.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977908.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0952"/>
    <dbReference type="GeneID" id="1096375"/>
    <dbReference type="KEGG" id="sco:SCO0952"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.948"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_2_11"/>
    <dbReference type="InParanoid" id="Q9RIV4"/>
    <dbReference type="OMA" id="AAFQYWV"/>
    <dbReference type="PhylomeDB" id="Q9RIV4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176887" evidence="1">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="430" mass="46312" checksum="151F92EBF5B9C754" modified="2000-05-01" version="1">MPTSRRTFAVAAVAALVLPLSACGSGGDGGSSTDASGKVEGDITFQTWNLRANFKDYFEGLIADFEKKYPDTHVKWVDQPGEGYADKISADAAGGTLPDVVNVSPDLVAPLAKAGLALDLDKAAGQYEKEYLEGAWASHRIPGMDGTYAFPWYLNTGPLFYNKSLFEKAGLDPEQPPRTYDEVFDAALKIADKTDGEVATLANVPTIEDFGRYGVPLMNKEGTAFAFNDAKGVQLLARYKELYDAKALDPQALTATPESSGKKFLTGAVAMNPGSALDLANFKKQAPNLYENIGITDQITSTGHVNMYVMGLMVNAQSQRKPAAVAFAHYVTDAAHQMSFAKQVAIFPSTAGSLDDPYFTKEDGTDETRVRVAAAKSLKTAVNYTPVLFSEQMKTELRNEVAKALQGKQSPKEALDNAVKACDRLLQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ18</accession>
    <name>Q9RJ18_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1850</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976970.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1850"/>
    <dbReference type="GeneID" id="1097284"/>
    <dbReference type="KEGG" id="sco:SCO1850"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1874"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_6_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ18"/>
    <dbReference type="OMA" id="YYHLPKA"/>
    <dbReference type="PhylomeDB" id="Q9RJ18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012804">
        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02442">
        <property type="entry name" value="Cob-chelat-sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="487"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="672" mass="70175" checksum="D19EE363436D6FC9" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ28</accession>
    <name>Q9RJ28_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1840</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626108.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976982.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1840"/>
    <dbReference type="GeneID" id="1097274"/>
    <dbReference type="KEGG" id="sco:SCO1840"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1862"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ28"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="PhylomeDB" id="Q9RJ28"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="531"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="532" mass="57919" checksum="A4554B77A3008979" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ48</accession>
    <name>Q9RJ48_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1820</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626088.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977003.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1820"/>
    <dbReference type="GeneID" id="1097254"/>
    <dbReference type="KEGG" id="sco:SCO1820"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1841"/>
    <dbReference type="eggNOG" id="ENOG5033AAH">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129329_0_0_11"/>
    <dbReference type="OMA" id="LWDVQRW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="16539" checksum="89D783B89705BC24" modified="2000-05-01" version="1">MSGTGVPERSRTRAGRGESDAGGWWKQMRKQSAGGSAEVFRITGARTGLQEDVRGRQRRYIISMSIRTASVILAVCLWNVERHVAIVALVLGAALPYIAVVIANAGRENAPSLPSTFVTAPTPPMIMPPRAGNGAAESVPEGATADPGAGAAGEPHGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ69</accession>
    <name>Q9RJ69_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ordered locus">SCO1632</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625907.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977194.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RJ69"/>
    <dbReference type="STRING" id="100226.SCO1632"/>
    <dbReference type="TCDB" id="2.A.64.2.2">
        <property type="family name" value="the twin arginine targeting (tat) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1097063"/>
    <dbReference type="KEGG" id="sco:SCO1632"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1647"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_6_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ69"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="PhylomeDB" id="Q9RJ69"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009977">
        <property type="term" value="F:proton motive force dependent protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34663" checksum="ED6A6C7662ED5F85" modified="2000-05-01" version="1">MLKPARNKEKDPEGRMPLAEHLRELRNRLAKALLAIVVVTVVAAFFYQWIINALTDPILQSIGCEKSFAELAQSEAGSEPCAQITINGLLGPFTLALKVSLTAGVVLASPVWLYQLWAFVAPGLHRNEKKYAYAFVATGAPLFLAGAYFAYAVLPTSAKVLIEFTPNDVDNLLPLDELLDLVTRMVVVFGLSFELPLLLVMLNFTGVLTGKRMLGWWRAMIMGITLFAAIATPSTDPLTMIMLAGPIWVLYFAAVVVSLLNDRRKARLEALEPDDDEASDLDLTPEDIGEVEPVTTARALPEQATKDRVNGYDDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJY6</accession>
    <name>Q9RJY6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1184</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625474.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027636.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1184"/>
    <dbReference type="GeneID" id="1096607"/>
    <dbReference type="KEGG" id="sco:SCO1184"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1183"/>
    <dbReference type="eggNOG" id="COG3552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272484_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJY6"/>
    <dbReference type="OMA" id="IRDPEWQ"/>
    <dbReference type="PhylomeDB" id="Q9RJY6"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF5682"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05762">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
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        <location>
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            <end position="948"/>
        </location>
    </feature>
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        <location>
            <begin position="982"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1320" mass="135704" checksum="5904AD7F5D1C1E62" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKL2</accession>
    <name>Q9RKL2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4070</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628251.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974902.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4070"/>
    <dbReference type="GeneID" id="1099507"/>
    <dbReference type="KEGG" id="sco:SCO4070"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4129"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030803_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKL2"/>
    <dbReference type="OMA" id="TVSCHHW"/>
    <dbReference type="PhylomeDB" id="Q9RKL2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="505" mass="55876" checksum="F5591D4F2BD8AF99" modified="2000-05-01" version="1">MGSEQIRRWESGALAHAVTDPFGQGPVPWLRGGETYFGDTGQVVAWYADQDRTGTGTDTTTGTRTRIPTGTGTDSGGGPRAADDVRRQIKGFTATGAAAPGEAIDFHVTVDPPQQFSVDVYRIGHYGGDGAAKITTSPRLSGIVQPPPLAADRTVSCHHWWLSWRLQIPTYWNIGAYVAVLTTADGYRSHVPFTVRDDHPADLLLLLPDVTWQAYNLYPEDGRTGASLYHAWDEEGRLLGEADAATTVSFDRPYAGAGLPLHVGHAYDFIRFAERYGYDLAYADARDLHSGRVDPARYRGLVFPGHDEYWSTAMRRTAELARDRGTSLVFLSANTMYWQVELAPSPSGVADRLLTCRKRKGPGRPALWREIDRPEQQLLGIQYAGRVPEPHPMIVRNAGHWLWEATGAHEGDEIEDLVAGEADRYFPRTALPEHDERVLLAHSPYADVDGVRRHQETSLYRAPSGAWVFASGTFAWSPALDRPGHVDPRVQRATANLLDRICKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S247</accession>
    <name>Q9S247_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol dehydrogenase (Zinc-binding)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1705</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36806">
        <property type="entry name" value="T36806"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625979.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027929.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S247"/>
    <dbReference type="STRING" id="100226.SCO1705"/>
    <dbReference type="GeneID" id="1097136"/>
    <dbReference type="KEGG" id="sco:SCO1705"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1723"/>
    <dbReference type="eggNOG" id="COG1062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_11"/>
    <dbReference type="InParanoid" id="Q9S247"/>
    <dbReference type="OMA" id="LNWAPSC"/>
    <dbReference type="PhylomeDB" id="Q9S247"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="16"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB46803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="365" mass="37121" checksum="B1DB5808484C051B" modified="2000-05-01" version="1">MAVRTAVRAAVVPAPGAPLEVTGIELPEPGPGRVRVRLAAAGVCHSDLSLSNGTMRVPLPAVLGHEGAGTVVAVGEGVTHVAPGDEVVLNWAPSCGACHACSLGEVWLCAHALAGAADVHARRADDGTDLHPGLNVAAFAEETVVAASCVLPAPEGIPLTEAALLGCAVLTGYGAVHHSARVREGETVAVFGVGGVGLATLQAARIAGASKIVAVDVSPEKEELARAAGATDYLLASDTTAREIRALTGKQGVDVAVECVGRAVTIRTAWESTRRGGRTTVVGIGGKDQQVTFNALEIFHWGRTLSGCVYGNADPARDLPVLAEHVRAGRLDLGALVTERIALDGIPAAFDNMLAGKGGRALVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2I2</accession>
    <name>Q9S2I2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2021</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35766">
        <property type="entry name" value="T35766"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028101.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2021"/>
    <dbReference type="GeneID" id="1097455"/>
    <dbReference type="KEGG" id="sco:SCO2021"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2051"/>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_4_0_11"/>
    <dbReference type="InParanoid" id="Q9S2I2"/>
    <dbReference type="OMA" id="DVHDKPA"/>
    <dbReference type="PhylomeDB" id="Q9S2I2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071575">
        <property type="term" value="C:integral component of external side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="197" mass="20833" checksum="47555902685020D7" modified="2000-05-01" version="1">MFGSGAVRAEPSLARVRPAVDVLEPSPEQAFQRAGEAVARLREVLRRHGVPDASVSGSRLGLSSEYDGHARGRTLLGYRCQASYAVETGALDDLERLIADVVDAGAHRIDGVEFDVRDRPALLDEARRRAVAAARRKAQVYAEAADARLGPVLHIQDVEAEPVAAFRASAAGGPPGALAPGAVEVSARVVLGFSLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2P9</accession>
    <name>Q9S2P9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2187</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35303">
        <property type="entry name" value="T35303"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626440.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028187.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1097620"/>
    <dbReference type="KEGG" id="sco:SCO2187"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2224"/>
    <dbReference type="eggNOG" id="COG5479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037559_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2P9"/>
    <dbReference type="OMA" id="FNHRTAG"/>
    <dbReference type="PhylomeDB" id="Q9S2P9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="110"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="308" mass="31876" checksum="8B00C1E2D22D4E2F" modified="2000-05-01" version="1">MCGPVKGETPCTGTMVPPGGTAHIADRADPPDSGTMRVFRGPRRARERRAARIPGAVRMPTAARALLGALPGLAAVAALFLCANGVERAADADAEAVPAAATDRYAAPRPDIVPRSVWLGDAARAQPAPRYDDEVVAVFVHHTDTPNGYDCADVPAILRGVYQGQTGARDWDDIGYNFVVDRCGTVYEGRAGGIDRPVTGAHTQGFNHRTTGIAALGTYTAGVPVPDELTDAIAAVAAWKLGETGTDPRAKVALVSSNGLSRYAAGATAMLPAVAGHEDGYQTSCPGAALSARLADIRDTAARLQGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9WX28</accession>
    <name>Q9WX28_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3305</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36253">
        <property type="entry name" value="T36253"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627515.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028897.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1098739"/>
    <dbReference type="KEGG" id="sco:SCO3305"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_0_1_11"/>
    <dbReference type="InParanoid" id="Q9WX28"/>
    <dbReference type="OMA" id="SIGWEVF"/>
    <dbReference type="PhylomeDB" id="Q9WX28"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033692">
        <property type="term" value="P:cellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="32"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB45339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="48648" checksum="C9955AB4BAD4D2F8" modified="1999-11-01" version="1">MRIGKASAGSKPADAPRGSVGQQAPRGRIGILDGLRLCAALMVVLYHYVAFGGGWEGSQAQLFPVLFRPSAYGWLGVELFFMISGFVICMSSWGRSVSHFFTSRVIRLFPAYWLAIAVTTAVVFFMPGGITPLPWRDLLVNLTMLQRPMGVDEVEGVYWTLWAEMRFYLLFALVVWRGVTYRRVVVFCCVWATAAVVAKRGEANPISDLVMAQDCWFFIAGLAFYLMYRFGQNLLLWGMIAFCFAMGNYTAMTTWRATLDNVGDNVPDWGVAVVLTVFFVTMAGVALGWFRRVDWRWLPTAGALTYPLYLLHESIGWEVFHRYQYTVNQWVLVGGTLAGVLVLSYLVHRLVEKPMSKRLKTGLAKAFDQIRAEGATHHERPPTPVGPVRPEPGPPGSGPPGSAPLPQGSGPDLDSPTRTLRLPAAPPPASAAPPRSRPVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X842</accession>
    <name>Q9X842_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6076</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35868">
        <property type="entry name" value="T35868"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630185.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030634.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6076"/>
    <dbReference type="GeneID" id="1101517"/>
    <dbReference type="KEGG" id="sco:SCO6076"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6178"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_11"/>
    <dbReference type="InParanoid" id="Q9X842"/>
    <dbReference type="OMA" id="PGMCFSV"/>
    <dbReference type="PhylomeDB" id="Q9X842"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="158"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB41569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="376" mass="39914" checksum="391A65A5AC7B4692" modified="1999-11-01" version="1">MTGSSPAASFTADDYRARMERAARAAADAGLAGLLVAPGPDLVWLTGYAPTADTERLTLLVLAPDRDPVLVVPTLEAPDAAKAAGAPALTLRDWTDGKDPYAATAALLDGSGRFGISDNAWAMHLLALQRTLPDTSYASLTEALPMLRAVKDAAELELLAAAGAAADAAFEEIRRVRFGGRRESEVAADLADLLRRFGHSQVDFTIVASGPNGANPHHEVGDRVIEDGDMIVLDFGGLKDGYGSDTSRTVHVGAPTDEERRVHDLVREAQEAGFCAVRPGAACQDVDRAARAVIAGAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGVYLPGRFGVRIEDIVTVTEDGGRRLNDTTREMVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8W4</accession>
    <name>Q9X8W4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative delta fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3682</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36617">
        <property type="entry name" value="T36617"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029162.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3682"/>
    <dbReference type="GeneID" id="1099118"/>
    <dbReference type="KEGG" id="sco:SCO3682"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3740"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X8W4"/>
    <dbReference type="OMA" id="QWWKNKH"/>
    <dbReference type="PhylomeDB" id="Q9X8W4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB44385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="345" mass="38022" checksum="1C938614F662DC3A" modified="1999-11-01" version="1">MTMATTATRSDTPGSDFARLSKKVADAGLLGRRPGYYTLRITAVTGLYAAGWAAFVLVGASWWTLAIAAFLAVMYGQVALVAHDMAHRQVFRRRRASELSGRIAGASIGMSYGWWQDKHTRHHANPNTEDLDPDIGPDLLVWSPDQARAATGLPRLLGRWQAFLFFPLLTLEGFNLHVASGRAMANRRLKRRALDGALLLAHCAVYLTALFWVLPPGMAIAFLAVHQCLFGVYLGSAFAPNHKGMPILTADDRPDFLRRQVLTSRNVNGGLFTDLALGGLNHQIEHHLFPSMPSPNLRKARAIVRRYCRDLGVDYAETGLVASYRLALTSLHDAGTPLRRTRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8X5</accession>
    <name>Q9X8X5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3693</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36628">
        <property type="entry name" value="T36628"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627885.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029169.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3693"/>
    <dbReference type="GeneID" id="1099129"/>
    <dbReference type="KEGG" id="sco:SCO3693"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3752"/>
    <dbReference type="eggNOG" id="COG4758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075817_4_0_11"/>
    <dbReference type="InParanoid" id="Q9X8X5"/>
    <dbReference type="OMA" id="TERMDTA"/>
    <dbReference type="PhylomeDB" id="Q9X8X5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB44396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="19585" checksum="C26CF3F34FF347A2" modified="1999-11-01" version="1">MTSLPEESPSLIGEDDREAAVRRLREAYAEGLIAHEVLDGHLHRVLSARTQSELASVVVSLPPEQPGSTATIAAAGGRIKRHGAWRVPRVLKVESAYGRVRLDLSRAVIEHPVVDIELRLGTGGAGITVPRDAVVDVEGLSTGWKDLRYKVPRRSRPGGPTIRISGAMGYGRLKIRHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9V1</accession>
    <accession>Q7AKH3</accession>
    <name>Q9X9V1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ORF8</name>
        <name evidence="3" type="ordered locus">SCO5094</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="4353" last="4364">
            <title>An additional regulatory gene for actinorhodin production in Streptomyces lividans involves a LysR-type transcriptional regulator.</title>
            <authorList>
                <person name="Martinez-Costa O.H."/>
                <person name="Martin-Triana A.J."/>
                <person name="Martinez E."/>
                <person name="Fernandez-Moreno M.A."/>
                <person name="Malpartida F."/>
            </authorList>
            <dbReference type="PubMed" id="10400594"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">J1501</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">A3</strain>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="Y18817">
        <property type="protein sequence ID" value="CAB51133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T45272">
        <property type="entry name" value="T45272"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629244.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030052.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9X9V1"/>
    <dbReference type="STRING" id="100226.SCO5094"/>
    <dbReference type="GeneID" id="1100535"/>
    <dbReference type="KEGG" id="sco:SCO5094"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5174"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_0_0_11"/>
    <dbReference type="OMA" id="ICAHYLH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="208" mass="22299" checksum="22600903962AF651" modified="1999-11-01" version="1">MSTTDAVTFWDGVYAARPAPDAPRPNVRLVETVTGLPPGDALDLGCGSGGDALWLARRGWRVTAVDISGVAAERLAGHARTHGLGDLVDAVRHDLRDSFPEGRFDLVSAHYLHTPFDLDRASVLRGAAHALRPGGRLLVVDHGSTAPWSWDQDPDARHPAPQEVAADLALDPATWRVERAEAPRRTATGPGGRTAEVVDHVLLVRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAM5</accession>
    <name>Q9XAM5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6705</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35023">
        <property type="entry name" value="T35023"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630778.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031120.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102144"/>
    <dbReference type="KEGG" id="sco:SCO6705"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6812"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045984_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAM5"/>
    <dbReference type="OMA" id="PGKTWIN"/>
    <dbReference type="PhylomeDB" id="Q9XAM5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177048" evidence="2">
        <location>
            <begin position="25"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="3">
        <location>
            <begin position="54"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="4">
        <location>
            <begin position="206"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="325" mass="34244" checksum="3462671E026D0278" modified="1999-11-01" version="1">MRRGTRRGRCAALLTAAVAVSLGAAGCTAGPGAQDDGRASTAPVPERSHSAAPASGPVLAVKVDNVRAARPQTGLEDADVVYAEPVEAGLSRLMAIYATELPESVGPVRSARESDLELLGQFDRPVLAFSGAQSKLLPIIDKAPLRAEPASEDSDAYVRAGDRQAPHNLYLRPDELLGKPSGAAALTTGFTYGKAPAGGRAESSHTVRYPSASFAFTWSDSRDRWLVSMDGSPARTADGGRLAPATVVVQHVRVRESDFRDFRGSNSPYVESVGSGEAEVLRDGRVYDATWKRGAAEDGTTYTTGDGKPLNFAEGQVWVVFAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAP7</accession>
    <name>Q9XAP7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4555</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34631">
        <property type="entry name" value="T34631"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628717.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029729.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4555"/>
    <dbReference type="GeneID" id="1099995"/>
    <dbReference type="KEGG" id="sco:SCO4555"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4627"/>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038663_0_0_11"/>
    <dbReference type="OMA" id="PSMGIMF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB44538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="363" mass="40829" checksum="B0514FC0EC102FD3" modified="1999-11-01" version="1">MGAHSRGAVRAVRGEEGAAPVVRDRYFDTLRALALVRVVAYHAFGWPWAGLVLPSMGIMFGLGGTLMARSLRRPAATVFRNRLRRLLPPFWCWGLFVVGAMLARGWMPGWQIVYWVVPLGDPPGSAWGEQAWEILWYLRTYLWFVLLSPLLLRVFRLAPVPVLLLSLAPAVAFQFLWQPPENRFGTGLLDLATYLFCWILGFAHRDGVLGRLKPAAVVVLSLAALACGAWYAFTHRAEYGTYDLDDIPLAQAFWSAGFVTLLMYSKARLGVGLSGLARLRRLDRLVTVFNARAVTVYLWHELALVLAVPLIDRLWDVPAFEAYLPLESQWFLLGVGWVLIAVFVLLFGWVEDVAARKRPRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z557</accession>
    <name>Q9Z557_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35898">
        <property type="entry name" value="T35898"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030660.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6115"/>
    <dbReference type="GeneID" id="1101556"/>
    <dbReference type="KEGG" id="sco:SCO6115"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6218"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_11"/>
    <dbReference type="InParanoid" id="Q9Z557"/>
    <dbReference type="OMA" id="GWNRFPV"/>
    <dbReference type="PhylomeDB" id="Q9Z557"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="42225" checksum="B6194DD7BE7F69DB" modified="1999-05-01" version="1">MNEISTPGRRAAGTSALAARALELIASGRATSRAQLAELLGAAASSVSVAVAQLVEHGLVAEEGTQSSTGGRPRKVLRLGGQDEFAVAADLGGSHARVGVVLPGGELRDVSTVPLVIAEGPQAALSRLAATLEELVEQHGRGRLRGVGLSLPGPVDTATGSVVQPSRMPGWNRFPVESWLRERFAVPAVADNDANCMAVGEHIARKGRHQQVIMVKTGTAIGAAALVDGRLYRGGTGAAGEITHIRIARGDHVPCSCGNTDCLETVASGAALVRVLRDEGVDVTSAEDVVRLATDAHPEANRAVRRAGDYLGQVLAANVNFFNPDAVYLGGILSTVEPFVAAVRSQLYESCHPLVTEHLAIERAVLGRDAGLVGAGLFALQRALGQALRQVGGAQLDPDRFQSPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBF4</accession>
    <name>Q9ZBF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6459</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35946">
        <property type="entry name" value="T35946"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630544.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030937.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6459"/>
    <dbReference type="GeneID" id="1101898"/>
    <dbReference type="KEGG" id="sco:SCO6459"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6559"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_4_11"/>
    <dbReference type="InParanoid" id="Q9ZBF4"/>
    <dbReference type="OMA" id="YHVEHLR"/>
    <dbReference type="PhylomeDB" id="Q9ZBF4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="120" mass="12840" checksum="C345598BB098D423" modified="1999-05-01" version="1">MGHGAATTAQDAAARVRLDADNVTKVATTLQALSTPSRLLILARLREGPLPATELAAEVGMEQSACSHQLRLLRNLGLVVGERRGRSVVYALHDDHVAGLLDQAVYHVEHLRLGISDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBF6</accession>
    <name>Q9ZBF6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO6457</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35944">
        <property type="entry name" value="T35944"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630542.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030935.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6457"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1101896"/>
    <dbReference type="KEGG" id="sco:SCO6457"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6557"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002346_2_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBF6"/>
    <dbReference type="OMA" id="WCDHGIL"/>
    <dbReference type="PhylomeDB" id="Q9ZBF6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177075" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="11">
        <location>
            <begin position="676"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Bgal_small_N" evidence="12">
        <location>
            <begin position="1015"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAA22766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1307" mass="145522" checksum="86DF428BD21AFD87" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBG4</accession>
    <name>Q9ZBG4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35936">
        <property type="entry name" value="T35936"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630534.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030928.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6449"/>
    <dbReference type="GeneID" id="1101888"/>
    <dbReference type="KEGG" id="sco:SCO6449"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6549"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019327_1_1_11"/>
    <dbReference type="InParanoid" id="Q9ZBG4"/>
    <dbReference type="OMA" id="GFRHDPC"/>
    <dbReference type="PhylomeDB" id="Q9ZBG4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="472" mass="50040" checksum="85C875DDAA3BED15" modified="1999-05-01" version="1">MPSMLDAVVVGAGPNGLTAAVELARRGFSVAVFEAQGTVGGGARTEELTLPGFRHDPCSAAHPLGINSPAFRGLPLERYGLEWLHPGLPMAHPFPDGSAAVLSRSVGETAASFGARDAGPYRRLVERFLPRWDTLARDFMSLPLTALPRDPVTLARFGLVGLPPSTWLMRRFRDEKAKTLFAGLVAHVMAPLGGFATGAIGLVFALAAHARGWPVARGGSQSISDALTAYLKDLGGAVHTDYEVKRLDDLPPARAYVFDTSPTALARIAGLGSHYANYRYGPSVFKIDYALDGPVPWTAEEPRSAGTVQIGADSTEIGAALHAASGTDRAPERPFLITVQPSVADPTRAPAGKHVFWAYGHVPNGWNGDLTDAMERQLERFAPGFRDRVLARATAGPAELAARNANYVGGDISSGAVSGLQLLLRPKISLFPYSTPHPAVFICSSATPPGPGVHGMSGHNAAKAVWRRLRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBH4</accession>
    <name>Q9ZBH4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6439</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35926">
        <property type="entry name" value="T35926"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630524.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030920.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9ZBH4"/>
    <dbReference type="STRING" id="100226.SCO6439"/>
    <dbReference type="GeneID" id="1101878"/>
    <dbReference type="KEGG" id="sco:SCO6439"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6539"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874275_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBH4"/>
    <dbReference type="OMA" id="EVRGYGF"/>
    <dbReference type="PhylomeDB" id="Q9ZBH4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="17913" checksum="A6EF7194BE00D845" modified="1999-05-01" version="1">MVPFRGWAPDEGGFQRLGVRMVAGRVVRFDGTRGYGFIAPEDGGEDVFLHVNDLLIPEESVRSGLVVEFEVESGERGLKASGIRLPEGERQPVARRHQEAAPRTAMSDENGHPMCDVLSPEEYRRDVTELLLTASPQLTAEQILTIRGALVKFSEGHGWVED</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBW4</accession>
    <name>Q9ZBW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6554</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34996">
        <property type="entry name" value="T34996"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630635.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031004.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6554"/>
    <dbReference type="GeneID" id="1101993"/>
    <dbReference type="KEGG" id="sco:SCO6554"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6658"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044190_0_0_11"/>
    <dbReference type="OMA" id="RAGRTQW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA22358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="35665" checksum="6A7898F51C7C4A7D" modified="1999-05-01" version="1">MEMESDAFDELDLGLLDALEVNGRASFSRIGAVLGVSDQTVARRYRRLCAEGGLRVVAVRDAERLGQDQWTLRLRCVPDSSAAIADALAKRPDTNWIGVASGGTEVILGTRPRSPGARDDLLLGKLPRTPRVLEIHAHQMLHRFYGGPSGWLRKFGVLSEEQVAALRNEPDPARRGPARIDPEDEPLLAVLERNGRATYPELQRATGRSESAVKRRLAALLASGAVYIDVEYDPDILGYRTDAALWITTSPAALHRVGEALAAHDEIAHVAATAGPSNIIATAVVRSTADLYTYLSGPLGHLEGVQHLEASPLLRRVKRLTYQRPVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-09-26" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZH58</accession>
    <name>CLPP2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 2</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP2</name>
        <name type="ordered locus">SCO2618</name>
        <name type="ORF">SCC80.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1999" name="Mol. Microbiol." volume="32" first="505" last="517">
            <title>Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces.</title>
            <authorList>
                <person name="de Crecy-Lagard V."/>
                <person name="Servant-Moisson P."/>
                <person name="Viala J."/>
                <person name="Grandvalet C."/>
                <person name="Mazodier P."/>
            </authorList>
            <dbReference type="PubMed" id="10320574"/>
            <dbReference type="DOI" id="10.1046/j.1365-2958.1999.01364.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="815" last="825">
            <title>Positive and negative feedback regulatory loops of thiol-oxidative stress response mediated by an unstable isoform of sigmaR in actinomycetes.</title>
            <authorList>
                <person name="Kim M.S."/>
                <person name="Hahn M.Y."/>
                <person name="Cho Y."/>
                <person name="Cho S.N."/>
                <person name="Roe J.H."/>
            </authorList>
            <dbReference type="PubMed" id="19682253"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06824.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Probably partially responsible for degradation of ECF sigma factor SigR prime.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Expressed from 2 promoters, 1 of which (clpP2) is positively regulated by the thio-oxidizing agent diamide, probably via SigR. Probably a clpP1-clpP2 operon.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">A double clpP1-clpP2 deletion increases the stability of ECF sigma factor SigR prime from 10 to 23 minutes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC70948" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAC09994" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AF071885">
        <property type="protein sequence ID" value="AAC70948.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAC09994.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626854.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZH58"/>
    <dbReference type="SMR" id="Q9ZH58"/>
    <dbReference type="STRING" id="100226.SCO2618"/>
    <dbReference type="MEROPS" id="S14.009"/>
    <dbReference type="GeneID" id="1098052"/>
    <dbReference type="KEGG" id="sco:SCO2618"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2664"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_11"/>
    <dbReference type="InParanoid" id="Q9ZH58"/>
    <dbReference type="PhylomeDB" id="Q9ZH58"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179665" description="ATP-dependent Clp protease proteolytic subunit 2">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="19682253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="218" mass="24180" checksum="67082B89EAC49F2E" modified="2001-09-26" version="2">MRAASQGRYTGPQAESRYVIPRFVERTSQGVREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISVYINSPGGSFTALTAIYDTMQYVKPDVQTVCMGQAASAAAVLLAAGTPGKRMALPNARVLIHQPYSETGRGQVSDLEIAANEILRMRSQLEEMLAKHSTTPVEKIREDIERDKILTAEDALSYGLIDQIITTRKMDNSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O50531</accession>
    <name>O50531_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5857</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35893">
        <property type="entry name" value="T35893"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629980.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030501.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5857"/>
    <dbReference type="GeneID" id="1101299"/>
    <dbReference type="KEGG" id="sco:SCO5857"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5956"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_3_11"/>
    <dbReference type="InParanoid" id="O50531"/>
    <dbReference type="OMA" id="YPRFGEF"/>
    <dbReference type="PhylomeDB" id="O50531"/>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080049">
        <property type="term" value="F:L-gulono-1,4-lactone dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="445" mass="49067" checksum="8C0AEFB874E38CF5" modified="1998-06-01" version="1">MSSTRTASGRTSGRNGTWRNWGGNVSARPAREVTPASVDELADAVRRAAEDGQRVKAVGTGHSFTSIAATDGVLIRPQLLTGIRSIDRDAMTVTVEAGTPLKRLNMALAREGLSLTNMGDIMEQTVSGATSTGTHGTGRDSASIAAQIRGLELVTADGSVLTCSADENPEVFAAARIGLGALGVVTAITFAVEPVFLLTAREEPMPFDRVLADFDALWSENEHFEFYWFPHTNSTNTKRNNRSAGPERPVGRFQGWLDDEFLSNGLFQAVNWVGRAAPATIPSIARISSRALSARTYTDTPYKVFTSPRRVRFVEMEYAVPREAVVEVLRELRTMVDRSRLRISFPVEVRTAPADDITLSTASARDSAYIAVHMFRGTPYQAYFTAAERIFTAHEGRPHWGKVHTRDAGYFSRVYPRFGEFTALRDRLDPDRLFQNDYLRRVLGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O54161</accession>
    <name>EABF_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Extracellular exo-alpha-L-arabinofuranosidase</fullName>
            <shortName>ABF</shortName>
            <ecNumber>3.2.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arabinosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Arabinoxylan arabinofuranohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">abfB</name>
        <name type="ordered locus">SCO5932</name>
        <name type="ORF">SC7H1.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydr olase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35697">
        <property type="entry name" value="T35697"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630049.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030541.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="PDB" id="3WMY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=38-475"/>
    </dbReference>
    <dbReference type="PDB" id="3WMZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=38-475"/>
    </dbReference>
    <dbReference type="PDB" id="3WN0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=38-475"/>
    </dbReference>
    <dbReference type="PDB" id="3WN1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=38-475"/>
    </dbReference>
    <dbReference type="PDB" id="3WN2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A=38-475"/>
    </dbReference>
    <dbReference type="PDBsum" id="3WMY"/>
    <dbReference type="PDBsum" id="3WMZ"/>
    <dbReference type="PDBsum" id="3WN0"/>
    <dbReference type="PDBsum" id="3WN1"/>
    <dbReference type="PDBsum" id="3WN2"/>
    <dbReference type="AlphaFoldDB" id="O54161"/>
    <dbReference type="SMR" id="O54161"/>
    <dbReference type="STRING" id="100226.SCO5932"/>
    <dbReference type="CAZy" id="CBM13">
        <property type="family name" value="Carbohydrate-Binding Module Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="GH62">
        <property type="family name" value="Glycoside Hydrolase Family 62"/>
    </dbReference>
    <dbReference type="GeneID" id="1101374"/>
    <dbReference type="KEGG" id="sco:SCO5932"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6029"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041805_2_0_11"/>
    <dbReference type="InParanoid" id="O54161"/>
    <dbReference type="OMA" id="STYRWNS"/>
    <dbReference type="PhylomeDB" id="O54161"/>
    <dbReference type="BRENDA" id="3.2.1.55">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0430">Lectin</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000008036" description="Extracellular exo-alpha-L-arabinofuranosidase">
        <location>
            <begin position="38"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="211"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="224"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="232"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="251"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="307"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="316"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="349"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="356"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="turn" evidence="6">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="414"/>
            <end position="416"/>
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    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="426"/>
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        </location>
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    <feature type="strand" evidence="5">
        <location>
            <begin position="432"/>
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        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
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    <feature type="strand" evidence="5">
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        </location>
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    <feature type="helix" evidence="5">
        <location>
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            <end position="463"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="467"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3WMY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3WN1"/>
        </source>
    </evidence>
    <sequence length="475" mass="50046" checksum="47E707FE543CA60D" modified="1998-06-01" version="1" precursor="true">MHRGSLSRGHTSAVLAAVVAALAALAALLVATTPAQAAGSGALRGAGSNRCLDVLGGSQDDGALLQLYDCWGGTNQQWTSTDTGRLTVYGDKCLDVPGHATAPGTRVQIWSCSGGANQQWRVNSDGTVVGVESGLCLEAAGAGTANGTAVQLWTCNGGGNQKWTGLTGTPPTDGTCALPSTYRWSSTGVLAQPKSGWVALKDFTTVTHNGRHLVYGSTSSGSSYGSMVFSPFTNWSDMASAGQNAMNQAAVAPTLFYFAPKNIWVLAYQWGSWPFIYRTSSDPTDPNGWSAPQPLFTGSISGSDTGPIDQTLIADGQNMYLFFAGDNGKIYRASMPIGNFPGNFGSSYTTIMSDTKANLFEGVQVYKVQGQNQYLMIVEAMGANGRYFRSFTASSLSGSWTPQAASEGNPFAGKANSGATWTNDISHGDLVRDNPDQTMTVDPCNLQFLYQGKSPNAGGDYNSLPWRPGVLTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O69935</accession>
    <name>O69935_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6407</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA19618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34901">
        <property type="entry name" value="T34901"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630494.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030896.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6407"/>
    <dbReference type="MEROPS" id="T03.001"/>
    <dbReference type="GeneID" id="1101846"/>
    <dbReference type="KEGG" id="sco:SCO6407"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6507"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_0_1_11"/>
    <dbReference type="InParanoid" id="O69935"/>
    <dbReference type="OMA" id="KATKNMF"/>
    <dbReference type="PhylomeDB" id="O69935"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174852" description="Glutathione hydrolase proenzyme" evidence="5">
        <location>
            <begin position="25"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA19618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="603" mass="63258" checksum="23C7B8C18A8B51F0" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>O86518</accession>
    <name>O86518_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5536</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29066">
        <property type="entry name" value="T29066"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629670.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030299.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5536"/>
    <dbReference type="GeneID" id="1100976"/>
    <dbReference type="KEGG" id="sco:SCO5536"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5623"/>
    <dbReference type="HOGENOM" id="CLU_175330_3_0_11"/>
    <dbReference type="OMA" id="APHSWQG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="65" mass="7076" checksum="F98B2943DACEEF33" modified="1998-11-01" version="1">MSPADIRVEKGHAEPEEVAAITALLLARAAARPAEIAPTHGGGRARAGWRRLEREPGFRAPHSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O86728</accession>
    <name>O86728_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative secreted cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6546</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35238">
        <property type="entry name" value="T35238"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031000.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6546"/>
    <dbReference type="CAZy" id="CBM2">
        <property type="family name" value="Carbohydrate-Binding Module Family 2"/>
    </dbReference>
    <dbReference type="CAZy" id="GH48">
        <property type="family name" value="Glycoside Hydrolase Family 48"/>
    </dbReference>
    <dbReference type="GeneID" id="1101985"/>
    <dbReference type="KEGG" id="sco:SCO6546"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6651"/>
    <dbReference type="eggNOG" id="COG3188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302839_0_0_11"/>
    <dbReference type="OMA" id="QWFGFQA"/>
    <dbReference type="BRENDA" id="3.2.1.91">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.870.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023309">
        <property type="entry name" value="Endo-1-4-beta-glucanase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027390">
        <property type="entry name" value="Endoglucanase_F_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000556">
        <property type="entry name" value="Glyco_hydro_48F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02011">
        <property type="entry name" value="Glyco_hydro_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00844">
        <property type="entry name" value="GLHYDRLASE48"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174889" evidence="6">
        <location>
            <begin position="40"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA20643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="973" mass="103505" checksum="7CF71C41FBF258BF" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O86761</accession>
    <name>O86761_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5638</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35460">
        <property type="entry name" value="T35460"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629768.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030354.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5638"/>
    <dbReference type="GeneID" id="1101077"/>
    <dbReference type="KEGG" id="sco:SCO5638"/>
    <dbReference type="eggNOG" id="ENOG502ZXJF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080176_0_0_11"/>
    <dbReference type="OMA" id="HTTWRAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041116">
        <property type="entry name" value="SLATT_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18184">
        <property type="entry name" value="SLATT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="32813" checksum="16A05DB79E43F8E1" modified="1998-11-01" version="1">MISLTLQDEDFPELFRVADATSLNGQRLYLLGTRIRLSFAVLAATLAVFSFQVGDKWDVAGLGVALAFLATLLVEIWLLVSRPERDWYDGRAFAESIKTLAWRYSVAATPFPNSEPSSLADQHFAAEIRKLVTEAPSDSIVVVSPVHITNKMSELRRAALEIRREAYLKGRIENQLKWYSDKSRFNVRMARRWRVALIAIEGLGIILAILKAGQTISIDAPGIAAAVLGAGSAWFAVRQYESLGRAYAFAANDLSTVYARLQHIIDENIWAQEVADAEEAISREHTMWRASRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O86809</accession>
    <name>O86809_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5749</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35682">
        <property type="entry name" value="T35682"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030434.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5749"/>
    <dbReference type="GeneID" id="1101191"/>
    <dbReference type="KEGG" id="sco:SCO5749"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5838"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_1_11"/>
    <dbReference type="InParanoid" id="O86809"/>
    <dbReference type="OMA" id="FVELYMK"/>
    <dbReference type="PhylomeDB" id="O86809"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA19850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="24102" checksum="2CD9EF5DC4A39B2B" modified="1998-11-01" version="1">MVQKAKILLVDDRPENLLALEAILSALDQTLVRASSGEEALKALLTDDFAVILLDVQMPGMDGFETAAHIKRRERTRDIPIIFLTAINHGPHHTFRGYAAGAVDYISKPFDPWVLRAKVSVFVELYMKNCQLREQAALLRLQLEGNGKAAVGEAKEPAGLLAELSARLAAVEEQAEALSKQLGDESTDAAAVATAAHLERKLTGLRRALDALEPGSSGGQAAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O86829</accession>
    <name>O86829_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polyamine ABC-transporter integral memb rane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5670</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35800">
        <property type="entry name" value="T35800"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629799.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973355.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5670"/>
    <dbReference type="GeneID" id="1101109"/>
    <dbReference type="KEGG" id="sco:SCO5670"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5756"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_11"/>
    <dbReference type="InParanoid" id="O86829"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="PhylomeDB" id="O86829"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA20219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="29012" checksum="E050A433229A7DC6" modified="1998-11-01" version="1">MAFVNWFKRHVVVIAGLLTLAYLLLPNVVVTVFSFNKPNGRFNYEWQQFSTDAWKDPCGVAGLCGSLSLSLQIALWATLGATALGTAIAFALVRYRFRARGAINSLIFLPMAMPEVVMAASLLTLFLNMGAQLGFWTILIAHIMFCLSFVVTAVKARVMSMDPRLEQAAQDLYAGPFQTFVRVTLPIAAPGIAAGALLAFALSFDDFIITNFNAGSTVTFPMFVWGSAQRGTPVQINVVGTAMFVIAVLFVLVSMVLGNRRNRRKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-11-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>P23159</accession>
    <name>YHB2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein SCO5314</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>WhiE ORF VII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5314</name>
        <name type="ORF">SC6G9.19</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Mol. Microbiol." volume="4" first="1679" last="1691">
            <title>Spore colour in Streptomyces coelicolor A3(2) involves the developmentally regulated synthesis of a compound biosynthetically related to polyketide antibiotics.</title>
            <authorList>
                <person name="Davis N.K."/>
                <person name="Chater K.F."/>
                <person name="Bruton C.J."/>
            </authorList>
            <dbReference type="PubMed" id="2077356"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1990.tb00545.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="X55942">
        <property type="protein sequence ID" value="CAA39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S11978">
        <property type="entry name" value="S11978"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629456.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030169.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P23159"/>
    <dbReference type="SMR" id="P23159"/>
    <dbReference type="STRING" id="100226.SCO5314"/>
    <dbReference type="GeneID" id="1100754"/>
    <dbReference type="KEGG" id="sco:SCO5314"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5400"/>
    <dbReference type="eggNOG" id="ENOG50332TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2207266_0_0_11"/>
    <dbReference type="OMA" id="WRSPKDA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000205353" description="Uncharacterized protein SCO5314">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <sequence length="111" mass="12407" checksum="CD01A94BED3F8F35" modified="1991-11-01" version="1">MHHTLIVARMAPGAAPDIAKVFAESDSGELPHLVGVNRRSLFEFGDGVYLHLIESDEDPAPTIGRLTGHPEFRQVSERLEPYVSAYDPATWRGPKDAMARCFYRWERTPAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-02" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>P60312</accession>
    <accession>O86774</accession>
    <accession>P72404</accession>
    <name>RPOA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">SCO4729</name>
        <name type="ORF">SC6G4.07</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Nucleic Acids Res." volume="24" first="4565" last="4571">
            <title>Molecular analysis of RNA polymerase alpha subunit gene from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Cho E.-J."/>
                <person name="Bae J.-B."/>
                <person name="Kang J.-G."/>
                <person name="Roe J.-H."/>
            </authorList>
            <dbReference type="PubMed" id="8948650"/>
            <dbReference type="DOI" id="10.1093/nar/24.22.4565"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="X92107">
        <property type="protein sequence ID" value="CAA63080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35558">
        <property type="entry name" value="T35558"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628887.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003966937.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P60312"/>
    <dbReference type="SMR" id="P60312"/>
    <dbReference type="STRING" id="100226.SCO4729"/>
    <dbReference type="GeneID" id="1100170"/>
    <dbReference type="GeneID" id="63982151"/>
    <dbReference type="GeneID" id="67399260"/>
    <dbReference type="KEGG" id="sco:SCO4729"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4800"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_11"/>
    <dbReference type="InParanoid" id="P60312"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="PhylomeDB" id="P60312"/>
    <dbReference type="PRO" id="PR:P60312"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175389" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="243"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA63080." evidence="2" ref="1">
        <original>R</original>
        <variation>S</variation>
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA63080." evidence="2" ref="1">
        <original>Q</original>
        <variation>E</variation>
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA63080." evidence="2" ref="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="340" mass="36696" checksum="DD288188FAF08807" modified="2004-02-02" version="1">MLIAQRPSLTEEVVDEFRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDLILNIKQLVVSSEHDEPVVMYLRKQGPGLVTAADIAPPAGVEVHNPDLVLATLNGKGKLEMELTVERGRGYVSAVQNKQVGQEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLIVDVETKQAMRPRDAMASAGKTLVELFGLARELNIDAEGIDMGPSPTDAALAADLALPIEELELTVRSYNCLKREGIHSVGELVARSEADLLDIRNFGAKSIDEVKAKLAGMGLALKDSPPGFDPTAAADAFGADDDADAGFVETEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKN8</accession>
    <name>Q7AKN8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="5" type="ordered locus">SCO2389</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626635.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976417.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKN8"/>
    <dbReference type="STRING" id="100226.SCO2389"/>
    <dbReference type="GeneID" id="1097823"/>
    <dbReference type="KEGG" id="sco:SCO2389"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2430"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_6_11"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="PhylomeDB" id="Q7AKN8"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="82" mass="8917" checksum="064B356BC19145DD" modified="2012-05-16" version="1">MAATQEEIVAGLAEIVNEIAGIPVEDVKLDKSFTDDLDVDSLSMVEVVVAAEERFDVKIPDDDVKNLKTVGDATKYILDHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API2</accession>
    <name>Q7API2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative acyl carrier protein, MmyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mmyA</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639844.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039536.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095317"/>
    <dbReference type="KEGG" id="sco:SCP1.234"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8181"/>
    <dbReference type="HOGENOM" id="CLU_108696_3_2_11"/>
    <dbReference type="InParanoid" id="Q7API2"/>
    <dbReference type="PhylomeDB" id="Q7API2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC36760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="82" mass="8774" checksum="97DF245E00D47C00" modified="2012-05-16" version="1">MTESTVARIIAIICEHFDTGDTEVSAATDFESLEFDSLVLVELAVILTREFGVEVTDDELADGRTIGEAAAVVARKSTALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK26</accession>
    <name>Q8CK26_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1511</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAD55281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733536.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027820.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1511"/>
    <dbReference type="GeneID" id="1096937"/>
    <dbReference type="KEGG" id="sco:SCO1511"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1520"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024630_1_0_11"/>
    <dbReference type="InParanoid" id="Q8CK26"/>
    <dbReference type="OMA" id="DELWHRF"/>
    <dbReference type="PhylomeDB" id="Q8CK26"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="355" mass="40247" checksum="6DCDAB469D001C2E" modified="2003-03-01" version="1">MSSDPWGRVDETGTVYVRTADGEKVVGSWQAGSPEEALAYFERKYEGLVVEIGLLEKRVKTTDLSAKDAQTAVDHLREQVDAHHAVGDLEALRARLDQLVALVETRREERKAQRAKQSDEARGAKEALVAEAEELARSDQWRAAGERLRSLVDTWKGLPRLDRKSDDELWHRFSHARSAFSKRRKQHFAQLDAQREEARRIKERLVSEAEALSNSTDWGPTAARYRDLMSEWKAAGRAQREHEDDLWNRFRGAQDVFFAARSSVFAERDAEQSENLKLKEELVTEAEKLVPVTDLKSARAAFRSVNERWEAIGHVPRDARPKSRGGCTRSSGPSRRPRRPSGAGPTPRHARVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK67</accession>
    <name>Q8CK67_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transmembrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0152</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAD55426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733492.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026887.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0152"/>
    <dbReference type="GeneID" id="1095576"/>
    <dbReference type="KEGG" id="sco:SCO0152"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.128"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_3_11"/>
    <dbReference type="InParanoid" id="Q8CK67"/>
    <dbReference type="OMA" id="VICLMLC"/>
    <dbReference type="PhylomeDB" id="Q8CK67"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043879">
        <property type="term" value="F:glycolate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006847">
        <property type="term" value="P:plasma membrane acetate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAD55426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="536" mass="54428" checksum="D7484A8F62F7E8CA" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IU0</accession>
    <name>Q93IU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BldKD, putative ABC transporter intracellular ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5115</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629265.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973862.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5115"/>
    <dbReference type="TCDB" id="3.A.1.5.36">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100556"/>
    <dbReference type="KEGG" id="sco:SCO5115"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5198"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="Q93IU0"/>
    <dbReference type="OMA" id="RVNVMYL"/>
    <dbReference type="PhylomeDB" id="Q93IU0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
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            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
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        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC44322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="353" mass="38204" checksum="6C920775F4E1FC47" modified="2001-12-01" version="1">MTTQTKPEEAPAAAAGDAFLSVRDLKVHFSTEGGVVKAVDGLSFDLERGKTLGIVGESGSGKSVTNLAVLGLHDRRRTAIDGSITLDGQELTDASEKQLEKLRGKKMAMIFQDALTALSPYYTVGRQIAEPFMKHNGASKKDARVRAIDLLQKVGIPHPQKRVDDYPHQFSGGMRQRAMIAMALSCNPDLLIADEPTTALDVTVQAQILDLLKDLQQEFGSAIIMITHDLGVVGNMADDIMVMYAGRAVERGTVREVLKSPQHPYTWGLLSSMPNLTSDVDEPLMPIPGSPPSLMNPPSGCAFHPRCGFTDLVSGERCSGERPTLPHGRAAACHLTGDQRQQVFIEKIQPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RT0</accession>
    <name>Q93RT0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAC37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630408.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972615.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6311"/>
    <dbReference type="GeneID" id="1101752"/>
    <dbReference type="KEGG" id="sco:SCO6311"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6425"/>
    <dbReference type="eggNOG" id="ENOG5032UCF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718392_0_0_11"/>
    <dbReference type="OMA" id="GVWKYRQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="15042" checksum="D8BCEC818E1220CE" modified="2001-12-01" version="1">MIRQETAWVLFAAGVIFLAALFLGVWKWQQSMSSPDGTAHRYVNVAHNSALLYSFATSAVVAPLVQFSGWPSAVNIIAAAAVVGMFVVTIANYVRLGIEGRTDNQMRDRKTSLRGVRETLIIGEIGGTAVLLTGFASAQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q93S00</accession>
    <name>RL333_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L33 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmG3</name>
        <name type="synonym">rpmG2</name>
        <name type="ordered locus">SCO0570</name>
        <name type="ORF">SC5G5.02c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC39632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624883.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978292.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93S00"/>
    <dbReference type="SMR" id="Q93S00"/>
    <dbReference type="STRING" id="100226.SCO0570"/>
    <dbReference type="GeneID" id="1095993"/>
    <dbReference type="KEGG" id="sco:SCO0570"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.551"/>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:large ribosomal subunit"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000170243" description="50S ribosomal protein L33 3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="54" mass="6153" checksum="E5F48EB1BC492CAC" modified="2001-12-01" version="1">MARSTARPVVKLKSTAGTGVTYVTRKNRLNDPDRLVLRKYDPVAGEHVPFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD60</accession>
    <name>Q9AD60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.90c</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639663.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039389.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095168"/>
    <dbReference type="KEGG" id="sco:SCP1.90c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8038"/>
    <dbReference type="HOGENOM" id="CLU_105030_2_0_11"/>
    <dbReference type="InParanoid" id="Q9AD60"/>
    <dbReference type="OMA" id="CPDEEMF"/>
    <dbReference type="PhylomeDB" id="Q9AD60"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="25621" checksum="BE8409C1FA578203" modified="2001-06-01" version="1">MSTYDTAVLDDTLVSCLSQLIGAEHIDTLTLEGRFEITRIAAALSGRPGPAPRAILMSGLQGSGKTTLARALEAAGFRRLCPDEEMFRRYGHYGRDFPRGEFRVREAPVLKDIALELQELLTAGHEVVVDHGFWTREERAQWAMTVMEAGGKPVLIYLPVPHEVRWDRIRKRNEQSLVDANSIEFSEEDLLRHAGRFSPPTDDEPHIVYDGQPDSVLADIQLSRHFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF4</accession>
    <name>Q9EWF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase beta chain NarH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629100.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029969.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4948"/>
    <dbReference type="GeneID" id="1100389"/>
    <dbReference type="KEGG" id="sco:SCO4948"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5028"/>
    <dbReference type="eggNOG" id="COG1140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_11"/>
    <dbReference type="InParanoid" id="Q9EWF4"/>
    <dbReference type="OMA" id="TWGANWD"/>
    <dbReference type="PhylomeDB" id="Q9EWF4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="548" mass="59848" checksum="3A483D2A9B35039B" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2P7</accession>
    <name>Q9F2P7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3103</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627321.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028767.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3103"/>
    <dbReference type="GeneID" id="1098537"/>
    <dbReference type="KEGG" id="sco:SCO3103"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3166"/>
    <dbReference type="eggNOG" id="ENOG50349MT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118601_0_0_11"/>
    <dbReference type="OMA" id="RRPRDWW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC09544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21808" checksum="DC089C01DD44C1AC" modified="2001-03-01" version="1">MHGHGYAPPPPPRRPRTAVLVLSRVFFVALALLSIGFLAWISTLYAAIVSRRPRDWWVFAATAAALVISFCFLATDDTDDFSTPAGTTGMIILLLNACVCAGYFLYADISHHRRPPHPGHVVAMPPPLAAGYGHPQPSYPYTPPPAAPVQTPVPPYQAAPPQHPPAPARIDQVRAELDELSDYLRNHDGRDGRDGGHRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2S3</accession>
    <name>Q9F2S3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4466</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628632.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974515.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4466"/>
    <dbReference type="GeneID" id="1099906"/>
    <dbReference type="KEGG" id="sco:SCO4466"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4536"/>
    <dbReference type="HOGENOM" id="CLU_1634396_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC08373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="162" mass="17639" checksum="191F4B4D8EE27364" modified="2001-03-01" version="1">MSRLKDGRFYGYLRHPLPHERDTIVDAVVTSYVKAAGPVRQRAIDDLDTRGASVLSVYGQRMASAAVRAGSVDTLRRGLVAVGMAQARLRDARENLYPLAALHDAASLLGTSLRNLITEVSDSLPTSAVEELRAFDQRQEQDKSLAAMGLRRLGGGQTLLYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F323</accession>
    <name>SYD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">SCO3795</name>
        <name type="ORF">SCAC2.03c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="1"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC08476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627985.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029239.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F323"/>
    <dbReference type="SMR" id="Q9F323"/>
    <dbReference type="STRING" id="100226.SCO3795"/>
    <dbReference type="GeneID" id="1099231"/>
    <dbReference type="KEGG" id="sco:SCO3795"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3857"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_11"/>
    <dbReference type="InParanoid" id="Q9F323"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="PhylomeDB" id="Q9F323"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000110952" description="Aspartate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="532"/>
            <end position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="587" mass="66002" checksum="BE6381432C8D9BC3" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3F2</accession>
    <name>Q9F3F2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7605</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631646.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031775.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7605"/>
    <dbReference type="GeneID" id="1103043"/>
    <dbReference type="KEGG" id="sco:SCO7605"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7721"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F3F2"/>
    <dbReference type="OMA" id="GGMEYAM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176680" evidence="1">
        <location>
            <begin position="41"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="334"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="473" mass="51210" checksum="F2D7679CD20F4B1F" modified="2001-03-01" version="1">MSPLGTFLPAPWSHPAGRHLFVVLLVLLLAVGTPAGVSGAAAGGGGSAATPDRARYDVDLRSDADGGRWTGRQRVSFRNASERPLREVYLRLWGNGEDGCGTPGTPGAPGVPSPVVVSGLRGGTADPLTVNCTALRIALPKPLARGERASVAFDVSVTVPDRNARFGREGAFRFLGNALPVLAVHDAAGWHLDPYVAVGESFYALAGDFRVRLDHPSDMAVPATGRTRTRPGAPGRSVTLSLAERVRDFAWAAGPFRTAAQTTPGGVRVKSFWAPGTPAAGVRLARAEAVAAVDRFGREFGRYPYGEVDLVMTSGFGGGMEYPGLVLLGTTEEGNAVVHELAHQWWYGIVGNDEYASPWLDESFAQYANFRFYGLETRDCWSDVYWPDDGAELTASMDYWSRHRGEYHLVYTAGPCALADLERTLGADAMARLLERYARDHWYGVSTTEDFKRAAQSMTDEDLGPFWESRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L7</accession>
    <name>Q9F3L7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5247</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629393.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030134.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5247"/>
    <dbReference type="GeneID" id="1100688"/>
    <dbReference type="KEGG" id="sco:SCO5247"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5331"/>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F3L7"/>
    <dbReference type="OMA" id="YHFGGYA"/>
    <dbReference type="PhylomeDB" id="Q9F3L7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019148">
        <property type="term" value="F:D-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC05972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="302" mass="32002" checksum="84D211C09F6E925B" modified="2001-03-01" version="1">MTGTDTRQLAALRPRLPSPLHEVADGRFERHGVRLLLKRDDLIHPELVGNKWRKLAPNLATADGRTVVTFGGAYSNHLRAAAAAGRLLGLPTVGVVRGQELAGLPLNPSLARCAADGMRLHFVDRSTYRRKSEPETLAALLRAAGAEGAVVVPEGGSNADAVRGCRALGEELGTHADVAAVACGTGGTLAGLAAGLPRGRRALGIPVLKGGFLEGDIRRLQERAFGGPRGDWSLEDRFHHGGYARTTPGLDAFAADFEHRHGLPVERVYVAKMLYALLTLTEEGAFPRGTTLAAVVTGRPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBY8</accession>
    <name>Q9FBY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7194</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631252.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031499.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7194"/>
    <dbReference type="GeneID" id="1102632"/>
    <dbReference type="KEGG" id="sco:SCO7194"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7293"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_2_1_11"/>
    <dbReference type="InParanoid" id="Q9FBY8"/>
    <dbReference type="OMA" id="CPVHVAD"/>
    <dbReference type="PhylomeDB" id="Q9FBY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="28270" checksum="86E7EB767B8DB290" modified="2001-03-01" version="1">MTVLVVGGSGFLGTELVRQASAAGHRVAATFATRPCDGPEATWHEVDLRDGARVEEVVASLAPCVVINASSGSADWAVTAEGSVRLAMTAVKYDCRLVHVSSDAVFSGSRVHYDESCLPDPVTPYGAAKAAAETGIRLLAPAAVIARTSLIIGGIQSEHVRLVHDLATGSRTGALFTDDVRCPVHVEDLAAALLELAFTGACGVHHLAGKDAVSRHGLGVLIAQRDGLDASRLPEGLRAGTSLSGALDVRLDSRATRAKLRTRVRGVHEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBZ3</accession>
    <name>Q9FBZ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7189</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631247.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031494.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102627"/>
    <dbReference type="KEGG" id="sco:SCO7189"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7288"/>
    <dbReference type="HOGENOM" id="CLU_175454_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FBZ3"/>
    <dbReference type="OMA" id="ALDQCWD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="87" mass="9955" checksum="F0008D1049B11D4B" modified="2001-03-01" version="1">MTGSEADTEGQILGRINDMIRQEKDLREQLAEQVIDESAEHARLARLEVELDRCWDLLRQRKARVAAGQDPDIVHVRPASQVEDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC94</accession>
    <name>Q9FC94_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1219</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625508.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977612.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1219"/>
    <dbReference type="GeneID" id="1096642"/>
    <dbReference type="KEGG" id="sco:SCO1219"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1218"/>
    <dbReference type="eggNOG" id="ENOG5032YM2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136228_1_0_11"/>
    <dbReference type="OMA" id="GHTYVRS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC01501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="131" mass="14971" checksum="8B7323F15CF44799" modified="2001-03-01" version="1">MPQDPTERRVTVTGPPRRTVPPARLRSRGRHPQATGHYRPRTEIDEQTTLGHTYVRSLMRSQLRAGLTALAVLGLLVGPLPLLFAALPDARRLEWAVLGFGLYAPLVLLARWYVRRAERNERDFVRLVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCD0</accession>
    <name>Q9FCD0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1237</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977594.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1237"/>
    <dbReference type="GeneID" id="1096660"/>
    <dbReference type="KEGG" id="sco:SCO1237"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1236"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160748_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCD0"/>
    <dbReference type="OMA" id="MAYEIPV"/>
    <dbReference type="PhylomeDB" id="Q9FCD0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="10014" checksum="1C26460A07A86463" modified="2001-03-01" version="1">MAYEIPVTQARAELADLINRVVYGGERVVVTRHGKPLVALVSAADLARLEELRESPDAQVIASVAGVHDASAASAPREHHRFGIAAEHRGPDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCI7</accession>
    <name>Q9FCI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5201</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629349.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973775.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5201"/>
    <dbReference type="GeneID" id="1100642"/>
    <dbReference type="KEGG" id="sco:SCO5201"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5284"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089568_1_1_11"/>
    <dbReference type="InParanoid" id="Q9FCI7"/>
    <dbReference type="OMA" id="WPLQRVS"/>
    <dbReference type="PhylomeDB" id="Q9FCI7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="152" mass="16256" checksum="39E43C3F7E1E7609" modified="2001-03-01" version="1">MATTNDHPGERAAADPVKLIGIRETPLSVDEVFGAVGDDASGGTALFVGTVRNHDGGTDVDRLGYSCHPSAEAEMRRIAEKVVAEYPVRALAALHRVGDLEVGDLAVVVAVSCPHRGEAFDACRKLIDDLKHEVPIWKHQTFSDGTEEWVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCL8</accession>
    <name>Q9FCL8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7796</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631827.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031920.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7796"/>
    <dbReference type="GeneID" id="1103234"/>
    <dbReference type="KEGG" id="sco:SCO7796"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7911"/>
    <dbReference type="eggNOG" id="ENOG502ZRFF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107599_0_0_11"/>
    <dbReference type="OMA" id="LFFHEVE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="219" mass="24958" checksum="28712E0F8385ADC7" modified="2001-03-01" version="1">MGWAFGLIAEDPVARGAALVHLAEAQRKVAEALARSNETWLLTRPLEADEQYREPAFLHARRKYQQAQRCSLPDGVWGGPANGDLATWPGLPYVLLFLEWEAKYPLEWTQHAKAWGTKQSLIREVARARHEEAIKAKLTDLVEIVVHRAYRCKDREYVRVARAVDSADLRDRLGRATESDSPWARCHAGYVLWLLDRPDLPNTRRVWQTWVAGEAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M1</accession>
    <name>Q9K3M1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ROK family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1039</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625334.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027535.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1039"/>
    <dbReference type="GeneID" id="1096462"/>
    <dbReference type="KEGG" id="sco:SCO1039"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1034"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_2_11"/>
    <dbReference type="InParanoid" id="Q9K3M1"/>
    <dbReference type="OMA" id="PEGRPCH"/>
    <dbReference type="PhylomeDB" id="Q9K3M1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB96024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="412" mass="41832" checksum="F538ECE182975955" modified="2000-10-01" version="1">MSGKADPRAAGEGTTSRTRLDRGRGALGPALELVHTGRAPTRAVLTAELGVTRATAGAVAAELEALGLIRVDARPGAAGGSQGRPSHRLSVAEDGPVALAAQIHADGFRAALVGLGGRIVATAPGCEVVDADPAKVLGSVVEAGAELLRETGRRCVGAGLAVPSAVAEPEGLALNPLHLAWPAGAPVREIFARQVRAAGIQGPAFTGNDVNLAALAEHRHGAGRGARDLLCVATGHRGVGGALVLDGRLHTGSSGLALEVGHLAVNPEGRPCHCGSRGCLDVETDPLAFLTAAGREPGPEVSLLQQSYDLIREHYADPAVRTATETLIDRLGLGLAGLVNILNPDRIILGGLHRALLDADPGRLRAVVAGRSLWGQSGGVPILPCGLDHNSLVGAAELAWQPVLDDPLGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Q0</accession>
    <name>Q9K3Q0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative MarR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1098</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625392.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027573.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1098"/>
    <dbReference type="GeneID" id="1096521"/>
    <dbReference type="KEGG" id="sco:SCO1098"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1095"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_5_11"/>
    <dbReference type="InParanoid" id="Q9K3Q0"/>
    <dbReference type="OMA" id="QWQQVHP"/>
    <dbReference type="PhylomeDB" id="Q9K3Q0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="191" mass="20002" checksum="2A23E9DA06F266A6" modified="2000-10-01" version="1">MTATDGGAHDGGVGSGSGDGGTGPGGDTVAAVVRQWRAVHPDLDTGPMEIIGRINRCAALLQQAEDAPLRRAGLSRAEFDLLGALRRTGHELTPGELARETFSSGAAVTKRLKQLTERGLVERRGDTRDRRVAHVRLTDAGRDLVDGILPEQLAYESAVLSGVAGPRQDELAALLGGLLGQLEGRLDALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K403</accession>
    <name>Q9K403_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fatty acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1330</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625615.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027725.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1330"/>
    <dbReference type="GeneID" id="1096753"/>
    <dbReference type="KEGG" id="sco:SCO1330"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1333"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065806_0_0_11"/>
    <dbReference type="OMA" id="FRIRRCA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="360" mass="38788" checksum="A659448A3777F218" modified="2000-10-01" version="1">MCLTFRIRRCARAESPAPSHRTVRLRAFNDRASRRVRLRIPRKRPPGGAYVHLRMAGAYVIALPHLPILPTSPRPEVTCGGRVVPAPDEGGRRELLPSRHRMRPLVWKRIDVSNLATALVDMAQRQPQGLAMQDEKTVLTYADLDDLSARAAGGLRAHGVRPGGRVGLRLPCSLAFAVLYFGALRTGAVAVPVYPRTRTPTVDPCHEACGARLVFTAPDETTSREMRKSDTTLIPVGPDFLDQVTFWPRHTGVVHRWDHDPAIAVRAPDTPSGAQEALLSHRMLRTAALTARTLIDNTASHVDPAQVPPFSASGTTHGLNAVILIGACLLTPGGHAAVSDNGFPDAADCPAAPPPSGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K424</accession>
    <name>Q9K424_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative bifunctional protein (ATP/GTP binding protein/MutT-like)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1075</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625369.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977755.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1075"/>
    <dbReference type="DNASU" id="1096498"/>
    <dbReference type="GeneID" id="1096498"/>
    <dbReference type="KEGG" id="sco:SCO1075"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1072"/>
    <dbReference type="eggNOG" id="COG0645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799046_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K424"/>
    <dbReference type="OMA" id="KPGWEFP"/>
    <dbReference type="PhylomeDB" id="Q9K424"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="347" mass="37680" checksum="4F3093E3D868145A" modified="2000-10-01" version="1">MTVVWINGAFGAGKTTTARELIELIPNSTLFDPEVVGGALAHLLPPKRLAEVGDFQDLPIWRRLVIDTAAALLADLGGTLVVPMTLLRQEYRDEIFGGLAARRIEVRHILLAPAETILRERIASREVPRDLPDGELRTRQWSYDHIEPYRAALASWLTADAHPVDTGALTPYEAAARVAEAVGSGAVPACEIVQTPEPTGETVAAGVLLFDERDRVLLVDPTYKPGWEFPGGVVEPGEAPARAGMREVAEETGLSLRDVPALLVVDWEPPAPPAYGGLRLLFDGGRLDAADAGRVLLPGPELRDWRFATEDEAAGLLPPVRYERLRWALRARERGAAHYLEAGTPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K431</accession>
    <name>Q9K431_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB95287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625362.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027556.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1068"/>
    <dbReference type="GeneID" id="1096491"/>
    <dbReference type="KEGG" id="sco:SCO1068"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1065"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070584_1_0_11"/>
    <dbReference type="OMA" id="RQAHETT"/>
    <dbReference type="PhylomeDB" id="Q9K431"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="143"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26645" checksum="BC02874A7485224A" modified="2000-10-01" version="1">MKTAAYVEILDREGALLAEAAETAGSDAEVPTCPGWRVRDLLRHTGMVHRWATAFVAEGHTGPRRADDPPALDGARLVSWFRDGHARLVDTLTGAAPEVRCWQFLPAPSPLAFWARRQAHETTVHRLDAESACGGGATGIGVDFAVDGIDELLCAFHARPKSAVRTEEPRTLRVRATDAADAVWTVRLSAQPPVRVREAAGTADCELSGPAAHLYPALWNRRPFPEVTGDGSLAALWRERSGVTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K457</accession>
    <name>Q9K457_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative polysaccharide lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7228</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB94651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631284.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971917.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7228"/>
    <dbReference type="CAZy" id="CBM35">
        <property type="family name" value="Carbohydrate-Binding Module Family 35"/>
    </dbReference>
    <dbReference type="CAZy" id="PL9">
        <property type="family name" value="Polysaccharide Lyase Family 9"/>
    </dbReference>
    <dbReference type="GeneID" id="1102666"/>
    <dbReference type="KEGG" id="sco:SCO7228"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7328"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034062_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K457"/>
    <dbReference type="OMA" id="QFWSGSN"/>
    <dbReference type="PhylomeDB" id="Q9K457"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="2">
        <location>
            <begin position="59"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB94651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="554" mass="57517" checksum="9F19D380DB57DFFB" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K486</accession>
    <name>Q9K486_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5237</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629384.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030129.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5237"/>
    <dbReference type="GeneID" id="1100678"/>
    <dbReference type="KEGG" id="sco:SCO5237"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5320"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="InParanoid" id="Q9K486"/>
    <dbReference type="OMA" id="GQWIDAT"/>
    <dbReference type="PhylomeDB" id="Q9K486"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="250" mass="25506" checksum="94958BC10C82D373" modified="2000-10-01" version="1">MGVLAGRTALVTGASRGIGRGIAERLGRDGARVAVHYGRNEAAAKETVAAIEAGGGSAFTIRADLGAPGAAEALWEQFDRHADGLDVLVNNAGIGNTRPIGEIGEAEYDAVFTVNVKAPFFILKHGMGRLRDGGRVVNISSGLARTAVMPDNMAYAMTKGALDVFSRDLSKVLGTRGITVNSVAPGIIDTDNTAGMLHGSEGGWERAAAFSALGGVGTAAEVADVVAFLASHGGRWVTGSWVDATGGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4A4</accession>
    <name>Q9K4A4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5215</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629362.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973757.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5215"/>
    <dbReference type="ESTHER" id="strco-SCO5215">
        <property type="family name" value="NLS3-Tex30"/>
    </dbReference>
    <dbReference type="GeneID" id="1100656"/>
    <dbReference type="KEGG" id="sco:SCO5215"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5299"/>
    <dbReference type="eggNOG" id="COG3571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072792_3_0_11"/>
    <dbReference type="InParanoid" id="Q9K4A4"/>
    <dbReference type="OMA" id="HSFKPRK"/>
    <dbReference type="PhylomeDB" id="Q9K4A4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026555">
        <property type="entry name" value="NSL3/Tex30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13136">
        <property type="entry name" value="PTHR13136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="211" mass="21847" checksum="859931E510229EB6" modified="2000-10-01" version="1">MTEAVETDAGPARITWHRAKQPRLVLAVSHGAGGGIEARDLKALAAALPAHGVSVALVEQPWRVAGRKLAPAPKTLDTGWRGVWPALAAPGLPVISGGRSAGARVACRTAGELGARAVLALSFPLHPPGRPEKSRADELLGAGVPTLVVQGGNDPFGRPHEFPEAPGGTYDLIEVPYGDHGFAVPKRAEISQERALELITDGVAQWAGSLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-06" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4A7</accession>
    <name>AROA1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase 1</fullName>
            <ecNumber evidence="1">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase 1</fullName>
            <shortName evidence="1">EPSP synthase 1</shortName>
            <shortName evidence="1">EPSPS 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroA1</name>
        <name type="synonym">aroA2</name>
        <name type="ordered locus">SCO5212</name>
        <name type="ORF">SC7E4.09c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB94597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629359.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973760.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4A7"/>
    <dbReference type="SMR" id="Q9K4A7"/>
    <dbReference type="STRING" id="100226.SCO5212"/>
    <dbReference type="GeneID" id="1100653"/>
    <dbReference type="KEGG" id="sco:SCO5212"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5296"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4A7"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="PhylomeDB" id="Q9K4A7"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000088302" description="3-phosphoshikimate 1-carboxyvinyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="1">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="438" mass="45851" checksum="8373B568E6C5C353" modified="2000-10-01" version="1">MTVNPTHTALWPAPHASGAVDATVHVPGSKSVTNRALVLAALASEPGWLRRPLRSRDTLLMAEALRTLGVEIEEGVGPEGTGEFWRVIPAGLRGPATVDVGNAGTVMRFLPPVATLADGAVRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGGGALEGGPVEIDASSSSQFVSALLLSGPRFNQGVEVRHTGSALPSMPHIRMTVDMLRAVGAQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKVVIPDWPSRTTQPGDRLREIFTDMGGSCELTDFGLVFTGSGAIHGIDVDLSEVGELTPGIAAVAALADSPSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRRLHGGVFHTYDDHRMATAGAVLGLAVEGVQIENVATTAKTLPDFPDLWTGMLGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4C3</accession>
    <name>NUCS_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease NucS</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nucS</name>
        <name type="ordered locus">SCO5388</name>
        <name type="ORF">2SC6G5.32c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB94559" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94559.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629527.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973608.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007387684.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4C3"/>
    <dbReference type="SMR" id="Q9K4C3"/>
    <dbReference type="STRING" id="100226.SCO5388"/>
    <dbReference type="GeneID" id="1100828"/>
    <dbReference type="KEGG" id="sco:SCO5388"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5469"/>
    <dbReference type="eggNOG" id="COG1637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069350_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4C3"/>
    <dbReference type="PhylomeDB" id="Q9K4C3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000155687" description="Endonuclease NucS">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="223" mass="24601" checksum="67632C365191290A" modified="2003-10-31" version="2">MRLVIARCSVDYAGRLTAHLPSAPRLILVKADGSVSIHADDRAYKPLNWMSPPCALKEGTGEEEGVWTVVNKAGEKLIITMEEILHDSSHELGVDPGLIKDGVEAHLQELLADRIDTLGEGYTLIRREYMTAIGPVDILCRDAQGGTVAVEIKRRGEIDGVEQLTRYLELLNRDPHLAPVRGVFAAQEIKPQARVLATDRGIGCQVLDYDALRGIEDDKLRLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4F9</accession>
    <name>NBLIK_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferric nitrobindin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO4179</name>
        <name type="ORF">SCD66.16</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks the conserved His residue that binds heme iron in the nitrobindin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628355.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974791.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4F9"/>
    <dbReference type="SMR" id="Q9K4F9"/>
    <dbReference type="STRING" id="100226.SCO4179"/>
    <dbReference type="PRIDE" id="Q9K4F9"/>
    <dbReference type="GeneID" id="1099619"/>
    <dbReference type="KEGG" id="sco:SCO4179"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4243"/>
    <dbReference type="eggNOG" id="COG3485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085483_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K4F9"/>
    <dbReference type="OMA" id="EKCNFGQ"/>
    <dbReference type="PhylomeDB" id="Q9K4F9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000356953" description="Ferric nitrobindin-like protein">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="191" mass="21694" checksum="CD5A6E32FDE9D8A1" modified="2000-10-01" version="1">MIEIPSDLHKDLVPLVFLLGDWAGAGVHDFPGAEKCNFGQEVSFTHDGRDFLEYQSHTWVLDNDGNKVRPLESEHGFWRIDANRKVEVTMTRDDGVIEIWYGELADQKPQIDLVTDAVARTAASQPYTGGKRLYGYVKSDLMWVGEKQTPEVELRPYMSAHLKKVVTPEDVERWAKALPDDMPDDGIAFFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-26" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXR3</accession>
    <name>PYRC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotase</fullName>
            <shortName evidence="1">DHOase</shortName>
            <ecNumber evidence="1">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrC</name>
        <name type="ordered locus">SCO1486</name>
        <name type="ORF">SC9C5.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625766.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977340.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KXR3"/>
    <dbReference type="SMR" id="Q9KXR3"/>
    <dbReference type="STRING" id="100226.SCO1486"/>
    <dbReference type="GeneID" id="1096912"/>
    <dbReference type="KEGG" id="sco:SCO1486"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1495"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KXR3"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="PhylomeDB" id="Q9KXR3"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000147254" description="Dihydroorotase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <sequence length="428" mass="45271" checksum="FB1ED5EC2326951A" modified="2000-10-01" version="1">MSKTLIRGAKVLGGEPQDVLIDGTVVEAVGTNLSAEGAEVVEADGKVLLPGLVDLHTHLREPGREDSETVLTGTRAAASGGYTNVFAMANTFPVADTAGVVEQVWRLGQESGYCDVQPIGAVTVGLEGAKLAELGAMHESAAGVTVFSDDGKCVHDAVIMRRALEYVKAFNGVVAQHAQEPRLTEGAQMNEGVVSAELGLGGWPAVAEESVIARDVLLAEHVGSRVHICHLSTAGSVEIVRWAKSRGIDVTAEVTPHHLLLTDELVRSYNPVYKVNPPLRTERDVMALREALADGTIDIVATDHAPHPHEDKDCEWAAAAMGMVGLETALSVVQETMVDTGLLDWAGVADRMSFKPAKIGQATGHGRPVSAGEPANLTLVDAAYRGQVDPAGFASRSRNTPYEGRELPGRVTHTWLRGKATLVDGKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYM6</accession>
    <name>Q9KYM6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7359</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB92202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631412.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971784.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7359"/>
    <dbReference type="ESTHER" id="strco-SC9H11.13C">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1102797"/>
    <dbReference type="KEGG" id="sco:SCO7359"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7462"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_3_11"/>
    <dbReference type="InParanoid" id="Q9KYM6"/>
    <dbReference type="OMA" id="FGHADND"/>
    <dbReference type="PhylomeDB" id="Q9KYM6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="251" mass="26643" checksum="7BD144668EC7AFC2" modified="2000-10-01" version="1">MTATAGTALDIPTGDGTADAYLTRPADGGPHPAVLLYMDAFGLRPSLRSMADRLAGAGYTVLVPNVFYRSGRTPVVELPGFIDPRARPEIFERLGPIMRSLTPDLAMRDADAYLRLLAGRPEAADGPVALVGYCMGAALALRTAGTYPDRVAAVAGFHGANLATDGPHSPHLVAGDITAEAYFAHADQDPGMDAEQQERLSAALTAAGVRHRCEVYAGAHHGYTQADTSAYDPEATERHWTALLDLLKRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYY8</accession>
    <name>Q9KYY8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7541</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB90899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631585.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031735.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7541"/>
    <dbReference type="GeneID" id="1102979"/>
    <dbReference type="KEGG" id="sco:SCO7541"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7655"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_2_11"/>
    <dbReference type="InParanoid" id="Q9KYY8"/>
    <dbReference type="OMA" id="WEALPWM"/>
    <dbReference type="PhylomeDB" id="Q9KYY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB90899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="719" mass="76178" checksum="7E50E363F5D71FEB" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ44</accession>
    <name>Q9KZ44_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7088</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631149.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972056.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7088"/>
    <dbReference type="GeneID" id="1102526"/>
    <dbReference type="KEGG" id="sco:SCO7088"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7190"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9KZ44"/>
    <dbReference type="OMA" id="HIHRAMT"/>
    <dbReference type="PhylomeDB" id="Q9KZ44"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="23865" checksum="14CB6D82A28471FD" modified="2000-10-01" version="1">MTIRVLLADDQALLRATFRILIDSDPHMTVVAEAADGQEAVALTLEHRPDVVLMDIRMPGTDGLAATAGICARTDLSGTRVLILTTFEDDENVALALRSGASGFLGKDVGPDVLLAGIRTVAAGDSLLSPTATRALITRFLASPTDDVPLAAPERLALLTEREREVMALAALGKSNQEIADHLVVSPLTVRSHVSRAMTKLNARDRAQLVVIAYQSGLVRPNLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ83</accession>
    <name>Q9KZ83_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO3062</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="e107168" last="e107168">
            <title>Mechanism of the pH-induced conformational change in the sensor domain of the DraK Histidine kinase via the E83, E105, and E107 residues.</title>
            <authorList>
                <person name="Yeo K.J."/>
                <person name="Hong Y.S."/>
                <person name="Jee J.G."/>
                <person name="Lee J.K."/>
                <person name="Kim H.J."/>
                <person name="Park J.W."/>
                <person name="Kim E.H."/>
                <person name="Hwang E."/>
                <person name="Kim S.Y."/>
                <person name="Lee E.G."/>
                <person name="Kwon O."/>
                <person name="Cheong H.K."/>
            </authorList>
            <dbReference type="PubMed" id="25203403"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0107168"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 28-115</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB89434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028744.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="PDB" id="2MJ6">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=28-115"/>
    </dbReference>
    <dbReference type="PDBsum" id="2MJ6"/>
    <dbReference type="SMR" id="Q9KZ83"/>
    <dbReference type="STRING" id="100226.SCO3062"/>
    <dbReference type="GeneID" id="1098495"/>
    <dbReference type="KEGG" id="sco:SCO3062"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3122"/>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_28_11"/>
    <dbReference type="InParanoid" id="Q9KZ83"/>
    <dbReference type="OMA" id="RPRHKRY"/>
    <dbReference type="PhylomeDB" id="Q9KZ83"/>
    <dbReference type="BRENDA" id="2.7.13.3">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040868">
        <property type="entry name" value="DraK_HK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18092">
        <property type="entry name" value="DraK_HK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="209"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB89434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="2MJ6"/>
        </source>
    </evidence>
    <sequence length="424" mass="45482" checksum="EB27875A6F5C6797" modified="2000-10-01" version="1">MRRRLIQSTLAVVLVVIAVFGVSLVIVETRTISSTAQERVDLEAVRLASIVDSRLIGTGSVDEDFLREQIRDARYAVIRIPGEPVVEVGTKPTGDVLQGRATGEEGETVLVEEPRSSVTREVGRTLLIIGLVALLAVIAAVLLAIRQANRLASPLTDLAETAERLGSGDPRPRHKRYGVPELDRVADVLDSSAERIARMLTAERRLAADASHQLRTPLTALSMRLEEITLTDEPETVKEEATIALSQVERLTDVVDRLLTNSRDPRSGSAVTFELDDVIQQQIAEWRPAYRGEGRAIVSSGKRHLTAVGTPGAVAQVLAALIENSLMHGGGTVALRTRVTGNQAVVEVTDEGPGVPGDLGARIFERAISGRNSTGIGLAVARDLAEADGGRLELLQGRPPVFGLFLSRTPPSKKSPGDGDQTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZJ0</accession>
    <name>Q9KZJ0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1155</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625447.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977676.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1155"/>
    <dbReference type="GeneID" id="1096578"/>
    <dbReference type="KEGG" id="sco:SCO1155"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1153"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZJ0"/>
    <dbReference type="OMA" id="TMVEFDD"/>
    <dbReference type="PhylomeDB" id="Q9KZJ0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="137" mass="14417" checksum="76C0A5A711838059" modified="2000-10-01" version="1">MVQNQGLGWLLDDLTARVEHVRHALVLSNDGLVTGASTGLRREDAEHLAAVSSGLHSLAKGSGRHFGAGQVQQTMVEFDDAVLFVTAAGSGSCLCVLSGAEADIGQIAYEMTLLVNRVGEHLDVDARQPGRISPTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZM6</accession>
    <name>Q9KZM6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625689.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027770.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1406"/>
    <dbReference type="GeneID" id="1096832"/>
    <dbReference type="KEGG" id="sco:SCO1406"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1416"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064093_1_0_11"/>
    <dbReference type="OMA" id="HAIGHAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="328" mass="37101" checksum="99FA3AC67C2C9732" modified="2000-10-01" version="1">MLGKLFGKVGERPAADPNALPVPRGRRNGTYPVRALGDTRVLALVEAADAGDWDGVKAALAPFDLGRDHQVLGELADLDGMQDWIGRAAEQDAEHRATALLMSGARHIVWGWEARTTERAANVTREQWRLFHERLEIAEEQLLLAAELRPDWVTPWCRLLTSARGMSLPDDVKRTRYEAALRRDPLDLETHLERVSQLQPRWGGEAGEAMTYAREAFTRAPEGHRLGCVVAMAHIEDWVESDSPSCLDLPYIQRELREAAKRSILHPAYERRPGWQQDFNTFAMALSLAGESIVVQRVFHELGGACTPWPWRYMAQPEKAYARFRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZR1</accession>
    <name>Q9KZR1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2892</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627118.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028649.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2892"/>
    <dbReference type="GeneID" id="1098325"/>
    <dbReference type="KEGG" id="sco:SCO2892"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2951"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029872_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KZR1"/>
    <dbReference type="OMA" id="RYAMIFE"/>
    <dbReference type="PhylomeDB" id="Q9KZR1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="241"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="454" mass="47507" checksum="9F36FAACF4D8E45D" modified="2000-10-01" version="1">MTRGRDGGAGAPPTKHRALLAAIVTLIVAISAAIYAGASADDGSRDHALQAGGRLPRGDAAPASTGAWVGAWATAPAAAEPGTETTGLAGRSVRNVVHTSVGGTGARITLSNLYGQSPLTVTHASIALAAGPDTAAAIADTMRRLTFGGSARVIIPAGGQVMSDTARLAIPYGANVLVTTYSPIPSGPVTYHPQARQTSYLADGDRTADVTAVAYTTPTPYWRYLTALDVLSHEADGTVVAFGDSITDGARSQSDANHRWTDVLAARLHEAAGDGRDTPRYSVVNEGISGNRLLTSRPGRPADNPSGLSRFQRDVLERTNVKAVVVVLGVNDVLNSPELADRDAILTGLRTLVDRAHARGLRVVGATITPFGGYGGYTEARETMRQEVNEEIRSGRVFDTVVDFDKALRDPYDPRRMRSDYDSGDHLHPGDKGYARMGAVIDLAALKGAAPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0E4</accession>
    <name>Q9L0E4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative insertion element IS1652 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4698</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628857.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029823.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4698"/>
    <dbReference type="GeneID" id="1100139"/>
    <dbReference type="KEGG" id="sco:SCO4698"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4769"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_15_0_11"/>
    <dbReference type="InParanoid" id="Q9L0E4"/>
    <dbReference type="OMA" id="CANDGRF"/>
    <dbReference type="PhylomeDB" id="Q9L0E4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="151"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB82066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="339" mass="38909" checksum="32C540533B695CB3" modified="2000-10-01" version="1">MGEGLQVRCGLRHLHRVQEALVVHRNAPLTETGRLRLARCVVEDGWPVRRAAERFQVSHTTASRWARRYRQLGVTGMSDRSSRPHHQPRRTAAAVEEHVLRLRREHRIGPLRLAVRCGIAASTAHRILVRHGLPPLAALDRATGEPVRRYERARPGELVHIDVKKLGRIPDGGGHKTLGRAEGHRSRTNGAGWAYLHTALDDHSRIAYTEDLPDETAPTCAAFLVRATAYFASLGIRIERVLTDNAWAYSKNTWRNTCRDLDISPRWTRPWRPQTNGKVERFHRTLLDEWAYQKPYTSDHERREAFTHWLHWYNYHRPHTGIGGHTPASRGTNLSEQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Q3</accession>
    <name>Q9L0Q3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4238</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628412.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974737.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4238"/>
    <dbReference type="GeneID" id="1099678"/>
    <dbReference type="KEGG" id="sco:SCO4238"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4301"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_2_11"/>
    <dbReference type="InParanoid" id="Q9L0Q3"/>
    <dbReference type="OMA" id="YWRAIDT"/>
    <dbReference type="PhylomeDB" id="Q9L0Q3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="245" mass="26784" checksum="C80FF03AAAF1E34A" modified="2000-10-01" version="1">MTDPNAASRRPVQAVVLAGGQGSRLRPYTDDRPKPMVEIPGTGTPIIGHQLAWLAEEGVTDVVVSCGHLAEVLQKWLESADLPLSVTTVVETEPLGRGGGLRYAAAHLPHPDRSWYATNGDIWTRFSLRDMADFHAERDAVATLALARPRLPWGAVQTDGFGHITDFIEAPPSTFEINAGVYVFSPEFAAMLPERGDHERTTFPRLAREHRLAGFPIPQGSYWRAIDTAKDLTEAARELAALSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Z1</accession>
    <name>Q9L0Z1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1468</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625749.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027802.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1468"/>
    <dbReference type="GeneID" id="1096894"/>
    <dbReference type="KEGG" id="sco:SCO1468"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1477"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011707_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0Z1"/>
    <dbReference type="OMA" id="EMSRQLW"/>
    <dbReference type="PhylomeDB" id="Q9L0Z1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="131"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="774" mass="83436" checksum="88FAE0E62CB2E8F2" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L165</accession>
    <name>Q9L165_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7450</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631498.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031674.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7450"/>
    <dbReference type="GeneID" id="1102888"/>
    <dbReference type="KEGG" id="sco:SCO7450"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7561"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062592_5_2_11"/>
    <dbReference type="InParanoid" id="Q9L165"/>
    <dbReference type="OMA" id="NLVVFAH"/>
    <dbReference type="PhylomeDB" id="Q9L165"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329888" evidence="3">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB76313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="21023" checksum="4B503F5169C78E47" modified="2000-10-01" version="1">MVLCAVALLILAVSLVGGNDTSADSSRPPLPAHPGTTASSAPPATGAADSALPRSKPVRLLIPDIAVDAPFTDLAIGDKGQLQPPPAGDTNLVGWYAKGVSPGEKGTSIIAGHVDTKTSAAVFARLDQLDKGDKFQVRRADGRSATFVVDGLETFAKDEFPSDRVYGDADRPEVRLITCAGDYDHKVKDYTDNLVVFAHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1B3</accession>
    <name>Q9L1B3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1568</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB76088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625845.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027853.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1568"/>
    <dbReference type="GeneID" id="1096999"/>
    <dbReference type="KEGG" id="sco:SCO1568"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1580"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_38_3_11"/>
    <dbReference type="InParanoid" id="Q9L1B3"/>
    <dbReference type="OMA" id="FTHMIVE"/>
    <dbReference type="PhylomeDB" id="Q9L1B3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="189" mass="20724" checksum="123D419504E5000E" modified="2000-10-01" version="1">MGYCCLMAVDREQVLRSAATLLTRKSTATMDEVARAAGLSRATLHRHFAGRDALVRALESLGIAECEAALAAARTDEGPAADAVRRLVREMEPSAALLAFLYTENQLFEGEEQNEGWARIDTGLTELFRRGQESGEFRIDLTPAWLTEALYGLLASGAWAVTEGRVARNDFTHMIVELLLGGALRREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1S8</accession>
    <name>Q9L1S8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative carboxy-terminal processing protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2967</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627191.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975845.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2967"/>
    <dbReference type="GeneID" id="1098400"/>
    <dbReference type="KEGG" id="sco:SCO2967"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3025"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_2_11"/>
    <dbReference type="InParanoid" id="Q9L1S8"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="PhylomeDB" id="Q9L1S8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="374" mass="38344" checksum="FC06C659E7C03EF2" modified="2000-10-01" version="1">MFASVLVAGAASGSLPGTDRKSEPGTARSAAPAGQQARHDDVARAAAEAMADGKSPVEAAERAVSRSGDRWGAVYSEGEYEELEDALDGRYTGVGLSARRERDGRIEVTRVRSGSPAAGAGIREGDRLRSVDGERVDGRPVTEVVSILRGDGEREPAGTAVRLGLERGTRAWTETVRRARLSTDPVTVRTLADGLTVVKVTSFTKGVGEQVREAVARVPSGAGVVLDLRGNSGGLVTEAVTAASAFLDGGLVATYDVDGDQRALHAEAGGDTTRPLVALVDGGTMSAAELLTGALQDRGRAVVLGSRTFGKGSVQMPSRLPGGSVAELTVGHYRTPSGRGVDGTGITPDLEVDPADPGALARARTVLSGLGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1U9</accession>
    <name>Q9L1U9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transporter membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2945</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB72191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627169.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028677.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2945"/>
    <dbReference type="GeneID" id="1098378"/>
    <dbReference type="KEGG" id="sco:SCO2945"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3003"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_11"/>
    <dbReference type="InParanoid" id="Q9L1U9"/>
    <dbReference type="OMA" id="CSFPFVM"/>
    <dbReference type="PhylomeDB" id="Q9L1U9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB72191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="34367" checksum="F4A637F56665DDFF" modified="2000-10-01" version="1">MSSGGVVRGRVRRRRGLSRSSPRPFRGSSSTPWLYLAPALVVLGGLLVYPVYQLGLISFLEYTQAQVSGGEPATFQGFGNYAELFGDGEFWRVLLATVVFAAACVVSTLAVGCALAVLLTRVRAVPRLALMLAGLGAWATPAVTGSTVWLLLFDPDFGPVNRMLGLGDHSWTYGRYSAFLLVLLEVVWCSFPFVMVTVYAGIRAVPSEVLEAAALDGASQWRIWRSVLAPMLRPILVVVTIQSVIWDFKVFTQIYVMTNGGGIAGQNMVLNVYAYQKAFASSQYSLGSAIGVVMLLILLAVTLVYLRLLRRQGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2B0</accession>
    <name>Q9L2B0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO5410</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629549.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030227.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5410"/>
    <dbReference type="GeneID" id="1100850"/>
    <dbReference type="KEGG" id="sco:SCO5410"/>
    <dbReference type="HOGENOM" id="CLU_3277069_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB70640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="41" mass="4565" checksum="7347CE4D10AC64FA" modified="2000-10-01" version="1">MRASASEEVDQVRAVLPYVNHTIRHAPEGCITAELFCGTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2D3</accession>
    <name>Q9L2D3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative nitrite reductase NirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2486</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626728.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028381.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2486"/>
    <dbReference type="GeneID" id="1097920"/>
    <dbReference type="KEGG" id="sco:SCO2486"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2528"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_4_11"/>
    <dbReference type="InParanoid" id="Q9L2D3"/>
    <dbReference type="OMA" id="YGLVEPA"/>
    <dbReference type="PhylomeDB" id="Q9L2D3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="331"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="410" mass="42473" checksum="68760C688FD5648B" modified="2000-10-01" version="1">MTSKTRVVVIGAGLAGVTLARRLGELGTPALTLGDEEHRPYNRVLLAEVLAGRYGPEVIALPAPAGLLRGRVTGIDRAGRTVRCADGSVIAYDTLVLATGSNAVLPPLRGLFTPDHELPEGVHAFRTMDDCLGLSKAVRPGVRAVVIGGGLLGVSAARALAVRGAQVVLAQQSERLMERQLDPAASALVRRHLEGLGVEVHTECRVRDVRSVGGAVRSVEMGDGYALGADLVVLACGVRPRAGLAREAGLAVGKGVLVDDELRTSDPHIRAIGDCAQHADHVYGLAAPALEQAGVLAELLAEGGTATRHYTGTRALTRLTLTGADSPFAPLDLAAFGETDPRPGDDVVQLADATRGTYRKVVVRDDRLVGGVLVGELGTVGALARAWEGAEPLPSDGGPLLHLLTQDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2E6</accession>
    <name>Q9L2E6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2473</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB69761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028371.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2473"/>
    <dbReference type="GeneID" id="1097907"/>
    <dbReference type="KEGG" id="sco:SCO2473"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2514"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_4_11"/>
    <dbReference type="InParanoid" id="Q9L2E6"/>
    <dbReference type="OMA" id="DGPPCCY"/>
    <dbReference type="PhylomeDB" id="Q9L2E6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="819" mass="85763" checksum="7EF0372215EDBDD1" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9R422</accession>
    <accession>Q7AKS5</accession>
    <name>Q9R422_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative anti-sigma factor kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative regulator of sig8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsbA</name>
        <name evidence="4" type="ordered locus">SCO0599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="1998-05" db="EMBL/GenBank/DDBJ databases">
            <title>Isolation and characterization of a sigB gene encoding a putative sigma factor of Streptomyces coelicolor which is highly homologous to Bacillus subtilis SigB sigma factor.</title>
            <authorList>
                <person name="Cho Y.H."/>
                <person name="Lee E.J."/>
                <person name="Roe J.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">M145</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF068267">
        <property type="protein sequence ID" value="AAF23069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624911.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027235.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0599"/>
    <dbReference type="GeneID" id="1096022"/>
    <dbReference type="KEGG" id="sco:SCO0599"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.580"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072253_0_0_11"/>
    <dbReference type="OMA" id="QLVWPGR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MEDS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF23069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="309" mass="32623" checksum="1980A069DDD82D8D" modified="2000-05-01" version="1">MSTATADEAFIHPALFYRSETEYTDRTAAFVREGLAAGEPVAVAVPGPNLELVRAGLGSDARDVTFLDMTEAGRNPGRIIPGVLRAFADAHPRVRVRIVGEPVWAGRSAAEYPACAQHEALINAAFAGRRATILCPYDETRLAADVLADALVTHPTVITEGSERISEGYDWPAVLARYNEPLGRAPDAAALAFGSGELPEARRFAVGLAASLGLSGQRLQDAELAVAELTTNSVVHGGGSGTVAVWAEAGQVVCEVRDAGRLTDPLAGRRPPEHGQIGGRGLLLVHYVADLVRVHTTDEGTAVRFYLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCV7</accession>
    <name>Q9RCV7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0854</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625154.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027393.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0854"/>
    <dbReference type="GeneID" id="1096277"/>
    <dbReference type="KEGG" id="sco:SCO0854"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.846"/>
    <dbReference type="eggNOG" id="COG5222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016726_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RCV7"/>
    <dbReference type="OMA" id="RYNGCPF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="1">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="863" mass="92827" checksum="604C7338D4E9215D" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD83</accession>
    <name>Q9RD83_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ROK family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0794</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625095.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027360.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RD83"/>
    <dbReference type="STRING" id="100226.SCO0794"/>
    <dbReference type="GeneID" id="1096217"/>
    <dbReference type="KEGG" id="sco:SCO0794"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.786"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_11"/>
    <dbReference type="InParanoid" id="Q9RD83"/>
    <dbReference type="OMA" id="WMMEAWQ"/>
    <dbReference type="PhylomeDB" id="Q9RD83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="45128" checksum="70BA4F1410EA4F85" modified="2000-05-01" version="1">MAGRNGRTVRDLRRANRTAVLQRLYFDGPLSRFELGPATGLSSGSVSNVVADLVADGLVEEAGSVDSDGGRPRTLLRVAPASGHMIGVDVGETRVRVELFDLTLTELARAERPLAPQRHDVDVIVGHVRDGIAEVLATAGLPPERLLGAGIGVPGIVEHTADRGAVVHGQTIGWDAVPLEALLRAGSPLPDTVPCLIDNGAKTLGQAEMWFGAGRGARNAVVVLFGSGVGASLVTPEAEQGRAVEWGHLTVRVRGRRCRCGALGCLEAYAGAESLLARWREEGGRVPEGTDEETALTAMLAAAYPADGAAADPVALAVLEETAEYLGAGLSDLINLFQPERILIGGWAGLQLGARFLPAVRRHAVSYALRHPARKVTVDLGRLGPDAVTVGAAILPLADFFARGGRRPEPAPEYPVPAWRTALEERAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIU6</accession>
    <name>Q9RIU6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hydrolase (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0960</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB61926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625257.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027471.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0960"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1096383"/>
    <dbReference type="KEGG" id="sco:SCO0960"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.957"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RIU6"/>
    <dbReference type="OMA" id="VERYACS"/>
    <dbReference type="PhylomeDB" id="Q9RIU6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176885" evidence="4">
        <location>
            <begin position="32"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="5">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB61926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="872" mass="95557" checksum="C5D810DCFC30CF11" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIX4</accession>
    <name>Q9RIX4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0139</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624477.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978737.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0139"/>
    <dbReference type="GeneID" id="1095563"/>
    <dbReference type="KEGG" id="sco:SCO0139"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.116"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148715_1_0_11"/>
    <dbReference type="PhylomeDB" id="Q9RIX4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB58302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="106" mass="11796" checksum="9C1B42C3F585DB9A" modified="2000-05-01" version="1">MQDIRAFVEEYVAAATGPDRERYLGLFRDDAAVHDDGRSLRGLAQVRRWREETPNVDYDLLEVTGTPAACRAVAQISGDFPGSPVTLRFAFERDARGKITVLTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY2</accession>
    <name>Q9RIY2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxiribopirymidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO0183</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36965">
        <property type="entry name" value="T36965"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624519.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026907.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0183"/>
    <dbReference type="GeneID" id="1095607"/>
    <dbReference type="KEGG" id="sco:SCO0183"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.156"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RIY2"/>
    <dbReference type="PhylomeDB" id="Q9RIY2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_7" evidence="6">
        <location>
            <begin position="267"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="415" mass="46494" checksum="854D0C08EED4C1BC" modified="2000-05-01" version="1">MRRIVYLGGLTPRGVPERTLSPHLRSRAEVGPILVRDVLHYLAGAATMPDDIDRAFDVGGPDVPTYREMMRRHATVSGLRRRIIVPAPVLTPGLSSHWVGLVTPVPASIARPLTESLRHEVVCQEHDIARYVPDAPGRPLPFDVALTLALRRVREAQVATRWSSASVPGAPSDPLPTDPDWAGGSLYEDERHLPVDASPEALWKVVEGIGGDNGWYSFPPAWAVRGWLDRFVGGVGLRRGRRDAQRLHPARPVAWRGGRRRGHRRLAGRTGYPVVDAAMRQLRHQGWMHNRARLLVASFLTKTLYVDWRIGARHFLDLLVDGDVVNNQLNWQWAAGTGTDTRPHRVLNPLVQARRFDPDGVYVRRWVPELRSVEGGKVHEPWRLAAAERGELDYPDPLVELADGLARFKHARGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIZ1</accession>
    <name>Q9RIZ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0174</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36956">
        <property type="entry name" value="T36956"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624510.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026901.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0174"/>
    <dbReference type="GeneID" id="1095598"/>
    <dbReference type="KEGG" id="sco:SCO0174"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.147"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078523_0_0_11"/>
    <dbReference type="OMA" id="MSETENG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="34180" checksum="2F1530EABC848E67" modified="2000-05-01" version="1">MGAVSPREAGVRNSFDGEGAVMYAHLGDRLIVESPSTGVTRRDGEIVGLHHDDGTPPYDVRWSDTGDVTLVFPGPDARVNHGAEEAEASQGAPSGVSRGEGVDSSLIAAGAGDLGRRLAAARRRRGLSLEQVARRARMAPQYLAYLETHTADPGFGSLVRLADALGTTYAELQGGGADRPPGQGAALRNPTLRDLDEKECRALLSAHGVGRLALNTPDGPAVFPLNYVVSQGTIAFRTDPDAATAAAVDSEVAFEVDHIDDPMSQGWSVLAVGRCRAVTDPEEVRRLAEKAHTEPWAGGRRTMWLAVETERLTGRRITSVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ07</accession>
    <name>Q9RJ07_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO0158</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36940">
        <property type="entry name" value="T36940"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624494.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026891.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0158"/>
    <dbReference type="DNASU" id="1095582"/>
    <dbReference type="GeneID" id="1095582"/>
    <dbReference type="KEGG" id="sco:SCO0158"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.132"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_8_1_11"/>
    <dbReference type="InParanoid" id="Q9RJ07"/>
    <dbReference type="OMA" id="QHELHRV"/>
    <dbReference type="PhylomeDB" id="Q9RJ07"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="409" mass="43006" checksum="528484C04D25CB4D" modified="2000-05-01" version="1">MKHRIVVLGAGYAGAYVAGTLARRLSRQDTEITVVNAEPDFVQRLRLHQLSAGQAIEAPQLTEVFAGTGIRLRLARVTAVDPERQVVAVADADGGDGHGELGYDTLLYALGSHVTTHGVPGVAEHAFDVAGRPSALRLRKRLDVLSRRDEGGSVLIVGVGLTGIETATEIAESRPGLSVTLIARGELGAQLSAGARRHLRQACDRLGITVLEHTEVEAVEAARVLCADGTALASDATVWTAGFAVSPIAAAGGLEVTETGRIVVDRTMQSVSHPNVYAAGDSAYVVGDNGRPLPMSCASAGYTGMQATAAIVGRLTGRTIPNTKLEYLGNHISLGRRDAILQMVDDEAQAKQNYVGGRKAARIKAGILKMSLWTTSHPTFGLPRRRHHLAPVPNGSADKAIAHSEKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ23</accession>
    <name>Q9RJ23_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO1845</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626113.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976976.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1845"/>
    <dbReference type="TCDB" id="2.A.20.1.6">
        <property type="family name" value="the inorganic phosphate transporter (pit) family"/>
    </dbReference>
    <dbReference type="GeneID" id="1097279"/>
    <dbReference type="KEGG" id="sco:SCO1845"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1869"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ23"/>
    <dbReference type="OMA" id="RMFVAWG"/>
    <dbReference type="PhylomeDB" id="Q9RJ23"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="423" mass="42552" checksum="C74FF0AF43EA032C" modified="2000-05-01" version="1">MESFSLILAIVVVTALAFDFTNGFHDTANAMATTISTGALKPKVAVAMSAVLNLVGAFLSVEVANTISKGLVDETGIRPEVIFAALVGAILWNLLTWLVGLPSSSSHALMGGLIGAAVASAGIGAVNGDVLVTKVLLPAIAAPIVAGLAALLASRMTYSLGRRADGRAAAKGYRAGQIASAGLVSLAHGTNDAQKTMGIITLALIAGGSLAPDSDPPVWVILSAGLAIALGTYLGGWRIIRTMGKGLTDLQPQQGFAAQTSAATVILASSHLGFSLSTTHSVSGAVMGAGLGRKGGVVRWSTATRMFVAWGLTLPAAALVAALAEWVCRAGDWGTALVAVFLIASSFAIWRISRREVVDHTNVVDGGPVDTEGPGQPEPAGVVTTAMAAVSPPPTGATEELAATLPAPATTPDPKAPSAATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJI0</accession>
    <name>Q9RJI0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0559</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB57411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624872.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027205.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0559"/>
    <dbReference type="GeneID" id="1095982"/>
    <dbReference type="KEGG" id="sco:SCO0559"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.540"/>
    <dbReference type="eggNOG" id="COG3178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071279_0_0_11"/>
    <dbReference type="OMA" id="KAHEICF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="78"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB57411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="333" mass="36312" checksum="884FF2861837FD76" modified="2000-05-01" version="1">MLNDTPVTVDRGRYRDTVTPWEEPAWRTEAIGWIEARLAAHGLRPTGRWRVRLRPWSVLLRLCVAGDDAVWFKASPPAGAFEAALTASLARWVPGHVLEPLAVDAARGWSLLPDGGPLFRDVLAREPVDPGDWEELLRQYAAMQHALTSRASEIERLGVPAVPAGAQAGVLDRLDTAPLSARDRAALRQLRPRLLDWCAELTALGVPDSLDHADLHDGQLFRPAPGRFTFFDWGDAVVTQPFSSLAVPARRAAERYGPQVLPRLRDAYLEPWTGEGRTAAQLRRAVSLAWRLSALNRAAAYGRLFPGASGASGAATAAAGARCLLELLDEPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJI9</accession>
    <name>Q9RJI9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0399</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624721.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027084.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0399"/>
    <dbReference type="GeneID" id="1095822"/>
    <dbReference type="KEGG" id="sco:SCO0399"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.375"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056164_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJI9"/>
    <dbReference type="OMA" id="ATRLHWY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB58340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="44113" checksum="08194BE00EFB19B9" modified="2000-05-01" version="1">MREKPLRIGVFGLFGAGNSGNDGSLEAVLDHLRAAHPDAVVDAMCGGPETVATRYGVPATRLNWYRGEYRTASRASAIAAKALGKLVDVFRTAAWVRRHDAVIVPGTGVLETTLPLRPWGFPYSLFLLCLTGRLFGTRVALVSVGAGAIGVRPTRVLTRWSTRLAAYRSYRDDQSRDAMRAMGVNTARDEVYADLVFALPGPSASEPVETRGPVCVGVMDFHGSNDERDVAEEIHRRYLDGTTRFVRALVEEGRPVRLLTGDELDRPVAAAIVDAVGSPLVTVAEAASLADLMKETASADTVVATRYHNLVCALKVGTPTLALSYSGKSDALMAEMGMGAYCHPAREADADRLLEQFRELERRSGPVRRTLCERNLVVARRVEDQFAALTTALFPATDHAHALREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK10</accession>
    <name>Q9RK10_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative iron-siderophore permease transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0496</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36414">
        <property type="entry name" value="T36414"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624813.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027159.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0496"/>
    <dbReference type="TCDB" id="3.A.1.14.13">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1095919"/>
    <dbReference type="KEGG" id="sco:SCO0496"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.476"/>
    <dbReference type="eggNOG" id="COG4779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RK10"/>
    <dbReference type="OMA" id="NTTIPMV"/>
    <dbReference type="PhylomeDB" id="Q9RK10"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033214">
        <property type="term" value="P:siderophore-dependent iron import into cell"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB53326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="368" mass="37547" checksum="8FBC80D0A5F88D31" modified="2000-05-01" version="1">MNGTDMRADGADAAVDVKADVRTSVAPGVRFGGLSFVWRPWVAGVTLLLAVAGFLVFCLSIGVGDFPIALPRVVATVFGGGEQVDRFVIMDLRMPRALAGLVVGVALGVSGALTQSIARNPLASPDVLGITSGAGAVAVFLVTVSGGAATAVADSVGLSAAALAGGLGTGLLVYFMAWRRGIDGFRLILIGISVNAVMQAITTWLLVTADIRDVARAQAWLVGSLDNRSWGEVHVALWCTLVLLVVVASVAFQFKPLHFGDDVAAGLGVRYGTVRAVLLLCAVLLAGVAVSAAGPVPFVALVAPQVAMRLARCPTPPLVASGLVGALLLTGSDLLARTALPVSLPVGVVTAAIGGPFLVYLLVRANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK30</accession>
    <name>Q9RK30_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0686</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624994.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027294.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0686"/>
    <dbReference type="GeneID" id="1096109"/>
    <dbReference type="KEGG" id="sco:SCO0686"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.672"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045539_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RK30"/>
    <dbReference type="OMA" id="KQPKFRW"/>
    <dbReference type="PhylomeDB" id="Q9RK30"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="43563" checksum="F23E49993DEDEDB5" modified="2000-05-01" version="1">MTTTLRKVHASGERFGIFQRNVRADGHTALFGPIQGTADERADAETGNPGGMARLHFPRGGKHTKDATADAPTGERSGEDYGPDAATERAAPDSPTELPGRSWSALLRRVFAEFKDDELTDRAAALTYYGILALFPALLVLVSLLGIAGDSATQEVLDNVKKLAPGSARDVLTNAVEQLQAKAGLGSVLAVVGLVGAVWSASGYVAAFIRSANAVYDVPEGRPVWKVLPLRVALTVVLLVLAVVSALIVVFTGSLARQAGTALGVGDTALTVWSIAKWPVLVLLVTFMIAILYWAAPNARVKGFKWISPGSLVALLIWLLASAGFAFYVANFGSYNKTYGTLAGVIIFLVWLWVTNLAILLGLEFDAELARQRVIDGGHPPEEEPYVEPRDTRAWNEADRRRAASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK42</accession>
    <name>Q9RK42_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0337</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2006-03" db="PDB data bank">
            <title>Crystal structure of the putative transcriptional regulator SCO0337 from Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Hayashi T."/>
                <person name="Tanaka Y."/>
                <person name="Sakai N."/>
                <person name="Yao M."/>
                <person name="Tamura T."/>
                <person name="Tanaka I."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-187</scope>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624661.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027030.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="PDB" id="2DG7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=1-187"/>
    </dbReference>
    <dbReference type="PDBsum" id="2DG7"/>
    <dbReference type="SMR" id="Q9RK42"/>
    <dbReference type="STRING" id="100226.SCO0337"/>
    <dbReference type="GeneID" id="1095760"/>
    <dbReference type="KEGG" id="sco:SCO0337"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.311"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RK42"/>
    <dbReference type="OMA" id="MARWQPG"/>
    <dbReference type="PhylomeDB" id="Q9RK42"/>
    <dbReference type="EvolutionaryTrace" id="Q9RK42"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB56142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2DG7"/>
        </source>
    </evidence>
    <sequence length="188" mass="20354" checksum="2B586E7924DBAB18" modified="2000-05-01" version="1">MARWDPGAEQRLKRAALELYSEHGYDNVTVTDIAERAGLTRRSYFRYFPDKREVLFGGSELLPPAVARAVLAADPGAAPLTAVLDAMSQVGAQLVAQVEGAAQRRAVIDASPELQERERTKSAAISRAVQDALVRRQVDADTAELVAQLATVAFGSAFRRWIDAEGHADFGSCLDTVTDRLRAVLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK43</accession>
    <name>Q9RK43_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0336</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624660.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027029.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0336"/>
    <dbReference type="GeneID" id="1095759"/>
    <dbReference type="KEGG" id="sco:SCO0336"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.310"/>
    <dbReference type="eggNOG" id="COG3268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885417_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RK43"/>
    <dbReference type="OMA" id="TDCLAAH"/>
    <dbReference type="PhylomeDB" id="Q9RK43"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="369" mass="37528" checksum="BEBEBFFEEF117364" modified="2000-05-01" version="1">MTETSGTTSGNRTNDEVWIVGATGRVGRGVTGRLAARGLTVVPVGRSRERMAAAGAAAGLPADAKTVVADSAERIAEEVLRQRPRAVVNTMGAYATTAPVIARACMSVGGHYVDQANDVVAVEGLLALHEDATRAGSTLVTGAGFGVLATEAVVAKLCEERPAPHRVRIDSVASVAVEAGAVGAALATSIVDTLTAGGRRYADGRLVASRLGADPQRLTFPDGTSARSAGVASGELVAARAASGAPFVTATSSLAPSTPLLRAVVPALGRLLSVPALRRLAVARLGRVTVKAAPRPREHSWGHAVVEWADGTRREGWLRADEGMDFTADVTATVTELLARGAGRPGAWTPAGALGPDVATSAGGTFVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKX8</accession>
    <name>Q9RKX8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1419</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625701.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977406.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKX8"/>
    <dbReference type="STRING" id="100226.SCO1419"/>
    <dbReference type="GeneID" id="1096845"/>
    <dbReference type="KEGG" id="sco:SCO1419"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1429"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_6_11"/>
    <dbReference type="InParanoid" id="Q9RKX8"/>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="PhylomeDB" id="Q9RKX8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="15"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="255" mass="28244" checksum="6624B01A56E2447F" modified="2000-05-01" version="1">MTTPIRHPYLDHPGPIAFAHRGGAADGLENTLRQFRRAVGAGYRYIETDVHATRDGKLVAFHDGTLDRVTDGAGRIADLPWENVRHARVAGEEPVPLFEELLETFPAVRWNVDVKAEPALEPLLELIGRHNAWDRICVGSFSEARVVRAQRLAGPRLATSCGTRGVLGLRLRSWGVPVAPRRSAVAAQVPETQSGVPVVDHRFLRAAHARGLQVHVWTVNDADRMHRLLDLGVDGIMTDHIDTLRKVMEDRGVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKZ2</accession>
    <name>Q9RKZ2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative CbxX/CfqX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1434</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625716.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027787.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1434"/>
    <dbReference type="GeneID" id="1096860"/>
    <dbReference type="KEGG" id="sco:SCO1434"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1444"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008749_5_1_11"/>
    <dbReference type="InParanoid" id="Q9RKZ2"/>
    <dbReference type="OMA" id="TLNSWYW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="374"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="618" mass="67299" checksum="5D9078BF051C1EC5" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL03</accession>
    <name>Q9RL03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0315</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624642.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027010.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0315"/>
    <dbReference type="GeneID" id="1095739"/>
    <dbReference type="KEGG" id="sco:SCO0315"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.290"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_3_1_11"/>
    <dbReference type="InParanoid" id="Q9RL03"/>
    <dbReference type="OMA" id="NADNPQE"/>
    <dbReference type="PhylomeDB" id="Q9RL03"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="44"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="291"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB55672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="452" mass="47260" checksum="781DC903629BDC47" modified="2000-05-01" version="1">MTSGSLHQRGTAREAALARAVEDGLLGPRTPLVGLLDVDGVLAAVDALNEAFEGPAPVQHTFAAKACGLVPVLRLLAEAGMGCEVASPGELEQALAAGFTYDRLVFDSPAKTVEELEFALAHGIAINLDNFQEMARVDGLLAGREAAGPIGLRVNPQVGAGAIGAMSTATATSKFGVALRDEGAVDAVIEAFARRPWLNRLHAHVGSQGCPLPLIAQGVRTAYELAERINRELGRAQITGLDIGGGLPVNFDGEDDRPTYADHVAELRSAAPGLFDGRYALITEFGRSLLAKSGTIASVVEYTKSAGGRRIAVTHAGAQVATRTVFMPDAWPLRVGVFDAAGRPKQGPAEVVDIAGPCCFAGDLTATGRELPAVEPGDVVALYDTGAYYFSSHFSYNSLPRPAVYGYRTDSRGQIAFALVREAQSVRAVVEESGLAQADALVALGTDQSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1V2</accession>
    <name>Q9S1V2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0040</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37104">
        <property type="entry name" value="T37104"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624398.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026800.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0040"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095473"/>
    <dbReference type="KEGG" id="sco:SCO0040"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.32"/>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_7_1_11"/>
    <dbReference type="InParanoid" id="Q9S1V2"/>
    <dbReference type="OMA" id="PFGRDQF"/>
    <dbReference type="PhylomeDB" id="Q9S1V2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="407" mass="43499" checksum="A61E94CF6088B4A0" modified="2000-05-01" version="1">MSTLAFLNIGMHGHINPTLPVAAELVRRGHTVTYHTFPAFREEIAATGANVRLYPGGDQPLPDPPAPITLMEALARTSLDLLPAVLADLRDDRPDLIVHDSACPWGALAARVLGLPAVSSFTTFAYNRHVPSPTRASRELLAGAAARPRNLAGYVGARLALRRRFAATGVPLVDLADIRQPLNLVYTSRAFQPAVEEFDRSYRFVGPSIGARPDDPSFPVNRLRDPVLYASLGTVFNADPLLLRTFATALSPLAGTVVVSTGQTDPAALGELPGNVLARRSVPQLEVLDRAALFITHGGMNSVNEALFAGVPLLLVPQGADQPMVARRVVELGAGLSIRTENITEDSVRAVARRLLEDSRYRAATSGLRATQHEAGGYRRAADELEGYLRPTGAVPVHPAPVDPQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S227</accession>
    <name>Q9S227_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO1773</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36876">
        <property type="entry name" value="T36876"/>
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    <dbReference type="RefSeq" id="NP_626044.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1773"/>
    <dbReference type="GeneID" id="1097204"/>
    <dbReference type="KEGG" id="sco:SCO1773"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1790"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S227"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="PhylomeDB" id="Q9S227"/>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:alanine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ala_DH"/>
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        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAB52837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="371" mass="39571" checksum="D8533893A0CFE8FD" modified="2000-05-01" version="1">MKVGIPREVKNNEFRVAITPAGVHELVRHGHQVVVERNAGVGSSIPDEEYVTAGARILDTADEVWATADLLLKVKEPIAEEYHRLRKDQTLFTYLHLAASKECTDALIESRTTAIAYETVELPSRALPLLAPMSEVAGRLAPQVGAYHLMAANGGRGVLPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIFGTKIQTVVSNAFELEKACLEADLVIGAVLIPGAKAPKLVTNELVSRMKPGSVLVDIAIDQGGCFEDSHPTTHAEPTFPVHNSVFYCVANMPGAVPNTSTYALTNATLPYIVELADRGWAEALRRDPALAKGLNTHDGKVVYREVAEAHGLEHVELASLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S286</accession>
    <name>Q9S286_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1744</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36766"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626017.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027952.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S286"/>
    <dbReference type="STRING" id="100226.SCO1744"/>
    <dbReference type="GeneID" id="1097175"/>
    <dbReference type="KEGG" id="sco:SCO1744"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1762"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9S286"/>
    <dbReference type="OMA" id="YALRERT"/>
    <dbReference type="PhylomeDB" id="Q9S286"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="292"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB50959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="388" mass="40765" checksum="52333785585166F2" modified="2000-05-01" version="1">MNDLFGRARAAYDLLVARRSALFDLVLAVITTGVEIGQLFDGGTPVVVIPAAVIPVGVIPVVVTVLTGSALLLRRRAPLTVLVTACAGAAVLVPLGYSPGGAPVVVALASLADLRDRRVSVAALVPTALFLLLASISSLPVPVGAWALGSYLQTRRRYTRALEDRAATLERERAQLDQLAAQRERTAIARELHDIVAHSVTVMLIGVRGARDVLPTDPGVAAETLEPVEVNAEQSLAELRRILGLLRTPDNGAQWRPQPSLGQLPELVSGYRTAGMPVQLEFTGEARPLAGGLELSAYRIVEEALTNVLKHTDPTRVTVTLHYGRTWLDVTVEDDGGGGGPAPSGAGHGILGMRERAAVTGGSLDARRTADGFVVTARLPVEDAGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S290</accession>
    <name>Q9S290_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36762">
        <property type="entry name" value="T36762"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626013.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977086.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1740"/>
    <dbReference type="GeneID" id="1097171"/>
    <dbReference type="KEGG" id="sco:SCO1740"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1758"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045983_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S290"/>
    <dbReference type="OMA" id="GWCVGGY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="354" mass="35981" checksum="57B93FA9CD2BF5D0" modified="2000-05-01" version="1">MSHTPGPGTRSGSFLGEVRDAVTPRATLLVLGVIALQLLFIASYVGALHDPRPKDVPFGVVAPGAAAGQTVDRLEGLPGSPLDPRTVADEAAARRQIMNREIDGALVLDPGGRQDTLLVASGGGTVLATTLEGIVGKAEQTERRTVRVVDVAPASRHDFDGLSSFYLIVGWCVGGYLCASILAISTGARPANPRRAAIRLIVMALVAIVGGLGGAVIIGPILGALPGGVLDLWGLGALITFAVGAATLALQGVFGIVGIGLAILLVVIAGNPSAGGAFPLPLLPPFWKAIGPALPPGAGTWAARSIAYFKGNDVTASLLVLWAWAVAGTVITMLAAVLPRRGRQETELPPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2A6</accession>
    <name>Q9S2A6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO1724</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36746">
        <property type="entry name" value="T36746"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625997.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027941.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1724"/>
    <dbReference type="GeneID" id="1097155"/>
    <dbReference type="KEGG" id="sco:SCO1724"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1741"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_11"/>
    <dbReference type="InParanoid" id="Q9S2A6"/>
    <dbReference type="OMA" id="RMYARLE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB50939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="550" mass="55562" checksum="060D9C75E4418B16" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2P7</accession>
    <name>Q9S2P7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2189</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35305">
        <property type="entry name" value="T35305"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626442.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976627.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2189"/>
    <dbReference type="GeneID" id="1097622"/>
    <dbReference type="KEGG" id="sco:SCO2189"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2226"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_19_2_11"/>
    <dbReference type="InParanoid" id="Q9S2P7"/>
    <dbReference type="OMA" id="HVRQIQG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="169" mass="18506" checksum="D1AB1E902E164402" modified="2000-05-01" version="1">MIAMPAPHIRRARSEDEHPLRRIDLETWSYLHAVSPPPGPDDPFFRDTCGPDAHLVAELDGAVVGYVRLGFPTPLASNTHVRQIRGLAVAGAARGHGVGRALVRAAVEEARHEGFRRITLRVLGHNTAARGLYESEGFVVEGVQPEEFHLDGRYVDDVLMGQMLTALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2S7</accession>
    <name>Q9S2S7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2062</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35091">
        <property type="entry name" value="T35091"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626322.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028124.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2062"/>
    <dbReference type="GeneID" id="1097496"/>
    <dbReference type="KEGG" id="sco:SCO2062"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2094"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697882_0_0_11"/>
    <dbReference type="OMA" id="RWSSDKG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="403" mass="43962" checksum="FE13AF30507EF383" modified="2000-05-01" version="1">MDRCIVLVDAGYLLGAAASLLAGEPSRSRITVDHAALIQGLRDRAESDTQQPLLRIYWFDGAPDRVPQPEHRRLRVMPRVTVRLGALTRSDGRWAQKGVDAAMHAELTELARNRACSDVVLVTGDGDLLPGMMAAKEHGVAVHLWAVQAADGDYNQSEDLVAEADERRVLDRTWITKAVRAKELGGICAPPPVPRPEIAAILSAPLPESALSAAQRPAETPEHPTTAAAGPTGTEERVPPAKGVPTPKDLAALRAPGAHPAPQPANATLRWSSDKGWVDRPAAEPSEAATLPTLAQLTTAEQRWADREEDITTVGGDPYEVGQVFARRWLERLGDHGHLQKLSGMYPRIPHRVDGELLRYAARFGLLAHKDDQIDEHDRYAIRAGFWREIDVRTATERTPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7W7</accession>
    <name>Q9X7W7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6772</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35412">
        <property type="entry name" value="T35412"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972225.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6772"/>
    <dbReference type="GeneID" id="1102211"/>
    <dbReference type="KEGG" id="sco:SCO6772"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6881"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X7W7"/>
    <dbReference type="OMA" id="HTIFDFR"/>
    <dbReference type="PhylomeDB" id="Q9X7W7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="31383" checksum="7CEC2BA464B7701E" modified="1999-11-01" version="1">MPYRRVEPAGEQRRRGGVGGAPVTQQVPSTEPELTGVRNFRDVGGLPTVDGRRVRQGVLFRSGHLAHATGEDAAFLASLGLHTIFDFRNAADQKLEGPDVDLPGVRNVNLPLSDPADGAEFWKMVRDGDLDQLREILADGKAADRMIGSYRAIVTERTAEHSRILHALAEDSVPALMHCAAGKDRAGLSIAVTLLALGVEREAVVEDYLKSNAAHRRYKVRRSGSAASAYSPEVMELLSPLFDARAEYLAAAFETVEETWGGVDAYLEQGLRLTPATRERLRERMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X847</accession>
    <name>Q9X847_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3386</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36074">
        <property type="entry name" value="T36074"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627593.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975447.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3386"/>
    <dbReference type="GeneID" id="1098823"/>
    <dbReference type="KEGG" id="sco:SCO3386"/>
    <dbReference type="HOGENOM" id="CLU_2439384_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB40926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="90" mass="8445" checksum="F8813612659A0D1B" modified="1999-11-01" version="1">MPLADDPPVVGAGRGRPGFTELPGPVGVEEVLLRDAHGGSPSQGDVAVGTGSAAAPVTPDCAGPRPAVASIDGGGQSAAALSVAACTMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X851</accession>
    <name>Q9X851_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3390</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36078">
        <property type="entry name" value="T36078"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627597.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975443.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3390"/>
    <dbReference type="GeneID" id="1098827"/>
    <dbReference type="KEGG" id="sco:SCO3390"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3453"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="Q9X851"/>
    <dbReference type="OMA" id="WVLGDSI"/>
    <dbReference type="PhylomeDB" id="Q9X851"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="401" mass="43101" checksum="7BBF18CBF6C0B018" modified="1999-11-01" version="1">MQRLYDFLRRHPTGVDSFWAFVVLGVSLVSAATPGTRADGTDNVALIVPFVVLLSVVIALRQRAPERMLLLAVVLGLGQLAFDVSTMPADFAFLVIIYTVAATGARWASRTALATGLCAAPLAQLRWSDSELGMGTTIAVTVFQAVPFALAWVLGDSIRTRRAYFAQLEERATRLEKEREAQAKVAVAAERARIARELHDVVAHNVSVMVVQADGAAYVLDAAPDQAKKALETISSTGRQALAEMRRLLGVLRTGEHKEAGEYVPQPDVEQIEDLVEQCRTSGLPVDFKIEGTPRQLPSGVELTAYRIVQEALTNTRKHGGENAGASVRLVYFDDGLGLLIEDDGKGAPHELYEEGGFDGQGHGLIGMRERIGMVGGTLDAGPRPGGGFRISALLPLKPAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X889</accession>
    <name>Y3297_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0060 membrane protein SCO3297</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3297</name>
        <name type="ORF">SCE15.14</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0060 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB41283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36117">
        <property type="entry name" value="T36117"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627508.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028891.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X889"/>
    <dbReference type="STRING" id="100226.SCO3297"/>
    <dbReference type="GeneID" id="1098731"/>
    <dbReference type="KEGG" id="sco:SCO3297"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3358"/>
    <dbReference type="eggNOG" id="COG1742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117653_0_1_11"/>
    <dbReference type="InParanoid" id="Q9X889"/>
    <dbReference type="OMA" id="WLWAVEG"/>
    <dbReference type="PhylomeDB" id="Q9X889"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000162353" description="UPF0060 membrane protein SCO3297">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <sequence length="112" mass="11924" checksum="6444404F1212595F" modified="1999-11-01" version="1">MLVLRSAALFVVAALFEIGGAWLVWQGVREQRGWLWAAGGVLALGAYGFVATFQPDAHFGRILAAYGGIFVTGSILWGVVADGYRPDRWDIAGALVCLAGMALIMWAPRNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8X6</accession>
    <name>Q9X8X6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3694</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB44397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36629">
        <property type="entry name" value="T36629"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627886.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975243.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3694"/>
    <dbReference type="GeneID" id="1099130"/>
    <dbReference type="KEGG" id="sco:SCO3694"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3753"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_4_0_11"/>
    <dbReference type="InParanoid" id="Q9X8X6"/>
    <dbReference type="OMA" id="IEDNHAY"/>
    <dbReference type="PhylomeDB" id="Q9X8X6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB44397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="124" mass="13783" checksum="A75D8FFE0D338E5A" modified="1999-11-01" version="1">MRIGELSARTGASRRSLRYYEEQGLLVSSRSPSGQRHYEEEHVQRVRLVQAFLAAGVSSGTLVEMVPCMSEPSEGRARQALEIMGRERARLSEDIDGLVAARDALDHLIEDNHAYLTRSADGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAJ7</accession>
    <name>Q9XAJ7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zinc_ribbon_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3605</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35373">
        <property type="entry name" value="T35373"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627800.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029116.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3605"/>
    <dbReference type="GeneID" id="1099041"/>
    <dbReference type="KEGG" id="sco:SCO3605"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3663"/>
    <dbReference type="eggNOG" id="ENOG503370T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159385_0_0_11"/>
    <dbReference type="InParanoid" id="Q9XAJ7"/>
    <dbReference type="OMA" id="TKGYLYQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031493">
        <property type="entry name" value="Zinc_ribbon_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17032">
        <property type="entry name" value="zinc_ribbon_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_15" evidence="2">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="98" mass="10985" checksum="DDBCBDDA1F9E4B25" modified="1999-11-01" version="1">MIIFGTKGYLYQLAILTLVCGRCGNPAAHTLRKRVTKFTLFFVPLFPFSTKYATQCTFCGAEQQVTREQAEQLQAQEAGGQAYGPSGQQPYQQPYQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAP5</accession>
    <name>Q9XAP5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4553</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34633">
        <property type="entry name" value="T34633"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628715.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974392.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4553"/>
    <dbReference type="GeneID" id="1099993"/>
    <dbReference type="KEGG" id="sco:SCO4553"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4625"/>
    <dbReference type="eggNOG" id="ENOG50329QB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159378_0_0_11"/>
    <dbReference type="OMA" id="AFMGWGT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB44540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="139" mass="13362" checksum="20B9225641357CBC" modified="1999-11-01" version="1">MRSEPVTASRAATRGRRRKRGIAPAEGPVFVDSTGRRARLLRRLGLLVGAVCVGYTAVLGLAFMGVGISVNPSSLLPFGVGGGGGPEGGPGPGGGTRPQGGVAPTGVPPSPAPSASPSAVPGTAPATASSAAPSTAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAS4</accession>
    <name>Q9XAS4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4582</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34604">
        <property type="entry name" value="T34604"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628744.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974365.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4582"/>
    <dbReference type="GeneID" id="1100022"/>
    <dbReference type="KEGG" id="sco:SCO4582"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4654"/>
    <dbReference type="eggNOG" id="COG3953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083020_2_0_11"/>
    <dbReference type="InParanoid" id="Q9XAS4"/>
    <dbReference type="OMA" id="MSANGQN"/>
    <dbReference type="PhylomeDB" id="Q9XAS4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177053" description="SLT domain-containing protein" evidence="1">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="17165" checksum="4DC1E4B5AAE22098" modified="1999-11-01" version="1">MSANGQNRHARTSRLARKLAVAGTGAAVLALPLIGATTASAATPAAATTATTAATAYPDNLDGWIRESLDIMAQHGIPGTYEGIHRNIMRESSGNPLAINNWDINAINGTPSKGLLQVIDPTFQAYHVEGTSWDPYDPVANITAACNYAADRYGSMDNVFSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z509</accession>
    <name>Q9Z509_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator (LacI family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1956</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36029">
        <property type="entry name" value="T36029"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626220.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028064.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1956"/>
    <dbReference type="GeneID" id="1097390"/>
    <dbReference type="KEGG" id="sco:SCO1956"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1982"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_11"/>
    <dbReference type="InParanoid" id="Q9Z509"/>
    <dbReference type="OMA" id="NPYFTEI"/>
    <dbReference type="PhylomeDB" id="Q9Z509"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="368" mass="39168" checksum="EF8C3E6E6F08E774" modified="1999-05-01" version="1">MATMADVARSAGVSVATVSHVLNDTRPVLPHTRRAVLDAVEELGYTTNTLARSLVTSRTRSIGLAVSAISNPYFTEILQGVEASALEHGYGLLIADPHEDPAHEREVVRLLHERRVDGMIVAPSAEPRELVSYLTRHRVPAVFLDRIVDVPEGEDAPRFDQVGAEGAEPTTGLVDHLAGLGHRRIGLVAGRPGLSTTRERITGYRHGLAAAGLPFDERLLVHGDSEAAAGERATADLLSLAVPPTALVTANNAMTIGALRAVRSRGLSVPGDLALCCFDDFAWADLFSPRLTAVAQPSRDIGAQAVRLLLDRLAEPDRPARTLRLPCTFVHRGSCGCVEQPGPLSEKSGHVAGPSGKADAKAHERTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z531</accession>
    <name>Q9Z531_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative peptide transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5712</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAB37471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35983">
        <property type="entry name" value="T35983"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629839.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030405.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5712"/>
    <dbReference type="GeneID" id="1101151"/>
    <dbReference type="KEGG" id="sco:SCO5712"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5802"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="Q9Z531"/>
    <dbReference type="OMA" id="PRHTVYD"/>
    <dbReference type="PhylomeDB" id="Q9Z531"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB37471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="359" mass="37859" checksum="07BCB459A41504E1" modified="1999-05-01" version="1">MSSTLPDGAPDEAPGAVPDTAPDTAPDSAPPLLSVRGLHVTFPGRRGAAAARAVDGVDLDIRRGEIVALVGESGCGKTTLARSLLGLVRPTGGRVTFDGAPLGYSARALKAYRRRAQLVLQDPSGSLNPRHTVYDIVAEGLRIHGHAGDERTAVAEALSRAGLRPPERFFLRYPHELSGGQRQRVVIAGALVLQPELLVADEPVASLDASVRGEILALLLRLRTELGLSALVVTHDLGLAWNIADRVAVMYLGRIVETGAVEQVLTAPRHPYTQALLSVLPEAPGAPVVLTGEPPDPSYIPGGCRFHVRCPVLASGEAVRAGVADACRNEELEILRGGDESQVACHWARAERPVAERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="145" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5A9</accession>
    <name>Q9Z5A9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6193</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34847">
        <property type="entry name" value="T34847"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630296.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030729.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6193"/>
    <dbReference type="GeneID" id="1101634"/>
    <dbReference type="KEGG" id="sco:SCO6193"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6306"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_0_11"/>
    <dbReference type="InParanoid" id="Q9Z5A9"/>
    <dbReference type="OMA" id="ETLMGHP"/>
    <dbReference type="PhylomeDB" id="Q9Z5A9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="876"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB36601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="943" mass="99458" checksum="10F2DA6B0C965FB1" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBJ1</accession>
    <name>Q9ZBJ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6483</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35970">
        <property type="entry name" value="T35970"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630566.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <source>
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        </source>
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    <sequence length="815" mass="84283" checksum="9AD3C72DF086DB96" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBS9</accession>
    <name>Q9ZBS9_STRCO</name>
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        <submittedName>
            <fullName evidence="6">Putative gntR family transcriptional regulator</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="ordered locus">SCO6159</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="273" mass="28699" checksum="B82D49CD374B6F00" modified="1999-05-01" version="1">MKHSAQGAARTGVGTGTGAAAEAVRIPVQPGAADRARGRAPGGAEPDGPARGEHTHGEPPVPRPRALVQRSSVRGQILDALRSALVTGELRPGEVYSAPVLGERFGVSATPVREAMQQLALEGAVEVVPNRGFRVLERGDRELAELAEVRALIEVPVWLRLARTVPAEHWAELRPLAEGTVRAASSGCPATYAEADRAFHRAALALAGNEQLVRIAGDVHRRAQWPPAGSPSVRGRADLVADAHQHTALLDALIAGDLDVVRALVGDHFTVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBT0</accession>
    <name>Q9ZBT0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FhuF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6158</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34671">
        <property type="entry name" value="T34671"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630263.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030696.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6158"/>
    <dbReference type="GeneID" id="1101599"/>
    <dbReference type="KEGG" id="sco:SCO6158"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6266"/>
    <dbReference type="eggNOG" id="COG4114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086030_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBT0"/>
    <dbReference type="OMA" id="RYAWPAC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA22392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="30237" checksum="9434AB61E21FB65C" modified="1999-05-01" version="1">MPVARTALTDAYTRLSEVLPGLGVTELAAADEVPSGGGWVTAASLAAGGTELAAFLAWDEAQVLRDYGQRARPDVIASFGLHRYAWPACLLITVPWFLHRRVPRHPAAHVSYDRTAAGLPLGRMAVRAASFACLPGDPAAALPGARVVADEEALRAEVRAAVAEHLEPVLAGFGPRMRRRGRALWGMATDEVVEGLWYVAHLLGEQERARHELELLLPGATRPYVGKAAFRELKGPDGAPLHTRDRASCCMFYTLRPEDTCATCPRTCDADRVDKLLAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBT3</accession>
    <name>Q9ZBT3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6155</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34668">
        <property type="entry name" value="T34668"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630260.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030693.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6155"/>
    <dbReference type="GeneID" id="1101596"/>
    <dbReference type="KEGG" id="sco:SCO6155"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6263"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBT3"/>
    <dbReference type="OMA" id="YEATHEC"/>
    <dbReference type="PhylomeDB" id="Q9ZBT3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="192"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="383"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA22389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="580" mass="62504" checksum="E4708ED5AA1C8588" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O54187</accession>
    <name>Y5958_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Putative ABC transporter ATP-binding protein SCO5958</fullName>
            <ecNumber>7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5958</name>
        <name type="ORF">SC7H1.28c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35723">
        <property type="entry name" value="T35723"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630075.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030564.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54187"/>
    <dbReference type="SMR" id="O54187"/>
    <dbReference type="STRING" id="100226.SCO5958"/>
    <dbReference type="GeneID" id="1101400"/>
    <dbReference type="KEGG" id="sco:SCO5958"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6055"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="O54187"/>
    <dbReference type="OMA" id="FVFQRPA"/>
    <dbReference type="PhylomeDB" id="O54187"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092094" description="Putative ABC transporter ATP-binding protein SCO5958">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="284" mass="29603" checksum="787541FCAD7B6009" modified="1998-06-01" version="1">MSEPAQPSEPAPALVALRGAAFAYEEGPDVLTGLDFAVREGRALALLGRNGSGKTTLMRLLSGGLKPHTGTLTLGGEPVAYDRKGLTRLRTTVQLVVQDPDDQLFAASVGQDVSFGPLNLGLSDAEVRSRVGEALAALDISGLAERPTHLLSYGQRKRTAIAGAVAMRPRVLILDEPTAGLDPDGQERLLATLDGLRAGGTTVVMATHDVDLALRWSDDAALLTPEGVRTGPTAATLARTDLLRRAGLRLPWGVAATGLLRARGLLADSATGPRTAEELAALAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O69830</accession>
    <name>CHDC_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Coproheme decarboxylase</fullName>
            <ecNumber evidence="1">1.3.98.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 3">Coproheme III oxidative decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1 3">Hydrogen peroxide-dependent heme synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">chdC</name>
        <name evidence="4" type="ordered locus">SCO6042</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="25978" last="25986">
            <title>Discovery and characterization of HemQ: an essential heme biosynthetic pathway component.</title>
            <authorList>
                <person name="Dailey T.A."/>
                <person name="Boynton T.O."/>
                <person name="Albetel A.N."/>
                <person name="Gerdes S."/>
                <person name="Johnson M.K."/>
                <person name="Dailey H.A."/>
            </authorList>
            <dbReference type="PubMed" id="20543190"/>
            <dbReference type="DOI" id="10.1074/jbc.m110.142604"/>
        </citation>
        <scope>PATHWAY</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme b</text>
            <dbReference type="Rhea" id="RHEA:56516"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="EC" id="1.3.98.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:56517"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O + harderoheme III</text>
            <dbReference type="Rhea" id="RHEA:57940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:142463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:57941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b</text>
            <dbReference type="Rhea" id="RHEA:57944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:142463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:57945"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </cofactor>
        <text evidence="1">Fe-coproporphyrin III acts as both substrate and redox cofactor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ChdC family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA18976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34680">
        <property type="entry name" value="T34680"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630152.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972879.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O69830"/>
    <dbReference type="SMR" id="O69830"/>
    <dbReference type="STRING" id="100226.SCO6042"/>
    <dbReference type="GeneID" id="1101483"/>
    <dbReference type="KEGG" id="sco:SCO6042"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6143"/>
    <dbReference type="eggNOG" id="COG3253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076582_1_0_11"/>
    <dbReference type="InParanoid" id="O69830"/>
    <dbReference type="OMA" id="RYTMWSV"/>
    <dbReference type="PhylomeDB" id="O69830"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02244">
        <property type="entry name" value="Coproheme_decarbox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000450277" description="Coproheme decarboxylase">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="20543190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAA18976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="28132" checksum="6180412A99FD8E04" modified="1998-08-01" version="1">MSDDASTPAAERIPNKGKLAKDLNEVIRYTLWSVFKLKDTLPEDRAGYADEVQELFDQLAAKDVTIRGTYDLSGLRADADLMIWWHAETADQLQEAYNLFRRTKLGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYISVYPFVRSYDWYLLPDEDRRRMLADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELHRIVDLMRHLRGSEARRHVREEIPFYTGRRKDIGELVAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-06-02" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O69885</accession>
    <name>O69885_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5597</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34782">
        <property type="entry name" value="T34782"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629731.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030326.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5597"/>
    <dbReference type="GeneID" id="1101038"/>
    <dbReference type="KEGG" id="sco:SCO5597"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_0_3_11"/>
    <dbReference type="InParanoid" id="O69885"/>
    <dbReference type="OMA" id="IAWPFGH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="56"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA19389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="446" mass="49018" checksum="7DEBD35C107D8590" modified="1998-08-01" version="1">MGSRGKPRGAPSSPAENLLPTGSRRTAAPSGGRSRAERRKLQRKVKRRRRRGAVKEIPLLVGVAVLIALVLKTFLVQAFVIPSGSMEQTIRIGDRVLVDKLTPWFGSEPQRGDVVVFRDPGGWLQGEQTTKKDDPVVVKQVKEGLAFIGLLPSDDEKDLIKRVVGVGGDHVKCCDKQGRVTVNGVPLTEDYLYPGDRPSRTPFDVTVPEGRLWVMGDHRSNSADSRAHQETDFGTVSQDEVVGRAMVIAWPFGHWTTLDEPKTYASVSDAASGSTAAPELSHRVAPYDPNAMMELPTPAELPLVMGVVGLRRIRGRRRQRVRSWRGGCGGWRTVRSRRRGEPRTPRGEVRSGRGRRPRLRTRLRNRGRQGDERTARAGRTQRRDGGRGSRRDATRDPARGQEAALLLEGAADPGRHRAGARPADQDVPGAGVLDPVLLDGEHPSDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O86509</accession>
    <name>AGUA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative agmatine deiminase</fullName>
            <ecNumber evidence="1">3.5.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Agmatine iminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aguA</name>
        <name type="ordered locus">SCO5527</name>
        <name type="ORF">SC1C2.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + H2O = N-carbamoylputrescine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:58318"/>
            <dbReference type="EC" id="3.5.3.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the agmatine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.12" evidence="1"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29057">
        <property type="entry name" value="T29057"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629661.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973469.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86509"/>
    <dbReference type="SMR" id="O86509"/>
    <dbReference type="STRING" id="100226.SCO5527"/>
    <dbReference type="GeneID" id="1100967"/>
    <dbReference type="KEGG" id="sco:SCO5527"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5614"/>
    <dbReference type="eggNOG" id="COG2957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037682_0_0_11"/>
    <dbReference type="InParanoid" id="O86509"/>
    <dbReference type="OMA" id="WCRDHGP"/>
    <dbReference type="PhylomeDB" id="O86509"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01841">
        <property type="entry name" value="Agmatine_deimin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017754">
        <property type="entry name" value="Agmatine_deiminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000194343" description="Putative agmatine deiminase">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01841"/>
        </source>
    </evidence>
    <sequence length="339" mass="37142" checksum="0733B636C45FB63C" modified="1998-11-01" version="1">MTFRMPPEWAPHERTWMAWPGPNATFTDAEELAGARAAWASVARAVRRFEPVTMVHGPGQAATARELLGPDVDLVERELDDAWMRDIGPTFVTDGRGGLAAVDWVFNGWGAQDWARWEHDAEIARHVADLAAAPVLSSPLVNEGGAIHVDGEGTVLLTDTVQLGSGRNPGWSREEVEAEIHAKLGTTTAIWLPHGLAGDYGRYGTQGHVDIVAAFARPGTVVVHSQRDPRHPDHERSQLYLEILRGRTDARGRRLEVVEVPAPTVLKDEEGEWADYSYINHYVCNGGVVLCAFGDPNDELAAGIFRRLFPERTVTLVDARTIFAGGGGIHCITQQQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O86554</accession>
    <name>O86554_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6620</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29126">
        <property type="entry name" value="T29126"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630697.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972358.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6620"/>
    <dbReference type="GeneID" id="1102059"/>
    <dbReference type="KEGG" id="sco:SCO6620"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6727"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_8_11"/>
    <dbReference type="InParanoid" id="O86554"/>
    <dbReference type="OMA" id="CCEPPNV"/>
    <dbReference type="PhylomeDB" id="O86554"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13463">
        <property type="entry name" value="HTH_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="143" mass="15406" checksum="95FC11E5CDE55ED2" modified="1998-11-01" version="1">MTRSTLEAAVAANHELFMQTGDRIEAVLTEHGLTPATAQALWAIDPDQAPPSMKTLAGRLYCNAPNLSFVMNQLTDRGLVERSADPADRRSRVVALTDDGRRVRAAVIEATLALTPFARLGDEELRQLVDLLGKALEPAAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>O86575</accession>
    <name>O86575_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO5480</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAA20183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34760">
        <property type="entry name" value="T34760"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629616.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030272.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5480"/>
    <dbReference type="TCDB" id="3.A.1.5.34">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1100920"/>
    <dbReference type="KEGG" id="sco:SCO5480"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5564"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_11"/>
    <dbReference type="InParanoid" id="O86575"/>
    <dbReference type="OMA" id="TIHVLGQ"/>
    <dbReference type="PhylomeDB" id="O86575"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAA20183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="496" mass="52063" checksum="A8CF5C3560A50DB4" modified="1998-11-01" version="1">MSDEAKDEAVAIPAQSDGTESTSAGAATLTKGAAPGETLLKVTGLQKHFPIRKGLLQRQVGAVRAVDGIDFEVRSGETLGVVGESGCGKSTMGRLITRLLEPTAGKVEFQGKDITHLGVGGMRPLRRDVQMIFQDPYSSLNPRHTIGTIVSAPFKLQGVQPEGGVKKEVQRLLSVVGLNPEHYNRYPHEFSGGQRQRIGIARALALNPRLVVADEPVSALDVSIQAQVVNLLDDLQQELGLTYVIIAHDLSVVRHVSDRIAVMYLGKIMELADRDLLYKTPMHPYTKALMSAVPIPDPARRGAKSERILLKGDVPSPIAPPSGCRFHTRCWKATQVCTTTEPPLKELRPGQQVACHHPENFEDQAPQDVVLLTAAKEAAELVSEDALAESAATSAAVAAEVEASEAEASEETASSDAASDGAASEEAASSDAASDDSASDGAAPKEAASSDAASDDAGSSDSVSDDAAPDDSASDGDEPAAESAGSTDEEPPAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O86587</accession>
    <name>O86587_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37220">
        <property type="entry name" value="T37220"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630323.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972705.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6222"/>
    <dbReference type="GeneID" id="1101663"/>
    <dbReference type="KEGG" id="sco:SCO6222"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6336"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_11"/>
    <dbReference type="InParanoid" id="O86587"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="PhylomeDB" id="O86587"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="402" mass="44449" checksum="56647BB6DB88AAA4" modified="1998-11-01" version="1">MEFRQSNKLSEVCYEIRGPVIEHANALEEAGHSVLRLNTGNPALFGFEAPEEIVQDMIRMLPRAHGYTDSRGILSARRAVAQRYQALGLEVDVDDVFLGNGVSELISMAVQALLEDGDEVLIPAPDFPLWTAVTTLAGGKAVHYLCDEQAEWYPDLADMEAKITDRTKAVVIINPNNPTGAVYPKEIVEGILDLARRHGLMVLADEIYDQILYDDAVHHSAASLAPDLVVLTFCGLSKTYRVAGFRSGWLVVTGPKQHARDYLEGLTMLASMRLCANAPAQYAIQAALGGRQSIRELTAPGGRLHEQRDVAWEKLNEIPGISCVKPKGALYAFPRIDPAVHKIHDDERFVLDLLLREKIQVVQGTGFNWPSPDHFRILTLPHAEDLEAAIGRIGRFLSGYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O86614</accession>
    <name>O86614_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6345</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29431">
        <property type="entry name" value="T29431"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630437.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030844.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6345"/>
    <dbReference type="CAZy" id="AA10">
        <property type="family name" value="Auxiliary Activities 10"/>
    </dbReference>
    <dbReference type="CAZy" id="CBM5">
        <property type="family name" value="Carbohydrate-Binding Module Family 5"/>
    </dbReference>
    <dbReference type="GeneID" id="1101786"/>
    <dbReference type="KEGG" id="sco:SCO6345"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6457"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047929_3_0_11"/>
    <dbReference type="OMA" id="WQYYAGG"/>
    <dbReference type="PhylomeDB" id="O86614"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030174877" evidence="3">
        <location>
            <begin position="31"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="252" mass="26220" checksum="9EF34598832790A2" modified="1998-11-01" version="1">MRMKRRVAAAVGALVAPVVALSLPAPTASAHGWVVSPGSRQDQCANRVVQCGQIKWEPASVEGPKGLRNCSGGDARWADLDDDGKGWRVTPIGTMHTFTWTIEARHATSNWQYFIGDQKIAQFDGHGALPPASVSHQLDFGGFSGRQKVLAVWNIADTANAFYACIDVNIGGGNDGGGDDGGGGDGDGDGGGDGGGDQPGDCVAGPWSAGSVYNGGETVSHDGHTWRAKWWVTGEEPGTTGEWGVWEDLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O86654</accession>
    <name>O86654_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5735</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T10930">
        <property type="entry name" value="T10930"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030427.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5735"/>
    <dbReference type="GeneID" id="1101174"/>
    <dbReference type="KEGG" id="sco:SCO5735"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5823"/>
    <dbReference type="eggNOG" id="ENOG502ZAY5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028325_1_0_11"/>
    <dbReference type="OMA" id="WGRFLEI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="5">
        <location>
            <begin position="96"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA20270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="491" mass="50578" checksum="BB9F4C0D093ADCA7" modified="1998-11-01" version="1">MKVSSTTATGFCRVTVVAPDARIDVALPVDLPVADLYPEILRLAQQTQSAGTPTGYHLVRRDGRVIDGARTLAEERVLDGEVLSLRPFAESLPPAVYDDVSDAVASAVVRDRHLWSDDLLRVAGLVGGALLVVMIGFVLWFADPLRHDMHGLPGIVAGGLGVLLTAFAGVRVRVYADRASATTLGLPALVLLLIAGSGIVGPDAGQGPGRLQFLLGCLTVLVASVVLVALAPSSDAPFVAATFLAAVGSLATFLAVVADATATETAAVCAPCAIGLVAFLPGMSARFARLPIGYAAPRSAAQDDFDPELAHGPEIGPLDAERIAAQARRGHELLLGLVGGTATVVVGAGAVLGFSDDVWAQLLALAVGLSMLIRARLFRYTSQVTCVLVAGLATIVLLLLGLALNPPTAALTEFVLHGDRGALDLRTIWLTAAIAAGAALITAVGLVIPRKGLSPFWGRLLDLTEGAVLLTLVPLCLAVLGVLAEVRSMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O86837</accession>
    <name>O86837_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5740</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35840">
        <property type="entry name" value="T35840"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629865.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973287.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5740"/>
    <dbReference type="GeneID" id="1101179"/>
    <dbReference type="KEGG" id="sco:SCO5740"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5828"/>
    <dbReference type="eggNOG" id="COG5010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123296_0_0_11"/>
    <dbReference type="InParanoid" id="O86837"/>
    <dbReference type="OMA" id="WFLWKNT"/>
    <dbReference type="PhylomeDB" id="O86837"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="16803" checksum="31742EAFBF3482C6" modified="1998-11-01" version="1">MRAKITYLVTAAVLVFYFLLVGSRGVLLIKTGTLLTVTFGVAVLILPVIGLWFLWKNTQFVRRANQLAAELDAEGGLPVDELKRTPSGRVDRESADAVFALRRAETEDAPGDWRSWFRLAVAYHDARDTPRARKAMQRAIALHDGKHVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O86838</accession>
    <name>O86838_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5741</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35841">
        <property type="entry name" value="T35841"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629866.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030429.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5741"/>
    <dbReference type="GeneID" id="1101180"/>
    <dbReference type="KEGG" id="sco:SCO5741"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5829"/>
    <dbReference type="eggNOG" id="ENOG502ZWB4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127148_0_0_11"/>
    <dbReference type="OMA" id="PYRPGPW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="20178" checksum="58806A19F8FD6996" modified="1998-11-01" version="1">MPLPFLTADRAFDTADDVALPYDDRDLWRRPYRPGPWRVGMAALMLLLASFVLFAAVIIAATGGLSSAGVVFGIAVVVILCALRMLRMGAWVSAHGVRQVGFFTTRTVAWQQVASLRTVQQPVRWLGLPRTVQGQALLLVRQGRSAEPLSPLLTSHNSDFLARDGAFNRAADAVEAWADEYRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKL8</accession>
    <name>Q7AKL8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3361</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36372">
        <property type="entry name" value="T36372"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627569.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975474.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKL8"/>
    <dbReference type="STRING" id="100226.SCO3361"/>
    <dbReference type="GeneID" id="1098798"/>
    <dbReference type="KEGG" id="sco:SCO3361"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3423"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_3_11"/>
    <dbReference type="InParanoid" id="Q7AKL8"/>
    <dbReference type="OMA" id="VSMRQED"/>
    <dbReference type="PhylomeDB" id="Q7AKL8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="150" mass="16870" checksum="B662AC3E3AD9D609" modified="2012-05-16" version="1">MDDVDRQILAELQKDGRLTLTELAERVRLSVSPCHRRLRALERSGAITGYHAALNAPALGLGFEALVFVTMRYEDRQTVAAFEAAVTEIPHVLQAQRLFGDPDYLLRVVTRDLEAYRRLYDERLASLPGVQRLSSTLVMANLVEARPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJZ6</accession>
    <name>Q8CJZ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-transporter integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2420</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAD55305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733570.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976386.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2420"/>
    <dbReference type="GeneID" id="1097854"/>
    <dbReference type="KEGG" id="sco:SCO2420"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2461"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_2_1_11"/>
    <dbReference type="InParanoid" id="Q8CJZ6"/>
    <dbReference type="OMA" id="LWIPRTL"/>
    <dbReference type="PhylomeDB" id="Q8CJZ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="268" mass="28479" checksum="60B53B05410B6C16" modified="2003-03-01" version="1">MASPLVWLDRSGDQLLFYVRALLWVPRTLRRYLKEVQRLLAEVAFGSGGLGVIGGTIGVMIAMTLFTGTVVGIQGYAALDQIGTSAFTGFVSAYFNTREIAPLVAGLALSATVGAGFTAQLGAMRINEEVDALEGMGIRSMPYLVTTRIIAGVVAIIPLYAIGLLSSFLASRYVTVLFNGQSRGTYDHYFNLFLSPTDVLLSVLKVLIFSVMVIVAHCYYGYRASGGPAGVGVAVGRSVRNAIVLISVTDFFLSLALWGATTTVKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK43</accession>
    <name>Q8CK43_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine N-alpha-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidine trimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">egtD</name>
        <name evidence="5" type="ordered locus">SCO0913</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:38471"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. EgtD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAD55449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733517.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027441.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0913"/>
    <dbReference type="GeneID" id="1096336"/>
    <dbReference type="KEGG" id="sco:SCO0913"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.907"/>
    <dbReference type="eggNOG" id="COG4301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049766_1_0_11"/>
    <dbReference type="InParanoid" id="Q8CK43"/>
    <dbReference type="OMA" id="RVEMHLV"/>
    <dbReference type="PhylomeDB" id="Q8CK43"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02037">
        <property type="entry name" value="EgtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032888">
        <property type="entry name" value="EgtD_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="4">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-histidine binding" evidence="3">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAD55449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="323" mass="34910" checksum="5A062F1B11904B4A" modified="2003-03-01" version="1">MSQFRLTRTLPEDATDAALRADVLAGLTSTPKWLPPKWFYDARGSELFEAITALPEYYPTRAEREILVDRAGEIAAATGARTLVELGSGSSEKTRVLLDALTERNGLRGYVPVDVSESALVQAGQALVAERPGLQVHALIADFTGGLTLPDTPGPRLVAFLGGTIGNLLPGERAEFLASVRSLLSPGDTLLLGTDLVKDEGVLVRAYDDAAGVTGEFNKNVLSVVNRELEADFAPAAFEHVALWNAEREWIEMRLRSRTAQAVKIQALDLAVDFADGEELRTEVSAKFRREGVRAELAAAGLDLAHWWTDGGDRFALSLSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IW0</accession>
    <name>Q93IW0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative cation efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO1310</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAC42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="sco:SCO1310"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1313"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_1_11"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
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    </dbReference>
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        <property type="term" value="F:cation transmembrane transporter activity"/>
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    </dbReference>
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        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
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    </dbReference>
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        <property type="term" value="F:zinc efflux active transmembrane transporter activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:cellular zinc ion homeostasis"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="363" mass="38443" checksum="38ED690A425B2F83" modified="2001-12-01" version="1">MSDPHRHHHAHHHRDHHDRPQDAHAHHDRSPAARWRRFAHLLAHRLTPHSHESADKLDPALEASARGLRALWVSLAVLGATALAQAAVVVASGSVALLGDTVHNTADALTAVPLAIAFVLGRRAATRRFTYGYGRAEDLAGIVIVLTIAASAVFAAWTAVDRLLDPRPVAHVPAVAVAALAGFAGNEWVARHRIRVGREIGSAALVADGLHARTDGYTSLAVLLGAGGAALGWRLADPVVGLAITAAIVLVLRDAAREVFRRLMDAVDPALVDRAERVLGEVPGVRGVGELRLRWIGHRLRAEVALVVDGEATVREAHRIAVAAEHALLHAVPRLSAALVHADPAPCPGEADPHLALAHHAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J37</accession>
    <name>Q93J37_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3969</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628152.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029347.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3969"/>
    <dbReference type="GeneID" id="1099405"/>
    <dbReference type="KEGG" id="sco:SCO3969"/>
    <dbReference type="eggNOG" id="ENOG50322PK">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651125_0_0_11"/>
    <dbReference type="OMA" id="EAHDGTG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="16637" checksum="CFA1391508918AE1" modified="2001-12-01" version="1">MPGRRRVRALPSHRHQRGVLAPLEDLVEAHDGTGPPRRTADVDVVGELPDEAQAATALRLRGRRATRAVRPARGGSGKTGARVGDLDPAPLAVQVGRDPVRLAGAVGAVVPAVLDGVRAGLAQRDGEVEGDVRVHARGLHGADQQAAGQGHARSLAPQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J58</accession>
    <name>Q93J58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0986</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC44336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625282.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027495.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0986"/>
    <dbReference type="GeneID" id="1096409"/>
    <dbReference type="KEGG" id="sco:SCO0986"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.984"/>
    <dbReference type="eggNOG" id="ENOG5031K6H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075566_1_0_11"/>
    <dbReference type="OMA" id="HAFFACA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176573" evidence="2">
        <location>
            <begin position="31"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC44336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="24445" checksum="6E68F5948C16E503" modified="2001-12-01" version="1">MADRGLLRAVRVAVFSLVCVLLAATGHAWAGGHRPPLALLALGGTAVAVTAGRLAGRERTLGQIAGAVTVTQGALHLLFALAGPAHPHVPASAQQGRHDQPAAHVAHMPHAGQHGSGVVTGAAETGAEPVGMTIAAAHLTPLMLLAHLVAGLGAAWWLRQGEALVWRLGRALGVPLSAVLHALVLLRRWSRYRAELSQRRVPPGFRAEREASCRTRVLRHALARRGPPVLFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J75</accession>
    <name>Q93J75_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2822</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAC44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627051.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975978.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2822"/>
    <dbReference type="GeneID" id="1098256"/>
    <dbReference type="KEGG" id="sco:SCO2822"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2880"/>
    <dbReference type="eggNOG" id="COG3473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068086_5_1_11"/>
    <dbReference type="InParanoid" id="Q93J75"/>
    <dbReference type="OMA" id="VWACTSG"/>
    <dbReference type="PhylomeDB" id="Q93J75"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="243" mass="25612" checksum="A251AAD5EE3F87D9" modified="2001-12-01" version="1">MTALGFLYPGHSGEDDYPRIEQLLGSDIRVDLVHTDIGEDAHRVDALLEMGSPRRLEAGVAELRLAGADAVVWACTSGSFVHGWDGAHAQVRALAQAAGLPASSTSFAFVHAAKELGVRRVSIGATYPDDVARLFGDFLGAAGIEVADVVSSGIITAAEVGTWTEAEVLALARAADRPDVEAVLLPDTALHTAAHIPALEKELGKPVLTANQVTIWEGLRLADRRVNAPELGALFTREPVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JJ3</accession>
    <name>Q93JJ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1968</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAC42742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626231.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028071.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1968"/>
    <dbReference type="GeneID" id="1097402"/>
    <dbReference type="KEGG" id="sco:SCO1968"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1994"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_1_11"/>
    <dbReference type="InParanoid" id="Q93JJ3"/>
    <dbReference type="OMA" id="FTDQINP"/>
    <dbReference type="PhylomeDB" id="Q93JJ3"/>
    <dbReference type="BRENDA" id="3.1.4.46">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176585" evidence="1">
        <location>
            <begin position="28"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="35"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC42742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="289" mass="31419" checksum="1C3B6FE284EC2B0B" modified="2001-12-01" version="1">MHVRAVAVTTTALLGVALTAPLSHARADEAGDDGPTVVAHRGASGYAPENTLAAVDRAAELGIRWVENDVQRTRDGELVVLHDESLARTTDVEEVFPDRSPWKVKDFTAAEIARLDAGSWFGSEYAGARVPTLEQYVHRVEHNHQKLLLELKSPGLYPGIEQQTLKVLANEGWLDRRHVAGRLVVQSFDADSIRTVHDLKPAVKTGFLGTPAVSELPAYAEFADQINPSYGSLSMSYVSAVHAFTGPHGRPLEVLTWTVNDADTARRVAGYDVDGIITNKPDVVRDAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK4</accession>
    <name>Q93JK4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4990</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629142.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973987.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4990"/>
    <dbReference type="GeneID" id="1100431"/>
    <dbReference type="KEGG" id="sco:SCO4990"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5071"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_1_11"/>
    <dbReference type="InParanoid" id="Q93JK4"/>
    <dbReference type="OMA" id="PAKFSHG"/>
    <dbReference type="PhylomeDB" id="Q93JK4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901565">
        <property type="term" value="P:organonitrogen compound catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC40603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="136" mass="14551" checksum="D2B4388CA9017EC2" modified="2001-12-01" version="1">MTDKIALVPATHTVPPAKFSHGVKKGNILQVAGQVGFLPHEEGKAPTPAGPTLREQTLQTLANVKAILEEGGASWDDVMMLRVYLTDVDHFAEMNEIYNAYFAEQGLTQPPAARTTVYVGLPAGLLIEIDALAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JK5</accession>
    <name>Q93JK5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative IclR-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4989</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629141.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973988.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4989"/>
    <dbReference type="GeneID" id="1100430"/>
    <dbReference type="KEGG" id="sco:SCO4989"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5070"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_0_11"/>
    <dbReference type="InParanoid" id="Q93JK5"/>
    <dbReference type="OMA" id="RYPVRMY"/>
    <dbReference type="PhylomeDB" id="Q93JK5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC40602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="254" mass="27923" checksum="E7773D18B2FB5248" modified="2001-12-01" version="1">MSQTVDRALSILPLLAEGPADLGRVADRLGVHKSTALRLLRTLHDHGFVYRQSDQRYRLGARLISLAQEAMENLDVREIAHPHLVRLNEQVGHTVHLAVHEEDEVLYIDKVESRYPVRMYSRIGKPVAITVAAVAKLLLADLPEDERRAVAEQLDYPMYTARSTPNADGFLKELAKVREQGWATDLGGHEESINCVAAPIRGADGRVVAAMSVSAPNVVVTADELLTLLPLVRRTADAISGEYSGRTPVKEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
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    <name>Q99Q07_STRCO</name>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="100226"/>
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            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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    </organism>
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    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
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                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639583.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639955.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039309.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095086"/>
    <dbReference type="GeneID" id="1095429"/>
    <dbReference type="KEGG" id="sco:SCP1.07c"/>
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    <dbReference type="HOGENOM" id="CLU_2345363_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="97" mass="10712" checksum="DFA6165992227526" modified="2001-06-01" version="1">MSACQSAAPRPAPPDDPVQRLAAYDQLAVSARDFLDRFHSKINGYRLPAEEGENPEDTDIDPAQYEAYDECRADYGEMAMHLMEAVAGHAPKERTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q34</accession>
    <name>Q99Q34_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.319c</name>
        <name evidence="1" type="ordered locus">SCP1.35</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="2" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">A3</strain>
            <plasmid evidence="3">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639611.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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    <dbReference type="Gene3D" id="3.40.50.10320">
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    </dbReference>
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        <property type="entry name" value="LmbE-like_dom_sf"/>
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        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="99" mass="10671" checksum="C653BE63B4E15884" modified="2001-06-01" version="1">MYLATHPHSAVPALRDVIGTRKAVYSVPDEQVTATVDVGPWMEQKTAAVLAHRSEVTRGALPGVIAGLPPDARHRLFATEWYIRHATITAGSAQTELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QJ9</accession>
    <name>Q99QJ9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="6" type="ordered locus">SCP1.285c</name>
        <name evidence="5" type="ordered locus">SCP1.68</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="journal article" date="2008" name="Proc. Natl. Acad. Sci. U.S.A." volume="105" first="17510" last="17515">
            <title>2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining.</title>
            <authorList>
                <person name="Corre C."/>
                <person name="Song L."/>
                <person name="O'Rourke S."/>
                <person name="Chater K.F."/>
                <person name="Challis G.L."/>
            </authorList>
            <dbReference type="PubMed" id="18988741"/>
            <dbReference type="DOI" id="10.1073/pnas.0805530105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="6">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639643.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1095368"/>
    <dbReference type="KEGG" id="sco:SCP1.285c"/>
    <dbReference type="KEGG" id="sco:SCP1.68"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8017"/>
    <dbReference type="HOGENOM" id="CLU_048975_1_2_11"/>
    <dbReference type="OMA" id="HAMRWPD"/>
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        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
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        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="4">
        <location>
            <begin position="53"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC36590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC36811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="33331" checksum="322C2B46F509028F" modified="2001-06-01" version="1">MPRTIWSGAISFGLVTVPIHVVSATEDHSIHFHRVHLEDMARVRTRKVCELEDREVASSEIGKGYELSKTQVIPISDEELRDLPLPTARAIEIVAFMPWESIDSLRIGDGYYLAPDGQVAAKPYKLLRQALDRSSRVAVARYAWSGRERLGLLRVRGEAIVLHAMRWPDEIRDPSELTPPPVELTDEEIDGALALMDTMTRDDLDAPEFRDTYTEAVAELIEAKREHRQPPAAPEPAAESGQLVDLMAALQQSVSKAKESRGEDPGHADVHSMPKRTAKKQPAKKATAKKASRKPRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACX5</accession>
    <name>Q9ACX5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative large membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCP1.176</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639754.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095254"/>
    <dbReference type="KEGG" id="sco:SCP1.176"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8122"/>
    <dbReference type="HOGENOM" id="CLU_005332_0_0_11"/>
    <dbReference type="OMA" id="RQCLEYC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="270"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1203" mass="126149" checksum="089158AB5B515EB1" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD59</accession>
    <name>Q9AD59_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.91c</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639664.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039390.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095169"/>
    <dbReference type="KEGG" id="sco:SCP1.91c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8039"/>
    <dbReference type="HOGENOM" id="CLU_063236_8_0_11"/>
    <dbReference type="OMA" id="TIGYEYQ"/>
    <dbReference type="PhylomeDB" id="Q9AD59"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="252" mass="27221" checksum="75A0366859B5D576" modified="2001-06-01" version="1">MPGPPRADNRPPYARIASHYRDLINSGGLSPGDLLPSIKSLAAEWKVSTATADRAMRLLREEKLVQGIPGVGTEVMERPISLSNGAERHDRSGKTQSSWGVGEKSSGHTAGIVEAPEDVADVLGISPGDDVIRRSRVYRDGHGIVSHSTSWIPAEFAQAVTELARSERLKGGLSLDLIARATGRRVVKRVDEESARIATTRDLELLELEADTVAAILVLTARFLDADGELLEYGVDLGAPGRTRRTTTEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADA9</accession>
    <name>Q9ADA9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate_red_gam domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO0518</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58278.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624832.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027178.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0518"/>
    <dbReference type="GeneID" id="1095941"/>
    <dbReference type="KEGG" id="sco:SCO0518"/>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186197_0_0_11"/>
    <dbReference type="PhylomeDB" id="Q9ADA9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019645">
        <property type="term" value="P:anaerobic electron transport chain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Nitrate_red_gam" evidence="7">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB58278.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="86" mass="9502" checksum="7A9FBCF466863A1C" modified="2001-06-01" version="1" fragment="single">MVLALPAGGGYDYRGTVSVWFRGLFALGPRPEVIAYAPLLFRPHAPSACLLFAARPFTRLVHVWSAPVGYLVRPCSVHRRRATPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADH8</accession>
    <name>Q9ADH8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6085</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630193.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030643.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6085"/>
    <dbReference type="GeneID" id="1101526"/>
    <dbReference type="KEGG" id="sco:SCO6085"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6187"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056518_0_0_11"/>
    <dbReference type="OMA" id="TNNAVFA"/>
    <dbReference type="PhylomeDB" id="Q9ADH8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="288" mass="31280" checksum="74B6AA0C97A22024" modified="2001-06-01" version="1">MDEARAREVLAAAGVLPGPASEARLLALGENAVFAAGDLAVKVGRDAELLGRARRELAVALWLEEAGVPAVRAAEPTALFVDGHPVTVWRRLPEPVRPTEPRDVAALLRLVHELALPSSFELPPRDLLGGVERWLRLAGDVIDPADAAYLRQRRDGFASAAAALAPHLTPGPIHGDALPRNVHVGPDGPVLIDLETFSADLREHDLVVMALSRDRYGLPAEAYDAFTATYGWDVREWDGCAVLRGARETASCAWVAQHAPSNPKALAEFERRVASLRDEDPEVRWYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK16</accession>
    <name>Q9AK16_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO7712</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC22720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631750.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031847.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7712"/>
    <dbReference type="GeneID" id="1103150"/>
    <dbReference type="KEGG" id="sco:SCO7712"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7832"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_11"/>
    <dbReference type="InParanoid" id="Q9AK16"/>
    <dbReference type="OMA" id="DLIAGVH"/>
    <dbReference type="PhylomeDB" id="Q9AK16"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC22720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="226" mass="23075" checksum="BE86B4BA1189D419" modified="2001-06-01" version="1">MIRVLIADDEPMIRAGVRAVLATAADIDVVAEAADGHDAVELVRRHRPAVAVLDIRMPGLNGIDAAAEIRTAVPGTGVIMLTTFGEDDYILQALGGGAAGFLIKSGEPEELLTGVRAVAGGAAYLSPRVAARVVAHLAATGAGTLAGRRSAARDRVAALTAREREVLALLGAGLSNGQIARRLHVVEGTVKAHVSSLLARLGVDNRAAAAVVAHEAGIIAPQPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK40</accession>
    <name>Q9AK40_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4886</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAC33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629039.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974086.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4886"/>
    <dbReference type="GeneID" id="1100327"/>
    <dbReference type="KEGG" id="sco:SCO4886"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4966"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_11"/>
    <dbReference type="InParanoid" id="Q9AK40"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="PhylomeDB" id="Q9AK40"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="252"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="537" mass="57490" checksum="CFB12C06EABE6711" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK65</accession>
    <name>Q9AK65_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glucose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4052</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628234.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974911.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4052"/>
    <dbReference type="GeneID" id="1099488"/>
    <dbReference type="KEGG" id="sco:SCO4052"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4114"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_11"/>
    <dbReference type="InParanoid" id="Q9AK65"/>
    <dbReference type="OMA" id="DMWAYND"/>
    <dbReference type="PhylomeDB" id="Q9AK65"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="27533" checksum="70D31E10F0B10308" modified="2001-06-01" version="1">MTPAPRSAASTHLLDGRIALVTGAGGGIGRGIALRFAEEGAAVAVHCRTTVESAREVAERIRGRGGRATVLRADLTDEDACRRLVGEAAEWGGGRLDALVNNAGVQPLRELPGMTATEWRAVVDTNLTGVFACTQAAAAVMRAQDGGGTVTHIASIEARAPAPAHAHYSASKAAVVMHARSAALEYGPWGVRVNSVSPGLVDREGLAEAWPEGVRRWRRAAPTGRLGRPEDVGDACVFLASRLASWVTGHDLVVDGGVTARPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWF2</accession>
    <name>Q9EWF2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4946</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629098.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974027.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4946"/>
    <dbReference type="GeneID" id="1100387"/>
    <dbReference type="KEGG" id="sco:SCO4946"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5026"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_5_1_11"/>
    <dbReference type="InParanoid" id="Q9EWF2"/>
    <dbReference type="OMA" id="INNIAWL"/>
    <dbReference type="PhylomeDB" id="Q9EWF2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="28108" checksum="D0F371787D64EF23" modified="2001-03-01" version="1">MTYHASTPSTPLLVTGGTGTLGGHVVPLLREAGHDVRVLTRRTRPATGNGITYVTGDLRTGEGVEAAVDGVHTVLHLAGGPKGDDEATRTLVRAAARADVRHLAYISVVGADRVPLAWLRTKLESERAIADSGLGWTVLRAAQFHELTLTMIEKMTRLPVLPVPGGLRLQPVAAREVAVRLAELTLAEPSGRVPDMTGPEVLDLATLAHSYLDLRGGRRRPKLPVRIPGKAGRAYRSGQNLTLEDALVGKVTWTEFLAERAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWG6</accession>
    <name>Q9EWG6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4970</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAD30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629122.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029979.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4970"/>
    <dbReference type="GeneID" id="1100411"/>
    <dbReference type="KEGG" id="sco:SCO4970"/>
    <dbReference type="HOGENOM" id="CLU_3123013_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="50" mass="5149" checksum="078369214E0896BC" modified="2001-03-01" version="1">MKEKPGMCHTGAQRNGVSAAVRDPARNPHGAAGEATQVRVGAHLPVASCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2M6</accession>
    <name>Q9F2M6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3755</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627945.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029214.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3755"/>
    <dbReference type="GeneID" id="1099191"/>
    <dbReference type="KEGG" id="sco:SCO3755"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3815"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_11"/>
    <dbReference type="InParanoid" id="Q9F2M6"/>
    <dbReference type="OMA" id="NICKFYS"/>
    <dbReference type="PhylomeDB" id="Q9F2M6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC10293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="264" mass="27442" checksum="13C7EE5224BAFB70" modified="2001-03-01" version="1">MDHRPEVPAATPGLAVELRGVQRRYGRGAGTVHALAGIDLALPRGTFTAVMGPSGSGKSTFLQCAAGLDRPSAGSVRLGGTEITGMNENELTELRRSRLGFVFQAFNLLPSLTVEQNVLLPMRLAGQRQDHRRAADVLAQVGLADKARRRPGELSGGQQQRVAVARALVTAPDVIFADEPTGALDTGTAAEVLGLLRQAVDGLGATVVMVTHDPAAAAWADRVLFLADGAFADHLERGSAEQIAARMTALTGRARATAAAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2P8</accession>
    <name>Q9F2P8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3101</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAC09542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627319.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975710.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3101"/>
    <dbReference type="GeneID" id="1098535"/>
    <dbReference type="KEGG" id="sco:SCO3101"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3164"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087613_0_0_11"/>
    <dbReference type="OMA" id="NPRYGTW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176662" evidence="1">
        <location>
            <begin position="24"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC09542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="215" mass="23506" checksum="EFFB96F96B402364" modified="2001-03-01" version="1">MHRRRRSALLLTAAIAAAAPLLAACGNDAHPGAAAVVGDQRITVAQLENRVDEVREAQRAAVPDDTQYQQVVARTGTLTRDTLHGMVLDRVLHRAAQDAGVTVSRKEVQDMRGELEKQAGGPEQLETVWLQQYGVAPDRLDDNLLVQIEAQKLAQSLGTDTSRPEFWQALSEASKKLGVDLNPRYGAWDVQKSSRVDTRTPWVREITAAGSQQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2S7</accession>
    <name>Q9F2S7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4462</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628628.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029671.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4462"/>
    <dbReference type="GeneID" id="1099902"/>
    <dbReference type="KEGG" id="sco:SCO4462"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4532"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035309_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F2S7"/>
    <dbReference type="OMA" id="MSSWVTR"/>
    <dbReference type="PhylomeDB" id="Q9F2S7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="9"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC08369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="415" mass="41778" checksum="95052277E436FEB3" modified="2001-03-01" version="1">MTDRAVQRRRRALYLFFFLNGIAMSSWVTRTPDIRDRLGVSTAQMGLVLFGLSVGSMTGILCSGRLVSRFGTRPVTAVGTLLIVASVAVVGAGSALASAPLVTAGLCLFGVGAGAGEVAINVDGADVERITGRPVLPTLHGCFSLGTVVGALAGMAATAAAFPAHWHLSAVAVVAAGIFTYAIGAVPAGTGIRAAPPAPGSAGPSKPQVWRDRRLLLIGAIVLAMALAEGAANDWLPLLMVDGHGLDAAAGSLVYVGFAAAMTLGRFGGTFFLSRHSRATVVRASAVSGALGLCLVIFSDNTVVAAAAVLFWGLGASLGFPVALSAAGDSGPAETARVGLVATIGYIAFLVGPPTLGFLGDHYGLRPAMVVVLAFVAAAAFAAPAAGTRGSRHHGADTRTPAEPAAERSAQRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2Y8</accession>
    <name>Q9F2Y8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO4359</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628529.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029602.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4359"/>
    <dbReference type="TCDB" id="3.A.1.105.13">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099799"/>
    <dbReference type="KEGG" id="sco:SCO4359"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4427"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9F2Y8"/>
    <dbReference type="OMA" id="RHLVWQR"/>
    <dbReference type="PhylomeDB" id="Q9F2Y8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="36604" checksum="69496906E1E2845B" modified="2001-03-01" version="1">MSERHAVRAEGLEKRYGDKRALDGFDLTVREGTVHGLLGPNGAGKTTAVRILSTLIRLDGGRAEVAGLDIARQAREVRARIGLTGQYAAVDEVLTGRQNLEMFGRLFHLGGRRARARAVELLEQFDLTDAADRGVGKYSGGMRRRLDLAASMILAPSVLFLDEPTTGLDPRSRGEVWESVRELVASGTTVLLTTQYLEEADKLASRITVIDRGRAIADDTPDGLKNLVGGDRIEVVVADHAEIPRVVKTVARVCKGEPEVEEEALRVHAPVTDRVPALTEVARTLQDEGVAVEDIGLRRPSLDDVFLRLTGHRTSVQPARNAENEKEKKTKEAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3D5</accession>
    <name>Q9F3D5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">SCO7622</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631663.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031783.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7622"/>
    <dbReference type="GeneID" id="1103060"/>
    <dbReference type="KEGG" id="sco:SCO7622"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7740"/>
    <dbReference type="eggNOG" id="COG1282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007866_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F3D5"/>
    <dbReference type="OMA" id="AMTSMPE"/>
    <dbReference type="PhylomeDB" id="Q9F3D5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="6"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAC16724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="483" mass="50325" checksum="E5C7F510B6B059E5" modified="2001-03-01" version="1">MTASRAADLVAALLFVLSLAGLSQHRTSRAGVVYGIAGMALALAATVVVSARSVSAGPVALILLATVIGAAVGLWRARRVEMTQMPELIAVLHSFVGLAAVLVGWNSYLEVEAHGSRGRIAADLIGIHHAEVFIGVFIGAVTFTGSVVAYLKLSARIKSRPLTLPGKNALNLGALALFAVLTVWFTVSPGLPLMVAVTVLALALGWHLVASIGGGDMPVVVSMLNSYSGWAAAAAGFLLDNNLLIVTGALVGSSGAYLSYIMCQAMNRSFLSVIAGGFGIEAPPGGAQEQGEHREVRAPEAAELLARARSVVITPGYGMAVAQAQHPVAELTRRLRERGVEVRFGVHPVAGRLPGHMNVLLAEAKVPYDVVLEMDEINDDFADTSVVLVIGANDTVNPSATDDPASPIAGMPVLRVWEAEQVVVFKRSMASGYAGVQNPLFFRDNTSMLFGDAKQSVEAILEALGSGTGRDPRAAARGATAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3N7</accession>
    <name>Q9F3N7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7650</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631690.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031804.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7650"/>
    <dbReference type="ESTHER" id="strco-SC10F4.23">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1103088"/>
    <dbReference type="KEGG" id="sco:SCO7650"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7770"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_2_11"/>
    <dbReference type="InParanoid" id="Q9F3N7"/>
    <dbReference type="OMA" id="YDVTAMR"/>
    <dbReference type="PhylomeDB" id="Q9F3N7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176687" evidence="2">
        <location>
            <begin position="30"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="388"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC16983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="490" mass="52810" checksum="851AE3D049F3F1B6" modified="2001-03-01" version="1">MRRSLSLALTATALAVTALPASATPPAAATTASAPDALRWGPCPEGAAAPRLRCSTLRVPLDYRDPDGRRIEIAVSRLASEKPAQRRGVLLTNPGGPGGSGLVYPAVLAASGLPQEVLDSYDIIGFDPRGVGRSTPVTCDLTQEQQWRGNFPPYAHTAADVTREAGNARKIAEQCGDSRTAWMLPHTTTANTARDMDRLRTALGEPKLSYLGASYGSYLGAVYATLFPRRGDRIVLDSNMGPGGYDVTAMRLFARGLEDRFPDFAAFAVAHPEYGLGSTREEVTDTYFELAERLDEKPYQDVDGTAFRGYTFDSLYADASMPRLAEFWQAVDTGGPLPLPEPPPGLENLMAARFAVVCGDSRWPGTIREYQRNVAVDRHRYPMLGGSTASINPCAFWPREGTEPPVRITGRGPSNVLMLQNERDPGTPLAGARELRRAFGGRATMVTADQGGHGVYPYGRNTCANDAATRFLTTGERPARDLACAARPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3Q6</accession>
    <name>Q9F3Q6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7631</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631671.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031789.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7631"/>
    <dbReference type="GeneID" id="1103069"/>
    <dbReference type="KEGG" id="sco:SCO7631"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7750"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018576_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F3Q6"/>
    <dbReference type="OMA" id="HDQIFLT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176689" evidence="1">
        <location>
            <begin position="43"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="62"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="629" mass="68258" checksum="42FAF4B14BF983F8" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC50</accession>
    <name>Q9FC50_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7136</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631197.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031453.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7136"/>
    <dbReference type="GeneID" id="1102574"/>
    <dbReference type="KEGG" id="sco:SCO7136"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7237"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_5_1_11"/>
    <dbReference type="InParanoid" id="Q9FC50"/>
    <dbReference type="OMA" id="HHVLLSI"/>
    <dbReference type="PhylomeDB" id="Q9FC50"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="247" mass="25966" checksum="3C1B01BD0D7BDB13" modified="2001-03-01" version="1">MRVAVAGGTGLVGKYVVAELRAAGHTPVVLARSHGVDLTTGAGLAGKLSGSDAVIDVANIVTTRRKTAVDFFSRTTGHLIAAARAGGVAHLVTLSIVGSDEVDFGYYFGKRAQEELVRDGAVPWTVVRATQFFEFPEPLLNGVSPVVVVPRMLTRPVAAQDVAQTLVEHAVEGPAGMAPEIAGPDQLDMVDMARRIARARGSRRLVVPVTLPGKVGKAMTTGGLLPRGEYLRGRRTFDAHLASLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCF7</accession>
    <name>Q9FCF7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4213</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628388.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029505.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4213"/>
    <dbReference type="REBASE" id="6117">
        <property type="entry name" value="ScoA3Mrr"/>
    </dbReference>
    <dbReference type="GeneID" id="1099653"/>
    <dbReference type="KEGG" id="sco:SCO4213"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4276"/>
    <dbReference type="eggNOG" id="COG1787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032125_1_0_11"/>
    <dbReference type="OMA" id="FRAMGMQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015666">
        <property type="term" value="F:restriction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="3">
        <location>
            <begin position="411"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC04049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="544" mass="61219" checksum="4E825C3B81C70486" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCG1</accession>
    <name>Q9FCG1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4208</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAC04044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4208"/>
    <dbReference type="GeneID" id="1099648"/>
    <dbReference type="KEGG" id="sco:SCO4208"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4272"/>
    <dbReference type="eggNOG" id="COG2814">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_11"/>
    <dbReference type="InParanoid" id="Q9FCG1"/>
    <dbReference type="OMA" id="TVCVWTL"/>
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    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC04044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="44895" checksum="3FB961F3AD69DC10" modified="2001-03-01" version="1">MPVAGLGRAARETVSGLPRAFWWLWTSTLVNRLGAFVATFMALYLTIDRGYSASYAGLVAALHGLGGVVSSLGAGVMTDRLGRRPTLLVAQTSTALSVALLGFMRDPVAIAAVAFLVGMASNASRPAVQAMMADIVRPEDRIRAFSLNYWAINLGFAISSMAAGFIAEYSYLAGFMIEAGMTLVCAVLVFVKLPESRPKEHAAETSGGGDAVPVSLGTVLRDGRYMGVVGLSFLIALIFQQAYVGLPVAMGEAGFTPADFGMAIAVNGVLIVVLQIPVTRFIQHRDPRLLLIGSALLAGYGFGLTAFAGSVAVFALTVCVWTLAEVVNAPTQTGLVVRLSPVHGRGRYQGMYSMSWAVAALVAPLMSGFVIDHWGAEWLWGICAVVGTVAAAGYWGLMRGLPNGGDGDETPVAQDTSAAPVPRADTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCK2</accession>
    <name>Q9FCK2_STRCO</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="CAC01316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030105.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5186"/>
    <dbReference type="GeneID" id="1100627"/>
    <dbReference type="KEGG" id="sco:SCO5186"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5270"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_4_11"/>
    <dbReference type="InParanoid" id="Q9FCK2"/>
    <dbReference type="OMA" id="HIRRCPA"/>
    <dbReference type="PhylomeDB" id="Q9FCK2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NADH_PPase-like_N"/>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
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        </location>
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        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09297"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC01316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="318" mass="34984" checksum="6B562BF422C00317" modified="2001-03-01" version="1">MEAPVTTWTDHTADRPISLTAPSGVDRAAHHRLDEAWLAAAWSHPSTRCFVVSGGQVLIDETPDGATELVMTPSFEAPLTEAHRYFLGTDEDGTSYFALQKDSLPGRMDQSARPAGLREAGLLLSPRDAGLMAHAVALENWQRLHRFCSRCGERTVIAAAGHIRRCPACGAEHYPRTDPAVIMAVTDGEDRILLGRQVHWARGPLLDPRRFRGARRVHRAVGAPRGPGGGRRHRRPGRVRREPAVAFPSSLMLGFMAHATSTEIDVDGDEIHEARWFSREELGAAFESGEVLPPYGISIAARLIELWYGRPLPTRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K413</accession>
    <name>Q9K413_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1320"/>
    <dbReference type="GeneID" id="1096743"/>
    <dbReference type="KEGG" id="sco:SCO1320"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1323"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068637_2_0_11"/>
    <dbReference type="InParanoid" id="Q9K413"/>
    <dbReference type="OMA" id="HLEFEYT"/>
    <dbReference type="PhylomeDB" id="Q9K413"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB95777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="281" mass="29603" checksum="E21EE14018032865" modified="2000-10-01" version="1">MNEAIPVSRVTDHGTAKLMPDVDRARAWLLTVDGAPQSYVDLDEPAHLEFEYTRRLGHVLDTVAEPGRTLDVLHLGGGAFTLPRYVAATRPGSRQDVVEADRGLLDLVAEHLPLPPGAGITAHGADARAWLSAAPADSADVLVADVFGGSRVPAHLTSLGYVREAARVLRADGVYVANLADGAPFGFLRGQLAGFAAFFEELALIAEPGVLRGRRFGNAVLVAAHRPLDTAALARRTAADAFPARVEHGPALRDFVGDARPVRDEDAVPSPEPPAGAFGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY39</accession>
    <name>Q9KY39_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2351</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626598.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976453.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2351"/>
    <dbReference type="GeneID" id="1097785"/>
    <dbReference type="KEGG" id="sco:SCO2351"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2389"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_2_0_11"/>
    <dbReference type="OMA" id="WLGATWL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB92827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="21552" checksum="7182C6A513F1D943" modified="2000-10-01" version="1">MVEGLGSIGSLVSSPWIYVLVGASVLLDIFLPVLPSGVLVITAATAAAAGSGAAAAGRVPEDVPDILVLTLCAATASVVGDLAVYRLAWRGGARLDRAIARSRRLTTAQERLGGALARGGGALVVLARFAPAGRSVVSLVAGAAHRRVREFLPWSALAGLAWAAYSVALGYFGGQWLGATWLATGVSLVALFGAGAAAAYLMRRQPRTTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY92</accession>
    <name>Q9KY92_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5010</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629162.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030000.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5010"/>
    <dbReference type="GeneID" id="1100451"/>
    <dbReference type="KEGG" id="sco:SCO5010"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5089"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076894_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KY92"/>
    <dbReference type="OMA" id="FLNWQRQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="149"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB92603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="316" mass="33722" checksum="A8834DAAA7B7A894" modified="2000-10-01" version="1">MEPELDTLVTLTTGVTLLTCVLAIVGLHSYAAGKAQRAALVDRLTATGQAPSAGRRRRFPTLDRRLRRTGLGRNLERRLSATGLDVTPGEFFAYMLATVAGLWLIGQAALAPFFGPLAGLLGIGVAIQFLNWQRQKRIEKFINQLPELARILANATQAGLALRTAIGMAAEELEAPAGEELGKVADQLAIGASMDDALGELAGRLPSRELVVLVTTLVLSNRAGGQVVGALRNLTETLEERKETRREVRTQLSQVTMTSYAVPVLGIGSLLLMNGVKDGALERMTGSPAGQAAVITAFALYAVGFVLIRRLSRIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYP0</accession>
    <name>Q9KYP0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative asnC-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4493</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB92114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628658.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029693.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4493"/>
    <dbReference type="GeneID" id="1099933"/>
    <dbReference type="KEGG" id="sco:SCO4493"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4563"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KYP0"/>
    <dbReference type="OMA" id="EDCWFIA"/>
    <dbReference type="PhylomeDB" id="Q9KYP0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB92114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="17919" checksum="A6EBE3CF89F781DB" modified="2000-10-01" version="1">MLPTSSELFSGRLRSHGRGGQAAHPGPEENGRASYAELGRLVGLSGPSVTDRINRLEAAGVITGYRATVDSASLGLGVTALIGVSLSDAADHEDVAQRLKELREIEDCWFIAGDDSYMLKVRAADVDGLESIIRRLSGTKGVSRTRTTIVLSTKWENRVGELPEEVQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-01-25" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYV7</accession>
    <name>PNPH_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO3188</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627402.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975629.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9KYV7"/>
    <dbReference type="SMR" id="Q9KYV7"/>
    <dbReference type="STRING" id="100226.SCO3188"/>
    <dbReference type="GeneID" id="1098622"/>
    <dbReference type="KEGG" id="sco:SCO3188"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3248"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_11"/>
    <dbReference type="InParanoid" id="Q9KYV7"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="PhylomeDB" id="Q9KYV7"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000415083" description="Purine nucleoside phosphorylase">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="55"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <sequence length="280" mass="29755" checksum="CA99954C27D27D8A" modified="2000-10-01" version="1">MANKVKAEIGVIGGSGFYSFLDDVTEVRVDTPYGPPSDSLFLGEVAGRRVAFLPRHGRGHHLPPHRINYRANLWALRSVGARQVLGPCAVGGLRPEYGPGTLLVPDQFVDRTRSRPSTYFDGLPMPDGTVPNVVHVSLADPYCPTGRAAALKAARGREWEPVDGGTLVVVEGPRFGTRAESLWHRAQGWSVVGMTGHPEAALARELELCYTSLTLVTDLDAGAESGEGVSHEEVLRVFAANVDRLRGVLFDAVAALPASGERDCPCGAALGGMDPGIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ17</accession>
    <name>Q9KZ17_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2220</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626471.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028207.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2220"/>
    <dbReference type="GeneID" id="1097653"/>
    <dbReference type="KEGG" id="sco:SCO2220"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2257"/>
    <dbReference type="eggNOG" id="ENOG5033RDI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017313_0_0_11"/>
    <dbReference type="OMA" id="RYLTAPW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB90868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="643" mass="66538" checksum="1217A5C88E3CD419" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ46</accession>
    <name>Q9KZ46_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7086</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAB89758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631147.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972058.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7086"/>
    <dbReference type="GeneID" id="1102524"/>
    <dbReference type="KEGG" id="sco:SCO7086"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7188"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_3_11"/>
    <dbReference type="InParanoid" id="Q9KZ46"/>
    <dbReference type="OMA" id="TQMPIAK"/>
    <dbReference type="PhylomeDB" id="Q9KZ46"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB89758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="115" mass="12956" checksum="2D4C00C76DF1D50E" modified="2000-10-01" version="1">MTTLTPAAAADRTGVSIDTLRYYEREGLIGPVRRSTGGRREYTEEDVFWIGLVTCFREAGLGIADLRGFVAILRGEHSPQDRVAFLRERRTALEQRVAALCRAMEVLDDKIAYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZQ5</accession>
    <name>Q9KZQ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2898</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627124.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975912.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2898"/>
    <dbReference type="GeneID" id="1098331"/>
    <dbReference type="KEGG" id="sco:SCO2898"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2957"/>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133067_1_3_11"/>
    <dbReference type="InParanoid" id="Q9KZQ5"/>
    <dbReference type="OMA" id="EVFWVIG"/>
    <dbReference type="PhylomeDB" id="Q9KZQ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="106" mass="10962" checksum="B7DDFABDCB24206A" modified="2000-10-01" version="1">MAWVLLFVAGLLEVGWSIGMKYTDGFTRLWPSVFTGAGIVASMMLLSYAARTLPIGTAYGVWVGIGAAGAAVLGMVVLGEPATAARIFFICLLLVAVVGLKATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZY1</accession>
    <name>Q9KZY1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4445</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB88452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628612.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029658.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4445"/>
    <dbReference type="GeneID" id="1099885"/>
    <dbReference type="KEGG" id="sco:SCO4445"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4515"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063235_0_1_11"/>
    <dbReference type="OMA" id="YPPREIS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="235"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="327" mass="34984" checksum="1967884F775CDFFC" modified="2000-10-01" version="1">MGWWEINADTLARGRFVVSPLDETLACLKMLHAGVAGHPGERAWLDTHRPAHLRRMAADPVTALLVASGLGREWNADFLTPTPVEGQSFADGVARIRAARPEVARADLAVSLGGTLPAALDRDDLPERAAALLEEVWAEAVRPDWDRRRRVLEADVVARTAQVSRGGWATVLDALRPGTRWLGDNRLQINLNPYPPRELSGAELLLVPITPQRHGWVAWEEPERYAMVYPCAGALADDGARHVPAALGALLGPARAGVLTLLGTPMSTSQLVGVTGQGLGSVGRHLRVLLEAGLVERRRAGRSVLYSRTPAGEVLVEAGAGSGTGPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0H2</accession>
    <name>GUAA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber>6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">guaA</name>
        <name type="ordered locus">SCO4785</name>
        <name type="ORF">SCD63.17</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2"/>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628943.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974187.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0H2"/>
    <dbReference type="SMR" id="Q9L0H2"/>
    <dbReference type="STRING" id="100226.SCO4785"/>
    <dbReference type="MEROPS" id="C26.A07"/>
    <dbReference type="GeneID" id="1100226"/>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.4859"/>
    <dbReference type="eggNOG" id="COG0518">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glutamine metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
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    <dbReference type="InterPro" id="IPR022955">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000140186" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase">
        <location>
            <begin position="205"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="232"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <sequence length="526" mass="56613" checksum="43ACC404EE19EEA3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Q4</accession>
    <name>Q9L0Q4_STRCO</name>
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        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">SCO4237</name>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        </lineage>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_011029525.1">
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    </dbReference>
    <dbReference type="STRING" id="100226.SCO4237"/>
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    <dbReference type="KEGG" id="sco:SCO4237"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4300"/>
    <dbReference type="eggNOG" id="COG5602">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036900_0_0_11"/>
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    <dbReference type="Proteomes" id="UP000001973">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="256"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="422"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="562"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB77331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="571" mass="58652" checksum="2D702C172862F59B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0V9</accession>
    <name>Q9L0V9_STRCO</name>
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        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3745</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627936.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029205.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3745"/>
    <dbReference type="GeneID" id="1099181"/>
    <dbReference type="KEGG" id="sco:SCO3745"/>
    <dbReference type="eggNOG" id="ENOG5032Y3E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121462_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0V9"/>
    <dbReference type="OMA" id="PAVPWIN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="17662" checksum="741465E146A0A4A7" modified="2000-10-01" version="1">MKRVRELRGRRGLRPGIGSPFQILLLACSFALAGYAGVRLLADDWLGVALWFVGAALLHDLVLLPLYSVLDRAVTGGLGAARHREWTSYVRFPAALSGLLLLVWFPLIGGRVDASYQGVTGLSADGFLARWLLVTAVLFGGSALLLALRLLRSATKRRSPDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0Y0</accession>
    <name>Q9L0Y0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3724</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB76971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627915.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975216.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3724"/>
    <dbReference type="GeneID" id="1099160"/>
    <dbReference type="KEGG" id="sco:SCO3724"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3784"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_7_1_11"/>
    <dbReference type="OMA" id="VFAVHDR"/>
    <dbReference type="PhylomeDB" id="Q9L0Y0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="36"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="16790" checksum="DA5F020313B9D273" modified="2000-10-01" version="1">MLGPRVRGQPRTGFPCGDAMSTLLQPMPHRHVLTLPAAPPAVRLARETAEQALAEWGVNPGHPAVAPALLILSELVTNSVRHASPPSEQVTVTYAAGDDCLAFAVHDRHPHQPRLHGARTTGRTGGLATVMELTGTLGGTAVVRGDGDGRGKSIWVTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L219</accession>
    <name>Q9L219_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ArsR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6813</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630885.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007445855.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6813"/>
    <dbReference type="GeneID" id="1102252"/>
    <dbReference type="KEGG" id="sco:SCO6813"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6922"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_11"/>
    <dbReference type="InParanoid" id="Q9L219"/>
    <dbReference type="PhylomeDB" id="Q9L219"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="113" mass="12217" checksum="B2FB4DCCE299E714" modified="2000-10-01" version="1">MCQKGAGSACDGTCLELTAADMVWWSNVFKTLGDPVRLQLLMKLAERSGGEAAVHELADVGVSPATVSHHLKRLRCIGLIESRRDGRLVYYKLGAGVRAALMQILHQRSQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9R3R2</accession>
    <name>Q9R3R2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2935</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36158">
        <property type="entry name" value="T36158"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627161.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975875.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2935"/>
    <dbReference type="GeneID" id="1098368"/>
    <dbReference type="KEGG" id="sco:SCO2935"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2993"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_5_4_11"/>
    <dbReference type="OMA" id="VNRTVVY"/>
    <dbReference type="PhylomeDB" id="Q9R3R2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB51016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="23068" checksum="4F3EEE45D4952897" modified="2000-05-01" version="1">MTAETSQTLDRGLRVLKLLADTDHGLTVTELSHKLGVNRTVVYRLLATLEQHALVRRDLGGRARVGLGVLGLGRQVHPLVREAAMPALRALAEDIGATAHLTLVDGAEALAVAVVEPTWTDYHVAYRAGFRHPLERGAAGKAILAARQPSQPTGGEAVDDPGYTLTHGELEAGACGAAAPLLGVTGVEGSVGVVMLADVVPERVGERVKHAAREVAEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD29</accession>
    <name>Q9RD29_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0881</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625180.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027413.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0881"/>
    <dbReference type="GeneID" id="1096304"/>
    <dbReference type="KEGG" id="sco:SCO0881"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.872"/>
    <dbReference type="eggNOG" id="COG1741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RD29"/>
    <dbReference type="OMA" id="HMGLQTV"/>
    <dbReference type="PhylomeDB" id="Q9RD29"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin_C" evidence="4">
        <location>
            <begin position="193"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="321" mass="35104" checksum="A535B1261554136F" modified="2000-05-01" version="1">MSNLDREAVPSPCGGRGFVVTEPVRELLSPRNVKLGESTEVRRLLPNLGRRMVGAWCFVDHYGPDDIADEPGMQVPPHPHMGLQTVSWLHEGEVLHRDSTGSLQTIRPRQLGLMTSGRAISHSEESPRPHARLLHGAQLWVALPDAHRHTDPHFEFHAELPRVTAPGLAATVLLGTLDTATSPGTTYTPLVGADLALTGSTDVRLPLERDFEYAVLAMSGEAHVDGVPLVPGSMLYLGCGRDELPLRADSDAGLMLLGGEPFEEELIMFWNWIGRSQEEIVQARRDWMEGSRFGEVKGYDGAPLPAPALPAVPLKPRGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD32</accession>
    <name>Q9RD32_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0877</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625177.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977982.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0877"/>
    <dbReference type="GeneID" id="1096300"/>
    <dbReference type="KEGG" id="sco:SCO0877"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.867"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4700">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006850_4_1_11"/>
    <dbReference type="InParanoid" id="Q9RD32"/>
    <dbReference type="OMA" id="AVRETSM"/>
    <dbReference type="PhylomeDB" id="Q9RD32"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="814"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="888" mass="91964" checksum="7071FF5261B6B844" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDN7</accession>
    <name>Q9RDN7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2400</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626646.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028330.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2400"/>
    <dbReference type="GeneID" id="1097834"/>
    <dbReference type="KEGG" id="sco:SCO2400"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2441"/>
    <dbReference type="eggNOG" id="ENOG502ZQJI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080172_0_0_11"/>
    <dbReference type="OMA" id="RFLWWCT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="24810" checksum="5881E8DC253A158B" modified="2000-05-01" version="1">MDYCHPCRRHLNGALACPGCGTPCHELPASEGHLTAGEKNPPRPARDAAADAETPEEALDEGGDAGADDAAPGGRSSRRDRKAAAHRRRRRRTLLVAAGFVLAAGGLSLAELGMDAPHSPEKPAAAGGETTDGEATREVGEASAVPVGDAPAATTTTTSGTPSPGASASTTVSASASESPDAAESPTATGPDSPSASSPSSPGPTGPANPGPSSPGSDDDPPPTTTPTPPEPPDPTPTETCDRFLWWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIW9</accession>
    <name>Q9RIW9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0144</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB58307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978731.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0144"/>
    <dbReference type="GeneID" id="1095568"/>
    <dbReference type="KEGG" id="sco:SCO0144"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.122"/>
    <dbReference type="eggNOG" id="ENOG503311A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147945_1_0_11"/>
    <dbReference type="OMA" id="FWDVKNP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB58307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="12819" checksum="3F7DD6BD171E78AB" modified="2000-05-01" version="1">MALIRIEGDDLVVVIEGLDKLWAFKGSLTIPLAHVRGATVDPGIAAEPKGVRAPGSHLPGVIIAGTFHQEGEKVFWDVKDRSKAVVIELSDEQYARLVLQVDDPRATVALIEGTLAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ03</accession>
    <name>Q9RJ03_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36944">
        <property type="entry name" value="T36944"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624498.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026893.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0162"/>
    <dbReference type="GeneID" id="1095586"/>
    <dbReference type="KEGG" id="sco:SCO0162"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.135"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_2_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ03"/>
    <dbReference type="OMA" id="SHNTQCW"/>
    <dbReference type="PhylomeDB" id="Q9RJ03"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB53129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="36291" checksum="4BEA1E8CEEF2817C" modified="2000-05-01" version="1">MAQLRLDQRTVTTLVAEATTAPSMHNAQPWRFRFLAAERLVLLRADPARAMPRSDPGNRALHIGCGAALFNLRVAAVHASLVPRIRLLPDPRDPLLLASVQLADLSEAPQEKDLWRLHPAIRQRRTSRHPFSERDIPENVRATLQAAAAREGATLLFPGLWHVDTLLELVRDAESRDLVRAEEDEDLVRWTRLGGEVDTAVDGVPAYAFGPRKSDGKAPVRDFSGRRPVPDRGSAAFERTPHLALLGTRGDGPRDWLAAGQALERVLLEGTLRGLSTSLTSHPLEDRELRLLTRDPGSGVGHVQMVLRLGYGPKGPATPRRPVPDVLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ78</accession>
    <name>Q9RJ78_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1623</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625898.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977203.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1623"/>
    <dbReference type="GeneID" id="1097054"/>
    <dbReference type="KEGG" id="sco:SCO1623"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1638"/>
    <dbReference type="eggNOG" id="COG2375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040923_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RJ78"/>
    <dbReference type="OMA" id="VHAFVHG"/>
    <dbReference type="PhylomeDB" id="Q9RJ78"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015891">
        <property type="term" value="P:siderophore transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="31483" checksum="31408386C5BC0A1B" modified="2000-05-01" version="1">MADRPARKPRKPHTAQVVRTERLTPHMQRVVLGGEGLSAFAADTCTDHYVKLLFPSGGATYPEPFDMERIREDFPREQWPVTRTYTVRHWDAEHREMTLDFVIHGDEGLAGPWAKRVRPGETVHFMGPGGAYAPDPAADWHLLAGDESALPAIARSLEALPDGARAYAFVEVEGPEEEQKIDSDVEVVWLHRAGRPVGQALAEAVRALEFPEGRLHAFVHGEAACVKELRRYLRLEREIPREDLSISGYWRLGHNEDGWQASKREWNARVEAEQEGATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ82</accession>
    <name>Q9RJ82_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1619</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625894.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977207.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1619"/>
    <dbReference type="GeneID" id="1097050"/>
    <dbReference type="KEGG" id="sco:SCO1619"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1634"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_3_11"/>
    <dbReference type="InParanoid" id="Q9RJ82"/>
    <dbReference type="OMA" id="DHKEQQP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB59472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="189" mass="21054" checksum="4E27C67497BC4938" modified="2000-05-01" version="1">MGDHKDQHLRVGAAVRRRRRDLELTLAVVSERSGLSVPFLSQIENDRARPSQTSLEKVADALRTTAVELLAAADPACSVDVVRAEEPDPELAPRVRSLVRGHHQMHASEFTGDHDAGRELQYRNDQLMFVAEGAVEIEAEGRAYRLGRGDTLYLTGGVRHRWRATVPDTRLIVVAVAEHIEAVREGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJP8</accession>
    <name>Q9RJP8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0592</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624904.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027228.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0592"/>
    <dbReference type="GeneID" id="1096015"/>
    <dbReference type="KEGG" id="sco:SCO0592"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.573"/>
    <dbReference type="eggNOG" id="ENOG502ZKHT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101394_0_0_11"/>
    <dbReference type="OMA" id="WATWQRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="240" mass="24996" checksum="5BA02290B4E35B4E" modified="2000-05-01" version="1">MLLRQPTTVTEAQQCMAQGAVPVGGATLVWATWQRDGFPELAMSLRGLPEATAVEPESLGAAVVLHRIDDRVPEVLRRAAGSVGTGAVRRTATVGGNLVGSSLRCLLPAALVLDARATALGPDRPYETDLAEVMAKRHLLLGLRWRTPLASGYRKEPAEAGGPPPLVVATAVHADGEGGLRLRVAVRDGYDVLSGTTGCGTDAEETFDALGRTDIGALPAGARDVVREQVAGILGPLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJT0</accession>
    <name>Q9RJT0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0406</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624727.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027091.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0406"/>
    <dbReference type="GeneID" id="1095829"/>
    <dbReference type="KEGG" id="sco:SCO0406"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.382"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085078_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RJT0"/>
    <dbReference type="OMA" id="VEPDFFV"/>
    <dbReference type="PhylomeDB" id="Q9RJT0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="237" mass="24961" checksum="8983E6FD45631521" modified="2000-05-01" version="1">MTRSSLAAQEVVPMTMTRQDTDALGAFESLADPSASVRLRAALAVGTAPHPRFVEGLVERSAVEPEFFVRDMLTWALTRHPVAATLPPLVREVGSKLPQARSQALHTLSKIGDRRAWPAVTGAALSDADDEVARSAWRAAVVLVPEGEEQALARALAPQLGRGDRETQLSLSRALVALGESAGAVLEAAATTAPAPHVRAHALATRRLLRDPDSGFEAAIEEAKRVVALGGSGHEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJZ7</accession>
    <name>Q9RJZ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1173</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625463.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027627.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1173"/>
    <dbReference type="GeneID" id="1096596"/>
    <dbReference type="KEGG" id="sco:SCO1173"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1171"/>
    <dbReference type="eggNOG" id="COG3284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037518_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RJZ7"/>
    <dbReference type="OMA" id="HGRLLWV"/>
    <dbReference type="PhylomeDB" id="Q9RJZ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="419" mass="44668" checksum="D13D04D4D707F700" modified="2000-05-01" version="1">MTDAWLALEPGADPVERARALRRAHETFTEAGTVRRPVRAVVADSWRRSVRAGVGPDGTASVELMDGDLGAYRAEHPLSRVMPLVRELLGTFAADGEHLLAVCDAHGRLLWVEGHPATRRRAGRMNFVPGARWSESAVGTNAPGTAVAVGRPVQVFAAEHFIRRVQPWTCAAAPVHDPRTGRVLGAVDITGGDGLAHPHSLGFVQAVARAAESQLALLTPERSASEAAELTALGRDEALLSADGRRVRLSRRHSEIVVLLAHHPEGLTGDELLCALYEDETVPPVTLRAELARLRGILGPGRLASRPYRLTMPVESDTSVVERRLRAGAVTAAAAAYAGPLLPGSQAPAVGRLRRRLADGLRAALIACGDPDLLADWAHAPWGEDDLDVWRALAAVRPTAATSSRLAALESELAAPNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK58</accession>
    <name>Q9RK58_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO0552</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB59609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624866.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027198.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0552"/>
    <dbReference type="GeneID" id="1095975"/>
    <dbReference type="KEGG" id="sco:SCO0552"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.533"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_11"/>
    <dbReference type="InParanoid" id="Q9RK58"/>
    <dbReference type="OMA" id="LWIDLIS"/>
    <dbReference type="PhylomeDB" id="Q9RK58"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB59609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="26178" checksum="6CF68BF514BFCEF7" modified="2000-05-01" version="1">MTDRLTCLPMASVLVVEDDPVIRAALIEVLTGHGYAVKTAHQGFEALRDITQSPPDIVVLDLGLPDLDGLDVLRMIRGISRVPVLVATARDDETEIIRLLNAGADDYMVKPFSGGQLAARLAAVLRRSAPAGLRAARPPVLRVADLRIDPTARTAHLAGRELPLTRREFDLLAYLAAHADQVMSRQRILAEVWQQPYVEDQTVDVHLSALRRKMGEKARKPRYLHTVRGIGIKLVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKK0</accession>
    <name>Q9RKK0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4084</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628265.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029422.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4084"/>
    <dbReference type="GeneID" id="1099521"/>
    <dbReference type="KEGG" id="sco:SCO4084"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4143"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071263_0_0_11"/>
    <dbReference type="OMA" id="LDWPFAI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB56364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="202" mass="21565" checksum="DFFEE60A13C91964" modified="2000-05-01" version="1">MDRLLGEPEPVRQDGRLLDWPFAIAADADAIAGTARRLAAEHSDLDAHLAEVERRFTERLDTHPGSRLLPTSAGALPLADYVVTRTVELVVHTDDLNAAVPGLDIPYDRQALAAATRLLADALAVKAPGGSTEVRVPPYAVVQCVEGPRHTRGTPPNVVETDPLTWIRLATGRLAWKDALDGAKVSASGERADLGPLLPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ7</accession>
    <name>Q9RKQ7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2271</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50580">
        <property type="entry name" value="T50580"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626519.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028240.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2271"/>
    <dbReference type="GeneID" id="1097704"/>
    <dbReference type="KEGG" id="sco:SCO2271"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2308"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570969_0_0_11"/>
    <dbReference type="OMA" id="DWGIKSS"/>
    <dbReference type="PhylomeDB" id="Q9RKQ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176944" evidence="3">
        <location>
            <begin position="29"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="HtaA" evidence="4">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HtaA" evidence="4">
        <location>
            <begin position="238"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="477" mass="48242" checksum="A0B9022127689F5C" modified="2000-05-01" version="1">MPARLRALVTVLCAAVLAALLPAAAAHAENRTVQGGRLDWGIKSSFQTYVTGPVAKGGYSLNGGAATVGGSSFRFHSATGTYDGDTGAFHVAFSGGVHFLGHRTSTGAHQLDLTLSRPTVSISGSTGTLHLDVVSRAKDTGAVTTSRQVPFASLSLGGIDMRGGGGTVALDNLPATLTAEGARSFAGYYTAGTALDPVSLSADVKAPAPKRQTRPADTPAPSAESPKPAQTPGGTLQDGAVDWGVRRTFREYVTGDIAHGEWALTAGAQDGGALFRFPGGEGTYEDGDLNAAFRGTVRFTGAHGLDLSLGNVRTVVEDGRGTLYADVTSPDVKEAKVPLVTFTAGEPKPAGGLVKVTEAPAKLTARGAKAFGGMYRAGTEMDPVSLAVALTADAELPALPDLGSEPAPSASPRPEQTGADPSAAPAAATTDAGDFPALPVSLAAGALLLAAAALVTVAQRRRNRARPAASPADPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKY8</accession>
    <name>Q9RKY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1430</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB61661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625712.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977395.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1430"/>
    <dbReference type="GeneID" id="1096856"/>
    <dbReference type="KEGG" id="sco:SCO1430"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1440"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_11_0_11"/>
    <dbReference type="InParanoid" id="Q9RKY8"/>
    <dbReference type="OMA" id="YYFQSKR"/>
    <dbReference type="PhylomeDB" id="Q9RKY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB61661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="24128" checksum="42AD6C05C8FB9A48" modified="2000-05-01" version="1">MNISQQPADVRPRARGTERSVARRAELIAIGRRLFADTSYDALSMDDIARQAHVAKGLIYYYFQSKRGYYLAIIQDSVAGLVTTAARGTELPQVDRVHRTIDGYLRYAEHNQAAYRTIVSGGVGFDAEVHGIRDGVREAIVATIAEGAYGRSDIGPLARMGLLAWVCSVEGATLDWIGRPELPRETMRELLVKSLGGTLRAIEELDPGYPAPAPARRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKZ7</accession>
    <name>Q9RKZ7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0321</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624648.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027016.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0321"/>
    <dbReference type="ESTHER" id="strco-cxest2">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="GeneID" id="1095745"/>
    <dbReference type="KEGG" id="sco:SCO0321"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.295"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_4_11"/>
    <dbReference type="InParanoid" id="Q9RKZ7"/>
    <dbReference type="OMA" id="DLLVCHT"/>
    <dbReference type="PhylomeDB" id="Q9RKZ7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB55678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="518" mass="54527" checksum="B50EE40BFD534010" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1T2</accession>
    <name>Q9S1T2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0060</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37124">
        <property type="entry name" value="T37124"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624414.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026816.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0060"/>
    <dbReference type="GeneID" id="1095491"/>
    <dbReference type="KEGG" id="sco:SCO0060"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.50"/>
    <dbReference type="HOGENOM" id="CLU_3205613_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB52975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="45" mass="4518" checksum="F20829E3EFB1B04C" modified="2000-05-01" version="1">MALIVGGELRVAVTERAALTELPALHSRAAEGAVHGKVVVVPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S1T3</accession>
    <name>Q9S1T3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0059</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37123">
        <property type="entry name" value="T37123"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624413.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026815.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0059"/>
    <dbReference type="GeneID" id="1095490"/>
    <dbReference type="KEGG" id="sco:SCO0059"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.49"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="InParanoid" id="Q9S1T3"/>
    <dbReference type="OMA" id="FHEYGAP"/>
    <dbReference type="PhylomeDB" id="Q9S1T3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="268" mass="27164" checksum="C73710CC9E40D6F9" modified="2000-05-01" version="1">MKAVRFHEYGAPDVLRYEDVEQPLPGAGEVRVRVAATSFNSVDGNIRGGFMRGPIPVVLPHTPGIDVAGTVDALGEGVDGVAVGDDAIGFLTMDGDGAAAEYVLAPAEALAPAPRSVPLADVAAVPVVGLTAYQTLFNRGRLTAGQRVLINGAGGTVGGYAVQLAKDAGAHVIATSSPRSREAVASAGDDEIIDHTTTDVTAAVTEPVDIALSLAPVAPAELAALVTLVRPGGVVVNTTVWMPAPATRSAAYGASTCSSAATSTSWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S223</accession>
    <name>Q9S223_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1777</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36880">
        <property type="entry name" value="T36880"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626048.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027969.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1777"/>
    <dbReference type="CAZy" id="GH15">
        <property type="family name" value="Glycoside Hydrolase Family 15"/>
    </dbReference>
    <dbReference type="DNASU" id="1097208"/>
    <dbReference type="GeneID" id="1097208"/>
    <dbReference type="KEGG" id="sco:SCO1777"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1795"/>
    <dbReference type="eggNOG" id="COG3387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010399_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S223"/>
    <dbReference type="OMA" id="RMRFSYG"/>
    <dbReference type="PhylomeDB" id="Q9S223"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015927">
        <property type="term" value="F:trehalase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="232"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="612" mass="68440" checksum="2DCCFFFC195476BD" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2B4</accession>
    <name>Q9S2B4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative gntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1716</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36738">
        <property type="entry name" value="T36738"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625989.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977110.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1716"/>
    <dbReference type="GeneID" id="1097147"/>
    <dbReference type="KEGG" id="sco:SCO1716"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1733"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_3_1_11"/>
    <dbReference type="OMA" id="RGTFIEP"/>
    <dbReference type="PhylomeDB" id="Q9S2B4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="249" mass="28008" checksum="6B3B5C442753A4A4" modified="2000-05-01" version="1">MTSFAPDSIVLNRKLPLWYQVSQSLRASILGRSPRDPLRLPTEEQLAGHYGVSVLTMRQALKELEDEGLITRHRRRGTFIEPHARRGAPVRLLGSVDAIVAQQSGMKAELLDHGTAPVPSELAEYFPQVPEVALYHRLRCDEKTGEPTNHARNYVRPELAGRIDLDDLARWPMTKVLRDVVGMDISRITDTVEARLADPETARLLEVPLLSPILHYTGITYDLEGRVLDVAVIHYRGDRFSFTVTLDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2E2</accession>
    <name>Q9S2E2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0258</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36398">
        <property type="entry name" value="T36398"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624589.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026967.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0258"/>
    <dbReference type="GeneID" id="1095682"/>
    <dbReference type="KEGG" id="sco:SCO0258"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.231"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070077_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2E2"/>
    <dbReference type="OMA" id="CSPAFAW"/>
    <dbReference type="PhylomeDB" id="Q9S2E2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="269" mass="28957" checksum="0EF7C813870BFF83" modified="2000-05-01" version="1">MWAAQLEVAARAALDTVYDPELDEPVTDLGFVRSLTAEDGRVTVHLRLPTSFCSPNFAYLMASDAKDALSALPGAREVTVLLDDHHDSDLINRGLAADAGYRGTFGHEAEQDLEELRGIFRRKAHTAAMERALTALLRARPDLAEEQLGDVVLGDLPDTSATRALLRRRAALGLGTAPADPALVDDDGRPCPRGEVPLRLRFARSVRISIDGNAHFCRGLLRTRYPQSAADQSARPEEFPAGGEPVGAGETVPAGELFRLSAPAKENVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-27" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U1</accession>
    <name>HIS3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="1">PRA-CH</shortName>
            <ecNumber evidence="1">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisI</name>
        <name type="ordered locus">SCO2044</name>
        <name type="ORF">SC4G6.13c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35073">
        <property type="entry name" value="T35073"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976772.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2U1"/>
    <dbReference type="SMR" id="Q9S2U1"/>
    <dbReference type="STRING" id="100226.SCO2044"/>
    <dbReference type="GeneID" id="1097478"/>
    <dbReference type="KEGG" id="sco:SCO2044"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2075"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_1_11"/>
    <dbReference type="InParanoid" id="Q9S2U1"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="PhylomeDB" id="Q9S2U1"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000136501" description="Phosphoribosyl-AMP cyclohydrolase">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <sequence length="128" mass="13834" checksum="3161011CC2990A82" modified="2000-05-01" version="1">MTSSSPTGGGPGRPSALAPEIADRLKRSADGLLPAIAQQYDTGEVLMLGWMDDEALHRTLTTGRCTYWSRSRGEYWVKGDTSGHFQWVKSVALDCDADTVLVKVDQVGAACHTGTRTCFDTDVLLADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2U7</accession>
    <name>Q9S2U7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2035</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35064">
        <property type="entry name" value="T35064"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626295.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976781.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2035"/>
    <dbReference type="GeneID" id="1097469"/>
    <dbReference type="KEGG" id="sco:SCO2035"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2066"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_3_11"/>
    <dbReference type="InParanoid" id="Q9S2U7"/>
    <dbReference type="OMA" id="HNDSSTR"/>
    <dbReference type="PhylomeDB" id="Q9S2U7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="102"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="29424" checksum="B46AF89DCA186591" modified="2000-05-01" version="1">MDLGPGRRAAPPRFVLRGVSEKNRQGKRGAREKLAAEREKQRSRDKRRRALIVGASVVCVLGLAAVIGVVAANAGKDDGSESAGPVVAPSGAQGKDGLAIPVGEESAKSTLTVWEDFRCPACKAFELAYRNTIHELTDAGQLKVEYHLATIIDGNMGGTGSRKAANAAACAQDAGKFPPYHDVLYDNQPPETDDAFADENKLLDLAGKVDGLDTTLFQECVKNGKHNSWVEKSNKAFQNGGFSGTPTVLLDGKNIYQDRSMTPAKLKQMVEDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7M7</accession>
    <name>Q9X7M7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6721</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35246">
        <property type="entry name" value="T35246"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630794.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031133.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6721"/>
    <dbReference type="GeneID" id="1102160"/>
    <dbReference type="KEGG" id="sco:SCO6721"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6828"/>
    <dbReference type="eggNOG" id="ENOG5032X58">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080168_0_0_11"/>
    <dbReference type="OMA" id="HRYPVAD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB40671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="302" mass="32482" checksum="E726166C67F78A0A" modified="1999-11-01" version="1">MTAVGRGESTKEALLRQRLGRLERRGRTRRTHVGYVGRGVSGPQTSNVLLQSAATEAMSNLDTTRLACQRIYAEPEEAPVPNGSLSLPARLCLLAWDPERSSAAETARVHHLVRAGALTELAQRGLLTDDEGIATPADLDSRTGDAVLDGLLELVRESLPHRWRTWVRLHARVTFDAVREQLVAEGYLRAEKKRVLGVFPSVEYVLARGAAARALREEARRVLRGPQPAGEVSERDAALAALAAAAGLGVPEGTVTGVRAQDRITELARRCASAAPGMRKVVSEVWDAVSDEGARAPASARG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7N2</accession>
    <name>NFI_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name type="ordered locus">SCO6726</name>
        <name type="ORF">SC5F2A.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35251">
        <property type="entry name" value="T35251"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630799.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031135.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X7N2"/>
    <dbReference type="SMR" id="Q9X7N2"/>
    <dbReference type="STRING" id="100226.SCO6726"/>
    <dbReference type="GeneID" id="1102165"/>
    <dbReference type="KEGG" id="sco:SCO6726"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6833"/>
    <dbReference type="eggNOG" id="COG1515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_11"/>
    <dbReference type="InParanoid" id="Q9X7N2"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="PhylomeDB" id="Q9X7N2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000159673" description="Endonuclease V">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <sequence length="233" mass="24313" checksum="F3E8E6F7B5BDCED6" modified="1999-11-01" version="1">MTTVSVQIPAGWPATEERARAVQDELRARVVLDEPGPPPGTGRVTGVDVAYDDERDVVAAAAVVLDAGTLAVVAEATAVGRISFPYVPGLLAFREIPTVLAALEALPCPPGLVVCDGYGLAHPRRFGLASHLGVLTGLPTIGVAKNPFTFTHDDPDTPRGSTSPLLAGAEEVGRAVRTRDGVKPVFVSVGHRVGLGNACAHTLALTPAYRLPETTRRADALCRAALRDAAYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7R2</accession>
    <name>Q9X7R2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7288</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35320">
        <property type="entry name" value="T35320"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631344.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971855.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1102726"/>
    <dbReference type="KEGG" id="sco:SCO7288"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7390"/>
    <dbReference type="eggNOG" id="ENOG5030G98">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087620_0_1_11"/>
    <dbReference type="OMA" id="WYLLCWF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="18830" checksum="AA4596CF01893863" modified="1999-11-01" version="1">MRDAEAAEGSGRRRGRNETEEERADRMWTELIQEVRVAQMGVQILFGFLLTVVFQPKYDTLSDTDQMIYLITVVLGAVTTGALIGPVSLHRLVSGRRVKPQAVRWASRLTVLGLVLLLATTACSLLLILRVATHDGFVPYLVTGVVLWYLLCWFGIPLWTRHRHTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X849</accession>
    <name>Q9X849_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TmrB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3388</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB40928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36076">
        <property type="entry name" value="T36076"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627595.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975445.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3388"/>
    <dbReference type="GeneID" id="1098825"/>
    <dbReference type="KEGG" id="sco:SCO3388"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3451"/>
    <dbReference type="eggNOG" id="COG3265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111135_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X849"/>
    <dbReference type="OMA" id="MLLWING"/>
    <dbReference type="PhylomeDB" id="Q9X849"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB40928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="24033" checksum="CEDDCF541843FDD1" modified="1999-11-01" version="1">MDQRPLRGRQSIQSLPAHEIRRRLPGSVVCDPEHAGFGLRRMLPPELREDFQDLVSWRQGVVEVLDLALTRHDGVVIAPMTVTDPGYFAETVGRLRELGHDVHHFSLLAARETVLRRLRERGPGHALRYVTGKAGQGSGPRRESWAVRQLDHCLERLAEPEFAEHLWTDHTTVPKTADRIAVLAGLTLKPNNEGALRTRMRQAGVGIRHIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8J8</accession>
    <name>Q9X8J8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3419</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36345">
        <property type="entry name" value="T36345"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627625.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028964.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3419"/>
    <dbReference type="GeneID" id="1098856"/>
    <dbReference type="KEGG" id="sco:SCO3419"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3482"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_4_1_11"/>
    <dbReference type="InParanoid" id="Q9X8J8"/>
    <dbReference type="OMA" id="WGAHEWS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="213" mass="23643" checksum="14EF82CA0C31C61A" modified="1999-11-01" version="1">MSAIRLLVLGAVRQHGRAHGYQVRNDLEYWGAHEWSNAKPGSIYHALKQMAKQGLLLAHEIAPSTAGGPPRVEYEITGQGTEEYLSLLRAYLTAYDQRPDVLTAALGFMVDLPREEALALLKERVRKIEEWRASVTEYYMPAEGPGQYGHIGEIMNYWVHSADSGAEWTRGLIERVRGGAYTFAGEGEPFVGVLAEGEENPFAAGRPHYGDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8K5</accession>
    <name>Q9X8K5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3426</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36352">
        <property type="entry name" value="T36352"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627632.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028970.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3426"/>
    <dbReference type="GeneID" id="1098863"/>
    <dbReference type="KEGG" id="sco:SCO3426"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3488"/>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017452_2_2_11"/>
    <dbReference type="InParanoid" id="Q9X8K5"/>
    <dbReference type="OMA" id="WHPEHGD"/>
    <dbReference type="PhylomeDB" id="Q9X8K5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="254"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="370" mass="38533" checksum="9CE7677A98D48AF0" modified="1999-11-01" version="1">MSEPGRFHEPPVVIVGGLHADARRAAVARLLADVPGSVVLHHDLATAAAGTVVRTVRDATGILAAGEAPLVNDCACCALREDLVPELVRLAEAGGTPLAVVELWDSVEPKAMAEVVTAGGFTVAGVVTAVDPALVLPYLGNGDDLAEGGLAAAATDQRTVADTFARQLEYASVLALAEPLPGSPEADDEDRELLAQLHPTARRVPIGHGNPAGTPPAGPELARAALAGFDVEAAAAAQHPACALLPAEADAHGVATLVWHRRRPFHPERLYAALEDLTCAAARSRGRFWLAGKGDTLLHWDAAGGALCVESAGPWLASLPDAAWELVPPVRRAAAALDWHPEHGDRCQHLVFTSPGLDRDGLERLLESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Z1</accession>
    <name>Q9X9Z1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1801</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB45293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36862">
        <property type="entry name" value="T36862"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626071.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027984.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1801"/>
    <dbReference type="GeneID" id="1097235"/>
    <dbReference type="KEGG" id="sco:SCO1801"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1822"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9X9Z1"/>
    <dbReference type="OMA" id="DHQVVRR"/>
    <dbReference type="PhylomeDB" id="Q9X9Z1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB45293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="22679" checksum="3D3222C0455AB9E8" modified="1999-11-01" version="1">MIKVLLVDDHQVVRRGLRTFLEVQDDIEVVGEAADGAEGVDRAQELKPDVILMDVKMPGMDGVDALRRLRELDNHARVLVVTSFTEQRTVVPALRAGAAGYVYKDVDPDALAGAIRSVHAGHILLQPEVAGALLSQEESSSGPGRAGSLTEREREVLGLIADGRSNREIARALVLSEKTVKTHVSNILMKLDLADRTQAALWAVRHGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XA25</accession>
    <name>Q9XA25_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3839</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36708">
        <property type="entry name" value="T36708"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628027.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975095.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3839"/>
    <dbReference type="GeneID" id="1099275"/>
    <dbReference type="KEGG" id="sco:SCO3839"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3909"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_13_0_11"/>
    <dbReference type="InParanoid" id="Q9XA25"/>
    <dbReference type="OMA" id="ICHHGAR"/>
    <dbReference type="PhylomeDB" id="Q9XA25"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="109" mass="11548" checksum="A8C69B9F05349B1F" modified="1999-11-01" version="1">MPTVGIEDLADGDFLLDVREDDEWQAGHAAGALHIPLSEFVARYGELAEAAPQDARVHVLCRVGGRSAQVTMYLVQQGVDAVNVDGGMQEWAAAGRPVVDDKGAPGHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC3</accession>
    <name>Q9XAC3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1933</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36005">
        <property type="entry name" value="T36005"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626198.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028052.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1933"/>
    <dbReference type="GeneID" id="1097367"/>
    <dbReference type="KEGG" id="sco:SCO1933"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1959"/>
    <dbReference type="eggNOG" id="ENOG5033IPK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150079_0_0_11"/>
    <dbReference type="OMA" id="VAPTHEI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB50758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="15311" checksum="39D2983A67A4616A" modified="1999-11-01" version="1">MRGQGHAPRPSPFDLPVGSILLMADTQQVDTEQSGAKGGWAGRWDAYEVTRTAGRIEAFAKAHGGAEAQVAHLGERGARIVLVGADGAWGDLVARTHERARKAVEKSGITVHEDFDGEFAAKVTTGRYEWSRMAGIQVGGPSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAC8</accession>
    <name>Q9XAC8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter, ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1928</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36000">
        <property type="entry name" value="T36000"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626193.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976891.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1928"/>
    <dbReference type="GeneID" id="1097362"/>
    <dbReference type="KEGG" id="sco:SCO1928"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1954"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_11"/>
    <dbReference type="InParanoid" id="Q9XAC8"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="PhylomeDB" id="Q9XAC8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB50753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="307" mass="32963" checksum="F071825B125BAD8A" modified="1999-11-01" version="1">MRSEPVVQVQALVKRYGTKTAVNGLDLVARTGVTAVLGPNGAGKTTTVETCEGYRRPDSGTVRVLGLDPVRQGAELRPRIGVMLQSGGVYSGARADEMLRHVAKLHAHPLDVDALIERLGLDSCGRTTYRRLSGGQQQRLALAMAVVGRPELVFLDEPTAGLDPQARRATWDLVRDLRGDGVSVILTTHHMDEAEQLADDVAIIDTGRVVAQGSPEELCRGGAENTLRFTGRPGLDVASLLKALPPDSAAAELTPGSYRVNGEVDPQLLATVTSWCAQHGVMPDRISVERHTLEDVFLELTGKELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAF0</accession>
    <name>Q9XAF0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5301</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35628">
        <property type="entry name" value="T35628"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629443.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973670.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5301"/>
    <dbReference type="GeneID" id="1100741"/>
    <dbReference type="KEGG" id="sco:SCO5301"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5387"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_0_11"/>
    <dbReference type="InParanoid" id="Q9XAF0"/>
    <dbReference type="OMA" id="TPYAWFI"/>
    <dbReference type="PhylomeDB" id="Q9XAF0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177042" evidence="1">
        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="485" mass="50269" checksum="4CA101FDE2F89980" modified="1999-11-01" version="1">MTRNIRHAAVFCALLLVALVVNAARVQIVQKPEYDDNPANRRPDIARYQQPRGDILVGGGAVTGSRDTGEHLRFERTYADGPMYAPITGFASQAYGTTLLEHAEDGLLSGADPMLAPLPLWNDVTGAHNPGGDVVTTIHGAAQRAAFEGLGGRKGAVAAIEPATGRVLALVSTPSYDPQLLSGNSAAATRTWKRLNADPDKPMLNRAVSRTYPPGSTFKVVTAAAALEAGVIRDLDAPTRSPDPYTLPGTRTKLTNEADGCRNASLREAFEWSCNTVFAKLGVDVGVRGMTAMAEAFGFNDDGLRVPFPVARSTFDTSVDRAQLGLSSIGQYNTRATPLQMATVAAAVAGGGQVRSPYLVERTLRAGGSLVAAAGSRPSREVMRPSTAALLKELMTGVVDKGTGAKAAIPGATVGGKTGTAQHGVGNSGTPYAWFISWARGAGDIEPKVAVAVVVEGTASDRQGVSGGGLAAPIARAVMEAVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI5</accession>
    <name>Q9XAI5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3617</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35385">
        <property type="entry name" value="T35385"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627812.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975322.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3617"/>
    <dbReference type="GeneID" id="1099053"/>
    <dbReference type="KEGG" id="sco:SCO3617"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3675"/>
    <dbReference type="eggNOG" id="ENOG502ZWN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106307_0_0_11"/>
    <dbReference type="OMA" id="WWQFSYF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="219" mass="24335" checksum="DD19207754ADC1E3" modified="1999-11-01" version="1">MSDATLHATDQNPDDFAVQIADQIESFLVAVTEVAKGDEPDSAVPFLLLEVSQLMLAGGRLGAHEDIVPDERYEPDPGPELDVDEIRENLARILDPVDVYSEVFDPYEPRKAPVPARISDDLTDVITDLRHGMVHYKAGRTTEALWWWQFSYFSNWGSTASATLRALQSVVAHVRLNQPLEELDGLDTDQELGEETLESEAGRVMVREIAAPLGLRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAM7</accession>
    <name>Q9XAM7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 3-oxoadipate CoA-transferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6703</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAB45577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35021">
        <property type="entry name" value="T35021"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630776.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031119.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6703"/>
    <dbReference type="GeneID" id="1102142"/>
    <dbReference type="KEGG" id="sco:SCO6703"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6810"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_11"/>
    <dbReference type="InParanoid" id="Q9XAM7"/>
    <dbReference type="OMA" id="FVKAWKG"/>
    <dbReference type="PhylomeDB" id="Q9XAM7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB45577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="260" mass="26784" checksum="EBB2E3A8843DA169" modified="1999-11-01" version="1">MDKVVATAGAAVADVADGASLAVGGFGLSGVPNVLIQALYERGTGGLSVVSNNCGAMESGLAVLLAAGRIARVTGSYIGANKEFARQYLGGELEVEMIPQGTLAERLRAGGAGIPAFYTPAGVGTQVADGGLPWRYDGSGGVALASPPKEVREFDGTQYVLERGIRTDFALVRAAKGDRHGNLVFAKSSRNFNPLAATAGRVTIAEVEELVEPGAIDPDAVHLPGIFVQRVVALTPEQATDKKIERRTISAPPARGTVTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAQ5</accession>
    <name>NUOB1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B 1</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB1</name>
        <name type="ordered locus">SCO4563</name>
        <name type="ORF">SCD16A.20c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB44530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34623">
        <property type="entry name" value="T34623"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628725.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006133126.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9XAQ5"/>
    <dbReference type="SMR" id="Q9XAQ5"/>
    <dbReference type="STRING" id="100226.SCO4563"/>
    <dbReference type="GeneID" id="1100003"/>
    <dbReference type="KEGG" id="sco:SCO4563"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4635"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_11"/>
    <dbReference type="InParanoid" id="Q9XAQ5"/>
    <dbReference type="OMA" id="AGWVRKS"/>
    <dbReference type="PhylomeDB" id="Q9XAQ5"/>
    <dbReference type="PRO" id="PR:Q9XAQ5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000376387" description="NADH-quinone oxidoreductase subunit B 1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <sequence length="184" mass="20017" checksum="7D887DBD851C5469" modified="1999-11-01" version="1">MGLEEKLPSGFLLTTVEQAAGWVRKSSVFPATFGLACCAIEMMTTGAGRYDLARFGMEVFRGSPRQADLMIVAGRVSQKMAPVLRQVYDQMPNPKWVISMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLMDAILKLHQKIQSSKLGVNAEEAAREAEEAALKALPTIEMKGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z556</accession>
    <name>Q9Z556_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6116</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA22783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35899">
        <property type="entry name" value="T35899"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630222.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030661.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6116"/>
    <dbReference type="GeneID" id="1101557"/>
    <dbReference type="KEGG" id="sco:SCO6116"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6219"/>
    <dbReference type="eggNOG" id="COG5476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028172_2_0_11"/>
    <dbReference type="InParanoid" id="Q9Z556"/>
    <dbReference type="OMA" id="FKEFPHT"/>
    <dbReference type="PhylomeDB" id="Q9Z556"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1485" evidence="2">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="MlrC_C" evidence="1">
        <location>
            <begin position="309"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="513" mass="55118" checksum="68C76272CF14CAB3" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBH2</accession>
    <name>Q9ZBH2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6441</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA22750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35928">
        <property type="entry name" value="T35928"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630526.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030921.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6441"/>
    <dbReference type="GeneID" id="1101880"/>
    <dbReference type="KEGG" id="sco:SCO6441"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6541"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBH2"/>
    <dbReference type="OMA" id="GIRSAAC"/>
    <dbReference type="PhylomeDB" id="Q9ZBH2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="15"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA22750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="468" mass="48948" checksum="490D0F30E6C8A4BD" modified="1999-05-01" version="1">MAPATGRPPHTTDRGGYFAVVDPSTGEAFDEAPDRRPEELDPVVDRARAAWPGWRADPAARRTALLAAADAVEAAATALAPLLTREQGKPLTESHAEVARTAARLRYFAELDIGAQPITDDRPVHSRLRWRSIGAVAAIVPWNFPLQLASAKFAPALAAGNTMVLKPSPSTPLATRMLGAVLAGSLPEGVLTVVTGREPLGARLASHPGIRHVTFTGSAATGRAVAAGAAASLARVTLELGGNDAAILLDDVDVEEIADRLFWAAFRNCGQVCMAVKRVYAPARLHDRVVEALAHRASTTVVGPGLDPASRIGPVSNAPQLAHVERRTARALADGGRAAAGGHRLDRPGYFFAPTILADVPAGSPVVTEEQFGPVLPVLPYDSLDEAVRAANDTGFGLGGSVWSTDLDRAAAVADRLECGTAWINHHAELSLAQPFAGAKDSGVGVAGGPWGLYGNLRPFVVHRPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBR2</accession>
    <name>Q9ZBR2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5567</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35651">
        <property type="entry name" value="T35651"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629702.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030310.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5567"/>
    <dbReference type="GeneID" id="1101008"/>
    <dbReference type="KEGG" id="sco:SCO5567"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5656"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_1_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBR2"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="PhylomeDB" id="Q9ZBR2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="20961" checksum="B9DD7DED1954D9A0" modified="1999-05-01" version="1">MTRVIAGKAGGRRLAVPPGTGTRPTSDRAREGLFSTWQSLLGGPLDGERVLDLYAGSGAVGLEALSRGAGHVLLVEADARAARTVRANVDSLGLPGAEVRAGRAEQIIRTPAPAEPYDVVFLDPPYAVSDDDLREILLTLRTEGWLGTEALVTVERSTRGGEFRWPHGFEAIRARRYGEGTFWYGRAASTCEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-04-07" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBY7</accession>
    <name>Q9ZBY7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cytochrome oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">SCO3945</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36051">
        <property type="entry name" value="T36051"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974998.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3945"/>
    <dbReference type="GeneID" id="1099381"/>
    <dbReference type="KEGG" id="sco:SCO3945"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4017"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_11"/>
    <dbReference type="InParanoid" id="Q9ZBY7"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="PhylomeDB" id="Q9ZBY7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016682">
        <property type="term" value="F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAA22217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="501" mass="55887" checksum="C41FB99C63A0FCB2" modified="1999-05-01" version="1">MDLALAPETLARWQFGITTVYHFLFVPLTISLAALTAGLQTAWVRTEKEKYLRATKFWGKLFLINIAMGVVTGIVQEFQFGMNWSDYSRFVGDVFGAPLAFEALIAFFFESTFIGLWIFGWDKLPKKIHLACIWMVSIGTLLSAYFILAANSWMQHPVGYRINEEKGRAELTDFWQVLTQNTTLNQVFHSFSAAFLTGGAFMVGIAAFHLMRKKHIPVMRTSLRLGLVTLAVGGLLTAVSGDTLGKVMYEQQPMKMAAAEALWDGEKPAPFSVFAYGDVDKGHNKVALEVPGLLSFLAHSDFESYVPGINDTNKALQEQFGPGDYKPIVPVAYWGFRWMIGFGMASFSLGLLGLWLTRKRFLLPPALRTGEDEVPHLVLLKKPLGARLTRMYWLLALWTMAFPLIANSWGWIFTEMGRQPWVVYGVMQTRDAVSPGVSTAEVIISMSVFTLLYAVLAVIEVKLLAKYVKAGPPELTEADLNPPTKIGGDLRDADKPMAFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBZ1</accession>
    <name>Q9ZBZ1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3939</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAA22211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36045">
        <property type="entry name" value="T36045"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628123.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029326.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3939"/>
    <dbReference type="GeneID" id="1099375"/>
    <dbReference type="KEGG" id="sco:SCO3939"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4012"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030559_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBZ1"/>
    <dbReference type="OMA" id="VDNVGFF"/>
    <dbReference type="PhylomeDB" id="Q9ZBZ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="268"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA22211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="482" mass="50976" checksum="4633659E93B9FD62" modified="1999-05-01" version="1">MTATSLSKGANVAVDSPAVRAELVWSPGPGVPEVDASALLLTSAGRVRDDGDFVFYNQPRHTSGAVGHLGKRVGPGANAGLTTDAVEVDLRAVEAAVERIVLCASADGGTFGRVPGLSLRLLDAATGTELARFDITADTETALVGGELYRRAGTWKFRAVGQGYASGLAGLATDFGITVDDDAPPTAPATPATAPPTAPPVPAPPTTAVPPPPPALASPPVPAPAATGPRLTKGEERLPVDMRKRLSLRKEQVAVSLSKHGAAGITARVVLVLDASGSMSFLYSKGVVADVVERMAAVAAQLDDDGEMQAWTFASNPARLPDLPLGDLPKWLRLHVRVGEISLFRRGRKKGLHPEQVDMRAVGIQNEEQKVIAEVRAFVRANPAPVPTLVLFFSDGGVYRNAEIERELREAVEEPVFWQFVGLGRSNYGVLERFDTLPGRRVDNVGFFAVDDIGTVPDPELYDRLLSEFPSWVTAAGRAGIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O50488</accession>
    <name>RECX_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">recX</name>
        <name type="ordered locus">SCO5770</name>
        <name type="ORF">SC4H8.09</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35140">
        <property type="entry name" value="T35140"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629895.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030443.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O50488"/>
    <dbReference type="SMR" id="O50488"/>
    <dbReference type="STRING" id="100226.SCO5770"/>
    <dbReference type="GeneID" id="1101212"/>
    <dbReference type="KEGG" id="sco:SCO5770"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5859"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_0_2_11"/>
    <dbReference type="InParanoid" id="O50488"/>
    <dbReference type="OMA" id="WVHSRHT"/>
    <dbReference type="PhylomeDB" id="O50488"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000162479" description="Regulatory protein RecX">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="188" mass="20922" checksum="3A80A4243DC8344C" modified="1998-06-01" version="1">MEPSAEDGGATSSSRAEKGEPPRDPVEQARAICLRLLTGTPRTRRQLAEALRKREIPEEAAEEVLSRFEEVGLINDGAFAQAWVESRHHGRGLARRALARELRTKGVEAALIDVAVSQLDTEQEEETARDLVARKLRATRGLDRDKRLRRLAGMLARKGYSEGMALRVVRQALEEEGEDTEHLGDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O54153</accession>
    <name>O54153_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5890</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34916">
        <property type="entry name" value="T34916"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630011.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030515.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5890"/>
    <dbReference type="GeneID" id="1101332"/>
    <dbReference type="KEGG" id="sco:SCO5890"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5989"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_8_0_11"/>
    <dbReference type="InParanoid" id="O54153"/>
    <dbReference type="OMA" id="HLNNRAM"/>
    <dbReference type="PhylomeDB" id="O54153"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="110"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="640" mass="68062" checksum="E619FBB5E55A613F" modified="1998-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O69819</accession>
    <name>O69819_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6425</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28695">
        <property type="entry name" value="T28695"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630511.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972553.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6425"/>
    <dbReference type="GeneID" id="1101864"/>
    <dbReference type="KEGG" id="sco:SCO6425"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6525"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_87_2_11"/>
    <dbReference type="InParanoid" id="O69819"/>
    <dbReference type="OMA" id="HQHDCAQ"/>
    <dbReference type="PhylomeDB" id="O69819"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="159"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA18912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="256" mass="27762" checksum="1971B47CBEB684C4" modified="1998-08-01" version="1">MRVTRELPALAAGEVDVSFVIKAYAEVVAADTTWTEHSHPWHELLWNAHGASTAVTGSQVWCVTPTLGLWMPAGQLHSASAVAGTSYRAHFFRHGTVSALPDEPVAVDITPLLRLLLDRLGEPDLPPRSRDVTEAMVLDVLRPSPRALLVHLPTSALLRPIVDAVRADPSDQRTLTGWATVLGCSERTLTRAFRTETGTSFARWVASVRAQHAVRLLARGFEVEVVADAVGYRSASAFGAAFRRTTGTTPGRFRAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O69833</accession>
    <name>Y6045_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>UPF0276 protein SCO6045</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO6045</name>
        <name type="ORF">SC1B5.05c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the UPF0276 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA18979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34683">
        <property type="entry name" value="T34683"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630155.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030615.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O69833"/>
    <dbReference type="SMR" id="O69833"/>
    <dbReference type="STRING" id="100226.SCO6045"/>
    <dbReference type="GeneID" id="1101486"/>
    <dbReference type="KEGG" id="sco:SCO6045"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6146"/>
    <dbReference type="eggNOG" id="COG3220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620995_0_0_11"/>
    <dbReference type="InParanoid" id="O69833"/>
    <dbReference type="OMA" id="GVWHDSH"/>
    <dbReference type="PhylomeDB" id="O69833"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000192709" description="UPF0276 protein SCO6045">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="UPF0276">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Unknown">
        <location>
            <begin position="274"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="438" mass="46432" checksum="28F9AA7FFCC2A58C" modified="1998-08-01" version="1">MRRLGTGIGWRPEIADAVEEMPGIEWVEAVSENLCPGHLPDSLLRLRERGVTVVPHGVSLGLGGADRPDAGRLAALAERAEALGSPLVTEHIAFVRAGGALTASPSLEAGHLLPVPRTRDALDVLCENVRVAQAALPVPLAVENIAALVSWPDEELTEGQFLYELADRTGVRLLIDVANLHTNHVNRGEDPAEALAGLPLEAIAYVHVAGGFERDGVWHDSHAHPVARPVLDILADLASRVAPPGVLLERDENFPSGDELRGEVEAIRVAVEKGRAAATGTGAAAPTSGTGTDAGSGADDAVRQRLGLAQAALLSALVAGTPVPEGFDRVRLGVQARALAGKRADVVGKVAPELPVILGARYRPAFLAYAQDRPMTGGYRRDALDFVAHVLRTAPGDEGPGVRRELREWWLERSGPVPRSARPGARLARATRRVLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O69859</accession>
    <name>O69859_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO6029</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA19241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34709">
        <property type="entry name" value="T34709"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630140.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972894.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6029"/>
    <dbReference type="GeneID" id="1101470"/>
    <dbReference type="KEGG" id="sco:SCO6029"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6129"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_8_11"/>
    <dbReference type="InParanoid" id="O69859"/>
    <dbReference type="OMA" id="MHRRPPG"/>
    <dbReference type="PhylomeDB" id="O69859"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA19241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="22779" checksum="0EA3409D0BF410BF" modified="1998-08-01" version="1">MSVLLEQPASLVAYRPNKPTAMVVVADPRVRSTVTRHLWALGVRDVIEASSVAEARPRIGNPRDICVADVHLPDGSGLTLLSETRAAGWPNGLALSAADDIGAVRNALAGGVKGYVVTGTRTNVGLPTRPGAAPIGAAAARLHRRPPGAPSHPGGYRELSGREVEVLRLVAEGQSNKAIGVSMGLSALTVKSHLARIARKLGTGDRAGMVAVALRTGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O86494</accession>
    <name>O86494_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6326</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34640">
        <property type="entry name" value="T34640"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630419.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030827.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6326"/>
    <dbReference type="GeneID" id="1101767"/>
    <dbReference type="KEGG" id="sco:SCO6326"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6439"/>
    <dbReference type="eggNOG" id="ENOG50334ZZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118603_1_0_11"/>
    <dbReference type="OMA" id="WGWIHLA"/>
    <dbReference type="PhylomeDB" id="O86494"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="16344" checksum="A047D6AC8E8CBC12" modified="1998-11-01" version="1">MTTSHTHHPAHTARQEWATGLTAFAAVMLFLAGLLSLFRGIMAIAEDDVFVTTPNYVFQFDLTGWGWIHLALGALAMVVSAGLLKTAMWARVTGVAIAGLVIIANFLSLPYYPVWSVVMITMSGFVVWALCVVGRGGNRYDLSGERQSPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O86600</accession>
    <name>O86600_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6235</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAA20611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37233">
        <property type="entry name" value="T37233"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630336.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030757.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6235"/>
    <dbReference type="GeneID" id="1101676"/>
    <dbReference type="KEGG" id="sco:SCO6235"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6349"/>
    <dbReference type="eggNOG" id="ENOG5033NX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131550_0_1_11"/>
    <dbReference type="OMA" id="DWHAFVA"/>
    <dbReference type="PhylomeDB" id="O86600"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="81" mass="8896" checksum="31E040354C132FE6" modified="1998-11-01" version="1">MNTTELAWFKSSYSSGGDGDRVEIALSWHKSSYSSSGDGDCVEVAARPDTIHIRDSKAPHGDQLAVSPTAWTRFLTYTTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O86689</accession>
    <name>O86689_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6643</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35052">
        <property type="entry name" value="T35052"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630719.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031069.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6643"/>
    <dbReference type="GeneID" id="1102082"/>
    <dbReference type="KEGG" id="sco:SCO6643"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6748"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098671_0_0_11"/>
    <dbReference type="InParanoid" id="O86689"/>
    <dbReference type="OMA" id="PRWHADI"/>
    <dbReference type="PhylomeDB" id="O86689"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="184" mass="20126" checksum="99A03175381586CF" modified="1998-11-01" version="1">MRTTDYTIRTATSADVPPARAVMLDTVYRDFRTGYVPRWHGDVIDPAGAYLTPARHTLLVAVAADGEVVGTGALDSRGPAHPPNPPHVAERFPSGVTAQLRRIYVRPEHRRRGLARRLVDELLAFAVADGGYRAVYLHTDPAVTGAEPFWRSLAKVVHDEREDAGGGQGIVHFEVPMAGWRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O86702</accession>
    <name>O86702_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO6520</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
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        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
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        <property type="entry name" value="RNA_pol_sigma70"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="41"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="208"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="266" mass="30005" checksum="4D4552FF066B1D2B" modified="1998-11-01" version="1">MPIHASVKHPHDDAPDTADAFRRLATLPDGPEHDELRDRIVEAWLPMAERLAGRFRSRGESFEDLRQVAALGLVKAVDRYDPERGNAFESYAVPTITGEIKRHFRDHMWTLHVPRRVQELRNRVRFAGQDLSQTIPGRRPTVAEIAERAELSEEDVRVGLEALESFTALSLDAELPGSEDGYSLGDALGAPDPALDTVVDREAVKDRLAALPPRERAILYMRFFNDMTQSRIAEQLGISQMHVSRLITRCCDRVREQVLRDPGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O86709</accession>
    <name>O86709_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6527</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T35219"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6527"/>
    <dbReference type="GeneID" id="1101966"/>
    <dbReference type="KEGG" id="sco:SCO6527"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6630"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014010_0_0_11"/>
    <dbReference type="OMA" id="ADIMVNS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
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        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53649"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="717" mass="76408" checksum="CF91A4A24383A1B8" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O88072</accession>
    <name>O88072_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1615</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36850">
        <property type="entry name" value="T36850"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625891.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027885.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1615"/>
    <dbReference type="GeneID" id="1097046"/>
    <dbReference type="KEGG" id="sco:SCO1615"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1627"/>
    <dbReference type="eggNOG" id="COG2071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030756_4_0_11"/>
    <dbReference type="InParanoid" id="O88072"/>
    <dbReference type="OMA" id="PTYHHQA"/>
    <dbReference type="PhylomeDB" id="O88072"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033969">
        <property type="term" value="F:gamma-glutamyl-gamma-aminobutyrate hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="242" mass="25350" checksum="3578C06BFA5F12DF" modified="1998-11-01" version="1">MADRPLIGVSTYLESGARWGVWELEAALLPAGYPRLVQRAGGLAAMLPPDAPEHAAATVARVDGVVIAGGPDVEPVRYGAEPDPRTGPPARARDTWELALIEAALAARVPLLGICRGMQLLNVALGGTLVQHIERHAEVVGVFGGHPVRPVPGTLYAGAVPEETFVPTYHHQAVDRLGSGLVASAHAADGTVEALEMPSGSGWVLGVQWHPEMGEDVRVMRALVAAARPGRPVTEDRPGPGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>P0A302</accession>
    <accession>P50015</accession>
    <name>ATPZ_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>ATP synthase protein I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">atpI</name>
        <name type="ordered locus">SCO5366</name>
        <name type="ORF">2SC6G5.10</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial AtpI family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629505.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973631.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0A302"/>
    <dbReference type="STRING" id="100226.SCO5366"/>
    <dbReference type="GeneID" id="1100806"/>
    <dbReference type="KEGG" id="sco:SCO5366"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5446"/>
    <dbReference type="eggNOG" id="ENOG5032DKN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124484_0_0_11"/>
    <dbReference type="OMA" id="KILYVEP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000071714" description="ATP synthase protein I">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="144" mass="15062" checksum="D97C67B28C92B9A3" modified="2005-03-15" version="1">MPSNDVRILLQAAVPAAAVGAVAAVVSAVVAGGKGAVGAVVATVLAMLFMGIGLYVLQRTAKSLPHLFQAMGLMLYAAQILLLFVFLAAFKNTTLFNPRSFAVSLLVVTLAWIAAQTRAHMKAKVLYVEPEPTGEKPEKTGHSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-04-01" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>P15360</accession>
    <name>GYLR_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Glycerol operon regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gylR</name>
        <name type="ordered locus">SCO1658</name>
        <name type="ORF">SCI46.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1988" name="J. Mol. Biol." volume="204" first="569" last="580">
            <title>Structure and regulation of controlling sequences for the Streptomyces coelicolor glycerol operon.</title>
            <authorList>
                <person name="Smith C.P."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="3225846"/>
            <dbReference type="DOI" id="10.1016/0022-2836(88)90356-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / J802</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text>May be an activator protein for the gylABX operon.</text>
    </comment>
    <dbReference type="EMBL" id="X14188">
        <property type="protein sequence ID" value="CAA32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC18789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S02066">
        <property type="entry name" value="S02066"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625933.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977167.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P15360"/>
    <dbReference type="SMR" id="P15360"/>
    <dbReference type="STRING" id="100226.SCO1658"/>
    <dbReference type="GeneID" id="1097089"/>
    <dbReference type="KEGG" id="sco:SCO1658"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1675"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_2_11"/>
    <dbReference type="InParanoid" id="P15360"/>
    <dbReference type="OMA" id="HDRRRMP"/>
    <dbReference type="PhylomeDB" id="P15360"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000201756" description="Glycerol operon regulatory protein">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="HTH iclR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="2">
        <location>
            <begin position="82"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00394"/>
        </source>
    </evidence>
    <sequence length="254" mass="27641" checksum="CF3D076E93536179" modified="1990-04-01" version="1">MARNIQSLERAAAMLRLLAGGERRLGLSDIASSLGLAKGTAHGILRTLQQEGFVEQDDASGRYQLGAELLRLGTTYLDVHELRARALVWTDDLARSSGESVHLGVLHQQGVLIVHHVFRPDDSRQVLEIGAMQPLHSTALGKVLSAYDPVAHSEALEADRKAFTDRTVCEPDSFEHVLDITRARGYAADVEETWEGIASIAAPIHDRRRMPVGAVGITGAVERLCREGELRPELVAAVRDCARAVSRDLGAGRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-11-01" modified="2022-05-25" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>P18249</accession>
    <accession>Q9KYU3</accession>
    <name>HRDD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase principal sigma factor HrdD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hrdD</name>
        <name type="ordered locus">SCO3202</name>
        <name type="ORF">SCE22.19c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Mol. Gen. Genet." volume="229" first="334" last="340">
            <title>Nucleotide sequence of genes hrdA, hrdC, and hrdD from Streptomyces coelicolor A3(2) having similarity to rpoD genes.</title>
            <authorList>
                <person name="Tanaka K."/>
                <person name="Shiina T."/>
                <person name="Takahashi H."/>
            </authorList>
            <dbReference type="PubMed" id="1944221"/>
            <dbReference type="DOI" id="10.1007/BF00267453"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1988" name="Science" volume="242" first="1040" last="1042">
            <title>Multiple principal sigma factor homologs in eubacteria: identification of the 'rpoD box'.</title>
            <authorList>
                <person name="Tanaka K."/>
                <person name="Shiina T."/>
                <person name="Takahashi H."/>
            </authorList>
            <dbReference type="PubMed" id="3194753"/>
            <dbReference type="DOI" id="10.1126/science.3194753"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-179</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="X52982">
        <property type="protein sequence ID" value="CAA37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D40116">
        <property type="entry name" value="D40116"/>
    </dbReference>
    <dbReference type="PIR" id="S17931">
        <property type="entry name" value="S11714"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627416.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975615.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P18249"/>
    <dbReference type="SMR" id="P18249"/>
    <dbReference type="STRING" id="100226.SCO3202"/>
    <dbReference type="GeneID" id="1098636"/>
    <dbReference type="KEGG" id="sco:SCO3202"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3262"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_11"/>
    <dbReference type="InParanoid" id="P18249"/>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="PhylomeDB" id="P18249"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0731">Sigma factor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000093994" description="RNA polymerase principal sigma factor HrdD">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Polymerase core binding">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; no nucleotide entry." evidence="3" ref="3">
        <original>F</original>
        <variation>I</variation>
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; no nucleotide entry." evidence="3" ref="3">
        <original>Q</original>
        <variation>H</variation>
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA37174." evidence="3" ref="1">
        <original>T</original>
        <variation>H</variation>
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="332" mass="37155" checksum="BEAC010BBC0C442B" modified="2001-10-18" version="2">MATRAVARRKSAAGETSGSATSVRANGGELADRDLVGMYLDEIARTPLLDAAKEVELSQTIEAGVFARQVLEGYEETGADATREELQALIDESERAKDVFIRSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYRKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREFNREHGREPEPAEIAAELGSTPERVTDVLDWARDPVSLNMSVDDEGETQFGDLLEDTSAVSPEQSVLTLLRSEELDDLIGRLDPRTASIIKMRYGIDDGRERTLTEVGKEHGLTRERIRQIEKHALLELKKLARDTGFEAAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>P66233</accession>
    <accession>Q9L0M5</accession>
    <name>RL332_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L33 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmG2</name>
        <name type="ordered locus">SCO4635</name>
        <name type="ORF">SCD82.06</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628796.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003948671.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P66233"/>
    <dbReference type="SMR" id="P66233"/>
    <dbReference type="STRING" id="100226.SCO4635"/>
    <dbReference type="GeneID" id="1100076"/>
    <dbReference type="GeneID" id="24311058"/>
    <dbReference type="GeneID" id="67399973"/>
    <dbReference type="KEGG" id="sco:SCO4635"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4706"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_11"/>
    <dbReference type="InParanoid" id="P66233"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="PhylomeDB" id="P66233"/>
    <dbReference type="PRO" id="PR:P66233"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000170242" description="50S ribosomal protein L33 2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="54" mass="6406" checksum="5D0E205FFD69A93D" modified="2004-10-11" version="1">MAATDVRPKITLACVECKERNYITKKNRRNNPDRLEMKKHCPRCNAHTAHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKI4</accession>
    <name>Q7AKI4_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ordered locus">SCO5046</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629198.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030021.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5046"/>
    <dbReference type="GeneID" id="1100487"/>
    <dbReference type="KEGG" id="sco:SCO5046"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5126"/>
    <dbReference type="eggNOG" id="ENOG5032S23">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106245_6_0_11"/>
    <dbReference type="OMA" id="LQPEPYG"/>
    <dbReference type="PhylomeDB" id="Q7AKI4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAC05891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="125" mass="13917" checksum="A3B341D3E12D12EA" modified="2012-05-16" version="1">MLQPPHSSLQVAAVPAQRVPVRDRDQDAPWHTEAVCRRDEAGLFFAPSKEPTAARLSREEAAKRVCARCPVMVECREHALLQPEPYGVWGGLTAAERRVVLARRRRRDVELRNAARTTGRIAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q7BR72</accession>
    <accession>Q7AKS2</accession>
    <name>Q7BR72_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe regulatory protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">furA</name>
        <name evidence="4" type="ordered locus">SCO0561</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2000" name="J. Bacteriol." volume="182" first="3767" last="3774">
            <title>Regulation of the furA and catC operon, encoding a ferric uptake regulator homologue and catalase-peroxidase, respectively, in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Hahn J.-S."/>
                <person name="Oh S.-Y."/>
                <person name="Roe J.-H."/>
            </authorList>
            <dbReference type="PubMed" id="10850993"/>
            <dbReference type="DOI" id="10.1128/JB.182.13.3767-3774.2000"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">A3</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">A3</strain>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AF126956">
        <property type="protein sequence ID" value="AAF78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB57413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624874.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978301.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0561"/>
    <dbReference type="GeneID" id="1095984"/>
    <dbReference type="KEGG" id="sco:SCO0561"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.542"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_0_11"/>
    <dbReference type="OMA" id="DHPHADT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CollecTF" id="EXPREG_00000fe0"/>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CollecTF"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB57413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="151" mass="15977" checksum="A245CF689BE5C0C8" modified="2004-07-05" version="1">MTASRNSRKPATADELRRAGLRVTAARVALLETVRAGDHLDAEALTSGVRRRVGHVSLQAVYDALHALTAARLVRRIEPPGSPARFEGRVGDNHHHVLCRSCGALADVDCAVGDAPCLTASDDRGFVIDEAEVIYRGLCPDCSTPGSSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJT4</accession>
    <name>Q8CJT4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4530</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAD55487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733641.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974411.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4530"/>
    <dbReference type="GeneID" id="1099970"/>
    <dbReference type="KEGG" id="sco:SCO4530"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4603"/>
    <dbReference type="eggNOG" id="ENOG50333W1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117215_0_0_11"/>
    <dbReference type="OMA" id="LYFFADH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="186" mass="20038" checksum="94D357541F5F4B76" modified="2003-03-01" version="1">MRLWSYGRCDGDDVTGQTGTRTPGAVRGVLKGALGGVHRRVRHRVDAAREAATTRGDDSGMTAIEFVLLTPVLFFMIFATVQFGLYFFADHVAQAAAQAGARKARATADAQPGAWRGEARDVVDSYIRQLGPQLVLSPDVKMVQPEQNTVGVEITARIPTVFPGLDLTVHAQSMGPVERFVQEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J22</accession>
    <name>Q93J22_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3985</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628168.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029357.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3985"/>
    <dbReference type="GeneID" id="1099421"/>
    <dbReference type="KEGG" id="sco:SCO3985"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4055"/>
    <dbReference type="eggNOG" id="ENOG5031SQC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193085_0_0_11"/>
    <dbReference type="OMA" id="HCAGPLH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="74" mass="7966" checksum="D2D629EE79E29D24" modified="2001-12-01" version="1">MSGWVPGGALASNVEITAATVLRGDIIQVGGRACRVSDLFQLPQGAKQLLFDSGELLTINGRTRLVAVRMTRRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JL5</accession>
    <name>PCKG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="1">PEP carboxykinase</shortName>
            <shortName evidence="1">PEPCK</shortName>
            <ecNumber evidence="1">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pckG</name>
        <name type="ordered locus">SCO4979</name>
        <name type="ORF">2SCK36.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629131.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973998.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q93JL5"/>
    <dbReference type="SMR" id="Q93JL5"/>
    <dbReference type="STRING" id="100226.SCO4979"/>
    <dbReference type="GeneID" id="1100420"/>
    <dbReference type="KEGG" id="sco:SCO4979"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5060"/>
    <dbReference type="eggNOG" id="COG1274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_11"/>
    <dbReference type="InParanoid" id="Q93JL5"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="PhylomeDB" id="Q93JL5"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000103615" description="Phosphoenolpyruvate carboxykinase [GTP]">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="276"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="518"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <sequence length="609" mass="66917" checksum="80FF6E00B817875A" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RW4</accession>
    <name>Q93RW4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1862</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626129.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028017.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1862"/>
    <dbReference type="GeneID" id="1097296"/>
    <dbReference type="KEGG" id="sco:SCO1862"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1887"/>
    <dbReference type="eggNOG" id="ENOG5034BBF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102961_0_0_11"/>
    <dbReference type="OMA" id="RHEPAKE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176598" evidence="2">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="160" mass="15565" checksum="AD51F55D6B309F8E" modified="2001-12-01" version="1">MFLVLLLIVVVAVVSAVGLTGHGASVLAARRARGTGAGPALRALAAFAGAAAVAMYAWGLLHVTGAVMESDGGAGSAPAPPCRTTGNEERALHVIDQSVSFLPLGFVCETTGGGEYTSDDVPGYVNPATAALALTAVAGAVGAGYASEARARATARGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RZ4</accession>
    <name>Q93RZ4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0576</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC39638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624889.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027214.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0576"/>
    <dbReference type="GeneID" id="1095999"/>
    <dbReference type="KEGG" id="sco:SCO0576"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.557"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087850_0_0_11"/>
    <dbReference type="OMA" id="VAHPCHP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031663">
        <property type="entry name" value="PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037161">
        <property type="entry name" value="Semialdehyde_DH-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16896">
        <property type="entry name" value="PGDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="1">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PGDH_C" evidence="2">
        <location>
            <begin position="131"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC39638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="291" mass="31502" checksum="2C2C432843520ABE" modified="2001-12-01" version="1">MATEIQTRADVQTVAVIGAAGKMGQRVSNNLVDSDFRVLFSEASPTGQELIRDLGRELTESAAAAAEADVVILAVPDVVLGKVSEELVPLMKPGTVVLTLDPAAAYAGLLFAREDIHYACAHPCHPSVFLERTTKEEWQDTFGGIAAPQEVVAAYEGGDAAKQELADSVIRVMYAPVVDVHWVTVKQLAVLEPTLVETIACMVGALLTEALHETVHTVGVPEKAARAMLLGHTQVALANTLKGSNPFSDACLIAMDYGRESIVREDWKKVFDDEELDKVITRMLRIKEIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q99Q18</accession>
    <name>Q99Q18_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetaldehyde dehydrogenase [acetylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCP1.300</name>
        <name evidence="5" type="ordered locus">SCP1.54c</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="7">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">A3</strain>
            <plasmid evidence="7">SCP1</plasmid>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:23288"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the acetaldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639629.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639909.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039355.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095133"/>
    <dbReference type="GeneID" id="1095382"/>
    <dbReference type="KEGG" id="sco:SCP1.300"/>
    <dbReference type="KEGG" id="sco:SCP1.54c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8002"/>
    <dbReference type="HOGENOM" id="CLU_062208_0_0_11"/>
    <dbReference type="OMA" id="IPAYAGN"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01657">
        <property type="entry name" value="Ac_ald_DH_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003361">
        <property type="entry name" value="Acetaldehyde_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015426">
        <property type="entry name" value="Acetylaldehyde_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09290">
        <property type="entry name" value="AcetDehyd-dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015689">
        <property type="entry name" value="Actaldh_dh_actl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="4">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC36576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC36825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="293" mass="30594" checksum="D5908995517643D7" modified="2001-06-01" version="1">MTPHARLNTAVLGTGPLGLDLIERIHASPYLNSPLVVGHRPGSRGLAQAADLGCVTRSGGIDAVLDADRSVDVVFDATNAFAHPAHWDKLADTGAILIDLTPTTTGTLIVPTVNGHQAAHHQHIGLVSCSGQAALPILHAVTSRHPAAAVEMVATAASASVGRASRLNLDEYLDTTQQAIRCFTHAPDAKTMINISAATPAPPFRTAITVITADPAPADDIATLTASVEQKMRALVPGYHVTSCTSEDRTVRVVVEVTATRSRIPVHAGNLEVISAAAIHAAEQRAQHQEAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACY8</accession>
    <name>Q9ACY8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCP1.163</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639736.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039462.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095241"/>
    <dbReference type="KEGG" id="sco:SCP1.163"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8109"/>
    <dbReference type="HOGENOM" id="CLU_045117_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ACY8"/>
    <dbReference type="OMA" id="RQFHGCY"/>
    <dbReference type="PhylomeDB" id="Q9ACY8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="182"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="374" mass="42634" checksum="32D6458471AED556" modified="2001-06-01" version="1">MVAEPVRVRRLTDQEGPKLQQIVRRGSTSTVRFRRAMMLLASAGGNRVPVIAKLVQADEDTVRDVIHRFNEIGLACLDPQWAGDRPRLLSDDDEDFVIQTATTRPTKLGQPFTRWSIRKLAAYLRRVDGRVFRIGREALRCLLARRGITFQRTKTWKESPDPDRDAKLDRIEHVLERFPDRVFAFDEFGPLGIRPAAGSCWAEQGRPERHPATYHRTHGVRYFHGCYAIGDDTLWGVNRRKKGADNTLAALKSIRAARPDGAPIYVILDNLSAHKGARTRAWATKNRVELCFTPTYASWANPIAAHFGPLRQFTVANSHHRSHPTQTRALHAYLRWRNKNARHPEVLAAQRKERARVRSEKGTRWGGRPITEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADE3</accession>
    <name>Q9ADE3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5064</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629215.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030030.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5064"/>
    <dbReference type="GeneID" id="1100505"/>
    <dbReference type="KEGG" id="sco:SCO5064"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5143"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_4_11"/>
    <dbReference type="InParanoid" id="Q9ADE3"/>
    <dbReference type="OMA" id="HRMGQVR"/>
    <dbReference type="PhylomeDB" id="Q9ADE3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="340"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="584"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC37452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="800" mass="86476" checksum="283BD6CAA2A9BF97" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADF4</accession>
    <name>Q9ADF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6109</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAC33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630217.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030657.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6109"/>
    <dbReference type="GeneID" id="1101550"/>
    <dbReference type="KEGG" id="sco:SCO6109"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6212"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029441_0_0_11"/>
    <dbReference type="InParanoid" id="Q9ADF4"/>
    <dbReference type="OMA" id="DILIRWA"/>
    <dbReference type="PhylomeDB" id="Q9ADF4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176609" evidence="2">
        <location>
            <begin position="32"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="52476" checksum="B10B56C2AF2E5B1E" modified="2001-06-01" version="1">MFAMPRSARLTALSAALLAGALASSSTPALATAGAPATEAKLDFAVRLTIGTDYRACSGALVDAQWVLTAASCFADDPAQSVAVPAGKPERLTRATVGRADSGVANGYVREVVELVPHPNRDMVLARLDKAVPDIAPVPLAAGAPDPGAPLTAVGFGRTKDEWVPVQRHQAAFTVTSVTADAVNVTGQDGGAVCAGDAGGPLLQSKDGAPQLVGVNSRSTQGGCFGSDATSTAAVAAASDADFVRQTVNRDLGTGNLSDLVASADFNADGRTDIAAVLDDGSLHAFYTKPDGTLEYGRELWNDNTWGPMVQIIGGDFDDDGNGDIAAVRSDGTLNLYTGTPTGMLNKSKPMWHDTSWKTIEQVSRFTFGGRDGLIAQWGNGNLYGYYTGADGVLTGEKVKMWPDATWSTTRLTGTTDVNADGRDDLVAVRDDGSLNWYAGNSAGGLDLARKLWPDNTWTPMKRVVGGDFNGDGKGDVAAVGGQGTLLLYTGTGTGTLNKGVAMRPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADQ5</accession>
    <name>Q9ADQ5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4000</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628182.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029371.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4000"/>
    <dbReference type="GeneID" id="1099436"/>
    <dbReference type="KEGG" id="sco:SCO4000"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4065"/>
    <dbReference type="eggNOG" id="ENOG5030GT7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150704_0_0_11"/>
    <dbReference type="OMA" id="MLEGYPC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="159" mass="17517" checksum="068314C83115CE58" modified="2001-06-01" version="1">MHDRPRVPTLSLTRIVLSCGRSVELTELRLTPTYGDMPAGYPCRPVNDLRIRALLHTAAGLSPTVPVHLIPPSREYPDQYAGAFGPVETLPRVACVGRFSSMPLAPAKDPVAHRSGLTVIWFQPTTRVPDPYDADPALRQVDWTSLAQDYELEGMPYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADQ6</accession>
    <name>Q9ADQ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3999</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628181.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029370.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3999"/>
    <dbReference type="GeneID" id="1099435"/>
    <dbReference type="KEGG" id="sco:SCO3999"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4064"/>
    <dbReference type="eggNOG" id="ENOG5032UK2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060528_0_0_11"/>
    <dbReference type="OMA" id="WRNTTEF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="376" mass="37823" checksum="38CF79107C83EA86" modified="2001-06-01" version="1">MVGVRWGWWGGEMRIPPFRTALAVSGVLVAGLVLGGCGTESAGSAAGGGGETTGPCAGGAADDHGASGGTNGAGEERDGVRVVGTVERDGAGVNASPSGRASQRPGVSVTADSLPGAGGAAGPCVVQYDVTNPGAEPFTYTITFSLMDEQGRAMSNVEETVASVGAGKTVRRTLEHGGYPGGGVLDAGRVRILDVERVPSDEAPAPASSCPASGLRLTADQGDAAMGLRVVGLHLENCGSRTYSLEGYPVLQLLDAEHQPVDGIEILRGTDGIPMAGGDEGPPRPVTLRPGESAVSGLAWRNTTEFGEAVTVPYVRVRAEAGADPVTVAPHLDLGTTGELGVRPWRKDETEAGRGTGDSGSGRPGAQGPYGMPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWJ3</accession>
    <name>Q9EWJ3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7591</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631633.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971552.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7591"/>
    <dbReference type="GeneID" id="1103029"/>
    <dbReference type="KEGG" id="sco:SCO7591"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7707"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_39_3_11"/>
    <dbReference type="InParanoid" id="Q9EWJ3"/>
    <dbReference type="OMA" id="LFWHRDR"/>
    <dbReference type="PhylomeDB" id="Q9EWJ3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="320" mass="33749" checksum="F6EBD45C62A20D84" modified="2001-03-01" version="1">MNSTDPTAPVIDANLAVALDALLAEQSVTRAAARMRTSPAAMSRTLGRLRRLLQDPLLVRAGQTMVPTPRALALRDEAATVVRRLGALLTPATGVDPATLRSTFSLQTADLVGAALAAGLLTLAGQEAPGVSLRFRAEELEAGPALRDGRVDLEVGAIDHVDPETRVEELVTLRMTAAVRPGHPLTEGPLTAARFAAAEHVGVSRRGRFDGPVDAALAEHGLSRRVSVVLPGHLAALSLAARTDVVALVPAARDEADFSPSPLTEQARVLGLCLLDIPLPLPPVTIGMAWHPRHTADGAHHWLRAAVRRVLRAEPSARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EX11</accession>
    <name>Q9EX11_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BcrAD_BadFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1115</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAC13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625408.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027584.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1115"/>
    <dbReference type="GeneID" id="1096538"/>
    <dbReference type="KEGG" id="sco:SCO1115"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1112"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_4_0_11"/>
    <dbReference type="InParanoid" id="Q9EX11"/>
    <dbReference type="OMA" id="GHLLGDC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="77"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="332" mass="33040" checksum="CC04DED7F745C920" modified="2001-03-01" version="1">MSTGFLAVDSGGSGLRAVVGAVGDGGHAGDCGHGPLGRRVSRDPVRTGAHGIDPGHLLGQLLPMARALTAESGVTRIDTVVVGAAGLATLGDALRAELPGALARELGVRTVALVADAVTAYVGALGPRAGAVVAAGTGLIAVGTDLARWRRADGWGHLLGDCGGGAWIGRAGLEAALRAHDGREDGSAPLLARAEERFGPAAGLPAQVYPRPDRPAVLASFAPEVAACAATDPVAAEILGAAARHLADSAAAVCPSAGEPLVAVTGGLTRLGDPLLVPLGDELAKRLPQARWTAAEGDPLDGSVRVATDLATGSFTLPGDDRMLWVTTAPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F359</accession>
    <name>Q9F359_STRCO</name>
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            <fullName evidence="4">Putative secreted protein</fullName>
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        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Mce"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        </location>
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        <location>
            <begin position="113"/>
            <end position="290"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="35412" checksum="5CEE46DF4A482851" modified="2001-03-01" version="1">MTRRRKILTGVLALVVLAAGGLAAARALGPGGTRVTAYFDRAIGVYAGSDLRILGVRVGEVESVDPEGTRVRVGLRLDDGIKVPEDARAVVVAPSVVADRYVQLTPAYRTGPALADGAVLPASRNHVPVEIDQIYDSITELGDALGPDGANADGALSELLRTGADNLDGNGEAIGDGVEQFGKAAKTLDGSSGDLFETLSSLQTFTTMLKNKDTDVRTAQERLDEVVSFFADNKDDLTGALEELGKALGQVKTFIEDNRGELKKNVDRLVPITRTLVEQRASLAEALDVAPLAADNVVNAYNPDTRTLDGRANLNEISSGGPLLPLPVAGTEKGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3E4</accession>
    <name>Q9F3E4_STRCO</name>
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        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">SCO7613</name>
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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                <person name="Parkhill J."/>
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            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
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        <property type="protein sequence ID" value="CAC16715.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="1103051"/>
    <dbReference type="KEGG" id="sco:SCO7613"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7730"/>
    <dbReference type="eggNOG" id="COG3087">
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    <dbReference type="HOGENOM" id="CLU_315898_0_0_11"/>
    <dbReference type="OMA" id="WVRLAAW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAC16715.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="818" mass="81909" checksum="DEBB1742A92C1AAA" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBX5</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Putative TetR-family transcriptional regulator</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">SCO7809</name>
    </gene>
    <organism evidence="4">
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        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
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                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
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            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000036.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="1103247"/>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.7920"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC03627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="210" mass="22654" checksum="C0993D0EA579F2FE" modified="2001-03-01" version="1">MSEQQPNLRERRRSETRRLVQAHAVRLFTDHGYDAVTVADVAEAAGVSAMTVYRHFPTKEDLVLIDQPAQLIAEHVAASSAAQPLVRRVGSALIDAATNWTGGNGDEQAANERFLLDCLRLMVSTPALRARHLDSQYALQQAIVDALGDDATGPDAAFRAQAATSACIAAMHTALTRWVEDDGHTKLPDLIARALTASFGDDAVATRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC40</accession>
    <name>Q9FC40_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7043</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7043"/>
    <dbReference type="GeneID" id="1102481"/>
    <dbReference type="KEGG" id="sco:SCO7043"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7147"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_10_2_11"/>
    <dbReference type="InParanoid" id="Q9FC40"/>
    <dbReference type="OMA" id="VRRIGQW"/>
    <dbReference type="PhylomeDB" id="Q9FC40"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC01541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="110" mass="12531" checksum="C1E11EDB5005075E" modified="2001-03-01" version="1">MEGHGTGGPARREDEMLRTPVHGTRLDILEWLKDPAAHFPPQRHADPAEHGVHAGPVAARLGVSRRVAETHLGLLTRLGLLRATRIRRRTYYRRDEVRIAEVARMFEKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCE8</accession>
    <name>Q9FCE8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4222</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628397.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029513.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4222"/>
    <dbReference type="GeneID" id="1099662"/>
    <dbReference type="KEGG" id="sco:SCO4222"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4285"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108054_0_0_11"/>
    <dbReference type="InParanoid" id="Q9FCE8"/>
    <dbReference type="OMA" id="FWCEVLD"/>
    <dbReference type="PhylomeDB" id="Q9FCE8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="126" mass="14275" checksum="5797786D62CEC22C" modified="2001-03-01" version="1">MACRISELVLGCRDPEALARFWCEVLDFVVLDREDNEYFEIGPREGFGGPQPTIILSRRDEPEPGKSRLHIDVNATDRDQDAELERLLELGARPTDIGQTGEEQWHVLADPEGNEFCLLKARLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3M7</accession>
    <name>Q9K3M7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1033</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB96018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625328.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977796.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1033"/>
    <dbReference type="GeneID" id="1096456"/>
    <dbReference type="KEGG" id="sco:SCO1033"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1028"/>
    <dbReference type="eggNOG" id="ENOG5033FA6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159099_1_3_11"/>
    <dbReference type="OMA" id="PGPWILF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB96018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="94" mass="10232" checksum="E6C7F1202D603358" modified="2000-10-01" version="1">METLAQFGDGGPGPWILLFPVIWALVIGGGITLLRRTVWRGRRGPGRPGAVEDNSPITVLGHRFASGEIDEDEYWRRLSVLDEQFGRTGKGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Y7</accession>
    <name>Q9K3Y7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1346</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625631.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027734.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1346"/>
    <dbReference type="GeneID" id="1096769"/>
    <dbReference type="KEGG" id="sco:SCO1346"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1353"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_11"/>
    <dbReference type="InParanoid" id="Q9K3Y7"/>
    <dbReference type="OMA" id="KHMVDAG"/>
    <dbReference type="PhylomeDB" id="Q9K3Y7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="25938" checksum="608F0D5C1AE55A8A" modified="2000-10-01" version="1">MSTTEQRVAVVTGAARGIGAATALRLAAEGRAVAVIDLDEAACKDTVEKITAAGGKAIAVGCDVSDEAQVEAAVARIAEELGAPTILVNNAGVLRDNLLFKMSVSDWDTVMNVHLRGAFLMTKACQKHMVDAKFGRVVNLSSSSALGNRGQVNYSAAKAGLQGFTKTLAKELGKFGVTANAVAPGFIATEMTKATADRVGMGFDDFKAAAATQIPVARVGEPDDIANAIAFFTGEAAGFVSGQVLYVAGGPLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K499</accession>
    <name>CYC1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Epi-isozizaene synthase</fullName>
            <shortName>EIZS</shortName>
            <ecNumber>4.2.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Sesquiterpene cyclase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Sesquiterpene synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cyc1</name>
        <name type="ordered locus">SCO5222</name>
        <name type="ORF">SC7E4.19</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="J. Am. Chem. Soc." volume="128" first="6022" last="6023">
            <title>Genome mining in Streptomyces coelicolor. Molecular cloning and characterization of a new sesquiterpene synthase.</title>
            <authorList>
                <person name="Lin X."/>
                <person name="Hopson R."/>
                <person name="Cane D.E."/>
            </authorList>
            <dbReference type="PubMed" id="16669656"/>
            <dbReference type="DOI" id="10.1021/ja061292s"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>COFACTOR</scope>
        <scope>KINETIC PARAMETERS</scope>
        <scope>REACTION MECHANISM</scope>
        <scope>REACTION STEREOCHEMISTRY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cyclization of farnesyl diphosphate (FPP) to the sesquiterpene epi-isozizaene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25992"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:51458"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="4.2.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit. Can also use Mn(2+) and Fe(3+) but less efficiently, and other divalent cations such as Zn(2+), Fe(2+), Co(2+), Cu(2+) and Ni(2+) are nearly completely inefficient as cofactors.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="1">147 nM for FPP</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text>Sesquiterpene biosynthesis; epi-isozizaene biosynthesis.</text>
    </comment>
    <comment type="domain">
        <text>The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.37"/>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB94607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629369.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030119.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="PDB" id="3KB9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="3KBK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="3LG5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.64 A"/>
        <property type="chains" value="A=1-361"/>
    </dbReference>
    <dbReference type="PDB" id="3LGK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LTV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LTZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LUU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LXW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.09 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LZ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.75 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LZ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDB" id="4LZC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.46 A"/>
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    <dbReference type="PDB" id="6AX9">
        <property type="method" value="X-ray"/>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
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    <dbReference type="PDB" id="6AXN">
        <property type="method" value="X-ray"/>
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        <property type="resolution" value="1.91 A"/>
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        <property type="method" value="X-ray"/>
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        <property type="resolution" value="2.20 A"/>
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        <property type="resolution" value="1.50 A"/>
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    <dbReference type="PDB" id="7KJG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.30 A"/>
        <property type="chains" value="A=2-361"/>
    </dbReference>
    <dbReference type="PDBsum" id="3KB9"/>
    <dbReference type="PDBsum" id="3KBK"/>
    <dbReference type="PDBsum" id="3LG5"/>
    <dbReference type="PDBsum" id="3LGK"/>
    <dbReference type="PDBsum" id="4LTV"/>
    <dbReference type="PDBsum" id="4LTZ"/>
    <dbReference type="PDBsum" id="4LUU"/>
    <dbReference type="PDBsum" id="4LXW"/>
    <dbReference type="PDBsum" id="4LZ0"/>
    <dbReference type="PDBsum" id="4LZ3"/>
    <dbReference type="PDBsum" id="4LZC"/>
    <dbReference type="PDBsum" id="6AX9"/>
    <dbReference type="PDBsum" id="6AXM"/>
    <dbReference type="PDBsum" id="6AXN"/>
    <dbReference type="PDBsum" id="6AXO"/>
    <dbReference type="PDBsum" id="6AXU"/>
    <dbReference type="PDBsum" id="6OFV"/>
    <dbReference type="PDBsum" id="7KJ8"/>
    <dbReference type="PDBsum" id="7KJ9"/>
    <dbReference type="PDBsum" id="7KJD"/>
    <dbReference type="PDBsum" id="7KJE"/>
    <dbReference type="PDBsum" id="7KJF"/>
    <dbReference type="PDBsum" id="7KJG"/>
    <dbReference type="AlphaFoldDB" id="Q9K499"/>
    <dbReference type="SMR" id="Q9K499"/>
    <dbReference type="STRING" id="100226.SCO5222"/>
    <dbReference type="GeneID" id="1100663"/>
    <dbReference type="KEGG" id="sco:SCO5222"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5306"/>
    <dbReference type="eggNOG" id="ENOG5033S8Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042538_4_1_11"/>
    <dbReference type="InParanoid" id="Q9K499"/>
    <dbReference type="OMA" id="DLIEYAM"/>
    <dbReference type="PhylomeDB" id="Q9K499"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-13904"/>
    <dbReference type="BRENDA" id="4.2.3.37">
        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q9K499"/>
    <dbReference type="UniPathway" id="UPA00195"/>
    <dbReference type="EvolutionaryTrace" id="Q9K499"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052680">
        <property type="term" value="F:epi-isozizaene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000247894" description="Epi-isozizaene synthase">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DDXXD motif">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="69"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="257"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="337"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16669656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="3LGK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7KJD"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7KJG"/>
        </source>
    </evidence>
    <sequence length="361" mass="41388" checksum="227B08D792F36BB7" modified="2000-10-01" version="1">MHAFPHGTTATPTAIAVPPSLRLPVIEAAFPRQLHPYWPKLQETTRTWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGAPDEVLQAIADYSAWFFVWDDRHDRDIVHGRAGAWRRLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFARHFHTVIEAYDREFHNRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKHPAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVRRRVEECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVNNEAAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4H0</accession>
    <name>Q9K4H0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4168</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628344.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029479.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4168"/>
    <dbReference type="GeneID" id="1099608"/>
    <dbReference type="KEGG" id="sco:SCO4168"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4233"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_11"/>
    <dbReference type="InParanoid" id="Q9K4H0"/>
    <dbReference type="OMA" id="FSSISYM"/>
    <dbReference type="PhylomeDB" id="Q9K4H0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB94072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="28136" checksum="2F9EBA70CF4C64E3" modified="2000-10-01" version="1">MPLRRTVTDMDMNYAHRYEGRRALVTGGGSGIGQATVLRLLAEGGSVVAADVSEPGLKDTVEKAGAHAERLTTLVVDIADETSVREGVRAATEALGGLDVLVNAAGILRSSHTGQTSLADFTRVLTVNLVGTFLVIREAVPALLEGRDAAVVNFSSTSAAFAHPYMAAYAASKGGIQSMTHALAAEYAGRGIRFTAVQPGSISSGMTDGSGASGQSVGPGLPEDADMALFAKLSPALGRGFAGPETVASVVAMLASEDGRFITGTEVRVDGGTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXN3</accession>
    <name>Q9KXN3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4324</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628495.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974651.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4324"/>
    <dbReference type="GeneID" id="1099764"/>
    <dbReference type="KEGG" id="sco:SCO4324"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4393"/>
    <dbReference type="eggNOG" id="ENOG50347P2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171891_0_0_11"/>
    <dbReference type="OMA" id="VCMLMGV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="92" mass="9465" checksum="32FCCA70F59A06AF" modified="2000-10-01" version="1">MREQTQTNSAAPGDRLIRAGAIVFFVGALATLVTVAPLLLDTTPFPTYMFGLSMLMGVGFLVAGAGVLRSIAAGRRQARAASSPSASPSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXP1</accession>
    <name>Q9KXP1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1509</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB93389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625789.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977317.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1509"/>
    <dbReference type="GeneID" id="1096935"/>
    <dbReference type="KEGG" id="sco:SCO1509"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1518"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_0_11"/>
    <dbReference type="InParanoid" id="Q9KXP1"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="PhylomeDB" id="Q9KXP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB93389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="235" mass="24500" checksum="721AD870AB994D55" modified="2000-10-01" version="1">MLIAGFPAGAWGTNCYLVAPAAGEECVIIDPGHQAAPGVEEAIRKHRLKPVAVVLTHGHIDHVASVVPVCGAHDVPAWIHPEDRFMMSDPEKGIGRSIGMPLMGELTVGEPDDVKELTDGARLALAGLELTVAHAPGHTKGSVTFGLPEAADIPPVMFSGDLLFAGSIGRTDFPGGSMDDMLESLARVCLPLDDSTVVLSGHGPQTTIGQERATNPYLRQVAAGQGAPDAPRRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXZ0</accession>
    <name>Q9KXZ0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2425</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626669.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028345.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2425"/>
    <dbReference type="GeneID" id="1097859"/>
    <dbReference type="KEGG" id="sco:SCO2425"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2466"/>
    <dbReference type="eggNOG" id="ENOG5032YPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080913_0_0_11"/>
    <dbReference type="OMA" id="WAPFTRC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176750" evidence="1">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="313" mass="31791" checksum="969F68D169A1A353" modified="2000-10-01" version="1">MPRISTRTRLAAVSALTALGAFASLGTATAAEPALNGEWAPFTRCPVDAPAMLAADGFDKTPQCVVSTSASGSIKLGDTTVTTGRTNLQMGIVQNADGTSSVVAPASGALVAEPATVPGGLLGLMCPSDIFVITGICESLENSSLNKITATMESVGAPYAFDQTAGVLTDMPIVALPVRIHLENPLLGDKCYIGTAAKPIVLRPENRDYPEAGLSFFQGDGTADPAGEMSRINLTGATQNDSTFAVPGATGCGLNVGLINLAVNAKTGLPSAAGNNSLTLNDTRTHLTGLNAPGTVVPDAGKVLAENWHSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY31</accession>
    <name>Q9KY31_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2359</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626606.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028304.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2359"/>
    <dbReference type="GeneID" id="1097793"/>
    <dbReference type="KEGG" id="sco:SCO2359"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2398"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_2_11"/>
    <dbReference type="InParanoid" id="Q9KY31"/>
    <dbReference type="OMA" id="RECFGPS"/>
    <dbReference type="PhylomeDB" id="Q9KY31"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="284"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB92835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="372" mass="39778" checksum="668621FA3695F81B" modified="2000-10-01" version="1">MRCGAGLILGTAAAAVELLFALLAGVALLPVAAWPKGRRAVLRPVLAGARILAELERGRLRMWLDLRVTPAYEDVRALRYVACHWALGVLGGVVMLTAAIGLAYGTFGVYGWLLLDGIRNPGSLVLGSLGGFFLVFLTVQGIFGVVGLEGQLARHFLGPRHQEELERRIAELSASRAAVVDAVNDERRRIERDLHDGVQQRLVALGMLLGRARRSQDADRRDRLLGQAHDESRRALDELREVAWRIYPTTLDEAGLRAALETVAERASVPVGVEYALAEEPEQAVATVAYFVVCEAVTNAVKHAAPTRISVAVRAEEKRMYVSVRDDGCGGANAAGSGLFGLARRVAALDGSLSVDSPPGGPTLVAAELPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY83</accession>
    <name>Q9KY83_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5019</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAB92612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629171.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030007.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5019"/>
    <dbReference type="GeneID" id="1100460"/>
    <dbReference type="KEGG" id="sco:SCO5019"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5097"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359723_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KY83"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004329863" evidence="1">
        <location>
            <begin position="28"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="201" mass="20936" checksum="81A73021F6CC8530" modified="2000-10-01" version="1">MPISASATASFPLPGLSSLPHADSVKAAVAVSVSAVKRAGQRALTIGSWVGRGFSSAKQFCTEGIGMGRQRWRDGAGALVVVGQSGEGACVPLEIAGSYRARTKGLLGRGSVDGAMLLTPANSVHTFRMRMAIDVAYLDRRLNVIAVRTMRPGRLGLPRLRARHVLEAEAGAMDEWGVRVGARVEVVEGSAESADGAGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYB5</accession>
    <name>Q9KYB5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6918</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630985.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031300.1">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="580" mass="63206" checksum="3A2DC208A7FEF054" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYD4</accession>
    <name>Q9KYD4_STRCO</name>
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        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6896</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB92558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630965.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031281.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6896"/>
    <dbReference type="TCDB" id="2.A.1.21.19">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="GeneID" id="1102335"/>
    <dbReference type="KEGG" id="sco:SCO6896"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7005"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_668890_0_0_11"/>
    <dbReference type="OMA" id="IVGFDKM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="411" mass="41535" checksum="EC7E274FCB938F68" modified="2000-10-01" version="1">MSAAVTPRHARHPAGLVGSIYLPRTADALAFAMSTYGIPLLVLSTTRSAALTGAAFTLEWIPRLAAFGWAGSIVDRRGAAVVFHLASLGRALVLAAGAVLLYLYPSGAVASVTVMVLAAATGVLTQFSYVAVETAGAAAGRRAGPRAHRVQAVLLGIDQTATLAGPALAGVLLLAGPPSMLAVVTGFSLLAAMLALRTPPSPVLPARAPKGRPGAGLVTGGRTIRALPALGWLVAGLALSNLATGLLQAAGPVIVVQHFGQSTTAVGLVWSAAAAATLVAVTICRFALDRLGLWPVGVACSVIASLACLAAALAPDYLSYLVMVAVLMAADGGLAVVLRTLRSRLIPPEVFGSTLSATILILLLPFPVAGVLTALTPPDALGHVITACAALQTLGLFCAFARLRTDPALRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYE2</accession>
    <name>Q9KYE2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4128</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB92381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628306.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974842.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4128"/>
    <dbReference type="GeneID" id="1099568"/>
    <dbReference type="KEGG" id="sco:SCO4128"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4190"/>
    <dbReference type="eggNOG" id="ENOG502Z8K6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038805_0_0_11"/>
    <dbReference type="OMA" id="CDREHHR"/>
    <dbReference type="PhylomeDB" id="Q9KYE2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="513" mass="57030" checksum="BBECF123F5395A3D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYH5</accession>
    <name>Q9KYH5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2697</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626931.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028522.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2697"/>
    <dbReference type="GeneID" id="1098131"/>
    <dbReference type="KEGG" id="sco:SCO2697"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2753"/>
    <dbReference type="eggNOG" id="COG3860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_1_0_11"/>
    <dbReference type="OMA" id="RYLIDDM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="1">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="192" mass="20434" checksum="E9029D9FD0F2E53E" modified="2000-10-01" version="1">MASALAALPALFAEESRVRAFAAVALGAGDAAQVAGAAGLSAKETAGALRRLREQGVVTSGDDGGLVVAHGRFRELARVGRTESAAPRDAAAAGDGGPGDMIVRTFVRNGRLVRLPARWTRKKVVLRHIAEQTFAPGVEYPERTVDEKLRAWCEDGEVDHVTLRRHLVDFGHLRRSDGVYTRPADSARTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYI3</accession>
    <name>Q9KYI3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2689</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939113">
        <property type="protein sequence ID" value="CAB92255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626923.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976110.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2689"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1098123"/>
    <dbReference type="KEGG" id="sco:SCO2689"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2745"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696216_0_0_11"/>
    <dbReference type="InParanoid" id="Q9KYI3"/>
    <dbReference type="OMA" id="IYFRRTA"/>
    <dbReference type="PhylomeDB" id="Q9KYI3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB92255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="375" mass="40833" checksum="C82E530C42E18971" modified="2000-10-01" version="1">MTGFLLPNARLTPQEHPGAATSALPPVTVLVPFYRETAAILRRSADMLRSLDYPHDRLSVCWLVDARYPEDVAAAENVAASARADFGGGLRVVPVPSMTPKAKALNHALRSVDDPFVALYDADTVPDPRQLRQAVAALDARGLDVVDAIELPEAGGDLVNRITLAQSAAFFGAMEYVNRRTGMHMLLGSSIYFRRTALSKVGPLSEDGVEELYEWAVRAAAAGVRMGRIVSFSYGTRTSVVGPALRQRTRWIRGQLDIGVRFLGGKPLPARPRTAVALMTLSLLGQLGVLPVTAAAVRYRALRLPAAALLLGEALRVRSVSRDPVWEVLRIGSGWALLLPFELLESTSAWRAVWELATGRDTWHKVRPETGERTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYU1</accession>
    <name>Q9KYU1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MarR-family transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3205</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="Nucleic Acids Res." volume="41" first="7009" last="7022">
            <title>Investigation of DNA sequence recognition by a streptomycete MarR family transcriptional regulator through surface plasmon resonance and X-ray crystallography.</title>
            <authorList>
                <person name="Stevenson C.E."/>
                <person name="Assaad A."/>
                <person name="Chandra G."/>
                <person name="Le T.B."/>
                <person name="Greive S.J."/>
                <person name="Bibb M.J."/>
                <person name="Lawson D.M."/>
            </authorList>
            <dbReference type="PubMed" id="23748564"/>
            <dbReference type="DOI" id="10.1093/NAR/GKT523"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB90989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627419.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028826.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="PDB" id="3ZPL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B/E/F=1-163"/>
    </dbReference>
    <dbReference type="PDBsum" id="3ZPL"/>
    <dbReference type="SMR" id="Q9KYU1"/>
    <dbReference type="STRING" id="100226.SCO3205"/>
    <dbReference type="GeneID" id="1098639"/>
    <dbReference type="KEGG" id="sco:SCO3205"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3265"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_2_2_11"/>
    <dbReference type="InParanoid" id="Q9KYU1"/>
    <dbReference type="OMA" id="KNGWVRR"/>
    <dbReference type="PhylomeDB" id="Q9KYU1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB90989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3ZPL"/>
        </source>
    </evidence>
    <sequence length="163" mass="18848" checksum="B14C8E803737A977" modified="2000-10-01" version="1">MNDEPRWLTAEEQLVWRSYIEAATLLEDHLDRQLQRDAGMPHVYYGLLVKLAESPRRRLRMTELAKYAKITRSRLSHAVARLEKNGWVRREDCPSDKRGQFAILTDEGYEVLRRTAPGHVDAVRQAVFDRLTPEQQKSLGEIMRIVAEGLQPSEAGADLPWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYW9</accession>
    <name>Q9KYW9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO3012</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB90923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627234.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028715.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3012"/>
    <dbReference type="GeneID" id="1098445"/>
    <dbReference type="KEGG" id="sco:SCO3012"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3071"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_18_11"/>
    <dbReference type="InParanoid" id="Q9KYW9"/>
    <dbReference type="OMA" id="NRFWRSD"/>
    <dbReference type="PhylomeDB" id="Q9KYW9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="284"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="351"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB90923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="688" mass="72805" checksum="BBE0FC89DE86066A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZC9</accession>
    <name>Q9KZC9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6960</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631026.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972186.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6960"/>
    <dbReference type="GeneID" id="1102398"/>
    <dbReference type="KEGG" id="sco:SCO6960"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7060"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118001_0_0_11"/>
    <dbReference type="OMA" id="CRPRQDA"/>
    <dbReference type="PhylomeDB" id="Q9KZC9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032582">
        <property type="entry name" value="DUF4916"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16262">
        <property type="entry name" value="DUF4916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="178" mass="19499" checksum="4FAC8279C9319F4A" modified="2000-10-01" version="1">MSDMTETTPGWLTSDELEMARARMPILYVEAVPVRVDDSGEVTSVGLLLRIGPDGTVSRTLVSGRVLHHERVRDALLRHLEKDLGPVALPRVPPSLQPFTVAEYFPTHGVTPYHDPRQHAVSLAYVVPVTGDCRPRQDALDLVWFDPREALSEAVRSEMPGGHGVLLKQALAHVGCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN1</accession>
    <name>Q9KZN1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1401</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625684.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977425.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1401"/>
    <dbReference type="GeneID" id="1096827"/>
    <dbReference type="KEGG" id="sco:SCO1401"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1410"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_1_1_11"/>
    <dbReference type="InParanoid" id="Q9KZN1"/>
    <dbReference type="OMA" id="GEHMAAE"/>
    <dbReference type="PhylomeDB" id="Q9KZN1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="14900" checksum="461EC289CFC0EE1A" modified="2000-10-01" version="1">MTAPKATGHTATRSGELNWLLDDLVDRVASIRKAVVLSGDGLATGVSKDLTREDSEHLAAVASGFHSLAKGVGRHFEAGSVRQTVVELDEAFLFVTAAGDGSCLAVLSDADSDVGQVAYEMTLLVKRVGVHLGTAPRTDPPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZN6</accession>
    <name>Q9KZN6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO1396</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625679.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027763.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000029.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KZN6"/>
    <dbReference type="STRING" id="100226.SCO1396"/>
    <dbReference type="GeneID" id="1096822"/>
    <dbReference type="KEGG" id="sco:SCO1396"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1405"/>
    <dbReference type="eggNOG" id="COG2173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060744_0_1_11"/>
    <dbReference type="InParanoid" id="Q9KZN6"/>
    <dbReference type="OMA" id="EWWHFTY"/>
    <dbReference type="PhylomeDB" id="Q9KZN6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176790" description="D-alanyl-D-alanine dipeptidase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="30864" checksum="9C74518D694F315D" modified="2000-10-01" version="1">MTRLSAALRGLATTFAALLAVTAVPAASAPATAQARHEPRAPEDFVALRGVDPTIIEEMRYVTAHNFVGERVDGYRQPLCILTRPAAEALHLAQTRLLRQGYSLKVYDCYRPQRAVDHFVRWAEDLDDQDMKAEFYPDVDKTRLFADGYIAEKSGHSRGSTVDLTLVRLPAKPTRPYHPGQPLVPCFAPKGERFPDNSVDMGTGYDCFDTRSHTLDPRIEGVQRANRLLLKDTLEEAGLVNLPEEWWHFTYKPEPYPDTYFDFPVSAKSLSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZV4</accession>
    <name>Q9KZV4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4147</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628324.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974822.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4147"/>
    <dbReference type="GeneID" id="1099587"/>
    <dbReference type="KEGG" id="sco:SCO4147"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4211"/>
    <dbReference type="eggNOG" id="COG3806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061391_0_0_11"/>
    <dbReference type="OMA" id="DPTYEMA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="287" mass="29554" checksum="14953711EBFAE645" modified="2000-10-01" version="1">MRIEESRPRDAWHVDEDDLRAYARGELAAPALWSTDAHLTACATCRGVLARVSDAAALDAGWARLDAELDAPRPGWFERLLVRCGAGDGTARLLAATPILRRSWFGALAAVLFVTFLVAVSAGAAGRPTLFLVCAPLLPLVSVALAYGPALDPTHEMAVVSPMHGFRLLMIRTVAVLVVALGVGGLASLALPGYGPAALAWLLPGLALTATGLALTPRLGPVLAPSVLVCAWAAVLLAADAARASTDGPLAPFTAAGQGVSGLVAVLGAGLLFLFRDRFDVSARGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZW0</accession>
    <name>Q9KZW0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO4141</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628318.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029460.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4141"/>
    <dbReference type="GeneID" id="1099581"/>
    <dbReference type="KEGG" id="sco:SCO4141"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4205"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_11"/>
    <dbReference type="InParanoid" id="Q9KZW0"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="PhylomeDB" id="Q9KZW0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="96"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB88474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="336" mass="35640" checksum="6DA61B82F2B0C618" modified="2000-10-01" version="1">MDITTDTQQPAPSRTPQPPATEDTRPGRGVTRPGDRIFVGLSRGSGILVLVIMAAIAAFLTYRAVLAIGEDEANFFTSFEWNPTGSPPEFGIAVLAYGTVVSSIIAMAIAVPVSVGIALFITHYAPRKLGGLIGYVIDLLAAVPSIVYGLWGALVLVPHLNGLYGWLDEYLGWTGIFEWNGGAGRSLLTVGILLAIMILPIITNVSREVFRQVPRMHEEAALALGATRWEVIRMSVLPFGRSGVISASMLGLGRALGETMAVAMVLSPTFDITPSLLDPGGGTFAQNIASKFNEATQMGRDALIASGLVLFVITLLVNGGARMIIARRKEYSGANA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0D2</accession>
    <name>RL29_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmC</name>
        <name type="ordered locus">SCO4710</name>
        <name type="ORF">SCD31.35</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628869.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974259.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9L0D2"/>
    <dbReference type="SMR" id="Q9L0D2"/>
    <dbReference type="STRING" id="100226.SCO4710"/>
    <dbReference type="GeneID" id="1100151"/>
    <dbReference type="KEGG" id="sco:SCO4710"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4781"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_3_3_11"/>
    <dbReference type="InParanoid" id="Q9L0D2"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="PhylomeDB" id="Q9L0D2"/>
    <dbReference type="PRO" id="PR:Q9L0D2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000130466" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="74" mass="8402" checksum="D9C82FF343F09189" modified="2000-10-01" version="1">MSAGTKASELRELGNEELLAKLREAKEELFNLRFQAATGQLENHGRLKAVRKDIARIYTLMRERELGIETVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0P5</accession>
    <name>Q9L0P5_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phage_base_V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4246</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB77340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628420.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029529.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4246"/>
    <dbReference type="GeneID" id="1099686"/>
    <dbReference type="KEGG" id="sco:SCO4246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4309"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462110_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L0P5"/>
    <dbReference type="OMA" id="TNMEFLR"/>
    <dbReference type="PhylomeDB" id="Q9L0P5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="385"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB77340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="643" mass="68080" checksum="81C41E8CA1BEFCB2" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L189</accession>
    <name>Q9L189_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative secreted serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7386</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631438.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031628.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7386"/>
    <dbReference type="GeneID" id="1102824"/>
    <dbReference type="KEGG" id="sco:SCO7386"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7494"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030648_2_0_11"/>
    <dbReference type="OMA" id="YTGNVRC"/>
    <dbReference type="PhylomeDB" id="Q9L189"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176820" evidence="7">
        <location>
            <begin position="31"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_Al_protease" evidence="8">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB76287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="390" mass="40313" checksum="9BF1E29F3746587F" modified="2000-10-01" version="1">MRRSRLRHLGLAGLLVLGSLTAVGTLPASAADAPAHSPSSSEQPASAGLLDAMQRDFGLTRAEAEDRLAAEREATGIEPAARRAAGKAFGGSWFDAEAGRLTVAVTSDATPSALRAVRATGAQVRTVEHSAQQLDAAKARVDRLDAPAGVSSWRADRATNKVVVDVVAGERADNDVQSFLKQARATAPVTVRTVPSAPQTFAAGTVGGDPYYTGNVRCSIGFSVHGGFVTAGHCGRAGAGVSGWDRSYIGTFQGSSFPDNDYAWVSVGSGWWTVPVVLGWGTVSDQLVRGSNVAPVGASICRSGSTTHWHCGTVLAHNETVNYSDGSVVHQLTKTSVCAEGGDSGGSFISGDQAQGVTSGGWGNCSSGGETWFQPVNEILNRYGLTLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1E3</accession>
    <name>Q9L1E3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5462</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629599.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030265.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5462"/>
    <dbReference type="GeneID" id="1100902"/>
    <dbReference type="KEGG" id="sco:SCO5462"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5546"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112477_0_0_11"/>
    <dbReference type="OMA" id="TMNPRFL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="22128" checksum="42CEE106E39F3A3B" modified="2000-10-01" version="1">MAESLREILDAAARGVFPAADGGTSVVPQFGGRDAGVIAFTAHSVVFTDEDEGWVRRTLASLGCDPLAATMNARFLAAFAERTGRATDTIDVLLTGAPLPGRPEGALEEVADPGHPRVVAARRRRDGVRVWAADGGVLVLGRGVGGRLEVAVEVAEGARHRGLGRRLVTAARQLAGGEVVWAQVSAGNARSLRAFQAAGYRPVGSEALFLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2J0</accession>
    <name>Q9L2J0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625024.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027314.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096142"/>
    <dbReference type="KEGG" id="sco:SCO0719"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.707"/>
    <dbReference type="eggNOG" id="ENOG5033198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109389_0_0_11"/>
    <dbReference type="OMA" id="DDAYQPT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043763">
        <property type="entry name" value="DUF5709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18970">
        <property type="entry name" value="DUF5709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5709" evidence="2">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="158" mass="16443" checksum="E0DF5CB123927F5C" modified="2000-10-01" version="1">MGTDPMADDAYQPTGGNEEQEDAAPLDLQDALDERTYDDTLDEGYSPPEKPLGVTKHGTTAAEQHEGETLDERLAEEVPDVSAPDGDGVGDEPDGEGEPVDPEAGTDRSGRLVAPDEGVRADTTKETVAEDVGIDGGAAGAEEAAVHVVEDETQLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RCV6</accession>
    <name>Q9RCV6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0855</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB65636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625155.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027394.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0855"/>
    <dbReference type="GeneID" id="1096278"/>
    <dbReference type="KEGG" id="sco:SCO0855"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.847"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116318_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RCV6"/>
    <dbReference type="OMA" id="YRVGPDY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB65636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="168" mass="18177" checksum="274BCA9C99C988B0" modified="2000-05-01" version="1">MGNTLRMSPRTSPVSPPITIRRAVARDAKRLTRLVRGSGAYAGQYAAAVAGYRVGPDYIEAHRVFVAVGADGEGGRVLGFYSLVLVPPELDLLFVADEAQGRGIGRLLVAHMRSEARAAGLDRVRVVSHLPAEGFYHRVGAVRTGTVRASPPAVPWDRPEFEFRVDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD35</accession>
    <name>Q9RD35_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO0874</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939107">
        <property type="protein sequence ID" value="CAB62665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625174.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977985.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0874"/>
    <dbReference type="GeneID" id="1096297"/>
    <dbReference type="KEGG" id="sco:SCO0874"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.865"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073293_2_1_11"/>
    <dbReference type="InParanoid" id="Q9RD35"/>
    <dbReference type="OMA" id="WSWADPV"/>
    <dbReference type="PhylomeDB" id="Q9RD35"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAB62665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="230" mass="23776" checksum="D81A8C0F933F3D3E" modified="2000-05-01" version="1">MTAVSLGPSPARRDALARRIRLLVTATIGYNVVEAVVAITAGTIASSTALIGFGLDSVIEVSSAAAVAWQFSARDPAVREAREKRTLRIIAFSFFALALYVTVDSVRALTGTGEAGHSVPGIVLAGLSLAIMPFLSAAQRKAGREIGSASAVADSKQTLLCTYLSAVLLVGLLVNLLLGWTWADPVAALVISAIAVKEGRDAWQGRGCCAAPTWATPQAGADTDNCDCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDC1</accession>
    <name>Q9RDC1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable amino acid ABC transporter protein, integral membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO2830</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB65560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627059.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975970.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2830"/>
    <dbReference type="GeneID" id="1098264"/>
    <dbReference type="KEGG" id="sco:SCO2830"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2888"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RDC1"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="PhylomeDB" id="Q9RDC1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014341">
        <property type="entry name" value="Ectoine_EhuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03003">
        <property type="entry name" value="ectoine_ehuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB65560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="216" mass="24343" checksum="3CA6AD17A44C5FA9" modified="2000-05-01" version="1">MKWDWSAVSDFMPHFWDGLLVTLQILVLGSLVSFGLGLVWALLMRVPSRWVTWPVGVVTEFVRNTPLLVQLFFLFYVLPEWNITFSALTTGVVAIGLHYSTYTMQVYRAGIEGVPVGQWEAATALNLPMRRTWTAVILPQAIRRVTPALGNYVISMLKDTPLLMAITVLEMLGEARLFSQQNFQFTEPLTVIGVAFIVISYLASLALRALERRLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDQ2</accession>
    <name>Q9RDQ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2382</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626628.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028317.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2382"/>
    <dbReference type="GeneID" id="1097816"/>
    <dbReference type="KEGG" id="sco:SCO2382"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2423"/>
    <dbReference type="HOGENOM" id="CLU_131550_2_0_11"/>
    <dbReference type="OMA" id="KDPQGPQ"/>
    <dbReference type="PhylomeDB" id="Q9RDQ2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="65" mass="6944" checksum="F283FA15A0650DCE" modified="2000-05-01" version="1">MRSRTALSNVEWRKSSYSGSNGGDCVEVAENRPTGTVPVRDSKNPAGPVVTLGAHAWQAFVDGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDQ8</accession>
    <name>Q9RDQ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2376</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB62708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626622.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976427.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2376"/>
    <dbReference type="GeneID" id="1097810"/>
    <dbReference type="KEGG" id="sco:SCO2376"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2417"/>
    <dbReference type="eggNOG" id="ENOG502ZA0Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082127_0_0_11"/>
    <dbReference type="OMA" id="GYGPVHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027860">
        <property type="entry name" value="DUF4429"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14472">
        <property type="entry name" value="DUF4429"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4429" evidence="2">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4429" evidence="2">
        <location>
            <begin position="137"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="31730" checksum="FE8B3A677A451189" modified="2000-05-01" version="1">MGDVLAGFHAAWEFESDSVLIRYERGIRTPKLFQALGERRVPLEAIEGVTLTPGRRGTVVLRVEPRAGADPLIEAAAGQLKEGGDPYRLVLPADRETLAEYYADELRALLTESGRTERYLVAPPEAPLHFKAYDGKASFDGKAVSFRWSWTGASSAKWKAGDQSFPVADLGGVEWRSPEMFEGYLRLLPRDADASVAGAAAGAAPAVPQADQDPAAVVFGLGYGPVHESLPFAAAVLAAVRERGASAPVPIPVPAPRRDPADIAERIRHLGELHQQGLVTDEEFSSKKAELLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDR3</accession>
    <name>Q9RDR3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2254</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626503.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028228.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2254"/>
    <dbReference type="GeneID" id="1097687"/>
    <dbReference type="KEGG" id="sco:SCO2254"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2291"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_61_2_11"/>
    <dbReference type="InParanoid" id="Q9RDR3"/>
    <dbReference type="OMA" id="LGTWIGQ"/>
    <dbReference type="PhylomeDB" id="Q9RDR3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB66188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="413" mass="40902" checksum="E321329F2DEE8BE9" modified="2000-05-01" version="1">MPLALLALAVGAFGIGTTEFVMMGLLPDVADDLGISIPTAGHLVSAYALGVVIGAPLLAAVTTRMSRRAVLIALMALFVVGNALSAVAPGEISLLAARFVSGLPHGAFFGVGAVVATGMVAPERKARSVSLMFLGLTVANIVGVPAATAMGQQLGWRATFLGVSAIGVAAIAALAFLIPRDSAPAPTTGLRGELAALRSLPVWLALGTTVAGFGALFAAYSYITPMLTDAAGFAESSVTLLLALFGVGATAGNLLGGRLADHSLRGTLFGGLASLVVVLALFPLLMRTPVTAAASVALLGMAAFVTGSPLQLMVMEKAAAAPSLASSANQAAFNLANAGGAWIGGLALAAGFGATSPATAGAALAVLGLAVAGTAWTVDRRRAVLAPVPGRERVVAGHVPDSDRAASHAGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI92</accession>
    <name>Q9RI92_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0083</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36983">
        <property type="entry name" value="T36983"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624431.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026834.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0083"/>
    <dbReference type="GeneID" id="1095511"/>
    <dbReference type="KEGG" id="sco:SCO0083"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.71"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RI92"/>
    <dbReference type="OMA" id="SKHHVIV"/>
    <dbReference type="PhylomeDB" id="Q9RI92"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="131"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="282" mass="32028" checksum="6466248AA511390F" modified="2000-05-01" version="1">MPCPARELSVRFGVGTSPWIVSDELWDRVEPLLPQRERRFRHPGRKPLPDRDVLCGILYVLHTGIPWEYLPRGLGFGSGMPCWRRLRDWNEAGVRQRLHEILLAELNAAARLDRSRCVVDSPRQGAKGGQHTGPSPVDRGRAGSKHHLITDGHGTPLAVLLTGGNRNDVTQLLPLLDAIPPVRGPVGRPRRKPDSLFADRGYDHDIYRDQARTRGIVPAIARRGTLHGAALGTYRWVVERSLAWLHGFRRLRIRWERRADIHEALLRLACCLITHRQLRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ34</accession>
    <name>Q9RJ34_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1834</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626102.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976988.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1834"/>
    <dbReference type="GeneID" id="1097268"/>
    <dbReference type="KEGG" id="sco:SCO1834"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1856"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158326_0_0_11"/>
    <dbReference type="OMA" id="GDIGARC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13685" checksum="824A500F6B39C164" modified="2000-05-01" version="1">MTGVSDGAGELLEPLARVAPGERGATRIADRVVAKVAARAAREALGPLHPDAARPYATVDVHHDTAHVRVHLELDYPCDIGARCGQVRHQVVQRVRALVGMAVPEVAVRVERLHLAAQYGARHGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJD7</accession>
    <name>Q9RJD7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">SCO0755</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625058.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027333.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0755"/>
    <dbReference type="MEROPS" id="C39.005"/>
    <dbReference type="GeneID" id="1096178"/>
    <dbReference type="KEGG" id="sco:SCO0755"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.746"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_95_3_11"/>
    <dbReference type="InParanoid" id="Q9RJD7"/>
    <dbReference type="OMA" id="CACVVIA"/>
    <dbReference type="PhylomeDB" id="Q9RJD7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022514">
        <property type="entry name" value="NHPM_micro_ABC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03796">
        <property type="entry name" value="NHLM_micro_ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="11">
        <location>
            <begin position="35"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="190"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="506"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="540"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAB61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="740" mass="79889" checksum="591ADC993375A3A7" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJI7</accession>
    <name>Q9RJI7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0401</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB59810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624723.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027086.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0401"/>
    <dbReference type="GeneID" id="1095824"/>
    <dbReference type="KEGG" id="sco:SCO0401"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.377"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_4_11"/>
    <dbReference type="InParanoid" id="Q9RJI7"/>
    <dbReference type="OMA" id="GYNGWHD"/>
    <dbReference type="PhylomeDB" id="Q9RJI7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB59810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="441" mass="46923" checksum="035B3FE3775AFAA7" modified="2000-05-01" version="1">MNAEELGLPRSRQANERLHALVPGGAHTYAKGDDQYPENLAPVISHGRGAHVWDVDGNRYVEYGSGLRSVSLGHAHPRVTEAVRRELDRGSNFVRPSIVEVDAAERFLATVPTAEMVKFAKNGSDATTAAVRLARAATGRPRVAVCADHPFFSVDDWFIGTTPMSAGIPAATNELTVAFPYGDLAATEDLLARHEGEVACLILEPATHTEPPPGYLAGLRELADRHGCVLVFDEMITGFRWSEAGAQGLYGVVPDLSTFGKALGNGFAVAALAGRRELMELGGLRHSGDRVFLLSTTHGAETHALAAAMAVQGTYVEEGVTARLHALGDRLAAGVREAAASMGVGDHVVVRGRASNLVFATLDENGQPSQRYRTLFLRQLLAGGVLAPSFVVSSALGDADLDHTVDVVAEACAVYRKALDAADPTPWMAGRPVKPVFRRLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJM5</accession>
    <name>NADE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="1">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadE</name>
        <name type="synonym">nadE2</name>
        <name type="ordered locus">SCO0506</name>
        <name type="ORF">SCF6.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB58266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624822.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027169.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJM5"/>
    <dbReference type="SMR" id="Q9RJM5"/>
    <dbReference type="STRING" id="100226.SCO0506"/>
    <dbReference type="GeneID" id="1095929"/>
    <dbReference type="KEGG" id="sco:SCO0506"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.486"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RJM5"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="PhylomeDB" id="Q9RJM5"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152204" description="NH(3)-dependent NAD(+) synthetase">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <sequence length="276" mass="29755" checksum="299DAF941293422E" modified="2000-05-01" version="1">MSEPASIALQKEIVRELEVAETFDAEREIERRVAFLAERLTSTGLRALVLGISGGVDSTTAGRLCQLAVERARAAGHEALFYAMRLPHGVQADEDDAQQALSFIRPDRVLTVDIKPASDAALDALLAADVAFRDPHHQDFVHGNIKARQRMIAQYAVAGAHGGLVVGTDHAAEAVSGFFTKFGDGAADVVPLTGLTKRRVRAVGDALGAPAALVRKVPTADLETLDPGKADEDALGVTYEEIDDFLEGKPVTEQVFETIVTRYRQTDHKRRLPIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJU6</accession>
    <name>Q9RJU6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624687.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027055.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0364"/>
    <dbReference type="GeneID" id="1095787"/>
    <dbReference type="KEGG" id="sco:SCO0364"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.340"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_11"/>
    <dbReference type="InParanoid" id="Q9RJU6"/>
    <dbReference type="OMA" id="RCIKEAV"/>
    <dbReference type="PhylomeDB" id="Q9RJU6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="268" mass="28281" checksum="D22F87FD5A47391C" modified="2000-05-01" version="1">MSDTGHLPPPDLGTDLVLLDVTDRVAILTLNRPAKLNAVTPGMSRALVRAIEWCDTTDEVRALVVTGAGERSFSVGSDIGALDQYATPWDFRNRVDYCDAIRAARTPTVAAVGGYALGGGLETALSCDIRLAADTASFGAPEITLGWIGGGGMTAFLSRAAGPGNAALMLLTGERIDAERALAWHLVSEVVPRAGLLDRARALAAVIASRAPVAAETAKINLRAAGNLPEDQALAYERDLQTICFATEDAAEGRRAFAEKRSPVFHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK33</accession>
    <name>Q9RK33_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0683</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB60464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624991.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978180.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0683"/>
    <dbReference type="GeneID" id="1096106"/>
    <dbReference type="KEGG" id="sco:SCO0683"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.669"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118613_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RK33"/>
    <dbReference type="OMA" id="INVGRLH"/>
    <dbReference type="PhylomeDB" id="Q9RK33"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="174" mass="17771" checksum="1F5FB1FE48D49A4A" modified="2000-05-01" version="1">MAVESDVLDELHRLRNRVPQLTGSLAATVDGLVLAHDAPGTEPEGLAALTAAALGVAHRMAEATARGGFRELLLRGADGYVATYAAGPAAVLTLLADGRVNVGRLHLEGRRSGARIGELVAAGIGAERGRAPAAGHGATLPAQPPRPIGTLPVRTPQRPAHQPTPQAGGTHRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKA6</accession>
    <name>Q9RKA6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO3182</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627397.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975635.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9RKA6"/>
    <dbReference type="STRING" id="100226.SCO3182"/>
    <dbReference type="GeneID" id="1098616"/>
    <dbReference type="KEGG" id="sco:SCO3182"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3242"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKA6"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="PhylomeDB" id="Q9RKA6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB59678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="303" mass="33128" checksum="A7B021D1F1266939" modified="2000-05-01" version="1">MTQSHPRISKAVIPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEAVTAGLGDVLMVTGRNKRPLEDHFDRNYELESALQKKGDASRLAKVQESSDLAMMHYVRQGDPKGLGHAVLCAAPHVGHEPFAVLLGDDLIDPRDPLLQRMIDVQEQYGGSVIALMEVAPEQIHLYGCAAVESTADSDVVKVGGLVEKPDPADAPSNYAIIGRYVLDPHVFDILRKTEPGRGGEIQLTDALQQLAEDESVGGPVHGVVFKGRRYDTGDRGDYLRAIVRLACEREDLGPDFRTWLRSYVAEEMQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKB3</accession>
    <name>Q9RKB3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exodeoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO3174</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627390.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028810.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3174"/>
    <dbReference type="GeneID" id="1098608"/>
    <dbReference type="KEGG" id="sco:SCO3174"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3234"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RKB3"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="PhylomeDB" id="Q9RKB3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331855" evidence="2">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="30321" checksum="7C76E49C5F913591" modified="2000-05-01" version="1">MCRYRAGMLTVTSVNVNGLRAAAKKGFVEWLAGTSADVLCLQEVRAEPHQLPDHAGAPEGWHVTHAPAAAKGRAGVSLYTRREPDAVRVGFGSTEFDTSGRYVEADLPGVTVASLYLPSGEVGTERQDEKVRFMGEFLAYLKELRERAAAQGREVVVCGDWNIAHREADLKNWRANKKNSGFLPEEREWLGRVLDPAEGGYVDVVRALHPDVEGPYSWWSYRGRAFGNDAGWRIDYHVSTPGLAAKAVKGYVERAATHAERWSDHAPVTVVYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKC8</accession>
    <name>Q9RKC8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3159</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB59655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627375.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028801.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3159"/>
    <dbReference type="GeneID" id="1098593"/>
    <dbReference type="KEGG" id="sco:SCO3159"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3219"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKC8"/>
    <dbReference type="OMA" id="LLLMQPI"/>
    <dbReference type="PhylomeDB" id="Q9RKC8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="8">
        <location>
            <begin position="256"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB59655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="353" mass="35817" checksum="28EAD85821C3DC23" modified="2000-05-01" version="1">MHVPDGFINAPTSAVTGVVAAGAIAVSLRGARRELDERTAPLAGLVAAFIFAVQMLNFPVAAGTSGHLLGGALAAILVGPCTGVLCVSVVLLMQGILFADGGLTALGVNITDMAIVTTVVAYALFRGLVKVLPRTRRSVTVASFVAALVSVPAAALAFTLLYWIGGTTDVSIGKVATAMIGVHLLIGIGEAAITALTVGAVIAVRPDLVYGARGLQQRLKLRVNGELVDAPGAGPAPVPAPVAARSHRKVWITGLVASLVLAGFVSFYASADPDGLEKVASDKGIDEKAKEHANADSPLADYGVEDITNARVSGGLAGVIGVGVTVVAGSAVFWAVRRRRSEDASPTSTETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKM6</accession>
    <name>Q9RKM6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4101</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB56382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628281.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029433.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4101"/>
    <dbReference type="GeneID" id="1099538"/>
    <dbReference type="KEGG" id="sco:SCO4101"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4160"/>
    <dbReference type="eggNOG" id="ENOG5031JFA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969306_0_0_11"/>
    <dbReference type="OMA" id="DGEYGPS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="14392" checksum="B49834A372DE5B0D" modified="2000-05-01" version="1">MPAWTTPRRLGVVTTLYAVFLAGWWLGQPVRSDGCVEDRIAAGADARPAPVEPADTGRYFGNLDLGFGLLDFGLLDWADDLDGYRDGEYGPSDYGYDLQGGPQTYDTAGADHAPCSYKKRARLLAWVNGDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKP1</accession>
    <name>Q9RKP1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2287</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50596">
        <property type="entry name" value="T50596"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626535.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028252.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2287"/>
    <dbReference type="GeneID" id="1097720"/>
    <dbReference type="KEGG" id="sco:SCO2287"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2324"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_11"/>
    <dbReference type="InParanoid" id="Q9RKP1"/>
    <dbReference type="OMA" id="ANVQFMT"/>
    <dbReference type="PhylomeDB" id="Q9RKP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="263" mass="27260" checksum="F3D5E450D9830295" modified="2000-05-01" version="1">MNTVRTTDEESAGARKVAVVTGAGSGIGRAVAVELLTAGWSVALAGRRPEPLAETAAAAPAGGGTALTVRADVSRPEDVAALFGAVRDRFGRLDLLFNNAGTFGPGGVPVEDLPYEAWRHVVDTNLNGAFLCAQAAYRQMKEQDPRGGRIINNGSISAHTPRPHSVAYTATKHALTGLTKSLSLDGRPYGIAVGQIDIGNAATEMTAGMQTGALQANGETAPEPVMDVADVARTVRHMAELPLEANVQFATVMATAMPYVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKT7</accession>
    <name>Q9RKT7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6255</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630355.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972671.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6255"/>
    <dbReference type="GeneID" id="1101696"/>
    <dbReference type="KEGG" id="sco:SCO6255"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6369"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_0_2_11"/>
    <dbReference type="InParanoid" id="Q9RKT7"/>
    <dbReference type="OMA" id="QVHAVNI"/>
    <dbReference type="PhylomeDB" id="Q9RKT7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB60174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="337" mass="36000" checksum="29E6473A3ACD1997" modified="2000-05-01" version="1">MRIGVIGTGRIGTVHANTLSRHRDVGSLILTDADIARAQELAHRLGETAAPGVDEIFQWGVDAVVITTATPAHAELIGRAARSGLPVFCEKPIALDLPGTLQAIAEVEAAGTVLQMGFQRRFDTGYTGAREAVRSGRLGRLHTVRAVTSDQTPPPADYLPQSGGLYRDTLIHDFDVLRWVTGREVVDVYAAGSDAGPPMFRAADDVDTGAVLLTLDDGTLATATAARLNGAGYDVRMELAGELDQIVVGLDDRTPIASTEPTGPPAADKPWTGFVERFGPAYEAELTTFVQVVRGERANPCDGREALQALRIAEACDVSRRERRPVRLAEVPETLTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKU5</accession>
    <name>ALLB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Allantoinase</fullName>
            <ecNumber evidence="1">3.5.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Allantoin-utilizing enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">allB</name>
        <name type="ordered locus">SCO6247</name>
        <name type="ORF">SCAH10.12</name>
        <name type="ORF">STAH10.12</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation allows a single lysine to coordinate two zinc ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630347.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972680.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKU5"/>
    <dbReference type="SMR" id="Q9RKU5"/>
    <dbReference type="STRING" id="100226.SCO6247"/>
    <dbReference type="PRIDE" id="Q9RKU5"/>
    <dbReference type="GeneID" id="1101688"/>
    <dbReference type="KEGG" id="sco:SCO6247"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6361"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_4_0_11"/>
    <dbReference type="InParanoid" id="Q9RKU5"/>
    <dbReference type="OMA" id="WVTAEVT"/>
    <dbReference type="PhylomeDB" id="Q9RKU5"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01645">
        <property type="entry name" value="Hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0659">Purine metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000165943" description="Allantoinase">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01645"/>
        </source>
    </evidence>
    <sequence length="445" mass="47492" checksum="75955C5F98632570" modified="2000-05-01" version="1">MSEAELVLRSTRVITPEGTRAASVAVTGEKITAVLPYDAPVPAGARLEDVGDHVVLPGLVDTHVHVNDPGRTEWEGFWTATRAAAAGGITTLVDMPLNSIPPTTTVDNLRTKREVAADKAHIDVGFWGGALPDNVKDLRPLHEAGVFGFKAFLSPSGVDEFPHLDQEQLARSLAEIAAFDGLLIVHAEDPHHLAAAPQQGGPKYTHFLASRPRDAEDTAIATLLAQAKRFNARVHVLHLSSSDALPLIAEARADGVRVTVETCPHYLTLTAEEVPDGASEFKCCPPIREAANQDLLWQALADGTIDCVVTDHSPSTADLKTDDFATAWGGIAGLQLSLPAMWTAARGRGLGLEDVVRWMSERTAALVGLDARKGAIAPGHDADFAVLAPDETFTVDPAALQHRNRVTAYAGKTLYGVVKSTWLRGERIVADGAFTDPKGQLLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S229</accession>
    <name>Q9S229_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1771</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36874">
        <property type="entry name" value="T36874"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626042.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027966.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1771"/>
    <dbReference type="GeneID" id="1097202"/>
    <dbReference type="KEGG" id="sco:SCO1771"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1788"/>
    <dbReference type="eggNOG" id="ENOG5032YHZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102567_0_0_11"/>
    <dbReference type="OMA" id="HYEARPE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="185" mass="19243" checksum="0AC304744B91D73F" modified="2000-05-01" version="1">MSLPGADELFRTTGGTALQASTPRRPAGGEARVPAPAGESDQAAAEDAPQSVPAQGGDGEGAEHAAADAEPGSAGESRTRGTERSARGSGPGSGAQEGSAADRPRKRGRSPSRRPSGRERHDEKITVYVSAEELMDLEHARLVLRGEHGLAVDRGRIVREAVAVVLADLETRGDASILVRRLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2B7</accession>
    <name>Q9S2B7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1713</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36735">
        <property type="entry name" value="T36735"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625986.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027935.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="GeneID" id="1097144"/>
    <dbReference type="KEGG" id="sco:SCO1713"/>
    <dbReference type="HOGENOM" id="CLU_3376258_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB50928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="34" mass="3285" checksum="F8DB6EC8B4EBB148" modified="2000-05-01" version="1">MSAPATLLRRLGGPAGAPGRTGDHGSPGRVGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2E8</accession>
    <name>Q9S2E8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2936</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36159">
        <property type="entry name" value="T36159"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627162.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975874.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2936"/>
    <dbReference type="GeneID" id="1098369"/>
    <dbReference type="KEGG" id="sco:SCO2936"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2994"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020861_2_0_11"/>
    <dbReference type="InParanoid" id="Q9S2E8"/>
    <dbReference type="OMA" id="HLKKQWA"/>
    <dbReference type="PhylomeDB" id="Q9S2E8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="598" mass="66194" checksum="B9716FE1536D1C0A" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2I6</accession>
    <name>Q9S2I6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2017</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35762">
        <property type="entry name" value="T35762"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626278.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028098.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2017"/>
    <dbReference type="GeneID" id="1097451"/>
    <dbReference type="KEGG" id="sco:SCO2017"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2047"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_11"/>
    <dbReference type="InParanoid" id="Q9S2I6"/>
    <dbReference type="OMA" id="PDCKQKG"/>
    <dbReference type="PhylomeDB" id="Q9S2I6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB52073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="452" mass="45993" checksum="9B6C33BA49E5ED9E" modified="2000-05-01" version="1">MGMPPLASGPHGADALRPLLDTVLDALRAGTAARGGPLPAGGPGAVAARVADAAGAILPERGDPEALRVLVTALAEGAADPAHPLCAAHLHTPPLAVAAAADLAASVLNPSLDSWDQAPAASALEALVTRALARETGAADAVVTTGGTESNQLAVLLARERHGAGLRLVHGAGAHHSLPRAAWLLGLPEPVVVPAPAGTLDPAALDEALTQVPGPHLVAATAGTTDAGLIDPLPEIADRCAAHGARLHVDAAYGAGLLFSERHRARLAGLEAADTVALDLHKLGWQPIPAGLLTVTDADDLGALHHRADYLNADDDTDAGLPDLLGRSPRTSRRPDVLKTAVTLKTLGRAGLGALVDAVCSLAREFADLVETHPGFELHAPPTISTVLFRPAGAGDDAVAAVRRALLTTGRAVLGRARADGRLWLKATLLNPHTRPDDLAALLTLVEGHVPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2K7</accession>
    <name>COAE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name type="ordered locus">SCO1996</name>
        <name type="ORF">SC7H2.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35741">
        <property type="entry name" value="T35741"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626257.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976822.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9S2K7"/>
    <dbReference type="SMR" id="Q9S2K7"/>
    <dbReference type="STRING" id="100226.SCO1996"/>
    <dbReference type="GeneID" id="1097430"/>
    <dbReference type="KEGG" id="sco:SCO1996"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2023"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_1_1_11"/>
    <dbReference type="InParanoid" id="Q9S2K7"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="PhylomeDB" id="Q9S2K7"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173010" description="Dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DPCK" evidence="1">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="200" mass="21501" checksum="FC2F5151EBEF33AE" modified="2000-05-01" version="1">MLRVGLTGGIGAGKSEVSRLLVEHGAVLIDADRIAREVVAPGTPGLAAVVAAFGEDVLAEDGSLDRPKLGSIVFADPEKLAVLNGIVHPLVRERSTALEEAAAEDAVVVHDVPLLTENGLAPLYDLVVVVDAAPATQLDRLMRLRGMTEQDARARMAAQATREQRREIADVVVDNDVPLEELRRRVEEVWDELVRGAHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2R4</accession>
    <name>Q9S2R4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2172</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35288">
        <property type="entry name" value="T35288"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626425.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976644.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2172"/>
    <dbReference type="GeneID" id="1097605"/>
    <dbReference type="KEGG" id="sco:SCO2172"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2209"/>
    <dbReference type="eggNOG" id="ENOG50339NW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190784_0_0_11"/>
    <dbReference type="OMA" id="WTWRFEK"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB51256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="82" mass="9051" checksum="C83D8726B3A2F3E1" modified="2000-05-01" version="1">MAAWTWRFETADGTEVQPAVQPEEFTTQGDAESWIGEQWKDLRAGGTDQVRLFEDSTEIYGPMSLHAEEAEADAEAEAGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2R6</accession>
    <name>Q9S2R6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2170</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35286">
        <property type="entry name" value="T35286"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626423.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028174.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2170"/>
    <dbReference type="GeneID" id="1097603"/>
    <dbReference type="KEGG" id="sco:SCO2170"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2207"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061533_1_0_11"/>
    <dbReference type="InParanoid" id="Q9S2R6"/>
    <dbReference type="OMA" id="WYGVRVF"/>
    <dbReference type="PhylomeDB" id="Q9S2R6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097697">
        <property type="term" value="F:tRNA 5-carboxymethoxyuridine methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="24725" checksum="616C51E822553893" modified="2000-05-01" version="1">MARQLDEQIAGRFAVGRRLRVLDVGMGQGTQALRLARAGHQVTGVERDATMIAAARDALAGQPEGIRERMRIVEGDGRDTGVHFLPGSFDVVLCHGVLMYVEEPDPLLAGLARMLAPGGLLSLVVRNGDALALRPGLHGDWPGALAAFDTTSYRNRLGLDVRADRLATLTAKLAGIGAPLHTWYGVRVFTDTAPDGAPPPADLDALLAAEERAGRTDPYRSVAALLHLCGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S6U3</accession>
    <name>Q9S6U3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO3892</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36579">
        <property type="entry name" value="T36579"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628078.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029295.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3892"/>
    <dbReference type="GeneID" id="1099328"/>
    <dbReference type="KEGG" id="sco:SCO3892"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3965"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_11"/>
    <dbReference type="InParanoid" id="Q9S6U3"/>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="PhylomeDB" id="Q9S6U3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="236" mass="25102" checksum="C9EDD3B3B76792D7" modified="2000-05-01" version="1">MAGGASHDGVSDQELLARHVEGDPDAFGELVRRHRDRLWAVALRTLGDREEAADAVQDALVSAYRAAHTFRGQAAVTTWLHRITVNACLDRARKAASRKTAPVDDTERLEQLLEPHESASAPAERNDLHRQLLEALGTLPADQRAALVLVDMQGYPVAEAARILDVPAGTIKSRCARGRARLLPLLTHLRPDGSGESRKPGPERNRTHGASVPPAAGPSEAGPGDSTAVKGGGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7N7</accession>
    <name>Q9X7N7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO6731</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB40681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35256">
        <property type="entry name" value="T35256"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630804.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031140.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6731"/>
    <dbReference type="GeneID" id="1102170"/>
    <dbReference type="KEGG" id="sco:SCO6731"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6838"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_11"/>
    <dbReference type="InParanoid" id="Q9X7N7"/>
    <dbReference type="OMA" id="DIIMGCV"/>
    <dbReference type="PhylomeDB" id="Q9X7N7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB40681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="404" mass="42247" checksum="6EC0E68097DF2C9D" modified="1999-11-01" version="1">MSTEAYVYDALRTPRGRGKANGALHGTKPVDLVVGLIQEIRARFPGLDPAAVDDIVLGVVGPVGDQGSDIARIAAIAAGLPDTVAGVQENRFCASGLEAVNMAAMKVRSGWEDLVLAGGVESMSRVPMASDGGAWFNDPMTNLATNFVPQGIGADLIATIEGFSRRDVDEYAALSQERAATAWKEGRFERSVVPVKDRAGLTVLDHDEHPRPGTTADSLAGLKPSFADIGELGGFDAVALQKYHWVERIDHVHHAGNSSGIVDGASLVAVGSEEVGDRYGLRPRARIVSAAVSGSEPTIMLTGPAPATRKALARAGLSIEDIDLVEINEAFAAVVLRFVKDMGLSLDKVNVNGGAIALGHPLGATGAMILGTLVDELERQDKRYGLATLCVGGGMGIATIVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7U3</accession>
    <name>Q9X7U3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative protease (Putative secreted protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7256</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35352">
        <property type="entry name" value="T35352"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631312.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031546.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7256"/>
    <dbReference type="ESTHER" id="strco-SC5H1.36">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1102694"/>
    <dbReference type="KEGG" id="sco:SCO7256"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7358"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013364_3_1_11"/>
    <dbReference type="InParanoid" id="Q9X7U3"/>
    <dbReference type="OMA" id="LMAINCA"/>
    <dbReference type="PhylomeDB" id="Q9X7U3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177003" evidence="1">
        <location>
            <begin position="33"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="105"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="543" mass="57697" checksum="D4E6549032B9F4B6" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Y5</accession>
    <name>Q9X7Y5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative long chain fatty acid coA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6790</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB39723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35430">
        <property type="entry name" value="T35430"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630862.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031185.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6790"/>
    <dbReference type="GeneID" id="1102229"/>
    <dbReference type="KEGG" id="sco:SCO6790"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6898"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_11"/>
    <dbReference type="InParanoid" id="Q9X7Y5"/>
    <dbReference type="OMA" id="RGMRKYD"/>
    <dbReference type="PhylomeDB" id="Q9X7Y5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="25"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB39723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="612" mass="66100" checksum="1195853270408094" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8K7</accession>
    <name>RL331_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L33 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmG1</name>
        <name type="ordered locus">SCO3428</name>
        <name type="ORF">SCE9.35c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36354">
        <property type="entry name" value="T36354"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975405.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8K7"/>
    <dbReference type="SMR" id="Q9X8K7"/>
    <dbReference type="STRING" id="100226.SCO3428"/>
    <dbReference type="GeneID" id="1098865"/>
    <dbReference type="KEGG" id="sco:SCO3428"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3490"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_1_11"/>
    <dbReference type="InParanoid" id="Q9X8K7"/>
    <dbReference type="OMA" id="GTGFYYT"/>
    <dbReference type="PhylomeDB" id="Q9X8K7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000170241" description="50S ribosomal protein L33 1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="54" mass="6416" checksum="FF887B3D13E57E3F" modified="1999-11-01" version="1">MARNELRPVIKLRSTAGTGYTYVTRKNRRNDPDRLVLRKYDPAAGRHVDFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8Q7</accession>
    <name>Q9X8Q7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component system regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO3640</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36530">
        <property type="entry name" value="T36530"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627834.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975298.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3640"/>
    <dbReference type="GeneID" id="1099076"/>
    <dbReference type="KEGG" id="sco:SCO3640"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3700"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="InParanoid" id="Q9X8Q7"/>
    <dbReference type="OMA" id="MVRQGFT"/>
    <dbReference type="PhylomeDB" id="Q9X8Q7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="24658" checksum="1030B1825BE04D34" modified="1999-11-01" version="1">MTTSSDGRVIRVLIADDQQMVRQGFTVLLNTQPDIEVIGQAVDGLDAVAKVAELAPEVVLMDIRMPELGGIEATRRITTATPEIRVLVLTTFDLDEYVYEALRAGASGFLLKDASADQLAEAVRVVAAGDALLAPGITRRLIAEFSRLDDRPRAPLKARVGELTERETEVLALIAQGLSNAEIAQRLVVAEQTVKTHVGRILVKLGLRDRTQAAVFAYESGLVRPAGY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-03-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8S2</accession>
    <name>SPEE2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyamine aminopropyltransferase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Putrescine aminopropyltransferase 2</fullName>
            <shortName evidence="1">PAPT 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spermidine synthase 2</fullName>
            <shortName evidence="1">SPDS 2</shortName>
            <shortName evidence="1">SPDSY 2</shortName>
            <ecNumber evidence="1">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">speE2</name>
        <name type="ordered locus">SCO3655</name>
        <name type="ORF">SCH10.33c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36545">
        <property type="entry name" value="T36545"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627849.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029148.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X8S2"/>
    <dbReference type="SMR" id="Q9X8S2"/>
    <dbReference type="STRING" id="100226.SCO3655"/>
    <dbReference type="GeneID" id="1099091"/>
    <dbReference type="KEGG" id="sco:SCO3655"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3716"/>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034289_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8S2"/>
    <dbReference type="OMA" id="AWTGDWG"/>
    <dbReference type="PhylomeDB" id="Q9X8S2"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000156509" description="Polyamine aminopropyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="1">
        <location>
            <begin position="247"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine synthase">
        <location>
            <begin position="235"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="389"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="554" mass="57759" checksum="593E484DCCD2DC42" modified="1999-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9Z2</accession>
    <name>CHPE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaplin-E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">chpE</name>
        <name type="ordered locus">SCO1800</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1714" last="1726">
            <title>A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Rink R."/>
                <person name="de Jong W."/>
                <person name="Siebring J."/>
                <person name="de Vreugd P."/>
                <person name="Boersma F.G."/>
                <person name="Dijkhuizen L."/>
                <person name="Wosten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="12832396"/>
            <dbReference type="DOI" id="10.1101/gad.264303"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Genes Dev." volume="17" first="1727" last="1740">
            <title>The chaplins: a family of hydrophobic cell-surface proteins involved in aerial mycelium formation in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Elliot M.A."/>
                <person name="Karoonuthaisiri N."/>
                <person name="Huang J."/>
                <person name="Bibb M.J."/>
                <person name="Cohen S.N."/>
                <person name="Kao C.M."/>
                <person name="Buttner M.J."/>
            </authorList>
            <dbReference type="PubMed" id="12832397"/>
            <dbReference type="DOI" id="10.1101/gad.264403"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>MASS SPECTROMETRY</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2004" name="Mol. Microbiol." volume="53" first="433" last="443">
            <title>The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins.</title>
            <authorList>
                <person name="Claessen D."/>
                <person name="Stokroos I."/>
                <person name="Deelstra H.J."/>
                <person name="Penninga N.A."/>
                <person name="Bormann C."/>
                <person name="Salas J.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Woesten H.A."/>
            </authorList>
            <dbReference type="PubMed" id="15228525"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2004.04143.x"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2007" name="Mol. Microbiol." volume="64" first="602" last="613">
            <title>SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Capstick D.S."/>
                <person name="Willey J.M."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="17462011"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2007.05674.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DEVELOPMENTAL STAGE</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2008" name="J. Bacteriol." volume="190" first="5879" last="5889">
            <title>Function and redundancy of the chaplin cell surface proteins in aerial hypha formation, rodlet assembly, and viability in Streptomyces coelicolor.</title>
            <authorList>
                <person name="Di Berardo C."/>
                <person name="Capstick D.S."/>
                <person name="Bibb M.J."/>
                <person name="Findlay K.C."/>
                <person name="Buttner M.J."/>
                <person name="Elliot M.A."/>
            </authorList>
            <dbReference type="PubMed" id="18586935"/>
            <dbReference type="DOI" id="10.1128/JB.00685-08"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CREATION OF A MINIMAL CHAPLIN STRAIN</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>A3(2) / M600</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="73" first="1128" last="1140">
            <title>Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose.</title>
            <authorList>
                <person name="de Jong W."/>
                <person name="Woesten H.A."/>
                <person name="Dijkhuizen L."/>
                <person name="Claessen D."/>
            </authorList>
            <dbReference type="PubMed" id="19682261"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2009.06838.x"/>
        </citation>
        <scope>FUNCTION IN GROWTH SUBSTRATE ATTACHMENT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="E18839" last="E18839">
            <title>The assembly of individual chaplin peptides from Streptomyces coelicolor into functional amyloid fibrils.</title>
            <authorList>
                <person name="Sawyer E.B."/>
                <person name="Claessen D."/>
                <person name="Haas M."/>
                <person name="Hurgobin B."/>
                <person name="Gras S.L."/>
            </authorList>
            <dbReference type="PubMed" id="21526199"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0018839"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2013" name="J. Struct. Biol." volume="184" first="301" last="309">
            <title>Chaplins of Streptomyces coelicolor self-assemble into two distinct functional amyloids.</title>
            <authorList>
                <person name="Bokhove M."/>
                <person name="Claessen D."/>
                <person name="de Jong W."/>
                <person name="Dijkhuizen L."/>
                <person name="Boekema E.J."/>
                <person name="Oostergetel G.T."/>
            </authorList>
            <dbReference type="PubMed" id="24012833"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2013.08.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>AMYLOID FORMATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2014" name="Appl. Microbiol. Biotechnol." volume="98" first="4491" last="4501">
            <title>Surface modification using interfacial assembly of the Streptomyces chaplin proteins.</title>
            <authorList>
                <person name="Ekkers D.M."/>
                <person name="Claessen D."/>
                <person name="Galli F."/>
                <person name="Stamhuis E."/>
            </authorList>
            <dbReference type="PubMed" id="24413917"/>
            <dbReference type="DOI" id="10.1007/s00253-013-5463-z"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2017" name="J. Struct. Biol." volume="198" first="82" last="91">
            <title>The pH-dependent assembly of chaplin E from Streptomyces coelicolor.</title>
            <authorList>
                <person name="Dokouhaki M."/>
                <person name="Hung A."/>
                <person name="Day L."/>
                <person name="Gras S.L."/>
            </authorList>
            <dbReference type="PubMed" id="28400129"/>
            <dbReference type="DOI" id="10.1016/j.jsb.2017.04.004"/>
        </citation>
        <scope>AMYLOID FORMATION</scope>
        <scope>DOMAIN</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 4 5 6 7 8 9">One of 8 partially redundant surface-active proteins required for efficient formation of aerial mycelium; the short chaplins assemble into a hydrophobic, amyloidal fibrillar surface layer that envelopes and protects aerial hyphae and spores, presumably anchored to the long chaplins (PubMed:12832396, PubMed:12832397, PubMed:15228525, PubMed:17462011). Chaplins have an overlapping function with the surface-active SapB peptide; chaplins are essential on minimal medium while on rich medium both chaplins and SapB are required for efficient aerial hyphae formation (PubMed:17462011). Chaplins are also involved in cell attachment to a hydrophobic surface (PubMed:19682261). Forms amyloid fibrils in vitro probably composed of stacked beta-sheets, at low extracellular concentrations individually restores the ability to form aerial hyphae to a chaplin-deficient strain, but does so less well than other short chaplins (PubMed:21526199). A small chaplin extract (ChpD, ChpE, ChpF, ChpG and ChpH) self-assembles into 2 different amyloids; small fibrils at the air-water interface form an amphipathic membrane that resembles spore-surface structures involved in aerial hyphae formation, and hydrophilic fibrils in solution that resemble the fibers that attach cells to a hydrophobic surface. At the air-water interface the hydrophilic surface is in contact with water (probably equivalent to the peptidoglycan layer), while the hydrophobic face is exposed to the air, making the surface of the aerial hyphae hydrophobic (PubMed:24012833). A minimal chaplin strain capable of forming aerial mycelium/hyphae on minimal medium contains ChpC, ChpE and ChpH. The strain also has restored rodlet formation on the hyphae surface. A second strain with ChpA, ChpD and ChpE makes slightly less robust hyphae. This essential chaplin may coordinate the assembly and/or polymerization of the other chaplins (PubMed:18586935). A small chaplin extract applied to a chaplin-deficient strain restores aerial hyphae formation (PubMed:12832396, PubMed:12832397). The small chaplin extract forms an amyloid-like structure similar to that seen on the surface of cells without rodlets (rdlA-rdlB deletions), and is highly surface active, reducing surface tension from 72 to 26 mJ/m(2), which probably allows escape of hyphae from an aqueous environment into air (PubMed:12832396).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3 5">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 3">Secreted</location>
            <location evidence="2 3">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Fimbrium</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2 5 13">Present in aerial hyphae of sporulating cultures (at protein level) (PubMed:12832396, PubMed:17462011). Strongest expression in spores, with weaker expression in aerial hyphae.</text>
    </comment>
    <comment type="induction">
        <text evidence="2 3 5">Highly expressed in 24 hour cultures while still submerged, during aerial hyphae formation on minimal medium, decreases once aerial growth ceases (PubMed:12832396). Strongly induced during aerial hyphae formation and sporulation on rich medium, under control of ECF sigma factor BldN; more strongly expressed when sporulation is blocked by deletion of whiB, whiD or whiH (PubMed:12832397). Expression depends on bldB but not bldA, bldD or bldH (at protein level) (PubMed:17462011).</text>
    </comment>
    <comment type="domain">
        <text evidence="11 14">The mature protein has a random coil structure at acidic pH, rapidly changing to beta-sheet as the pH rises (examined from pH 3.0 to 10.0); at pH 6.7 and higher forms amyloid fibrils visible by electron microscopy.</text>
    </comment>
    <comment type="mass spectrometry" mass="5279.0" method="MALDI" evidence="2"/>
    <comment type="mass spectrometry" mass="5271.65" method="MALDI" evidence="3"/>
    <comment type="disruption phenotype">
        <text evidence="2 4 5 6 7">Essential, it cannot be disrupted individually in a wild-type strain; the lethal effects of its disruption are suppressed by loss of some other chaplins, the roldet protein (RdlA and RdlB) or by inactivation of the tat secretion pathway (PubMed:18586935). Quintuple knockout chpA-chpB-chpC-chpD-chpH has strongly delayed aerial hyphae formation, makes many fewer aerial hyphae but no effect on viability of the spores produced. Further deletion of chpE leads to more severe effects, and on rich media few aerial hyphae are produced after prolonged growth. Those few hyphae do differentiate into spores and have a rodlet layer (PubMed:12832396). Deletion of all 8 chaplin genes on minimal medium leads to severely disrupted aerial hyphae that collapse on the colony surface and are not hydrophobic. A few spore chains can still be made, but they have neither rodlets or amyloid-like fibers. rdlA and rdlB mRNA are down-regulated (PubMed:15228525, PubMed:17462011). Deletion of all 8 chaplin genes on rich medium leads to a reduced abundance of aerial hyphae without rodlets and occasional spore chains on surface hyphae. A complete chaplin-negative plus ram-negative strain (deletion of ramR or the ramC-ramS-ramA-ramB operon) leads to the complete loss of robust aerial hyphae (PubMed:17462011). Deletion of all 8 chaplin genes significantly reduces cellular attachment to a hydrophobic substrate; thin fibrils instead of fimbrae are detected. The long chaplins (ChpA, ChpB and ChpC, as seen by near wild-type attachment of the hextuple chpA-chpB-chpC-chpD-chpE-chpH knockout) are not essential but may contribute to attachment (PubMed:19682261).</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="10">The small chaplin mixture (a cell wall extract of an rdlA-rdlB knockout) forms a stable coat on a number of surfaces (including Teflon and cotton) and emulsifies oil-water mixtures, which could be useful in medical and technical applications.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the chaplin family. Short chaplin subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="T36861"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626070.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977022.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X9Z2"/>
    <dbReference type="STRING" id="100226.SCO1800"/>
    <dbReference type="GeneID" id="1097234"/>
    <dbReference type="KEGG" id="sco:SCO1800"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1821"/>
    <dbReference type="eggNOG" id="ENOG50348JU">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_145456_3_1_11"/>
    <dbReference type="OMA" id="QAPIHIP"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0034">Amyloid</keyword>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0281">Fimbrium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2 3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004336130" description="Chaplin-E">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Chaplin" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01232"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="17462011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="18586935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="19682261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="24012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="10">
        <source>
            <dbReference type="PubMed" id="24413917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="11">
        <source>
            <dbReference type="PubMed" id="28400129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="12832396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="12832397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="21526199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="82" mass="7760" checksum="0400569E5A7E097C" modified="1999-11-01" version="1" precursor="true">MKNLKKAAAVTMVAGGLIAAGAGMASATDGGAHAHGKAVGSPGVASGNLVQAPIHIPVNAVGNSVNVIGVLNPAFGNLGVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAB8</accession>
    <name>Q9XAB8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1938</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="T36010"/>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
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    <dbReference type="PATRIC" id="fig|100226.15.peg.1965"/>
    <dbReference type="eggNOG" id="COG3429">
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        <property type="entry name" value="G6PDH_assembly_OpcA"/>
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    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB50763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="351" mass="37678" checksum="EE133DFBF2651577" modified="1999-11-01" version="1">MKTDLTDTTASKINKALVLGRRAIGTPAVGMVLTLVIVTDEENAYDALKAASDAAHEHPSRTLVVIKRVSRSPRDRTRSRLDAEVRLGADAGTGETIVLRLYGDVVDHAQSVVLPLLLPDAPVVVWWPVNAPLDPAKDPLGALAQRRVTDTYACEEPIRELAARADAYAPGDTDLSWTRITPWRSMLAAALDQVDCEVQSVEVEGEEFNPSCELLAMWLADRLDVPVRRTVSGGPGLTAVRMDTDCGPVVLDRADGSLANLSIQGQPSRAVALKRRETAELIAEELRRLDPDDTYASALRYGVDRLNESAKGDRVGEGDALAVAAPVGTVAKAPAKDAAREKTPVRKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAF9</accession>
    <name>Q9XAF9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5310</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB45614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35619">
        <property type="entry name" value="T35619"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629452.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030167.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100750"/>
    <dbReference type="KEGG" id="sco:SCO5310"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5396"/>
    <dbReference type="eggNOG" id="ENOG5030G9X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1562002_0_0_11"/>
    <dbReference type="OMA" id="QRASARW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB45614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="187" mass="19290" checksum="57A162509C4B97E2" modified="1999-11-01" version="1">MTASGPGGGDTPDGPDDAPVVPEYVWRLFLEDDERAIHASAPREPAARDRIPGRTRPEPPADCSGHPGRAHDTVGEPWRREDAWAGPAWRELDGRARLRRTGRVLGTAAAVALAVTAWSQLTTGPATPGGGPAETIGQRLEESPALPSPASVADTPASAESAGASPAAFEPAPSAIPRAPASTRTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9XAI7</accession>
    <name>Q9XAI7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ordered locus">SCO3615</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB45482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35383">
        <property type="entry name" value="T35383"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627810.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975324.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3615"/>
    <dbReference type="GeneID" id="1099051"/>
    <dbReference type="KEGG" id="sco:SCO3615"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3673"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_11"/>
    <dbReference type="InParanoid" id="Q9XAI7"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="PhylomeDB" id="Q9XAI7"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="270"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="352"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAB45482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="425" mass="44780" checksum="4A61177D9D128D15" modified="1999-11-01" version="1">MGLVVQKYGGSSVADAEGIKRVAKRIVEAKKNGNQVVAVVSAMGDTTDELIDLAEQVSPIPAGRELDMLLTAGERISMALLAMAIKNLGHEAQSFTGSQAGVITDSVHNKARIIDVTPGRIRTSVDEGNVAIVAGFQGVSQDSKDITTLGRGGSDTTAVALAAALDADVCEIYTDVDGVFTADPRVVPKAKKIDWISFEDMLELAASGSKVLLHRCVEYARRYNIPIHVRSSFSGLQGTWVSSEPIKQGEKHVEQALISGVAHDTSEAKVTVVGVPDKPGEAAAIFRAIADAQVNIDMVVQNVSAASTGLTDISFTLPKSEGRKAIDALEKNRPGIGFDSLRYDDQIGKISLVGAGMKSNPGVTADFFTALSDAGVNIELISTSEIRISVVTRKDDVNEAVRAVHTAFGLDSDSDEAVVYGGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4Y7</accession>
    <name>Q9Z4Y7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3244</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36192">
        <property type="entry name" value="T36192"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627456.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975569.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3244"/>
    <dbReference type="GeneID" id="1098678"/>
    <dbReference type="KEGG" id="sco:SCO3244"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3308"/>
    <dbReference type="eggNOG" id="ENOG5033WJS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1057331_0_0_11"/>
    <dbReference type="OMA" id="INAMAWA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030177066" evidence="1">
        <location>
            <begin position="38"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="265" mass="29652" checksum="DEC98836407D64E6" modified="1999-05-01" version="1">MSNHLDRRRLMTTALGGAAAVGLGAGAGLLGAAPAGAAERPVTPHRGHDDFPDVPGMLGDRRANELWYMFDETTLYNVGPELEQAFTDIETALGDGWERAIFDAWMAMAATSDYPNNFIEYVTPIKGPLQVLSKAQLGVFDTYYRPYGHGIVGAFADFAQGVLNDPRRERPVHTMNGNPPPGYHIWFIFMRSMMLLDISRHRWERMAPINAMAWAIQTIAKPSQFEVKEPLPRRVVAREAAKWLPRSVHRLDRDFLSYPLPEGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>O50492</accession>
    <name>O50492_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO5774</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35144">
        <property type="entry name" value="T35144"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629899.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030446.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5774"/>
    <dbReference type="GeneID" id="1101216"/>
    <dbReference type="KEGG" id="sco:SCO5774"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5864"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_3_11"/>
    <dbReference type="InParanoid" id="O50492"/>
    <dbReference type="OMA" id="IGRGQWQ"/>
    <dbReference type="PhylomeDB" id="O50492"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="68"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAA15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="299" mass="32006" checksum="CAB778CA79CD0338" modified="1998-06-01" version="1">MSSVLYDAQGPRAKRRNVVFTAVFVVVVLALLWWVYATLDEKGQLEWAKWQMFFTSDEPWSTYIWPGLQNTLKAAALSMVIALPLGAVLGIARLSDHAWVRIPVAIVVEFFRSIPVLVLMIFGLALFAEYTDVSSDDRPLYAVVTGLVLYNASVLAEIVRAGILALPKGQAEGAMAIGLRKGQSMRLILLPQAVTTMLPAIVSQLVVILKDTALGGAVLTFPELLASANTMSGYYGANVIASFTVVAVIYIALNFSLTTFASWLERRLRRAKKSTGAVLKADDAGIPGGAATGAGGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O69808</accession>
    <name>O69808_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28684">
        <property type="entry name" value="T28684"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630500.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972565.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6414"/>
    <dbReference type="GeneID" id="1101853"/>
    <dbReference type="KEGG" id="sco:SCO6414"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6514"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_4_0_11"/>
    <dbReference type="InParanoid" id="O69808"/>
    <dbReference type="OMA" id="AVKPNYS"/>
    <dbReference type="PhylomeDB" id="O69808"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA18901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="280" mass="31804" checksum="CEEE483E6E40B167" modified="1998-08-01" version="1">MSRVIRAALFQTAWTGDKESMIQVHEQAVRDAAAQGAQVMCFQELFYGPYFCQVQDPEFYAYAERVPDGPIVERFQRLAREHGIVLVLPMYEEEQPGVLYNTAAVIDADGSYLGKYRKTHIPQVRGFWEKFYFRPGNSGWPVFDTAVGKVGVYICYDRHFPEGWRALGLEGAEIVFNPSATSRGLSGYLWQLEQPAAAVANEYFVGAINRVGVEELGDNDFYGTSYFVDPEARFVGEVASDKETELVVRDLDMARLREVRDRWQFYRDRAPGAYSPLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O69816</accession>
    <accession>Q7BB68</accession>
    <name>O69816_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative two-component system regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ecrE2</name>
        <name evidence="6" type="ordered locus">SCO6422</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2001" name="Genes Dev." volume="15" first="3183" last="3192">
            <title>Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays.</title>
            <authorList>
                <person name="Huang J."/>
                <person name="Lih C.J."/>
                <person name="Pan K.H."/>
                <person name="Cohen S.N."/>
            </authorList>
            <dbReference type="PubMed" id="11731481"/>
            <dbReference type="DOI" id="10.1101/gad.943401"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">A3</strain>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF425994">
        <property type="protein sequence ID" value="AAM78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA18909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T28692">
        <property type="entry name" value="T28692"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630508.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972556.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="SMR" id="O69816"/>
    <dbReference type="STRING" id="100226.SCO6422"/>
    <dbReference type="GeneID" id="1101861"/>
    <dbReference type="KEGG" id="sco:SCO6422"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6522"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_11"/>
    <dbReference type="OMA" id="HISRAMT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAM78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAA18909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="224" mass="23676" checksum="BE5390A7F11384DC" modified="1998-08-01" version="1">MSGVLRVALVDDQALMRAGFRALLDAEEGVEVVGEAADGEQGVALVRAQVPDVALVDVQMPVMSGIEATRRIAADPALAAVRVVILTNYGLDEYVFEALRAGASGFLLKDTEPADLLQAIDVVAHGEALLSPSVTRTLIGEFVARPPDRSTAPGLDALTRREREVTALAARGLSNEEIAAHMVISPLTAKTHISRAMTKLGARDRAQLVVFAYESGLVAVRGRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O69890</accession>
    <name>Y5602_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>UPF0102 protein SCO5602</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5602</name>
        <name type="ORF">SC2E1.19</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34787">
        <property type="entry name" value="T34787"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629736.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030328.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O69890"/>
    <dbReference type="SMR" id="O69890"/>
    <dbReference type="STRING" id="100226.SCO5602"/>
    <dbReference type="GeneID" id="1101043"/>
    <dbReference type="KEGG" id="sco:SCO5602"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5694"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_3_11"/>
    <dbReference type="InParanoid" id="O69890"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="PhylomeDB" id="O69890"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167380" description="UPF0102 protein SCO5602">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="130" mass="13763" checksum="0AA47B38E1C839D0" modified="1998-08-01" version="1">MIVGAGGGADMNARGAMGRYGETLAARRLTGAGMTVLERNWRCGRTGEIDIVARDGDVLVVCEVKTRRGGAFEHPMAAVTPDKAERLRRLAERWIQTHGGAPPGGVRIDLVGVLLPQRGAPVVEHARGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-08-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O69908</accession>
    <name>O69908_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO5620</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34805">
        <property type="entry name" value="T34805"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629754.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030346.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5620"/>
    <dbReference type="GeneID" id="1101061"/>
    <dbReference type="KEGG" id="sco:SCO5620"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5709"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027861_0_0_11"/>
    <dbReference type="InParanoid" id="O69908"/>
    <dbReference type="OMA" id="YAETEWE"/>
    <dbReference type="PhylomeDB" id="O69908"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="8">
        <location>
            <begin position="184"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="452"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAA19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="796" mass="87396" checksum="C11407867FB2DB98" modified="1998-08-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O86520</accession>
    <name>O86520_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5538</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29068">
        <property type="entry name" value="T29068"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629672.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973458.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5538"/>
    <dbReference type="GeneID" id="1100978"/>
    <dbReference type="KEGG" id="sco:SCO5538"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5625"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074078_0_1_11"/>
    <dbReference type="InParanoid" id="O86520"/>
    <dbReference type="OMA" id="SGNWSYG"/>
    <dbReference type="PhylomeDB" id="O86520"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA19986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="190" mass="20047" checksum="DF541BF61BC0310B" modified="1998-11-01" version="1">MGTPPGGPSSGNWSYGPGQGQGDGSANGYGYPSVPNHRQPYAPQGPGPSPYDQPHAPRIQPVQPQRRTPEPAPAGASNNPLVRPYAMTGGRTRPRYQLAIEALVHTTAQPHQMQGQLPEHQRICNLCREIKSVAEISALLTIPLGVARILVADLAEAGLVAIHQPGGDESAGGQPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O86631</accession>
    <name>O86631_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6362</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T29456">
        <property type="entry name" value="T29456"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630454.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030859.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6362"/>
    <dbReference type="GeneID" id="1101803"/>
    <dbReference type="KEGG" id="sco:SCO6362"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6474"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_1_11"/>
    <dbReference type="InParanoid" id="O86631"/>
    <dbReference type="OMA" id="PQPGIRD"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="218"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAA20093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="429" mass="45049" checksum="F16AC90292F77695" modified="1998-11-01" version="1">MTSVTTDDISGMGPLVARLSRGGQRLRHADRAHPWVLDTGVVLVVLLMFCLPDLLRGSVGNGDAPRRFRLAFTELPVAGMLALQAGLVLPLLWRRRKPMAAFGVIAAVFALQWSLGAALRADVALFIALYSLALHGRLRQLPWAGAVMAGAMLLVAVRASSAVSVWDALFFLLSTATAALALGLMVRIRRAQLAGLRERAARLEIERDQRSRLATATERTRVAREMHDIVGHNLSVIITLADAGAYATDVAPERGKEALRLIGDTGRQALGELRRVLGVLREAGDGPAGGPELSPQPGIADIGALCATVRAAGLGVVYRTSGDVDALDGGVQLTVYRIVQEALTNTMKHAAGDARVHLAVVVTGARLSIRVQDTGPAARPGPPNEAGQGLVGMRERAALYGGTVSAGPTGGGGWSVEAVLDLTPQGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O86711</accession>
    <name>O86711_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6529</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA20626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35221">
        <property type="entry name" value="T35221"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630610.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030991.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6529"/>
    <dbReference type="GeneID" id="1101968"/>
    <dbReference type="KEGG" id="sco:SCO6529"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6632"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053995_1_0_11"/>
    <dbReference type="InParanoid" id="O86711"/>
    <dbReference type="OMA" id="PDHLWSA"/>
    <dbReference type="PhylomeDB" id="O86711"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="353" mass="38919" checksum="276531DE6B559A99" modified="1998-11-01" version="1">MQAAVTVTPARLPELLLGLATVRPVFLWGAPGIGKSSLVRNFADSLGLECVSLLGTQLAPEDLIGVPQIRDGRSVFCPPESIARDEPYCLFLDELNAATPDVQKAFYSLILDRRIGNYELPKGSLVIGAGNRATDNALARPIASALVNRLTHVHLDASAKDWLVWAGENGIHPWITDHLTDRPDHLWSKPPKTEEPFSTPRSWHMLSDALHSFGQDLDEETLKVLAHGTLTPAHATAFCGYVKIVRSRFGIEAILKGEARWPSRIEDRDLLYYLAESFRGRLVKELPASKEHMSANGRQTAYRAKSLLVQLAEISVEVAQSVIASDADGNPLLPAWFLVEAARDMPRLVEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O86744</accession>
    <name>O86744_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5655</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA19897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35443">
        <property type="entry name" value="T35443"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629785.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973370.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5655"/>
    <dbReference type="GeneID" id="1101094"/>
    <dbReference type="KEGG" id="sco:SCO5655"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5739"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_11"/>
    <dbReference type="InParanoid" id="O86744"/>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="PhylomeDB" id="O86744"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA19897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="457" mass="50474" checksum="D484377F334D3236" modified="1998-11-01" version="1">MSTDSPKDLSRTAYDHLWMHFTRMSSYENAPVPTIVRGEGTHIYDDKGRRYLDGLAGLFVVQAGHGRQELAETASKQAQELAFFPVWSYAHPKAVELAERLANEAPGDLNKVFFTTGGGEAVETAWKLAKQYFKLTGKPTKYKVISRAVAYHGTPQGALSITGLPALKAPFEPLVPGAHKVPNTNIYRAPIHGDDPEAYGRWAADQIEQQILFEGPETVAAVFLEPVQNAGGCFPPPPGYFQRVREICDQYDVLLVSDEVICAFGRLGTTFACDKFGYVPDMITCAKGMTSGYSPIGACVISDRLAEPFYKGDNTFLHGYTFGGHPVSAAVGIANLDLFEREGLNQHVLDNEGAFRATLEKLHDLPIVGDVRGNGFFYGIELVKDKATKESFDEEETERVLYGFLSKKLFENGLYCRADDRGDPVIQLAPPLISNQETFDEIEQILRATLTEAWTKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O86835</accession>
    <name>Y5738_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized zinc protease SCO5738</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5738</name>
        <name type="ORF">SC9A10.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">It is uncertain whether Met-1 or Val-35 is the initiator.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35838">
        <property type="entry name" value="T35838"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629863.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973289.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86835"/>
    <dbReference type="SMR" id="O86835"/>
    <dbReference type="STRING" id="100226.SCO5738"/>
    <dbReference type="GeneID" id="1101177"/>
    <dbReference type="KEGG" id="sco:SCO5738"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5826"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_3_11"/>
    <dbReference type="InParanoid" id="O86835"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="PhylomeDB" id="O86835"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000074428" description="Uncharacterized zinc protease SCO5738">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="459" mass="49671" checksum="8E9CFC166E11700F" modified="1998-11-01" version="1">MTSRSATATARTSSEARAVARTQTLIKGEHGIGTVRRTTLPGGLRIVTETLPSVRSATFGIWAHVGSRDETPALNGATHYLEHLLFKGTRKRSALDISSAIDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIQEEDVDVERGAILEEIAMTEDDPGDCVHDLFAHTMFGDNALGRPVLGTVDTVNALTADRIRRFYRKHYDPTHLVVAAAGNVDHNKVVRQVRAAFEKSGALKDPAAQPLAPRAGRRTVRAAGRVELIGRKTEQAHVILGMPGLARTDERRWAMGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPSQVHDVLKICRDELDHVAEHGLTDDEIGRAVGQLQGSTVLGLEDTGALMNRIGKSELCWGEQMSVDDMLARIASVTPDDVRAVARDVLGRRPSLSVIGPLKDKQASRLHDAVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-05" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O88018</accession>
    <name>TAL1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Transaldolase 1</fullName>
            <ecNumber>2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tal1</name>
        <name type="synonym">tal</name>
        <name type="ordered locus">SCO6662</name>
        <name type="ORF">SC5A7.12c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2"/>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA19941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35161">
        <property type="entry name" value="T35161"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630737.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031085.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O88018"/>
    <dbReference type="SMR" id="O88018"/>
    <dbReference type="STRING" id="100226.SCO6662"/>
    <dbReference type="GeneID" id="1102101"/>
    <dbReference type="KEGG" id="sco:SCO6662"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6768"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050771_1_0_11"/>
    <dbReference type="InParanoid" id="O88018"/>
    <dbReference type="OMA" id="RMMTTAD"/>
    <dbReference type="PhylomeDB" id="O88018"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173641" description="Transaldolase 1">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="381" mass="40407" checksum="44068BD43598F5B5" modified="1998-11-01" version="1">MITVTEATATAGALQRLADQGVSVWLDDLSRRRIESGNLAELIRTKNVVGVTTNPSIFQAAIGSGEGYEEQLADLATRGVTVDEAVRMMTTADVRAAADVLRGVYDASGGRDGRVSIEVDPRLAHDTAATVAEARQLSWLVDRPNVMIKIPATKAGLPAITEVIGAGISVNVTLIFSLERYREVMDAYLAGLEKAQAAGIDLAGIHSVASFFVSRVDSEIDKRLSLLGTEEALGLRGRAALANARLAYEAYENVFAGDRFTALAGARANAQRPLWASTGVKDPAFRDTLYVEELVAPGTVNTMPEATLDAAADHGDVRGDTVTGGYAQARADLAAVERLGVSYDEVVEQLEQEGVAKFEAAWQELLAAVTKSLDSKGVDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O88045</accession>
    <name>O88045_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1585</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36820">
        <property type="entry name" value="T36820"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625861.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027864.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1585"/>
    <dbReference type="GeneID" id="1097016"/>
    <dbReference type="KEGG" id="sco:SCO1585"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1597"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_6_0_11"/>
    <dbReference type="InParanoid" id="O88045"/>
    <dbReference type="OMA" id="APPATYW"/>
    <dbReference type="PhylomeDB" id="O88045"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAA20796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="206" mass="21975" checksum="CB29547082A9859C" modified="1998-11-01" version="1">MALRVTFVAAARSSPLLAERFDDERPLDQAGWNEALRAAGDLLPLAAAELRYCSPTPRSRATGDAIGCAPLSQLALRACDMGRWRGLTLGEAMAREPAAVDAWLADPRSAPHGGESLLGFITRVGGWLDTRPGEDGDRIVAVAEPSVIRAALVYALKAPPGTYWNLDVRPLSTTTVTGRAGRWSLRFEGTPDQGATRPAFRGGNPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-08" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O88054</accession>
    <name>SYFB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber>6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName>PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pheT</name>
        <name type="ordered locus">SCO1594</name>
        <name type="ORF">SCI35.16c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36829">
        <property type="entry name" value="T36829"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625870.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027870.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O88054"/>
    <dbReference type="SMR" id="O88054"/>
    <dbReference type="STRING" id="100226.SCO1594"/>
    <dbReference type="GeneID" id="1097025"/>
    <dbReference type="KEGG" id="sco:SCO1594"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1606"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_11"/>
    <dbReference type="InParanoid" id="O88054"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="PhylomeDB" id="O88054"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126960" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="B5">
        <location>
            <begin position="417"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB">
        <location>
            <begin position="745"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="840" mass="89985" checksum="88BF28BF42E1E03D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>P41103</accession>
    <name>RL10_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplJ</name>
        <name type="ordered locus">SCO4652</name>
        <name type="ORF">SCD82.23</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Mol. Microbiol." volume="12" first="375" last="385">
            <title>Synthesis of ribosomal proteins during growth of Streptomyces coelicolor.</title>
            <authorList>
                <person name="Blanco G."/>
                <person name="Rodicio R."/>
                <person name="Puglia A.M."/>
                <person name="Mendez C."/>
                <person name="Thompson C.J."/>
                <person name="Salas J.A."/>
            </authorList>
            <dbReference type="PubMed" id="7545948"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1994.tb01027.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="L24552">
        <property type="protein sequence ID" value="AAC36896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAB77426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S49536">
        <property type="entry name" value="S49536"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628813.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974311.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P41103"/>
    <dbReference type="SMR" id="P41103"/>
    <dbReference type="STRING" id="100226.SCO4652"/>
    <dbReference type="GeneID" id="1100093"/>
    <dbReference type="KEGG" id="sco:SCO4652"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4723"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_0_11"/>
    <dbReference type="InParanoid" id="P41103"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="PhylomeDB" id="P41103"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154719" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="176" mass="18646" checksum="30DAE36C9ADC16A6" modified="1995-02-01" version="1">MATPEKAAAVAELTDKFRSSNAAVLTEYRGLTVAQLKTLRRSLGENAQYAVVKNTLTKIAANEAGITLDDQLFAGPTAVAFVTGDPVESAKGLRDFAKDNPNLVIKGGVLDGKAMSADEIKKLADLESREVLLSKLAGAFKGKQSQTAQLFQALPSKLVRTVDALRAKQDEQGGAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>P54919</accession>
    <accession>Q9S2E6</accession>
    <name>HEM2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Delta-aminolevulinic acid dehydratase</fullName>
            <shortName>ALAD</shortName>
            <shortName>ALADH</shortName>
            <ecNumber>4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hemB</name>
        <name type="ordered locus">SCO3311</name>
        <name type="ORF">SCE68.09c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1995-01" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and characterisation of the genes that encode enzymes for first steps of tetrapyrrole biosynthesis in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Petricek M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>A3(2) / NRRL B-16638</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24"/>
    <dbReference type="EMBL" id="U19249">
        <property type="protein sequence ID" value="AAA61398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL939116">
        <property type="protein sequence ID" value="CAB45345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36259">
        <property type="entry name" value="T36259"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627521.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028903.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P54919"/>
    <dbReference type="SMR" id="P54919"/>
    <dbReference type="STRING" id="100226.SCO3311"/>
    <dbReference type="ChEMBL" id="CHEMBL3308959"/>
    <dbReference type="GeneID" id="1098745"/>
    <dbReference type="KEGG" id="sco:SCO3311"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3371"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_11"/>
    <dbReference type="InParanoid" id="P54919"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="PhylomeDB" id="P54919"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000140519" description="Delta-aminolevulinic acid dehydratase">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA61398." evidence="2" ref="1">
        <original>D</original>
        <variation>V</variation>
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="330" mass="35453" checksum="D2AF1F8B971F30F5" modified="2000-12-01" version="2">MTTYGSFPGARPRRLRTTPVMRRMVAETRLHPADFILPAFVREGVSEPVPIAAMPGVVQHTRDTLKKAAAEAVEAGVSGIMLFGVPEDGKKDAAGTAGTDPDGILQVALRDVRAEVGDELLVMSDLCLDEFTDHGHCGVLDGQGRVDNDATLERYAEMAQVQADAGAHVVGPSGMMDGQIGVIRDALDQIGREDVAILAYTAKYASAFYGPFREAVGSSLKGDRKTYQQDSANARESLRELALDLEEGADMVMVKPAGPYLDILAKVAEASDVPVAAYQISGEYSMIEAAAEKGWIDRDRAILESLTGIKRAGARNILTYWATEVARTLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-13" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>P58481</accession>
    <name>HTPG_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">SCO7516</name>
        <name type="ORF">SCBAC25F8.08</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631561.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971629.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P58481"/>
    <dbReference type="SMR" id="P58481"/>
    <dbReference type="STRING" id="100226.SCO7516"/>
    <dbReference type="PRIDE" id="P58481"/>
    <dbReference type="GeneID" id="1102954"/>
    <dbReference type="KEGG" id="sco:SCO7516"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7629"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_11"/>
    <dbReference type="InParanoid" id="P58481"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="PhylomeDB" id="P58481"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000063016" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="346"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="561"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="638" mass="71628" checksum="F7394CAB2931EB30" modified="2001-12-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKK6</accession>
    <name>Q7AKK6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4024</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628206.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029391.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4024"/>
    <dbReference type="GeneID" id="1099460"/>
    <dbReference type="KEGG" id="sco:SCO4024"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4087"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_2_11"/>
    <dbReference type="InParanoid" id="Q7AKK6"/>
    <dbReference type="OMA" id="RIPYPML"/>
    <dbReference type="PhylomeDB" id="Q7AKK6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAC32364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="507" mass="51633" checksum="5F275A1A19A7F4B2" modified="2012-05-16" version="1">MTTSPQESAEEREREPAPPVQGHPRRWLILGVISLAQLTVVLDNTVLNVAIPSLTDELGAATSDIQWMINAYSLVQSGLLLTAGSAADRYGRKKMLATGLALFGIGSLAAGLAETTGHLIAARAGMGVGGALLLTTTLAVVMQIFAPAEHAKAIGIWSAVSALGFACGPLIGGFMLDHFWWGAIFSINLPVVALGLVAVVTLVPESKNRQGDRPDLLGAVLSTVGMAALVYAIISGPGHGWTSGRVLATAAVAVGVLALFAHWESRVPYPMLDLTFFRDQRFTGAVAGLVLITFGMGGALFLLTQHLQFVLGYGPLEAGLRTAPLALTVVLLNFSGVAAKWLARLGTPMAVLLSMVLMAAGLVAIATLTGHGYAGTLLGLLLIGVGCALGNPAMAHALMSAIPPAKAGVGAGVNGTLAEFGNGLGVAVLGAVLTSRFAALAPVSATSLPAALASARGEGERRRVLDAFSSGVESSQLVGAVAVLLGGVVAAVLLRRAERADSGVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API1</accession>
    <name>Q7API1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mmyP</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639845.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039537.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095318"/>
    <dbReference type="KEGG" id="sco:SCP1.235"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8182"/>
    <dbReference type="HOGENOM" id="CLU_052657_1_2_11"/>
    <dbReference type="InParanoid" id="Q7API1"/>
    <dbReference type="OMA" id="HEPRAQV"/>
    <dbReference type="PhylomeDB" id="Q7API1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="232" mass="24992" checksum="C08F4218F0DEECD1" modified="2012-05-16" version="1">MPDVPRSAAFFDIDGTLTATTTMFDFLAHHLSLHGRPSEYAALHGRLRAMTEAGAGRADRCRAYYRVYAGVEERGLLAEGERWFLDRVRTPGFFHEPARAAFDAHAAAGDLTVLVSGSFDACLEPLAEHLGADVLLCSRPEVHDGRYTGALTTPMIGAAKAAAVSALVAERSLSLKDSHAYGDHVSDVPFMELVGHPVVVGRDPRMRCHARAHGWRCLEDSPLPGTAGGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q7API9</accession>
    <name>Q7API9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">23.ORF1</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639835.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039527.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095308"/>
    <dbReference type="KEGG" id="sco:SCP1.227c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8171"/>
    <dbReference type="HOGENOM" id="CLU_061176_0_0_11"/>
    <dbReference type="InParanoid" id="Q7API9"/>
    <dbReference type="OMA" id="TWFLGRA"/>
    <dbReference type="PhylomeDB" id="Q7API9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="25183" checksum="7F33C43645B5110B" modified="2012-05-16" version="1">MDEADHVADVEVLLRCPADADGSFGHTGEDGSPTKYGFQKAGGERAVTEAFGDEAVFLRPGVILGPGEYVGRLPWWLERAQRGGRVLAPAPEEQRIQPVDVRDVAAFAVRLAAGAGRGAFNVTHPDGISFGDFLAECLRVTGSDGAPVWVDPAVLTEHGVKQWTEVPLWRTHAGVWAVDSRRAVEAGLRCRPIADTVRDAWEWWAGEGRPVDHPRPAEHGIAAEKEARILASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJM6</accession>
    <name>Q8CJM6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6516</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAD55379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34746">
        <property type="entry name" value="T34746"/>
    </dbReference>
    <dbReference type="PIR" id="T35208">
        <property type="entry name" value="T35208"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733705.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030979.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6516"/>
    <dbReference type="GeneID" id="1101955"/>
    <dbReference type="KEGG" id="sco:SCO6516"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6619"/>
    <dbReference type="eggNOG" id="ENOG502ZIKJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133101_0_0_11"/>
    <dbReference type="OMA" id="MQRGSDR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="132" mass="14600" checksum="268C8046D1A21B21" modified="2003-03-01" version="1">MQRGSDRMSVHRDDEMKHELQGLLRSGHPTRSEEWNDPEPAAEDDPDVMYGPVTPGRGPTYLEALRLELARNLTRGSFPAGPRELTRTLRRGNAPDALVEGLDRLPHKARYDSVQELAVALTESGRSGSQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJS0</accession>
    <name>Q8CJS0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5239</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAD55345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733658.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973732.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5239"/>
    <dbReference type="GeneID" id="1100680"/>
    <dbReference type="KEGG" id="sco:SCO5239"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5323"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045351_1_0_11"/>
    <dbReference type="InParanoid" id="Q8CJS0"/>
    <dbReference type="OMA" id="GSIAIVH"/>
    <dbReference type="PhylomeDB" id="Q8CJS0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="293"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD55345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="491" mass="54176" checksum="66F8A92C890A3107" modified="2003-03-01" version="1">MPSMNELVRQHTALDDSDLEWLHLLVSEWQLLSDLSFADLVLWVPTRDGTRYVSVAQMRPNTGPTSYQDDMVGHLVPRGRRPMLDAALDEGRIVREGDPEWREEVPVRVESIPVRRQGRVLGVIARNTNLLTVRTPSRLELTYLQSASDLAQMIAAGAFPFENQQVDMDASPRVGDGLIRVDGDGIVQYASPNALSAYHRMGLAADLVGHHLGRTTAELAPSRGPVDEALAKVASGWAPREFEIEAHDGVIQFRAIPLKPKGTRIGSLVLLRDVTELRRRERELITKDATIREIHHRVKNNLQTVAALLRLQARRIESDRGREALEEAVRRVGSIAIVHETLSQNLDERVEFDEIADRVLAMVAEISPGKVTGRRTGRFGILDAEVATPLSMVLTEVLQNALEHGFRDGDTGTVEVSAVRGGTTKEARLLVTVQDDGVGLPEDFDPHRSGNLGLQIVRTLVEGELGGAFDMVQAAERGCRVILDIPVPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CJU0</accession>
    <name>Q8CJU0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4346</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAD55480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733634.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029592.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4346"/>
    <dbReference type="GeneID" id="1099786"/>
    <dbReference type="KEGG" id="sco:SCO4346"/>
    <dbReference type="eggNOG" id="ENOG50304IH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715552_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD55480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="369" mass="41517" checksum="742C2FDF7EF01830" modified="2003-03-01" version="1">MQRYGLKTELVDRLCNGPLEGVTDLEAAQALTRLVHTELENNGTGGGEKLKNEEMAEALRTLKFLLLRLKIDLKAPFDDFQSFRKYWIREGMGGGGGYAKRRSYLDGLFYPVREKLDEMEVTASSPTAYRGVDGEIKNIIFAPTGPTKPDIFLEDALSNIIKVANEDKCLVYNRPLTDAGLTWGDLMAWWTEKNGLEDASDYEVAQSLWLQLLESVPSSSPPARALFMTYCRRHISGGVVERNQPALLPEVYLHFDPLTKIQRGKLGKPRRLVRERMDFLLLLPGGVRIVIEVDGKHHYAREVPEASRNWKAAPDRYAEMVAEDRALRLKGYEVFRFGGKEIKENDASGLVGKFFDGLEARFGAKVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q8VWD3</accession>
    <name>Q8VWD3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP2.19c</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2 3">
        <name>SCP2</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="2">SCP2</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL645771">
        <property type="protein sequence ID" value="CAD12012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639781.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039593.1">
        <property type="nucleotide sequence ID" value="NC_003904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095062"/>
    <dbReference type="KEGG" id="sco:SCP2.19c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8314"/>
    <dbReference type="HOGENOM" id="CLU_1488209_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAD12012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="180" mass="19140" checksum="1283EEC3CD2E34BB" modified="2002-03-01" version="1">MTAPSVAVQAPERADTRPAPPASLEDRLTAVSALMDDRLTVAALAVAVNAAVSVPDVGPVDLADVVRVPADVQPYRPPVDLYPTPVAAVLQRARARLERDGWCQGATVDEDGARCLYGALHAEAASTGELHDALAVLLDAIRRHFPDEESVPAFNDGRHGSRVVFRVLDQAADLAHTRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-06-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IW5</accession>
    <name>Q93IW5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1305</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625591.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027709.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1305"/>
    <dbReference type="GeneID" id="1096728"/>
    <dbReference type="KEGG" id="sco:SCO1305"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1307"/>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038906_0_0_11"/>
    <dbReference type="InParanoid" id="Q93IW5"/>
    <dbReference type="OMA" id="AGVWVHE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005370585" evidence="2">
        <location>
            <begin position="16"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201_N" evidence="4">
        <location>
            <begin position="58"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="3">
        <location>
            <begin position="318"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="464" mass="50370" checksum="448407AE2C7A4145" modified="2001-12-01" version="1">MKPMRSAKPPKPPKPMKPMKPPKPMKPLNPTRQMNPTKPTPSPVTAEPDRVRVDLDKLFAARLQAARARPYLATALFALHVVTSRRVPTMAVDRYWRCYVSPVFVDRTPVEELAGVWVHEVSHLLRDHHGRSDRVARERGLTGPSERLRMNIAADCEINDDVFGDGLVRPEGAVDPAFLQLPEGQLMEEYLSLFRLGRLTEGLAWLDCGSGADGLDREWDLGPDGADGLSEQERDAVRFRVARGINAAPGSAPKGWRRWAEKVFHPPQPWRQLLGAAVRSATSSGGAGEDYTYGRPSRRSAGTPAVVLPSLRRRPPRVAVVVDTSGSVSDAELGSALLEVAAIARAVGGRRDLVSVVPCDAAARLAHSLCREEGIELVGGGGTDLRTGFAKALGARPAPDAVVVLTDGQTPWPDTRPACRTVVGLFPRERTGGSWNEDDPEYVPDAPPDWARVVVIQSGPDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q93IX5</accession>
    <name>Q93IX5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative AsnC-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1295</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625581.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977536.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1295"/>
    <dbReference type="GeneID" id="1096718"/>
    <dbReference type="KEGG" id="sco:SCO1295"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1296"/>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_0_3_11"/>
    <dbReference type="InParanoid" id="Q93IX5"/>
    <dbReference type="OMA" id="RLIFQQW"/>
    <dbReference type="PhylomeDB" id="Q93IX5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="163" mass="18218" checksum="FA85A72A3E43EF9E" modified="2001-12-01" version="1">MADSVVLDPVDLHLLRLLQNDARTTYRDLAAQVGVAPSTCLDRVTRLRRAGVILGHRLELDPAKLGRGLQALLLVQVRPHRRELVGPFVERIRALPESRTVFHLTGPDDYLVHVAVADMADLQRLVLDGFTSRREVARVETRLIFQQWECGPLLPPAVPADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J14</accession>
    <name>Q93J14_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3994</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628176.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029365.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3994"/>
    <dbReference type="GeneID" id="1099430"/>
    <dbReference type="KEGG" id="sco:SCO3994"/>
    <dbReference type="HOGENOM" id="CLU_2755989_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="70" mass="7637" checksum="485164A86AEFF72D" modified="2001-12-01" version="1">MLSHAGQPQDTPTDRRQRNEHLAVIVDTQTVSYVLKGSSIAGGDLSGFSVTSTVAHEFLRVRDVATREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J29</accession>
    <name>Q93J29_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC44702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628161.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3978"/>
    <dbReference type="GeneID" id="1099414"/>
    <dbReference type="KEGG" id="sco:SCO3978"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4052"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_11"/>
    <dbReference type="InParanoid" id="Q93J29"/>
    <dbReference type="OMA" id="VDWRIRE"/>
    <dbReference type="PhylomeDB" id="Q93J29"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="7"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="30380" checksum="DBA009923A817E60" modified="2001-12-01" version="1">MSFAEFGGPDVLQLVDAEEPHAGPGRIRIAVRAAGVNPVDWRVREGQVLGAHPVELPSGVGLDAAGVVDEVGEGVTGVEVGDRVFGEGADTYADFAVLGAWARMPEGLTFEEAAGYPSVVETALRVMREVGVRPGQTLLVSGASGGVGSAVLQIARERGVTVIGTAGAANQEYLRDLGAVATTYGEGWVERVRRHGEVHAALDLAGSGVIRELVELTGSPERVVSIADLGAPEFGVRFSGVAGSVPAALAEAVDLISRGKLHIPVEKSYSLAEAASAHIDSQAGHTRGRRVLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JE1</accession>
    <name>Q93JE1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5986</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630102.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973035.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5986"/>
    <dbReference type="ESTHER" id="strco-SCO5986">
        <property type="family name" value="Carbon-carbon_bond_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="1101428"/>
    <dbReference type="KEGG" id="sco:SCO5986"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6085"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_11"/>
    <dbReference type="InParanoid" id="Q93JE1"/>
    <dbReference type="OMA" id="CEAFDNY"/>
    <dbReference type="PhylomeDB" id="Q93JE1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC44600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="275" mass="30753" checksum="DA92ECA22BC417AA" modified="2001-12-01" version="1">MPDIELSAGTIEYEDTGGDGPVVVLLHGLVHDRTVWRKVLADLRTDHRVIAPTLPYGAHRRPMRRPPTPDLVNELIAEFLDRLDLTDVTLVENDCGRAQTVAARHPERLARLALVACEAFDNYPPGLPGKLIGIACRAPGGVSLLVRTLGLGPLRRLPVGIGALTKRPVPDEVVDGWLRPLRTDPAIRRDFRHYGTHVRREELLEAAQGLRRFDRPALVVWATEDLMMPRAHGRRLAELLPRGRLVEVEDTRTLIPEDQPELLASLLREFVAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RZ6</accession>
    <name>Q93RZ6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative IclR-family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO0574</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAC39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624887.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978288.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0574"/>
    <dbReference type="GeneID" id="1095997"/>
    <dbReference type="KEGG" id="sco:SCO0574"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.555"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_4_3_11"/>
    <dbReference type="InParanoid" id="Q93RZ6"/>
    <dbReference type="OMA" id="ELYPAHA"/>
    <dbReference type="PhylomeDB" id="Q93RZ6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="5">
        <location>
            <begin position="81"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="31018" checksum="581564576B380FAD" modified="2001-12-01" version="1">MAGRPVEPVDRRTPAGALQTVDRALLVLLAFERTRPDWGVTEIAAEFGWDTSVAQRLLSTLAGRGFLVSDPATRRYRIGPAALRLGRLWERSGSLELLAEPVLQELRAATGDTVLFCLPDSFHMRCVAAVEGEEGPLRYYPLVGELYPAHAGATSKSFYAFLPDEQRHRLFRGRPMARFTERTVTDPDQLEREFRTVRAQGYAWTVGEYDAGIGTVAMPVFLGSEPYGSLSLGAAKERFPEGPEDRLEVLRRAARLLEQRLTHPPQHHRRPRAPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QE3</accession>
    <name>Q99QE3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA integrase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCP1.19c</name>
        <name evidence="5" type="ordered locus">SCP1.335</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="5" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">A3</strain>
            <plasmid evidence="6">SCP1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639595.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639943.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039321.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095098"/>
    <dbReference type="GeneID" id="1095417"/>
    <dbReference type="KEGG" id="sco:SCP1.19c"/>
    <dbReference type="KEGG" id="sco:SCP1.335"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7965"/>
    <dbReference type="HOGENOM" id="CLU_056533_0_0_11"/>
    <dbReference type="OMA" id="AHHNPME"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="205"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC36860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="408" mass="45542" checksum="60BF5A078DD8EFEC" modified="2001-06-01" version="1">MSVIAVKESEVDLRHELMEGRAQLPRAGAVVETGEAHPPFMVVNGLGREVEPVTAYLRDLALSDSSPLTARSYGFGMLRWFRLLWLLDVAWERATEAETAVLTGWLRTAPNPQRHRRNPQSPPPGTVNPRTGKPYLGPGYAPTTINHALSVVSGFYAFHAHYGRGPVANPVPVSPQRRRALSHLSPLEPKPVLGRARLRQKVTGRPPRSIPDPLWDELFAAMGCERDRALLDCYVSSGARAEELLGVETGDIHWAKPGLYVITKGTRERELVPISPEACVRLARYLDSTGTPEAGEPVWRTRHGEDRPLTYWAMRRVVQRAQQNLRTNWTLHDLRHTAAHRMANGGKLTLPEVQAVLRHANIQTTSRYLAVRVEEIFDALLEHYNQPRPQVSYPTGYATDDIAAVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACP7</accession>
    <name>Q9ACP7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.271</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639881.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039573.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095354"/>
    <dbReference type="KEGG" id="sco:SCP1.271"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8215"/>
    <dbReference type="HOGENOM" id="CLU_055261_14_1_11"/>
    <dbReference type="OMA" id="FLRLACC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="53" mass="6269" checksum="DD864841B0B25EBC" modified="2001-06-01" version="1">MGKFRYVVEQTSALLHHFKRLAVRWKRGLELHNAFLSLASSLICWRRLRKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACQ8</accession>
    <name>Q9ACQ8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.260</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639870.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039562.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095343"/>
    <dbReference type="KEGG" id="sco:SCP1.260"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8203"/>
    <dbReference type="HOGENOM" id="CLU_2095411_0_0_11"/>
    <dbReference type="OMA" id="CSRWIAR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="116" mass="13095" checksum="2CBE6C6DFF0D45B4" modified="2001-06-01" version="1">MAAHSRQVLLDLVRWNGRIDDLIAAARRIPEGEFPGVVMDRASAQAALRKVLAGQALPGDLTAWTEQLHMREDIDIEPGHEDLLTQFLFEMSTPELFEPITRELCSRWLDELCATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACT5</accession>
    <name>Q9ACT5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.217</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639824.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039516.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095296"/>
    <dbReference type="KEGG" id="sco:SCP1.217"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8158"/>
    <dbReference type="HOGENOM" id="CLU_2773988_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="7538" checksum="1020CD6B7718E375" modified="2001-06-01" version="1">MDNSVERTAAELAELIGVPAPHFSRARRELEAAGYLECTHTMGQVKFFRLGEAASARQVVVPLLNRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACT8</accession>
    <name>Q9ACT8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.215</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639821.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039513.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095293"/>
    <dbReference type="KEGG" id="sco:SCP1.215"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8155"/>
    <dbReference type="HOGENOM" id="CLU_055261_9_2_11"/>
    <dbReference type="InParanoid" id="Q9ACT8"/>
    <dbReference type="OMA" id="VADIECA"/>
    <dbReference type="PhylomeDB" id="Q9ACT8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="17548" checksum="955AFAC3DC7E505C" modified="2001-06-01" version="1">MTTKVHLACDGRGLPLAVAVTPGNVNDSTVFDAVLNAVRVPRAGVGRPRRRPDVVIADKAYSSRAIRQRLRRRGIRAVIPERTDQKANRTRRGRTGGRPPAFDRDLYKARNVVERCFNRLKQFRAVATRFDKLAARYRAGLHLAALILWLRKPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACW1</accession>
    <name>Q9ACW1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative integrase/recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCP1.190c</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="6">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639780.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039489.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095269"/>
    <dbReference type="KEGG" id="sco:SCP1.190c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8132"/>
    <dbReference type="HOGENOM" id="CLU_1004406_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAC36712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="277" mass="30289" checksum="EFD6C31761E2FD78" modified="2001-06-01" version="1">MPTVVQLPAGKALTVRAAADAFLDSLRNPNTVRSYSTGIGKTAERIGEARPLGSVADDEIGEALELLWGEAAVNTWNARRAAVLSWLGWCEEYGYDGPSVPAWTKRLAVPDSETPARSKMAVDRLIARREVHLREKTLWRMLYETAGRAEEILSVNIEDLDLAARRCPVKAKGARSKARRRGQAREDFVLETVYWDAGTARLLPRLLKGVPAARCSSPTAARPGEGRQPARRVPGHWPGPPLLRSGPCAAGRAHCRARAGNRLGPARVPPFRSDPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACX0</accession>
    <name>Q9ACX0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hypoth_Ymh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.182</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639763.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039480.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095260"/>
    <dbReference type="KEGG" id="sco:SCP1.182"/>
    <dbReference type="HOGENOM" id="CLU_1106593_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012654">
        <property type="entry name" value="CHP02391"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09509">
        <property type="entry name" value="Hypoth_Ymh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02391">
        <property type="entry name" value="hypoth_ymh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypoth_Ymh" evidence="1">
        <location>
            <begin position="118"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="251" mass="27131" checksum="955F25AAB27EE9D2" modified="2001-06-01" version="1">MTFTYHAPVPAQQIRELPIRDVALLLLQHLARGNGRALQLNSIVGSTAARAYEGEPDIDALLDVLTDAWSWLESRALLARDRNQTEAFRRVSREGVKLAKNPTGLAQFEAGERLSGPLHPALEGPVRTNFHLGEYELASFAAMKAVEVAVREASGLDNSLVGVHLMRAAFQPHKNGKVGGPLADAEAEGGEQEAASALFAGAMGAYKNPPSHRTVKFDDPIEAAEIIQFADLLLRQVDRAKQRAQSPPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACY3</accession>
    <name>Q9ACY3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.168</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639741.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039467.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095246"/>
    <dbReference type="KEGG" id="sco:SCP1.168"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8114"/>
    <dbReference type="HOGENOM" id="CLU_060965_1_0_11"/>
    <dbReference type="OMA" id="GDPPYDV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323521" evidence="1">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="292" mass="30670" checksum="018C85FA0C084B85" modified="2001-06-01" version="1">MPVTALISAKSCGVTATALALTLSSKHSSLLAECDPAGGIIRAGLLSGQVNAGVGLYHLARAERTGPEALANAFASHLWHLDQAGHRKLLPGLTDPAQASALARTWPTLADVLHVMSQQAGHDIYIDGGRLALEAGHLHPALTPAPLLYRADLVLLVVRGTEQSLALARHVIPSLRTALHENGSGADALGLLLIEEGDFRSHQVSTSLGTPVIAALPYAPDVAHYLTAGGRPPRGYGRSPLLRHARTASEQIEAAANRRQLQQQYAPPPSAPHLAGILQRLNQRSEGGVKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD41</accession>
    <name>Q9AD41_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCP1.109</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639682.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039408.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095187"/>
    <dbReference type="KEGG" id="sco:SCP1.109"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8058"/>
    <dbReference type="HOGENOM" id="CLU_2883827_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC36630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="6593" checksum="44DF7A1BA0FBD516" modified="2001-06-01" version="1">MTSTEQVATLSTFGSVWAVLAVGRSLADHVFGQSAHQAANKGGAVGMRLHLTTSTLHQQGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD86</accession>
    <name>Q9AD86_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4909</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAD30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629062.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029940.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4909"/>
    <dbReference type="GeneID" id="1100350"/>
    <dbReference type="KEGG" id="sco:SCO4909"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4988"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080170_0_0_11"/>
    <dbReference type="InParanoid" id="Q9AD86"/>
    <dbReference type="OMA" id="ALGAHPC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAD30900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="27980" checksum="256B03878FFDA53E" modified="2001-06-01" version="1">MWIATDCPDNSAHRDQVTAQRDRDVTHAAKCTRGVVRRPSDASDWSPVSSHPPIPTRVVLLCGPSGSGKSLLAAHSGLPVLRLDDFYKEGTDPTLPTVPLSSDIDWDHPASWDADAAVAAIGELCRTGRTGVPVYDISLSARTGEETVDIGRTPLFLAEGIFAAELVDRCRELGVLADALCLSRGPLTTFRRRFLRDLREGRKSVPFLLRRGWRLMRLERSVIARQTALGAHACDRDEAMGRLAAAAAGRCATSRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-05-25" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ADD9</accession>
    <name>Q9ADD9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative tetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2007-09" db="PDB data bank">
            <title>Crystal structure of tetR-family transcriptional regulator.</title>
            <authorList>
                <person name="Dong A."/>
                <person name="Xu X."/>
                <person name="Gu J."/>
                <person name="Edwards A.M."/>
                <person name="Joachimiak A."/>
                <person name="Savchenko A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC37456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629219.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030034.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="PDB" id="2REK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.86 A"/>
        <property type="chains" value="A/B=1-199"/>
    </dbReference>
    <dbReference type="PDBsum" id="2REK"/>
    <dbReference type="SMR" id="Q9ADD9"/>
    <dbReference type="STRING" id="100226.SCO5068"/>
    <dbReference type="GeneID" id="1100509"/>
    <dbReference type="KEGG" id="sco:SCO5068"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5147"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_17_1_11"/>
    <dbReference type="InParanoid" id="Q9ADD9"/>
    <dbReference type="OMA" id="HSCGNRI"/>
    <dbReference type="PhylomeDB" id="Q9ADD9"/>
    <dbReference type="EvolutionaryTrace" id="Q9ADD9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC37456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2REK"/>
        </source>
    </evidence>
    <sequence length="199" mass="20887" checksum="443BAD3163523DA0" modified="2001-06-01" version="1">MSWENPGPPKRADARRNYDRIIEAAAAEVARHGADASLEEIARRAGVGSATLHRHFPSRWGLLQAVFQERVAQLCDEARSLAAEHPPATALTRWLTSLAVFGAVTRGAARSLLPATGTNTGAALDSRCEQLLTEAGADLLARAQEDGTVRDDVTALELLSLANAVSLAAEHTPDAAHHATRLMGIALGGLGAPGPRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWM6</accession>
    <name>Q9EWM6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7763</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631796.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031890.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7763"/>
    <dbReference type="GeneID" id="1103200"/>
    <dbReference type="KEGG" id="sco:SCO7763"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7882"/>
    <dbReference type="eggNOG" id="COG1787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072803_1_0_11"/>
    <dbReference type="OMA" id="AGWHIET"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015666">
        <property type="term" value="F:restriction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="233" mass="26026" checksum="03152C2418386986" modified="2001-03-01" version="1">MTRRRSPVRLRTRRSSRRQQQRDARLIAFAVVAAAGIGLAVMVVNWLLVHWWVLVVVLVLAVLAGAGWLYNRQQRVQWEAVRAQGLRYGLPQLDALHHTRFEDAIRELMRRDGCRDAQRVGGRGDLGADVKATDPYGRRWVIQCKHRRAGARGSAVGTPDLQVLNGTARQVHGADVAVIVTNGRVTGPAVTFAKQQRLHVVDRQTLAVWASGSRPLWELLRAVPPPRRPSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWN3</accession>
    <name>Q9EWN3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative anti-sigma factor antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7754</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631789.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031884.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7754"/>
    <dbReference type="GeneID" id="1103192"/>
    <dbReference type="KEGG" id="sco:SCO7754"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7876"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_2_11"/>
    <dbReference type="OMA" id="AVETHPM"/>
    <dbReference type="PhylomeDB" id="Q9EWN3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="127" mass="13440" checksum="EE86282EEE1CEC9E" modified="2001-03-01" version="1">MSLHKAVTGCTDAADVSRPQGLDQASVVLYERCGVPVVGVCGEYDLHSITPLSQALGTAAREHTKVVLEASGITFADSALLNLLILTQRSVDLRVAAPARQLRRLLEITGVDAVLKVRSTVEEAATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2L8</accession>
    <name>Q9F2L8_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TerD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3763</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAC10301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627953.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029219.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3763"/>
    <dbReference type="GeneID" id="1099199"/>
    <dbReference type="KEGG" id="sco:SCO3763"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3822"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399489_0_0_11"/>
    <dbReference type="OMA" id="DMGRHWV"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC10301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="694" mass="74941" checksum="29941B3182F3E0BF" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2W9</accession>
    <name>Q9F2W9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO4592</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628754.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029749.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4592"/>
    <dbReference type="GeneID" id="1100032"/>
    <dbReference type="KEGG" id="sco:SCO4592"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4664"/>
    <dbReference type="eggNOG" id="COG2962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054508_1_0_11"/>
    <dbReference type="InParanoid" id="Q9F2W9"/>
    <dbReference type="OMA" id="HRMVWSL"/>
    <dbReference type="PhylomeDB" id="Q9F2W9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="157"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="362" mass="38566" checksum="914042CBED0CA322" modified="2001-03-01" version="1">MAGSSRSDQRVGLLNGFAAYGMWGLVPLFWPLLKPAGAGEILAHRMVWSLAFVAVALLFVRRWAWAGELLRQPRRLALVAVAAAVITVNWGVYIWAVNSGHVVEASLGYFINPLVTIAMGVLLLKERLRPAQWAAVGTGFAAVLVLAVGYGQPPWISLCLAFSFATYGLVKKKVNLGGVESLAAETAIQFLPALGYLLWLGAQGESTFTTEGAGHSALLAATGVVTAIPLVCFGAAAIRVPLSTLGLLQYLAPVFQFLLGVLYFGEAMPPERWAGFGLVWLALTLLTWDALRTARRTARALREQLDRSGAGVPPLKGAAAAREPRVVASGTPAPGAGDAPQQQQQQQQQQQQQQHGTRAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3D7</accession>
    <name>Q9F3D7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7620</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631661.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971524.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7620"/>
    <dbReference type="GeneID" id="1103058"/>
    <dbReference type="KEGG" id="sco:SCO7620"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7738"/>
    <dbReference type="eggNOG" id="COG3189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_11"/>
    <dbReference type="InParanoid" id="Q9F3D7"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="PhylomeDB" id="Q9F3D7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="119" mass="13823" checksum="12F71AB1FAC09F66" modified="2001-03-01" version="1">MTARVGYRRIYESATPQDGKRVLVDRLWPRGVSKEKAGLDAWLRDVAPSADLRRWYHHDPRRYDEFRRRYFAELEDSDHEAALERLRDLAARAKVTLLTATKDVDHSEAAALAEWLDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3L3</accession>
    <name>Q9F3L3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5251</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAC05968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629397.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973719.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5251"/>
    <dbReference type="GeneID" id="1100692"/>
    <dbReference type="KEGG" id="sco:SCO5251"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5336"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_0_11"/>
    <dbReference type="InParanoid" id="Q9F3L3"/>
    <dbReference type="OMA" id="MWPMWRE"/>
    <dbReference type="PhylomeDB" id="Q9F3L3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC05968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="212" mass="23028" checksum="EB6B8E7A72F9014B" modified="2001-03-01" version="1">MGVVIRTAGEDDRELVVRLLDEAFQDDPVSSWVFPGTEYRRRTHHRLMAAFADAVLADGRVDLTEDGAACALWLPVPAGEPAGDGPGAEQGSESGEGAEDGPARIRAAVDPENERVELIARLTDGIHPSGRAHAYLWMIGVVPERQGEGLGTALIGTVLDRCDREGLPAYLEASSARGKALYERLGFEFTGRALDLPDGPRMWPMWREPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBK9</accession>
    <name>Q9FBK9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5149</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC01350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629297.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030085.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5149"/>
    <dbReference type="GeneID" id="1100590"/>
    <dbReference type="KEGG" id="sco:SCO5149"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5232"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_3_7_11"/>
    <dbReference type="InParanoid" id="Q9FBK9"/>
    <dbReference type="OMA" id="RTATGPW"/>
    <dbReference type="PhylomeDB" id="Q9FBK9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="438"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC01350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="542" mass="53761" checksum="620F7D889DF7212D" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCC0</accession>
    <name>Q9FCC0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO1247</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625535.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027667.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1247"/>
    <dbReference type="GeneID" id="1096670"/>
    <dbReference type="KEGG" id="sco:SCO1247"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1247"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_7_4_11"/>
    <dbReference type="InParanoid" id="Q9FCC0"/>
    <dbReference type="OMA" id="TWTLCSI"/>
    <dbReference type="PhylomeDB" id="Q9FCC0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="225" mass="24481" checksum="40B4875428197B05" modified="2001-03-01" version="1">MPLRSVRTRGVPRDTVHHPLFARYYARVSVSAETRMGMARVRRRLLAGLSGRVIEVGAGNGLNFSHYPGTVSEVVAIEPERVLRQLAVEAALRAEVPVDVAPGAAEALPVKSEAFDAAVVSLVLCSVRDVPRALAELRRVLRPGGQVRFFEHGRGGGRAMTFTQRALDRTLWPPLAGGCHLSREPVAALREAGFTLGPYRQVMMPEHGPALPSSYCVLGTAWRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCF2</accession>
    <name>Q9FCF2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small hydrophilic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4218</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628393.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974757.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4218"/>
    <dbReference type="GeneID" id="1099658"/>
    <dbReference type="KEGG" id="sco:SCO4218"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4281"/>
    <dbReference type="eggNOG" id="ENOG5031WUM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192330_0_1_11"/>
    <dbReference type="OMA" id="MEAGDIY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045961">
        <property type="entry name" value="DUF6381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19908">
        <property type="entry name" value="DUF6381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="63" mass="7152" checksum="7B21446D36B6E7C5" modified="2001-03-01" version="1">MSAGGEARARLQQMRDKAQELKAASERTSDPDERKRLQEKARRLQSQSEEESMERGGDIYPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCM3</accession>
    <name>Q9FCM3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7791a</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC04103.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631822.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031915.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7791a"/>
    <dbReference type="GeneID" id="1103229"/>
    <dbReference type="KEGG" id="sco:SCO7791a"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7908"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FCM3"/>
    <dbReference type="OMA" id="EDYLANW"/>
    <dbReference type="PhylomeDB" id="Q9FCM3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04103.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="409" mass="44455" checksum="D99259A26C6E2D9F" modified="2002-10-01" version="2">MQKRALVVGLGIAGMSAAIGLRQAGWTPVIVERAPERRTGGYFIFMFPEGVRAAADLGIADHLHTRNPEWRPGGNSWSVDRRGRRKPALGLLDAPSGLAAVLRSDIEAALWQGITGDGTEDAVEVRFATTPVEITEGAGGVRVLLEDAGTGKQYLEEFDLVVGADGMRSSVRRMVFGPDEDYLANWKAMICAFQMKEQVPTYEASDSIIVSRPKRAMWVFGLADHAPCAWLTYRTDDIPDRFAGPSIEQVRAAFSGIEDDPVVRHVLDSLEQAPDHVFDSIHQVKMDRWSTGRVVLVGDAAWCMNTYSAMGSSSSLRGGAALGAALREHPDDLAAALDAWEAGLRPYITSQRRSARIKQQRFVPSSRPVQVLVSGVLDLVRRVVHRRLAAEFTAAAAPTAAAVPSGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J2</accession>
    <name>Q9K3J2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Betaine aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO4828</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628984.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029892.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4828"/>
    <dbReference type="GeneID" id="1100269"/>
    <dbReference type="KEGG" id="sco:SCO4828"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4904"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_11"/>
    <dbReference type="InParanoid" id="Q9K3J2"/>
    <dbReference type="OMA" id="VTGPGHT"/>
    <dbReference type="PhylomeDB" id="Q9K3J2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB97431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="509" mass="54296" checksum="2FE64FD62E119A1F" modified="2000-10-01" version="1">MANSTHTPAERAHRTIHAGGEWLAASSGATREILDPADAVAFAVVAEGDEKDTDLAVAAARRAFDAGDWPHTPVAERAALLRRVAGLLVRDREKLGLLESRDAGKTVEEGRVDIDCVADAFRYFADLVAGEAPGRVVDAGSPEVHSVVVHEPVGVCAMITPWNYPLLQASWKIAPALAAGNTFVIKPSEITPMTTIALIDLLVEAGLPTGVANIVTGPGHTVGARLAEHPDVDLVSFTGGLTSGVKVAQAAAVTVKKVALELGGKNPNVVFADACATEEGFDTAVDQALNAAFMHSGQVCSAGGRLIVEESVRERFVAELARRAERIRLGRGTEEGVECGPLVSAQQRAKTEDYVASALAEGAELRCGGKRPEPSPQRPESGYFYEPTVLDHCHREMRVVREEVFGPVLTVETFRTEDEAVALANDTEYGLAGAVWTADAGRARRVAGRLRHGTVWINDFHPYLPQAEWGGFGKSGVGRELGPAGLAEYRESKHVYQNLAPKPVRWFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3J8</accession>
    <name>Q9K3J8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4822</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB97425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628978.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974149.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4822"/>
    <dbReference type="GeneID" id="1100263"/>
    <dbReference type="KEGG" id="sco:SCO4822"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4899"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108944_0_0_11"/>
    <dbReference type="OMA" id="RVCSIVY"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB97425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="195" mass="20714" checksum="74261D82EA38324A" modified="2000-10-01" version="1">MSFGDPNNPYGPPQGGQQPNYGYPQQPQGQPGYGYPAAPPVQQPYGGGYGPGPTEMPGITRAAQIMLAVIAAAHLIVAAVYAYNLSQWDEVMLEAGVSGDAEAERFLELGKGIVVFFLALAAVYAVLGLVLVLQYAKGSNAVRVCSIVYGSLAIVTGIFTLAIYGLGLLIMIVSILLIVFAAKRASAEWFRRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3X9</accession>
    <name>Q9K3X9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative secreted serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO1355</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-6404777">
            <id>Q9K3X9</id>
        </interactant>
        <interactant intactId="EBI-6404783">
            <id>P61152</id>
            <label>sti1</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625640.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027742.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="IntAct" id="Q9K3X9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1355"/>
    <dbReference type="MEROPS" id="S08.051"/>
    <dbReference type="GeneID" id="1096778"/>
    <dbReference type="KEGG" id="sco:SCO1355"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1363"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_11"/>
    <dbReference type="InParanoid" id="Q9K3X9"/>
    <dbReference type="OMA" id="ATSWSNY"/>
    <dbReference type="PhylomeDB" id="Q9K3X9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P_dom"/>
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        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
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        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
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        <property type="entry name" value="S8pro/Inhibitor_I9"/>
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        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
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        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P_proprotein"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILISIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB95812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="537" mass="55371" checksum="0F5DD8D4D6F55659" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK8</accession>
    <name>Q9KXK8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2312</name>
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    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="P:chondroitin sulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:DIM/DIP cell wall layer assembly"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB93432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="238" mass="25290" checksum="1F6E4418D8E78521" modified="2000-10-01" version="1">MGHTRYDHRKALMTAAPASTPAPSQEVLAAFEAAKGFMPAHEGRALYAAAVEAGGLGLPLLEVGTYCGRSTVLLADAARRAGVTALTVDHHRGSEEQQPGWDYHDPGTVDPELGVMDTLPTFRRTLHRAGLEEHVVALVGRSPQVAAVWNSPLGLVFVDGGHTDEHANADYEGWAPHVADGGLLVIHDVFPDPADEFTGQAPYRVYLRALASGAFTEVSATDSLRVLRRTGAGIRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="160" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXM5</accession>
    <name>Q9KXM5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">SCO4332</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB93406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029584.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4332"/>
    <dbReference type="TCDB" id="3.A.3.23.1">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1099772"/>
    <dbReference type="KEGG" id="sco:SCO4332"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4402"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_5_1_11"/>
    <dbReference type="InParanoid" id="Q9KXM5"/>
    <dbReference type="OMA" id="RLGRKQC"/>
    <dbReference type="PhylomeDB" id="Q9KXM5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAB93406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="802" mass="85178" checksum="0C8BC48FE22D10E1" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KYY3</accession>
    <name>Q9KYY3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7546</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAB90904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631590.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031739.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7546"/>
    <dbReference type="GeneID" id="1102984"/>
    <dbReference type="KEGG" id="sco:SCO7546"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7660"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_3_0_11"/>
    <dbReference type="InParanoid" id="Q9KYY3"/>
    <dbReference type="OMA" id="GCTMTNM"/>
    <dbReference type="PhylomeDB" id="Q9KYY3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176778" evidence="2">
        <location>
            <begin position="33"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB90904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="340" mass="35944" checksum="2A76124E19F0BB87" modified="2000-10-01" version="1">MTRKGPTAMSPVLTRRSLTTTLAGVAAMVLLAACGGSSSGGSSDKVRFGYINDFNGASLIAIAEAEGLWKKHGLSADAKVFTNGPLQIQALGTDNLDFGYIGPGAMWLPASGQAKVVAINTLGNSDRVLAQPGITSMQQLKGKTVAVPEGTSGDMILSLALEKAGMTKEDLKVVPMDPSTIVSAFSSQQVDGAGFWYPAAATIKKQVPDLVELAKNADFEQDVSFPTAFVAGNKVVADQPEKTKKVLAVLREAMTFRSEHTDEAIKLTADKLKIPVEQVKADAANNKVLSVAELDELTRDGTVVKWLEGMNDYFVNAGKLKKPADPKTYYTGDLFTGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ24</accession>
    <name>Q9KZ24_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2213</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626464.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028201.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2213"/>
    <dbReference type="GeneID" id="1097646"/>
    <dbReference type="KEGG" id="sco:SCO2213"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2250"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110204_0_0_11"/>
    <dbReference type="OMA" id="PPMIGYL"/>
    <dbReference type="PhylomeDB" id="Q9KZ24"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB90861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="193" mass="21295" checksum="5A58FE453564DA7A" modified="2000-10-01" version="1">MATTRSLSTVTLDSPTARPDSGGPRHRLRAVAPDEVADVVDLLPPGTTWLPAPAHTLPALPGHPPMVGYLVLVPADQQPPFRDPDRAQDPGRDGAENPLVRIDPARRTATVDGRELDLTYLEFELLAHLVAHPHRVHTRDRLVTTVWGYGHVGDGRTVDVHVARLRRKLGAQHRQTIQTVRRVGYKYTPPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZ87</accession>
    <name>Q9KZ87_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO4859</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629014.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029908.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4859"/>
    <dbReference type="DNASU" id="1100300"/>
    <dbReference type="GeneID" id="1100300"/>
    <dbReference type="KEGG" id="sco:SCO4859"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4937"/>
    <dbReference type="eggNOG" id="COG3195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092522_2_0_11"/>
    <dbReference type="InParanoid" id="Q9KZ87"/>
    <dbReference type="OMA" id="ECCYSVP"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="OHCU_decarbox" evidence="3">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="183" mass="19440" checksum="47B38AFD6C2EC81C" modified="2000-10-01" version="1">MQTRATPAPAAPLERFNAAPAEEAAGTLLACLHSRAWADRLVAHRPYPDLPALLAAADEAAYDLSSDDLSEALAAETLPALPEDTYAAAHTALSAAHAAYESRFGHVFVISLDGLSPEETLNHVLAAIRSRLANDPDEERLVASEELRRLAGGRVRRLLGARGTARPATDDPHPANHTKPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZS1</accession>
    <name>Q9KZS1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2880</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627108.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028644.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2880"/>
    <dbReference type="GeneID" id="1098314"/>
    <dbReference type="KEGG" id="sco:SCO2880"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2940"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_2_1_11"/>
    <dbReference type="InParanoid" id="Q9KZS1"/>
    <dbReference type="OMA" id="RQNMTEY"/>
    <dbReference type="PhylomeDB" id="Q9KZS1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="140" mass="14736" checksum="200EDD362C7CA004" modified="2000-10-01" version="1">MQDTHTNSLGWLLDQELGSVEGVRYAVLMSSDGLLKARTQTIGQDDGEKFAALTAALRAAGKAWDEFTGGAGMRQLLIESVGCIGLTTTAAKNTMLSVCTTGPDADVGLISHHMVRLATRVGHELATEERVPVADGGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KZU5</accession>
    <name>Q9KZU5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component systen response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO4156</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628333.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029472.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9KZU5"/>
    <dbReference type="STRING" id="100226.SCO4156"/>
    <dbReference type="GeneID" id="1099596"/>
    <dbReference type="KEGG" id="sco:SCO4156"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4220"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_11"/>
    <dbReference type="InParanoid" id="Q9KZU5"/>
    <dbReference type="OMA" id="NYEFFGD"/>
    <dbReference type="PhylomeDB" id="Q9KZU5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="248" mass="27651" checksum="5008913BFCAE24A9" modified="2000-10-01" version="1">MSPADADRDRDREIQRILIVDDEPAVREALQRSLAFEGYDTEVAVDGADALEKATAYRPDLVVLDIQMPRMDGLTAARRIRGAGDLTPILMLTARDTVGDRVTGLDAGADDYLVKPFELDELFARIRALLRRSSYAAAVEATAEDDDTLTFADLTMDLATREVSRAGRPVELTRTEFTLLEMFMAHPRQVLTREQILKAVWGFDFEPSSNSLDVYVMYLRRKTEAGGEPRLVHTVRGVGYVLRQGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L093</accession>
    <name>Q9L093_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2453</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB86118.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626696.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976351.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2453"/>
    <dbReference type="GeneID" id="1097887"/>
    <dbReference type="KEGG" id="sco:SCO2453"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2495"/>
    <dbReference type="HOGENOM" id="CLU_201956_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB86118.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="72" mass="7547" checksum="6626E7E07AFEA9C6" modified="2000-10-01" version="1">MVPVSRTGYPCRDRPAGGGTTMSEPTPSQAEGERDDEPDTPDVPHTTPSQAEGERDDEGESAPVVQPPGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L0I6</accession>
    <name>Q9L0I6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4771</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAB82010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628929.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974202.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4771"/>
    <dbReference type="GeneID" id="1100212"/>
    <dbReference type="KEGG" id="sco:SCO4771"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4844"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064068_0_0_11"/>
    <dbReference type="OMA" id="AARRDYM"/>
    <dbReference type="PhylomeDB" id="Q9L0I6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB82010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="374" mass="40116" checksum="687FB4C709B9A32B" modified="2000-10-01" version="1">MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPATAIRIGELGGLGVLNLEGLWTRHEDPQPLLDEIAELDTDNATRRLQEIYAAPIKEELIGQRIKEVRDSGVVTAAALSPQRTAQFSKAVVDAGVDIFVIRGTTVSAEHVSGSHEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGWSGDLPKAIACGADSVMMGSPLARATDAPGRGNHWGMEAVNEELPRGKKVDLGTVGTIEEILTGPSRNPDGSMNFFGALRRAMATTGYSELKEFQRVEVTVADSQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L129</accession>
    <name>Q9L129_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7430</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631479.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031658.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7430"/>
    <dbReference type="GeneID" id="1102868"/>
    <dbReference type="KEGG" id="sco:SCO7430"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7540"/>
    <dbReference type="eggNOG" id="COG1865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077662_1_0_11"/>
    <dbReference type="InParanoid" id="Q9L129"/>
    <dbReference type="OMA" id="WVLNAQV"/>
    <dbReference type="PhylomeDB" id="Q9L129"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="228" mass="22998" checksum="74FCE4F9899095FA" modified="2000-10-01" version="1">MPALLPPPRTGADRLLDPDDLIRVEDGERLHALLWRPGPGWRMVSSAVLGGGTGERAWVLNAQVAHGYRRTDPARHLAELARAAGARGPGVGLMTAADVSAHGRARDGGAEAVATAGISVRGWAAAPQEGTAGAGPPGTINIVAALPVALSDAALVNAVMTATEAKVQALLDAGLDCSGTPTDAVCVAARAPVGEAEVHAFAGPRSEWGARLARAVHRAVGAALPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1E5</accession>
    <name>Q9L1E5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AbaA-like regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5460</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB76014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629597.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030263.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5460"/>
    <dbReference type="GeneID" id="1100900"/>
    <dbReference type="KEGG" id="sco:SCO5460"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5544"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_4_2_11"/>
    <dbReference type="OMA" id="KTTWFEM"/>
    <dbReference type="PhylomeDB" id="Q9L1E5"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="101"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB76014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="220" mass="23743" checksum="5BCBED7F3E5E21C2" modified="2000-10-01" version="1">MSPAEPFAQVKGAVSGPELPVAYADRPSSDRAPAEAYSPGTAPEAPGGGHDGGMAGLDGTEQPRGAGRATAARWSPAVEDERALKALDLFGNPTEHEVPLPSRPESAATARRLAQVVALRQWQLGPKVTEDAVLLVSELVGNAVRHTGARVFGLRMRRRPGWIRVEVRDPSRGLPCLMPVQETDISGRGLFLVDKLSDRWGVDLLPRGKTTWFEMRVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L1R2</accession>
    <name>Q9L1R2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO6852</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB72357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630922.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031237.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6852"/>
    <dbReference type="GeneID" id="1102291"/>
    <dbReference type="KEGG" id="sco:SCO6852"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6962"/>
    <dbReference type="eggNOG" id="ENOG5031AYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084482_0_0_11"/>
    <dbReference type="OMA" id="HAGQIPF"/>
    <dbReference type="PhylomeDB" id="Q9L1R2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005523">
        <property type="entry name" value="DUF317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03771">
        <property type="entry name" value="SPDY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SPDY" evidence="2">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB72357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="273" mass="30180" checksum="703AA8071ABC4C4B" modified="2000-10-01" version="1">MPLNERQLDAFADEHAGQIPFDASPRHLAGPGDARHVTHGLAAAGWATISDPLSAEIVMASPDHRYRLQYDPQSATSAWWRLRATSADNEHGWYAEFGELVPAEVLSSLTDALIAPASPQSDPWQPVTSAGWRPDEAGAAHSPDAMCHIERRPTSEFHERPSWHIEVRDAHDTQYPGPRIWHAYLDEHAPDHLVGAFLSALTDQSPLQRGMFDRTAHYSAVKEPSPLRPQQVVDAHTSRVKVLRAQARAMRRQQTAPAKPPAPTTAVQPAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L227</accession>
    <name>Q9L227_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6805</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630877.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031193.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6805"/>
    <dbReference type="GeneID" id="1102244"/>
    <dbReference type="KEGG" id="sco:SCO6805"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6915"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_17_3_11"/>
    <dbReference type="InParanoid" id="Q9L227"/>
    <dbReference type="OMA" id="MWATTVQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="434" mass="43444" checksum="3AAC9AC1517C94A9" modified="2000-10-01" version="1">MAGTSLRPTAARAVWSRDFALFFAARAVARLGDTMLPVALAAGLLQHGYGAGAVGLAMAATAAAFAGLVVFGGVLADRFSTRKLMIGADLVRLGTQALAAALFFSGHVVLWQICAIGFANGVAGAVFQPGVASTVPRLASDVQGANGAIRVAESAAQLAGPAVAGLLVGFASPGGVFAAHATTYAVSALCLLLLRLPPPAPGSRAVSGRGSKAFRADLVQGWREFLARRWLWNVIAVWCVYMIAVWGPTVPLVATEVVGEHGPRAYGLVNSALGAGTVVGGLLALRLRPVRMLRAGAIALVGFAAFPASVGAGLGVPAMAAGAAVAGAGMSFWGVMWATSVQTQVPPDVLNRIHAYDVAGSLAMMPVGQALAGPAAAALGADRVLLVAGVTSFAVCAALLLIPAVRGLVRVDAAAAGSSGTAAAAAEPSRAQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L237</accession>
    <name>Q9L237_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6795</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939129">
        <property type="protein sequence ID" value="CAB71242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630867.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972203.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6795"/>
    <dbReference type="GeneID" id="1102234"/>
    <dbReference type="KEGG" id="sco:SCO6795"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6905"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094585_1_1_11"/>
    <dbReference type="InParanoid" id="Q9L237"/>
    <dbReference type="OMA" id="SDLDWLM"/>
    <dbReference type="PhylomeDB" id="Q9L237"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB71242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="144" mass="14834" checksum="93524C83838AA389" modified="2000-10-01" version="1">MASDAPTGQVSDLDWLMSGLVQRVPHTSSAVLLSADGLVKSVHGLDADSADHMAALASGLYSLGRSAGVRFGDGGDVRQVVVELASTLLFVTTAGSGTCLAVLAGREADAAVLGYEMAMLVKSVRPYLVTAPRQHTAEPPAMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2A0</accession>
    <name>Q9L2A0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical hydrophilic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO5422</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939123">
        <property type="protein sequence ID" value="CAB70652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629561.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030237.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5422"/>
    <dbReference type="GeneID" id="1100862"/>
    <dbReference type="KEGG" id="sco:SCO5422"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5503"/>
    <dbReference type="eggNOG" id="ENOG5033K1G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640789_0_0_11"/>
    <dbReference type="OMA" id="DIGDLHQ"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB70652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="456" mass="46698" checksum="6B21CD230887D5E0" modified="2000-10-01" version="1">MKHGMDEETSRARTGPRHAAPRKPLFTRFQVPTGKAIALAAMPTAVLMGLGFTPTLALADGNDQGAPSSNSLTADEYKACVEAMADAEKDASQSPEPSPSATDDGKQDETEPSASPSAGDTGEKPGTDKDASSSSDSGSDDKDDTAAGDNAADGDKSEPAPSPSASEGKESVGASAAEPSPSESERGGLLEGIGDAIEGIFTGGEKAEETASPTPTPSASQSAGDDASDVVKETTDKVTGTVKDTVDGATDAASKAAEDTKDTVDKATEDAEKAAEEAKDEVTASPSADPSESAAVDPEDCPAATDEEGGVDNTLPVPEDPWYLEASSLTLKGASYKGIVEVKTASGATKKVLKYVISKGTDIGDLHQIVKDDTTGRTHHVQAAKGSTSTIRDGDTVMYTESISGNLLGLIPITFDPKNPPPLDIPLIYFTNVKVVQAGQFGGTLHVPGLHQYITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2I7</accession>
    <name>Q9L2I7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0722</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625027.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978139.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0722"/>
    <dbReference type="DNASU" id="1096145"/>
    <dbReference type="GeneID" id="1096145"/>
    <dbReference type="KEGG" id="sco:SCO0722"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.711"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_4_0_11"/>
    <dbReference type="InParanoid" id="Q9L2I7"/>
    <dbReference type="OMA" id="DIQACLF"/>
    <dbReference type="PhylomeDB" id="Q9L2I7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB69694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="26585" checksum="2B1541CB75189A73" modified="2000-10-01" version="1">MTTQLGLPDDIQACLFDLDGVVTRTAVVHAAAWKATFDTFLRERDGADFRPFTDSDYDQYVDGRPRADGVRSFLASRGVELPEGTPDDPPDARTVNGVGNRKNELLLEKIRTDGVEPYEGTLRYIDAVRAAGLATAIVSSSANTRDVLRSIDAERLFDVRIDGVVARERKLPGKPHPDTFLAAARDLGVEASRAAVFEDALAGMDAGRSGHFGYVVGVDRVGQTDALYAHGADRVVKDLAELGDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9L2J5</accession>
    <name>Q9L2J5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0714</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB69686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625019.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027311.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1096137"/>
    <dbReference type="KEGG" id="sco:SCO0714"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.702"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081768_0_0_11"/>
    <dbReference type="InParanoid" id="Q9L2J5"/>
    <dbReference type="OMA" id="LWDIGPH"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB69686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="295" mass="30531" checksum="712385F69315EE0D" modified="2000-10-01" version="1">MRIGLLGTGPWADMAHAPALAGHDDLDFAGVWGRRPDAAEELAQRHGTRAYADLDALLADVEAVAVALPPAVQAGLAVRAARAGCHLLLDKPLASTVAQGRAVVEAVRTADVASVVFFTTRFQPETEAWITEQSSRDDWFTARAQWLGAVFGGEDSPFADSPWRREKGALWDVGPHALSVLLPVLGDARRVAAAAPGPGDTVHLVLDHTGGASSTLTLSLTAPPAAAGAAVELRGRAGVTLLPETTQGPVPALRRAADALLAAAGGGRPHPCDAAFGLRVTEILAEAEGLLTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RD85</accession>
    <name>Q9RD85_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0792</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB66192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625093.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027358.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0792"/>
    <dbReference type="GeneID" id="1096215"/>
    <dbReference type="KEGG" id="sco:SCO0792"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.784"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RD85"/>
    <dbReference type="OMA" id="DAAYCRE"/>
    <dbReference type="PhylomeDB" id="Q9RD85"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="343" mass="36948" checksum="B3735C0C8A05901C" modified="2000-05-01" version="1">MSSATGSKIVVTGATGNVGTSVVRLLSEDPEVGTVLGLARRIPDWSPAKTEWAAVDLASEQSDLTSHFADADAVVHLAWAFQPTHDPATTWRTNVLGSIRVFEAVAAAGVPALVHASSVGAYSPGPKNHAVDESWPTHGWPDAAYCREKAYLERALDTFERDHPGIRVVRMRPAFLFKRESASEQRRIFGGRFLPGPAARPELLPFLPDVPGLRVQALHTDDAARAYRLAVRSADARGAFNLAAEPPVDAELLGELLGVRPVRLPRAAARSAIAAAWGMRLLPASPHLFDAVLRLPVMDCTRARVELGWGATRTATEVLEEFLRGLRQGAGADTEPMRGRKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RDS1</accession>
    <name>Q9RDS1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2246</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB66180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626495.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028221.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2246"/>
    <dbReference type="GeneID" id="1097679"/>
    <dbReference type="KEGG" id="sco:SCO2246"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2284"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055817_0_0_11"/>
    <dbReference type="OMA" id="PTARAEH"/>
    <dbReference type="PhylomeDB" id="Q9RDS1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB66180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="258" mass="28867" checksum="DEA2D4A9A139C7B5" modified="2000-05-01" version="1">MSVNGEADEPGWEVDPDDEWGVAVLTTVGRQLKLRREAVGLRAGDFGVAVGYGEDLVYKVEGGKRIPRREYLEKADQVLRADGLIAAAWEDVKKVRYPKQVRDLAKLESRAVESLSYGSYSLHGLLQTEEYARALLGRRRPALTDDEVESAVAARMGRKAMLERDPAPELSFVQEEATLRRPVGGMMVLRRQLEHLLEVEQLRHVEIQVMPTSRGDHPGGGRMQVLKFDDGTAVGRADDLFGARPVTDPRQLRILELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RI68</accession>
    <name>Q9RI68_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0109</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37009">
        <property type="entry name" value="T37009"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624452.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026853.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0109"/>
    <dbReference type="GeneID" id="1095534"/>
    <dbReference type="KEGG" id="sco:SCO0109"/>
    <dbReference type="HOGENOM" id="CLU_1685528_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="156" mass="17089" checksum="0847EF49A8E39932" modified="2000-05-01" version="1">MVRDRLRQRPDPQREVNADVSAADHHTPWQYCRAVPSPPARQTFSQATAQPGEQAAIDHGGTVRRGQGYSLRASTIQVIHRQMLARCQPLDGGHGTPTVPAQRKARREYENASARSSRPAPRLGINPSRPATTSCTSRPACTAEDCFALPPIVNVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RIY7</accession>
    <name>Q9RIY7_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0178</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB53145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36960">
        <property type="entry name" value="T36960"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624514.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978699.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0178"/>
    <dbReference type="GeneID" id="1095602"/>
    <dbReference type="KEGG" id="sco:SCO0178"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.151"/>
    <dbReference type="HOGENOM" id="CLU_1757737_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB53145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="148" mass="15197" checksum="7BEC605EBB112B83" modified="2000-05-01" version="1">MLVAQALSAAAVVVGHRGPHPFQGALIGSLATGLAAHSECPVVVVGEPENPAGPVALGVDGSAAGAAAVRLPGDFRAGCGHHRRARLDGLERADAASPRRETEPYACEPGMLAAEEGRLLAETLAGMCARYPEVRVERSTVHGVHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ71</accession>
    <name>Q9RJ71_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1630</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625905.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977196.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1630"/>
    <dbReference type="GeneID" id="1097061"/>
    <dbReference type="KEGG" id="sco:SCO1630"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1645"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021841_1_0_11"/>
    <dbReference type="OMA" id="HGRNPEV"/>
    <dbReference type="PhylomeDB" id="Q9RJ71"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="262"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="541" mass="58612" checksum="F48DEC4E26D739C1" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-16" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJ79</accession>
    <name>EX53_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>5'-3' exonuclease</fullName>
            <ecNumber>3.1.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">SCO1622</name>
        <name type="ORF">SCI41.05</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5'-3' exonuclease acting preferentially on double-stranded DNA.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.-"/>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAB59475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625897.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027889.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJ79"/>
    <dbReference type="SMR" id="Q9RJ79"/>
    <dbReference type="STRING" id="100226.SCO1622"/>
    <dbReference type="GeneID" id="1097053"/>
    <dbReference type="KEGG" id="sco:SCO1622"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1637"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_1_3_11"/>
    <dbReference type="OMA" id="WRVDLIP"/>
    <dbReference type="PhylomeDB" id="Q9RJ79"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000101291" description="5'-3' exonuclease">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exonuclease" evidence="2">
        <location>
            <begin position="182"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <sequence length="301" mass="31915" checksum="6FF3522ABEB1A9F7" modified="2000-05-01" version="1">MLLDTASLYFRAYFGVPDSVKAPDGTPVNAVRGLLDFIDRLVKDHRPEHLVACMDADWRPHWRVELIPSYKAHRVAEERPAGPDAEEVPDTLSPQVPVIEAVLDALGIARVGVAGYEADDVIGTYTARATGPVDIVTGDRDLYQLVDDARGVRVLYPVKGVGTLNLVDEAALREKYGVDGAGYADLALLRGDPSDGLPGVPGIGEKTAAKLLAEFGDLAGIQAAVDDPKARLTPTQRKRLTEAGPYLAVAPKVVRVAADVPLPDTGTALPHGPRDAAALEALAARWGLGGSLQRLLTTLTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJA9</accession>
    <name>GVPJ2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Probable gas vesicle protein GvpJ 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gvpJ2</name>
        <name type="ordered locus">SCO0655</name>
        <name type="ORF">SCF91.15</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. This protein could be important for the shape determination of the gas vesicle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole</location>
            <location evidence="3">Gas vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAB61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624964.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978207.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RJA9"/>
    <dbReference type="SMR" id="Q9RJA9"/>
    <dbReference type="STRING" id="100226.SCO0655"/>
    <dbReference type="GeneID" id="1096078"/>
    <dbReference type="KEGG" id="sco:SCO0655"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.639"/>
    <dbReference type="eggNOG" id="ENOG503303G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107602_2_2_11"/>
    <dbReference type="InParanoid" id="Q9RJA9"/>
    <dbReference type="OMA" id="ELIHIRI"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0304">Gas vesicle</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000200001" description="Probable gas vesicle protein GvpJ 2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="114" mass="12443" checksum="A4B20D6E930CE9CE" modified="2000-05-01" version="1">MTDLDHRYPGEETEPYGPPSGSLADLLERVLDKGIVIAGDIKIDLLDIELLTIRLRLFIASVDTAKKAGIDWWETDPALSSRAARDALAEENARLRERLDALEGAAGETTGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RJW0</accession>
    <name>Q9RJW0_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0350</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB55712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624673.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027042.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0350"/>
    <dbReference type="GeneID" id="1095773"/>
    <dbReference type="KEGG" id="sco:SCO0350"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.325"/>
    <dbReference type="eggNOG" id="COG3618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_3_0_11"/>
    <dbReference type="InParanoid" id="Q9RJW0"/>
    <dbReference type="OMA" id="DWPVCLV"/>
    <dbReference type="PhylomeDB" id="Q9RJW0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB55712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="294" mass="31554" checksum="9010AC6145DD2131" modified="2000-05-01" version="1">MTVVDAHLHVWDPEQAAYEWLGPAMAPVDRAMRFHDALPALRTAGVGAAVLVQAADNDEDTDLMLATAARHPEVVGVVAWVPLDDPGRARARLAALRRDPHVVGVRTLLHERSDPDWVLGPDADAGLALLAEAGLPFDYSTTSPAALRHLAELSARHPALRLVVDHLGKPPVGGGREDRAEWHRLIAAAAKHPGVHAKLSGLYSASGALDAWTTDEVRPFVEDALELFGPERLMYGGDWPISLLAGGYARTWEAMCELLAPLAPDDRAAVLGGTATRFYRLDPALLNTAHHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RK18</accession>
    <name>Q9RK18_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO0488</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB53318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36406">
        <property type="entry name" value="T36406"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624805.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027153.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0488"/>
    <dbReference type="CAZy" id="CBM67">
        <property type="family name" value="Carbohydrate-Binding Module Family 67"/>
    </dbReference>
    <dbReference type="CAZy" id="GH78">
        <property type="family name" value="Glycoside Hydrolase Family 78"/>
    </dbReference>
    <dbReference type="GeneID" id="1095911"/>
    <dbReference type="KEGG" id="sco:SCO0488"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.468"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002926_1_1_11"/>
    <dbReference type="InParanoid" id="Q9RK18"/>
    <dbReference type="OMA" id="IAPEAWS"/>
    <dbReference type="PhylomeDB" id="Q9RK18"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_rhamnosid_N" evidence="6">
        <location>
            <begin position="409"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid" evidence="5">
        <location>
            <begin position="590"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid6H" evidence="7">
        <location>
            <begin position="697"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_rhamnosid_C" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB53318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124252" checksum="DDC4700DD28DE26D" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKN7</accession>
    <name>Q9RKN7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2291</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50600">
        <property type="entry name" value="T50600"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626539.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028254.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2291"/>
    <dbReference type="CAZy" id="CBM2">
        <property type="family name" value="Carbohydrate-Binding Module Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="1097724"/>
    <dbReference type="KEGG" id="sco:SCO2291"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2328"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049732_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKN7"/>
    <dbReference type="OMA" id="QVDAGMW"/>
    <dbReference type="PhylomeDB" id="Q9RKN7"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176941" evidence="1">
        <location>
            <begin position="37"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="46"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="2">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB61737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="335" mass="34106" checksum="04ACFBCC8FE29121" modified="2000-05-01" version="1">MRTSTGPRASSRTLRTLASGVAVTALAAAGTVAAGAAPAQAAACNGYVGLTFDDGPSGSTQSLLNALRQNGLRATMFNQGQNAAQNPSLVRAQVDAGMWVANHSYTHPHMTQLGQAQMDSEISRTQQAIAGAGGGTPKLFRPPYGETNATLRSVEAKYGLTEVIWDVDSQDWNNASTDAIVQAVSRLGNGQVILMHDWPANTLAAIPRIAQTLAGKGLCSGMISPQTGRAVAPDGSGGGGDGGGGGGGACTATLSAGQRWGDRYNLNVSVSGASDWTVTMNVPSPAKVLSTWNVNASYPSAQTLTAKSNGSGGNWGATIQANGNWTWPSVSCTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKQ1</accession>
    <name>Q9RKQ1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO2277</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50586">
        <property type="entry name" value="T50586"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626525.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976536.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2277"/>
    <dbReference type="GeneID" id="1097710"/>
    <dbReference type="KEGG" id="sco:SCO2277"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2314"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077905_0_0_11"/>
    <dbReference type="InParanoid" id="Q9RKQ1"/>
    <dbReference type="OMA" id="WYGTLLK"/>
    <dbReference type="PhylomeDB" id="Q9RKQ1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB61723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="290" mass="30912" checksum="377375015895970E" modified="2000-05-01" version="1">MFSNYLIGLREGLEASLVVCILIAYLVKTDRRDALKPIWAGIGVAVAIALGFGCALEFGSQELTFKAQEALGGSLSILAVVLVTWMVFWMRRTARHLKTELHGRLDAALAMGTGALVATAFLAVGREGLETALFVWASVHAASDGTPRPLIGVALGLATAVLLGWLFYRGALRINLARFFTWTGGMLVVVAAGVLAYGVHDLQEADLVPGLTNLAFDISSTIDPSSWYGTLLKGVFNFQPDPTVLQVTVWLLYLVPTLALFLAPVGFASGKGKVKEPDEPGSRPSKAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKR3</accession>
    <name>Q9RKR3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2265</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50574">
        <property type="entry name" value="T50574"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626513.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028235.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2265"/>
    <dbReference type="GeneID" id="1097698"/>
    <dbReference type="KEGG" id="sco:SCO2265"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2302"/>
    <dbReference type="eggNOG" id="ENOG5033BD3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191180_1_0_11"/>
    <dbReference type="OMA" id="WHDAPSA"/>
    <dbReference type="PhylomeDB" id="Q9RKR3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB61711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="92" mass="10403" checksum="A9DA13665B2D1F3F" modified="2000-05-01" version="1">MGEHVGGERSCPMALFKKRTVGKPGEWFYCLEHQKVEEGPDCPGKDRFGPYATRTEAEHAMQTARERNLEWENDPRWHDAPSAGGADGDRDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RKS2</accession>
    <name>PANB_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="1">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panB</name>
        <name type="ordered locus">SCO2256</name>
        <name type="ORF">SCC75A.02</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB61702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T50565">
        <property type="entry name" value="T50565"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626504.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976556.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9RKS2"/>
    <dbReference type="SMR" id="Q9RKS2"/>
    <dbReference type="STRING" id="100226.SCO2256"/>
    <dbReference type="GeneID" id="1097689"/>
    <dbReference type="KEGG" id="sco:SCO2256"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2293"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_11"/>
    <dbReference type="InParanoid" id="Q9RKS2"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="PhylomeDB" id="Q9RKS2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184897" description="3-methyl-2-oxobutanoate hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="291" mass="30863" checksum="A94191BBE0F9A73C" modified="2000-05-01" version="1">MTQLSAAQTPQPKPADGNRALYGGKINRRITVRDITAAKERGEKWPMLTAYDAMTASVFDESGIPVMLVGDSAGNCHLGYETTVPVTLDEMTMLSAAVVRGTSRALIVGDLPFGSYQEGPVQALRSATRLVKEAGVGAVKLEGGERSHRQIELLVESGIPVMAHIGLTPQSVNSMGYRVQGRGEEAAQQLLRDAKAVQDAGAFAVVLELVPAELAAEVTRTLHIPTVGIGAGPDTDAQVLVWTDMLGLTGGRMPKFVKQYADLRKVMGDAAKAYAEDVVGGTFPADEHSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2021-04-07" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9RL60</accession>
    <name>Q9RL60_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO0426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939105">
        <property type="protein sequence ID" value="CAB56656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624747.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003978440.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0426"/>
    <dbReference type="GeneID" id="1095849"/>
    <dbReference type="KEGG" id="sco:SCO0426"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.402"/>
    <dbReference type="eggNOG" id="ENOG50324SZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2652783_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB56656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="76" mass="8347" checksum="BFE34B0AA9E2BD46" modified="2000-05-01" version="1">MEIPRHLIELRRAVEAADNRYRSNRGENATVALAVWSDATAALARGIAAYADETGVPHREVELAVQRATGRHTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S203</accession>
    <name>Q9S203_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO0123</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939104">
        <property type="protein sequence ID" value="CAB52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37053">
        <property type="entry name" value="T37053"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_624462.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011026864.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0123"/>
    <dbReference type="GeneID" id="1095547"/>
    <dbReference type="KEGG" id="sco:SCO0123"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.100"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024186_5_0_11"/>
    <dbReference type="OMA" id="NGPVTGM"/>
    <dbReference type="PhylomeDB" id="Q9S203"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071731">
        <property type="term" value="P:response to nitric oxide"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="448" mass="48635" checksum="10D858A50084816E" modified="2000-05-01" version="1">MSAPPTAPADPSTGSDRPKRSVPPPRHPTHAVDRAFLDLERRRPEVRWDAGGVAYLSGPPPSLADLRAYVAFRLGELPLLTSRVTGGRRPGWQPSEDFPVDRHVYEVVADGPADWDTALHSALNAPFAPGAYWGVWLIHGHEPDAYALCYRFLHACQDGSAAAMTFRAMLGDGEPSARPLPGGSGVFGVPRRFGAAVALATRFLARTFTVRRHRPDPAFAPAGERRLWRGRVPVDTLRLIGAGRGGSAHDAHLAALAGALSVWAARSGVPLPRVTAVLPVDARRADEEQTWGNRCFALPVDLPVGPAPGRPDGSPDEEAPLRRLDQIMAVTRKLRGDTWRQAVQDLVRYMPDRPTAWYLRRMLSPRVTNVMATSMPLAEKGSLGETRVTGTALLPLLVPGHLCGVGLSFFGDWAEVSFVADRALPLGELLPELWEQAVRELAESVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S296</accession>
    <name>Q9S296_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative secreted cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1734</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36756">
        <property type="entry name" value="T36756"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626007.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027945.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9S296"/>
    <dbReference type="STRING" id="100226.SCO1734"/>
    <dbReference type="CAZy" id="AA10">
        <property type="family name" value="Auxiliary Activities 10"/>
    </dbReference>
    <dbReference type="GeneID" id="1097165"/>
    <dbReference type="KEGG" id="sco:SCO1734"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1752"/>
    <dbReference type="eggNOG" id="COG3397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039396_0_1_11"/>
    <dbReference type="InParanoid" id="Q9S296"/>
    <dbReference type="OMA" id="PEAFYTC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176965" evidence="3">
        <location>
            <begin position="29"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="4">
        <location>
            <begin position="34"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="356" mass="35476" checksum="B58FD3A6EB65FA54" modified="2000-05-01" version="1">MPAPSASRRAAAVAVAGLAPLALTTLAAAPASAHGSMGDPVSRVSQCHAEGPENPKSAACRAAVAAGGTQALYDWNGIRIGNAAGKHQELIPDGRLCSANDPAFKGLDLARADWPATGVSSGSYTFKYRVTAPHKGTFKVYLTKPGYDPSKPLGWGDLDLSAPVATSTDPVASGGFYTFSGTLPERSGKHLLYAVWQRSDSPEAFYSCSDVTFGGDGDGDGDGGSGSGAATGDDTASGDAEAGAAPAPEASAPSEEQLAAAAEKSTIEHHGHGDQDAATTTDPTDPAAAPEEAPGTAAEPHQVKAAGGGTENLAETGGDSTTPYIAVGGAAALALGAAVLFASVRRRATTGGRHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2G1</accession>
    <name>Q9S2G1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO2920</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939114">
        <property type="protein sequence ID" value="CAB51001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36143">
        <property type="entry name" value="T36143"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627146.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028663.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2920"/>
    <dbReference type="GeneID" id="1098353"/>
    <dbReference type="KEGG" id="sco:SCO2920"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2978"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010858_0_0_11"/>
    <dbReference type="InParanoid" id="Q9S2G1"/>
    <dbReference type="OMA" id="WAHRWYA"/>
    <dbReference type="PhylomeDB" id="Q9S2G1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176970" evidence="2">
        <location>
            <begin position="33"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="3">
        <location>
            <begin position="100"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB51001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="781" mass="85759" checksum="0949361E506821EF" modified="2000-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9S2W3</accession>
    <name>Q9S2W3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO2093</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB52002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34963">
        <property type="entry name" value="T34963"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626352.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028134.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2093"/>
    <dbReference type="GeneID" id="1097527"/>
    <dbReference type="KEGG" id="sco:SCO2093"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2126"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_084253_1_2_11"/>
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    <dbReference type="OMA" id="DQDVRQS"/>
    <dbReference type="PhylomeDB" id="Q9S2W3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB52002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="167" mass="18431" checksum="4739AEDED4774AF9" modified="2000-05-01" version="1">MADHTVTDRLVEANERYAAAFADPGMDARPVQRVAVVACMDARLDLHAALGLKLGDCHTIRNAGGVVTDDVIRSLTISQRALGTRSVALIHHTGCGMETITEEFRHDLELEVGQRPAWAVEAFRDADQDVRQSIERVRTSPFLLHTEDVRGFVFDVKTGLLREVDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7T7</accession>
    <name>Q9X7T7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7262</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAB42955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35346">
        <property type="entry name" value="T35346"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631318.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031549.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7262"/>
    <dbReference type="GeneID" id="1102700"/>
    <dbReference type="KEGG" id="sco:SCO7262"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7364"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3048494_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB42955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="54" mass="5485" checksum="BA5A1D26C5C7FC07" modified="1999-11-01" version="1">MVPLDVRTLPARARLGADLGHPAITESAGLFARPDVVAGAPVRKASYSGALNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X7Z7</accession>
    <name>Q9X7Z7_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2138</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB39865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35520">
        <property type="entry name" value="T35520"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626394.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976677.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2138"/>
    <dbReference type="GeneID" id="1097572"/>
    <dbReference type="KEGG" id="sco:SCO2138"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2173"/>
    <dbReference type="eggNOG" id="ENOG5033JSG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190791_0_0_11"/>
    <dbReference type="OMA" id="SERWRCT"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="79" mass="8879" checksum="35B7B1C141FAFA9C" modified="1999-11-01" version="1">MTVPLPTDTTRWRCTLCGNLTRFDVTRASKVVEYVHLDLAGEPTVEEREVLSETVESVRCRWCNAVDQVELVDRPGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X826</accession>
    <name>Q9X826_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6059</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35851">
        <property type="entry name" value="T35851"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630168.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030624.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6059"/>
    <dbReference type="GeneID" id="1101500"/>
    <dbReference type="KEGG" id="sco:SCO6059"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6160"/>
    <dbReference type="eggNOG" id="ENOG5031FDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685611_0_0_11"/>
    <dbReference type="OMA" id="PHYVEEF"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB41552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="181" mass="19653" checksum="2D611A2DD5653059" modified="1999-11-01" version="1">MVSAGSGTAYGGWAHGPSKEKGRLVFTSVLMIEKALTSADVEFVTTLHGDEQVGFHVLLQPRGDQADRLLRAIDDVALGELDDAVREGETPEGREAQSVGERALEVSLTALRASGAQADGRLIEDHPLDELKSVVMETGADEVIVLTDPHYVEEFFHRDWASRARHKVGVPVLKLFSHSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X840</accession>
    <name>Q9X840_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO6074</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB41567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35866">
        <property type="entry name" value="T35866"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630183.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030633.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6074"/>
    <dbReference type="GeneID" id="1101515"/>
    <dbReference type="KEGG" id="sco:SCO6074"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6176"/>
    <dbReference type="eggNOG" id="ENOG5030HUF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1395581_0_0_11"/>
    <dbReference type="OMA" id="TVRHESG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="49"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAB41567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="203" mass="19786" checksum="674A9F016E302552" modified="1999-11-01" version="1">MPGRDPGPGTEPDGARHPHTGRRRRRRLTTLLLGVLAAAVLLLTGVGLGTVGATVIGMSKLAELRQRAAAQGPGGAGGAGGAGEQGATGTATGTRGAPAHPSAGPSAGRSPSPAPAGATLGVEAVDDEKPGARVVGVHVPGPGYAAGLVRGDVLLAVGTTRVDSATDLAHAVARAGPGKEVKLTVRHRSGGYQQLTAVPGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X8R3</accession>
    <name>Q9X8R3_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="2" type="ordered locus">SCO3646</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36536">
        <property type="entry name" value="T36536"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627840.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029139.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3646"/>
    <dbReference type="GeneID" id="1099082"/>
    <dbReference type="KEGG" id="sco:SCO3646"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3706"/>
    <dbReference type="eggNOG" id="COG3483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063240_0_0_11"/>
    <dbReference type="InParanoid" id="Q9X8R3"/>
    <dbReference type="OMA" id="WRWRNDH"/>
    <dbReference type="PhylomeDB" id="Q9X8R3"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019442">
        <property type="term" value="P:tryptophan catabolic process to acetyl-CoA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="271" mass="30368" checksum="0CA8AC647BA5868A" modified="1999-11-01" version="1">MSHDAPNLDFEGSTPYEDYVKADVLTHLQHTLSDDPGEMVFLVTTQVMELWFTVIVHEWETAARALREDRTPVATDALKRSVRELEALNASWTPLAGLTPAQFNSYRSALGEGSGFQSAMYRRLEFLLGDKSASMLVPHRGAPRVHAELEKALHEPSLYDEVVRLLARRGYDIPDAVLQRDLTRKYEAAPEVEAAWTAVYSGDQNGELARLGEALTDVAELVWRWRNDHLVATRRAMGSKTGTGGSAGVAWLEKRARNNVFPELWTARSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X924</accession>
    <name>Q9X924_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO3559</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB38496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36680">
        <property type="entry name" value="T36680"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627757.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975377.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3559"/>
    <dbReference type="GeneID" id="1098995"/>
    <dbReference type="KEGG" id="sco:SCO3559"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3615"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058793_1_0_11"/>
    <dbReference type="InParanoid" id="Q9X924"/>
    <dbReference type="OMA" id="VDRVYGH"/>
    <dbReference type="PhylomeDB" id="Q9X924"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB38496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="274" mass="28188" checksum="3737597B8D60CCF2" modified="1999-11-01" version="1">MSTTGANADPLAALGALPGVAESVESVRKAVDRVYGHRIMRRRSNEITSEAALRGARGSAALSGADWALEEVRRRSDFSGDVEARAVGAALRLTAEAGQLLSIWRQSPLRVLARLHLVAAADNADQVGRPRQNGEPVDEPLVELPLPDAQEAHGRLDGLAALVAAGGSAPALVTAAVVHGELLALRPFTSDNGLVARAAERIVLVGSGLDPKSVCPAEVGHAELGRAAYLAALDGYVSGTPEGMAAWIAHCGKAVALGARESTAVCEALQRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-11-01" modified="2021-04-07" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X941</accession>
    <name>Q9X941_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO3588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939117">
        <property type="protein sequence ID" value="CAB41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36697">
        <property type="entry name" value="T36697"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627784.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029104.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3588"/>
    <dbReference type="GeneID" id="1099024"/>
    <dbReference type="KEGG" id="sco:SCO3588"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3643"/>
    <dbReference type="eggNOG" id="COG2312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026490_2_1_11"/>
    <dbReference type="InParanoid" id="Q9X941"/>
    <dbReference type="OMA" id="QNARIIE"/>
    <dbReference type="PhylomeDB" id="Q9X941"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="387" mass="43375" checksum="5EF4BC1FF1C7E13F" modified="1999-11-01" version="1">MSRTVIRAQPFFLQAAPGSREQLANPRGFTTFVLEASWSTGLRLDTYVTRGLGDPEQIMREEFQGQYVFWDTDEYLDLIRWMRHYNVSHPGRPTLRFVGNDLGYPGPEAFDQVTSYVTAHRPGVAERIATLYAGLRPARSASAGAWMGQQLTKDLASRRAEAARAERALTLLCASGRPRGSAGRAYNWAVQNATAVAQSFTGYAFPDEEFPERMRYRDQAMADNTAWWLAHTNGRILLASNNGHVAYTSDNPQEFPEPVGAFLRKKLGRKYVSVGLTFSEGSLNALPDFTAGQPQKYAVDPAPAGHNEHTLDQVRHRDFALDLRTAPPAARAWLDTARPTRSYGLYWSDQDPETALGRSYDIVIHLHRVEAARLWAFTSVKDGQSYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X9W0</accession>
    <name>DAPA1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate synthase 1</fullName>
            <shortName evidence="1">HTPA synthase 1</shortName>
            <ecNumber evidence="1">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapA1</name>
        <name type="ordered locus">SCO1912</name>
        <name type="ORF">SCI7.30</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAB46413" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="1"/>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB46413.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36926">
        <property type="entry name" value="T36926"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626178.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X9W0"/>
    <dbReference type="SMR" id="Q9X9W0"/>
    <dbReference type="STRING" id="100226.SCO1912"/>
    <dbReference type="GeneID" id="1097346"/>
    <dbReference type="KEGG" id="sco:SCO1912"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1938"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_11"/>
    <dbReference type="InParanoid" id="Q9X9W0"/>
    <dbReference type="PhylomeDB" id="Q9X9W0"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000103166" description="4-hydroxy-tetrahydrodipicolinate synthase 1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="305" mass="31261" checksum="978C23AE67B00582" modified="2002-10-19" version="2">MTTDDDSAPFGRSLCAMVTPFTGSGALDLDGAQRLADRLVARGCDGLVLSGTTGESPTTTDAEKAALVTAVREAVGDRAALVAGVGTADTRHTVELALAAEKAGADGLLVVAPYYSRPPQDALEAHFREVADASGLPVMLYDIPGRTGTRIEPDTVVRLAAHPRIVAVKDCAYDLLGTQKVLSRTGLAYYAGCDEQILPLYAIGAAGYVSTVANVVPELFRAVLDAFDAGDTGRAALLQRRAVPLVESMMAAGLPGTVTAKALLGALGLPAGPVRAPLRSADRETTAGLLAAYGELAADAGQSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z4X6</accession>
    <name>Q9Z4X6_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CDA peptide synthetase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO3230</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2013" name="J. Mol. Biol." volume="425" first="3137" last="3150">
            <title>Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases.</title>
            <authorList>
                <person name="Bloudoff K."/>
                <person name="Rodionov D."/>
                <person name="Schmeing T.M."/>
            </authorList>
            <dbReference type="PubMed" id="23756159"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2013.06.003"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 1-449</scope>
    </reference>
    <reference evidence="13 14" key="3">
        <citation type="journal article" date="2016" name="Cell Chem. Biol." volume="23" first="331" last="339">
            <title>Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases.</title>
            <authorList>
                <person name="Bloudoff K."/>
                <person name="Alonzo D.A."/>
                <person name="Schmeing T.M."/>
            </authorList>
            <dbReference type="PubMed" id="26991102"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2016.02.012"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1-449</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AL939115">
        <property type="protein sequence ID" value="CAB38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36248">
        <property type="entry name" value="T36248"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627443.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028842.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000013.1"/>
    </dbReference>
    <dbReference type="PDB" id="4JN3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.69 A"/>
        <property type="chains" value="A/B=1-449"/>
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    <dbReference type="PDB" id="4JN5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.44 A"/>
        <property type="chains" value="A/B=1-449"/>
    </dbReference>
    <dbReference type="PDB" id="5DU9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A/B=1-449"/>
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    <dbReference type="PDB" id="5DUA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=1-449"/>
    </dbReference>
    <dbReference type="PDBsum" id="4JN3"/>
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    <dbReference type="SMR" id="Q9Z4X6"/>
    <dbReference type="STRING" id="100226.SCO3230"/>
    <dbReference type="GeneID" id="1098664"/>
    <dbReference type="KEGG" id="sco:SCO3230"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3294"/>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_222728_0_0_11"/>
    <dbReference type="InParanoid" id="Q9Z4X6"/>
    <dbReference type="PhylomeDB" id="Q9Z4X6"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_adenyl_domain"/>
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        <property type="entry name" value="ACP-like_sf"/>
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    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
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    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="CAT-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
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        <property type="entry name" value="NRPS_synth"/>
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        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="match status" value="6"/>
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        <property type="match status" value="5"/>
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        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2197"/>
            <end position="2272"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3262"/>
            <end position="3336"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4759"/>
            <end position="4834"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="5799"/>
            <end position="5874"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="6881"/>
            <end position="6955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="924"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1641"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1792"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3331"/>
            <end position="3353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="5421"/>
            <end position="5440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="6483"/>
            <end position="6510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1122"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2232"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3297"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="4794"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="5834"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="6916"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="4JN3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="4JN5"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="5DU9"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5DUA"/>
        </source>
    </evidence>
    <sequence length="7463" mass="798627" checksum="6A168F63D4CFED54" modified="1999-05-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z503</accession>
    <name>Q9Z503_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO1963</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAB38153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36036">
        <property type="entry name" value="T36036"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626227.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976856.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1963"/>
    <dbReference type="GeneID" id="1097397"/>
    <dbReference type="KEGG" id="sco:SCO1963"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1989"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_0_1_11"/>
    <dbReference type="InParanoid" id="Q9Z503"/>
    <dbReference type="OMA" id="IGESARW"/>
    <dbReference type="PhylomeDB" id="Q9Z503"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAB38153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="333" mass="36121" checksum="F4560F7B9970E05A" modified="1999-05-01" version="1">MEVSVTLWVLTIVGLAALIAVDFFIGRKPHDVSIKEAGIWTGVWIALAGLFGLGLLLFSGGEPAGEFFAGFITEKSLSVDNLFVFVLIMAKFAVPSQYQQRVLLIGVLIALVLRAVFIAAGAAILASFAWVFYIFGAFLIYTAWKLIQEARADEEDEEFEENKLLKAAERRFGVADRYHGTKLWIEENGKRIMTPMLVVMLAIGTTDVLFALDSIPAIFGLTQDPYIVFTANAFALMGLRQLYFLIGGLLRKLVHLSYGLSVILGFIGVKLVLHALHESGVHVPEISIPVSLGVICSVLIVTTITSLRASKKQAAAEAAAAGGDDTRKDSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9Z5A0</accession>
    <name>Q9Z5A0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO6202</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939126">
        <property type="protein sequence ID" value="CAB36610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34856">
        <property type="entry name" value="T34856"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630305.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030738.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1101643"/>
    <dbReference type="KEGG" id="sco:SCO6202"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6315"/>
    <dbReference type="eggNOG" id="ENOG502ZHNV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336848_0_0_11"/>
    <dbReference type="OMA" id="RWRDEYE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB36610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="214" mass="22722" checksum="14681C42C80FC0FD" modified="1999-05-01" version="1">MDGGTEIGWEPHEVALLGGGPRAAVTVALVALHLLGAVETGPGRTLCATGPEPEGLGPFEGTVLDCLREPLTARELVRHADVRLALALTRIPLAEDGLLTHPWLRPTRGARRRVAFWRERHPLPAVRHGLTDEDTLLAVALHGDAALRLLLPRFALRTGLMHPGAPADGVRFSLGRGRFLRWRDEYEDSVSGDWGGTGHGDHSGGCGSGGGGSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ZBW0</accession>
    <name>FDHD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdhD</name>
        <name type="ordered locus">SCO6558</name>
        <name type="ORF">SC4B5.08c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FdhD family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939128">
        <property type="protein sequence ID" value="CAA22362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35000">
        <property type="entry name" value="T35000"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630639.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031006.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9ZBW0"/>
    <dbReference type="SMR" id="Q9ZBW0"/>
    <dbReference type="STRING" id="100226.SCO6558"/>
    <dbReference type="GeneID" id="1101997"/>
    <dbReference type="KEGG" id="sco:SCO6558"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6662"/>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056887_3_0_11"/>
    <dbReference type="InParanoid" id="Q9ZBW0"/>
    <dbReference type="OMA" id="RYCAGAT"/>
    <dbReference type="PhylomeDB" id="Q9ZBW0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152929" description="Sulfur carrier protein FdhD">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <sequence length="282" mass="29825" checksum="FA2AE1FA6A1EF630" modified="1999-05-01" version="1">MGRVTERRKVIRIRDGAVSTRPDTLVAEEPLEIRLNGKPLAITMRTPGDDFALAAGFLVSEGVLAEQRDLQNIVYCAGATVDGSNTYNVVDVKTAPGVRIPDITLERNVYTTSSCGLCGKASLDAVRTTARWPIADTPPVRVTPELLADLPDRLRASQRVFDRTGGLHAAALFTEDGELVDVREDVGRHNAVDKLVGRALQNADLPLSRSVLLVSGRASFELAQKAVMAGIPVLAAVSAPSSLAVDLAAETGLTLVGFLRGSSMNVYAGADRVALRAAVGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-06-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O50528</accession>
    <name>O50528_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO5854</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAA15811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35890">
        <property type="entry name" value="T35890"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629977.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030499.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5854"/>
    <dbReference type="GeneID" id="1101296"/>
    <dbReference type="KEGG" id="sco:SCO5854"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5953"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_0_0_11"/>
    <dbReference type="InParanoid" id="O50528"/>
    <dbReference type="OMA" id="LLDVRWQ"/>
    <dbReference type="PhylomeDB" id="O50528"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="16"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="166"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA15811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="283" mass="28986" checksum="F9FAE0C6197C3483" modified="1998-06-01" version="1">MNAIISASELADELAGPNPPVLLDVRWQLSTAKAAGAPPFDGRAEYAAGHLPGAVYVDLDRELASAPGVNGRHPLPEVGEFGAAMRRAGVSHGRPVVVYDGGQGWAAARAWWLLRWTGHPNVRVLDGGLPSWEAPLSADVPAPAEGDFTPAPGATGLLDADGAAALARSGVLFDARAGERYRGEVEPIDPVGGHIPGAVSAPTTANVAPDGHFLPAEELRARFKTLGATEDGAVGVYCGSGVSAAHEVLALTVAGIPAALYVGSWSEWSSDPARPVAVGPDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O86638</accession>
    <name>O86638_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO5718</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939124">
        <property type="protein sequence ID" value="CAA20253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629844.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030410.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5718"/>
    <dbReference type="GeneID" id="1101157"/>
    <dbReference type="KEGG" id="sco:SCO5718"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5809"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036397_1_0_11"/>
    <dbReference type="OMA" id="WIIGFDL"/>
    <dbReference type="PhylomeDB" id="O86638"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAA20253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="524" mass="56256" checksum="AB66C7A54B7A4062" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>O86664</accession>
    <name>O86664_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Very hypotheticl protein SC4A2.08</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO6372</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAA20160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T34983">
        <property type="entry name" value="T34983"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630463.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030869.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO6372"/>
    <dbReference type="GeneID" id="1101813"/>
    <dbReference type="KEGG" id="sco:SCO6372"/>
    <dbReference type="HOGENOM" id="CLU_2636373_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAA20160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="77" mass="8636" checksum="50B3A4FF9B30B884" modified="1998-11-01" version="1">MAADHPETTGHARRVARLIASTTRRDPDLPPLCVSNEFRESSHELGFVAAFILTNTRLLRQRWSRREDGEDTAMSGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O86788</accession>
    <name>TSAE_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tsaE</name>
        <name type="ordered locus">SCO4747</name>
        <name type="ORF">SC6G4.25</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939121">
        <property type="protein sequence ID" value="CAA20403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T35576">
        <property type="entry name" value="T35576"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628905.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029837.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O86788"/>
    <dbReference type="SMR" id="O86788"/>
    <dbReference type="STRING" id="100226.SCO4747"/>
    <dbReference type="GeneID" id="1100188"/>
    <dbReference type="KEGG" id="sco:SCO4747"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4819"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_1_1_11"/>
    <dbReference type="InParanoid" id="O86788"/>
    <dbReference type="OMA" id="SVIVVEW"/>
    <dbReference type="PhylomeDB" id="O86788"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000096218" description="tRNA threonylcarbamoyladenosine biosynthesis protein TsaE">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="148" mass="15755" checksum="5A511C63CADAA724" modified="1998-11-01" version="1">MRELGRRLAKLLRAGDLVMLSGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPSLGDGPPLVHVDAYRLSGGLDEMEDLDLDVSLSDSVIVVEWGEGKVEELTEDRLRLRIDRAVGDTADEVRHVTVTGLGERWATADVSVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O88071</accession>
    <name>O88071_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO1614</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAA20825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36849">
        <property type="entry name" value="T36849"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625890.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027884.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1614"/>
    <dbReference type="GeneID" id="1097045"/>
    <dbReference type="KEGG" id="sco:SCO1614"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1626"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_0_11"/>
    <dbReference type="OMA" id="HSDEQHE"/>
    <dbReference type="PhylomeDB" id="O88071"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAA20825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="236" mass="25442" checksum="6322277A3FE9CEAE" modified="1998-11-01" version="1">MTDRLAPVLRPVRAGNGFEEALEQILQVVRLGLVAAGERLPAERELAERLGISRVTLREVLRVLQDQGLVQARRGRYGGTFVLPRADAGGEDELRRRVAGVDIEDVLRFREVLEAGAAGLCAAHGLAGARAARLRDALAGTRDAPLAQYRRLDTMLHLTLAELCGSPALAAQYAAVRATLNDLLDCIPLLVRNLEHSQRQHAALVEAVLDGDADGAREIAREHCAGTAALLRGFLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-02-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q02059</accession>
    <accession>Q93IZ1</accession>
    <name>ACTI1_STRCO</name>
    <protein>
        <recommendedName>
            <fullName>Actinorhodin polyketide putative beta-ketoacyl synthase 1</fullName>
            <ecNumber>2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>actI ORF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">SCO5087</name>
        <name type="ORF">SCBAC28G1.13</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1992" name="J. Biol. Chem." volume="267" first="19278" last="19290">
            <title>Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.</title>
            <authorList>
                <person name="Fernandez-Moreno M.A."/>
                <person name="Martinez E."/>
                <person name="Boto L."/>
                <person name="Hopwood D.A."/>
                <person name="Malpartida F."/>
            </authorList>
            <dbReference type="PubMed" id="1527048"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-467</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text>Antibiotic biosynthesis; actinorhodin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAA45043" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.-"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC44200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X63449">
        <property type="protein sequence ID" value="CAA45043.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S25840">
        <property type="entry name" value="S25840"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629237.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973891.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="PDB" id="1TQY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/C/E/G=45-467"/>
    </dbReference>
    <dbReference type="PDBsum" id="1TQY"/>
    <dbReference type="AlphaFoldDB" id="Q02059"/>
    <dbReference type="SMR" id="Q02059"/>
    <dbReference type="IntAct" id="Q02059">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5087"/>
    <dbReference type="GeneID" id="1100528"/>
    <dbReference type="KEGG" id="sco:SCO5087"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5167"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_11"/>
    <dbReference type="InParanoid" id="Q02059"/>
    <dbReference type="OMA" id="MNNNFAF"/>
    <dbReference type="PhylomeDB" id="Q02059"/>
    <dbReference type="UniPathway" id="UPA00173"/>
    <dbReference type="EvolutionaryTrace" id="Q02059"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
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    <keyword id="KW-0002">3D-structure</keyword>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PDB" id="1TQY"/>
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</entry>
<entry dataset="Swiss-Prot" created="2020-06-17" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKF0</accession>
    <name>SCBA_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase</fullName>
            <ecNumber evidence="1">2.3.1.277</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Signaling molecule synthase ScbA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scbA</name>
        <name evidence="7" type="ordered locus">SCO6266</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Microbiology" volume="153" first="1394" last="1404">
            <title>ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones.</title>
            <authorList>
                <person name="Hsiao N.H."/>
                <person name="Soeding J."/>
                <person name="Linke D."/>
                <person name="Lange C."/>
                <person name="Hertweck C."/>
                <person name="Wohlleben W."/>
                <person name="Takano E."/>
            </authorList>
            <dbReference type="PubMed" id="17464053"/>
            <dbReference type="DOI" id="10.1099/mic.0.2006/004432-0"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>MUTAGENESIS OF GLU-78; GLU-240 AND ARG-243</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Microb. Biotechnol." volume="4" first="239" last="251">
            <title>Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="D'Alia D."/>
                <person name="Eggle D."/>
                <person name="Nieselt K."/>
                <person name="Hu W.S."/>
                <person name="Breitling R."/>
                <person name="Takano E."/>
            </authorList>
            <dbReference type="PubMed" id="21342469"/>
            <dbReference type="DOI" id="10.1111/j.1751-7915.2010.00232.x"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved of the biosynthesis of S.coelicolor butanolide 1 (SCB1), a gamma-butyrolactone that triggers antibiotic production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:56860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14764"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:141052"/>
            <dbReference type="ChEBI" id="CHEBI:141053"/>
            <dbReference type="EC" id="2.3.1.277"/>
        </reaction>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Deletion of the gene leads to a strong perturbation in the expression of three pigmented antibiotic clusters. It also affects the secondary metabolite cluster responsible for synthesis of the siderophore desferrioxamine and expression of the genes encoding enzymes for primary metabolism pathways, which supply antibiotic precursors and genes for morphological differentiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AfsA family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.277" evidence="1"/>
    <dbReference type="EMBL" id="AL939127">
        <property type="protein sequence ID" value="CAB60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630366.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972659.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000009.1"/>
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    <dbReference type="AlphaFoldDB" id="Q7AKF0"/>
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    <dbReference type="GeneID" id="1101707"/>
    <dbReference type="KEGG" id="sco:SCO6266"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6381"/>
    <dbReference type="eggNOG" id="ENOG50342P2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061800_0_0_11"/>
    <dbReference type="OMA" id="NDHVPGM"/>
    <dbReference type="PhylomeDB" id="Q7AKF0"/>
    <dbReference type="BioCyc" id="MetaCyc:SCO6266-MON"/>
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        <property type="organism ID" value="5998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
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    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000450068" description="2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Cannot produce active gamma-butyrolactones." evidence="2">
        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Cannot produce active gamma-butyrolactones." evidence="2">
        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Cannot produce active gamma-butyrolactones." evidence="2">
        <original>R</original>
        <variation>K</variation>
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B1VN93"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
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    </evidence>
    <evidence type="ECO:0000269" key="3">
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    </evidence>
    <evidence type="ECO:0000303" key="4">
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    </evidence>
    <evidence type="ECO:0000303" key="5">
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        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CAB60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="314" mass="33747" checksum="0F74C9669B6CF389" modified="2012-05-16" version="1">MPEAVVLINSASDANSIEQTALPVPMALVHRTRVQDAFPVSWIPKGGDRFSVTAVLPHDHPFFAPVHGDRHDPLLIAETLRQAAMLVFHAGYGVPVGYHFLMATLDYTCHLDHLGVSGEVAELEVEVACSQLKFRGGQPVQGQVDWAVRRAGRLAATGTATTRFTSPQVYRRMRGDFATPTASVPGTAPVPAARAGRTRDEDVVLSASSQQDTWRLRVDTSHPTLFQRPNDHVPGMLLLEAARQAACLVTGPAPFVPSIGGTRFVRYAEFDSPCWIQATVRPGPAAGLTTVRVTGHQDGSLVFLTTLSGPAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKL0</accession>
    <name>Q7AKL0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative lysR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO3919</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAB46957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T37172">
        <property type="entry name" value="T37172"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628104.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029308.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO3919"/>
    <dbReference type="GeneID" id="1099355"/>
    <dbReference type="KEGG" id="sco:SCO3919"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.3993"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_5_0_11"/>
    <dbReference type="InParanoid" id="Q7AKL0"/>
    <dbReference type="OMA" id="RTFVTVH"/>
    <dbReference type="PhylomeDB" id="Q7AKL0"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB46957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="301" mass="32151" checksum="7A480D01DC1F9090" modified="2012-05-16" version="1">MDLALLRTFVTVHRAGSFTRAAALLGLSQPAVTSQIRTLERQLGRPLFLRQARGVTPTTIGDELAHKAAPHLDALVEIAETGLEDDSTLRTLHLAGPPEFTAERALPALGELTGEDGQAFALRASFGNAEETLEGLAAGHHDLAIGTTRPRGALHTATPLCDEVHVLVATPHWAERAGVEDVRDTDASALKHVPVVEVHESLPFVGRYWASVFDARPASPATVVAPDLRAVLACAVAGAGLAVLPRYLCAEALERGDVVALHDPPVPPLRTYFLVVRTGTLAMPHIARAHEWLLRAAADWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-05-16" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q7AKP1</accession>
    <name>Q7AKP1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative maltose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">SCO2231</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939111">
        <property type="protein sequence ID" value="CAB90879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626482.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003976583.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q7AKP1"/>
    <dbReference type="STRING" id="100226.SCO2231"/>
    <dbReference type="TCDB" id="3.A.1.1.44">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="1097664"/>
    <dbReference type="KEGG" id="sco:SCO2231"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2268"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_11"/>
    <dbReference type="InParanoid" id="Q7AKP1"/>
    <dbReference type="OMA" id="NEAPTYQ"/>
    <dbReference type="PhylomeDB" id="Q7AKP1"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901982">
        <property type="term" value="F:maltose binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015768">
        <property type="term" value="P:maltose transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176022" evidence="4">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAB90879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="423" mass="44624" checksum="EF59E7C72F21DF66" modified="2012-05-16" version="1">MRRGIAATALVASLALAATACGGDGDSDSESGGPVTITYWDTSNATNEAPTYKALVKEFEAANKGVKVNFVNVPFDQAQNKFDTAAGSKGAPDVLRSEVGWTPAFAKKGFFLPLDGTEALAEQDKFQPNLIEQAKYEGKTYGVPLVTDTLAFVYNKELFEKAGVEAPKTWDDLKKAAATVKDKTGVDGYWASTAGYYAQPFLYGEGTDTVDADAKKVTVNAAAAKKGYGTWLSLFDGKGLHKADTTADAYAHIQEAFVSGKVASIIQGPWEITNFYKGTAFKDKNNLGIATVPAGSTGKAGAPTGGHNLSVYAGSDKAHQEAALKFVNFMTSAKSQETVALKNSTLPTRDDAYTAKVKADPGIAGFQTVLPAAQPRPALPEYSSLWTPLDDELPQIAGGKKSLDEGLGDAETAIAKLVPDFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK12</accession>
    <name>Q8CK12_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1941</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAD55184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="T36013">
        <property type="entry name" value="T36013"/>
    </dbReference>
    <dbReference type="PIR" id="T36014">
        <property type="entry name" value="T36014"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733552.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028055.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1941"/>
    <dbReference type="GeneID" id="1097375"/>
    <dbReference type="KEGG" id="sco:SCO1941"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1968"/>
    <dbReference type="eggNOG" id="ENOG5032YXE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068458_0_0_11"/>
    <dbReference type="OMA" id="GNFFGTA"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="322" mass="33981" checksum="9BFAFFFE7D3CC3B1" modified="2003-03-01" version="1">MARTRGSWTGRGLTARSLLNPKQVATAVFHPTWIPPSLDPSIERLKRIRVIGGAVASIGVYTLFEGGFDATQLMENALIASVVLLFITPLVVGAMLFVWRRTGTVRQLRVPLLNALKLLLLFVGCVATLVVLVTTINATGNALVIIVGGLTMLWMLGFVVWGAVRVSGNFFGTAAVHRCLPALLATVTSWLMALPDLVTGDLHGLSLTLGIVFILGAPVTVTVIALAEMGRLKRRYGVRLKAHPATLPPVPGHRPPTPGHLPPTGLPHVPPQGNPFGSPYPPAAGGNPYAPGPHHPHTPPPPPYAPHPSGHPNPYAPGRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q8CK48</accession>
    <name>Q8CK48_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO0691</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939106">
        <property type="protein sequence ID" value="CAD55272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_733511.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027299.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO0691"/>
    <dbReference type="GeneID" id="1096114"/>
    <dbReference type="KEGG" id="sco:SCO0691"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.677"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_2_11"/>
    <dbReference type="InParanoid" id="Q8CK48"/>
    <dbReference type="OMA" id="SWMRAPG"/>
    <dbReference type="PhylomeDB" id="Q8CK48"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
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    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
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    </dbReference>
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        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAD55272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="709" mass="74337" checksum="AE77F439947B8AEE" modified="2003-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q93J71</accession>
    <name>Q93J71_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO2826</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAC44289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_627055.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003975974.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2826"/>
    <dbReference type="GeneID" id="1098260"/>
    <dbReference type="KEGG" id="sco:SCO2826"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2884"/>
    <dbReference type="eggNOG" id="ENOG5033AKZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601783_0_0_11"/>
    <dbReference type="OMA" id="WGHESHR"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC44289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="157" mass="17210" checksum="09A838DB532B1AEC" modified="2001-12-01" version="1">MAATVIALGSLWVSWAQTRAARLHNRQSVRPLLRIRRIRQDDMVGLKLVNAGLGPAVVTRSVVRLDGAAAGEWNREVKGALFTPELWPKTYSLRAGSVVLAGQETFLVLLDRSRSTGSDRLQEFWGLIDRRLVIEVEYESLYGGEGFSVSSATPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JB9</accession>
    <name>Q93JB9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO7477</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939131">
        <property type="protein sequence ID" value="CAC44655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631524.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031687.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7477"/>
    <dbReference type="GeneID" id="1102915"/>
    <dbReference type="KEGG" id="sco:SCO7477"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7589"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619514_0_0_11"/>
    <dbReference type="InParanoid" id="Q93JB9"/>
    <dbReference type="OMA" id="HGQSWGG"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045556">
        <property type="entry name" value="DUF6351"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19878">
        <property type="entry name" value="DUF6351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176578" evidence="2">
        <location>
            <begin position="41"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6351" evidence="3">
        <location>
            <begin position="86"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="497" mass="53763" checksum="95457A7EA9688296" modified="2001-12-01" version="1">MTTPPAPAHDTRPTHRRSRPAVVAAALAAVFLGTLGNVSAAPARAAGEPPAGQSAAGQPSVADCPPALAGKATCYTGRDAGGAYYTMAVPHRWNGSLVVHAHGGPDLGDASDPARSTEDLERWAVMVDQGYAWAASSYRRGGYGARMAAADTENVRRLFTDRFGRPEHTYLHGQSWGGNVAAKAAEIYGRRPGAYDGVLLTNGVLGGGSRGYDYRVDLRVVYQYYCHNHPRPSEPQYPLWQGLRPGSTMTTAGLRARLQECTGYASEPADRTRAQQRNLDDILAVTGIPERTLESHLRFATFTFRDIVTNRLGGRNPWSNRGVRYSGSHDDKALNAGVERFSADPTARRDLSYDSDLTGRVSLPVLTLHAIDDPTAFVEHEAAYRATLRGAGRDQDLVQTFTREHEHSSLSDSEYAASISALDSWVRTGRRPNPRAIAASCAAFDARYAEGCFYDPGFHPAPYAARVRPRPGGLSWPAMTAAQERAWSRIEGVGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF0</accession>
    <name>Q93JF0_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO5977</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630093.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973044.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5977"/>
    <dbReference type="GeneID" id="1101419"/>
    <dbReference type="KEGG" id="sco:SCO5977"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6076"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_11"/>
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    <dbReference type="OMA" id="TRILMSM"/>
    <dbReference type="PhylomeDB" id="Q93JF0"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAC44591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="479" mass="49128" checksum="7692FCEFC5E2757B" modified="2001-12-01" version="1">MPASRVKSPHLLVAESGADREGHGLKRTMGLFQLVCFGVGAIVGTGIFVGLSDSVAEAGPAVVVSFVLAAITCVFTAFAFAELGGAIPVSGSSYSFAYAGLGERTAFLVGWCLLLEYGVSVSAVAVGWSQYVNELLDTVLGVQLPHALSAGPGDGGAVNLPAVVVIALASVLLMRGVRESARATAAMAVLKLAVLLAFCAIGFYAFQDGNLTPFSPAGLGGIGAGTTAAFFSYIGFDAITTAGEEAKNPRRDIPVAILVCIGLVTLLYCAVAVAAIGAVGGDQVGNRPAALSYVVDRVTGSAIGGGVVAFGAVVAIASVVLAVMYGQTRILMSMSRDGLIPRVFEKVSPRTATPVAGTLIVGVVFALPAAFAPLDAVVNLCTIGTLATMAAVNVSVITLRRREPGLARTFRVPLYPATPLLGVGFCLYLMYETGGATWLQFAVFLAVGLLVYSAYGRRHSRLARTAVSADDAERVPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JF4</accession>
    <name>Q93JF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO5973</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939125">
        <property type="protein sequence ID" value="CAC44587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_630089.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030575.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5973"/>
    <dbReference type="GeneID" id="1101415"/>
    <dbReference type="KEGG" id="sco:SCO5973"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.6071"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016728_0_0_11"/>
    <dbReference type="OMA" id="VCEEKHM"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF16542">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="185"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="459"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="784"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC44587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="842" mass="92743" checksum="70D4DE88E95B0422" modified="2001-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q93JL2</accession>
    <name>Q93JL2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4982</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC40595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629134.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003973995.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4982"/>
    <dbReference type="GeneID" id="1100423"/>
    <dbReference type="KEGG" id="sco:SCO4982"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5063"/>
    <dbReference type="HOGENOM" id="CLU_195371_0_0_11"/>
    <dbReference type="OMA" id="PEDPYLE"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC40595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="60" mass="6786" checksum="66868C51E84CF026" modified="2001-12-01" version="1">MADGGDFYSRDRPREPDPQLREDRPRGGGPEDPHQRGNWPVWAIVLAIILVFVVLTVIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q93RW8</accession>
    <name>Q93RW8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">SCO1858</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939110">
        <property type="protein sequence ID" value="CAC38793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626125.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028014.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1858"/>
    <dbReference type="GeneID" id="1097292"/>
    <dbReference type="KEGG" id="sco:SCO1858"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1882"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056929_0_0_11"/>
    <dbReference type="InParanoid" id="Q93RW8"/>
    <dbReference type="OMA" id="SAGHAKG"/>
    <dbReference type="PhylomeDB" id="Q93RW8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC38793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="305" mass="33255" checksum="683EED40486ADB0D" modified="2001-12-01" version="1">MTTPPALLIAGHGTRDEAGAEAFRDFVRELGRRHPELPVAGGFIELSPPPLGDAVAELVERGVRRFAAVPLMLVSAGHAKGDIPAALAREKERHPGITYTYGRPLGPHPGLLRVLERRLAEAVDPAWDPAEVTVLLVGRGSTDPDANAEVFKAARLLWEGRGYAGVETAFVSLAEPDVPGGLERCVRLGARRVVVLPYFLFTGILPDRVRHQTEEWAAAHPETDVRSADVIGPEPELLDLVWERYEEAVGGDLRMNCDSCVYRIALPGFEDKVGLPQQPHFHPDDDGDHPHGHHHGHGHAHSHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q99QK6</accession>
    <name>Q99QK6_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.17</name>
        <name evidence="4" type="ordered locus">SCP1.337c</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="2796" last="2799">
            <title>Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1.</title>
            <authorList>
                <person name="Redenbach M."/>
                <person name="Ikeda K."/>
                <person name="Yamasaki M."/>
                <person name="Kinashi H."/>
            </authorList>
            <dbReference type="PubMed" id="9573173"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2001-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Parkhill J."/>
                <person name="Barrell B.G."/>
                <person name="Rajandream M.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC BAA-471 / A3(2) / M145</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2002-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Brown S.P."/>
                <person name="Murphy L.D."/>
                <person name="Harris D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2009" name="Mol. Microbiol." volume="71" first="763" last="778">
            <title>Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production in Streptomyces coelicolor.</title>
            <authorList>
                <person name="O'Rourke S."/>
                <person name="Wietzorrek A."/>
                <person name="Fowler K."/>
                <person name="Corre C."/>
                <person name="Challis G.L."/>
                <person name="Chater K.F."/>
            </authorList>
            <dbReference type="PubMed" id="19054329"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06560.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">A3</strain>
            <plasmid evidence="5">SCP1</plasmid>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639593.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639945.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039319.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095096"/>
    <dbReference type="GeneID" id="1095419"/>
    <dbReference type="KEGG" id="sco:SCP1.17"/>
    <dbReference type="KEGG" id="sco:SCP1.337c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7962"/>
    <dbReference type="HOGENOM" id="CLU_059876_0_0_11"/>
    <dbReference type="OMA" id="LTVTLWC"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="179"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAC36862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="272" mass="29986" checksum="2D7D6D25B936E9E0" modified="2001-06-01" version="1">MRTSGRGGEGQKYALTSDEDDSDFWGFAQEVEGLFTPLPDEDGARRVHLAGCLPQGGLLRCVDHVGTRRAVAGNAWFELLDGDGATMGSYFVNEVTVIDVKPSASGAGLVDLTVTLWCENALPGAERPWELVRTGRLNHTGMWHELAPEDRHAWLSVALWSREYQRQAKPDAPAGQVFTLDGRHIVDRDTFYCAIGEAINGPGGYFGWNLDALDDCLRGGWGATTPFTLHWDFSAEARTRLAEHVPAGDRELVLFDLLLEIFEERGVSVILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9ACP5</accession>
    <name>Q9ACP5_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCP1.273c</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639883.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039575.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095356"/>
    <dbReference type="KEGG" id="sco:SCP1.273c"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.8216"/>
    <dbReference type="HOGENOM" id="CLU_003050_1_0_11"/>
    <dbReference type="OMA" id="DGVPDIW"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004323936" evidence="2">
        <location>
            <begin position="38"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="1039" mass="110124" checksum="ABCA1F4013696B7A" modified="2001-06-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD17</accession>
    <name>Q9AD17_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCP1.133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>SCP1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL589148">
        <property type="protein sequence ID" value="CAC36654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_639706.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011039432.1">
        <property type="nucleotide sequence ID" value="NC_003903.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1095211"/>
    <dbReference type="KEGG" id="sco:SCP1.133"/>
    <dbReference type="HOGENOM" id="CLU_2541016_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Plasmid SCP1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC36654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="83" mass="8803" checksum="EDDE5742238DD6B6" modified="2001-06-01" version="1">MASANGLLAVHEHGPNRVASPCDRCGARQDEHGHHLGCPEPHPGVPGSGPAQAPPLEMHRLILHNTVMPSEARQKGGPVREDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AD91</accession>
    <name>Q9AD91_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO1676</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939109">
        <property type="protein sequence ID" value="CAC36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625951.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977149.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1676"/>
    <dbReference type="GeneID" id="1097107"/>
    <dbReference type="KEGG" id="sco:SCO1676"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1693"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_2_11"/>
    <dbReference type="InParanoid" id="Q9AD91"/>
    <dbReference type="OMA" id="NYGDHSG"/>
    <dbReference type="PhylomeDB" id="Q9AD91"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008777">
        <property type="term" value="F:acetylornithine deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="205"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="445" mass="47880" checksum="95C6E4F7F2D56CE6" modified="2001-06-01" version="1">MSDSGTATGTARTVTGEDEVVDLCRELIRIDTSNYGDHSGPGERKAAEYVAEKLAEVGLEPKIFESHPGRASTVARIEGEDPSRPALLIHGHTDVVPANADDWTHHPFSGEVADGCVWGRGAVDMKDMDAMTLAVVRDRLRSGRKPPRDIVLAFLADEEAGGTYGARHLVDHHPDLFEGVTEAISEVGGFSFTVNEQRRLYLIQTAEKGIHWMKLTVAGTAGHGSMIHRDNAITELSEAVARLGRHTFPVRVTKTTRAFLDELGDALGTDLDPENMEGTLAKLGGIAKLIGATLSNTANPTQLGAGYKVNVIPGEATAHIDGRYLPGYEEEFLADVDRILGPHVRREDVHANKAVETTFDGALVDAMQSALVAEDPAAKAVPYMLSGGTDAKSFDELGIRGFGFAPLKLPPELDFAGMFHGVDERVPVEGLQFGVRVLDRFIDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9AK54</accession>
    <name>Q9AK54_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4063</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939118">
        <property type="protein sequence ID" value="CAC32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628245.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029412.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4063"/>
    <dbReference type="GeneID" id="1099499"/>
    <dbReference type="KEGG" id="sco:SCO4063"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4124"/>
    <dbReference type="HOGENOM" id="CLU_2071741_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030176628" evidence="1">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="118" mass="13034" checksum="B0F4172225AD4592" modified="2001-06-01" version="1">MRRAVHRSLLALFAALGITLASSTAANAHYVYYADLVWSNADSSRCVMNRSETSHGSTGGGYFRGDSMSQAELSSIPSDCILPWERNTGWLAEGFVIYKWYVDAQGDGSWLICDRTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWK3</accession>
    <name>Q9EWK3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7790</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC19747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631820.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031913.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7790"/>
    <dbReference type="GeneID" id="1103227"/>
    <dbReference type="KEGG" id="sco:SCO7790"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7906"/>
    <dbReference type="HOGENOM" id="CLU_2620412_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015791">
        <property type="entry name" value="Antimic/Inh_G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015161">
        <property type="entry name" value="Sklp_toxin_b/g_crystallin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09076">
        <property type="entry name" value="Crystall_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Crystall_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC19747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="78" mass="8866" checksum="265ACB127FDB3629" modified="2001-03-01" version="1">MCASRTPTAHSQSYCFANKGTYRFTESGPGTTVWVDKISTGNNWVNYHDANGTTVAYRKHYIISFPTRPPHVDWIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9EWV3</accession>
    <name>Q9EWV3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO4943</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC21631.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629095.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029966.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000027.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1100384"/>
    <dbReference type="KEGG" id="sco:SCO4943"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5023"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_11"/>
    <dbReference type="InParanoid" id="Q9EWV3"/>
    <dbReference type="OMA" id="MTMAYGA"/>
    <dbReference type="PhylomeDB" id="Q9EWV3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004033">
        <property type="term" value="F:aldo-keto reductase (NADP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC21631.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="330" mass="36195" checksum="74DDFD027DB8D9A8" modified="2002-10-01" version="2">MQHRTLGQQGLRVSALGLGVMGMSLAYGPSNDEDGISTIHRAHELGVDFFDTAELYGQGTGSNETLLGNAVNDFRDEVVLATKFGFDMTSKSLGSGVNSRPENIREVAENSLRYLRTDRIDLFYQHISDPDVPAEEVAGTVGDLITEGKVRYFGLSNVGPRYIRRAHAVTPVTALQYEYSIFEREVEDEILPVVRELGIGLVPYSPLGRGFLSGVVRPAGEYPEDDMRRWDERWQGENYAYNLNAAEQLRKLAATKGITPAQLALAWLLAQGEDVVPIPGTRSAARLEENVGAIDAELTEADLARIREVIPQGSAGSRYPASMMAGFRTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F2V8</accession>
    <name>NUOI2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I 2</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit I 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit I 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoI2</name>
        <name type="ordered locus">SCO4603</name>
        <name type="ORF">SCD39.03</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939120">
        <property type="protein sequence ID" value="CAC08256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628765.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003974344.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9F2V8"/>
    <dbReference type="SMR" id="Q9F2V8"/>
    <dbReference type="STRING" id="100226.SCO4603"/>
    <dbReference type="GeneID" id="1100043"/>
    <dbReference type="KEGG" id="sco:SCO4603"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4675"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_2_11"/>
    <dbReference type="InParanoid" id="Q9F2V8"/>
    <dbReference type="OMA" id="PVVDWVM"/>
    <dbReference type="PhylomeDB" id="Q9F2V8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000250946" description="NADH-quinone oxidoreductase subunit I 2">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="197" mass="21845" checksum="75A4ABE40F646DBA" modified="2001-03-01" version="1">MAPVPGSGLAKGLAVTLRTMTRKTVTEQYPDAQPELPPRTRGVIGLFEENCTVCMLCARECPDWCIYIDSHKETVPAATPGGRDRSRNVLDRFAIDFALCMYCGICIEVCPFDALFWSPEFEYAETDIRDLTHERDKLREWMWTVPAPPALDPGAEEPKELAAARKAADKLAAQQQPDQPGPDHPGQPDESGQEGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-04-07" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3A1</accession>
    <name>Q9F3A1_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO7574</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631617.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031758.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1103012"/>
    <dbReference type="KEGG" id="sco:SCO7574"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7689"/>
    <dbReference type="eggNOG" id="ENOG503266W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3158359_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC16454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="49" mass="5023" checksum="D0E949EF8EBD7956" modified="2001-03-01" version="1">MILLALLLPVVMMAFLFAADALEDLIFPPPAAPAEDGPAADIAEATTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3B8</accession>
    <name>Q9F3B8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sugar transport integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">SCO7557</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631600.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971587.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7557"/>
    <dbReference type="GeneID" id="1102995"/>
    <dbReference type="KEGG" id="sco:SCO7557"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7671"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_11"/>
    <dbReference type="InParanoid" id="Q9F3B8"/>
    <dbReference type="OMA" id="MITFVHA"/>
    <dbReference type="PhylomeDB" id="Q9F3B8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAC16437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="307" mass="33100" checksum="75D2A1323146D0F5" modified="2001-03-01" version="1">MTTQSLPARTDAPARTSAAKPAGRGGRRLLRQRAGRQHHAGPLAYVLLAVMAILSIFPLYWTMVAASTDNTRVSQTPPPFLPGPNLFSNLARAWDEAAMGKAMVNSLIVAGVIALSTVLFATLAGFAFAKLRFKGRNALLMLVIGTMMVPPQLAVVPLFMMMADLGWSQQLPAVIFPTLVSAVGVFFMRQYLTEALPDELVEAGRVDGAHSLRIFFSIVLPIARPAMAVLFMITFVHAWNDFFWPFVVLDMTNPTVPVALTQLSAGYVRDQSLIMAGALLGTLPLLAMFVVFGRQIVSGIMAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3D2</accession>
    <name>Q9F3D2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO7625</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631666.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031785.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7625"/>
    <dbReference type="DNASU" id="1103063"/>
    <dbReference type="GeneID" id="1103063"/>
    <dbReference type="KEGG" id="sco:SCO7625"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7744"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_4_0_11"/>
    <dbReference type="InParanoid" id="Q9F3D2"/>
    <dbReference type="OMA" id="EGQAMRI"/>
    <dbReference type="PhylomeDB" id="Q9F3D2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAC16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="373" mass="40024" checksum="13B5D7BBFDC0E61B" modified="2001-03-01" version="1">MRQRIAVVGGGPAGLAFARVMHRHDRSVTVLERDPAPDARPPGGTLDLHEGLGRLAMDKAGLSAEFEALSRPEGQAMRILDTDGTVLRDWRPDPAERANPEIDRGQLRDLLLGPLDVRWGQGVTKVVPGGRDGVLVHFEDGRQEAFDLVVGADGAWSRTRPAVSPVTPHYTGVTSVETSLDDVDTRHPDLARLVGDGSVAVYGVNRAVVAQRNSGGHVKVHAQFRAPLDWHAHLDLGDAEAVRSRLLTLFDGWTAPVLDLLRHGTGFVHRPLHVLPVSHTWTHVPGVTLLGDAAHLMPPLGAGANLALLEGAELAESLADGSADPDDAVRAFEERMWARAGRWAKITAAGLERLVSPDPAAALAVFDQVQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9F3Q2</accession>
    <name>Q9F3Q2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular small neutral protease</fullName>
            <ecNumber evidence="5">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">SCO7635</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M7 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="5"/>
    <dbReference type="EMBL" id="AL939132">
        <property type="protein sequence ID" value="CAC16968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631675.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003971509.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7635"/>
    <dbReference type="GeneID" id="1103073"/>
    <dbReference type="KEGG" id="sco:SCO7635"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7754"/>
    <dbReference type="eggNOG" id="COG5640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124996_0_0_11"/>
    <dbReference type="OMA" id="AAIWNDS"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025392314" description="Extracellular small neutral protease" evidence="8">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAC16968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="182" mass="18770" checksum="F1E1E339A4F83CC1" modified="2001-03-01" version="1">MHVRTLTGCLAAALLSLPLLSGQAVAAESPAAARVLTYDASGSAEFRSAVDRGAAIWNESVENAELRPVSAGQRADIRILADDGWPRALPTSLGKGTVWIGRQAVDEGYNTVRISSHELGHILGLPDRKPGPCSSLMSGSSAGVPCTNPYPNAAEKAEVEDNFAGAAGSRAVAGPVPVLIED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBM3</accession>
    <name>EX7L_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="1">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseA</name>
        <name type="ordered locus">SCO5056</name>
        <name type="ORF">SCK7.29c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629208.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030027.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FBM3"/>
    <dbReference type="STRING" id="100226.SCO5056"/>
    <dbReference type="GeneID" id="1100497"/>
    <dbReference type="KEGG" id="sco:SCO5056"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_2_1_11"/>
    <dbReference type="InParanoid" id="Q9FBM3"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="PhylomeDB" id="Q9FBM3"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000197889" description="Exodeoxyribonuclease 7 large subunit">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <sequence length="402" mass="43882" checksum="145929A8372B4E08" modified="2001-03-01" version="1">MAANSTPEGPLPVGEVSRLIGGWIDRLGAVWVEGQITQLSRRPGAGVVFLTLRDPSYDISVSVTCYRQVFDAVADVVGEGARVVVHAKPEWYAPRGQLSLRAAEIKPVGVGELLARLEQLKKALAREGLFAAERKQPLPFLPQLIGLVCGRASAAERDVLENARHRWPAVRFEVRNVPVQGVHAVPQVVQAVKELDARDDVDVIVVARGGGSVEDLLPFSDEQLVRAVAACRTPVVSAIGHEPDSPLLDLVADLRASTPTDAAKKVVPDVGEEYERVRLLRDRARRCVAAFVDREERGLAHALARPSIQDPHRMIEERAEQVTALLDRGRRSLRHHLDRADSELTHTHARVVALSPAATLKRGYAVLQRADGHAVRDPGEVEPGETLRARVSEGDFSVRVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBN9</accession>
    <name>Q9FBN9_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">SCO5039</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AL939122">
        <property type="protein sequence ID" value="CAC05884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_629191.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011030015.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO5039"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="GeneID" id="1100480"/>
    <dbReference type="KEGG" id="sco:SCO5039"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.5117"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_6_0_11"/>
    <dbReference type="InParanoid" id="Q9FBN9"/>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="PhylomeDB" id="Q9FBN9"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="320"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAC05884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="716" mass="76860" checksum="0B91C806C290E221" modified="2001-03-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FBU3</accession>
    <name>Q9FBU3_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7148</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC01637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631207.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011031461.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7148"/>
    <dbReference type="GeneID" id="1102586"/>
    <dbReference type="KEGG" id="sco:SCO7148"/>
    <dbReference type="HOGENOM" id="CLU_168322_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC01637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="117" mass="12298" checksum="E5D4E2251FC37FB9" modified="2001-03-01" version="1">MSMVLVSANRTQSYGLGLRGRVLSCGVKVYGHTGTVQGYWMVNASNNGTVNTVLAGTPERHRHTGKTPARRTGASLRRGRSPVSRTAPRSGHMSQAHAGVTTAPAWTPTGRTSGADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FC61</accession>
    <name>Q9FC61_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO7125</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939130">
        <property type="protein sequence ID" value="CAC04231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_631186.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003972018.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO7125"/>
    <dbReference type="GeneID" id="1102563"/>
    <dbReference type="KEGG" id="sco:SCO7125"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.7225"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_5_2_11"/>
    <dbReference type="InParanoid" id="Q9FC61"/>
    <dbReference type="PhylomeDB" id="Q9FC61"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAC04231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="246" mass="25752" checksum="3736FD74F665AD2F" modified="2001-03-01" version="1">MRVVVAGATGLIGSRTVARLRDHGVEVVPVSRGEGVDVSTGQGLDRALRGAEVVVDVTDAPSRRQETSTAFFTTATGNVLKAAAAADVEHYVALSVVGADRIGSGYFRAKAAQEDLARHTTVPYSVVRATPFHESVEAAAAAGTRPDGVHVPPLSLRPVSADDVAAAVAHVAVGLPQFGVVETAGPEELRLEDLTAEVLNFLGRPGPVITDSLAPFFGAVLEERDLLPGPDARLGHHTFTQWLKSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCD2</accession>
    <name>URE2_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease subunit beta</fullName>
            <ecNumber evidence="1">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureB</name>
        <name type="ordered locus">SCO1235</name>
        <name type="ORF">2SCG1.10c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAC01459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625523.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003977596.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9FCD2"/>
    <dbReference type="SMR" id="Q9FCD2"/>
    <dbReference type="STRING" id="100226.SCO1235"/>
    <dbReference type="PRIDE" id="Q9FCD2"/>
    <dbReference type="GeneID" id="1096658"/>
    <dbReference type="KEGG" id="sco:SCO1235"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1234"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_1_0_11"/>
    <dbReference type="InParanoid" id="Q9FCD2"/>
    <dbReference type="OMA" id="FYEVNDA"/>
    <dbReference type="PhylomeDB" id="Q9FCD2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
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        <property type="term" value="P:urea catabolic process"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="urease_beta"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000234278" description="Urease subunit beta">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <sequence length="103" mass="10825" checksum="F8A288673EF663F4" modified="2001-03-01" version="1">MIPGEILFADEPVAFNEGREAVRLTVLNTADRPVQVGSHYHFAEANPGLEFDRAAAHGRRLDIAAGTAVRFEPGIPVDVRLIPLAGARVVVGLRGATGGALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FCF4</accession>
    <name>Q9FCF4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO4216</name>
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    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAC04052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_003888.3"/>
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        <property type="nucleotide sequence ID" value="NZ_VNID01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4216"/>
    <dbReference type="GeneID" id="1099656"/>
    <dbReference type="KEGG" id="sco:SCO4216"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4279"/>
    <dbReference type="eggNOG" id="ENOG5031U01">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2774188_0_0_11"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAC04052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="69" mass="7746" checksum="63990D3382AC5AC1" modified="2001-03-01" version="1">MTDGTAVDVADEQIVSNQIIRGIKTLRDHLDCSVHEALDVFVARYAVLRAERPGDFACGHDEYWTGFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="153" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3L4</accession>
    <name>Q9K3L4_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative metal transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">SCO1046</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB96031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625341.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027542.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1046"/>
    <dbReference type="GeneID" id="1096469"/>
    <dbReference type="KEGG" id="sco:SCO1046"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1041"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_11"/>
    <dbReference type="InParanoid" id="Q9K3L4"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="PhylomeDB" id="Q9K3L4"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAB96031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="753" mass="77133" checksum="635E6884EF4565EF" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3U9</accession>
    <name>Q9K3U9_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">SCO4396</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB95907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628565.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029630.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO4396"/>
    <dbReference type="GeneID" id="1099836"/>
    <dbReference type="KEGG" id="sco:SCO4396"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4464"/>
    <dbReference type="eggNOG" id="ENOG502Z89R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025319_1_0_11"/>
    <dbReference type="OMA" id="GWAVMPL"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAB95907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="550" mass="56813" checksum="4B727299B1ACAC32" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K3Y8</accession>
    <name>Q9K3Y8_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative 3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">SCO1345</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939108">
        <property type="protein sequence ID" value="CAB95802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_625630.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011027733.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO1345"/>
    <dbReference type="GeneID" id="1096768"/>
    <dbReference type="KEGG" id="sco:SCO1345"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.1352"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_11"/>
    <dbReference type="InParanoid" id="Q9K3Y8"/>
    <dbReference type="OMA" id="FPQWGAY"/>
    <dbReference type="PhylomeDB" id="Q9K3Y8"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB95802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="253" mass="26271" checksum="362DD2939916B8FE" modified="2000-10-01" version="1">MTELPEPSGKVALVTGASRGIGYGVAEALVARGDRVCITGRNEDALKEAVDRLGPDRVIGVAGKAHDEAHQAVAVERVMEAFGRVDFLVNNAGTNPVFGPIADLDLNVARKVFETNVISALGFAQRTWHAWQKDNGGAIVNIASVAGLSPSPFIAAYGVSKAALINLTAQLAHEFAPRVRVNAIAPAVVKTKFAAALYEGREEEAAAGYPLGRLGVPSDIGGAAEFLTSEQSAWVTGQTLVVDGGIFLNAGVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9K4F6</accession>
    <name>DTD_STRCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">SCO4182</name>
        <name type="ORF">SCD66.19c</name>
    </gene>
    <organism>
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="AL939119">
        <property type="protein sequence ID" value="CAB94086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_628358.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011029487.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9K4F6"/>
    <dbReference type="SMR" id="Q9K4F6"/>
    <dbReference type="STRING" id="100226.SCO4182"/>
    <dbReference type="GeneID" id="1099622"/>
    <dbReference type="KEGG" id="sco:SCO4182"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.4246"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_2_11"/>
    <dbReference type="InParanoid" id="Q9K4F6"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="PhylomeDB" id="Q9K4F6"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006399">
        <property type="term" value="P:tRNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000164597" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="141" mass="14968" checksum="55F42ECAAF299E37" modified="2000-10-01" version="1">MRAVVQRVDGASVVVDGETVGAIDGEGLCVLVGVTHDDTKEKAAQLARKLWSVRILHDEKSCSDLDAPLLVISQFTLYGDARKGRRPTWNAAAPGDVAEPLVDEVVAQLRALGATVATGRFGAQMRVSLTNDGPFTVLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KXK2</accession>
    <name>Q9KXK2_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">SCO2318</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB93438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626565.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028276.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2318"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GeneID" id="1097752"/>
    <dbReference type="KEGG" id="sco:SCO2318"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2355"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_4_11"/>
    <dbReference type="InParanoid" id="Q9KXK2"/>
    <dbReference type="OMA" id="FCGGQGV"/>
    <dbReference type="PhylomeDB" id="Q9KXK2"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="36"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="255"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAB93438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="498" mass="52949" checksum="E876836B07BAFD4F" modified="2000-10-01" version="1">MTAEASQTGPRPEPAADGLPPLRIALLTYKGNPFCGGQGVYVRHLSRELARLGHRVEVIGAQPYPVLDDGPLVGDRLSLTELPSLDLYRQPDPFRTPKRGEYRDWIDALEVGTMWTGGFPEPLTFSLRARRHLRARRGDFDVVHDNQTLGYGLLGDVGAPLVTTIHHPITVDRQLELDAADSRGRRYSVRRWYAFTRMQKRVARRLPSVLTVSGTSRQEIVDHLGVRDDRIHVVHIGADTDLFSPDPSVPRVPGRIVTTSSADVPLKGLVFLVEALAKARTEHPRAHLVVVGKRPAEGPVAQAIERYGLAGAVEFVKGISDAELVDLVRSAEVACVPSLYEGFSLPAAEAMATGTALLATTGGAVPEVAGPDGETCLAVPPGDADALAAGLNRLLGDRSLRARLGAAGRERVLRHFTWARAAEGTVARYREAIGRRPSGTSTPSAPSAASTPSAASTPSAASASGAVSAGQKPAPAPTPTPTSTTSDTGVYPESRATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9KY24</accession>
    <name>Q9KY24_STRCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">SCO2366</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)</name>
        <dbReference type="NCBI Taxonomy" id="100226"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Streptomyces</taxon>
            <taxon>Streptomyces albidoflavus group</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2002" name="Nature" volume="417" first="141" last="147">
            <title>Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).</title>
            <authorList>
                <person name="Bentley S.D."/>
                <person name="Chater K.F."/>
                <person name="Cerdeno-Tarraga A.M."/>
                <person name="Challis G.L."/>
                <person name="Thomson N.R."/>
                <person name="James K.D."/>
                <person name="Harris D.E."/>
                <person name="Quail M.A."/>
                <person name="Kieser H."/>
                <person name="Harper D."/>
                <person name="Bateman A."/>
                <person name="Brown S."/>
                <person name="Chandra G."/>
                <person name="Chen C.W."/>
                <person name="Collins M."/>
                <person name="Cronin A."/>
                <person name="Fraser A."/>
                <person name="Goble A."/>
                <person name="Hidalgo J."/>
                <person name="Hornsby T."/>
                <person name="Howarth S."/>
                <person name="Huang C.H."/>
                <person name="Kieser T."/>
                <person name="Larke L."/>
                <person name="Murphy L."/>
                <person name="Oliver K."/>
                <person name="O'Neil S."/>
                <person name="Rabbinowitsch E."/>
                <person name="Rajandream M.A."/>
                <person name="Rutherford K."/>
                <person name="Rutter S."/>
                <person name="Seeger K."/>
                <person name="Saunders D."/>
                <person name="Sharp S."/>
                <person name="Squares R."/>
                <person name="Squares S."/>
                <person name="Taylor K."/>
                <person name="Warren T."/>
                <person name="Wietzorrek A."/>
                <person name="Woodward J."/>
                <person name="Barrell B.G."/>
                <person name="Parkhill J."/>
                <person name="Hopwood D.A."/>
            </authorList>
            <dbReference type="PubMed" id="12000953"/>
            <dbReference type="DOI" id="10.1038/417141a"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC BAA-471 / A3(2) / M145</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AL939112">
        <property type="protein sequence ID" value="CAB92842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_626613.1">
        <property type="nucleotide sequence ID" value="NC_003888.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011028309.1">
        <property type="nucleotide sequence ID" value="NZ_VNID01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="100226.SCO2366"/>
    <dbReference type="GeneID" id="1097800"/>
    <dbReference type="KEGG" id="sco:SCO2366"/>
    <dbReference type="PATRIC" id="fig|100226.15.peg.2405"/>
    <dbReference type="eggNOG" id="COG2899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034539_1_0_11"/>
    <dbReference type="InParanoid" id="Q9KY24"/>
    <dbReference type="OMA" id="EYVYLEH"/>
    <dbReference type="PhylomeDB" id="Q9KY24"/>
    <dbReference type="Proteomes" id="UP000001973">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAB92842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000001973"/>
        </source>
    </evidence>
    <sequence length="380" mass="41067" checksum="57C22CA4675839ED" modified="2000-10-01" version="1">MLLKTFGWSFAVTALGLVAAVFYGGWTAFGIVAILSIMEISLSFDNAVVNAGILKKMNAFWQKIFLTVGILIAVFGMRLVFPVVIVAISASLGPIEAVDLALTDKDRYQELVTDAHPSIAAFGGMFLLMIFLDFIFEDRDIKWLAWLERPLAKLGKVDMLSVCIALVVLLVSAITFGAHAHQHGGAHADKAETVLLAGIAGLITYMIVGGLSGYFEDKLEEEEEREHEEEEEAARTGKPKSAVRLAGKAAFFMFLYLEVLDASFSFDGVIGAFAITNDIVLMALGLGIGAMYVRSLTVYLVR